DE60333758D1 - Prevention und Verringerung von Ischemia - Google Patents
Prevention und Verringerung von IschemiaInfo
- Publication number
- DE60333758D1 DE60333758D1 DE60333758T DE60333758T DE60333758D1 DE 60333758 D1 DE60333758 D1 DE 60333758D1 DE 60333758 T DE60333758 T DE 60333758T DE 60333758 T DE60333758 T DE 60333758T DE 60333758 D1 DE60333758 D1 DE 60333758D1
- Authority
- DE
- Germany
- Prior art keywords
- phe
- cys
- glu
- ala
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38723902P | 2002-06-07 | 2002-06-07 | |
US40700302P | 2002-08-28 | 2002-08-28 | |
PCT/US2003/017665 WO2003103475A2 (en) | 2002-06-07 | 2003-06-06 | Prevention and reduction of blood loss |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60333758D1 true DE60333758D1 (de) | 2010-09-23 |
Family
ID=29739936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60333758T Expired - Lifetime DE60333758D1 (de) | 2002-06-07 | 2003-06-06 | Prevention und Verringerung von Ischemia |
Country Status (13)
Country | Link |
---|---|
US (13) | US7064107B2 (de) |
EP (4) | EP2311432B1 (de) |
JP (3) | JP2005534647A (de) |
AT (2) | ATE528014T1 (de) |
AU (3) | AU2003243394B2 (de) |
CA (1) | CA2488558C (de) |
CY (1) | CY1112228T1 (de) |
DE (1) | DE60333758D1 (de) |
DK (4) | DK1531791T3 (de) |
ES (4) | ES2372978T3 (de) |
HK (3) | HK1119955A1 (de) |
PT (4) | PT1531791E (de) |
WO (1) | WO2003103475A2 (de) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US6801634B2 (en) | 2000-07-31 | 2004-10-05 | Harman International Industries, Inc. | Loudspeaker coil suspension system |
US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
DK1531791T3 (da) | 2002-06-07 | 2010-11-01 | Dyax Corp | Forebyggelse og begrænsning af iskæmi |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
PT2386310T (pt) * | 2002-08-28 | 2019-02-05 | Dyax Corp | Métodos para preservar órgãos e tecidos |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
CA2536873C (en) * | 2003-08-29 | 2019-09-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
ATE489062T1 (de) * | 2003-09-12 | 2010-12-15 | Z Medica Corp | Teilweise hydriertes hämostatisches mittel |
US20060177971A1 (en) * | 2004-01-13 | 2006-08-10 | Jsr Corporation | Anisotropically conductive connector, production process thereof and application product thereof |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
RU2514878C2 (ru) | 2004-12-23 | 2014-05-10 | Ксл Бехринг Гмбх | Предотвращение образования и/или стабилизации тромбов |
US20060178609A1 (en) | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
CA2597940A1 (en) | 2005-02-15 | 2006-08-24 | Virginia Commonwealth University | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
US9829494B2 (en) | 2005-12-01 | 2017-11-28 | Adrenomed Ag | Methods of treatment using ADM antibodies |
WO2007106746A2 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
DK1854477T3 (en) * | 2006-03-16 | 2016-11-28 | Dyax Corp | Peptide inhibitors of plasma kallikrein for use in the treatment of eye disorders |
DK2374472T3 (en) | 2006-03-16 | 2018-08-13 | Dyax Corp | Compositions and Methods for the Treatment of Eye Disorders |
US8938898B2 (en) * | 2006-04-27 | 2015-01-27 | Z-Medica, Llc | Devices for the identification of medical products |
US8202532B2 (en) * | 2006-05-26 | 2012-06-19 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US7968114B2 (en) | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US20080085300A1 (en) * | 2006-10-06 | 2008-04-10 | Z-Medica Corporation | Hemostatic compositions and method of manufacture |
US9345457B2 (en) | 2006-12-13 | 2016-05-24 | Devicor Medical Products, Inc. | Presentation of biopsy sample by biopsy device |
AU2008289005A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
CA2695012A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
