ATE239079T1 - Gewebeinhibitor für metalloproteasen type 3 (timp-3) - Google Patents

Gewebeinhibitor für metalloproteasen type 3 (timp-3)

Info

Publication number
ATE239079T1
ATE239079T1 AT94115578T AT94115578T ATE239079T1 AT E239079 T1 ATE239079 T1 AT E239079T1 AT 94115578 T AT94115578 T AT 94115578T AT 94115578 T AT94115578 T AT 94115578T AT E239079 T1 ATE239079 T1 AT E239079T1
Authority
AT
Austria
Prior art keywords
timp
type
hibitor
metalloproteases
tissue
Prior art date
Application number
AT94115578T
Other languages
English (en)
Inventor
Scott M Silbiger
Raymond A Koski
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22462365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE239079(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE239079T1 publication Critical patent/ATE239079T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT94115578T 1993-10-06 1994-10-04 Gewebeinhibitor für metalloproteasen type 3 (timp-3) ATE239079T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/134,231 US6562596B1 (en) 1993-10-06 1993-10-06 Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Publications (1)

Publication Number Publication Date
ATE239079T1 true ATE239079T1 (de) 2003-05-15

Family

ID=22462365

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03005363T ATE412749T1 (de) 1993-10-06 1994-10-04 Chemisch modifizierter gewebeinhibitor für metalloproteasen type 3 (timp-3)
AT94115578T ATE239079T1 (de) 1993-10-06 1994-10-04 Gewebeinhibitor für metalloproteasen type 3 (timp-3)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03005363T ATE412749T1 (de) 1993-10-06 1994-10-04 Chemisch modifizierter gewebeinhibitor für metalloproteasen type 3 (timp-3)

Country Status (12)

