|
BR6915369D0
(pt)
*
|
1969-02-27 |
1973-03-13 |
Bayer Ag |
Emprego de inibidores biologicos de proteases para conservacao de orgaos tecidos e alimentos
|
|
US3691016A
(en)
*
|
1970-04-17 |
1972-09-12 |
Monsanto Co |
Process for the preparation of insoluble enzymes
|
|
US3940475A
(en)
|
1970-06-11 |
1976-02-24 |
Biological Developments, Inc. |
Radioimmune method of assaying quantitatively for a hapten
|
|
CA1023287A
(en)
*
|
1972-12-08 |
1977-12-27 |
Boehringer Mannheim G.M.B.H. |
Process for the preparation of carrier-bound proteins
|
|
US4179337A
(en)
*
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
DE2619246A1
(de)
*
|
1976-04-30 |
1977-11-10 |
Bayer Ag |
Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
|
US4195128A
(en)
*
|
1976-05-03 |
1980-03-25 |
Bayer Aktiengesellschaft |
Polymeric carrier bound ligands
|
|
DE2654124A1
(de)
*
|
1976-11-29 |
1978-06-01 |
Bayer Ag |
Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel
|
|
US4330440A
(en)
*
|
1977-02-08 |
1982-05-18 |
Development Finance Corporation Of New Zealand |
Activated matrix and method of activation
|
|
CA1093991A
(en)
*
|
1977-02-17 |
1981-01-20 |
Hideo Hirohara |
Enzyme immobilization with pullulan gel
|
|
US4229537A
(en)
*
|
1978-02-09 |
1980-10-21 |
New York University |
Preparation of trichloro-s-triazine activated supports for coupling ligands
|
|
US4289747A
(en)
|
1978-12-26 |
1981-09-15 |
E-Y Laboratories, Inc. |
Immunological determination using lectin
|
|
AT359653B
(de)
*
|
1979-02-15 |
1980-11-25 |
Immuno Ag |
Verfahren zur herstellung eines gewebekleb- stoffes
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
*
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
AU560584B2
(en)
*
|
1983-07-28 |
1987-04-09 |
Bayer Aktiengesellschaft |
Homologues of aprotinin
|
|
US4657893A
(en)
*
|
1984-05-09 |
1987-04-14 |
Syntex (U.S.A.) Inc. |
4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
|
|
US4845242A
(en)
*
|
1987-04-28 |
1989-07-04 |
Georgia Tech Research Corporation |
Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
|
|
US4609725A
(en)
*
|
1984-10-09 |
1986-09-02 |
Merck & Co., Inc. |
Cardiac atrial peptides
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US5444156A
(en)
*
|
1985-07-12 |
1995-08-22 |
Temple University-Of The Commonwealth System Of Higher Education |
Monoclonal antibodies to human plasma prekallikrein
|
|
CA1312564C
(en)
|
1985-07-12 |
1993-01-12 |
Robert W. Colman |
Monoclonal antibodies to human plasma prekallikrein and methods of preparing and using same
|
|
JPH0623113B2
(ja)
|
1986-01-31 |
1994-03-30 |
浩 前田 |
癌性胸・腹水貯留抑制剤
|
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
|
WO1987005396A1
(en)
*
|
1986-03-03 |
1987-09-11 |
Brigham And Women's Hospital |
A method for evaluating nephrotoxicity
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
EP0255011A3
(en)
|
1986-07-29 |
1988-11-23 |
Miles Inc. |
Human inter-alpha-trypsin inhibitor gene
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US5260203A
(en)
*
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
JPH0779702B2
(ja)
|
1986-11-17 |
1995-08-30 |
サイオス ノバ インコーポレイテッド |
組換えアルツハイマーアミロイドタンパク
|
|
EP0285123A3
(en)
|
1987-04-03 |
1989-02-01 |
Stabra AG |
A method for complete mutagenesis of nucleic acids
|
|
US4966852A
(en)
*
|
1987-07-23 |
1990-10-30 |
Monsanto Company |
DNA clone of human tissue factor inhibitor
|
|
US5106833A
(en)
*
|
1987-07-23 |
1992-04-21 |
Washington University |
Coagulation inhibitors
|
|
IL87172A
(en)
|
1987-07-23 |
1994-12-29 |
Univ Washington |
A method of inhibiting the isolation of a purer tissue factor
|
|
GB2208511A
(en)
|
1987-08-07 |
1989-04-05 |
Bayer Ag |
Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
|
|
DK225488D0
(da)
|
1988-04-26 |
1988-04-26 |
Novo Industri As |
Polypeptid
|
|
ES2035317T5
(es)
|
1987-11-09 |
1998-03-16 |
Becton Dickinson Co |
Metodo para analizar celulas hematopoyeticas en una muestra.
