ATE424215T1 - Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante - Google Patents
Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-varianteInfo
- Publication number
- ATE424215T1 ATE424215T1 AT04700828T AT04700828T ATE424215T1 AT E424215 T1 ATE424215 T1 AT E424215T1 AT 04700828 T AT04700828 T AT 04700828T AT 04700828 T AT04700828 T AT 04700828T AT E424215 T1 ATE424215 T1 AT E424215T1
- Authority
- AT
- Austria
- Prior art keywords
- tfpi
- tissue factor
- factor inhibitor
- variant
- aqueous compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43851903P | 2003-01-08 | 2003-01-08 | |
US49457703P | 2003-08-13 | 2003-08-13 | |
US50926003P | 2003-10-08 | 2003-10-08 | |
US51209003P | 2003-10-20 | 2003-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE424215T1 true ATE424215T1 (de) | 2009-03-15 |
Family
ID=32719506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04700828T ATE424215T1 (de) | 2003-01-08 | 2004-01-08 | Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante |
Country Status (15)
Country | Link |
---|---|
US (2) | US20040224886A1 (de) |
EP (2) | EP1599222B1 (de) |
JP (1) | JP2006515882A (de) |
CN (1) | CN1756559B (de) |
AT (1) | ATE424215T1 (de) |
AU (1) | AU2004204720B2 (de) |
CA (1) | CA2512681A1 (de) |
CY (1) | CY1109096T1 (de) |
DE (1) | DE602004019761D1 (de) |
DK (1) | DK1599222T3 (de) |
EA (1) | EA008038B1 (de) |
ES (1) | ES2321297T3 (de) |
PT (1) | PT1599222E (de) |
SI (1) | SI1599222T1 (de) |
WO (1) | WO2004062689A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US7375216B2 (en) * | 2002-06-04 | 2008-05-20 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin compounds |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
PT2311432E (pt) | 2002-06-07 | 2015-02-09 | Dyax Corp | Polipeptídeos de domínio kunitz modificado e sua utilização para a redução de isquemia ou aparecimento de uma resposta inflamatória sistémica associada a um procedimento cirúrgico |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
DK1542710T3 (da) | 2002-08-28 | 2012-10-15 | Dyax Corp | Fremgangsmåde til konservering af organer og væv |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
JP2008528509A (ja) * | 2005-01-21 | 2008-07-31 | アルザ コーポレイション | 少なくとも1つの対イオンを含む、向上した安定性でマイクロニードルをコーティングするための治療用ペプチド製剤 |
SG158920A1 (en) * | 2005-01-27 | 2010-02-26 | Advanced Tech Materials | Compositions for processing of semiconductor substrates |
US20060222668A1 (en) * | 2005-04-01 | 2006-10-05 | Wellspring Pharmaceutical Corporation | Stannsoporfin compositions, drug products and methods of manufacture |
US8088728B2 (en) * | 2005-06-24 | 2012-01-03 | Drugrecure Aps | Airway administration of tissue factor pathway inhibitor in inflammatory conditions affecting the respiratory tract |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
WO2008005071A1 (en) * | 2006-03-03 | 2008-01-10 | Novartis Ag | Cell-based assay for measuring anti-proliferative activity of oxidized tfpi |
WO2007103425A2 (en) * | 2006-03-06 | 2007-09-13 | Novartis Ag | Kits and methods for preparing pharmaceutical compositions comprising tissue factor pathway inhibitor (tfpi) |
WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
NZ571757A (en) | 2006-04-21 | 2012-01-12 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer |
EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
CA2810839A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EA030262B1 (ru) | 2006-10-04 | 2018-07-31 | Инфакэар Фармасьютикал Корпорейшн | Способ введения олова в соединение порфирина |
US7951368B2 (en) * | 2007-06-25 | 2011-05-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
JP4999613B2 (ja) * | 2007-08-31 | 2012-08-15 | シスメックス株式会社 | 血液凝固測定用試薬及び血液凝固時間測定方法 |
JP5551601B2 (ja) * | 2007-11-01 | 2014-07-16 | メルク セローノ ソシエテ アノニム | Lh液体調製物 |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
AU2010203712A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
JP2011001273A (ja) * | 2009-06-16 | 2011-01-06 | Eci Inc | eMIPを有効成分とする水溶性製剤 |
CN107115530A (zh) | 2009-11-27 | 2017-09-01 | 勃林格殷格翰国际有限公司 | 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗 |
WO2011073389A1 (en) * | 2009-12-18 | 2011-06-23 | Novartis Ag | Wash solution and method for affinity chromatography |
LT2521568T (lt) | 2010-01-06 | 2018-12-10 | Dyax Corp. | Plazmos kalikreiną surišantys baltymai |
KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