Country Link
US (5) US6562596B1 (de)
EP (3) EP0648838B1 (de)
AT (2) ATE412749T1 (de)
AU (1) AU7928194A (de)
DE (2) DE69432581T2 (de)
DK (2) DK1319669T3 (de)
ES (2) ES2315438T3 (de)
IL (4) IL111171A (de)
PT (2) PT1319669E (de)
SI (2) SI0648838T1 (de)
WO (1) WO1995009918A1 (de)
ZA (1) ZA947781B (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
DE19524720A1 (de) * 1995-07-12 1997-01-16 Hoechst Ag Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3"
GB2318732A (en) * 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AU3759100A (en) * 1999-03-24 2000-10-09 B.F. Goodrich Company, The Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
GB9921418D0 (en) * 1999-09-11 1999-11-10 Univ Sheffield Cell transfection
AU2094101A (en) * 1999-12-13 2001-06-18 Duanqing Pei Leukolysin/mmp25/mt6-mmp
AU2001225487A1 (en) * 2000-01-19 2001-07-31 Dnavec Research Inc. Use of paramyxovirus vector in gene transfer into blood vessel
US6562955B2 (en) * 2000-03-17 2003-05-13 Tosoh Corporation Oligonucleotides for detection of Vibrio parahaemolyticus and detection method for Vibrio parahaemolyticus using the same oligonucleotides
GB0015761D0 (en) * 2000-06-27 2000-08-16 Univ Bristol Polypeptide
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
DE10102784A1 (de) * 2001-01-22 2002-08-01 Henkel Kgaa Kosmetische oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
AU2003219029B2 (en) * 2002-03-08 2008-09-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V Use of EGFR transactivation inhibitors in human cancer
AUPS282002A0 (en) * 2002-06-06 2002-06-27 Gropep Limited Metalloproteinase inhibitors
US20050053942A1 (en) * 2002-06-24 2005-03-10 Sakari Kauppinen Methods and systems for detection and isolation of a nucleotide sequence
US7060795B2 (en) * 2002-12-19 2006-06-13 Kimberly-Clark Worldwide, Inc. Wound care compositions
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
US7183256B2 (en) 2003-03-21 2007-02-27 Cleveland Clinic Foundation TIMP3 as VEGF inhibitor
EP1613269B1 (de) 2003-04-04 2015-02-25 Incyte Corporation Zusammensetzungen, verfahren und kits in zusammenhang mit her-2 spaltung
CA2534352A1 (en) 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
JP2007528409A (ja) 2004-03-09 2007-10-11 アリバ ファーマシューティカルズ, インコーポレイテッド プロテアーゼインヒビターの低用量吸入による慢性閉塞性肺疾患の処置
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
US9163076B2 (en) * 2005-03-01 2015-10-20 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
CN101291953A (zh) * 2005-07-29 2008-10-22 帝国改革有限公司 突变的timp-3
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
EP2459213A1 (de) * 2009-07-31 2012-06-06 Amgen Inc. Metalloproteinase-typ-3 (timp-3)-gewebehemmer bindende polypeptide, zusammensetzungen und verfahren
US8710014B2 (en) * 2010-10-08 2014-04-29 Proteapex Therapeutics Llc Compositions and methods for inhibition of MMP13:MMP-substrate interactions
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
NZ611076A (en) 2010-12-01 2015-09-25 Alderbio Holdings Llc Anti-ngf compositions and use thereof
WO2013030362A1 (en) 2011-08-31 2013-03-07 Universität Zürich Prorektorat Mnw Modulators of mir-323-3p for the prevention or treatment of rheumatoid arthritis
CA2865170C (en) 2012-02-21 2020-12-22 Cytonics Corporation Systems, compositions, and methods for transplantation
BR112015022491A2 (pt) * 2013-03-14 2017-10-24 Amgen Inc variantes de inibidor de tecido de metaloprotease tipo três (timp-3), ácido nucleico isolado, vetor de expressão, célula hospedeira isolada e método para produzir uma muteína de timp-3 recombinante, bem como composição e seu uso
WO2015021308A1 (en) * 2013-08-07 2015-02-12 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples
WO2015031654A2 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
CN105764523A (zh) * 2013-09-18 2016-07-13 詹姆斯库克大学 抗炎蛋白及使用方法
JP2016532456A (ja) 2013-09-18 2016-10-20 ジェームス・クック・ユニバーシティー 改変型抗炎症性タンパク質及び使用方法
EP3421066B1 (de) 2013-10-24 2021-03-03 Amgen Inc. Injektor und verfahren zur montage
EP3060281B1 (de) 2013-10-24 2019-01-30 Amgen Inc. Arzneimittelabgabesystem mit temperaturempfindlicher steuerung
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
JP6640113B2 (ja) 2014-05-07 2020-02-05 アムジエン・インコーポレーテツド 衝撃低減要素を有する自動注入器
CN112237662B (zh) 2014-06-03 2022-10-21 安姆根有限公司 药物递送系统和使用方法
WO2016025850A1 (en) 2014-08-15 2016-02-18 Amgen Inc. Pericardial drug delivery device and method of use
MX382490B (es) * 2014-08-27 2025-03-13 Amgen Inc Variantes de inhibidor de tejido de metaloproteinasa tipo tres (timp-3), composiciones y metodos
WO2016061220A2 (en) 2014-10-14 2016-04-21 Amgen Inc. Drug injection device with visual and audio indicators
EP3848072A1 (de) 2014-12-19 2021-07-14 Amgen Inc. Medikamentenabgabevorrichtung mit näherungssensor
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
CA2976935C (en) 2015-02-17 2020-03-10 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
WO2016138434A1 (en) 2015-02-27 2016-09-01 Amgen Inc. Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement
WO2017011336A1 (en) 2015-07-10 2017-01-19 E.&J. Gallo Winery System and method for dispensing a beverage
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
ES2755717T3 (es) 2015-12-09 2020-04-23 Amgen Inc Autoinyector con tapa de señalización
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
