ATE529444T1 - Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten - Google Patents
Inhibitoren des humanplasmins, die sich von den kunitz domänen ableitenInfo
- Publication number
- ATE529444T1 ATE529444T1 AT04022346T AT04022346T ATE529444T1 AT E529444 T1 ATE529444 T1 AT E529444T1 AT 04022346 T AT04022346 T AT 04022346T AT 04022346 T AT04022346 T AT 04022346T AT E529444 T1 ATE529444 T1 AT E529444T1
- Authority
- AT
- Austria
- Prior art keywords
- kunitz domains
- human plasmin
- inhibitors derived
- plasmin inhibitors
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/515—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics
- C04B35/58—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides
- C04B35/584—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride
- C04B35/593—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering
- C04B35/5935—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering obtained by gas pressure sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17965894A | 1994-01-11 | 1994-01-11 | |
US20826594A | 1994-03-10 | 1994-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE529444T1 true ATE529444T1 (de) | 2011-11-15 |
Family
ID=26875521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04022346T ATE529444T1 (de) | 1994-01-11 | 1995-01-11 | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
AT95908460T ATE277081T1 (de) | 1994-01-11 | 1995-01-11 | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95908460T ATE277081T1 (de) | 1994-01-11 | 1995-01-11 | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
Country Status (10)
Country | Link |
---|---|
US (11) | US6010880A (de) |
EP (2) | EP1489097B1 (de) |
JP (5) | JP4137997B2 (de) |
AT (2) | ATE529444T1 (de) |
CA (1) | CA2180954C (de) |
DE (1) | DE69533544T2 (de) |
DK (2) | DK1489097T3 (de) |
ES (2) | ES2229236T3 (de) |
PT (2) | PT737207E (de) |
WO (1) | WO1995018830A2 (de) |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
EP1489097B1 (de) | 1994-01-11 | 2011-10-19 | Dyax Corporation | Inhibitoren des Humanplasmins, die sich von den Kunitz Domänen ableiten |
US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
ATE239501T1 (de) * | 1995-06-07 | 2003-05-15 | Chiron Corp | Regulierung der neutrophil elastase synthese und freisetzung |
US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
DE69735996T2 (de) | 1996-03-11 | 2007-02-15 | Bayer Corp. | Menschlicher bikunin |
ATE397061T1 (de) * | 1997-01-08 | 2008-06-15 | Invitrogen Corp | Verfahren zur herstellung von proteinen |
US5981471A (en) | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
US6946439B2 (en) | 1997-02-06 | 2005-09-20 | Entre Med, Inc. | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
US20060025329A1 (en) * | 1997-02-06 | 2006-02-02 | Todd Hembrough | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
US20020076728A1 (en) * | 1997-03-21 | 2002-06-20 | Maclennan John Moore | Engineering affinity ligands for macromolecules |
US6087473A (en) * | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
US6380354B1 (en) | 1998-09-03 | 2002-04-30 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
CA2342072C (en) * | 1998-09-03 | 2005-01-11 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
US20030032146A1 (en) * | 2001-07-10 | 2003-02-13 | Dwulet Francis Edward | Enzyme/tag binding and detection system |
US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
NZ579419A (en) * | 2002-02-07 | 2011-02-25 | Dyax Corp | Albumin-fused kunitz domain peptides |
PT1531791E (pt) * | 2002-06-07 | 2010-12-16 | Dyax Corp | Prevenção e redução da isquémia |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
WO2004019968A1 (en) | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
AU2004204095B2 (en) * | 2003-01-07 | 2009-07-30 | Dyax Corporation | Kunitz domain library |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
WO2005021556A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
US20050089515A1 (en) * | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
US7740973B2 (en) * | 2004-08-05 | 2010-06-22 | General Motors Corporation | Modular electrochemical power system |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US20060111296A1 (en) * | 2004-11-22 | 2006-05-25 | Dyax Corp. | Plasmin-inhibitory therapies |
