DE602006018299D1 - Platinanaloga mit monoazolligand - Google Patents
Platinanaloga mit monoazolligandInfo
- Publication number
- DE602006018299D1 DE602006018299D1 DE602006018299T DE602006018299T DE602006018299D1 DE 602006018299 D1 DE602006018299 D1 DE 602006018299D1 DE 602006018299 T DE602006018299 T DE 602006018299T DE 602006018299 T DE602006018299 T DE 602006018299T DE 602006018299 D1 DE602006018299 D1 DE 602006018299D1
- Authority
- DE
- Germany
- Prior art keywords
- rna
- dna
- platinum
- analogs
- replication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052697 platinum Inorganic materials 0.000 abstract 3
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000002452 interceptive effect Effects 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 230000010076 replication Effects 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000003851 azoles Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000006790 cellular biosynthetic process Effects 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- -1 hydroxide ions Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 150000003057 platinum Chemical class 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Medicines Containing Plant Substances (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69563605P | 2005-06-30 | 2005-06-30 | |
| PCT/US2006/002998 WO2007005058A2 (en) | 2005-06-30 | 2006-01-26 | Monoazole ligand platinum analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006018299D1 true DE602006018299D1 (de) | 2010-12-30 |
Family
ID=37604911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006018299T Active DE602006018299D1 (de) | 2005-06-30 | 2006-01-26 | Platinanaloga mit monoazolligand |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7759488B2 (de) |
| EP (1) | EP1896491B1 (de) |
| JP (1) | JP5193032B2 (de) |
| CN (1) | CN101495459A (de) |
| AT (1) | ATE488507T1 (de) |
| AU (1) | AU2006266446B2 (de) |
| CA (1) | CA2612710C (de) |
| DE (1) | DE602006018299D1 (de) |
| MX (1) | MX2007015852A (de) |
| WO (1) | WO2007005058A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010005548A2 (en) * | 2008-07-07 | 2010-01-14 | Northwestern University | Functionalization of carbon nanotubes with metallic moieties |
| CA2802882C (en) | 2010-06-18 | 2018-10-30 | Jerry Lanchbury | Methods and materials for assessing loss of heterozygosity |
| ES2588979T3 (es) | 2010-08-24 | 2016-11-08 | Dana-Farber Cancer Institute, Inc. | Procedimientos para la predicción de una respuesta contra el cáncer |
| EP2721181B1 (de) | 2011-06-17 | 2019-12-18 | Myriad Genetics, Inc. | Verfahren und materialien zur beurteilung eines allel-ungleichgewichts |
| EP2794907B2 (de) | 2011-12-21 | 2022-11-23 | Myriad Genetics, Inc. | Verfahren und materialien zur bewertung des verlusts der heterozygotie |
| CA2864481C (en) | 2012-02-23 | 2020-07-14 | The Children's Hospital Corporation | Methods for predicting anti-cancer response |
| EP2859118B1 (de) | 2012-06-07 | 2017-11-22 | Institut Curie | Verfahren zur detektion der deaktivierung des pfades der homologen rekombination (brca1/2) in menschlichen tumoren |
| US10308986B2 (en) | 2013-03-14 | 2019-06-04 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| ES2777228T3 (es) | 2013-04-05 | 2020-08-04 | Myriad Genetics Inc | Métodos para evaluar la deficiencia de recombinación homóloga y predecir la respuesta al tratamiento del cáncer |
| US11149316B2 (en) | 2013-12-09 | 2021-10-19 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors |
| ES2800673T3 (es) | 2014-08-15 | 2021-01-04 | Myriad Genetics Inc | Métodos y materiales para evaluar una deficiencia de recombinación homóloga |
| WO2016085504A1 (en) * | 2014-11-26 | 2016-06-02 | Hewlett-Packard Indigo B.V. | Rosette-free printing |
| EP4141127A1 (de) | 2021-08-30 | 2023-03-01 | Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln | Verfahren zur bewertung des mangels an homologer rekombination in eierstockkrebszellen |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3424739A (en) * | 1966-01-19 | 1969-01-28 | Massachusetts Inst Technology | Azo-containing organo-metallic complexes |
| US5107007A (en) * | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| US4921963A (en) * | 1987-04-13 | 1990-05-01 | British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
| US5624919A (en) * | 1993-09-14 | 1997-04-29 | The University Of Vermont And State Agricultural College | Trans platinum (IV) complexes |
| US6806289B1 (en) | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
| US6894049B1 (en) * | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
| GB0120618D0 (en) * | 2001-08-24 | 2001-10-17 | Univerity Court Of The Univers | Photoreactive compounds and compositions |
| JP2007502777A (ja) * | 2003-08-13 | 2007-02-15 | ユニバーシティー オブ サウス フロリダ | 腫瘍の処置のための白金錯体 |
-
2006
- 2006-01-26 DE DE602006018299T patent/DE602006018299D1/de active Active
- 2006-01-26 AT AT06719723T patent/ATE488507T1/de active
- 2006-01-26 US US11/340,805 patent/US7759488B2/en not_active Expired - Fee Related
- 2006-01-26 CN CNA2006800237222A patent/CN101495459A/zh active Pending
- 2006-01-26 AU AU2006266446A patent/AU2006266446B2/en not_active Ceased
- 2006-01-26 EP EP06719723A patent/EP1896491B1/de not_active Not-in-force
- 2006-01-26 MX MX2007015852A patent/MX2007015852A/es active IP Right Grant
- 2006-01-26 CA CA2612710A patent/CA2612710C/en not_active Expired - Fee Related
- 2006-01-26 WO PCT/US2006/002998 patent/WO2007005058A2/en active Application Filing
- 2006-01-26 JP JP2008519260A patent/JP5193032B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070004696A1 (en) | 2007-01-04 |
| CA2612710A1 (en) | 2007-01-11 |
| EP1896491A2 (de) | 2008-03-12 |
| AU2006266446A1 (en) | 2007-01-11 |
| JP5193032B2 (ja) | 2013-05-08 |
| MX2007015852A (es) | 2008-02-22 |
| JP2009501154A (ja) | 2009-01-15 |
| WO2007005058A3 (en) | 2009-04-16 |
| EP1896491A4 (de) | 2009-12-09 |
| CN101495459A (zh) | 2009-07-29 |
| EP1896491B1 (de) | 2010-11-17 |
| AU2006266446B2 (en) | 2011-03-10 |
| CA2612710C (en) | 2013-05-14 |
| US7759488B2 (en) | 2010-07-20 |
| WO2007005058A2 (en) | 2007-01-11 |
| ATE488507T1 (de) | 2010-12-15 |
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