MX2015007550A - Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas. - Google Patents

Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas.

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Publication number
MX2015007550A
MX2015007550A MX2015007550A MX2015007550A MX2015007550A MX 2015007550 A MX2015007550 A MX 2015007550A MX 2015007550 A MX2015007550 A MX 2015007550A MX 2015007550 A MX2015007550 A MX 2015007550A MX 2015007550 A MX2015007550 A MX 2015007550A
Authority
MX
Mexico
Prior art keywords
methods
systems
delivery
optimization
engineering
Prior art date
Application number
MX2015007550A
Other languages
English (en)
Inventor
Zhang Feng
Ran Fei
HEIDENREICH Matthias
Swiech Lukasz
Original Assignee
Broad Inst Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49883289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015007550(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Broad Inst Inc filed Critical Broad Inst Inc
Publication of MX2015007550A publication Critical patent/MX2015007550A/es

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Abstract

La invención proporciona el suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y/o actividades de secuencias diana. Se proporcionan sistemas de suministro y tejidos u órganos que se escogen como sitios diana para el suministro. También se propórcionan vectores y sistemas vectoriales, donde algunos de los cuales codifican uno o más componentes de un complejo CRISPR, así como también métodos para el diseño y uso de tales vectores. También se proporcionan métodos para dirigir la formación del complejo CRISPR en células eucariotas para garantizar una mejor especificidad en lo que se refiere al reconocimiento de la diana y para evitar toxicidad y para editar o modificar un sitio diana en un locus genómico de interés con el fin de alterar o mejorar el estado de una enfermedad o afección.
MX2015007550A 2012-12-12 2013-12-12 Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas. MX2015007550A (es)

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US201261736527P 2012-12-12 2012-12-12
US201361748427P 2013-01-02 2013-01-02
US201361758468P 2013-01-30 2013-01-30
US201361769046P 2013-02-25 2013-02-25
US201361802174P 2013-03-15 2013-03-15
US201361791409P 2013-03-15 2013-03-15
US201361806375P 2013-03-28 2013-03-28
US201361814263P 2013-04-20 2013-04-20
US201361819803P 2013-05-06 2013-05-06
US201361828130P 2013-05-28 2013-05-28
US201361836123P 2013-06-17 2013-06-17
US201361835931P 2013-06-17 2013-06-17
US201361847537P 2013-07-17 2013-07-17
PCT/US2013/074667 WO2014093622A2 (en) 2012-12-12 2013-12-12 Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications

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CA2894681A1 (en) 2014-06-19
KR20150105956A (ko) 2015-09-18
HK1220725A1 (zh) 2017-05-12
WO2014093622A3 (en) 2014-08-07
US20210269831A1 (en) 2021-09-02
US20140242699A1 (en) 2014-08-28
SG10201707569YA (en) 2017-10-30
WO2014093622A8 (en) 2014-12-04
AU2013359199B2 (en) 2019-10-31
EP3327127A1 (en) 2018-05-30
JP2022040308A (ja) 2022-03-10

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