|
|
IL87171A
(en)
|
1987-11-23 |
1995-08-31 |
Monsanto Co |
ANDC of human tissue factor inhibitor
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5663143A
(en)
*
|
1988-09-02 |
1997-09-02 |
Dyax Corp. |
Engineered human-derived kunitz domains that inhibit human neutrophil elastase
|
|
US5045452A
(en)
*
|
1988-09-02 |
1991-09-03 |
Brigham And Women's Hospital |
Method for evaluating nephrotoxicity
|
|
DE68927933T2
(de)
|
1988-09-02 |
1997-08-14 |
Dyax Corp |
Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
|
|
US7078383B2
(en)
|
1988-09-02 |
2006-07-18 |
Dyax Corp. |
ITI-D1 Kunitz domain mutants as HNE inhibitors
|
|
US5372933A
(en)
*
|
1988-10-03 |
1994-12-13 |
The Scripps Research Institute |
Polypeptides that mimic receptor-induced binding sites, and methods of using same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
ES2066033T3
(es)
|
1989-05-13 |
1995-03-01 |
Bayer Ag |
Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
|
|
US5030002A
(en)
|
1989-08-11 |
1991-07-09 |
Becton, Dickinson And Company |
Method and apparatus for sorting particles with a moving catcher tube
|
|
DK408089D0
(da)
*
|
1989-08-18 |
1989-08-18 |
Novo Nordisk As |
Proteiner
|
|
US5378614A
(en)
*
|
1989-08-18 |
1995-01-03 |
Novo Nordisk A/S |
Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
|
|
US5278285A
(en)
*
|
1990-02-01 |
1994-01-11 |
Bayer Aktiengesellschaft |
Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
JPH06508511A
(ja)
|
1990-07-10 |
1994-09-29 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的な結合ペアーの構成員の製造方法
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
IE76732B1
(en)
|
1990-08-07 |
1997-11-05 |
Becton Dickinson Co |
One step test for absolute counts
|
|
US5278144A
(en)
*
|
1990-09-04 |
1994-01-11 |
Cor Therapeutics, Inc. |
Antithrombosis agents
|
|
US5583107A
(en)
*
|
1990-09-04 |
1996-12-10 |
Cor Therapeutics, Inc. |
Agents affecting thrombosis and hemostasis
|
|
IL99585A0
(en)
|
1990-10-01 |
1992-08-18 |
Novo Nordisk As |
Aprotinin analogues,their production and pharmaceutical compositions containing them
|
|
US5409895A
(en)
*
|
1990-11-13 |
1995-04-25 |
Mochida Pharmaceutical Co., Ltd. |
Protease inhibitory polypeptides derived from urinary trypsin inhibitor and compositions thereof
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5304122A
(en)
|
1991-02-14 |
1994-04-19 |
Medtronic, Inc. |
Method for providing a restenosis model in porcine coronary arteries
|
|
US5370901A
(en)
|
1991-02-15 |
1994-12-06 |
Bracco International B.V. |
Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
|
|
EP0575485A1
(en)
|
1991-03-01 |
1993-12-29 |
Dyax Corp. |
Process for the development of binding mini-proteins
|
|
US20030223977A1
(en)
|
1991-03-01 |
2003-12-04 |
Ley Arthur Charles |
Kunitz domain mutants as cathepsin G inhibitors
|
|
JP3672306B2
(ja)
|
1991-04-10 |
2005-07-20 |
ザ スクリップス リサーチ インスティテュート |
ファージミドを使用するヘテロ二量体受容体ライブラリー
|
|
US5166133A
(en)
*
|
1991-04-17 |
1992-11-24 |
Cetus Corporation |
Method for inhibing adhesion of white blood cells to endothelial cells
|
|
AU675916B2
(en)
|
1991-06-14 |
1997-02-27 |
Genentech Inc. |
Method for making humanized antibodies
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
AU3061092A
(en)
|
