MX2019011272A - Composiciones y metodos para inmunooncologia. - Google Patents

Composiciones y metodos para inmunooncologia.

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Publication number
MX2019011272A
MX2019011272A MX2019011272A MX2019011272A MX2019011272A MX 2019011272 A MX2019011272 A MX 2019011272A MX 2019011272 A MX2019011272 A MX 2019011272A MX 2019011272 A MX2019011272 A MX 2019011272A MX 2019011272 A MX2019011272 A MX 2019011272A
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MX
Mexico
Prior art keywords
immunooncology
methods
compositions
reagents
directed
Prior art date
Application number
MX2019011272A
Other languages
English (en)
Inventor
Brogdon Jennifer
Yang Yi
Wei CHEN Ming-
Stewart Morag
Lim Hyungwook
HESSE Sarah
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019011272A publication Critical patent/MX2019011272A/es

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    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K35/14—Blood; Artificial blood
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
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    • C12N2750/14011—Parvoviridae
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    • C12N2800/00—Nucleic acids vectors
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
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Abstract

La presente descripción se refiere a sistemas de edición de genoma, reactivos y métodos para inmunooncología.
MX2019011272A 2017-03-22 2018-03-21 Composiciones y metodos para inmunooncologia. MX2019011272A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762475024P 2017-03-22 2017-03-22
PCT/US2018/023631 WO2018175636A2 (en) 2017-03-22 2018-03-21 Compositions and methods for immunooncology

Publications (1)

Publication Number Publication Date
MX2019011272A true MX2019011272A (es) 2019-10-24

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ID=61972210

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011272A MX2019011272A (es) 2017-03-22 2018-03-21 Composiciones y metodos para inmunooncologia.

Country Status (15)

Country Link
US (1) US11851659B2 (es)
EP (1) EP3601561A2 (es)
JP (2) JP2020513832A (es)
KR (1) KR20190130608A (es)
CN (1) CN110832075A (es)
AU (1) AU2018237159A1 (es)
BR (1) BR112019018124A2 (es)
CA (1) CA3054621A1 (es)
EA (1) EA201992232A1 (es)
IL (1) IL268684A (es)
MX (1) MX2019011272A (es)
PH (1) PH12019502171A1 (es)
RU (1) RU2019133280A (es)
SG (1) SG11201907434RA (es)
WO (1) WO2018175636A2 (es)

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WO2020069409A1 (en) * 2018-09-28 2020-04-02 Novartis Ag Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
WO2020223537A1 (en) * 2019-05-01 2020-11-05 Pact Pharma, Inc. Compositions and methods for the treatment of cancer using a cdb engineered t cell therapy
MX2021013311A (es) * 2019-05-06 2022-02-11 Thomas Malcolm Sistemas de suministro nanovesiculares hipoinmunitarios adaptados para tumores cancerosos.
EP4028521A1 (en) * 2019-12-09 2022-07-20 Caribou Biosciences, Inc. Crispr abasic restricted nucleotides and crispr accuracy via analogs
CA3171369A1 (en) * 2020-02-28 2021-09-02 Wisconsin Alumni Research Foundation Nonviral generation of genome edited chimeric antigen receptor t cells
EP4170020A1 (en) * 2020-06-17 2023-04-26 Kyoto University Chimeric antigen receptor-expressing immunocompetent cells
US20220193134A1 (en) * 2020-12-23 2022-06-23 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
CN117940138A (zh) * 2021-07-01 2024-04-26 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
CN113846070B (zh) * 2021-10-18 2023-05-16 翌圣生物科技(上海)股份有限公司 高活性的mTET2酶突变体、其编码DNA及其应用

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US11851659B2 (en) 2023-12-26
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