YU98503A - Pulmonarno ordiniranje hemijski modifikovanog insulina - Google Patents

Pulmonarno ordiniranje hemijski modifikovanog insulina

Info

Publication number
YU98503A
YU98503A YU98503A YUP98503A YU98503A YU 98503 A YU98503 A YU 98503A YU 98503 A YU98503 A YU 98503A YU P98503 A YUP98503 A YU P98503A YU 98503 A YU98503 A YU 98503A
Authority
YU
Yugoslavia
Prior art keywords
chemically modified
pulmonary administration
insulin
modified insulin
derivatives
Prior art date
Application number
YU98503A
Other languages
English (en)
Inventor
John S. Patton
Mei-Chang Kuo
J.Milton Harris
Chester Leach
Kimberly Perkins
Blaine Bueche
Original Assignee
Nektar Therapeutics
Nektar Therapeutics Al Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics, Nektar Therapeutics Al Corporation filed Critical Nektar Therapeutics
Publication of YU98503A publication Critical patent/YU98503A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Ovaj pronalazak daje aktivne derivate insulina modifikovane sa hidrofilnim polimerom. Derivati insulina iz ovog pronalaska su, u jednom aspektu, pogodni za oslobađanje u plućima i pokazuju farmakokinetička i/ili farmakodinamička svojstva koja su signifikantno poboljšana u odnosu na nativni insulin.[The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are significantly improved over native insulin.
YU98503A 2001-05-21 2002-05-21 Pulmonarno ordiniranje hemijski modifikovanog insulina YU98503A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29242301P 2001-05-21 2001-05-21

Publications (1)

Publication Number Publication Date
YU98503A true YU98503A (sh) 2006-05-25

Family

ID=23124608

Family Applications (1)

Application Number Title Priority Date Filing Date
YU98503A YU98503A (sh) 2001-05-21 2002-05-21 Pulmonarno ordiniranje hemijski modifikovanog insulina

Country Status (35)

Country Link
US (3) US6838076B2 (sh)
EP (1) EP1395294A4 (sh)
JP (1) JP2004535401A (sh)
KR (1) KR20030097876A (sh)
CN (2) CN1314445C (sh)
AP (1) AP1763A (sh)
AR (1) AR033903A1 (sh)
AU (1) AU2002303869B2 (sh)
BG (1) BG108494A (sh)
BR (1) BR0209896A (sh)
CA (1) CA2447236A1 (sh)
CO (1) CO5540371A2 (sh)
CZ (1) CZ20033182A3 (sh)
EA (1) EA007408B1 (sh)
EC (1) ECSP034855A (sh)
GE (1) GEP20063917B (sh)
HR (1) HRP20030949A2 (sh)
HU (1) HUP0400442A2 (sh)
IL (2) IL158862A0 (sh)
IS (1) IS7043A (sh)
LT (1) LT5153B (sh)
LV (1) LV13197B (sh)
MA (1) MA26185A1 (sh)
MX (1) MXPA03010649A (sh)
MY (1) MY137181A (sh)
NO (1) NO20035157D0 (sh)
NZ (1) NZ529572A (sh)
OA (1) OA13136A (sh)
PL (1) PL366911A1 (sh)
SK (1) SK15532003A3 (sh)
TN (1) TNSN03116A1 (sh)
TR (1) TR200400295T2 (sh)
WO (1) WO2002094200A2 (sh)
YU (1) YU98503A (sh)
ZA (1) ZA200309085B (sh)

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