ATE216590T1 - Arzneimittelformulierungen für il-12 - Google Patents
Arzneimittelformulierungen für il-12Info
- Publication number
- ATE216590T1 ATE216590T1 AT96905322T AT96905322T ATE216590T1 AT E216590 T1 ATE216590 T1 AT E216590T1 AT 96905322 T AT96905322 T AT 96905322T AT 96905322 T AT96905322 T AT 96905322T AT E216590 T1 ATE216590 T1 AT E216590T1
- Authority
- AT
- Austria
- Prior art keywords
- drug formulations
- formulations
- administration
- methods
- storage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38406295A | 1995-02-06 | 1995-02-06 | |
PCT/US1996/001382 WO1996024369A1 (en) | 1995-02-06 | 1996-02-02 | Formulations for il-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE216590T1 true ATE216590T1 (de) | 2002-05-15 |
Family
ID=23515877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96905322T ATE216590T1 (de) | 1995-02-06 | 1996-02-02 | Arzneimittelformulierungen für il-12 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5744132A (de) |
EP (1) | EP0820299B1 (de) |
JP (1) | JP2000510813A (de) |
AT (1) | ATE216590T1 (de) |
AU (1) | AU695129B2 (de) |
DE (1) | DE69620877T2 (de) |
WO (1) | WO1996024369A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
PL193286B1 (pl) * | 1998-03-26 | 2007-01-31 | Schering Corp | Liofilizowany proszek koniugatów glikol polietylenowy - interferon-alfa i zawierające go wyroby |
US6180096B1 (en) | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
US20050059802A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Ltd | Prevention and treatment of amyloidogenic disease |
US6080399A (en) | 1998-04-23 | 2000-06-27 | Arch Development Corporation | Vaccine adjuvants for immunotherapy of melanoma |
JP4557098B2 (ja) * | 1999-03-31 | 2010-10-06 | 味の素株式会社 | 安定な6−アミジノ−2−ナフチル4−グアニジノベンゾエート酸付加塩製剤ならびにその製造方法 |
IL147599A0 (en) * | 1999-07-15 | 2002-08-14 | Genetics Inst | Formulations for il-11 |
US7090847B1 (en) | 1999-09-09 | 2006-08-15 | Schering Corporation | Mammalian cytokines; related reagents and methods |
EP3184637A1 (de) | 1999-09-09 | 2017-06-28 | Merck Sharp & Dohme Corp. | Komplexe aus säugetier-interleukin-12 p40 und interleukin b30, antikörper, verwendung in pharmazeutischen zusammensetzungen |
HU0800692D0 (en) * | 1999-10-04 | 2009-01-28 | Novartis Vaccines & Diagnostic | Stabilized liquid polypeptide-containing pharmaceutical compositions |
US7115712B1 (en) | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
EP1374898B1 (de) * | 2001-03-12 | 2007-06-27 | Institute of Gene and Brain Science | Verwendung von interleukin-12 zur behandlung von nervenschäden |
EP1412384B1 (de) | 2001-06-28 | 2007-12-26 | Novo Nordisk A/S | Stabile formulierung von modifiziertem glp-1 |
US20030129161A1 (en) * | 2001-09-17 | 2003-07-10 | Hsien-Jue Chu | Interleukin-12 as a veterinary vaccine adjuvant |
DE10149030A1 (de) * | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
DK1441589T3 (da) * | 2001-11-08 | 2012-08-06 | Abbott Biotherapeutics Corp | Stabil, flydende, farmaceutisk sammensætning af IgG-antistoffer |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US20040265943A1 (en) * | 2002-09-23 | 2004-12-30 | Aventis Pharma S.A. | Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins |
EP1599222B1 (de) | 2003-01-08 | 2009-03-04 | Novartis Vaccines and Diagnostics, Inc. | Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante |
KR20050118669A (ko) * | 2003-02-01 | 2005-12-19 | 뉴랄랩 리미티드 | 가용성 a-베타에 대한 항체를 생성하기 위한 능동 면역화 |
TWI306458B (en) * | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
PL1633391T3 (pl) | 2003-06-03 | 2012-03-30 | Novo Nordisk As | Stabilizowane farmaceutycznie kompozycje peptydowe |
US7939058B2 (en) | 2003-07-03 | 2011-05-10 | University Of Southern California | Uses of IL-12 in hematopoiesis |
RU2421238C2 (ru) | 2003-11-20 | 2011-06-20 | Ново Нордиск А/С | Пептидная композиция, содержащая пропиленгликоль, являющаяся оптимальной для изготовления и применения в инъекционных устройствах |
ATE476967T1 (de) | 2004-08-12 | 2010-08-15 | Schering Corp | Stabile pegylierte interferon-formulierung |
ES2395035T3 (es) * | 2004-08-17 | 2013-02-07 | Regeneron Pharmaceuticals, Inc. | Formulaciones de antagonistas de la IL-1 |
PL1817048T3 (pl) | 2004-11-12 | 2014-07-31 | Novo Nordisk As | Stabilne preparaty peptydów insulinotropowych |
WO2006066089A1 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
AR051800A1 (es) * | 2004-12-15 | 2007-02-07 | Wyeth Corp | Anticuerpos a beta usados en mejorar la cognicion |
TW200636066A (en) * | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized antibodies that recognize beta amyloid peptide |
KR20070107079A (ko) * | 2005-01-28 | 2007-11-06 | 와이어쓰 | 안정화된 액체 폴리펩타이드 제형 |
GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US9283260B2 (en) * | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
AU2011265555B2 (en) * | 2006-04-21 | 2016-03-10 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
US8367054B2 (en) * | 2006-11-24 | 2013-02-05 | Cadila Healthcare Limited | Formulations of PEG-interferon alpha conjugates |
JP2010519220A (ja) * | 2007-02-16 | 2010-06-03 | ワイス エルエルシー | マンニトール誘導性のタンパク質凝集を抑制するためのスクロースの使用 |
MX2009008769A (es) * | 2007-02-16 | 2009-08-25 | Wyeth Corp | Formulaciones de proteina que contienen sorbitol. |
US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
KR20100016661A (ko) * | 2007-04-18 | 2010-02-12 | 얀센 알츠하이머 이뮤노테라피 | 대뇌 아밀로이드 혈관병증의 예방 및 치료 |
EP2182983B1 (de) | 2007-07-27 | 2014-05-21 | Janssen Alzheimer Immunotherapy | Behandlung von amyloidogenen erkrankungen mittels humanisierter anti-abeta antikörper |
JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US8921315B1 (en) | 2008-04-24 | 2014-12-30 | Neumedicines, Inc. | Method of increasing survival of a human subject having exposure to an acute exposure to non-therapeutic whole body ionization by administering a therapeutically effective dose of IL-12 |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
DK2571516T3 (en) | 2010-05-18 | 2018-02-05 | Neumedicines Inc | IL-12 FORMULATIONS FOR STIMULATING HEMOPOIES |
KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
EP2718456B1 (de) | 2011-06-13 | 2019-04-24 | Neumedicines, Inc. | Linderung von hautverletzungen mittels il-12 |
EP2736530B1 (de) | 2011-07-27 | 2018-06-06 | Neumedicines, Inc | Verwendung von il-12 zur erzeugung von endogenem erythropoetin |
ES2937409T3 (es) | 2011-10-28 | 2023-03-28 | Prothena Biosciences Ltd | Anticuerpos humanizados que reconocen la alfa-sinucleína |
US9636381B2 (en) | 2012-01-18 | 2017-05-02 | Neumedicines, Inc. | Methods for radiation protection by administering IL-12 |
EP2807188B1 (de) | 2012-01-27 | 2019-09-11 | Prothena Biosciences Limited | Alpha-synuclein erkennende humanisierte antikörper |
UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
CN111050750A (zh) | 2017-08-24 | 2020-04-21 | 诺沃挪第克公司 | Glp-1组合物及其用途 |
SG11202103192RA (en) * | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
EP4106727A1 (de) | 2020-02-18 | 2022-12-28 | Novo Nordisk A/S | Pharmazeutische formulierungen |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3262575D1 (en) * | 1981-12-23 | 1985-04-18 | Schering Corp | Stabilised interferon formulations and their preparation |
JPS60243028A (ja) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | インタ−フエロンの可溶化方法 |
GR871067B (en) * | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
US5215743A (en) * | 1988-04-13 | 1993-06-01 | Maninder Singh | Tumor necrosis factor formulations |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
JP2893653B2 (ja) * | 1988-11-10 | 1999-05-24 | ジェネティックス・インスティテュート・インコーポレイテッド | ナチュラルキラー細胞刺激因子 |
US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
EP0433827B1 (de) * | 1989-12-22 | 1998-03-04 | F. Hoffmann-La Roche Ag | Zytotoxischer Lymphozyten-Reifefaktor |
IT1254359B (it) * | 1992-05-11 | 1995-09-14 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti il-6 |
DE4242919A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF |
US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
JPH06247870A (ja) * | 1993-02-23 | 1994-09-06 | Ajinomoto Co Inc | インターロイキン−6を含有する医薬製剤 |
DE4315127A1 (de) * | 1993-05-07 | 1994-11-10 | Behringwerke Ag | Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12 |
CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
US5573764A (en) * | 1994-01-21 | 1996-11-12 | Genetics Institute, Inc. | Use of interleukin-12 to prevent graft versus host disease |
-
1996
- 1996-02-02 EP EP96905322A patent/EP0820299B1/de not_active Expired - Lifetime
- 1996-02-02 WO PCT/US1996/001382 patent/WO1996024369A1/en active IP Right Grant
- 1996-02-02 AU AU49119/96A patent/AU695129B2/en not_active Ceased
- 1996-02-02 JP JP08524328A patent/JP2000510813A/ja active Pending
- 1996-02-02 AT AT96905322T patent/ATE216590T1/de active
- 1996-02-02 DE DE69620877T patent/DE69620877T2/de not_active Expired - Fee Related
-
1997
- 1997-01-14 US US08/783,523 patent/US5744132A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU695129B2 (en) | 1998-08-06 |
JP2000510813A (ja) | 2000-08-22 |
US5744132A (en) | 1998-04-28 |
DE69620877T2 (de) | 2002-12-12 |
MX9705959A (es) | 1997-11-29 |
EP0820299A1 (de) | 1998-01-28 |
WO1996024369A1 (en) | 1996-08-15 |
AU4911996A (en) | 1996-08-27 |
DE69620877D1 (de) | 2002-05-29 |
EP0820299B1 (de) | 2002-04-24 |
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