CN102971005A (zh) | 2010-06-24 | 2013-03-13 | 贝林格尔.英格海姆国际有限公司 | 糖尿病治疗 |
JO3400B1 (ar) | 2010-09-30 | 2019-10-20 | Ferring Bv | مركب صيدلاني من كاربيتوسين |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
CN105713092B (zh) | 2011-01-06 | 2019-09-10 | 戴埃克斯有限公司 | 血浆前激肽释放酶结合蛋白 |
PT3287123T (pt) | 2011-03-04 | 2020-05-22 | Gruenenthal Gmbh | Formulação farmacêutica aquosa de tapentadol para administração oral |
EP2691398B1 (de) | 2011-03-30 | 2016-09-28 | InfaCare Pharmaceutical Corporation | Verfahren zur herstellung von mesoporphyrinen |
EP3517539B1 (de) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituiertes dimeres chinazolinderivat, dessen herstellung und dessen verwendung in pharmazeutischen zusammensetzungen zur behandlung von diabetes typ i und ii |
CA2951856A1 (en) | 2011-10-28 | 2013-05-02 | Integritybio Inc. | Protein formulations containing amino acids |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
JP2016506389A (ja) * | 2012-12-06 | 2016-03-03 | トビラ・セラピューティクス・インコーポレイテッド | オリゴヌクレオチド製剤 |
US20160058725A1 (en) * | 2013-03-15 | 2016-03-03 | Biochemics, Inc. | Topical Formulations and Methods for Drug Delivery |
JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害薬の医学的使用 |
CN105153021A (zh) * | 2014-06-12 | 2015-12-16 | 浙江永宁药业股份有限公司 | 马来酸吡硫醇晶型及其制备方法 |
PL3273953T3 (pl) | 2015-03-27 | 2019-07-31 | Grünenthal GmbH | Stabilny preparat do pozajelitowego podawania tapentadolu |
AU2016366557B2 (en) | 2015-12-11 | 2024-01-25 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
MX2019003257A (es) | 2016-09-23 | 2019-06-10 | Gruenenthal Gmbh | Formulacion estable para la administracion parenteral de tapentadol. |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
EP0158487B1 (de) | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stabile Interleukin-2-Zusammensetzung |
US4650674A (en) | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
US5034225A (en) | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
JPH0645551B2 (ja) | 1986-01-07 | 1994-06-15 | 塩野義製薬株式会社 | インタ−ロイキン−2組成物 |
US4894226A (en) | 1986-11-14 | 1990-01-16 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polyproline conjugation |
US4931543A (en) | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
ES2044941T5 (es) | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
US4883661A (en) | 1987-10-09 | 1989-11-28 | Daly John M | Use of arginine as an lymphokine synergist |
US5078997A (en) | 1988-07-13 | 1992-01-07 | Cetus Corporation | Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers |
US5272135A (en) * | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
FR2684878B1 (fr) | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
IL107887A (en) | 1992-12-08 | 2003-07-06 | Ambi Inc | Stabilized lanthionine containing bacteriocin compositions |
US5358708A (en) | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
DE69528591T2 (de) * | 1994-08-05 | 2003-02-20 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
WO1996024369A1 (en) | 1995-02-06 | 1996-08-15 | Genetics Institute, Inc. | Formulations for il-12 |
SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
AU708394B2 (en) * | 1995-06-07 | 1999-08-05 | Novartis Vaccines And Diagnostics, Inc. | Regulation of cytokine synthesis and release |
US5888968A (en) * | 1995-06-07 | 1999-03-30 | Chiron Corporation | TFPI formulation |
ES2248818T3 (es) * | 1995-06-07 | 2006-03-16 | Chiron Corporation | Metodo de solubilizacion, purificacion y replegamiento de proteinas. |
US5977057A (en) * | 1996-05-08 | 1999-11-02 | The University Of Vermont And State Agricultural College | Thrombosis prophylaxis for factor VLEIDEN carriers |
CA2279345A1 (en) * | 1997-01-31 | 1998-08-06 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
WO1999051272A1 (en) | 1998-04-03 | 1999-10-14 | Chiron Corporation | Injectable igf-formulations containing succinate as buffering agent |
PL211886B1 (pl) * | 1999-10-04 | 2012-07-31 | Novartis Vaccines & Diagnostic | Stabilizowana ciekła kompozycja farmaceutyczna, sposób zwiększania trwałości polipeptydu, sposób zwiększania trwałości podczas przechowywania kompozycji, sucha postać kompozycji oraz preparat zawierający kompozycję |
AU1410801A (en) * | 1999-11-17 | 2001-05-30 | Compugen Ltd. | Variants of alternative splicing |
EP1282438B1 (de) * | 2000-05-10 | 2005-08-03 | Novo Nordisk Health Care AG | Verwendung von faktor vii-a und faktor xiii enthaltenden pharmazeutischen verbindungen |
