DK225488D0 - Polypeptid - Google Patents
PolypeptidInfo
- Publication number
- DK225488D0 DK225488D0 DK225488A DK225488A DK225488D0 DK 225488 D0 DK225488 D0 DK 225488D0 DK 225488 A DK225488 A DK 225488A DK 225488 A DK225488 A DK 225488A DK 225488 D0 DK225488 D0 DK 225488D0
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptide
- serine proteases
- profile against
- inhibition profile
- against serine
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical class C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK225488A DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Polypeptid |
| EP89304122A EP0339942B1 (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and process for the production thereof |
| AT89304122T ATE103295T1 (de) | 1988-04-26 | 1989-04-25 | Aprotinin-analoge und verfahren zu ihrer herstellung. |
| ES89304122T ES2061983T3 (es) | 1988-04-26 | 1989-04-25 | Analogos de aprotinina y procedimiento para su produccion. |
| PCT/DK1989/000096 WO1989010374A1 (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and a process for the production thereof |
| AU35603/89A AU619553B2 (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and a process for the production thereof |
| JP1505101A JP2810743B2 (ja) | 1988-04-26 | 1989-04-25 | アプロチニン同族体およびその製造方法 |
| IE133489A IE64230B1 (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and process for the production thereof |
| DE68914022T DE68914022T2 (de) | 1988-04-26 | 1989-04-25 | Aprotinin-Analoge und Verfahren zu ihrer Herstellung. |
| US07/598,737 US5373090A (en) | 1988-04-26 | 1989-04-25 | Aprotinin analogues and a process for the production thereof |
| NZ228896A NZ228896A (en) | 1988-04-26 | 1989-04-26 | Aprotinin analogues having a selected inhibition profile against serine proteases, the analogues are produced recombinantly in a suitable yeast strain |
| ZA893075A ZA893075B (en) | 1988-04-26 | 1989-04-26 | Aprotinin analogues and process for the production thereof |
| FI905275A FI93964C (fi) | 1988-04-26 | 1990-10-25 | Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi |
| NO904622A NO302950B1 (no) | 1988-04-26 | 1990-10-25 | Fremgangsmåte for fremstilling av aprotininanaloger |
| DK257990A DK171417B1 (da) | 1988-04-26 | 1990-10-26 | Aprotininalaloger med Ala eller Gly i position 17 og fremgangsmåde til fremstilling deraf |
| US08/084,718 US5591603A (en) | 1987-08-28 | 1993-06-23 | Process for preparing aprotinin and aprotinin analogs in yeast cells |
| US08/443,977 US5621074A (en) | 1987-08-28 | 1995-05-18 | Aprotinin analogs |
| US08/443,976 US5618915A (en) | 1987-08-28 | 1995-05-18 | Aprotinin analogs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK225488A DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Polypeptid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK225488D0 true DK225488D0 (da) | 1988-04-26 |
Family
ID=8111114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK225488A DK225488D0 (da) | 1987-08-28 | 1988-04-26 | Polypeptid |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5373090A (da) |
| EP (1) | EP0339942B1 (da) |
| JP (1) | JP2810743B2 (da) |
| AT (1) | ATE103295T1 (da) |
| AU (1) | AU619553B2 (da) |
| DE (1) | DE68914022T2 (da) |
| DK (1) | DK225488D0 (da) |
| ES (1) | ES2061983T3 (da) |
| FI (1) | FI93964C (da) |
| IE (1) | IE64230B1 (da) |
| NO (1) | NO302950B1 (da) |
| NZ (1) | NZ228896A (da) |
| WO (1) | WO1989010374A1 (da) |
| ZA (1) | ZA893075B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
| DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
| IL99585A0 (en) * | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
| DE69233769D1 (de) | 1991-03-01 | 2009-09-24 | Dyax Corp | Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon |
| IL104314A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| EP0651766A4 (en) * | 1992-07-13 | 1996-07-31 | Corvas Int Inc | INHIBITORS OF FACTOR Xa, DERIVED FROM THE INHIBITOR OF THE PANCREATIC TRYPSON FROM BEEF. |
| WO1994007528A1 (en) * | 1992-09-25 | 1994-04-14 | Corvas International, Inc. | Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia-tissue factor complex |
| PT1489097E (pt) * | 1994-01-11 | 2012-01-04 | Dyax Corp | Inibidores de plasmina humana derivados de domínios kunitz e ácidos nucleicos codificando os mesmos |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| DE19629982A1 (de) | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
| DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2709103T3 (es) | 2002-08-28 | 2019-04-15 | Dyax Corp | Métodos para conservar órganos y tejidos |
