IL162152A0 - Tissue inhibitor metalloproteinase type three (timp-3) composition and methods - Google Patents

Tissue inhibitor metalloproteinase type three (timp-3) composition and methods

Info

Publication number
IL162152A0
IL162152A0 IL16215204A IL16215204A IL162152A0 IL 162152 A0 IL162152 A0 IL 162152A0 IL 16215204 A IL16215204 A IL 16215204A IL 16215204 A IL16215204 A IL 16215204A IL 162152 A0 IL162152 A0 IL 162152A0
Authority
IL
Israel
Prior art keywords
timp
methods
composition
tissue inhibitor
metalloproteinase type
Prior art date
Application number
IL16215204A
Other languages
English (en)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22462365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL162152(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL162152A0 publication Critical patent/IL162152A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL16215204A 1993-10-06 2004-05-24 Tissue inhibitor metalloproteinase type three (timp-3) composition and methods IL162152A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/134,231 US6562596B1 (en) 1993-10-06 1993-10-06 Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Publications (1)

Publication Number Publication Date
IL162152A0 true IL162152A0 (en) 2005-11-20

Family

ID=22462365

Family Applications (4)

Application Number Title Priority Date Filing Date
IL162152A IL162152A (en) 1993-10-06 1994-10-04 Type 3 tissue teleportase inhibitor and preparations containing it
IL111171A IL111171A (en) 1993-10-06 1994-10-04 DNA sequence encoding tissue tissue of a human metabolizing protein metabolite (3-TIMP) recombinant
IL16215204A IL162152A0 (en) 1993-10-06 2004-05-24 Tissue inhibitor metalloproteinase type three (timp-3) composition and methods
IL191890A IL191890A0 (en) 1993-10-06 2008-06-02 Tissue inhibitor metalloproteinase type three (timp-3) and compositions thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL162152A IL162152A (en) 1993-10-06 1994-10-04 Type 3 tissue teleportase inhibitor and preparations containing it
IL111171A IL111171A (en) 1993-10-06 1994-10-04 DNA sequence encoding tissue tissue of a human metabolizing protein metabolite (3-TIMP) recombinant

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL191890A IL191890A0 (en) 1993-10-06 2008-06-02 Tissue inhibitor metalloproteinase type three (timp-3) and compositions thereof

Country Status (13)