EP1858542A4 (de) | 2005-02-24 | 2009-08-19 | Joslin Diabetes Center Inc | Zusammensetzungen und verfahren zur behandlung von gefässpermeabilität |
GB0521404D0 (en) * | 2005-10-20 | 2005-11-30 | Ares Trading Sa | Kunitz domain containing protein |
WO2007070372A2 (en) * | 2005-12-09 | 2007-06-21 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
AU2013202021B2 (en) * | 2005-12-29 | 2016-03-10 | The Regents Of The University Of California | Methods and compositions related to mutant Kunitz domain of TFPI-2 |
JP5770966B2 (ja) * | 2005-12-29 | 2015-08-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Tfpi−2の変異体クニッツドメインiに関連した方法および組成物 |
SI1981519T1 (en) | 2005-12-29 | 2018-05-31 | Dyax Corp. | INHIBITION PROTEAZE |
EP1981538B1 (de) | 2005-12-30 | 2014-09-17 | Dyax Corporation | Metalloproteinasebindende proteine |
BRPI0708687A2 (pt) * | 2006-03-08 | 2011-06-07 | Bayer Healthcare Ag | domìnios de kunitz quiméricos e seu uso |
EP2001500A4 (de) * | 2006-03-10 | 2010-07-28 | Dyax Corp | Formulierungen für ecallantid |
PT1854477T (pt) * | 2006-03-16 | 2016-11-10 | Dyax Corp | Inibidores peptidicos da calicreína plasmática e sua utilização no tratamento de doenças oftalmológicas |
DK2374472T3 (en) | 2006-03-16 | 2018-08-13 | Dyax Corp | Compositions and Methods for the Treatment of Eye Disorders |
US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
EP2195010A4 (de) * | 2007-08-21 | 2012-03-14 | Genzyme Corp | Behandlung mit kallikrein-inhibitoren |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
WO2009030464A2 (de) * | 2007-09-08 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | HERSTELLUNG UND VERWENDUNG VON VARIANTEN HUMANER KUNITZ-TYP PROTEASE-INHIBITOREN (hKTPI) |
JP5840494B2 (ja) | 2008-10-02 | 2016-01-06 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | Cd86アンタゴニストの多標的結合タンパク質 |
CN102292352A (zh) * | 2008-10-10 | 2011-12-21 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
DK2379096T3 (da) | 2008-12-19 | 2019-11-25 | Baxalta GmbH | TFPI-inhibitorer og fremgangsmåder til anvendelse |
CA2744235A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
US20130052195A1 (en) | 2009-12-23 | 2013-02-28 | Emergent Product Development Seattle,LLC | Compositions Comprising TNF-alpha and IL-6 Antagonists and Methods of Use Thereof |
CN103124743A (zh) | 2009-12-29 | 2013-05-29 | 新兴产品开发西雅图有限公司 | Ron结合构建物及其使用方法 |
ES2688093T3 (es) * | 2010-01-06 | 2018-10-30 | Dyax Corp. | Proteínas de unión a calicreína plasmática |
NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
WO2012094587A1 (en) | 2011-01-06 | 2012-07-12 | Dyax Corp. | Plasma kallikrein binding proteins |
CN103842383B (zh) | 2011-05-16 | 2017-11-03 | 健能隆医药技术(上海)有限公司 | 多特异性fab融合蛋白及其使用方法 |
EP2827883B1 (de) | 2012-03-21 | 2019-05-08 | Baxalta GmbH | Tfpi inhibitoren und deren verwendung |
US10202452B2 (en) | 2012-04-20 | 2019-02-12 | Aptevo Research And Development Llc | CD3 binding polypeptides |
ES2813867T3 (es) * | 2012-08-08 | 2021-03-25 | Daiichi Sankyo Co Ltd | Biblioteca de péptidos y su uso |
EP2971039B1 (de) | 2013-03-14 | 2020-01-01 | Immusoft Corporation | Verfahren zur in-vitro-speicher-b-zellen-differenzierung und -transduktion mit vsv-g-pseudotypisierten viralen vektoren |
CN105377888A (zh) * | 2013-03-15 | 2016-03-02 | 加利福尼亚大学董事会 | 纤维蛋白溶解的双反应性的有效的Kunitz抑制剂 |
DK3027204T3 (da) | 2013-07-29 | 2022-04-19 | 2Seventy Bio Inc | Flerdelte signaleringsproteiner og anvendelser deraf |
NZ719840A (en) | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
HUE052573T2 (hu) | 2013-12-20 | 2021-05-28 | Hutchinson Fred Cancer Res | Jelölt kiméra effektormolekulák és receptoraik |
BR112016022318A2 (pt) | 2014-03-27 | 2017-10-31 | Dyax Corp | método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo |
ES2929570T3 (es) | 2014-12-19 | 2022-11-30 | Immusoft Corp | Células B para administración in vivo de agentes terapéuticos |
RU2755227C2 (ru) | 2015-03-05 | 2021-09-14 | Фред Хатчинсон Кансэр Рисёч Сентер | Иммуномодулирующие слитые белки и пути их применения |
JP6985934B2 (ja) | 2015-04-29 | 2021-12-22 | フレッド ハッチンソン キャンサー リサーチ センター | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
MY197562A (en) | 2015-09-21 | 2023-06-23 | Aptevo Res & Development Llc | Cd3 binding polypeptides |
US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