DK1324776T4 (en) * | 2000-10-12 | 2018-05-28 | Genentech Inc | CONCENTRATED PROTEIN FORMULATIONS WITH REDUCED VISCOSITY |
CN1658903A (zh) * | 2001-01-26 | 2005-08-24 | 先灵公司 | 用于治疗血管性疾病的固醇吸收抑制剂与血液调节剂的组合 |
EP1390497A2 (de) * | 2001-05-25 | 2004-02-25 | Genset | Menschliche cdns und proteine und verwendungen davon |
-
2004
- 2004-01-08 PT PT04700828T patent/PT1599222E/pt unknown
- 2004-01-08 AT AT04700828T patent/ATE424215T1/de not_active IP Right Cessation
- 2004-01-08 EP EP04700828A patent/EP1599222B1/de not_active Expired - Lifetime
- 2004-01-08 US US10/753,068 patent/US20040224886A1/en not_active Abandoned
- 2004-01-08 AU AU2004204720A patent/AU2004204720B2/en not_active Ceased
- 2004-01-08 WO PCT/US2004/000233 patent/WO2004062689A1/en active Application Filing
- 2004-01-08 SI SI200431119T patent/SI1599222T1/sl unknown
- 2004-01-08 DK DK04700828T patent/DK1599222T3/da active
- 2004-01-08 ES ES04700828T patent/ES2321297T3/es not_active Expired - Lifetime
- 2004-01-08 JP JP2006500805A patent/JP2006515882A/ja active Pending
- 2004-01-08 EA EA200501097A patent/EA008038B1/ru not_active IP Right Cessation
- 2004-01-08 CN CN200480006044XA patent/CN1756559B/zh not_active Expired - Fee Related
- 2004-01-08 EP EP08075968A patent/EP2174663A1/de not_active Withdrawn
- 2004-01-08 CA CA002512681A patent/CA2512681A1/en not_active Abandoned
- 2004-01-08 DE DE602004019761T patent/DE602004019761D1/de not_active Expired - Lifetime
-
2005
- 2005-12-14 US US11/302,208 patent/US7659248B2/en not_active Expired - Fee Related
-
2009
- 2009-05-22 CY CY20091100554T patent/CY1109096T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1599222E (pt) | 2009-06-12 |
US7659248B2 (en) | 2010-02-09 |
DK1599222T3 (da) | 2009-04-27 |
CN1756559A (zh) | 2006-04-05 |
EA200501097A1 (ru) | 2006-04-28 |
US20060079459A1 (en) | 2006-04-13 |
US20040224886A1 (en) | 2004-11-11 |
CN1756559B (zh) | 2010-04-28 |
EP1599222B1 (de) | 2009-03-04 |
CY1109096T1 (el) | 2014-07-02 |
JP2006515882A (ja) | 2006-06-08 |
EP2174663A1 (de) | 2010-04-14 |
CA2512681A1 (en) | 2004-07-29 |
DE602004019761D1 (de) | 2009-04-16 |
ES2321297T3 (es) | 2009-06-04 |
WO2004062689A1 (en) | 2004-07-29 |
EP1599222A1 (de) | 2005-11-30 |
AU2004204720B2 (en) | 2009-08-06 |
EA008038B1 (ru) | 2007-02-27 |
AU2004204720A1 (en) | 2004-07-29 |
SI1599222T1 (sl) | 2009-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE424215T1 (de) | Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante | |
CO5700709A2 (es) | Forma de administracion de ibuprofeno sodico | |
EA200700240A1 (ru) | Композиция, содержащая статины и омега - 3 жирные кислоты | |
UY27787A1 (es) | Activadores cicloalquil sustituidos y cicloalquil oxigenados de glucoquinasa. | |
BRPI0402760A (pt) | Composição microbicida | |
DK1465498T3 (da) | Tyggegummi med fyld i midten indeholdende calcium | |
NO20034433L (no) | Atineoplastiske blandinger slik som rapamycin sammen med gemcitabin eller fluorouracil | |
BR0308465A (pt) | Cigarro de fumaça de baixo fluxo lateral com papel combustìvel tendo cinza modificada | |
AR109263A2 (es) | Composición que comprende moxidectina | |
DE502006003622D1 (de) | Kletterschalung mit angelenktem kletterschuh | |
AR035293A1 (es) | Composicion oftalmica. | |
EA200901443A1 (ru) | Фунгицидные смеси | |
GEP20084490B (en) | Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof | |
ATE515248T1 (de) | Dentalzusammensetzung mit einem enzym | |
DK1377164T3 (da) | Erythropoietin forbedrer kemoterapi-induceret toksicitet in vivo | |
AR034071A1 (es) | Combinaciones antineoplasicas | |
EP1883099A3 (de) | Beleuchtungsvorrichtung mit einer kompakten Struktur | |
AR057648A1 (es) | Composicion de metaflumizona para la administracion topica | |
ATE399558T1 (de) | Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln | |
ATE485038T1 (de) | Zusammensetzung gegen müdigkeit | |
AR038560A1 (es) | Una composicion antitranspirante/ desodorante | |
ES2510403T3 (es) | Composición antioxidante, sinérgica | |
AR043327A1 (es) | Uso de inhibidores de quinurenina 3- hidroxilasa para el tratamiento de la diabetes | |
AR045392A1 (es) | Composiciones para el tratamiento del cabello | |
BR0104779A (pt) | Taxanos substituìdos com carbonato c10 comoagentes antitumor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1599222 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |