BR6915369D0
(pt)
*
|
1969-02-27 |
1973-03-13 |
Bayer Ag |
Emprego de inibidores biologicos de proteases para conservacao de orgaos tecidos e alimentos
|
US3691016A
(en)
*
|
1970-04-17 |
1972-09-12 |
Monsanto Co |
Process for the preparation of insoluble enzymes
|
US3940475A
(en)
|
1970-06-11 |
1976-02-24 |
Biological Developments, Inc. |
Radioimmune method of assaying quantitatively for a hapten
|
CA1023287A
(en)
*
|
1972-12-08 |
1977-12-27 |
Boehringer Mannheim G.M.B.H. |
Process for the preparation of carrier-bound proteins
|
US4179337A
(en)
*
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
DE2619246A1
(de)
*
|
1976-04-30 |
1977-11-10 |
Bayer Ag |
Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
US4195128A
(en)
*
|
1976-05-03 |
1980-03-25 |
Bayer Aktiengesellschaft |
Polymeric carrier bound ligands
|
DE2654124A1
(de)
*
|
1976-11-29 |
1978-06-01 |
Bayer Ag |
Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel
|
US4330440A
(en)
*
|
1977-02-08 |
1982-05-18 |
Development Finance Corporation Of New Zealand |
Activated matrix and method of activation
|
CA1093991A
(en)
*
|
1977-02-17 |
1981-01-20 |
Hideo Hirohara |
Enzyme immobilization with pullulan gel
|
US4229537A
(en)
*
|
1978-02-09 |
1980-10-21 |
New York University |
Preparation of trichloro-s-triazine activated supports for coupling ligands
|
US4289747A
(en)
|
1978-12-26 |
1981-09-15 |
E-Y Laboratories, Inc. |
Immunological determination using lectin
|
AT359653B
(de)
*
|
1979-02-15 |
1980-11-25 |
Immuno Ag |
Verfahren zur herstellung eines gewebekleb- stoffes
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
AU560584B2
(en)
|
1983-07-28 |
1987-04-09 |
Bayer Aktiengesellschaft |
Homologues of aprotinin
|
US4657893A
(en)
*
|
1984-05-09 |
1987-04-14 |
Syntex (U.S.A.) Inc. |
4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
|
US4845242A
(en)
*
|
1987-04-28 |
1989-07-04 |
Georgia Tech Research Corporation |
Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
|
US4609725A
(en)
*
|
1984-10-09 |
1986-09-02 |
Merck & Co., Inc. |
Cardiac atrial peptides
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
US5444156A
(en)
*
|
1985-07-12 |
1995-08-22 |
Temple University-Of The Commonwealth System Of Higher Education |
Monoclonal antibodies to human plasma prekallikrein
|
CA1312564C
(en)
|
1985-07-12 |
1993-01-12 |
Robert W. Colman |
Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same
|
JPH0623113B2
(ja)
|
1986-01-31 |
1994-03-30 |
浩 前田 |
癌性胸・腹水貯留抑制剤
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
EP0296171A4
(en)
*
|
1986-03-03 |
1989-11-07 |
Brigham & Womens Hospital |
METHOD FOR EVALUATING NEPHROTOXICITY.
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
EP0255011A3
(en)
|
1986-07-29 |
1988-11-23 |
Miles Inc. |
Human inter-alpha-trypsin inhibitor gene
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
US4881175A
(en)
*
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
ATE169673T1
(de)
|
1986-11-17 |
1998-08-15 |
Scios Inc |
Rekombiniertes alzheimer amyloid-protein
|
EP0285123A3
(en)
|
1987-04-03 |
1989-02-01 |
Stabra AG |
A method for complete mutagenesis of nucleic acids
|
US4966852A
(en)
*
|
1987-07-23 |
1990-10-30 |
Monsanto Company |
DNA clone of human tissue factor inhibitor
|
US5106833A
(en)
*
|
1987-07-23 |
1992-04-21 |
Washington University |
Coagulation inhibitors
|
IL87172A
(en)
|
1987-07-23 |
1994-12-29 |
Univ Washington |
A method of inhibiting the isolation of a purer tissue factor
|
GB2208511A
(en)
*
|
1987-08-07 |
1989-04-05 |
Bayer Ag |
Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
|
DK225488D0
(da)
*
|
1988-04-26 |
1988-04-26 |
Novo Industri As |
Polypeptid
|
ES2035317T5
(es)
|
1987-11-09 |
1998-03-16 |
Becton Dickinson Co |
Metodo para analizar celulas hematopoyeticas en una muestra.