US20090162406A1 (en) * | 2007-09-05 | 2009-06-25 | Z-Medica Corporation | Wound healing with zeolite-based hemostatic devices |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
LT3459564T (lt) | 2010-01-06 | 2022-03-10 | Takeda Pharmaceutical Company Limited | Plazmos kalikreiną surišantys baltymai |
EP2347778A1 (de) | 2010-01-25 | 2011-07-27 | ECP Entwicklungsgesellschaft mbH | Fluidpumpe mit einem radial komprimierbaren Rotor |
US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
IL310186A (en) | 2011-01-06 | 2024-03-01 | Takeda Pharmaceuticals Co | KALLIKREIN PLASMA BINDING PROTEINS |
WO2012170945A2 (en) | 2011-06-10 | 2012-12-13 | Isis Pharmaceuticals, Inc. | Methods for modulating kallikrein (klkb1) expression |
WO2013003808A1 (en) | 2011-06-29 | 2013-01-03 | Isis Pharmaceuticals, Inc. | Methods for modulating kallikrein (klkb1) expression |
AU2012338731B2 (en) | 2011-11-16 | 2017-07-06 | Adrenomed Ag | Anti-adrenomedullin (ADM) antibody or anti-ADM antibody fragment or anti-ADM non-Ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
SG11201402351WA (en) | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy |
JP6321544B2 (ja) | 2011-11-16 | 2018-05-09 | アドレノメト アクチェンゲゼルシャフト | 慢性若しくは急性疾患又は急性病態に罹患している患者の死亡リスクを低減するための抗アドレノメデュリン(ADM)抗体、抗ADM抗体フラグメント又は抗ADM非Ig足場 |
CN104067130B (zh) | 2011-11-16 | 2017-02-22 | 斯弗因高泰克有限公司 | 肾上腺髓质素测定与用于确定成熟肾上腺髓质素的方法 |
WO2013072514A1 (en) | 2011-11-16 | 2013-05-23 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
PT2780370T (pt) | 2011-11-16 | 2019-10-30 | Adrenomed Ag | Anticorpo anti-adrenomedulina (adm) ou fragmento anticorpo anti-adm ou estrutura de anticorpo anti-adm não ig para utilização na terapia de uma doença aguda ou condição aguda de um paciente para estabilizar a circulação |
CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
CA3183404A1 (en) | 2012-06-22 | 2013-12-27 | Teleflex Life Sciences Limited | Hemostatic devices |
RU2679913C2 (ru) | 2012-10-02 | 2019-02-14 | Сфинготек Гмбх | Способ диагностики или мониторинга почечной функции или диагностики почечной дисфункции |
CN107991501A (zh) | 2013-01-08 | 2018-05-04 | 斯弗因高泰克有限公司 | 生长激素的禁食水平作为心血管风险的预测标志物 |
ES2718347T3 (es) | 2013-01-20 | 2019-07-01 | Dyax Corp | Evaluación, ensayos y tratamiento de trastornos mediados por pKal |
RS57890B1 (sr) | 2013-01-20 | 2019-01-31 | Dyax Corp | Procena i tretman poremećaja posredovanih bradikininom |
SG11201507774YA (en) | 2013-03-20 | 2015-10-29 | Sphingotec Gmbh | Adrenomedullin to guide therapy of blood pressure decline |
KR102365486B1 (ko) | 2013-08-28 | 2022-02-18 | 아이오니스 파마수티컬즈, 인코포레이티드 | 프리칼리크레인 (pkk) 발현의 조절 |
KR20230054745A (ko) | 2013-10-21 | 2023-04-25 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
AU2014340449B2 (en) | 2013-10-21 | 2019-10-31 | Takeda Pharmaceutical Company Limited | Diagnosis and treatment of autoimmune diseases |
EA038532B1 (ru) | 2014-01-21 | 2021-09-10 | Такеда Фармасьютикал Компани Лимитед | Способ лечения наследственного ангионевротического отека (hae) |
AU2015235967B2 (en) | 2014-03-27 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Compositions and methods for treatment of diabetic macular edema |
DK3137091T3 (da) | 2014-05-01 | 2021-01-25 | Ionis Pharmaceuticals Inc | Konjugater af modificerede antisense-oligonukleotider og anvendelse deraf til modulation af pkk-ekspression |
EP3002589A1 (de) | 2014-10-01 | 2016-04-06 | sphingotec GmbH | Verfahren zur stratifizierung einer frau zur hormonersatztherapie |
IL305207A (en) | 2015-03-30 | 2023-10-01 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and their uses to prevent the outbreak of hereditary angioedema |
EP3286570A1 (de) | 2015-04-24 | 2018-02-28 | SphingoTec GmbH | Verfahren zur vorhersage des risikos für das auftreten einer chronischen nierenerkrankung |
KR20180093897A (ko) | 2015-10-19 | 2018-08-22 | 다이액스 코포레이션 | 절단된 고분자량 키니노겐의 검출을 위한 면역검정법 |
