SI4019041T1 - Obladovanje toksičnosti za protitumorsko delovanje CARS - Google Patents
Obladovanje toksičnosti za protitumorsko delovanje CARSInfo
- Publication number
- SI4019041T1 SI4019041T1 SI201332036T SI201332036T SI4019041T1 SI 4019041 T1 SI4019041 T1 SI 4019041T1 SI 201332036 T SI201332036 T SI 201332036T SI 201332036 T SI201332036 T SI 201332036T SI 4019041 T1 SI4019041 T1 SI 4019041T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cars
- tumor activity
- toxicity management
- toxicity
- management
- Prior art date
Links
- 101150102779 Cars1 gene Proteins 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671482P | 2012-07-13 | 2012-07-13 | |
| US201361782982P | 2013-03-14 | 2013-03-14 | |
| EP21215762.2A EP4019041B1 (en) | 2012-07-13 | 2013-07-12 | Toxicity management for anti-tumor activity of cars |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4019041T1 true SI4019041T1 (sl) | 2023-04-28 |
Family
ID=49916566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201332036T SI4019041T1 (sl) | 2012-07-13 | 2013-07-12 | Obladovanje toksičnosti za protitumorsko delovanje CARS |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20150202286A1 (sl) |
| EP (4) | EP3338794B1 (sl) |
| JP (5) | JP6382191B2 (sl) |
| KR (1) | KR102204029B1 (sl) |
| CN (4) | CN108379586A (sl) |
| AU (2) | AU2013289967B2 (sl) |
| BR (1) | BR112015000660A8 (sl) |
| CA (1) | CA2878928C (sl) |
| DK (3) | DK2872171T3 (sl) |
| EA (1) | EA201590210A1 (sl) |
| ES (3) | ES2941370T3 (sl) |
| FI (1) | FI4019041T3 (sl) |
| HK (1) | HK1253365A1 (sl) |
| HR (1) | HRP20230297T1 (sl) |
| HU (3) | HUE053556T2 (sl) |
| IN (1) | IN2014DN11155A (sl) |
| LT (3) | LT4019041T (sl) |
| MX (2) | MX2015000438A (sl) |
| PL (2) | PL2872171T3 (sl) |
| PT (3) | PT3338794T (sl) |
| SI (1) | SI4019041T1 (sl) |
| WO (1) | WO2014011984A1 (sl) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20230297T1 (hr) | 2012-07-13 | 2023-05-12 | The Trustees Of The University Of Pennsylvania | UPRAVLJANJE TOKSIČNOŠĆU ZA ANTI-TUMORSKO DJELOVANJE CAR-a |
| KR102313997B1 (ko) | 2013-02-20 | 2021-10-20 | 노파르티스 아게 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向 |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| JP6779785B2 (ja) | 2013-12-19 | 2020-11-04 | ノバルティス アーゲー | ヒトメソテリンキメラ抗原受容体およびその使用 |
| WO2015090229A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Regulatable chimeric antigen receptor |
| US11028143B2 (en) | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
| PL3129470T3 (pl) | 2014-04-07 | 2021-11-29 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
| WO2015164354A1 (en) * | 2014-04-21 | 2015-10-29 | The Childen's Hospital Of Philadelphia | Compositions and methods for treating cytokine-related disorders |
| KR102594343B1 (ko) | 2014-07-21 | 2023-10-26 | 노파르티스 아게 | Cd33 키메라 항원 수용체를 사용한 암의 치료 |
| BR112017001183A2 (pt) | 2014-07-21 | 2017-11-28 | Novartis Ag | tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado |
| SG11201700418VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using a cll-1 chimeric antigen receptor |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| CN107108744B (zh) | 2014-08-19 | 2020-09-25 | 诺华股份有限公司 | 抗cd123嵌合抗原受体(car)用于癌症治疗 |
| BR112017005390A2 (pt) | 2014-09-17 | 2017-12-12 | Novartis Ag | células citotóxicas alvo com receptores quiméricos para imunoterapia adotiva |