|
IL87171A
(en)
|
1987-11-23 |
1995-08-31 |
Monsanto Co |
ANDC of human tissue factor inhibitor
|
US7078383B2
(en)
|
1988-09-02 |
2006-07-18 |
Dyax Corp. |
ITI-D1 Kunitz domain mutants as HNE inhibitors
|
EP0768377A1
(en)
|
1988-09-02 |
1997-04-16 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
US5663143A
(en)
|
1988-09-02 |
1997-09-02 |
Dyax Corp. |
Engineered human-derived kunitz domains that inhibit human neutrophil elastase
|
US5045452A
(en)
*
|
1988-09-02 |
1991-09-03 |
Brigham And Women's Hospital |
Method for evaluating nephrotoxicity
|
US5223409A
(en)
*
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
US5372933A
(en)
*
|
1988-10-03 |
1994-12-13 |
The Scripps Research Institute |
Polypeptides that mimic receptor-induced binding sites, and methods of using same
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
EP0401508B1
(de)
*
|
1989-05-13 |
1994-11-23 |
Bayer Ag |
Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
|
US5030002A
(en)
|
1989-08-11 |
1991-07-09 |
Becton, Dickinson And Company |
Method and apparatus for sorting particles with a moving catcher tube
|
US5378614A
(en)
*
|
1989-08-18 |
1995-01-03 |
Novo Nordisk A/S |
Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
|
DK408089D0
(da)
*
|
1989-08-18 |
1989-08-18 |
Novo Nordisk As |
Proteiner
|
US5278285A
(en)
*
|
1990-02-01 |
1994-01-11 |
Bayer Aktiengesellschaft |
Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
JPH06508511A
(ja)
|
1990-07-10 |
1994-09-29 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的な結合ペアーの構成員の製造方法
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
IE76732B1
(en)
|
1990-08-07 |
1997-11-05 |
Becton Dickinson Co |
One step test for absolute counts
|
US5583107A
(en)
*
|
1990-09-04 |
1996-12-10 |
Cor Therapeutics, Inc. |
Agents affecting thrombosis and hemostasis
|
US5278144A
(en)
*
|
1990-09-04 |
1994-01-11 |
Cor Therapeutics, Inc. |
Antithrombosis agents
|
IL99585A0
(en)
|
1990-10-01 |
1992-08-18 |
Novo Nordisk As |
Aprotinin analogues,their production and pharmaceutical compositions containing them
|
EP0486001A1
(en)
|
1990-11-13 |
1992-05-20 |
Mochida Pharmaceutical Co., Ltd. |
Recombinant urinary trypsin inhibitor fragments and drug composition
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
US5304122A
(en)
|
1991-02-14 |
1994-04-19 |
Medtronic, Inc. |
Method for providing a restenosis model in porcine coronary arteries
|
US5370901A
(en)
|
1991-02-15 |
1994-12-06 |
Bracco International B.V. |
Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
|
US20030223977A1
(en)
|
1991-03-01 |
2003-12-04 |
Ley Arthur Charles |
Kunitz domain mutants as cathepsin G inhibitors
|
DK1279731T3
(da)
|
1991-03-01 |
2007-09-24 |
Dyax Corp |
Fremgangsmåde til udvikling af bindende miniproteiner
|
DK1471142T3
(da)
|
1991-04-10 |
2009-03-09 |
Scripps Research Inst |
Heterodimere receptor-biblioteker under anvendelse af fagemider
|
US5166133A
(en)
*
|
1991-04-17 |
1992-11-24 |
Cetus Corporation |
