FI905275A0 - Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi - Google Patents

Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi

Info

Publication number
FI905275A0
FI905275A0 FI905275A FI905275A FI905275A0 FI 905275 A0 FI905275 A0 FI 905275A0 FI 905275 A FI905275 A FI 905275A FI 905275 A FI905275 A FI 905275A FI 905275 A0 FI905275 A0 FI 905275A0
Authority
FI
Finland
Prior art keywords
preparation
pharmacologically active
aprotinin analogs
active aprotinin
analogs
Prior art date
Application number
FI905275A
Other languages
English (en)
Swedish (sv)
Other versions
FI93964C (fi
FI93964B (fi
Inventor
Kjeld Norris
Lars Christian Petersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI905275A0 publication Critical patent/FI905275A0/fi
Application granted granted Critical
Publication of FI93964B publication Critical patent/FI93964B/fi
Publication of FI93964C publication Critical patent/FI93964C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI905275A 1988-04-26 1990-10-25 Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi FI93964C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK225488A DK225488D0 (da) 1988-04-26 1988-04-26 Polypeptid
DK225488 1988-04-26
PCT/DK1989/000096 WO1989010374A1 (en) 1988-04-26 1989-04-25 Aprotinin analogues and a process for the production thereof
DK8900096 1989-04-25

Publications (3)

Publication Number Publication Date
FI905275A0 true FI905275A0 (fi) 1990-10-25
FI93964B FI93964B (fi) 1995-03-15
FI93964C FI93964C (fi) 1995-06-26

Family

ID=8111114

Family Applications (1)

Application Number Title Priority Date Filing Date
FI905275A FI93964C (fi) 1988-04-26 1990-10-25 Menetelmä farmakologisesti aktiivisten aprotiniinianalogien valmistamiseksi

Country Status (14)

Country Link
US (1) US5373090A (fi)
EP (1) EP0339942B1 (fi)
JP (1) JP2810743B2 (fi)
AT (1) ATE103295T1 (fi)
AU (1) AU619553B2 (fi)
DE (1) DE68914022T2 (fi)
DK (1) DK225488D0 (fi)
ES (1) ES2061983T3 (fi)
FI (1) FI93964C (fi)
IE (1) IE64230B1 (fi)
NO (1) NO302950B1 (fi)
NZ (1) NZ228896A (fi)
WO (1) WO1989010374A1 (fi)
ZA (1) ZA893075B (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
JP4146512B2 (ja) 1991-03-01 2008-09-10 ダイアックス コープ． 小型タンパク質
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
US5807980A (en) * 1992-07-13 1998-09-15 Corvas International, Inc. Bovine pancreatic trypsin inhibitor derived inhibitors of factor VIIa-tissue factor complex
WO1994001461A1 (en) * 1992-07-13 1994-01-20 Corvas International, Inc. BOVINE PANCREATIC TRYPSIN INHIBITOR DERIVED INHIBITORS OF FACTOR Xa
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2375561T3 (es) 1994-01-11 2012-03-02 Dyax Corporation Inhibidores de la plasmina humana derivados de dominios kunitz y �?cidos nucleicos que codifican los mismos.
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
ES2559927T3 (es) 2002-06-07 2016-02-16 Dyax Corp. Prevención y reducción de pérdida de sangre y respuesta inflamatoria
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
JP2005537006A (ja) 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
PT1587907E (pt) * 2003-01-07 2011-04-08 Dyax Corp Biblioteca de domínios de kunitz
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
CA2536873C (en) * 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
AU2005318464B2 (en) 2004-12-23 2012-02-23 Csl Behring Gmbh Prevention of thrombus formation and/or stabilization
CA2696208A1 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
SI2521568T1 (sl) 2010-01-06 2019-01-31 Dyax Corp. Proteini, ki vežejo plazemski kalikrein
CN103635489B (zh) 2011-01-06 2016-04-13 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

Also Published As

Publication number Publication date
AU3560389A (en) 1989-11-24
NO302950B1 (no) 1998-05-11
IE891334L (en) 1989-10-26
ATE103295T1 (de) 1994-04-15
IE64230B1 (en) 1995-07-26
NO904622L (no) 1990-12-18
WO1989010374A1 (en) 1989-11-02
DE68914022T2 (de) 1994-07-07
US5373090A (en) 1994-12-13
EP0339942A2 (en) 1989-11-02
EP0339942B1 (en) 1994-03-23
JPH03504009A (ja) 1991-09-05
ES2061983T3 (es) 1994-12-16
FI93964C (fi) 1995-06-26
FI93964B (fi) 1995-03-15
JP2810743B2 (ja) 1998-10-15
AU619553B2 (en) 1992-01-30
EP0339942A3 (en) 1990-05-30
NO904622D0 (no) 1990-10-25
NZ228896A (en) 1991-08-27
DK225488D0 (da) 1988-04-26
ZA893075B (en) 1989-12-27
DE68914022D1 (de) 1994-04-28

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Legal Events

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MM Patent lapsed

Owner name: NOVO NORDISK A/S