CO5540371A2 - Administracion pulmonar de insulina quimicamente modificada - Google Patents

Administracion pulmonar de insulina quimicamente modificada

Info

Publication number
CO5540371A2
CO5540371A2 CO03102566A CO03102566A CO5540371A2 CO 5540371 A2 CO5540371 A2 CO 5540371A2 CO 03102566 A CO03102566 A CO 03102566A CO 03102566 A CO03102566 A CO 03102566A CO 5540371 A2 CO5540371 A2 CO 5540371A2
Authority
CO
Colombia
Prior art keywords
composition
pulmonary administration
chemically modified
hydrophilic polymer
modified insulin
Prior art date
Application number
CO03102566A
Other languages
English (en)
Inventor
John S Patton
Kuo Mei-Chang
J Milton Harris
Chester Leach
Perkins Kimberly
Bueche Blaine
Original Assignee
Nektar Therapeutics
Nektar Therapeutics Al Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics, Nektar Therapeutics Al Corp filed Critical Nektar Therapeutics
Publication of CO5540371A2 publication Critical patent/CO5540371A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

1.- Una composición de insulina para administración pulmonar, dicha composición comprende un conjugado de insulina acoplado covalentemente a uno o más moléculas de un polímero hidrofílico de ocurrencia no natural.2.- La composición de insulina de la reivindicación 1, en donde dicho conjugado está ausente de parte lipofílica.3.- La composición de insulina de la reivindicación 1, en donde dicho polímero hidrofílico de ocurrencia no natural es un polialquilen glicol. 4.- La composición de la reivindicación 1, en donde dicho polímero hidrofílico de ocurrencia no natural es un polietilen glicol.5.- La composición de la reivindicación 2, en donde dicho polímero hidrofílico de ocurrencia no natural es polietilen glicol.
CO03102566A 2001-05-21 2003-11-20 Administracion pulmonar de insulina quimicamente modificada CO5540371A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29242301P 2001-05-21 2001-05-21

Publications (1)

Publication Number Publication Date
CO5540371A2 true CO5540371A2 (es) 2005-07-29

Family

ID=23124608

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03102566A CO5540371A2 (es) 2001-05-21 2003-11-20 Administracion pulmonar de insulina quimicamente modificada

Country Status (35)

Country Link
US (3) US6838076B2 (es)
EP (1) EP1395294A4 (es)
JP (1) JP2004535401A (es)
KR (1) KR20030097876A (es)
CN (2) CN101045166A (es)
AP (1) AP1763A (es)
AR (1) AR033903A1 (es)
AU (1) AU2002303869B2 (es)
BG (1) BG108494A (es)
BR (1) BR0209896A (es)
CA (1) CA2447236A1 (es)
CO (1) CO5540371A2 (es)
CZ (1) CZ20033182A3 (es)
EA (1) EA007408B1 (es)
EC (1) ECSP034855A (es)
GE (1) GEP20063917B (es)
HR (1) HRP20030949A2 (es)
HU (1) HUP0400442A2 (es)
IL (2) IL158862A0 (es)
IS (1) IS7043A (es)
LT (1) LT5153B (es)
LV (1) LV13197B (es)
MA (1) MA26185A1 (es)
MX (1) MXPA03010649A (es)
MY (1) MY137181A (es)
NO (1) NO20035157D0 (es)
NZ (1) NZ529572A (es)
OA (1) OA13136A (es)
PL (1) PL366911A1 (es)
SK (1) SK15532003A3 (es)
TN (1) TNSN03116A1 (es)
TR (1) TR200400295T2 (es)
WO (1) WO2002094200A2 (es)
YU (1) YU98503A (es)
ZA (1) ZA200309085B (es)

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