Method for inhibing adhesion of white blood cells to endothelial cells
|
LU91067I2
(fr)
|
1991-06-14 |
2004-04-02 |
Genentech Inc |
Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
WO1993009233A2
(en)
|
1991-10-31 |
1993-05-13 |
The Salk Institute Biotechnology/Industrial Associates Inc. |
Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
|
IL104327A0
(en)
*
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
IL104314A0
(en)
*
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
IL104324A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
IL104326A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
IL104325A
(en)
|
1992-01-07 |
2000-10-31 |
Novo Nordisk As |
Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
|
EP0552108B1
(en)
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Energy transfer phase-modulation fluoro-immunoassay
|
US5212091A
(en)
*
|
1992-03-02 |
1993-05-18 |
Monsanto Company |
Method of producing tissue factor pathway inhibitor
|
US6063764A
(en)
*
|
1992-06-01 |
2000-05-16 |
Washington University & Chiron Corp. |
Method for using lipoprotein associated coagulation inhibitor to treat sepsis
|
SE9201984D0
(sv)
|
1992-06-29 |
1992-06-29 |
Pharmacia Biosensor Ab |
Improvement in optical assays
|
US5747449A
(en)
*
|
1992-07-13 |
1998-05-05 |
Corvas International, Inc. |
Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA
|
US5436153A
(en)
*
|
1992-12-02 |
1995-07-25 |
Sprecher; Cindy A. |
Human amyloid protein precursor homolog and Kunitz-type inhibitor
|
EP0740702A1
(en)
*
|
1992-12-02 |
1996-11-06 |
Zymogenetics, Inc. |
Novel human amyloid protein precursor homologue and kunitz-type inhibitors
|
US5426224A
(en)
*
|
1993-03-18 |
1995-06-20 |
The University Of North Carolina At Chapel Hill |
Mammalian DNA topoisomerase II inhibitor and method
|
WO1995007986A1
(en)
|
1993-09-14 |
1995-03-23 |
Genentech, Inc. |
Pharmaceutical compositions containing ecotin and homologs thereof
|
US5455338A
(en)
|
1993-11-05 |
1995-10-03 |
Zymogenetics, Inc. |
DNA encoding novel human kunitz-type inhibitors and methods relating thereto
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
US5446090A
(en)
*
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
US5759548A
(en)
*
|
1993-11-30 |
1998-06-02 |
Lxr Biotechnology Inc. |
Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
ES2229236T3
(es)
|
1994-01-11 |
2005-04-16 |
Dyax Corporation |
Inhibidores de la plasmina humana derivados de los dominios de kunitz.
|
ATE275583T1
(de)
|
1994-01-11 |
2004-09-15 |
Dyax Corp |
KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
US5795954A
(en)
*
|
1994-03-04 |
1998-08-18 |
Genentech, Inc. |
Factor VIIa inhibitors from Kunitz domain proteins
|
EP0763055B1
(en)
*
|
1994-06-02 |
1999-11-03 |
Merrell Pharmaceuticals Inc. |
Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
|
CA2196296C
(en)
*
|
1994-08-05 |
2004-04-06 |
Michael A. Innis |
Production of tissue factor pathway inhibitor
|
US5589359A
(en)
