WO1994007527A3 - Vasoactive peptide inhibition - Google Patents

Vasoactive peptide inhibition Download PDF

Info

Publication number
WO1994007527A3
WO1994007527A3 PCT/GB1993/002044 GB9302044W WO9407527A3 WO 1994007527 A3 WO1994007527 A3 WO 1994007527A3 GB 9302044 W GB9302044 W GB 9302044W WO 9407527 A3 WO9407527 A3 WO 9407527A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyamino
phenylalanine
endothelin
isobutylsuccinyl
methylamide
Prior art date
Application number
PCT/GB1993/002044
Other languages
French (fr)
Other versions
WO1994007527A2 (en
Inventor
Michael John Crimmin
Elisabeth Ann Bone
Lars Michael Wood
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology filed Critical British Bio Technology
Priority to AU48316/93A priority Critical patent/AU4831693A/en
Publication of WO1994007527A2 publication Critical patent/WO1994007527A2/en
Publication of WO1994007527A3 publication Critical patent/WO1994007527A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids

Abstract

Certain known hydroxamic acid derivatives and their salts are useful as inhibitors of the conversion of Big Endothelin to Endothelin by a putative endothelin converting enzyme, and are useful in the management of diseases mediated by overproduction of, or over-responsiveness to, endothelin in mammals. Examples of such compounds are [4-(N-Hydroxyamino)-2R-isobutylsuccinyl]-L-phenylalanine; [4-(N-Hydroxyamino)-2R-isobutylsuccinyl]-4-(oxymethylenecarboxyethyl)-L-phenylalanine-N-methylamide; [4-(N-Hydroxyamino)-2R-isobutylsuccinyl]-4-(oxymethylenecarboxamido)-L-phenylalanine-N-methylamide; and [4-(N-Hydroxyamino)-2R-isopropylsuccinyl]-L-phenylalanine.
PCT/GB1993/002044 1992-10-03 1993-10-01 Vasoactive peptide inhibition WO1994007527A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU48316/93A AU4831693A (en) 1992-10-03 1993-10-01 Vasoactive peptide inhibition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929220845A GB9220845D0 (en) 1992-10-03 1992-10-03 Vasoactive peptide inhibition
GB9220845.3 1992-10-03

Publications (2)

Publication Number Publication Date
WO1994007527A2 WO1994007527A2 (en) 1994-04-14
WO1994007527A3 true WO1994007527A3 (en) 1994-07-21

Family

ID=10722928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/002044 WO1994007527A2 (en) 1992-10-03 1993-10-01 Vasoactive peptide inhibition

Country Status (3)