CO2018007151A2 (es) | 2015-12-11 | 2018-09-20 | Dyax Corp | Inhibidores de calicreína plasmática y usos de los mismos para tratar ataque de angioedema hereditario |
KR20230123520A (ko) | 2016-04-21 | 2023-08-23 | 4틴4 파마슈티컬스 게엠베하 | Dpp3을 결정하는 방법 및 치료 방법 |
MA45493A (fr) | 2016-06-27 | 2019-05-01 | Aicuris Anti Infective Cures Gmbh | Inhibiteurs d'entrée de hcmv. |
BR112019000199A2 (pt) | 2016-07-08 | 2019-04-16 | Sphingotec Gmbh | adrenomedulina para avaliar a congestão em um indivíduo com insuficiência cardíaca aguda |
BR112019005179A2 (pt) | 2016-09-16 | 2019-07-02 | Dyax Corp | método e kit para analisar uma amostra |
CA3036979A1 (en) | 2016-09-16 | 2018-03-22 | Dyax Corp. | Rna biomarkers for hereditary angioedema |
BR112019005167A2 (pt) | 2016-09-16 | 2019-07-02 | Dyax Corp | método e kit para analisar uma amostra |
EP3309550A1 (de) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Verfahren zum nachweis von apolipoprotein e4 |
EP3339324A1 (de) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm)-antikörper oder anti-adm antikörperfragment oder anti-adm-nicht-ig-gerüst zur verwendung in einer intervention und therapie von verstopfung bei einem darauf angewiesenen patienten |
US20200299372A1 (en) | 2016-12-16 | 2020-09-24 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in intervention and therapy of congestion in a patient in need thereof |
BR112019024966A2 (pt) | 2017-05-30 | 2020-06-23 | Sphingotec Gmbh | Método para diagnosticar ou monitorar a função renal ou diagnosticar a disfunção renal |
EP4159229A1 (de) | 2017-09-25 | 2023-04-05 | AdrenoMed AG | Anti-adrenomedullin (adm)-bindemittel zur verwendung in der therapie oder vorbeugung von krankheitssymptomen |
MX2020004072A (es) | 2017-10-18 | 2020-07-28 | Adrenomed Ag | Monitoreo de terapia bajo tratamiento con un aglutinante anti-adrenomodulina (adm). |
SG11202002391PA (en) | 2017-10-24 | 2020-04-29 | Sphingotec Gmbh | Selenoprotein p for prediction of a first cardiovascular event |
US11530276B2 (en) | 2017-10-25 | 2022-12-20 | 4TEEN4 Pharmaceuticals GmbH | DPP3 binder directed to and binding to specific DPP3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress |
EP3569614A1 (de) | 2018-05-18 | 2019-11-20 | Julius-Maximilians-Universität Würzburg | Verbindungen und verfahren zur immobilisierung von myostatin-inhibitoren auf der extrazellulären matrix durch transglutaminase |
EP3586865A1 (de) | 2018-06-21 | 2020-01-01 | Charité - Universitätsmedizin Berlin | Ergänzende anaphylatoxinbindemittel und deren verwendung in der behandlung einer person mit okularer wunde und/oder fibrose |
CN113056304A (zh) | 2018-08-30 | 2021-06-29 | 戴埃克斯有限公司 | 用于治疗遗传性血管性水肿发作的血浆激肽释放酶抑制剂及其用途 |
MX2021007467A (es) | 2018-12-20 | 2021-08-05 | Sphingotec Gmbh | Selenoproteina p en insuficiencia cardiaca. |
US20220211798A1 (en) | 2018-12-21 | 2022-07-07 | 4TEEN4 Pharmaceuticals GmbH | Therapy guidance and/or therapy monitoring for a treatment with angiotensin-receptor-agonist and/or a precursor thereof |
MX2021011110A (es) | 2019-03-14 | 2022-01-19 | Takeda Pharmaceuticals Co | Tratamiento de ataque de angioedema hereditario con dosis reducida de anticuerpos que se unen a calicreína plasmática humana. |
US20220291234A1 (en) | 2019-08-15 | 2022-09-15 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction in pediatric patients |
RU2712629C1 (ru) * | 2019-08-27 | 2020-01-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Способ прогнозирования сердечно-сосудистых осложнений у больных ишемической болезнью сердца в сочетании с постинфарктной аневризмой левого желудочка |
EP4021571A1 (de) | 2019-08-30 | 2022-07-06 | 4TEEN4 Pharmaceuticals GmbH | Therapieführung und therapieüberwachung zur schockbehandlung |
JP2023510854A (ja) | 2020-01-13 | 2023-03-15 | 武田薬品工業株式会社 | 小児遺伝性血管性浮腫発作を治療するための血漿カリクレイン阻害剤及びその使用 |