*
|
1994-08-05 |
1996-12-31 |
Chiron Corporation |
Chimeric proteins
|
US5648331A
(en)
*
|
1994-08-26 |
1997-07-15 |
G.D. Searle & Co. |
Method of inhibiting tissue ischemia and reperfusion injury
|
EP0788546B9
(en)
*
|
1994-10-18 |
2007-06-13 |
Dendreon Corporation |
Nematode-extracted serine protease inhibitors and anticoagulant proteins
|
US6159938A
(en)
|
1994-11-21 |
2000-12-12 |
Cortech, Inc. |
Serine protease inhibitors comprising α-keto heterocycles
|
EP1609477B1
(en)
*
|
1994-12-12 |
2011-11-09 |
Omeros Corporation |
Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
|
US5914316A
(en)
*
|
1994-12-16 |
1999-06-22 |
Washington University |
Method of inhibiting intimal hyperplasia
|
US5932462A
(en)
*
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
WO1996028427A1
(en)
|
1995-03-10 |
1996-09-19 |
Berlex Laboratories, Inc. |
Benzamidine derivatives their preparation and their use as anti-coagulants
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5804376A
(en)
*
|
1995-05-02 |
1998-09-08 |
Incyte Pharmaceuticals, Inc. |
Pancreas-derived serpin
|
CA2220497A1
(en)
|
1995-05-08 |
1996-11-14 |
Scios, Inc. |
Kunitz type protease inhibitors
|
ZA963619B
(en)
|
1995-05-08 |
1996-11-22 |
Scios Inc |
Protease inhibitor peptides
|
US5786328A
(en)
*
|
1995-06-05 |
1998-07-28 |
Genentech, Inc. |
Use of kunitz type plasma kallikrein inhibitors
|
US5780265A
(en)
*
|
1995-06-05 |
1998-07-14 |
Genentech, Inc. |
Kunitz type plasma kallikrein inhibitors
|
US6242414B1
(en)
|
1995-06-07 |
2001-06-05 |
Chiron Corporation |
Regulation of cytokine synthesis and release
|
US6126933A
(en)
|
1995-06-27 |
2000-10-03 |
Genetics Institute |
Methods of treating inflammatory bowel diseases by administering IL-11
|
US5672662A
(en)
*
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
JPH0959838A
(ja)
|
1995-08-24 |
1997-03-04 |
Kuraray Co Ltd |
紡績糸
|
JPH11512439A
(ja)
*
|
1995-09-14 |
1999-10-26 |
エルエックスアール バイオテクノロジー インコーポレイテッド |
リン脂質の混合物を含む抗アポトーシス活性を有する組成物
|
WO1997010847A1
(en)
*
|
1995-09-21 |
1997-03-27 |
University Of Utah Research Foundation |
Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
|
US5736364A
(en)
*
|
1995-12-04 |
1998-04-07 |
Genentech, Inc. |
Factor viia inhibitors
|
BR9509985A
(pt)
|
1995-12-12 |
1998-11-03 |
Omeros Med Sys Inc |
Solução para irrigação e método para inibição de dor inflamação e esparmo
|
HU226419B1
(en)
|
1996-03-11 |
2008-12-29 |
Aerovance |
Human bikunin
|
US6013763A
(en)
*
|
1996-06-04 |
2000-01-11 |
Genentech, Inc. |
Peptide variants of protein A
|
US5869637A
(en)
*
|
1996-07-22 |
1999-02-09 |
Incyte Pharmaceuticals, Inc. |
Human Kallikrein
|
DE19632772A1
(de)
|
1996-08-14 |
1998-02-19 |
Basf Ag |
Neue Benzamidine
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
CA2273194C
(en)
|
1996-12-03 |
2011-02-01 |
Abgenix, Inc. |
Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
|
WO1998031700A1
(en)
|
1997-01-21 |
1998-07-23 |
The General Hospital Corporation |