| JP6815992B2 (ja) * | 2014-10-08 | 2021-01-20 | ノバルティス アーゲー | キメラ抗原受容体療法に対する治療応答性を予測するバイオマーカーおよびその使用 |
| CN107567461A (zh) | 2014-12-29 | 2018-01-09 | 诺华股份有限公司 | 制备嵌合抗原受体表达细胞的方法 |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| ES2926384T3 (es) * | 2015-02-06 | 2022-10-25 | Nat Univ Singapore | Métodos para mejorar la eficacia de células inmunitarias terapéuticas |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016132366A1 (en) * | 2015-02-18 | 2016-08-25 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016164731A2 (en) | 2015-04-08 | 2016-10-13 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
| EP4234685A3 (en) | 2015-04-17 | 2023-09-06 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| CN107708811B (zh) | 2015-04-21 | 2021-04-30 | 恩立夫克治疗有限责任公司 | 治疗性汇集的血液凋亡细胞制剂与其用途 |
| JP7146632B2 (ja) | 2015-07-21 | 2022-10-04 | ノバルティス アーゲー | 免疫細胞の有効性および増大を改善する方法 |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
| CN108780084B (zh) * | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
| MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
| CN109152824B (zh) | 2015-11-27 | 2022-12-06 | 卡瑟里克斯私人有限公司 | 经遗传修饰的细胞及其用途 |
| WO2017096331A1 (en) * | 2015-12-04 | 2017-06-08 | Juno Therapeutics, Inc. | Methods and compositions related to toxicity associated with cell therapy |
| WO2017112741A1 (en) | 2015-12-22 | 2017-06-29 | Novartis Ag | Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy |
| JP6853514B2 (ja) * | 2015-12-27 | 2021-03-31 | 国立大学法人東海国立大学機構 | 炎症性サイトカインの産生が抑制されるキメラ抗原受容体遺伝子改変リンパ球 |
| JP6884155B2 (ja) * | 2016-02-18 | 2021-06-09 | エンリヴェックス セラピューティクス リミテッド | 癌治療のための併用免疫療法及びサイトカイン制御療法 |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| ES2907557T3 (es) | 2016-03-22 | 2022-04-25 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Métodos de intervención temprana para prevenir o mejorar la toxicidad |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| CN109414512A (zh) | 2016-04-22 | 2019-03-01 | 科济生物医药（上海）有限公司 | 用于细胞免疫疗法的组合物和方法 |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| MA45341A (fr) * | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| AU2017292936C1 (en) * | 2016-07-08 | 2024-05-02 | Exuma Biotech Corp | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| JP7219376B2 (ja) | 2016-07-15 | 2023-02-08 | ノバルティス アーゲー | キメラ抗原受容体をキナーゼ阻害薬と併用して使用したサイトカイン放出症候群の治療及び予防 |
| EP3490590A2 (en) * | 2016-08-01 | 2019-06-05 | Novartis AG | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule |
| BR112019006781A2 (pt) | 2016-10-07 | 2019-07-30 | Novartis Ag | receptores de antígeno quiméricos para o tratamento de câncer |
| CN106636090B (zh) * | 2016-10-11 | 2019-08-09 | 上海优卡迪生物医药科技有限公司 | 人源白细胞介素6的siRNA、重组表达CAR-T载体及其构建方法和应用 |
| CA3045339A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
| AU2017368333A1 (en) * | 2016-12-03 | 2019-06-13 | Juno Therapeutics, Inc. | Methods for determining CAR-T cells dosing |
| CN108148863B (zh) * | 2016-12-05 | 2019-12-17 | 上海优卡迪生物医药科技有限公司 | 一种封闭il6r的用于缓解crs的car-t转基因载体及其构建方法和应用 |
| CN108250301A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多靶点嵌合抗原受体 |
| US11535662B2 (en) | 2017-01-26 | 2022-12-27 | Novartis Ag | CD28 compositions and methods for chimeric antigen receptor therapy |