EP3871689A1 (de) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anti-adm-antikörper, die an den freien n-terminus binden, für einen beschleunigten übergang von adm-gly zu bio-adm bei patienten mit einem adm-gly/bio-adm-verhältnis über einem schwellenwert und kombination mit vitamin c |
CA3169447A1 (en) | 2020-02-27 | 2021-09-02 | Andreas Bergmann | Anti-adrenomedullin (adm) binder for use in therapy of patients in shock |
WO2021170838A1 (en) | 2020-02-27 | 2021-09-02 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 for therapy guidance, monitoring and stratification of nt-adm antibodies in patients with shock |
JP2023515042A (ja) | 2020-02-27 | 2023-04-12 | アドレノメト アクチェンゲゼルシャフト | ショックの治療若しくは予防において使用するための抗アドレノメデュリン(ADM)抗体若しくは抗ADM抗体フラグメント又は抗ADM非Ig足場 |
EP3922993A1 (de) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 bei patienten, die mit coronavirus infiziert sind |
MX2022011583A (es) | 2020-03-16 | 2022-10-18 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 en pacientes infectados con coronavirus. |
CN115280154A (zh) | 2020-03-16 | 2022-11-01 | 思芬构技术有限公司 | 感染冠状病毒的患者中的肾上腺髓质素原或其片段以及用针对肾上腺髓质素的结合剂进行的治疗 |
JP2023521667A (ja) | 2020-04-04 | 2023-05-25 | 武田薬品工業株式会社 | 血漿カリクレイン阻害剤及び急性呼吸窮迫症候群を処置するためのその使用 |
EP4023218A1 (de) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Kombinationstherapie für patienten mit akuter und/oder anhaltender dyspnoe |
WO2022263648A1 (en) | 2021-06-18 | 2022-12-22 | Sphingotec Gmbh | A method for predicting sepsis and septic shock |
EP4363859A1 (de) | 2021-06-29 | 2024-05-08 | berYsol GmbH | Zusammengesetzter biomarker zur identifizierung von selenmangel in einer körperflüssigkeit |
WO2024003617A2 (en) | 2022-06-30 | 2024-01-04 | Takeda Pharmaceutical Company Limited | Protein biomarkers for lanadelumab treatment |
WO2024023368A1 (en) | 2022-07-29 | 2024-02-01 | 4TEEN4 Pharmaceuticals GmbH | Prediction of an increase of dpp3 in a patient with septic shock |
WO2024023369A1 (en) | 2022-07-29 | 2024-02-01 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock |
Family Cites Families (211)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT275583B (de) | 1964-03-04 | 1969-10-27 | Plasser Bahnbaumasch Franz | Profilfreie Maschine zum Reinigen des Eisenbahnbettungsschotters |
BR6915369D0 (pt) | 1969-02-27 | 1973-03-13 | Bayer Ag | Emprego de inibidores biologicos de proteases para conservacao de orgaos tecidos e alimentos |
US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
DE2619246A1 (de) | 1976-04-30 | 1977-11-10 | Bayer Ag | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
DE2654124A1 (de) | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
CA1113397A (en) * | 1977-11-09 | 1981-12-01 | Peter F.R. Lunn | Aqueous persulphate and percarbonate composition for bleaching hair |
US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
US4299537A (en) * | 1979-06-19 | 1981-11-10 | Evans Frederick C | Interlinked variable-pitch blades for windmills and turbines |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
AU560584B2 (en) | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
US4657893A (en) | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
US4845242A (en) | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
US4609725A (en) | 1984-10-09 | 1986-09-02 | Merck & Co., Inc. | Cardiac atrial peptides |
US4931385A (en) * | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
US5444156A (en) * | 1985-07-12 | 1995-08-22 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human plasma prekallikrein |
JPH0623113B2 (ja) | 1986-01-31 | 1994-03-30 | 浩 前田 | 癌性胸・腹水貯留抑制剤 |
EP0255011A3 (de) | 1986-07-29 | 1988-11-23 | Miles Inc. | Menschliches Inter-alpha-trypsin-Inhibitorgen |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
JPH0779702B2 (ja) | 1986-11-17 | 1995-08-30 | サイオス ノバ インコーポレイテッド | 組換えアルツハイマーアミロイドタンパク |
US5187153A (en) | 1986-11-17 | 1993-02-16 | Scios Nova Inc. | Methods of treatment using Alzheimer's amyloid polypeptide derivatives |