1991-10-31 |
1993-06-07 |
Salk Institute Biotechnology/Industrial Associates, Inc., The |
Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
|
|
IL104327A0
(en)
*
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
IL104325A
(en)
|
1992-01-07 |
2000-10-31 |
Novo Nordisk As |
Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
|
|
IL104324A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
IL104326A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
IL104314A0
(en)
*
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
|
CA2087413A1
(en)
|
1992-01-17 |
1993-07-18 |
Joseph R. Lakowicz |
Fluorescent energy transfer immunoassay
|
|
US5212091A
(en)
*
|
1992-03-02 |
1993-05-18 |
Monsanto Company |
Method of producing tissue factor pathway inhibitor
|
|
US6063764A
(en)
*
|
1992-06-01 |
2000-05-16 |
Washington University & Chiron Corp. |
Method for using lipoprotein associated coagulation inhibitor to treat sepsis
|
|
SE9201984D0
(sv)
|
1992-06-29 |
1992-06-29 |
Pharmacia Biosensor Ab |
Improvement in optical assays
|
|
JPH07509229A
(ja)
*
|
1992-07-13 |
1995-10-12 |
コルバス・インターナショナル、インコーポレイテッド |
ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子
|
|
AU5684594A
(en)
*
|
1992-12-02 |
1994-06-22 |
Novo Nordisk A/S |
Novel human amyloid protein precursor homologue and kunitz-type inhibitors
|
|
US5436153A
(en)
*
|
1992-12-02 |
1995-07-25 |
Sprecher; Cindy A. |
Human amyloid protein precursor homolog and Kunitz-type inhibitor
|
|
US5426224A
(en)
*
|
1993-03-18 |
1995-06-20 |
The University Of North Carolina At Chapel Hill |
Mammalian DNA topoisomerase II inhibitor and method
|
|
WO1995007986A1
(en)
*
|
1993-09-14 |
1995-03-23 |
Genentech, Inc. |
Pharmaceutical compositions containing ecotin and homologs thereof
|
|
US5455338A
(en)
*
|
1993-11-05 |
1995-10-03 |
Zymogenetics, Inc. |
DNA encoding novel human kunitz-type inhibitors and methods relating thereto
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5446090A
(en)
*
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5759548A
(en)
*
|
1993-11-30 |
1998-06-02 |
Lxr Biotechnology Inc. |
Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
|
|
US5827690A
(en)
*
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
JP3805785B2
(ja)
|
1994-01-11 |
2006-08-09 |
ダイアックス コープ． |
カリクレイン阻害クニッツドメイン蛋白質およびその相同体
|
|
CA2180954C
(en)
|
1994-01-11 |
2007-03-20 |
William Markland |
Inhibitors of human plasmin derived from the kunitz domains
|
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
|
US5795954A
(en)
*
|
1994-03-04 |
1998-08-18 |
Genentech, Inc. |
Factor VIIa inhibitors from Kunitz domain proteins
|
|
ATE186305T1
(de)
*
|
1994-06-02 |
1999-11-15 |
Merrell Pharma Inc |
Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung
|
|
EP0774001B1
(en)
*
|
1994-08-05 |
2002-10-16 |
Chiron Corporation |
Production of tissue factor pathway inhibitor
|
|
US5589359A
(en)
|
1994-08-05 |
1996-12-31 |
Chiron Corporation |
Chimeric proteins
|
|
US5648331A
(en)
*
|
1994-08-26 |
1997-07-15 |
G.D. Searle & Co. |
Method of inhibiting tissue ischemia and reperfusion injury
|
|
WO1996012021A2
(en)
*
|
1994-10-18 |
1996-04-25 |
Corvas International, Inc. |
Nematode-extracted serine protease inhibitors and anticoagulant proteins