Country Link
US (5) US6562596B1 (xx)
EP (3) EP2011875A1 (xx)
AT (2) ATE239079T1 (xx)
AU (1) AU7928194A (xx)
DE (2) DE69432581T2 (xx)
DK (2) DK1319669T3 (xx)
ES (2) ES2194852T3 (xx)
HK (2) HK1009287A1 (xx)
IL (4) IL162152A (xx)
PT (2) PT1319669E (xx)
SI (2) SI0648838T1 (xx)
WO (1) WO1995009918A1 (xx)
ZA (1) ZA947781B (xx)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
DE19524720A1 (de) * 1995-07-12 1997-01-16 Hoechst Ag Zellspezifische Gentherapie mit Hilfe eines neuen Promotors für den "Tissue Inhibitor of Metalloproteinasn-3"
GB2318732A (en) * 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
WO2000056283A1 (en) * 1999-03-24 2000-09-28 The B.F.Goodrich Company Inhibition of matrix metalloproteinases with polymers and pharmaceutical applications thereof
GB9921418D0 (en) * 1999-09-11 1999-11-10 Univ Sheffield Cell transfection
AU2094101A (en) * 1999-12-13 2001-06-18 Duanqing Pei Leukolysin/mmp25/mt6-mmp
EP1251174A4 (en) * 2000-01-19 2003-05-02 Dnavec Research Inc USE OF A PARAMYXOVIRUS VECTOR FOR GENTE TRANSFER IN BLOOD VESSELS
US6562955B2 (en) * 2000-03-17 2003-05-13 Tosoh Corporation Oligonucleotides for detection of Vibrio parahaemolyticus and detection method for Vibrio parahaemolyticus using the same oligonucleotides
GB0015761D0 (en) * 2000-06-27 2000-08-16 Univ Bristol Polypeptide
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
DE10102784A1 (de) * 2001-01-22 2002-08-01 Henkel Kgaa Kosmetische oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes
ATE494000T1 (de) * 2002-03-08 2011-01-15 Max Planck Gesellschaft Verwendung von egfr transaktivierungsinhibitoren für menschlichen krebs
AUPS282002A0 (en) * 2002-06-06 2002-06-27 Gropep Limited Metalloproteinase inhibitors
EP1527175B1 (en) * 2002-06-24 2009-05-27 Exiqon A/S Methods and systems for detection and isolation of a nucleotide sequence
US7060795B2 (en) * 2002-12-19 2006-06-13 Kimberly-Clark Worldwide, Inc. Wound care compositions
US7183256B2 (en) 2003-03-21 2007-02-27 Cleveland Clinic Foundation TIMP3 as VEGF inhibitor
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
EP1660661A2 (en) 2003-08-08 2006-05-31 Arriva Pharmaceuticals, Inc. Methods of protein production in yeast
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
EP1737499A4 (en) 2004-03-09 2009-07-22 Arriva Pharmaceuticals Inc TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE BY INHALATION OF LOW DOSES OF A PROTEASE HEMMER
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
US9163076B2 (en) * 2005-03-01 2015-10-20 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
US20090318342A1 (en) * 2005-07-29 2009-12-24 Imperial Innovations Limited Compounds
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
EP2136831B1 (en) 2007-03-02 2012-09-12 The Cleveland Clinic Foundation Anti-angiogenic peptides
WO2011014671A1 (en) * 2009-07-31 2011-02-03 Amgen Inc. Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
US8710014B2 (en) * 2010-10-08 2014-04-29 Proteapex Therapeutics Llc Compositions and methods for inhibition of MMP13:MMP-substrate interactions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
CN103619879A (zh) 2010-12-01 2014-03-05 奥尔德生物控股有限责任公司 抗ngf组合物及其用途
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9434944B2 (en) 2011-08-31 2016-09-06 University Of Zurich Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis
GB2501611B (en) 2012-02-21 2015-03-04 Cytonics Corp Alpha-2-macroglobulin compositions and therapeutic uses
JP2016513666A (ja) * 2013-03-14 2016-05-16 アムジエン・インコーポレーテツド 組織メタロプロテイナーゼ阻害物質３型（ｔｉｍｐ−３）の変異体、組成物、及び方法
US9879091B2 (en) * 2013-08-07 2018-01-30 Astute Medical, Inc. Assays for TIMP2 having improved performance in biological samples
US9352021B2 (en) 2013-08-28 2016-05-31 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
EP3046937A4 (en) * 2013-09-18 2017-04-26 James Cook University Modified anti-inflammatory proteins and method of use
WO2015039188A1 (en) * 2013-09-18 2015-03-26 James Cook University Anti-inflammatory proteins and methods of use
EP3060281B1 (en) 2013-10-24 2019-01-30 Amgen Inc. Drug delivery system with temperature-sensitive control
SG11201602876WA (en) 2013-10-24 2016-05-30 Amgen Inc Injector and method of assembly
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
US10722655B2 (en) 2014-05-07 2020-07-28 Amgen Inc. Autoinjector with shock reducing elements
CN106470716B (zh) 2014-06-03 2020-07-17 安姆根有限公司 可控制药物递送系统和使用方法
WO2016025850A1 (en) 2014-08-15 2016-02-18 Amgen Inc. Pericardial drug delivery device and method of use
CA2956726C (en) 2014-08-27 2023-06-06 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
CA2957960C (en) 2014-10-14 2023-08-22 Amgen, Inc. Drug injection device with visual and audible indicators
EP3233159B1 (en) 2014-12-19 2020-03-04 Amgen Inc. Drug delivery device with live button or user interface field
