MX342764B - Composiciones y metodos para la distribucion selectiva de moleculas de oligonucleotidos a tipos especificos de neuronas. - Google Patents

Composiciones y metodos para la distribucion selectiva de moleculas de oligonucleotidos a tipos especificos de neuronas.

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Publication number
MX342764B
MX342764B MX2012012214A MX2012012214A MX342764B MX 342764 B MX342764 B MX 342764B MX 2012012214 A MX2012012214 A MX 2012012214A MX 2012012214 A MX2012012214 A MX 2012012214A MX 342764 B MX342764 B MX 342764B
Authority
MX
Mexico
Prior art keywords
nucleic acid
compositions
methods
oligonucleotide molecules
selective delivery
Prior art date
Application number
MX2012012214A
Other languages
English (en)
Other versions
MX2012012214A (es
Inventor
Pablo Montefeltro Andrés
Alvarado Urbina Gabriel
Bortolozzi Biassoni Analia
Vila Bover Miquel
Artigas Pérez Francesc
Original Assignee
Nlife Therapeutics S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10382087A external-priority patent/EP2380595A1/en
Application filed by Nlife Therapeutics S L filed Critical Nlife Therapeutics S L
Publication of MX2012012214A publication Critical patent/MX2012012214A/es
Publication of MX342764B publication Critical patent/MX342764B/es

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

La presente invención se refiere a un conjugado que comprende (i) un ácido nucleico que es complementario a la secuencia de ácido nucleico diana y cuya expresión previene o reduce la expresión del ácido nucleico diana y (ii) un agente de selectividad que es capaz de unirse con alta afinidad a un transportador de neurotransmisor. Los conjugados de la presente invención son útiles para la distribución de ácidos nucleicos a una célula de interés y de esta manera, para el tratamiento de enfermedades que requieren el descenso de la proteína codificada por el ácido nucleico diana así como para la distribución de agentes de imagen a las células para fines diagnósticos.
MX2012012214A 2010-04-19 2011-04-19 Composiciones y metodos para la distribucion selectiva de moleculas de oligonucleotidos a tipos especificos de neuronas. MX342764B (es)

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US20160235856A1 (en) 2016-08-18
CN103025357A (zh) 2013-04-03
KR20130103662A (ko) 2013-09-24
AU2019203887A1 (en) 2019-07-18
AR083715A1 (es) 2013-03-20
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MX2012012214A (es) 2013-02-07
RU2012149042A (ru) 2014-05-27
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