|
|
US6159938A
(en)
|
1994-11-21 |
2000-12-12 |
Cortech, Inc. |
Serine protease inhibitors comprising α-keto heterocycles
|
|
JPH10510540A
(ja)
|
1994-12-12 |
1998-10-13 |
オメロス メディカル システムズ，インコーポレーテッド |
灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
|
|
EP1609477B1
(en)
*
|
1994-12-12 |
2011-11-09 |
Omeros Corporation |
Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure
|
|
US5914316A
(en)
*
|
1994-12-16 |
1999-06-22 |
Washington University |
Method of inhibiting intimal hyperplasia
|
|
US5932462A
(en)
*
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
CA2214685C
(en)
|
1995-03-10 |
2008-05-20 |
Berlex Laboratories, Inc. |
Benzamidine derivatives their preparation and their use as anti-coagulants
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5804376A
(en)
*
|
1995-05-02 |
1998-09-08 |
Incyte Pharmaceuticals, Inc. |
Pancreas-derived serpin
|
|
JPH11504938A
(ja)
|
1995-05-08 |
1999-05-11 |
サイオス インク． |
クニッツ型プロテアーゼ阻害因子
|
|
ZA963619B
(en)
*
|
1995-05-08 |
1996-11-22 |
Scios Inc |
Protease inhibitor peptides
|
|
US5786328A
(en)
*
|
1995-06-05 |
1998-07-28 |
Genentech, Inc. |
Use of kunitz type plasma kallikrein inhibitors
|
|
US5780265A
(en)
*
|
1995-06-05 |
1998-07-14 |
Genentech, Inc. |
Kunitz type plasma kallikrein inhibitors
|
|
US6242414B1
(en)
|
1995-06-07 |
2001-06-05 |
Chiron Corporation |
Regulation of cytokine synthesis and release
|
|
US6126933A
(en)
|
1995-06-27 |
2000-10-03 |
Genetics Institute |
Methods of treating inflammatory bowel diseases by administering IL-11
|
|
US5672662A
(en)
*
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
JPH0959838A
(ja)
|
1995-08-24 |
1997-03-04 |
Kuraray Co Ltd |
紡績糸
|
|
US6004579A
(en)
*
|
1995-09-14 |
1999-12-21 |
Lxr Biotechnology, Inc. |
Compositions which inhibit apoptosis, methods of making the compositions and uses thereof
|
|
JP2000500120A
(ja)
*
|
1995-09-21 |
2000-01-11 |
ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション |
ポリ（エチレングリコール）と抗グルタミン酸デカルボキシラーゼ抗体の結合体の膵島細胞指向ターゲット化
|
|
US5736364A
(en)
*
|
1995-12-04 |
1998-04-07 |
Genentech, Inc. |
Factor viia inhibitors
|
|
CA2247888A1
(en)
|
1996-03-11 |
1997-09-18 |
Bayer Corporation |
Human bikunin
|
|
US6013763A
(en)
*
|
1996-06-04 |
2000-01-11 |
Genentech, Inc. |
Peptide variants of protein A
|
|
US5869637A
(en)
*
|
1996-07-22 |
1999-02-09 |
Incyte Pharmaceuticals, Inc. |
Human Kallikrein
|
|
DE19632772A1
(de)
|
1996-08-14 |
1998-02-19 |
Basf Ag |
Neue Benzamidine
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
|
AU5702298A
(en)
|
1996-12-03 |
1998-06-29 |
Abgenix, Inc. |
Transgenic mammals having human Ig loci including plural VH and VK regions nd antibodies produced therefrom
|
|
CN1238366C
(zh)
|
1997-01-21 |
2006-01-25 |
综合医院公司 |
利用rna－蛋白融合体筛选蛋白
|
|
US5840871A
(en)
*
|
1997-01-29 |
1998-11-24 |
Incyte Pharmaceuticals, Inc. |
Prostate-associated kallikrein
|
|
AU6042298A
(en)
|
1997-01-31 |
1998-08-25 |
Human Genome Sciences, Inc. |
Tissue factor pathway inhibitor-3
|
|
US5962300A
(en)
|
1997-03-26 |
1999-10-05 |
Incyte Pharmaceuticals, Inc. |
Human kallikrein
|
|
DE69833755T2
(de)
|
1997-05-21 |
2006-12-28 |
Biovation Ltd. |
Verfahren zur herstellung von nicht-immunogenen proteinen
|
|
US5990237A
(en)
*