Selection of proteins using rna-protein fusions
|
US5840871A
(en)
*
|
1997-01-29 |
1998-11-24 |
Incyte Pharmaceuticals, Inc. |
Prostate-associated kallikrein
|
CA2279345A1
(en)
|
1997-01-31 |
1998-08-06 |
Human Genome Sciences, Inc. |
Tissue factor pathway inhibitor-3
|
US5962300A
(en)
*
|
1997-03-26 |
1999-10-05 |
Incyte Pharmaceuticals, Inc. |
Human kallikrein
|
DE69833755T2
(de)
|
1997-05-21 |
2006-12-28 |
Biovation Ltd. |
Verfahren zur herstellung von nicht-immunogenen proteinen
|
US5990237A
(en)
*
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
JP3786832B2
(ja)
|
1998-01-07 |
2006-06-14 |
デビオ ルシェルシュ ファルマシュティーク ソシエテ アノニム |
分解性のヘテロ二官能性ポリ(エチレングリコール)アクリレート及びそれから誘導されるゲル及び複合体
|
JP4078032B2
(ja)
|
1998-03-12 |
2008-04-23 |
ネクター セラピューティックス エイエル,コーポレイション |
近位の反応性基を持つポリ(エチレングリコール)誘導体
|
AU2855499A
(en)
|
1998-03-24 |
1999-10-18 |
Nof Corporation |
Oxirane derivatives and process for producing the same
|
US6017723A
(en)
*
|
1998-03-27 |
2000-01-25 |
Long Island Jewish Medical Center |
Method for isolating inhibitors of protease activity
|
CA2323638A1
(en)
|
1998-04-03 |
1999-10-14 |
Phylos, Inc. |
Addressable protein arrays
|
US6001596A
(en)
*
|
1998-05-07 |
1999-12-14 |
Incyte Pharmaceuticals, Inc. |
Growth-associated protease inhibitor heavy chain precursor
|
US6087473A
(en)
*
|
1999-05-26 |
2000-07-11 |
Zymogenetics, Inc. |
Kunitz domain polypeptide and materials and methods for making it
|
AU4229599A
(en)
|
1998-06-03 |
1999-12-20 |
Scios Inc. |
Protease inhibitor peptides
|
US6034053A
(en)
|
1998-07-13 |
2000-03-07 |
Wayne Hughes Institute |
EGF-isoflavone conjugates for the prevention of restenosis
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
ATE498409T1
(de)
|
1998-08-06 |
2011-03-15 |
Mountain View Pharmaceuticals |
Peg-uricase konjugate und verwendung davon
|
JP2002524076A
(ja)
|
1998-09-03 |
2002-08-06 |
ザイモジェネティクス,インコーポレイティド |
KunitzドメインポリペプチドZKUN6
|
US7067144B2
(en)
|
1998-10-20 |
2006-06-27 |
Omeros Corporation |
Compositions and methods for systemic inhibition of cartilage degradation
|
US6114382A
(en)
|
1998-11-11 |
2000-09-05 |
Moretti; Itagiba G. |
Methods for treating inflammatory bowel disease
|
JP2002531089A
(ja)
|
1998-11-30 |
2002-09-24 |
イーライ・リリー・アンド・カンパニー |
赤血球産生性化合物
|
JP2002534959A
(ja)
|
1998-12-08 |
2002-10-22 |
バイオベーション リミテッド |
免疫原性タンパク質の改変方法
|
US6610503B1
(en)
|
1999-03-17 |
2003-08-26 |
Xenogen Corporation |
Animal models for predicting sepsis mortality
|
US20030012969A1
(en)
|
1999-04-06 |
2003-01-16 |
Clark Bert Thomas |
Soluble membrane strengthened paper products
|
US6605316B1
(en)
|
1999-07-31 |
2003-08-12 |
The Regents Of The University Of California |
Structures and fabrication techniques for solid state electrochemical devices
|
US6180607B1
(en)
|
1999-08-05 |
2001-01-30 |
Christopher Davies |
Protein having proteinase inhibitor activity
|
US6984720B1
(en)
|
1999-08-24 |
2006-01-10 |
Medarex, Inc. |
Human CTLA-4 antibodies
|
JP2003513681A
(ja)
|
1999-11-12 |
2003-04-15 |
