MXPA03010649A - Administracion pulmonar de insulina modificada quimicamente. - Google Patents

Administracion pulmonar de insulina modificada quimicamente.

Info

Publication number
MXPA03010649A
MXPA03010649A MXPA03010649A MXPA03010649A MXPA03010649A MX PA03010649 A MXPA03010649 A MX PA03010649A MX PA03010649 A MXPA03010649 A MX PA03010649A MX PA03010649 A MXPA03010649 A MX PA03010649A MX PA03010649 A MXPA03010649 A MX PA03010649A
Authority
MX
Mexico
Prior art keywords
chemically modified
pulmonary administration
insulin
modified insulin
derivatives
Prior art date
Application number
MXPA03010649A
Other languages
English (en)
Inventor
Milton Harris J
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MXPA03010649A publication Critical patent/MXPA03010649A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion proporciona derivados de insulina modificados con un polimero hidrofilico, activo. Los derivados de insulina de la invencion son, en un aspecto, adecuados para administrarse al pulmon y exhiben propiedades farmacocineticas y/o farmacodinamicas que se mejoran significativamente con respecto a la insulina natural.
MXPA03010649A 2001-05-21 2002-05-21 Administracion pulmonar de insulina modificada quimicamente. MXPA03010649A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29242301P 2001-05-21 2001-05-21
PCT/US2002/016464 WO2002094200A2 (en) 2001-05-21 2002-05-21 Pulmonary administration of chemically modified insulin

Publications (1)

Publication Number Publication Date
MXPA03010649A true MXPA03010649A (es) 2005-10-05

Family

ID=23124608

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010649A MXPA03010649A (es) 2001-05-21 2002-05-21 Administracion pulmonar de insulina modificada quimicamente.

Country Status (35)

Country Link
US (3) US6838076B2 (es)
EP (1) EP1395294A4 (es)
JP (1) JP2004535401A (es)
KR (1) KR20030097876A (es)
CN (2) CN101045166A (es)
AP (1) AP1763A (es)
AR (1) AR033903A1 (es)
AU (1) AU2002303869B2 (es)
BG (1) BG108494A (es)
BR (1) BR0209896A (es)
CA (1) CA2447236A1 (es)
CO (1) CO5540371A2 (es)
CZ (1) CZ20033182A3 (es)
EA (1) EA007408B1 (es)
EC (1) ECSP034855A (es)
GE (1) GEP20063917B (es)
HR (1) HRP20030949A2 (es)
HU (1) HUP0400442A2 (es)
IL (2) IL158862A0 (es)
IS (1) IS7043A (es)
LT (1) LT5153B (es)
LV (1) LV13197B (es)
MA (1) MA26185A1 (es)
MX (1) MXPA03010649A (es)
MY (1) MY137181A (es)
NO (1) NO20035157D0 (es)
NZ (1) NZ529572A (es)
OA (1) OA13136A (es)
PL (1) PL366911A1 (es)
SK (1) SK15532003A3 (es)
TN (1) TNSN03116A1 (es)
TR (1) TR200400295T2 (es)
WO (1) WO2002094200A2 (es)
YU (1) YU98503A (es)
ZA (1) ZA200309085B (es)

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