| CN110612119A (zh) | 2017-02-07 | 2019-12-24 | 西雅图儿童医院（Dba西雅图儿童研究所） | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| KR20200010179A (ko) * | 2017-02-27 | 2020-01-30 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법에 있어서 투약과 관련된 조성물, 제조 물품 및 방법 |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| EA201992232A1 (ru) | 2017-03-22 | 2020-05-14 | Новартис Аг | Композиции и способы для иммуноонкологии |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| WO2018204413A1 (en) * | 2017-05-01 | 2018-11-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Targeted cytokine blockades for car-t therapy |
| CA3065120A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| KR20200014418A (ko) * | 2017-06-08 | 2020-02-10 | 엔리벡스 테라퓨틱스 리미티드 | 암 요법을 위한 치료학적 세포자살성 세포 |
| EP3665270A4 (en) | 2017-08-10 | 2021-04-21 | National University of Singapore | T-LYMPHOCYTES T-LYMPHOCYTE RECEPTOR-DEFICIENT CHEMERICAL ANTIGEN RECEPTOR AND METHODS OF USE |
| US10870703B2 (en) | 2017-10-02 | 2020-12-22 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
| AU2018351046A1 (en) * | 2017-10-18 | 2020-04-30 | Kite Pharma, Inc. | Methods of administering chimeric antigen receptor immunotherapy |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| JP2021512147A (ja) | 2018-01-22 | 2021-05-13 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | Ｃａｒ ｔ細胞の使用方法 |
| CN108300807A (zh) * | 2018-02-07 | 2018-07-20 | 安徽古生物科技有限公司 | 针对第四代嵌合抗原受体car载体pcr鉴定的方法 |
| WO2019170845A1 (en) * | 2018-03-09 | 2019-09-12 | Ospedale San Raffaele S.R.L. | Il-1 antagonist and toxicity induced by cell therapy |
| CA3093827A1 (en) * | 2018-03-14 | 2019-09-19 | Celledit Llc | Modification of immune cells for reducing toxicity and uses thereof in adoptive cell therapy |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| ES2959645T3 (es) * | 2018-06-01 | 2024-02-27 | Mayo Found Medical Education & Res | Materiales y métodos para el tratamiento del cáncer |
| BR112020025048A2 (pt) | 2018-06-13 | 2021-04-06 | Novartis Ag | Receptores de antígeno quimérico de bcma e usos dos mesmos |
| CN108949759B (zh) * | 2018-07-23 | 2021-06-01 | 合肥一兮生物科技有限公司 | 敲减人IL-15的siRNA、CD19 CAR表达载体、CAR-T细胞及构建方法和应用 |
| EP3835320A4 (en) * | 2018-08-10 | 2022-06-01 | Eutilex Co., Ltd. | BINDING OF CHEMERA ANTIGEN RECEPTOR TO HLA-DR, AND CAR-T CELL |
| US20220348682A1 (en) | 2018-08-30 | 2022-11-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| BR112021004489A2 (pt) * | 2018-09-10 | 2021-07-20 | Humanigen, Inc. | métodos de tratamento de toxicidade relacionada à imunoterapia usando um antagonista de gm-csf |
| BR112021008263A2 (pt) * | 2018-10-31 | 2021-08-10 | Humanigen, Inc. | materiais e métodos para tratamento de câncer |
| MX2021005734A (es) * | 2018-11-16 | 2021-09-10 | Juno Therapeutics Inc | Metodos de dosificacion de celulas t modificadas para el tratamiento de malignidades de celulas b. |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| WO2020123691A2 (en) | 2018-12-12 | 2020-06-18 | Kite Pharma, Inc | Chimeric antigen and t cell receptors and methods of use |
| EP3908613A4 (en) * | 2019-01-07 | 2022-10-19 | Celluris Participações Ltda. | TANDEM BISPECIFIC CAR RECEPTOR AND METHOD FOR MODULATING A TUMOR MICROENVIRONMENT |
| CN112430579A (zh) * | 2019-08-26 | 2021-03-02 | 深圳宾德生物技术有限公司 | 靶向Her2并干扰IL-6表达的嵌合抗原受体T细胞及其制备方法和应用 |
