BR112019018124A2 - composições e métodos para imunooncologia - Google Patents

composições e métodos para imunooncologia Download PDF

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Publication number
BR112019018124A2
BR112019018124A2 BR112019018124A BR112019018124A BR112019018124A2 BR 112019018124 A2 BR112019018124 A2 BR 112019018124A2 BR 112019018124 A BR112019018124 A BR 112019018124A BR 112019018124 A BR112019018124 A BR 112019018124A BR 112019018124 A2 BR112019018124 A2 BR 112019018124A2
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BR
Brazil
Prior art keywords
methods
immunooncology
compositions
immunoncology
reagents
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BR112019018124A
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English (en)
Inventor
Lim Hyungwook
Brogdon Jennifer
Chen Ming-Wei
Stewart Morag
HESSE Sarah
Yang Yi
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Intellia Therapeutics Inc
Novartis Ag
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Application filed by Intellia Therapeutics Inc, Novartis Ag filed Critical Intellia Therapeutics Inc
Publication of BR112019018124A2 publication Critical patent/BR112019018124A2/pt

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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N2800/00—Nucleic acids vectors
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Abstract

a presente descrição refere-se a sistemas de edição gênica, reagentes e métodos para imunoncologia.
BR112019018124A 2017-03-22 2018-03-21 composições e métodos para imunooncologia BR112019018124A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762475024P 2017-03-22 2017-03-22
PCT/US2018/023631 WO2018175636A2 (en) 2017-03-22 2018-03-21 Compositions and methods for immunooncology

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BR112019018124A2 true BR112019018124A2 (pt) 2020-04-07

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BR112019018124A BR112019018124A2 (pt) 2017-03-22 2018-03-21 composições e métodos para imunooncologia

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US (1) US11851659B2 (pt)
EP (1) EP3601561A2 (pt)
JP (2) JP2020513832A (pt)
KR (1) KR20190130608A (pt)
CN (1) CN110832075A (pt)
AU (1) AU2018237159A1 (pt)
BR (1) BR112019018124A2 (pt)
CA (1) CA3054621A1 (pt)
EA (1) EA201992232A1 (pt)
IL (1) IL268684A (pt)
MX (1) MX2019011272A (pt)
PH (1) PH12019502171A1 (pt)
RU (1) RU2019133280A (pt)
SG (1) SG11201907434RA (pt)
WO (1) WO2018175636A2 (pt)

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WO2020069409A1 (en) * 2018-09-28 2020-04-02 Novartis Ag Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
EP3953379A4 (en) 2019-05-01 2023-05-31 PACT Pharma, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING MODIFIED TET2 T LYMPHOCYTE CELL THERAPY
MX2021013311A (es) * 2019-05-06 2022-02-11 Thomas Malcolm Sistemas de suministro nanovesiculares hipoinmunitarios adaptados para tumores cancerosos.
US20220348929A1 (en) * 2019-12-09 2022-11-03 Caribou Biosciences, Inc. Crispr abasic restricted nucleotides and crispr accuracy via analogs
EP4110356A4 (en) * 2020-02-28 2024-03-27 Wisconsin Alumni Res Found NON-VIRAL GENERATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS OBTAINED BY GENE EDITING
WO2021256522A1 (ja) * 2020-06-17 2021-12-23 国立大学法人京都大学 キメラ抗原受容体発現免疫担当細胞
US20220193134A1 (en) * 2020-12-23 2022-06-23 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
CN113846070B (zh) * 2021-10-18 2023-05-16 翌圣生物科技(上海)股份有限公司 高活性的mTET2酶突变体、其编码DNA及其应用

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