US11200298B2 (en) 2016-03-15 2021-12-14 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
WO2017192287A1 (en) 2016-05-02 2017-11-09 Amgen Inc. Syringe adapter and guide for filling an on-body injector
EP3455142B1 (de) 2016-05-13 2023-08-09 Amgen Inc. Ampullenhülsenanordnung
US11238150B2 (en) 2016-05-16 2022-02-01 Amgen Inc. Data encryption in medical devices with limited computational capability
US11541176B2 (en) 2016-06-03 2023-01-03 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
WO2018004842A1 (en) 2016-07-01 2018-01-04 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
WO2018034784A1 (en) 2016-08-17 2018-02-22 Amgen Inc. Drug delivery device with placement detection
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
WO2018136398A1 (en) 2017-01-17 2018-07-26 Amgen Inc. Injection devices and related methods of use and assembly
US11752258B2 (en) 2017-02-17 2023-09-12 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
US11369736B2 (en) 2017-02-17 2022-06-28 Amgen Inc. Cannula insertion and retraction mechanisms
CA3050927A1 (en) 2017-03-06 2018-09-13 Brian Stonecipher Drug delivery device with activation prevention feature
KR102627069B1 (ko) 2017-03-07 2024-01-18 암겐 인코포레이티드 과압에 의한 바늘 삽입
EP3592404A1 (de) 2017-03-09 2020-01-15 Amgen Inc. Einführmechanismus für eine arzneimittelabgabevorrichtung
KR102651078B1 (ko) 2017-03-28 2024-03-22 암겐 인코포레이티드 플런저 로드 및 주사기 조립 시스템 및 방법
EP3606554A4 (de) 2017-04-05 2020-12-09 Astute Medical, Inc. Tests auf timp2 mit verbesserter leistung bei biologischen proben
JP7200134B2 (ja) 2017-06-08 2023-01-06 アムジエン・インコーポレーテツド トルク駆動式薬物送達デバイス
US11590294B2 (en) 2017-06-08 2023-02-28 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
JP7195276B2 (ja) 2017-06-22 2022-12-23 アムジエン・インコーポレーテツド デバイス起動による衝突/衝撃の低減
MA49461A (fr) 2017-06-23 2020-04-29 Amgen Inc Dispositif électronique d'administration de médicament comprenant un bouchon activé par un ensemble commutateur
MA49562A (fr) 2017-07-14 2020-05-20 Amgen Inc Système d'insertion-rétractation d'aiguille présentant un système à ressort en double torsion
EP3655063A1 (de) 2017-07-21 2020-05-27 Amgen Inc. Gasdurchlässiges dichtelement für arzneimittelbehälter und verfahren zur montage
US11484648B2 (en) 2017-07-25 2022-11-01 Amgen Inc. Drug delivery device with container access system and related method of assembly
MA49677A (fr) 2017-07-25 2021-04-21 Amgen Inc Dispositif d'administration de médicament avec module d'engrenage et procédé d'assemblage associé
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
WO2019036181A1 (en) 2017-08-18 2019-02-21 Amgen Inc. BODY INJECTOR WITH STERILE ADHESIVE PATCH
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
WO2019070472A1 (en) 2017-10-04 2019-04-11 Amgen Inc. FLOW ADAPTER FOR MEDICATION DELIVERY DEVICE
CN111132711B (zh) 2017-10-06 2022-07-01 安进公司 带有联锁组件的药物递送装置及相关组装方法
MA50348A (fr) 2017-10-09 2020-08-19 Amgen Inc Dispositif d'administration de médicament comprenant un ensemble d'entraînement et procédé d'assemblage associé
WO2019090086A1 (en) 2017-11-03 2019-05-09 Amgen Inc. Systems and approaches for sterilizing a drug delivery device
IL273664B1 (en) 2017-11-06 2026-02-01 Amgen Inc Full-fledged assemblies and related methods
US20200261648A1 (en) 2017-11-06 2020-08-20 Amgen Inc. Drug delivery device with placement and flow sensing
IL319987A (en) 2017-11-10 2025-06-01 Amgen Inc Plungers for drug delivery devices
SG11202003004RA (en) 2017-11-16 2020-04-29 Amgen Inc Door latch mechanism for drug delivery device
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
WO2020023451A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
WO2020023220A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation
CA3103681A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
EP3829692A1 (de) 2018-07-31 2021-06-09 Amgen Inc. Flüssigkeitsweganordnungen für wirkstofffreisetzungsvorrichtung
EP3856284A1 (de) 2018-09-24 2021-08-04 Amgen Inc. Interventionelle dosiersysteme und verfahren
MA53718A (fr) 2018-09-28 2022-01-05 Amgen Inc Ensemble d'activation d'échappement de fil de muscle pour un dispositif d'administration de médicament
MX2021003492A (es) 2018-10-02 2021-06-18 Amgen Inc Sistemas de inyeccion para la administracion de farmacos con transmision de fuerza interna.
JP7547325B2 (ja) 2018-10-05 2024-09-09 アムジエン・インコーポレーテツド 投薬量インジケータを有する薬物送達デバイス
AU2019359801B2 (en) 2018-10-15 2025-01-02 Amgen Inc. Platform assembly process for drug delivery device
SG11202103800RA (en) 2018-10-15 2021-05-28 Amgen Inc Drug delivery device having damping mechanism
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
MA54057A (fr) 2018-11-01 2022-02-09 Amgen Inc Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament
ES3010833T3 (en) 2018-11-01 2025-04-04 Amgen Inc Drug delivery devices with partial drug delivery member retraction
AU2020263289B2 (en) 2019-04-24 2025-05-22 Amgen Inc. Syringe sterilization verification assemblies and methods
MX2022002149A (es) 2019-08-23 2022-03-17 Amgen Inc Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados.
MX2023013640A (es) 2021-05-21 2023-11-30 Amgen Inc Metodo de optimizacion de una receta de llenado para un contenedor de medicamento.
WO2026030152A1 (en) 2024-07-29 2026-02-05 Amgen Inc. System and method for assessing transferability of a fill recipe

