ATE226249T1 - Herstellung des inhibitors fuer die komplexbildung des gewebefaktors - Google Patents

Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Info

Publication number
ATE226249T1
ATE226249T1 AT95926779T AT95926779T ATE226249T1 AT E226249 T1 ATE226249 T1 AT E226249T1 AT 95926779 T AT95926779 T AT 95926779T AT 95926779 T AT95926779 T AT 95926779T AT E226249 T1 ATE226249 T1 AT E226249T1
Authority
AT
Austria
Prior art keywords
tissue factor
production
inhibitor
complex formation
tfpi
Prior art date
Application number
AT95926779T
Other languages
English (en)
Inventor
Michael A Innis
Alba A Creasey
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE226249T1 publication Critical patent/ATE226249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT95926779T 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors ATE226249T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28653094A 1994-08-05 1994-08-05
PCT/US1995/009377 WO1996004377A1 (en) 1994-08-05 1995-07-25 Production of tissue factor pathway inhibitor

Publications (1)

Publication Number Publication Date
ATE226249T1 true ATE226249T1 (de) 2002-11-15

Family

ID=23099037

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95926779T ATE226249T1 (de) 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Country Status (8)

Country Link
US (2) US6103500A (de)
EP (1) EP0774001B1 (de)
JP (2) JP3779728B2 (de)
AT (1) ATE226249T1 (de)
AU (1) AU707762B2 (de)
CA (1) CA2196296C (de)
DE (1) DE69528591T2 (de)
WO (1) WO1996004377A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
JP3779728B2 (ja) * 1994-08-05 2006-05-31 カイロン コーポレイション 組織因子活性インヒビターの産生
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
ES2276396T3 (es) 1994-10-18 2007-06-16 Dendreon Corporation Proteinas anticoagulantes e inhibidores de la serina proteasa extraidos de nematodos.
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
EP1602667B1 (de) * 1995-06-07 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Waessrige Formulierung enthaltend TFPI und Lösungsvermittlers
EP0791358B1 (de) * 1995-08-09 2002-01-16 Toray Industries, Inc. Medikament gegen ophthalmische erkrankungen
WO1998042850A1 (en) * 1997-03-26 1998-10-01 Rpms Technology Limited Anticoagulant fusion protein anchored to cell membrane
CA2488558C (en) 2002-06-07 2013-08-20 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
EP1599222B1 (de) * 2003-01-08 2009-03-04 Novartis Vaccines and Diagnostics, Inc. Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante
WO2005014825A2 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
EP1654283B1 (de) * 2003-08-13 2011-07-13 Novartis Vaccines and Diagnostics, Inc. Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen
ES2375706T3 (es) * 2003-11-14 2012-03-05 Baxter International Inc. Composiciones de alfa 1-antitripsina y métodos de tratamiento que usan tales composiciones.
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1799243B1 (de) * 2004-10-06 2015-07-15 University Of Rochester Behandlung pulmonalen hochdrucks mit einem wirkstoff, der als gewebefaktorinhibitor fungiert
US20080090760A2 (en) * 2005-12-09 2008-04-17 Todd Hembrough Compositions and Methods for Inhibiting Cellular Proliferation
PT1981519T (pt) 2005-12-29 2018-02-23 Dyax Corp Inibição de protéases
CN100451116C (zh) * 2006-09-14 2009-01-14 中国医学科学院生物医学工程研究所 人类组织因子途径抑制因子突变基因mTFPI、包括该基因的重组载体及其宿主细胞
EP2195010A4 (de) * 2007-08-21 2012-03-14 Genzyme Corp Behandlung mit kallikrein-inhibitoren
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US8088599B2 (en) * 2009-02-06 2012-01-03 Fudan University Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
RS62853B1 (sr) 2010-01-06 2022-02-28 Takeda Pharmaceuticals Co Proteini koji vezuju kalikrein plazme
AU2012204202A1 (en) 2011-01-06 2013-07-11 Dyax Corp. Plasma kallikrein binding proteins
AU2015235967B2 (en) 2014-03-27 2020-10-22 Takeda Pharmaceutical Company Limited Compositions and methods for treatment of diabetic macular edema
CN116077648A (zh) 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途
MX2022008649A (es) 2020-01-13 2022-09-23 Takeda Pharmaceuticals Co Inhibidores de calicreina plasmatica y sus usos para tratar episodios de angioedema hereditario pediatrico.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
DK0473564T3 (da) * 1990-08-27 1996-04-15 Monsanto Co Antikoagulant kombination af LACI og sulfatiserede polysaccharider
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
JP3779728B2 (ja) * 1994-08-05 2006-05-31 カイロン コーポレイション 組織因子活性インヒビターの産生

Also Published As

Publication number Publication date
WO1996004377A1 (en) 1996-02-15
DE69528591T2 (de) 2003-02-20
JPH10507071A (ja) 1998-07-14
CA2196296C (en) 2004-04-06
EP0774001B1 (de) 2002-10-16
US6103500A (en) 2000-08-15
AU707762B2 (en) 1999-07-22
DE69528591D1 (de) 2002-12-05
AU3104495A (en) 1996-03-04
JP2005348744A (ja) 2005-12-22
JP3779728B2 (ja) 2006-05-31
EP0774001A1 (de) 1997-05-21
US20050064556A1 (en) 2005-03-24
CA2196296A1 (en) 1996-02-15

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Legal Events

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