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
WO1999034833A1
(en)
|
1998-01-07 |
1999-07-15 |
Shearwater Polymers, Incorporated |
Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
|
|
PT1061954E
(pt)
|
1998-03-12 |
2004-10-29 |
Nektar Therapeutics Al Corp |
Derivados de poli(etileno glicol) com grupos reactivos proximos
|
|
DE69929311T2
(de)
|
1998-03-24 |
2006-09-07 |
Nof Corp. |
Oximanderivate und verfahren zu ihrer herstellung
|
|
US6017723A
(en)
*
|
1998-03-27 |
2000-01-25 |
Long Island Jewish Medical Center |
Method for isolating inhibitors of protease activity
|
|
JP2002510505A
(ja)
|
1998-04-03 |
2002-04-09 |
フィロス インク． |
位置特定可能な蛋白質アレイ
|
|
US6001596A
(en)
*
|
1998-05-07 |
1999-12-14 |
Incyte Pharmaceuticals, Inc. |
Growth-associated protease inhibitor heavy chain precursor
|
|
US6087473A
(en)
*
|
1999-05-26 |
2000-07-11 |
Zymogenetics, Inc. |
Kunitz domain polypeptide and materials and methods for making it
|
|
AU4229599A
(en)
|
1998-06-03 |
1999-12-20 |
Scios Inc. |
Protease inhibitor peptides
|
|
US6034053A
(en)
|
1998-07-13 |
2000-03-07 |
Wayne Hughes Institute |
EGF-isoflavone conjugates for the prevention of restenosis
|
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
ES2404074T3
(es)
|
1998-08-06 |
2013-05-23 |
Mountain View Pharmaceuticals, Inc. |
Conjugados de peg-oxidasa de urato y su uso
|
|
CA2342072C
(en)
|
1998-09-03 |
2005-01-11 |
Zymogenetics, Inc. |
Kunitz domain polypeptide zkun6
|
|
US7067144B2
(en)
|
1998-10-20 |
2006-06-27 |
Omeros Corporation |
Compositions and methods for systemic inhibition of cartilage degradation
|
|
US6114382A
(en)
|
1998-11-11 |
2000-09-05 |
Moretti; Itagiba G. |
Methods for treating inflammatory bowel disease
|
|
CA2352538A1
(en)
|
1998-11-30 |
2000-06-08 |
Eli Lilly And Company |
Erythropoietic compounds
|
|
CN1202128C
(zh)
|
1998-12-08 |
2005-05-18 |
拜奥威神有限公司 |
修饰蛋白的免疫原性
|
|
US6610503B1
(en)
|
1999-03-17 |
2003-08-26 |
Xenogen Corporation |
Animal models for predicting sepsis mortality
|
|
US20030012969A1
(en)
|
1999-04-06 |
2003-01-16 |
Clark Bert Thomas |
Soluble membrane strengthened paper products
|
|
US6605316B1
(en)
|
1999-07-31 |
2003-08-12 |
The Regents Of The University Of California |
Structures and fabrication techniques for solid state electrochemical devices
|
|
US6180607B1
(en)
|
1999-08-05 |
2001-01-30 |
Christopher Davies |
Protein having proteinase inhibitor activity
|
|
KR100942863B1
(ko)
*
|
1999-08-24 |
2010-02-17 |
메다렉스, 인코포레이티드 |
인간 씨티엘에이-4 항체 및 그의 용도
|
|
HUP0203409A3
(en)
|
1999-11-12 |
2005-06-28 |
Maxygen Holdings Ltd Redwood C |
Interferon gamma conjugates
|
|
GB9928787D0
(en)
|
1999-12-03 |
2000-02-02 |
Medical Res Council |
Direct screening method
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
US6544760B2
(en)
|
1999-12-22 |
2003-04-08 |
Zymogenetics, Inc. |
Kunitz domain polypeptide Zkun11
|
|
DK1259563T4
(en)
|
1999-12-22 |
2016-11-21 |
Nektar Therapeutics |
PROCEDURE FOR PREPARING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF WATER SOLUBLE POLYMERS
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US20020102703A1
(en)
|
1999-12-29 |
2002-08-01 |
Sheppard Paul O. |
Kunitz domain polypeptide zkun10
|
|
GB9930882D0
(en)
|
1999-12-30 |
2000-02-23 |
Nps Allelix Corp |
GLP-2 formulations
|
|
EP1274731A1
(en)
|
2000-03-13 |
2003-01-15 |
Eli Lilly And Company |
Human hepatocyte growth factor activator inhibitor homologue
|
|
EP1278544A4
(en)
|
2000-04-12 |
2004-08-18 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
|
CN1331213A
(zh)
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人大蛋白10.01和编码这种多肽的多核苷酸
|
|
DE10034357C1
(de)
|
2000-07-14 |
2001-12-13 |
Elotherm Gmbh |
Verfahren und Vorrichtung zum Härten von Flächen an Bauteilen
|
|
BR0115020A
(pt)
|
2000-10-31 |
2003-12-23 |
Deobiopharm S A |
Suspensão de uma proteìna epi-hne, processo de preparação da mesma, aerossol de pó seco derivado da mesma, composições farmacêuticas contendo a suspensão referida ou o aerossol referido, e suas aplicações
|
|
US20030113726A1
(en)
|
2000-12-04 |
2003-06-19 |
Zenta Tsuchihashi |
Human single nucleotide polymorphisms
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
JP2004531550A
(ja)
|
2001-05-11 |
2004-10-14 |
アラダイム コーポレーション |
吸入によって送達されるタンパク質の、分子性状の最適化方法および製剤
|
|
MXPA03010649A
(es)
|
2001-05-21 |
2005-10-05 |
Nektar Therapeutics |
Administracion pulmonar de insulina modificada quimicamente.
|
|
US20040152633A1
(en)
|
2001-05-31 |
2004-08-05 |
Jorgensen Marianne Ulrich |
Kunitz-type sequences and polypeptides
|
|
WO2003033009A2
(en)
|
2001-07-10 |
2003-04-24 |
Omnio Ab |
Novel drug targets for arthritis
|
|
CN100366965C
(zh)
|
2001-07-10 |
2008-02-06 |
日本电产三协株式会社 |
阀驱动设备
|
|
US6913900B2
(en)
*
|
2001-08-29 |
2005-07-05 |
Nippon Zoki Pharmaceutical Co., Ltd. |
Plasma prekallikrein activation and kallikrein production assay
|
|
PT1438400E
(pt)
|
2001-10-01 |
2009-09-10 |
Dyax Corp |
Vectores de apresentação eucarióticos de cadeias múltiplas e suas utilizações
|
|
WO2003035842A2
(en)
|
2001-10-24 |
2003-05-01 |
Dyax Corporation |
Hybridization control of sequence variation
|
|
JP4653915B2
(ja)
|
2001-10-29 |
2011-03-16 |
独立行政法人科学技術振興機構 |
全身性エリテマトーデスモデル非ヒト動物
|
|
KR100913714B1
(ko)
|
2001-11-08 |
2009-08-24 |
패시트 바이오테크 코포레이션 |
Ｉｇｇ 항체의 안정한 액상 약학 제형물
|
|
KR20110014661A
(ko)
|
2002-02-07 |
2011-02-11 |
노보자임스 바이오파마 디케이 에이/에스 |
알부민-융합 쿠니츠 도메인 펩타이드
|
|
US7153829B2
(en)
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
|
WO2003103475A2
(en)
|
2002-06-07 |
2003-12-18 |
Dyax Corp. |
Prevention and reduction of blood loss
|
|
US7132100B2
(en)
|
2002-06-14 |
2006-11-07 |
Medimmune, Inc. |
Stabilized liquid anti-RSV antibody formulations
|
|
RU2296769C2
(ru)
|
2002-07-24 |
2007-04-10 |
Ф.Хоффманн-Ля Рош Аг |
Пэгилированный полипептид т20
|
|
CN100337689C
(zh)
|
2002-07-24 |
2007-09-19 |
弗·哈夫曼-拉罗切有限公司 |
聚亚烷基二醇酸加合物
|
|
SI2386310T1
(sl)
|
2002-08-28 |
2019-03-29 |
Dyax Corp. |
Metode za ohranjanje organov in tkiv
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
RS20050502A
(en)
|
2002-12-26 |
2007-08-03 |
Mountain View Pharmaceuticals Inc., |
Polymer conjugates of interferon- beta with enhanced biological potency
|
|
US20040209243A1
(en)
|
2003-01-07 |
2004-10-21 |
Andrew Nixon |
Kunitz domain library
|
|
ES2311789T3
(es)
|
2003-01-08 |
2009-02-16 |
Novartis Vaccines And Diagnostics, Inc. |
Composiciones liofilizadas estabilizadas que comprenden inhibidor de la via del factor tisular o variantes del inhibidor de la via del factor tisular.