EP0285123A3 (de) | 1987-04-03 | 1989-02-01 | Stabra AG | Verfahren zur vollständigen Mutagenese von Nucleinsäuren |
US4966852A (en) | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
IL87172A (en) | 1987-07-23 | 1994-12-29 | Univ Washington | A method of inhibiting the isolation of a purer tissue factor |
US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
GB2208511A (en) | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | ANDC of human tissue factor inhibitor |
US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US7078383B2 (en) | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP0768377A1 (de) | 1988-09-02 | 1997-04-16 | Protein Engineering Corporation | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
ES2066033T3 (es) | 1989-05-13 | 1995-03-01 | Bayer Ag | Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
US5378614A (en) | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
US5278285A (en) | 1990-02-01 | 1994-01-11 | Bayer Aktiengesellschaft | Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology |
US5278144A (en) | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
US5583107A (en) | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
IL99585A0 (en) | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
CA2055425A1 (en) | 1990-11-13 | 1992-05-14 | Hideaki Morishita | Polypeptide, dna fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same |
US20030223977A1 (en) | 1991-03-01 | 2003-12-04 | Ley Arthur Charles | Kunitz domain mutants as cathepsin G inhibitors |
US5166133A (en) | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
EP0940468A1 (de) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Änderliches Gebiet einer humanisierter Antikörper |
AU3061092A (en) | 1991-10-31 | 1993-06-07 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states |
IL104314A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
IL104324A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
IL104327A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
US5212091A (en) | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
US6063764A (en) | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US5747449A (en) * | 1992-07-13 | 1998-05-05 | Corvas International, Inc. | Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA |
AU5684594A (en) | 1992-12-02 | 1994-06-22 | Novo Nordisk A/S | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
US5436153A (en) * | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
US5426224A (en) | 1993-03-18 | 1995-06-20 | The University Of North Carolina At Chapel Hill | Mammalian DNA topoisomerase II inhibitor and method |
JP3929484B2 (ja) * | 1993-09-14 | 2007-06-13 | ジェネンテック・インコーポレーテッド | エコチンおよびその同族体を含む医薬的組成物 |
US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5759548A (en) | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
JP3805785B2 (ja) * | 1994-01-11 | 2006-08-09 | ダイアックス コープ. | カリクレイン阻害クニッツドメイン蛋白質およびその相同体 |
US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
EP0763055B1 (de) | 1994-06-02 | 1999-11-03 | Merrell Pharmaceuticals Inc. | Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung |
US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
DE69528591T2 (de) | 1994-08-05 | 2003-02-20 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
US5648331A (en) | 1994-08-26 | 1997-07-15 | G.D. Searle & Co. | Method of inhibiting tissue ischemia and reperfusion injury |
ES2276396T3 (es) * | 1994-10-18 | 2007-06-16 | Dendreon Corporation | Proteinas anticoagulantes e inhibidores de la serina proteasa extraidos de nematodos. |
US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
MX9703988A (es) * | 1994-12-12 | 1998-02-28 | Omeros Med Sys Inc | SOLUCIaN Y MÉTODO DE IRRIGACIaN PARA LA INHIBICIaN DEL DOLOR, LA INFLAMACIaN Y ES ESPASMO. |