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2726981C2 (de) * 1977-06-15 1984-11-22 Fried. Krupp Gmbh, 4300 Essen Vorrichtung zur Zeitmessung zwischen Impulsen
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
EP0189784B1 (de) 1985-01-18 1989-11-08 G.D. Searle & Co. Menschlicher, natürlicher Collagenaseninhibitor
ATE219776T1 (de) * 1989-03-21 2002-07-15 Us Secretary United States Dep Matrizenmetalloproteinase-inhibitor-peptide
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
RU2212411C2 (ru) 1989-10-16 2003-09-20 Эмджен Инк. Полипептид, обладающий гемопоэтической биологической активностью фактора стволовых клеток (варианты), днк (варианты), экспрессирующий вектор (варианты), фармацевтическая композиция для гемопоэтической терапии, способ получения полипептида и способ его использования (варианты)
ES2093699T3 (es) * 1990-01-25 1997-01-01 Childrens Hosp Medical Center Metodo y composiciones para inhibir la angiogenesis.
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Also Published As

Publication number Publication date
DK0648838T3 (da) 2003-08-25
US7842788B2 (en) 2010-11-30
HK1055977A1 (en) 2004-01-30
US20030143693A1 (en) 2003-07-31
IL162152A (en) 2008-11-03
US20060286085A1 (en) 2006-12-21
EP0648838B1 (de) 2003-05-02
SI1319669T1 (sl) 2009-02-28
ZA947781B (en) 1995-05-17
EP0648838A1 (de) 1995-04-19
EP2011875A1 (de) 2009-01-07
US7071317B2 (en) 2006-07-04
DE69432581T2 (de) 2004-04-08
US20100010201A1 (en) 2010-01-14
PT648838E (pt) 2003-08-29
IL111171A (en) 2006-07-05
EP1319669B1 (de) 2008-10-29
ES2194852T3 (es) 2003-12-01
WO1995009918A1 (en) 1995-04-13
US6562596B1 (en) 2003-05-13
DE69435162D1 (de) 2008-12-11
IL111171A0 (en) 1994-12-29
IL162152A0 (en) 2005-11-20
DE69432581D1 (de) 2003-06-05
HK1009287A1 (en) 1999-05-28
IL191890A0 (en) 2009-05-04
EP1319669A3 (de) 2003-10-01
US6683155B1 (en) 2004-01-27
AU7928194A (en) 1995-05-01
DK1319669T3 (da) 2009-02-09
PT1319669E (pt) 2009-01-07
EP1319669A2 (de) 2003-06-18
ES2315438T3 (es) 2009-04-01
ATE412749T1 (de) 2008-11-15
US7435719B2 (en) 2008-10-14
SI0648838T1 (en) 2003-08-31

Similar Documents

Publication Publication Date Title
DE69432581D1 (de) Gewebeinhibitor für Metalloproteasen Type 3 (TIMP-3)
BG101835A (bg) Нови дипептидни амидини и използването им като инхибитори на тромбин
ATE277081T1 (de) Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
FR2712286B1 (fr) Nouveaux N-mercaptoalkyl alcanediamines et leur utilisation.
DE59310329D1 (de) Neue Sulfonamide
BE896299A (fr) Instrument d'agrafage chirurgical et cartouche utilisee pour cet instrument
DE58900119D1 (de) Chirurgisches instrument zum einsetzen von hueftpfannen-prothesen.
DE3141647A1 (de) Chirugisches instrument zum anlegen von klammern
ATE194593T1 (de) 3-(3,4-dioxyphenyl)-pyrrolidine als inhibitonen der typ iv - phosphodiesterase zur behandlung von entzündungskrankheiten
EP0471756A4 (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
DE69407272D1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
PT88275A (pt) Processo para a preparacao de composicoes farmaceuticas contendo 5-amino ou amino substituido-1,2,3-triazois uteis como agentes antiproliferativos
ATE407677T1 (de) Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung
ES2127181T3 (es) 11-beta-aril-gona-4,9-dien-3-onas.
ES2073391T3 (es) Metodo y composiciones terapeuticas para el tratamiento de trastornos de perdidas de sangre.
ATE107165T1 (de) Verwendung von macrolactonen als antiallergica.
DK207384D0 (da) Anvendelse af difunktionelle acrylsyre-og methacrylsyreestere til fremstilling af haerdelige knogle-cementer
ATE114115T1 (de) Verwendung von 5,6-dihydro-dibenz(b,e>azepin-6,11-dion-11-oxim n zur herstellungvon antiretroviralen mitteln.
DE69003323D1 (de) Flüssige zubereitung für intraokulare perfusion.
ATE63049T1 (de) Instrumente zum chirurgischen ersetzen von ligamenten.
DK189285D0 (da) (6,11-dihydro-11-oxodibenz(b,e)oxepinyl)-pentancarboxylsyrer, deres fremstilling og anvendelse
KR890002824U (ko) 논두렁용 블럭
IT8420322A0 (it) Composizioni leganti e refrattarie, nonche' metodi per la loro utilizzazione e fabbricazione.
TR22570A (tr) Derinin seri olarak tabaklan masina mahsus usul
IT8921855A0 (it) Dispositivo per eseguire l'asportazione chirurgica di segmenti di organi, per esempio segmenti epatici.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0648838

Country of ref document: EP