MX2015005328A - Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas. - Google Patents

Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas.

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Publication number
MX2015005328A
MX2015005328A MX2015005328A MX2015005328A MX2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A MX 2015005328 A MX2015005328 A MX 2015005328A
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Mexico
Prior art keywords
nucleic acid
compositions
methods
cell types
target nucleic
Prior art date
Application number
MX2015005328A
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English (en)
Inventor
Maria Del Carmen Carmona Orozco
Andrés Pablo Montefeltro
Gabriel G Alvarado
Analia Bortolozzi
Raquel Revilla-Sanchez
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Nlife Therapeutics S L
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Publication date
Application filed by Nlife Therapeutics S L filed Critical Nlife Therapeutics S L
Publication of MX2015005328A publication Critical patent/MX2015005328A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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Abstract

La invención proporciona un conjugado que comprende (i) un ácido nucleico que es complementario a la secuencia de un ácido nucleico diana y cuya expresión previene o reduce la expresión del ácido nucleico diana y (ii) un agente de selectividad que es capaz de unirse con alta afinidad a un receptor que puede ser internalizado por la célula tras la unión a dicho agente de selectividad. Los conjugados de la presente invención son útiles para la administración de ácidos nucleicos a una célula de interés y de esta manera, para el tratamiento de enfermedades que requieren el descenso de la proteína codificada por el ácido nucleico diana así como para la administración de agentes de contraste a las células para fines diagnósticos.
MX2015005328A 2012-10-26 2013-10-25 Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas. MX2015005328A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719297P 2012-10-26 2012-10-26
EP12382413 2012-10-26
PCT/EP2013/072411 WO2014064258A1 (en) 2012-10-26 2013-10-25 Compositions and methods for selective delivery of oligonucleotide molecules to cell types

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MX2015005328A true MX2015005328A (es) 2015-09-25

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MX2015005328A MX2015005328A (es) 2012-10-26 2013-10-25 Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas.

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US (3) US9938525B2 (es)
EP (1) EP2911697A1 (es)
JP (1) JP2016503394A (es)
AU (1) AU2013336582A1 (es)
CA (1) CA2889608A1 (es)
MX (1) MX2015005328A (es)
WO (1) WO2014064258A1 (es)

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