US5914316A (en) | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
AU707323B2 (en) * | 1995-03-10 | 1999-07-08 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
US5804376A (en) | 1995-05-02 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Pancreas-derived serpin |
KR19990008458A (ko) | 1995-05-08 | 1999-01-25 | 쉬어러 피터 알. | 쿠니츠(kunitz) 타입 프로테아제 억제 물질 |
ZA963619B (en) | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
US6126933A (en) | 1995-06-27 | 2000-10-03 | Genetics Institute | Methods of treating inflammatory bowel diseases by administering IL-11 |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
JPH0959838A (ja) | 1995-08-24 | 1997-03-04 | Kuraray Co Ltd | 紡績糸 |
EP0850064A1 (de) | 1995-09-14 | 1998-07-01 | Lxr Biotechnology Inc. | Anti-apoptose zusammensetzung die eine mischung von phospholipiden enthält |
CA2232834A1 (en) | 1995-09-21 | 1997-03-27 | University Of Utah | Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells |
US5824870A (en) | 1995-11-06 | 1998-10-20 | Baszczynski; Chris | Commercial production of aprotinin in plants |
US5736364A (en) * | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
BR9509985A (pt) * | 1995-12-12 | 1998-11-03 | Omeros Med Sys Inc | Solução para irrigação e método para inibição de dor inflamação e esparmo |
WO1997033996A2 (en) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Human bikunin |
US6013763A (en) * | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
JP3657700B2 (ja) * | 1996-06-18 | 2005-06-08 | 新日本石油化学株式会社 | カサ高性不織布の製造方法 |
US5869637A (en) | 1996-07-22 | 1999-02-09 | Incyte Pharmaceuticals, Inc. | Human Kallikrein |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
US6255455B1 (en) | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
WO1998033920A2 (en) | 1997-01-31 | 1998-08-06 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
US5786238A (en) * | 1997-02-13 | 1998-07-28 | Generyal Dynamics Information Systems, Inc. | Laminated multilayer substrates |
US5962300A (en) | 1997-03-26 | 1999-10-05 | Incyte Pharmaceuticals, Inc. | Human kallikrein |
DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
JP2003525845A (ja) | 1997-10-28 | 2003-09-02 | ヴィヴァス・インコーポレイテッド | 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与 |
US6362276B1 (en) | 1998-01-07 | 2002-03-26 | Debio Recherche Pharmaceutique S.A. | Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom |
ATE268609T1 (de) | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
AU2855499A (en) | 1998-03-24 | 1999-10-18 | Nof Corporation | Oxirane derivatives and process for producing the same |
US6017723A (en) | 1998-03-27 | 2000-01-25 | Long Island Jewish Medical Center | Method for isolating inhibitors of protease activity |
US6001596A (en) | 1998-05-07 | 1999-12-14 | Incyte Pharmaceuticals, Inc. | Growth-associated protease inhibitor heavy chain precursor |
US6087473A (en) * | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
EP1082431A2 (de) * | 1998-06-03 | 2001-03-14 | Scios Inc. | Protease-inhibitor-peptiden |
CA2728907C (en) | 1998-08-06 | 2015-11-24 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
JP2002524076A (ja) | 1998-09-03 | 2002-08-06 | ザイモジェネティクス,インコーポレイティド | KunitzドメインポリペプチドZKUN6 |
US7067144B2 (en) | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
CA2352538A1 (en) | 1998-11-30 | 2000-06-08 | Eli Lilly And Company | Erythropoietic compounds |
ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
US20030012969A1 (en) | 1999-04-06 | 2003-01-16 | Clark Bert Thomas | Soluble membrane strengthened paper products |
IL145894A0 (en) | 1999-04-29 | 2002-07-25 | Novo Nordisk As | Use of heparin-binding antagonists in the inhibition of bradykinin release |
US6605316B1 (en) | 1999-07-31 | 2003-08-12 | The Regents Of The University Of California | Structures and fabrication techniques for solid state electrochemical devices |