| WO2004063337A2 (en) * | 2003-01-07 | 2004-07-29 | Dyax Corporation | Kunitz domain library |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| DK1663281T3 (da) * | 2003-08-29 | 2014-03-17 | Dyax Corp | Poly-pegylerede proteaseinhibitorer |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20060218667A1 (en) * | 2004-10-12 | 2006-09-28 | Vojdani Fakhrieh S | Plant-produced recombinant aprotinin and aprotinin variants |
| JP5118492B2 (ja) | 2004-12-23 | 2013-01-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 血栓の形成の防止および／または安定化の防止 |
| EP2195010A4 (en) * | 2007-08-21 | 2012-03-14 | Genzyme Corp | TREATMENT WITH INHIBITORS OF KALLIKREINE |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| RS62853B1 (sr) | 2010-01-06 | 2022-02-28 | Takeda Pharmaceuticals Co | Proteini koji vezuju kalikrein plazme |
| AU2012204202A1 (en) | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| AU2015235967B2 (en) | 2014-03-27 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Compositions and methods for treatment of diabetic macular edema |
| CN116077648A (zh) | 2015-12-11 | 2023-05-09 | 武田药品工业株式会社 | 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途 |
| MX2022008649A (es) | 2020-01-13 | 2022-09-23 | Takeda Pharmaceuticals Co | Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
| GB2188933A (en) * | 1986-04-10 | 1987-10-14 | Bayer Ag | Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby |
| DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
-
1988
- 1988-04-26 DK DK225488A patent/DK225488D0/da unknown
-
1989
- 1989-04-25 EP EP89304122A patent/EP0339942B1/en not_active Expired - Lifetime
- 1989-04-25 WO PCT/DK1989/000096 patent/WO1989010374A1/en not_active Ceased
- 1989-04-25 JP JP1505101A patent/JP2810743B2/ja not_active Expired - Fee Related
- 1989-04-25 AU AU35603/89A patent/AU619553B2/en not_active Ceased
- 1989-04-25 US US07/598,737 patent/US5373090A/en not_active Expired - Lifetime
- 1989-04-25 IE IE133489A patent/IE64230B1/en not_active IP Right Cessation
- 1989-04-25 ES ES89304122T patent/ES2061983T3/es not_active Expired - Lifetime
- 1989-04-25 DE DE68914022T patent/DE68914022T2/de not_active Expired - Fee Related
- 1989-04-25 AT AT89304122T patent/ATE103295T1/de not_active IP Right Cessation
- 1989-04-26 ZA ZA893075A patent/ZA893075B/xx unknown
- 1989-04-26 NZ NZ228896A patent/NZ228896A/xx unknown
-
1990
- 1990-10-25 FI FI905275A patent/FI93964C/fi not_active IP Right Cessation
- 1990-10-25 NO NO904622A patent/NO302950B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ228896A (en) | 1991-08-27 |
| JPH03504009A (ja) | 1991-09-05 |
| WO1989010374A1 (en) | 1989-11-02 |
| IE64230B1 (en) | 1995-07-26 |
| EP0339942A3 (en) | 1990-05-30 |
| AU3560389A (en) | 1989-11-24 |
| NO302950B1 (no) | 1998-05-11 |
| US5373090A (en) | 1994-12-13 |
| ATE103295T1 (de) | 1994-04-15 |
| AU619553B2 (en) | 1992-01-30 |
| ZA893075B (en) | 1989-12-27 |
| JP2810743B2 (ja) | 1998-10-15 |
| DE68914022D1 (de) | 1994-04-28 |
| DE68914022T2 (de) | 1994-07-07 |
| EP0339942A2 (en) | 1989-11-02 |
| FI93964C (fi) | 1995-06-26 |
| FI93964B (fi) | 1995-03-15 |
| ES2061983T3 (es) | 1994-12-16 |
| IE891334L (en) | 1989-10-26 |
| FI905275A0 (fi) | 1990-10-25 |
| NO904622D0 (no) | 1990-10-25 |
| EP0339942B1 (en) | 1994-03-23 |
| NO904622L (no) | 1990-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK225488D0 (da) | Polypeptid | |
| FI950168L (fi) | Korkea-alkaliset seriiniproteaasit | |
| FI892714A0 (fi) | Rekombinant-coccidiosisvaccin. | |
| EP0602069A4 (en) | RETROVIRASE PROTEASE INHIBITORS. | |
| DK492788D0 (da) | Peptidsynteseapparat | |
| FI925787L (fi) | Proteolytiska enzymers sackarinderivatinhibitorer | |
| FI892677L (fi) | Polypeptidfoereningar. | |
| DK633289A (da) | Retrovirale proteasehaemmere | |
| FI893833A7 (fi) | Rekombinant aktivator foer naturliga doedarceller. | |
| ATA37688A (de) | Uhf-rueckkopplungsoszillator | |
| IL92551A0 (en) | Anticoagulant peptides | |
| NO890174D0 (no) | Rekombinante interleukin-1alfa-polypeptider. | |
| FI906140A7 (fi) | Retroviraalisten proteaasien inhibiittoreita | |
| TW336938B (en) | Calcium channel blocking polypeptides from filistata hibernalis | |
| DE68922014D1 (de) | Protease. | |
| FR2631675B1 (fr) | Vanne a soufflet | |
| DE69014021D1 (de) | Vorspannungsversorgungsschaltung. | |
| ATE42082T1 (de) | Verschleissschutzelement. | |
| DK257990A (da) | Aprotininalaloger og fremgangsmaade til fremstilling deraf | |
| FI942623L (fi) | Keinotekoisen proteolyyttisen pilkkomiskohdan sisältävät yhdistelmävirukset | |
| SE9100284D0 (sv) | Novel peptide | |
| KR900701833A (ko) | 맥관형성 인자를 조력하는 맥관형성 조력 펩타이드(angiogenic potentiationg peptide) | |
| KR900002041U (ko) | 다단 바이어스 공급회로 | |
| DK0717778T3 (da) | Höjalkalisk serinprotease | |
| KR900013609U (ko) | 바이어스 공급장치 |