ATE103295T1 - Aprotinin-analoge und verfahren zu ihrer herstellung. - Google Patents

Aprotinin-analoge und verfahren zu ihrer herstellung.

Info

Publication number
ATE103295T1
ATE103295T1 AT89304122T AT89304122T ATE103295T1 AT E103295 T1 ATE103295 T1 AT E103295T1 AT 89304122 T AT89304122 T AT 89304122T AT 89304122 T AT89304122 T AT 89304122T AT E103295 T1 ATE103295 T1 AT E103295T1
Authority
AT
Austria
Prior art keywords
processes
production
aprotinin analogues
analogues
aprotinin
Prior art date
Application number
AT89304122T
Other languages
English (en)
Inventor
Kjeld Norris
Lars Christian Petersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE103295T1 publication Critical patent/ATE103295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT89304122T 1988-04-26 1989-04-25 Aprotinin-analoge und verfahren zu ihrer herstellung. ATE103295T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK225488A DK225488D0 (da) 1988-04-26 1988-04-26 Polypeptid
EP89304122A EP0339942B1 (de) 1988-04-26 1989-04-25 Aprotinin-Analoge und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE103295T1 true ATE103295T1 (de) 1994-04-15

Family

ID=8111114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89304122T ATE103295T1 (de) 1988-04-26 1989-04-25 Aprotinin-analoge und verfahren zu ihrer herstellung.

Country Status (14)

Country Link
US (1) US5373090A (de)
EP (1) EP0339942B1 (de)
JP (1) JP2810743B2 (de)
AT (1) ATE103295T1 (de)
AU (1) AU619553B2 (de)
DE (1) DE68914022T2 (de)
DK (1) DK225488D0 (de)
ES (1) ES2061983T3 (de)
FI (1) FI93964C (de)
IE (1) IE64230B1 (de)
NO (1) NO302950B1 (de)
NZ (1) NZ228896A (de)
WO (1) WO1989010374A1 (de)
ZA (1) ZA893075B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP0575485A1 (de) 1991-03-01 1993-12-29 Dyax Corp. Verfahren zur entwicklung bindender miniproteine
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
JPH07509229A (ja) * 1992-07-13 1995-10-12 コルバス・インターナショナル、インコーポレイテッド ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子
CA2145517A1 (en) * 1992-09-25 1994-04-14 Ignace Lasters Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia - tissue factor complex
CA2180954C (en) 1994-01-11 2007-03-20 William Markland Inhibitors of human plasmin derived from the kunitz domains
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
DE19629982A1 (de) * 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
WO2003103475A2 (en) 2002-06-07 2003-12-18 Dyax Corp. Prevention and reduction of blood loss
SI2386310T1 (sl) 2002-08-28 2019-03-29 Dyax Corp. Metode za ohranjanje organov in tkiv
US20040209243A1 (en) * 2003-01-07 2004-10-21 Andrew Nixon Kunitz domain library
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
WO2005021557A2 (en) * 2003-08-29 2005-03-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
CN101102819A (zh) 2004-12-23 2008-01-09 Csl百灵有限公司 血栓的形成和/或稳定化的预防
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
HUE039605T2 (hu) 2010-01-06 2019-01-28 Dyax Corp Plazma kallikreint kötõ proteinek
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
WO2015148790A1 (en) 2014-03-27 2015-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
NZ744233A (en) 2015-12-11 2023-11-24 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology

Also Published As

Publication number Publication date
US5373090A (en) 1994-12-13
DE68914022T2 (de) 1994-07-07
IE64230B1 (en) 1995-07-26
JPH03504009A (ja) 1991-09-05
AU619553B2 (en) 1992-01-30
DE68914022D1 (de) 1994-04-28
NZ228896A (en) 1991-08-27
EP0339942B1 (de) 1994-03-23
FI905275A0 (fi) 1990-10-25
JP2810743B2 (ja) 1998-10-15
EP0339942A3 (en) 1990-05-30
ZA893075B (en) 1989-12-27
NO904622D0 (no) 1990-10-25
WO1989010374A1 (en) 1989-11-02
DK225488D0 (da) 1988-04-26
NO904622L (no) 1990-12-18
FI93964C (fi) 1995-06-26
NO302950B1 (no) 1998-05-11
IE891334L (en) 1989-10-26
AU3560389A (en) 1989-11-24
FI93964B (fi) 1995-03-15
ES2061983T3 (es) 1994-12-16
EP0339942A2 (de) 1989-11-02

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Legal Events

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REN Ceased due to non-payment of the annual fee