| WO2021168376A1 (en) * | 2020-02-20 | 2021-08-26 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| EP3988116A1 (en) * | 2020-10-23 | 2022-04-27 | Consejo Superior De Investigaciones Científicas (CSIC) | Methods and compositions for the treatment of hematologic malignancies |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237638A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| CA3202891A1 (en) | 2021-01-28 | 2022-08-04 | Kara Olson | Compositions and methods for treating cytokine release syndrome |
| WO2023004055A1 (en) * | 2021-07-21 | 2023-01-26 | The Cleveland Clinic Foundation | Metabolic and inflammatory markers for car-t cell therapy |
| WO2023159001A1 (en) * | 2022-02-15 | 2023-08-24 | Kite Pharma, Inc. | Predicting adverse events from immunotherapy |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| WO1988008534A1 (en) | 1987-04-27 | 1988-11-03 | Unilever Plc | Immunoassays and devices therefor |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6656745B1 (en) | 2000-06-02 | 2003-12-02 | Francis X. Cole | Devices and methods for a multi-level, semi-quantitative immunodiffusion assay |
| AU2008207646A1 (en) * | 2001-10-04 | 2008-09-25 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| JP4895811B2 (ja) * | 2003-09-11 | 2012-03-14 | ケミア，インコーポレイテッド | サイトカイン阻害剤 |
| DE602004030586D1 (de) * | 2003-09-15 | 2011-01-27 | Oklahoma Med Res Found | Verfahren zur verwendung von cytokintests zur diagnose, behandlung und beurteilung von ankyloider spondylitis |
| US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US7935340B2 (en) | 2007-05-21 | 2011-05-03 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US20090004189A1 (en) * | 2007-06-18 | 2009-01-01 | Genentech, Inc. | Biological markers predictive of rheumatoid arthritis response to b-cell antagonists |
| EP3338799B1 (en) * | 2008-11-25 | 2021-04-07 | Vitaeris Inc. | Antibodies to il-6 and use thereof |
| US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| WO2010075249A2 (en) * | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| WO2011066374A2 (en) | 2009-11-24 | 2011-06-03 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| SG10201510092QA (en) | 2010-12-09 | 2016-01-28 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| EP2872717B1 (en) | 2012-07-04 | 2017-06-28 | In & Tec S.r.l. | Hinge for rotatably moving a door, in particular a reinforced door |
| HRP20230297T1 (hr) | 2012-07-13 | 2023-05-12 | The Trustees Of The University Of Pennsylvania | UPRAVLJANJE TOKSIČNOŠĆU ZA ANTI-TUMORSKO DJELOVANJE CAR-a |
-
2013
- 2013-07-12 HR HRP20230297TT patent/HRP20230297T1/hr unknown
- 2013-07-12 PL PL13817210T patent/PL2872171T3/pl unknown
- 2013-07-12 US US14/410,659 patent/US20150202286A1/en not_active Abandoned
- 2013-07-12 SI SI201332036T patent/SI4019041T1/sl unknown
- 2013-07-12 LT LTEP21215762.2T patent/LT4019041T/lt unknown
- 2013-07-12 CA CA2878928A patent/CA2878928C/en active Active
- 2013-07-12 EP EP18154090.7A patent/EP3338794B1/en not_active Revoked
- 2013-07-12 AU AU2013289967A patent/AU2013289967B2/en active Active
- 2013-07-12 DK DK13817210.1T patent/DK2872171T3/da active
- 2013-07-12 WO PCT/US2013/050267 patent/WO2014011984A1/en active Application Filing
- 2013-07-12 KR KR1020157003078A patent/KR102204029B1/ko active IP Right Grant
- 2013-07-12 EA EA201590210A patent/EA201590210A1/ru unknown
- 2013-07-12 CN CN201810348463.5A patent/CN108379586A/zh active Pending