|
|
ATE424215T1
(de)
|
2003-01-08 |
2009-03-15 |
Novartis Vaccines & Diagnostic |
Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante
|
|
US6989369B2
(en)
|
2003-02-07 |
2006-01-24 |
Dyax Corp. |
Kunitz domain peptides
|
|
GB0303085D0
(en)
|
2003-02-11 |
2003-03-19 |
Pfizer Ltd |
Model
|
|
CA2535859A1
(en)
|
2003-08-14 |
2005-03-03 |
Dyax Corp. |
Endotheliase-2 ligands
|
|
CA2537113A1
(en)
|
2003-08-29 |
2005-03-10 |
Dyax Corp. |
Modified protease inhibitors
|
|
WO2005021557A2
(en)
|
2003-08-29 |
2005-03-10 |
Dyax Corp. |
Poly-pegylated protease inhibitors
|
|
EP1674480A4
(en)
*
|
2003-09-04 |
2007-06-20 |
Riken |
ANTIBODY RECOGNIZING THE REGIONAL SECTION CONTROLLING TGF-BETA ACTIVATION
|
|
WO2005027753A1
(en)
|
2003-09-19 |
2005-03-31 |
St. Jude Medical, Inc. |
Apparatus and methods for tissue gathering and securing
|
|
WO2005032556A1
(en)
|
2003-10-02 |
2005-04-14 |
Elan Pharmaceuticals, Inc. |
Method for reducing pain
|
|
US20060228331A1
(en)
|
2003-10-10 |
2006-10-12 |
Novo Nordisk A/S |
IL-21 Derivatives and variants
|
|
US20050164945A1
(en)
|
2003-10-21 |
2005-07-28 |
Andrew Nixon |
Endotheliase-1 ligands
|
|
US20070253949A1
(en)
|
2004-02-03 |
2007-11-01 |
Stefan Golz |
Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1)
|
|
EP1807451A2
(en)
|
2004-08-03 |
2007-07-18 |
Dyax Corporation |
Hk1-binding proteins
|
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
|
JP2008520729A
(ja)
|
2004-11-22 |
2008-06-19 |
ダイアックス コーポレーション |
プラスミン阻害療法
|
|
CN101102819A
(zh)
|
2004-12-23 |
2008-01-09 |
Csl百灵有限公司 |
血栓的形成和/或稳定化的预防
|
|
US20060183771A1
(en)
|
2005-02-17 |
2006-08-17 |
Seiffert Dietmar A |
Novel combination of selective factor VIIa and/or factor XIa inhibitors and selective plasma kallikrein inhibitors
|
|
EP2295452A1
(en)
|
2005-05-04 |
2011-03-16 |
Zealand Pharma A/S |
Glucagon-like-peptide-2 (GLP-2) analogues
|
|
US20070079096A1
(en)
|
2005-09-30 |
2007-04-05 |
Chih-Wei Chen |
Data storage unit access authorization table automatic rebuilding method and system
|
|
PT1981519T
(pt)
|
2005-12-29 |
2018-02-23 |
Dyax Corp |
Inibição de protéases
|
|
US7276480B1
(en)
|
2005-12-30 |
2007-10-02 |
Dyax Corp. |
Prevention and reduction of blood loss
|
|
CA2643693A1
(en)
|
2006-03-10 |
2007-09-20 |
Dyax Corp. |
Formulations for ecallantide
|
|
HUE031701T2
(en)
|
2006-03-16 |
2017-07-28 |
Dyax Corp |
Plasma kallikrein inhibiting peptides for use in treating eye diseases
|
|
EP1873344A1
(de)
|
2006-06-30 |
2008-01-02 |
Sika Technology AG |
Mittels Silikon agedichtete Verklebung
|
|
AU2007281220B2
(en)
*
|
2006-07-31 |
2013-08-15 |
Activesite Pharmaceuticals, Inc. |
