WO2005079867A3 - Alpha-emitting hydroxyapatite particles - Google Patents

Alpha-emitting hydroxyapatite particles Download PDF

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Publication number
WO2005079867A3
WO2005079867A3 PCT/GB2005/000616 GB2005000616W WO2005079867A3 WO 2005079867 A3 WO2005079867 A3 WO 2005079867A3 GB 2005000616 W GB2005000616 W GB 2005000616W WO 2005079867 A3 WO2005079867 A3 WO 2005079867A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
hydroxyapatite particles
emitting
emitting radionuclide
emitting hydroxyapatite
Prior art date
Application number
PCT/GB2005/000616
Other languages
French (fr)
Other versions
WO2005079867A2 (en
Inventor
Gro Salberg
Roy Larsen
Original Assignee
Algeta As
Goddard Chris
Gro Salberg
Roy Larsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0403856.8A external-priority patent/GB0403856D0/en
Priority to US10/588,839 priority Critical patent/US8142758B2/en
Priority to EA200601524A priority patent/EA020542B1/en
Priority to KR1020107009801A priority patent/KR101165518B1/en
Priority to AU2005215234A priority patent/AU2005215234B2/en
Priority to JP2006553676A priority patent/JP5214884B2/en
Priority to DK05708405.5T priority patent/DK1735013T3/en
Priority to EP05708405A priority patent/EP1735013B1/en
Priority to NZ549080A priority patent/NZ549080A/en
Priority to CN2005800124785A priority patent/CN1972720B/en
Priority to AT05708405T priority patent/ATE544492T1/en
Priority to CA2555435A priority patent/CA2555435C/en
Priority to BRPI0507824-5A priority patent/BRPI0507824A/en
Priority to PL05708405T priority patent/PL1735013T3/en
Priority to ES05708405T priority patent/ES2382041T3/en
Application filed by Algeta As, Goddard Chris, Gro Salberg, Roy Larsen filed Critical Algeta As
Publication of WO2005079867A2 publication Critical patent/WO2005079867A2/en
Publication of WO2005079867A3 publication Critical patent/WO2005079867A3/en
Priority to IL177354A priority patent/IL177354A/en
Priority to NO20064232A priority patent/NO20064232L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides Hydroxyapatite (HA) incorporating an alpha-emitting radionuclide or an in vivo generator for an alpha-emitting radionuclide. The invention further provides methods for the formation of such HA, pharmaceutical compositions comprising the HA and methods of medical treatment of cancerous or non­cancerous disease including administering the HA or compositions thereof.
PCT/GB2005/000616 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles WO2005079867A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EA200601524A EA020542B1 (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
AT05708405T ATE544492T1 (en) 2004-02-20 2005-02-18 ALPHA AND BETA EMITTING HYDROXYAPATITE PARTICLES
CN2005800124785A CN1972720B (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
AU2005215234A AU2005215234B2 (en) 2004-02-20 2005-02-18 Alpha-emitting Hydroxyapatite particles
JP2006553676A JP5214884B2 (en) 2004-02-20 2005-02-18 Alpha radioactive hydroxyapatite particles
DK05708405.5T DK1735013T3 (en) 2004-02-20 2005-02-18 Alpha and beta emitting hydroxyapatite particles
EP05708405A EP1735013B1 (en) 2004-02-20 2005-02-18 Alpha- and beta-emitting hydroxyapatite particles
NZ549080A NZ549080A (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
KR1020107009801A KR101165518B1 (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
US10/588,839 US8142758B2 (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
BRPI0507824-5A BRPI0507824A (en) 2004-02-20 2005-02-18 hydroxyapatite, process for the preparation of a radionuclide-labeled hydroxyapatite particulate, pharmaceutical composition, use of hydroxyapatite and an alpha-emitting radionuclide or a beta-emitting radionuclide, device, and, method of radiochemical treatment of a human or human individual non-human animal needing the same
CA2555435A CA2555435C (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles
PL05708405T PL1735013T3 (en) 2004-02-20 2005-02-18 Alpha- and beta-emitting hydroxyapatite particles
ES05708405T ES2382041T3 (en) 2004-02-20 2005-02-18 Alpha and beta emission hydroxyapatite particles
IL177354A IL177354A (en) 2004-02-20 2006-08-08 Alpha-emitting hydroxyapatite particles
NO20064232A NO20064232L (en) 2004-02-20 2006-09-19 Alpha emitting hydroxyapatite particles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0403856.8 2004-02-20
GBGB0403856.8A GB0403856D0 (en) 2004-02-20 2004-02-20 Composition
US54687804P 2004-02-23 2004-02-23
US60/546,878 2004-02-23

Publications (2)

Publication Number Publication Date
WO2005079867A2 WO2005079867A2 (en) 2005-09-01
WO2005079867A3 true WO2005079867A3 (en) 2006-03-16

Family

ID=34889141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/000616 WO2005079867A2 (en) 2004-02-20 2005-02-18 Alpha-emitting hydroxyapatite particles

Country Status (8)

Country Link
US (1) US8142758B2 (en)
EP (1) EP1735013B1 (en)
AU (1) AU2005215234B2 (en)
BR (1) BRPI0507824A (en)
CA (1) CA2555435C (en)
EA (1) EA020542B1 (en)
PL (1) PL1735013T3 (en)
WO (1) WO2005079867A2 (en)

Families Citing this family (21)

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WO2007008232A2 (en) * 2004-09-03 2007-01-18 Board Of Regents, The University Of Texas System Locoregional internal radionuclide ablation of abnormal tissues.
US20070009436A1 (en) * 2005-07-08 2007-01-11 Rondinone Adam J Radionuclide nanoparticles encased by inorganic shell having vector biomolecules attached thereto
CN101125208B (en) * 2007-08-03 2011-08-31 华中科技大学 Preparation method of apatite developing agent
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201009455D0 (en) 2010-06-04 2010-07-21 King S College London Nanoparticles and their uses in molecular imaging
US9849200B2 (en) 2010-09-16 2017-12-26 Mo-Sci Corporation Strontium phosphate microparticle for radiological imaging and therapy
US8865123B1 (en) * 2010-09-16 2014-10-21 Mo-Sci Corporation Strontium phosphate microparticle for radiological imaging and therapy
US9399708B2 (en) 2012-04-12 2016-07-26 Howard University Polylactide and calcium phosphate compositions and methods of making the same
US8993978B2 (en) 2012-05-04 2015-03-31 Honeywell International Inc. Method for assessing an alpha particle emission potential of A metallic material
FR2990956B1 (en) * 2012-05-24 2014-07-04 Areva Med Sas PROCESS AND APPARATUS FOR THE PRODUCTION OF LEAD 212 FOR MEDICAL USE
BR112015010675A8 (en) 2012-11-09 2019-10-01 Colgate Palmolive Co oral hygiene composition comprising block copolymer and method for protecting tooth enamel from acid erosion ”
EP3077002B1 (en) 2013-12-03 2020-04-22 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
EP3077003A1 (en) 2013-12-03 2016-10-12 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
CN103706385B (en) * 2014-01-23 2015-09-09 河南理工大学 Fe 3o 4/ SiO 2/ molecular engram hydroxyapatite nuclear shell structure nano composite photo-catalyst and preparation method thereof
US10548996B2 (en) * 2014-03-28 2020-02-04 Washington University Hydrogels for localized radiotherapy
KR102630614B1 (en) * 2015-02-26 2024-01-26 사이언콘스 에이에스 Radiopharmaceutical solutions with beneficial properties
EP3061464B1 (en) * 2015-02-26 2017-10-25 Sciencons AS Radiopharmaceutical solutions with advantageous properties
US9433690B1 (en) 2015-02-26 2016-09-06 Sciencons AS Radiopharmaceutical solutions with advantageous properties
DK3111959T3 (en) * 2015-07-03 2018-01-02 Oncoinvent As Radiopharmaceutical particles and suspensions
US20170065731A1 (en) * 2015-09-06 2017-03-09 Medical Theranostics Inc. Method, Apparatus, and System for Radiation Therapy
CN111115609A (en) * 2019-12-23 2020-05-08 华中科技大学鄂州工业技术研究院 Sr-Fe co-doped HAP nano-particles and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001304A1 (en) * 1995-06-29 1997-01-16 Mallinckrodt Medical, Inc. Radiolabeled apatite particles containing a paramagnetic ion
WO2001028587A2 (en) * 1999-10-18 2001-04-26 Ferx Incorporated Magnetic targeted carrier
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes

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US5085848A (en) 1989-05-30 1992-02-04 The United States Of America As Represented By The United States Department Of Energy Method of treating inflammatory diseases using a radiolabeled ferric hydroxide calloid
US4970062A (en) * 1989-05-30 1990-11-13 The United States Of America As Represented By The United States Department Of Energy Colloid labelled with radionuclide and method
US5137709A (en) * 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
US5344640A (en) * 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
WO2000029034A1 (en) * 1998-11-12 2000-05-25 Nycomed Amersham Plc Products and methods
NO310544B1 (en) 1999-01-04 2001-07-23 Algeta As Preparation and use of radium-223 for the preparation of preparations and kits for the treatment of calcified tissue for palliation, bone cancer therapy and / or bone surface treatment
NO314537B1 (en) 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Receptor binding conjugates
NO313180B1 (en) 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Visiting alpha particles emitting radiopharmaceuticals
GB0213261D0 (en) 2002-06-10 2002-07-17 Anticancer Therapeutic Inv Sa Method
GB0308731D0 (en) 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001304A1 (en) * 1995-06-29 1997-01-16 Mallinckrodt Medical, Inc. Radiolabeled apatite particles containing a paramagnetic ion
WO2001028587A2 (en) * 1999-10-18 2001-04-26 Ferx Incorporated Magnetic targeted carrier
WO2001060417A2 (en) * 2000-02-21 2001-08-23 Anticancer Therapeutic Inventions As Radioactive therapeutic liposomes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
UNNI P. R. ET AL: "Preparation and bioevaluation of 166Ho labelled hydroxyapatite (HA) particles for radiosynovectomy", NUCLEAR MEDICINE AND BIOLOGY, vol. 29, 2002, pages 199 - 209, XP004334818 *
VERGOTE I. ET AL: "Therapeutic efficacy of the a-emitter 211At bound on microspheres compared with 90Y and 32P colloids in a murine intraperitoneal tumor model", GYNECOLOGIC ONCOLOGY, vol. 47, 1992, pages 366 - 372, XP008057114 *

Also Published As

Publication number Publication date
AU2005215234B2 (en) 2009-02-19
EA020542B1 (en) 2014-12-30
CA2555435C (en) 2011-07-12
US20080226547A1 (en) 2008-09-18
BRPI0507824A (en) 2007-07-10
US8142758B2 (en) 2012-03-27
WO2005079867A2 (en) 2005-09-01
EP1735013A2 (en) 2006-12-27
AU2005215234A1 (en) 2005-09-01
EA200601524A1 (en) 2007-02-27
EP1735013B1 (en) 2012-02-08
CA2555435A1 (en) 2005-09-01
PL1735013T3 (en) 2012-07-31

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