US6180607B1 (en) * | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
EP1212422B1 (de) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Humane antikörper gegen ctla-4 und deren verwendungen |
MXPA02004671A (es) | 1999-11-12 | 2004-09-10 | Maxygen Holdings Ltd | Conjugados de interferon gamma. |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
US6376604B2 (en) | 1999-12-22 | 2002-04-23 | Shearwater Corporation | Method for the preparation of 1-benzotriazolylcarbonate esters of poly(ethylene glycol) |
US6544760B2 (en) | 1999-12-22 | 2003-04-08 | Zymogenetics, Inc. | Kunitz domain polypeptide Zkun11 |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
US20020102703A1 (en) | 1999-12-29 | 2002-08-01 | Sheppard Paul O. | Kunitz domain polypeptide zkun10 |
GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
WO2001068707A1 (en) | 2000-03-13 | 2001-09-20 | Eli Lilly And Company | Human hepatocyte growth factor activator inhibitor homologue |
ES2484966T3 (es) | 2000-04-12 | 2014-08-12 | Novozymes Biopharma Dk A/S | Proteínas de fusión de albúmina |
CN1331213A (zh) | 2000-06-30 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人大蛋白10.01和编码这种多肽的多核苷酸 |
DE10034357C1 (de) | 2000-07-14 | 2001-12-13 | Elotherm Gmbh | Verfahren und Vorrichtung zum Härten von Flächen an Bauteilen |
US7060800B2 (en) | 2000-09-08 | 2006-06-13 | Schering Corporation | Antibodies binding the TNF related protein, TNF-X |
WO2002036158A1 (en) | 2000-10-31 | 2002-05-10 | Debiopharm S.A. | Suspension of an epi-hne protein, process of preparation thereof, dry powder aerosol derived therefrom, pharmaceutical compositions containing said suspension or aerosol, and their uses |
WO2002061131A2 (en) | 2000-12-04 | 2002-08-08 | Bristol-Myers Squibb Company | Human single nucleotide polymorphisms |
TW593427B (en) | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
JP2004531550A (ja) | 2001-05-11 | 2004-10-14 | アラダイム コーポレーション | 吸入によって送達されるタンパク質の、分子性状の最適化方法および製剤 |
CA2447236A1 (en) | 2001-05-21 | 2002-11-28 | Nektar Therapeutics | Pulmonary administration of chemically modified insulin |
US20040152633A1 (en) | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
JP4287269B2 (ja) | 2001-07-10 | 2009-07-01 | 日本電産サンキョー株式会社 | バルブ駆動装置 |
AU2002358921A1 (en) | 2001-07-10 | 2003-04-28 | Omnio Ab | Novel drug targets for arthritis |
US20050222023A1 (en) | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
EP1572930A4 (de) | 2002-02-07 | 2008-07-09 | Novozymes Delta Ltd | Mit albumin fusionierte kunitz-domänenpeptide |
AU2003231865A1 (en) | 2002-05-31 | 2003-12-19 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
DK1531791T3 (da) | 2002-06-07 | 2010-11-01 | Dyax Corp | Forebyggelse og begrænsning af iskæmi |
KR100637981B1 (ko) | 2002-07-24 | 2006-10-23 | 에프. 호프만-라 로슈 아게 | 페길화된 t20 폴리펩타이드 |
MXPA05000796A (es) | 2002-07-24 | 2005-04-19 | Hoffmann La Roche | Aditivos de acidos polialquilenglicolicos. |
PT2386310T (pt) * | 2002-08-28 | 2019-02-05 | Dyax Corp | Métodos para preservar órgãos e tecidos |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
BR0317742A (pt) | 2002-12-26 | 2005-11-22 | Mountain View Pharmaceuticals | Conjugados poliméricos de interferon-beta com potência biológica aumentada |
JP2007524348A (ja) | 2003-01-07 | 2007-08-30 | ダイアックス、コープ | クニッツドメインライブラリー |
DE602004019761D1 (de) | 2003-01-08 | 2009-04-16 | Novartis Vaccines & Diagnostic | Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante |
EP1589949B1 (de) | 2003-01-08 | 2008-08-13 | Novartis Vaccines and Diagnostics, Inc. | Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
CA2531062A1 (en) | 2003-07-02 | 2005-01-13 | Emory University | Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury |
WO2005019270A2 (en) | 2003-08-14 | 2005-03-03 | Dyax Corp. | Endotheliase-2 ligands |
WO2005021556A2 (en) | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