Country Link
AU (1) AU4831693A (en)
GB (1) GB9220845D0 (en)
WO (1) WO1994007527A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
CN1298299A (en) 1998-02-07 2001-06-06 英国生物技术药物有限公司 Antibacterial agents
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
ATE293600T1 (en) * 1999-08-10 2005-05-15 Vernalis Oxford Ltd ANTIBACTERIAL AGENTS
CN103435514B (en) * 2013-08-01 2015-11-25 中国人民解放军军事医学科学院毒物药物研究所 Matrix metallo-proteinase inhibitor and uses thereof
WO2023235109A1 (en) * 2022-06-01 2023-12-07 University Of Massachusetts Novel main protease inhibitors, and compositions and methods thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618708A (en) * 1981-12-16 1986-10-21 Bernard Roques Amino acid derivative
EP0214639A2 (en) * 1985-09-10 1987-03-18 G.D. Searle & Co. Hydroxamic acid based collagenase inhibitors
EP0236872A2 (en) * 1986-03-11 1987-09-16 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
WO1990005719A1 (en) * 1988-11-23 1990-05-31 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
EP0498665A1 (en) * 1991-02-07 1992-08-12 British Biotech Pharmaceuticals Limited Hydroxamic acids derivatives, process for their preparation and use thereof
WO1992013545A1 (en) * 1991-01-31 1992-08-20 Abbott Laboratories Endothelin converting enzyme inhibitors
WO1993020047A1 (en) * 1992-04-07 1993-10-14 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618708A (en) * 1981-12-16 1986-10-21 Bernard Roques Amino acid derivative
EP0214639A2 (en) * 1985-09-10 1987-03-18 G.D. Searle & Co. Hydroxamic acid based collagenase inhibitors
EP0236872A2 (en) * 1986-03-11 1987-09-16 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
WO1990005719A1 (en) * 1988-11-23 1990-05-31 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
WO1992013545A1 (en) * 1991-01-31 1992-08-20 Abbott Laboratories Endothelin converting enzyme inhibitors
EP0498665A1 (en) * 1991-02-07 1992-08-12 British Biotech Pharmaceuticals Limited Hydroxamic acids derivatives, process for their preparation and use thereof
WO1993020047A1 (en) * 1992-04-07 1993-10-14 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.H.AXELROD ET AL.: "Expression of Human Recombinant Pasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells", MOL.CELL.BIOL., vol. 9, no. 5, May 1989 (1989-05-01), pages 2133 - 2141 *
R.BERKOW, ED.: "the merck manual of diagnosis and therapy, 15th edition", MERCK & CO.,INC., RAHWAY, N.J. *
R.REICH ET AL.: "Effects of Inhibitors of Plasminogen Activator, Serine Proteinases, and Collagenase IV on the Invasion of Basement Membranes by Metastatic Cells", CANCER RES., vol. 48, no. 12, 1988, pages 3307 - 3312 *

Also Published As

Publication number Publication date
GB9220845D0 (en) 1992-11-18
WO1994007527A2 (en) 1994-04-14
AU4831693A (en) 1994-04-26

Similar Documents

Publication Publication Date Title
AU6072496A (en) Method for inhibiting adhesion of white blood cells to endothelial cells
MX9706069A (en) Novel dipeptide amidines as thrombin inhibitors.
AU3723095A (en) Inhibition of hair growth
AU8163398A (en) Inhibitors of alpha4beta1mediated cell adhesion
AU3563799A (en) Compounds that inhibit the binding of integrins to their receptors
CA2184173A1 (en) Inhibition of Hair Growth
CY1107438T1 (en) CARBOXYLIC ACID PRODUCERS THAT INHIBIT THE INTEGRINAL CONNECTION TO THEIR ACCEPTANCES
BG103977A (en) Low molecular rotamase enzymic activity inhibitors
NO963860L (en) Isoprenyl transferase inhibitors
MY129998A (en) Saccharin derivative proteolytic enzyme inhibitors
AU5665396A (en) Novel hydroxamic acid and amino-carboxylate compounds as met alloprotease and tnf inhibitors
DE69528591T2 (en) PRODUCTION OF THE INHIBITOR FOR THE COMPLEX FORMATION OF THE TISSUE FACTOR
BG101712A (en) Method for cathepsin k inhibition
BG103096A (en) Thrombin inhibitors
AU4269397A (en) Method of cell surface activation and inhibition
AU4826900A (en) Propanoic acid derivatives that inhibit the binding of integrins to their receptors
WO1994007527A3 (en) Vasoactive peptide inhibition
EP0220107A3 (en) Use of angiotensin-converting enzyme inhibitors in macular degeneration
WO2002015918A3 (en) Method and compositions for promoting osteogenesis
AU2001264769A1 (en) Induction of apoptosis and cell growth inhibition by protein 4.33
WO1994000555A3 (en) Compositions for the inhibition of protein hormone formation and uses thereof
AU4306197A (en) Use of inhibitors of the activity of retinoic acid to promote healing
MY143570A (en) Compounds useful for inhibition of farnesyl protein transferase
CA2238389A1 (en) Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
EP0635263A3 (en) Angiotensin (AII) antagonists as inhibitors of the growth of adipose tissue.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA FI GB JP KR NO NZ PT US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA FI GB JP KR NO NZ PT US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA