MX370018B - Metodos mejorados para la elaboracion de terapias celulares adoptivas. - Google Patents
Metodos mejorados para la elaboracion de terapias celulares adoptivas.Info
- Publication number
- MX370018B MX370018B MX2016013963A MX2016013963A MX370018B MX 370018 B MX370018 B MX 370018B MX 2016013963 A MX2016013963 A MX 2016013963A MX 2016013963 A MX2016013963 A MX 2016013963A MX 370018 B MX370018 B MX 370018B
- Authority
- MX
- Mexico
- Prior art keywords
- adoptive cell
- cell therapies
- improved methods
- manufacturing
- manufacturing adoptive
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants
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Abstract
La presente invención se refiere a composiciones y métodos para elaborar terapias celulares adoptivas; en modalidades particulares, la invención proporciona métodos para cosechar las poblaciones de células, aislar y activar PBMC, expandir células T y administrar la célula T terapéutica a un sujeto que lo necesita.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461984558P | 2014-04-25 | 2014-04-25 | |
PCT/US2015/027518 WO2015164745A1 (en) | 2014-04-25 | 2015-04-24 | Improved methods for manufacturing adoptive cell therapies |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016013963A MX2016013963A (es) | 2017-06-12 |
MX370018B true MX370018B (es) | 2019-11-28 |
Family
ID=54333268
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016013963A MX370018B (es) | 2014-04-25 | 2015-04-24 | Metodos mejorados para la elaboracion de terapias celulares adoptivas. |
MX2019014009A MX2019014009A (es) | 2014-04-25 | 2016-10-24 | Metodos mejorados para la elaboracion de terapias celulares adoptivas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019014009A MX2019014009A (es) | 2014-04-25 | 2016-10-24 | Metodos mejorados para la elaboracion de terapias celulares adoptivas. |
Country Status (25)
Country | Link |
---|---|
US (1) | US20170051252A1 (es) |
EP (2) | EP3738597A1 (es) |
JP (5) | JP6817069B2 (es) |
KR (3) | KR102161927B1 (es) |
CN (2) | CN110819595A (es) |
AU (2) | AU2015249376C1 (es) |
BR (1) | BR112016024957A2 (es) |
CA (1) | CA2946552A1 (es) |
CY (1) | CY1123142T1 (es) |
DK (1) | DK3134095T3 (es) |
ES (1) | ES2800906T3 (es) |
HR (1) | HRP20200978T1 (es) |
HU (1) | HUE049514T2 (es) |
IL (2) | IL248349B (es) |
LT (1) | LT3134095T (es) |
MX (2) | MX370018B (es) |
NZ (2) | NZ742136A (es) |
PL (1) | PL3134095T3 (es) |
PT (1) | PT3134095T (es) |
RS (1) | RS60544B1 (es) |
RU (1) | RU2741899C2 (es) |
SG (2) | SG11201608744VA (es) |
SI (1) | SI3134095T1 (es) |
WO (1) | WO2015164745A1 (es) |
ZA (2) | ZA201607175B (es) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2817625A2 (en) | 2012-02-23 | 2014-12-31 | Stage Cell Therapeutics GmbH | Chromatographic isolation of cells and other complex biological materials |
WO2014145152A2 (en) | 2013-03-15 | 2014-09-18 | Gpb Scientific, Llc | On-chip microfluidic processing of particles |
US10324011B2 (en) | 2013-03-15 | 2019-06-18 | The Trustees Of Princeton University | Methods and devices for high throughput purification |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
EP3988920A1 (en) | 2014-04-16 | 2022-04-27 | Juno Therapeutics GmbH | Methods, kits and apparatus for expanding a population of cells |
KR20220136455A (ko) | 2014-04-23 | 2022-10-07 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 치료용 면역 세포 집단의 단리, 배양 및 유전자 조작 방법 |
SG10201809379UA (en) | 2014-04-25 | 2018-11-29 | Bluebird Bio Inc | Mnd promoter chimeric antigen receptors |
US10479975B2 (en) | 2014-06-06 | 2019-11-19 | Bluebird Bio, Inc. | Methods of making T cell compositions |
CN106795217B (zh) | 2014-07-24 | 2021-08-06 | 蓝鸟生物公司 | Bcma嵌合抗原受体 |
SG11201704727WA (en) | 2014-12-12 | 2017-07-28 | Bluebird Bio Inc | Bcma chimeric antigen receptors |
US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
IL253149B2 (en) | 2014-12-29 | 2023-11-01 | Novartis Ag | Methods for preparing cells expressing a chimeric receptor antigen |
AU2016249005B2 (en) | 2015-04-17 | 2022-06-16 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
CA2986254A1 (en) | 2015-05-18 | 2016-11-24 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
FR3038324B1 (fr) | 2015-06-30 | 2020-10-30 | Lab Francais Du Fractionnement | Procede de cryoconservation de cellules a visee therapeutique |
CN109476722A (zh) | 2015-07-21 | 2019-03-15 | 诺华股份有限公司 | 用于改善免疫细胞的功效和扩张的方法 |
US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
TWI630934B (zh) * | 2015-10-14 | 2018-08-01 | 瑞典商神經毫微股份有限公司 | 移植醫藥設備到神經組織中的方法以及設備 |
MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
KR20180069067A (ko) | 2015-10-30 | 2018-06-22 | 엔비이-테라퓨틱스 아게 | 안티-ror1 항체 |
SG10202109655VA (en) | 2015-12-04 | 2021-10-28 | Novartis Ag | Compositions and methods for immunooncology |
US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
AU2016380262B2 (en) * | 2015-12-28 | 2023-02-09 | Novartis Ag | Methods of making chimeric antigen receptor -expressing cells |
TW201736399A (zh) | 2015-12-31 | 2017-10-16 | 財團法人生物技術開發中心 | 抗vegfr抗體及其應用 |
JP7000660B2 (ja) | 2016-01-20 | 2022-02-04 | ザ スクリプス リサーチ インスティテュート | Ror1抗体組成物及び関連の方法 |
JP2019510503A (ja) * | 2016-04-07 | 2019-04-18 | ブルーバード バイオ, インコーポレイテッド | キメラ抗原受容体t細胞組成物 |
CN115094036A (zh) * | 2016-04-08 | 2022-09-23 | 爱默蕾大学 | 使用基于细胞的疗法治疗癌症和传染病的方法 |
CN105907790A (zh) * | 2016-06-21 | 2016-08-31 | 林志国 | 特异性识别EGFRvⅢ的含CD70嵌合抗原受体修饰T细胞的制备方法 |
WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
KR20190058509A (ko) | 2016-10-07 | 2019-05-29 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 t-세포 수용체 리프로그래밍을 위한 조성물 및 방법 |
US20200306299A9 (en) * | 2016-10-21 | 2020-10-01 | Georgia Tech Research Corporation | Methods and Systems for T Cell Expansion |
CN110381961A (zh) * | 2016-10-24 | 2019-10-25 | Gpb科学有限责任公司 | 用于治疗用途的细胞和组合物的制备中的确定性侧向位移 |
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