CA2536873C (en) | 2003-08-29 | 2019-09-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
WO2005027753A1 (en) | 2003-09-19 | 2005-03-31 | St. Jude Medical, Inc. | Apparatus and methods for tissue gathering and securing |
JP2007507538A (ja) | 2003-10-02 | 2007-03-29 | エラン ファーマシューティカルズ,インコーポレイテッド | 疼痛軽減方法 |
US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
US20050164945A1 (en) | 2003-10-21 | 2005-07-28 | Andrew Nixon | Endotheliase-1 ligands |
US20070253949A1 (en) | 2004-02-03 | 2007-11-01 | Stefan Golz | Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1) |
EP1736465A4 (de) | 2004-03-31 | 2009-06-17 | Ajinomoto Kk | Anilinderivative |
EP1807451A2 (de) | 2004-08-03 | 2007-07-18 | Dyax Corporation | Hk1-bindende proteine |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US20060111296A1 (en) | 2004-11-22 | 2006-05-25 | Dyax Corp. | Plasmin-inhibitory therapies |
ITMI20042442A1 (it) | 2004-12-21 | 2005-03-21 | Aliveris S R L | Paste alimentari con migliorate caratteristiche di digeribilita' |
RU2514878C2 (ru) | 2004-12-23 | 2014-05-10 | Ксл Бехринг Гмбх | Предотвращение образования и/или стабилизации тромбов |
WO2006089005A2 (en) | 2005-02-17 | 2006-08-24 | Bristol-Myers Squibb Company | Combination of selective factor viia and/or xia and plasma kallikrein inhibitors |
WO2006091459A2 (en) | 2005-02-24 | 2006-08-31 | Joslin Diabetes Center, Inc. | Compositions and methods for treating vascular permeability |
PL1877435T5 (pl) | 2005-05-04 | 2021-09-27 | Zealand Pharma A/S | Analogi peptydu glukagonopodobnego 2 (GLP-2) |
MXPA06011291A (es) | 2005-09-30 | 2007-06-08 | 9141 0720 Quebec Inc | Dispositivo de operacion de cierre motorizado con sistema de control electronico. |
US20070079096A1 (en) | 2005-09-30 | 2007-04-05 | Chih-Wei Chen | Data storage unit access authorization table automatic rebuilding method and system |
EP1981519B1 (de) | 2005-12-29 | 2017-12-27 | Dyax Corp. | Proteasehemmung |
US7276480B1 (en) * | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
WO2007106746A2 (en) | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
DK1854477T3 (en) | 2006-03-16 | 2016-11-28 | Dyax Corp | Peptide inhibitors of plasma kallikrein for use in the treatment of eye disorders |
US20080031426A1 (en) | 2006-06-27 | 2008-02-07 | Weeks Walter L | Audio, video, and navigational law enforcement system and method |
EP1873344A1 (de) | 2006-06-30 | 2008-01-02 | Sika Technology AG | Mittels Silikon agedichtete Verklebung |
WO2008016883A2 (en) | 2006-07-31 | 2008-02-07 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
WO2008060764A2 (en) | 2006-10-05 | 2008-05-22 | Drugtech Corporation | Topical therapies for oral mucositis and other conditions |
AU2008289005A1 (en) | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
CA2695012A1 (en) | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
JP2011511647A (ja) | 2008-02-13 | 2011-04-14 | ダイアックス コーポレイション | 特異的結合対を作製するための改善された方法 |
DE102008027574A1 (de) | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
DE102008033095A1 (de) | 2008-07-15 | 2010-01-28 | Uhde Gmbh | Vorrichtung zur Schlackeabführung aus einem Kohlevergasungsreaktor |
WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
LT3459564T (lt) | 2010-01-06 | 2022-03-10 | Takeda Pharmaceutical Company Limited | Plazmos kalikreiną surišantys baltymai |
IL310186A (en) | 2011-01-06 | 2024-03-01 | Takeda Pharmaceuticals Co | KALLIKREIN PLASMA BINDING PROTEINS |
US8691861B2 (en) | 2011-04-13 | 2014-04-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
ES2718347T3 (es) | 2013-01-20 | 2019-07-01 | Dyax Corp | Evaluación, ensayos y tratamiento de trastornos mediados por pKal |
AU2015235967B2 (en) | 2014-03-27 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Compositions and methods for treatment of diabetic macular edema |
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