DE69528591D1 - Herstellung des inhibitors fuer die komplexbildung des gewebefaktors - Google Patents

Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Info

Publication number
DE69528591D1
DE69528591D1 DE69528591T DE69528591T DE69528591D1 DE 69528591 D1 DE69528591 D1 DE 69528591D1 DE 69528591 T DE69528591 T DE 69528591T DE 69528591 T DE69528591 T DE 69528591T DE 69528591 D1 DE69528591 D1 DE 69528591D1
Authority
DE
Germany
Prior art keywords
tissue factor
production
inhibitor
complex formation
tfpi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528591T
Other languages
English (en)
Other versions
DE69528591T2 (de
Inventor
A Innis
A Creasey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69528591D1 publication Critical patent/DE69528591D1/de
Publication of DE69528591T2 publication Critical patent/DE69528591T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69528591T 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors Expired - Fee Related DE69528591T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28653094A 1994-08-05 1994-08-05
PCT/US1995/009377 WO1996004377A1 (en) 1994-08-05 1995-07-25 Production of tissue factor pathway inhibitor

Publications (2)

Publication Number Publication Date
DE69528591D1 true DE69528591D1 (de) 2002-12-05
DE69528591T2 DE69528591T2 (de) 2003-02-20

Family

ID=23099037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528591T Expired - Fee Related DE69528591T2 (de) 1994-08-05 1995-07-25 Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Country Status (8)

Country Link
US (2) US6103500A (de)
EP (1) EP0774001B1 (de)
JP (2) JP3779728B2 (de)
AT (1) ATE226249T1 (de)
AU (1) AU707762B2 (de)
CA (1) CA2196296C (de)
DE (1) DE69528591T2 (de)
WO (1) WO1996004377A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP0774001B1 (de) * 1994-08-05 2002-10-16 Chiron Corporation Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
WO1996012021A2 (en) * 1994-10-18 1996-04-25 Corvas International, Inc. Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
DK0837883T3 (da) * 1995-06-07 2005-12-19 Chiron Corp Fremgangsmåde til oplösning, oprensning og genfoldning af protein
WO1997005893A1 (fr) * 1995-08-09 1997-02-20 Toray Industries, Inc. Remede contre les troubles ophtalmiques
KR100561055B1 (ko) * 1997-03-26 2006-03-16 임페리얼 컬리지 이노베이션스 리미티드 세포막에 고정된 항 혈액응고성 융합단백질
WO2003103475A2 (en) 2002-06-07 2003-12-18 Dyax Corp. Prevention and reduction of blood loss
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ATE424215T1 (de) * 2003-01-08 2009-03-15 Novartis Vaccines & Diagnostic Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante
WO2005014825A2 (en) * 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US7851433B2 (en) * 2003-08-13 2010-12-14 Novartis Vaccines And Diagnostics, Inc. Method of purifying TFPI and TFPI analogs
DK1684719T3 (da) * 2003-11-14 2012-01-30 Baxter Int Alfa-1-antitrypsin-sammensætninger og behandlingsfremgangsmåder, der anvender sådanne sammensætninger
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8563511B2 (en) * 2004-10-06 2013-10-22 University Of Rochester Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
WO2007070372A2 (en) * 2005-12-09 2007-06-21 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
PT1981519T (pt) 2005-12-29 2018-02-23 Dyax Corp Inibição de protéases
CN100451116C (zh) * 2006-09-14 2009-01-14 中国医学科学院生物医学工程研究所 人类组织因子途径抑制因子突变基因mTFPI、包括该基因的重组载体及其宿主细胞
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
CN102307594A (zh) * 2009-01-06 2012-01-04 戴埃克斯有限公司 用激肽释放酶抑制剂治疗粘膜炎
US8088599B2 (en) * 2009-02-06 2012-01-03 Fudan University Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
HUE039605T2 (hu) 2010-01-06 2019-01-28 Dyax Corp Plazma kallikreint kötõ proteinek
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
WO2015148790A1 (en) 2014-03-27 2015-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
NZ744233A (en) 2015-12-11 2023-11-24 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
ES2085462T3 (es) * 1990-08-27 1996-06-01 Monsanto Co Combinacion anticoagulante de laci y de polisacaridos sulfatados.
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104326A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
US5212091A (en) * 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
EP0774001B1 (de) * 1994-08-05 2002-10-16 Chiron Corporation Herstellung des inhibitors fuer die komplexbildung des gewebefaktors

Also Published As

Publication number Publication date
ATE226249T1 (de) 2002-11-15
EP0774001A1 (de) 1997-05-21
JP3779728B2 (ja) 2006-05-31
CA2196296C (en) 2004-04-06
DE69528591T2 (de) 2003-02-20
US6103500A (en) 2000-08-15
JPH10507071A (ja) 1998-07-14
CA2196296A1 (en) 1996-02-15
JP2005348744A (ja) 2005-12-22
WO1996004377A1 (en) 1996-02-15
AU3104495A (en) 1996-03-04
EP0774001B1 (de) 2002-10-16
US20050064556A1 (en) 2005-03-24
AU707762B2 (en) 1999-07-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US

8339 Ceased/non-payment of the annual fee