マキシゲン・ホールディングス・リミテッド |
インターフェロンガンマ・コンジュゲート
|
GB9928787D0
(en)
|
1999-12-03 |
2000-02-02 |
Medical Res Council |
Direct screening method
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
ATE424431T2
(de)
|
1999-12-22 |
2009-03-15 |
Nektar Therapeutics Al Corp |
Verfahren zur herstellung von 1- benzotriazolcarbonatestern von wasserlöslichen polymeren
|
US6544760B2
(en)
|
1999-12-22 |
2003-04-08 |
Zymogenetics, Inc. |
Kunitz domain polypeptide Zkun11
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
US20020102703A1
(en)
|
1999-12-29 |
2002-08-01 |
Sheppard Paul O. |
Kunitz domain polypeptide zkun10
|
GB9930882D0
(en)
|
1999-12-30 |
2000-02-23 |
Nps Allelix Corp |
GLP-2 formulations
|
WO2001068707A1
(en)
|
2000-03-13 |
2001-09-20 |
Eli Lilly And Company |
Human hepatocyte growth factor activator inhibitor homologue
|
CA2405557C
(en)
|
2000-04-12 |
2013-09-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
CN1331213A
(zh)
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人大蛋白10.01和编码这种多肽的多核苷酸
|
DE10034357C1
(de)
|
2000-07-14 |
2001-12-13 |
Elotherm Gmbh |
Verfahren und Vorrichtung zum Härten von Flächen an Bauteilen
|
CN1287856C
(zh)
|
2000-10-31 |
2006-12-06 |
德比奥药物股份有限公司 |
Epi-hne蛋白质干粉
|
US20030113726A1
(en)
|
2000-12-04 |
2003-06-19 |
Zenta Tsuchihashi |
Human single nucleotide polymorphisms
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
WO2002092147A2
(en)
|
2001-05-11 |
2002-11-21 |
Aradigm Corporation |
Optimization of the molecular properties and formulation of proteins delivered by inhalation
|
NZ529572A
(en)
|
2001-05-21 |
2006-02-24 |
Nektar Therapeutics |
Pulmonary administration of chemically modified insulin
|
US20040152633A1
(en)
|
2001-05-31 |
2004-08-05 |
Jorgensen Marianne Ulrich |
Kunitz-type sequences and polypeptides
|
CN100366965C
(zh)
|
2001-07-10 |
2008-02-06 |
日本电产三协株式会社 |
阀驱动设备
|
US20030096733A1
(en)
|
2001-07-10 |
2003-05-22 |
Omnio Ab |
Novel drug targets for arthritis
|
US6913900B2
(en)
*
|
2001-08-29 |
2005-07-05 |
Nippon Zoki Pharmaceutical Co., Ltd. |
Plasma prekallikrein activation and kallikrein production assay
|
ATE434040T1
(de)
|
2001-10-01 |
2009-07-15 |
Dyax Corp |
Mehrkettige eukaryontische display-vektoren und deren verwendungen
|
US20040005709A1
(en)
|
2001-10-24 |
2004-01-08 |
Hoogenboom Henricus Renerus Jacobus Mattheus |
Hybridization control of sequence variation
|
JP4653915B2
(ja)
|
2001-10-29 |
2011-03-16 |
独立行政法人科学技術振興機構 |
全身性エリテマトーデスモデル非ヒト動物
|
JP5290489B2
(ja)
|
2001-11-08 |
2013-09-18 |
アッヴィ・バイオセラピューティクス・インコーポレイテッド |
Igg抗体の安定な液体医薬製剤
|
NZ534492A
(en)
|
2002-02-07 |
2009-10-30 |
Novozymes Delta Ltd |
Albumin-fused kunitz domain peptides
|
US7153829B2
(en)
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
ATE477020T1
(de)
|
2002-06-07 |
2010-08-15 |
Dyax Corp |
Prevention und verringerung von ischemia
|
US7132100B2
(en)
|
2002-06-14 |
2006-11-07 |
Medimmune, Inc. |
Stabilized liquid anti-RSV antibody formulations
|
CN100357317C
(zh)
|
2002-07-24 |
