BR112016022318A2 - método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo - Google Patents

método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo

Info

Publication number
BR112016022318A2
BR112016022318A2 BR112016022318A BR112016022318A BR112016022318A2 BR 112016022318 A2 BR112016022318 A2 BR 112016022318A2 BR 112016022318 A BR112016022318 A BR 112016022318A BR 112016022318 A BR112016022318 A BR 112016022318A BR 112016022318 A2 BR112016022318 A2 BR 112016022318A2
Authority
BR
Brazil
Prior art keywords
treatment
antibody
retinal diseases
pharmaceutical composition
compositions
Prior art date
Application number
BR112016022318A
Other languages
English (en)
Inventor
Nixon Andrew
j sexton Daniel
P Conley Gregory
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of BR112016022318A2 publication Critical patent/BR112016022318A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

composições compreendendo um ou mais anticorpos que especificamente se ligam à calicreína plasmática ativa (por exemplo, calicreína plasmática humana) e métodos de uso de tais composições para o tratamento de doenças da retina, tal como edema macular diabético, são divulgadas neste documento.
BR112016022318A 2014-03-27 2015-03-26 método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo BR112016022318A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461971170P 2014-03-27 2014-03-27
PCT/US2015/022715 WO2015148790A1 (en) 2014-03-27 2015-03-26 Compositions and methods for treatment of diabetic macular edema

Publications (1)

Publication Number Publication Date
BR112016022318A2 true BR112016022318A2 (pt) 2017-10-31

Family

ID=54189389

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016022318A BR112016022318A2 (pt) 2014-03-27 2015-03-26 método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo

Country Status (10)

Country Link
US (3) US10428158B2 (pt)
EP (1) EP3122782A4 (pt)
JP (4) JP6719384B2 (pt)
KR (2) KR102555955B1 (pt)
CN (1) CN106459210A (pt)
AU (2) AU2015235967B2 (pt)
BR (1) BR112016022318A2 (pt)
CA (1) CA2942713A1 (pt)
IL (2) IL295414A (pt)
WO (1) WO2015148790A1 (pt)

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SI2521568T1 (sl) 2010-01-06 2019-01-31 Dyax Corp. Proteini, ki vežejo plazemski kalikrein
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
CA2823776A1 (en) 2011-01-06 2012-07-12 Dyax Corp. Plasma kallikrein binding proteins
CN105051068A (zh) 2013-03-15 2015-11-11 戴埃克斯有限公司 抗血浆激肽释放酶抗体
JP6845012B2 (ja) * 2014-01-21 2021-03-17 ダイアックス コーポレーション 遺伝性血管浮腫の治療における血漿カリクレイン結合タンパク質およびその使用
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
KR20180073680A (ko) 2015-11-03 2018-07-02 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 포도막염 및 황반 부종의 치료를 위한 il6r 항체를 포함하는 조성물 및 이를 이용하는 방법
RU2747193C2 (ru) * 2015-11-03 2021-04-29 Санофи Байотекнолоджи Композиции, содержащие антитела к il6r, для лечения увеита и макулярного отека, и способы их применения
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
US20200109214A1 (en) * 2018-08-30 2020-04-09 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
WO2020160465A1 (en) 2019-01-31 2020-08-06 Sanofi Biotechnology Anti-il-6 receptor antibody for treating juvenile idiopathic arthritis
CA3136326A1 (en) * 2019-04-08 2020-10-15 Biocryst Pharmaceuticals, Inc. Plasma kallikrein inhibitors and methods of use thereof in ocular disorders
KR20230137410A (ko) * 2021-01-28 2023-10-04 아스트리아 테라퓨틱스, 인크. 혈장 칼리크레인 항체 및 이의 용도

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