MX2007008379A - Metodos y composiciones para minimizar la acumulacion de insulina inhlable en los pulmones. - Google Patents

Metodos y composiciones para minimizar la acumulacion de insulina inhlable en los pulmones.

Info

Publication number
MX2007008379A
MX2007008379A MX2007008379A MX2007008379A MX2007008379A MX 2007008379 A MX2007008379 A MX 2007008379A MX 2007008379 A MX2007008379 A MX 2007008379A MX 2007008379 A MX2007008379 A MX 2007008379A MX 2007008379 A MX2007008379 A MX 2007008379A
Authority
MX
Mexico
Prior art keywords
accrual
lungs
minimizing
methods
compositions
Prior art date
Application number
MX2007008379A
Other languages
English (en)
Inventor
Cohava Gelber
Anders Boss
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX2007008379A publication Critical patent/MX2007008379A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Se proveen composiciones de insulina inhalable que se eliminan rapidamente de los pulmones de los pacientes. Adicionalmente se describen metodo para minimizar la acumulacion de insulina despues de la administracion de una composicion de insulina inhalada.
MX2007008379A 2005-01-10 2006-01-10 Metodos y composiciones para minimizar la acumulacion de insulina inhlable en los pulmones. MX2007008379A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64305405P 2005-01-10 2005-01-10
PCT/US2006/000910 WO2006086107A2 (en) 2005-01-10 2006-01-10 Methods and compositions for minimizing accrual of inhalable insulin in the lungs

Publications (1)

Publication Number Publication Date
MX2007008379A true MX2007008379A (es) 2008-02-19

Family

ID=36793549

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008379A MX2007008379A (es) 2005-01-10 2006-01-10 Metodos y composiciones para minimizar la acumulacion de insulina inhlable en los pulmones.

Country Status (7)

Country Link
US (1) US20060153778A1 (es)
EP (1) EP1858486A2 (es)
JP (1) JP2008526893A (es)
AU (1) AU2006213084A1 (es)
CA (1) CA2592776A1 (es)
MX (1) MX2007008379A (es)
WO (1) WO2006086107A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU779986B2 (en) 1999-06-29 2005-02-24 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US9006175B2 (en) * 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US9078866B2 (en) * 2003-08-01 2015-07-14 Mannkind Corporation Method for treating hyperglycemia with GLP-1
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
AU2014271222B2 (en) * 2005-09-14 2016-04-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
MX2010004510A (es) * 2007-10-24 2010-07-02 Mannkind Corp Metodo para prevenir los efectos nocivos de peptido 1 tipo glucagon (glp-1).
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
US20190262557A1 (en) * 2010-03-04 2019-08-29 Mannkind Corporation Dry powder drug delivery system
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) * 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US11110151B2 (en) * 2008-08-11 2021-09-07 Mannkind Corporation Composition and method for reducing hypoglycemia events in diabetes treatment
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
AU2014200960B2 (en) * 2009-03-04 2016-02-11 Mannkind Corporation An improved dry powder drug delivery system
CA2791847C (en) * 2009-03-04 2017-05-02 Mannkind Corporation An improved dry powder drug delivery system
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
MY172858A (en) * 2009-06-12 2019-12-12 Mannkind Corp Diketopiperazine microparticles with defined isomer contents
EP2440184B1 (en) * 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

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US2000301A (en) * 1932-04-02 1935-05-07 Norman Confections Inc Progressive container
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
AU779986B2 (en) * 1999-06-29 2005-02-24 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
JP2007517892A (ja) * 2004-01-12 2007-07-05 マンカインド コーポレイション ２型糖尿病における血清プロインスリンレベルを低下させる方法

Also Published As

Publication number Publication date
CA2592776A1 (en) 2006-08-17
WO2006086107A2 (en) 2006-08-17
WO2006086107A3 (en) 2006-11-23
JP2008526893A (ja) 2008-07-24
EP1858486A2 (en) 2007-11-28
AU2006213084A1 (en) 2006-08-17
US20060153778A1 (en) 2006-07-13

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