ATE477020T1 - Prevention und verringerung von ischemia - Google Patents

Prevention und verringerung von ischemia

Info

Publication number
ATE477020T1
ATE477020T1 AT03757339T AT03757339T ATE477020T1 AT E477020 T1 ATE477020 T1 AT E477020T1 AT 03757339 T AT03757339 T AT 03757339T AT 03757339 T AT03757339 T AT 03757339T AT E477020 T1 ATE477020 T1 AT E477020T1
Authority
AT
Austria
Prior art keywords
phe
cys
glu
ala
gly
Prior art date
Application number
AT03757339T
Other languages
English (en)
Inventor
Robert Ladner
Arthur Ley
Shirish Hirani
Anthony Williams
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of ATE477020T1 publication Critical patent/ATE477020T1/de

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6445Kallikreins (3.4.21.34; 3.4.21.35)
AT03757339T 2002-06-07 2003-06-06 Prevention und verringerung von ischemia ATE477020T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38723902P 2002-06-07 2002-06-07
US40700302P 2002-08-28 2002-08-28
PCT/US2003/017665 WO2003103475A2 (en) 2002-06-07 2003-06-06 Prevention and reduction of blood loss

Publications (1)

Publication Number Publication Date
ATE477020T1 true ATE477020T1 (de) 2010-08-15

Family

ID=29739936

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03757339T ATE477020T1 (de) 2002-06-07 2003-06-06 Prevention und verringerung von ischemia
AT07023364T ATE528014T1 (de) 2002-06-07 2003-06-06 Polypeptid mit modifizierten kunitz domains

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07023364T ATE528014T1 (de) 2002-06-07 2003-06-06 Polypeptid mit modifizierten kunitz domains

Country Status (13)

Country Link
US (13) US7064107B2 (de)
EP (4) EP2298278B1 (de)
JP (3) JP2005534647A (de)
AT (2) ATE477020T1 (de)
AU (3) AU2003243394B2 (de)
CA (1) CA2488558C (de)
CY (1) CY1112228T1 (de)
DE (1) DE60333758D1 (de)
DK (4) DK1531791T3 (de)
ES (4) ES2372978T3 (de)
HK (3) HK1119955A1 (de)
PT (4) PT1531791E (de)
WO (1) WO2003103475A2 (de)

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US20080064637A1 (en) 2008-03-13
US20110086801A1 (en) 2011-04-14
US7811991B2 (en) 2010-10-12
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US20140349940A1 (en) 2014-11-27
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PT2298278E (pt) 2016-02-25
PT1531791E (pt) 2010-12-16
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US20160361395A1 (en) 2016-12-15
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ES2372978T3 (es) 2012-01-30
US20190247477A1 (en) 2019-08-15
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CA2488558C (en) 2013-08-20
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US11344610B2 (en) 2022-05-31
US20080131426A1 (en) 2008-06-05
AU2003243394A1 (en) 2003-12-22
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