CA3017776A1 (en) | 2016-03-15 | 2017-09-21 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
AU2017250295B2 (en) | 2016-04-14 | 2022-08-25 | Fred Hutchinson Cancer Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
EP4269594A3 (de) | 2017-02-17 | 2023-12-20 | Fred Hutchinson Cancer Center | Kombinationstherapien zur behandlung von bcma-bedingten krebsarten und autoimmunerkrankungen |
AU2018236461A1 (en) | 2017-03-17 | 2019-09-19 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
JP7431735B2 (ja) | 2017-12-14 | 2024-02-15 | 2セブンティ バイオ インコーポレイテッド | Daricインターロイキン受容体 |
US20220098613A1 (en) | 2018-09-12 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Reducing cd33 expression to selectively protect therapeutic cells |
CN114729383A (zh) | 2019-07-02 | 2022-07-08 | 弗莱德哈钦森癌症研究中心 | 重组ad35载体及相关基因疗法改进 |
WO2021198534A1 (en) | 2020-04-04 | 2021-10-07 | Oxurion NV | Plasma kallikrein inhibitors for use in the treatment of coronaviral disease |
CA3181963A1 (en) | 2020-05-04 | 2021-11-11 | Immunorizon Ltd. | Precursor tri-specific antibody constructs and methods of use thereof |
WO2023144030A1 (en) | 2022-01-31 | 2023-08-03 | Oxurion NV | Plasma kallikrein inhibitor therapy for anti-vegf sensitization |
WO2023148016A1 (en) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarker for plasma kallikrein inhibitor therapy response |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
DE2619246A1 (de) * | 1976-04-30 | 1977-11-10 | Bayer Ag | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2654124A1 (de) * | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
US4657893A (en) * | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
US4845242A (en) * | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
ES2066033T3 (es) * | 1989-05-13 | 1995-03-01 | Bayer Ag | Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
US7413537B2 (en) * | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
US5278285A (en) | 1990-02-01 | 1994-01-11 | Bayer Aktiengesellschaft | Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology |
US5278144A (en) | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
US5583107A (en) | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
JPH0584083A (ja) | 1990-11-13 | 1993-04-06 | Mochida Pharmaceut Co Ltd | 新規ポリペプチド、それをコードする新規dna、新規ポリペプチドの製造方法、新規医薬組成物、および新規酵素阻害方法 |
US5166133A (en) | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
DE69209390D1 (de) * | 1991-06-28 | 1996-05-02 | Wecotec Ltd | Überführung von Tüchern |
IL104325A (en) * | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
IL104326A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
IL104324A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
IL107831A0 (en) * | 1992-12-02 | 1994-05-30 | Zymogenetics Inc | Novel human amyloid protein precursor homolog and kunitz-type inhibitor |
CA2170030A1 (en) | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
EP1489097B1 (de) | 1994-01-11 | 2011-10-19 | Dyax Corporation | Inhibitoren des Humanplasmins, die sich von den Kunitz Domänen ableiten |
JP3805785B2 (ja) | 1994-01-11 | 2006-08-09 | ダイアックス コープ. | カリクレイン阻害クニッツドメイン蛋白質およびその相同体 |
US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
CA2229435A1 (en) | 1995-09-14 | 1997-03-20 | Lxr Biotechnology Inc. | Compositions with anti-apoptotic activity, containing a mixture of phospholipids |
US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
EP0890638A4 (de) | 1996-01-08 | 2001-08-22 | Nissin Food Products Ltd | Inhibitor von krebsmetastasen. |
JP3357807B2 (ja) * | 1997-01-13 | 2002-12-16 | 株式会社東芝 | 受信装置および移相器 |
US7383135B1 (en) * | 1998-05-04 | 2008-06-03 | Vertex Pharmaceuticals Incorporated | Methods of designing inhibitors for JNK kinases |
JP2000106882A (ja) | 1998-10-02 | 2000-04-18 | Chemo Sero Therapeut Res Inst | 癌転移増殖抑制作用を有する血漿蛋白断片産生酵素および当該酵素により断片化された血漿蛋白断片 |
EP1243276A1 (de) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Langgestreckte und mehrfachige Abstandhaltern enthaltende aktivierbare Prodroge |
IL159015A0 (en) | 2001-05-25 | 2004-05-12 | Genset Sa | Polypeptides, their preparation and use |
US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
NZ579419A (en) | 2002-02-07 | 2011-02-25 | Dyax Corp | Albumin-fused kunitz domain peptides |