- 2013-07-12 BR BR112015000660A patent/BR112015000660A8/pt not_active Application Discontinuation
- 2013-07-12 LT LTEP18154090.7T patent/LT3338794T/lt unknown
- 2013-07-12 PT PT181540907T patent/PT3338794T/pt unknown
- 2013-07-12 ES ES21215762T patent/ES2941370T3/es active Active
- 2013-07-12 DK DK18154090.7T patent/DK3338794T3/da active
- 2013-07-12 HU HUE13817210A patent/HUE053556T2/hu unknown
- 2013-07-12 MX MX2015000438A patent/MX2015000438A/es active IP Right Grant
- 2013-07-12 CN CN201380037301.5A patent/CN104427997B/zh active Active
- 2013-07-12 EP EP21215762.2A patent/EP4019041B1/en active Active
- 2013-07-12 LT LTEP13817210.1T patent/LT2872171T/lt unknown
- 2013-07-12 PL PL21215762.2T patent/PL4019041T3/pl unknown
- 2013-07-12 ES ES18154090T patent/ES2778701T3/es active Active
- 2013-07-12 CN CN202010124303.XA patent/CN111481667A/zh active Pending
- 2013-07-12 FI FIEP21215762.2T patent/FI4019041T3/fi active
- 2013-07-12 HU HUE21215762A patent/HUE061555T2/hu unknown
- 2013-07-12 DK DK21215762.2T patent/DK4019041T3/da active
- 2013-07-12 PT PT138172101T patent/PT2872171T/pt unknown
- 2013-07-12 HU HUE18154090A patent/HUE048947T2/hu unknown
- 2013-07-12 CN CN202010124264.3A patent/CN111467494B/zh active Active
- 2013-07-12 IN IN11155DEN2014 patent/IN2014DN11155A/en unknown
- 2013-07-12 EP EP13817210.1A patent/EP2872171B1/en active Active
- 2013-07-12 EP EP20158930.6A patent/EP3721901A1/en active Pending
- 2013-07-12 PT PT212157622T patent/PT4019041T/pt unknown
- 2013-07-12 JP JP2015521838A patent/JP6382191B2/ja active Active
- 2013-07-12 ES ES13817210T patent/ES2859522T3/es active Active
-
2015
- 2015-01-09 MX MX2019014761A patent/MX2019014761A/es unknown
-
2018
- 2018-04-26 JP JP2018085102A patent/JP6563554B2/ja active Active
- 2018-04-26 US US15/963,728 patent/US11273219B2/en active Active
- 2018-05-07 US US15/972,972 patent/US10603378B2/en active Active
- 2018-06-04 AU AU2018203924A patent/AU2018203924B2/en active Active
- 2018-08-09 JP JP2018150287A patent/JP2019006782A/ja not_active Withdrawn
- 2018-10-03 HK HK18112660.4A patent/HK1253365A1/zh unknown
-
2019
- 2019-07-24 JP JP2019136179A patent/JP7034125B2/ja active Active
-
2022
- 2022-02-22 US US17/677,208 patent/US20230013642A1/en active Pending
- 2022-03-01 JP JP2022030740A patent/JP2022066304A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1253365A1 (zh) | 對cars的抗腫瘤活性的毒性管理 | |
| HK1203884A1 (en) | Atomiser system | |
| GB201300443D0 (en) | Track system | |
| HK1209391A1 (zh) | 車輛定位 | |
| HK1204609A1 (en) | Carbamate urea derivatives | |
| HK1207566A1 (en) | Compositions for improvement of brain function | |
| HK1215251A1 (zh) | 具有增強抗生素活性的活性的螺異噁唑啉化合物 | |
| HK1210165A1 (en) | Methanethione compounds having antiviral activity | |
| EP2889035A4 (en) | ANTI-TUMOR AGENT | |
| HU4381U (en) | Arrangement for divided enery-production | |
| EP2812807A4 (en) | REAL PROPERTY OF SHARED DATA | |
| GB201203391D0 (en) | Medico-surgical assemblies | |
| GB201206047D0 (en) | Ticketless travel system | |
| SG11201406292UA (en) | Elevated track system | |
| GB201203388D0 (en) | Medico-surgical assemblies | |
| IL220950A (en) | A system for simultaneously establishing data communication channels as a result of event reporting | |
| GB201208751D0 (en) | Anti-malarial compounds |