2007-12-26 |
弗·哈夫曼-拉罗切有限公司 |
聚乙二醇化的t20多肽
|
EP1526872A1
(en)
|
2002-07-24 |
2005-05-04 |
F. Hoffmann-La Roche Ag |
Polyalkylene glycol acid additives
|
PT2386310T
(pt)
|
2002-08-28 |
2019-02-05 |
Dyax Corp |
Métodos para preservar órgãos e tecidos
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
AU2003303635B2
(en)
|
2002-12-26 |
2009-07-23 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates of interferon-beta with enhanced biological potency
|
DE602004031589D1
(de)
|
2003-01-07 |
2011-04-14 |
Dyax Corp |
Kunitz-domäne-bibliothek
|
EP2174663A1
(en)
|
2003-01-08 |
2010-04-14 |
Novartis Vaccines and Diagnostics, Inc. |
Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant
|
ATE404176T1
(de)
|
2003-01-08 |
2008-08-15 |
Novartis Vaccines & Diagnostic |
Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors
|
US6989369B2
(en)
|
2003-02-07 |
2006-01-24 |
Dyax Corp. |
Kunitz domain peptides
|
GB0303085D0
(en)
|
2003-02-11 |
2003-03-19 |
Pfizer Ltd |
Model
|
EP1660537A2
(en)
|
2003-08-14 |
2006-05-31 |
Dyax Corp. |
Endotheliase-2 ligands
|
CA2536873C
(en)
|
2003-08-29 |
2019-09-10 |
Dyax Corp. |
Poly-pegylated protease inhibitors
|
WO2005021556A2
(en)
|
2003-08-29 |
2005-03-10 |
Dyax Corp. |
Modified protease inhibitors
|
EP1674480A4
(en)
*
|
2003-09-04 |
2007-06-20 |
Riken |
ANTIBODY RECOGNIZING THE REGIONAL SECTION CONTROLLING TGF-BETA ACTIVATION
|
WO2005027753A1
(en)
|
2003-09-19 |
2005-03-31 |
St. Jude Medical, Inc. |
Apparatus and methods for tissue gathering and securing
|
US7268109B2
(en)
|
2003-10-02 |
2007-09-11 |
Elan Pharmaceuticals, Inc. |
Method for reducing pain
|
US20060228331A1
(en)
|
2003-10-10 |
2006-10-12 |
Novo Nordisk A/S |
IL-21 Derivatives and variants
|
WO2005041631A2
(en)
|
2003-10-21 |
2005-05-12 |
Dyax Corp. |
Endotheliase-1 ligands
|
EP1713929A2
(en)
*
|
2004-02-03 |
2006-10-25 |
Bayer HealthCare AG |
Diagnostics and therapeutics for diseases associated with plasma kallikrein (klkb1)
|
JP2008515774A
(ja)
|
2004-08-03 |
2008-05-15 |
ダイアックス コーポレイション |
hK1結合タンパク質
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
CA2587775A1
(en)
|
2004-11-22 |
2006-06-01 |
Dyax Corp. |
Plasmin-inhibitory therapies
|
DK1830924T3
(da)
|
2004-12-23 |
2013-05-21 |
Csl Behring Gmbh |
Forebyggelse af thrombedannelse og/eller -stabilisering
|
WO2006089005A2
(en)
|
2005-02-17 |
2006-08-24 |
Bristol-Myers Squibb Company |
Combination of selective factor viia and/or xia and plasma kallikrein inhibitors
|
WO2006117565A2
(en)
|
2005-05-04 |
2006-11-09 |
Zealand Pharma A/S |
Glucagon-like-peptide-2 (glp-2) analogues
|
US20070079096A1
(en)
|
2005-09-30 |
2007-04-05 |
Chih-Wei Chen |
Data storage unit access authorization table automatic rebuilding method and system
|
SI1981519T1
(en)
|
2005-12-29 |
2018-05-31 |
Dyax Corp. |
INHIBITION PROTEAZE
|
US7276480B1
(en)
|
2005-12-30 |
2007-10-02 |
Dyax Corp. |
Prevention and reduction of blood loss
|
JP2009529542A
(ja)
|
2006-03-10 |
2009-08-20 |
ダイアックス コーポレーション |
エカランチドに関する配合物
|
HUE039108T2
(hu)
|
2006-03-16 |
2018-12-28 |
Dyax Corp |
Készítmények és eljárások szembetegségek kezelésére
|
EP1873344A1
(de)
|
2006-06-30 |
2008-01-02 |
Sika Technology AG |
Mittels Silikon agedichtete Verklebung
|
EP2051707B1
(en)
*
|
2006-07-31 |
2013-07-17 |
Activesite Pharmaceuticals, Inc. |
Inhibitors of plasma kallikrein
|
US20080299050A1
(en)
|
2006-10-05 |
2008-12-04 |
Drugtech Corporation |
Topical therapies for oral mucositis and other conditions
|
KR100846354B1
(ko)
|
2007-03-21 |
2008-07-15 |
(주) 프로탄바이오 |
혈청 당단백질부터 분리한 폐암 진단용 마커
|
WO2009026334A2
(en)
|
2007-08-21 |
2009-02-26 |
Genzyme Corporation |
Treatment with kallikrein inhibitors
|
AU2008288772A1
(en)
|
2007-08-23 |
2009-02-26 |
Genzyme Corporation |
Treatment with kallikrein inhibitors
|
US8359965B2
(en)
|
2007-09-17 |
2013-01-29 |
Oxford J Craig |
Apparatus and method for broad spectrum radiation attenuation
|
AU2009214590A1
(en)
|
2008-02-13 |
2009-08-20 |
Dyax Corp. |
Improved methods for producing specific binding pairs
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
DE102008033095A1
(de)
|
2008-07-15 |
2010-01-28 |
Uhde Gmbh |
Vorrichtung zur Schlackeabführung aus einem Kohlevergasungsreaktor
|
AU2010203712A1
(en)
*
|
2009-01-06 |
2010-07-15 |
Dyax Corp. |
Treatment of mucositis with kallikrein inhibitors
|
CN101928346B
(zh)
|
2009-07-31 |
2013-01-16 |
华中科技大学同济医学院附属同济医院 |
一种抗人组织激肽释放酶单克隆抗体及其制备
|
JP6037841B2
(ja)
|
2010-01-06 |
2016-12-07 |
ダイアックス コーポレーション |
血漿カリクレイン結合タンパク質
|
AU2012204202A1
(en)
|
2011-01-06 |
2013-07-11 |
Dyax Corp. |
Plasma kallikrein binding proteins
|
WO2012142308A1
(en)
|
2011-04-13 |
2012-10-18 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
EP2704742B1
(en)
|
2011-05-02 |
2017-07-12 |
Millennium Pharmaceuticals, Inc. |
Formulation for anti- 4 7 antibody
|
US9216219B2
(en)
|
2012-06-12 |
2015-12-22 |
Novartis Ag |
Anti-BAFFR antibody formulation
|
SI2946206T1
(sl)
|
2013-01-20 |
2019-06-28 |
Dyax Corp. |
Ocenjevanje, testi in zdravljenje motenj, pri katerih posreduje PKA
|
ES2692408T3
(es)
|
2013-01-20 |
2018-12-03 |
Dyax Corp. |
Evaluación y tratamiento de trastornos mediados por bradiquinina
|
EP2970502A4
(en)
|
2013-03-15 |
2016-11-30 |
Dyax Corp |
ANTI-PLASMA KALLIKREIN ANTIBODY
|
KR20140119396A
(ko)
|
2013-03-29 |
2014-10-10 |
삼성전자주식회사 |
단백질 약물의 액상 제형
|
KR102424183B1
(ko)
|
2014-01-21 |
2022-07-26 |
다케다 파머수티컬 컴패니 리미티드 |
혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도
|
US10428158B2
(en)
|
2014-03-27 |
2019-10-01 |
Dyax Corp. |
Compositions and methods for treatment of diabetic macular edema
|
IL305207A
(en)
|
2015-03-30 |
2023-10-01 |
Takeda Pharmaceuticals Co |
Plasma kallikrein inhibitors and their uses to prevent the outbreak of hereditary angioedema
|
CN108602893A
(zh)
|
2015-12-11 |
2018-09-28 |
戴埃克斯有限公司 |
血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
|
JP2022525164A
(ja)
|
2019-03-14 |
2022-05-11 |
武田薬品工業株式会社 |
遺伝性血管性浮腫の発作を処置するための血漿カリクレイン阻害剤およびその使用
|