PT1531791E (pt) | 2002-06-07 | 2010-12-16 | Dyax Corp | Prevenção e redução da isquémia |
WO2004019968A1 (en) | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
AU2004204095B2 (en) * | 2003-01-07 | 2009-07-30 | Dyax Corporation | Kunitz domain library |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US20050089515A1 (en) * | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
-
1995
- 1995-01-11 EP EP04022346A patent/EP1489097B1/de not_active Expired - Lifetime
- 1995-01-11 DE DE69533544T patent/DE69533544T2/de not_active Expired - Lifetime
- 1995-01-11 PT PT95908460T patent/PT737207E/pt unknown
- 1995-01-11 JP JP51866795A patent/JP4137997B2/ja not_active Expired - Fee Related
- 1995-01-11 AT AT04022346T patent/ATE529444T1/de active
- 1995-01-11 PT PT04022346T patent/PT1489097E/pt unknown
- 1995-01-11 WO PCT/US1995/000298 patent/WO1995018830A2/en active IP Right Grant
- 1995-01-11 US US08/676,124 patent/US6010880A/en not_active Expired - Lifetime
- 1995-01-11 CA CA002180954A patent/CA2180954C/en not_active Expired - Fee Related
- 1995-01-11 ES ES95908460T patent/ES2229236T3/es not_active Expired - Lifetime
- 1995-01-11 ES ES04022346T patent/ES2375561T3/es not_active Expired - Lifetime
- 1995-01-11 AT AT95908460T patent/ATE277081T1/de active
- 1995-01-11 DK DK04022346.3T patent/DK1489097T3/da active
- 1995-01-11 DK DK95908460T patent/DK0737207T3/da active
- 1995-01-11 EP EP95908460A patent/EP0737207B1/de not_active Expired - Lifetime
-
1999
- 1999-01-29 US US09/240,136 patent/US6103499A/en not_active Expired - Lifetime
- 1999-10-08 US US09/414,878 patent/US6071723A/en not_active Expired - Lifetime
-
2000
- 2000-08-15 US US09/638,770 patent/US6423498B1/en not_active Expired - Fee Related
-
2002
- 2002-06-11 US US10/167,351 patent/US6953674B2/en not_active Expired - Fee Related
-
2005
- 2005-03-18 US US11/083,742 patent/US8431359B2/en not_active Expired - Fee Related
-
2007
- 2007-10-24 JP JP2007276165A patent/JP2008113657A/ja active Pending
- 2007-10-30 US US11/928,448 patent/US7919462B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/928,351 patent/US20090036365A1/en not_active Abandoned
- 2007-10-30 US US11/928,497 patent/US20080182283A1/en not_active Abandoned
- 2007-10-31 US US11/932,411 patent/US20090023651A1/en not_active Abandoned
-
2008
- 2008-11-19 JP JP2008295610A patent/JP2009183281A/ja active Pending
-
2011
- 2011-02-25 US US13/034,967 patent/US20110152193A1/en not_active Abandoned
-
2012
- 2012-02-29 JP JP2012044051A patent/JP2012111779A/ja active Pending
-
2013
- 2013-06-19 JP JP2013128491A patent/JP2013249302A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69533544D1 (de) | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten | |
EP1484339A3 (de) | Kallikreinhemmende "Kunitz-Domäne"Proteine dafür kodierende Nukleinsäure | |
ATE239079T1 (de) | Gewebeinhibitor für metalloproteasen type 3 (timp-3) | |
DE69922958D1 (de) | Hcv hüllproteine partikel : verwendung für therapeutische impfung | |
ATE407949T1 (de) | Charakterisierung der proteinfamilie von soc/crac kalziumkanälen | |
DK0733067T3 (da) | N-terminalt kemisk modificerede proteinpræparater og fremgangsmåder | |
DK1005540T3 (da) | IKK-beta-proteiner, nukleinsyrer og fremgangsmåder | |
CY1111950T1 (el) | 32 ανθρωπινες εκκρινομενες πρωτεϊνες | |
DE68929430D1 (de) | Fibronektin bindendes Protein | |
MXPA02008239A (es) | Gen humano de la esquizofrenia. | |
DE69737651D1 (de) | Cortistatin: neuropeptide, zusammensetzungen und methoden | |
DK0817851T3 (da) | DNA, der koder for humant papillomvirus type 18 | |
DK0877803T3 (da) | OB-proteinreceptor og relaterede sammensætninger og fremgangsmåder | |
DK0786004T3 (da) | Kloning, ekspression og karakterisering af en hidtil ukendt form af phosphatidylinositol-3-kinase | |
SE9602822D0 (sv) | New receptor | |
SE8801723D0 (sv) | Fibronectin binding protein as well as its preparation | |
WO2001064876A3 (en) | Human schizophrenia gene | |
DE69529235T2 (de) | Menschliche dnase i varianten | |
SE9604439D0 (sv) | New receptor | |
WO2001075010A3 (fr) | Nouveau polypeptide, proteine humaine de transduction nucleaire 25 contenant un domaine structurel atp/gtp, et polynucleotide codant pour ce polypeptide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1489097 Country of ref document: EP |