Inhibitors of plasma kallikrein
|
|
WO2008060764A2
(en)
|
2006-10-05 |
2008-05-22 |
Drugtech Corporation |
Topical therapies for oral mucositis and other conditions
|
|
KR100846354B1
(ko)
|
2007-03-21 |
2008-07-15 |
(주) 프로탄바이오 |
혈청 당단백질부터 분리한 폐암 진단용 마커
|
|
WO2009026334A2
(en)
|
2007-08-21 |
2009-02-26 |
Genzyme Corporation |
Treatment with kallikrein inhibitors
|
|
US20090105142A1
(en)
|
2007-08-23 |
2009-04-23 |
Genzyme Corporation |
Treatment with kallikrein inhibitors
|
|
US8359965B2
(en)
|
2007-09-17 |
2013-01-29 |
Oxford J Craig |
Apparatus and method for broad spectrum radiation attenuation
|
|
JP2011511647A
(ja)
|
2008-02-13 |
2011-04-14 |
ダイアックス コーポレイション |
特異的結合対を作製するための改善された方法
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
DE102008033095A1
(de)
|
2008-07-15 |
2010-01-28 |
Uhde Gmbh |
Vorrichtung zur Schlackeabführung aus einem Kohlevergasungsreaktor
|
|
CN102307594A
(zh)
*
|
2009-01-06 |
2012-01-04 |
戴埃克斯有限公司 |
用激肽释放酶抑制剂治疗粘膜炎
|
|
CN101928346B
(zh)
|
2009-07-31 |
2013-01-16 |
华中科技大学同济医学院附属同济医院 |
一种抗人组织激肽释放酶单克隆抗体及其制备
|
|
HUE039605T2
(hu)
|
2010-01-06 |
2019-01-28 |
Dyax Corp |
Plazma kallikreint kötõ proteinek
|
|
KR102320178B1
(ko)
|
2011-01-06 |
2021-11-02 |
다케다 파머수티컬 컴패니 리미티드 |
혈장 칼리크레인 결합 단백질
|
|
WO2012142308A1
(en)
|
2011-04-13 |
2012-10-18 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
WO2012151247A2
(en)
|
2011-05-02 |
2012-11-08 |
Millennium Pharmaceuticals, Inc. |
FORMULATION FOR ANTI-α4β7 ANTIBODY
|
|
US9216219B2
(en)
|
2012-06-12 |
2015-12-22 |
Novartis Ag |
Anti-BAFFR antibody formulation
|
|
PT2946206T
(pt)
|
2013-01-20 |
2019-04-22 |
Dyax Corp |
Avaliação, ensaios e tratamento de distúrbios mediados por pkal
|
|
CA3209608A1
(en)
|
2013-01-20 |
2014-07-24 |
Takeda Pharmaceutical Company Limited |
Evaluation and treatment of pkal-mediated disorders
|
|
CA2906624A1
(en)
|
2013-03-15 |
2014-09-25 |
Dyax Corp. |
Anti-plasma kallikrein antibodies
|
|
KR20140119396A
(ko)
|
2013-03-29 |
2014-10-10 |
삼성전자주식회사 |
단백질 약물의 액상 제형
|
|
CA2937329C
(en)
|
2014-01-21 |
2022-05-31 |
Dyax Corp. |
Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
|
|
WO2015148790A1
(en)
|
2014-03-27 |
2015-10-01 |
Dyax Corp. |
Compositions and methods for treatment of diabetic macular edema
|
|
EP3286226A4
(en)
|
2015-03-30 |
2018-12-05 |
Dyax Corp. |
Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack
|
|
NZ744233A
(en)
|
2015-12-11 |
2023-11-24 |
Takeda Pharmaceuticals Co |
Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
|
|
CA3133576A1
(en)
|
2019-03-14 |
2020-09-17 |
Takeda Pharmaceutical Company Limited |
Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
|