ES2898469T3 (es) 2014-12-19 2022-03-07 Amgen Inc Dispositivo de administración de medicamentos con sensor de proximidad
JP6484345B2 (ja) 2015-02-17 2019-03-20 アムジエン・インコーポレーテツド 固定及び／または戻りが真空によって支援された薬物送達装置
US11806509B2 (en) 2015-02-27 2023-11-07 Amgen Inc. Drug delivery device having a needle guard mechanism with a turnable threshold of resistance to needle guard movement
US10343884B2 (en) 2015-07-10 2019-07-09 E. & J. Gallo Winery System and method for dispensing a beverage
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
US11351308B2 (en) 2015-12-09 2022-06-07 Amgen Inc. Auto-injector with signaling cap
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
EP4035711A1 (en) 2016-03-15 2022-08-03 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
US10988284B2 (en) 2016-05-13 2021-04-27 Amgen Inc. Vial sleeve assembly
EP3458988B1 (en) 2016-05-16 2023-10-18 Amgen Inc. Data encryption in medical devices with limited computational capability
EP3465124A1 (en) 2016-06-03 2019-04-10 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
EP3478342A1 (en) 2016-07-01 2019-05-08 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
US20190328965A1 (en) 2016-08-17 2019-10-31 Amgen Inc. Drug delivery device with placement detection
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
AU2018210301A1 (en) 2017-01-17 2019-08-01 Amgen Inc. Injection devices and related methods of use and assembly
MX2019009625A (es) 2017-02-17 2019-10-09 Amgen Inc Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje.
US11369736B2 (en) 2017-02-17 2022-06-28 Amgen Inc. Cannula insertion and retraction mechanisms
WO2018165143A1 (en) 2017-03-06 2018-09-13 Amgen Inc. Drug delivery device with activation prevention feature
EP3592402A1 (en) 2017-03-07 2020-01-15 Amgen Inc. Needle insertion by overpressure
MX2019010671A (es) 2017-03-09 2019-10-21 Amgen Inc Mecanismo de insercion para dispositivo de administracion de farmacos.
BR112019020053B1 (pt) 2017-03-28 2023-10-10 Amgen Inc Máquina para acoplar uma haste de êmbolo a um conjunto de seringa e método de utilização da referida máquina
EP3606554A4 (en) 2017-04-05 2020-12-09 Astute Medical, Inc. ASSAYS FOR TIMP2 WITH IMPROVED EFFICIENCY IN BIOLOGICAL SAMPLES
US11904143B2 (en) 2017-06-08 2024-02-20 Amgen Inc. Torque driven drug delivery device
AU2018280054B2 (en) 2017-06-08 2023-07-13 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
CA3063920A1 (en) 2017-06-22 2018-12-27 Amgen Inc. Device activation impact/shock reduction
US11395880B2 (en) 2017-06-23 2022-07-26 Amgen Inc. Electronic drug delivery device
MA49562A (fr) 2017-07-14 2020-05-20 Amgen Inc Système d'insertion-rétractation d'aiguille présentant un système à ressort en double torsion
EP3655063A1 (en) 2017-07-21 2020-05-27 Amgen Inc. Gas permeable sealing member for drug container and methods of assembly
EP4085942A1 (en) 2017-07-25 2022-11-09 Amgen Inc. Drug delivery device with gear module and related method of assembly
US11484648B2 (en) 2017-07-25 2022-11-01 Amgen Inc. Drug delivery device with container access system and related method of assembly
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
EP3668567A1 (en) 2017-08-18 2020-06-24 Amgen Inc. Wearable injector with sterile adhesive patch
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
MA50611A (fr) 2017-10-04 2020-08-12 Amgen Inc Adaptateur d'écoulement destiné à un dispositif d'administration de médicament
WO2019070552A1 (en) 2017-10-06 2019-04-11 Amgen Inc. DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD
US11464903B2 (en) 2017-10-09 2022-10-11 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
EP3703778A1 (en) 2017-11-03 2020-09-09 Amgen Inc. System and approaches for sterilizing a drug delivery device
US20200338271A1 (en) 2017-11-06 2020-10-29 Amgen Inc. Fill-finish assemblies and related methods
CA3079197A1 (en) 2017-11-06 2019-05-09 Amgen Inc. Drug delivery device with placement and flow sensing
CN116832271A (zh) 2017-11-10 2023-10-03 安进公司 用于药物递送装置的柱塞
MX2020004996A (es) 2017-11-16 2020-08-27 Amgen Inc Un mecanismo de pestillo de puerta para un dispositivo de administracion de farmacos.
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
US20210260279A1 (en) 2018-07-24 2021-08-26 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
WO2020023451A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
MA53379A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
US20210228797A1 (en) 2018-07-31 2021-07-29 Amgen Inc. Fluid path assembly for a drug delivery device
AU2019347710A1 (en) 2018-09-24 2021-02-04 Amgen Inc. Interventional dosing systems and methods
CA3110371A1 (en) 2018-09-28 2020-04-02 Amgen Inc. Muscle wire escapement activation assembly for a drug delivery device
MA53815A (fr) 2018-10-02 2022-01-05 Amgen Inc Systèmes d'injection pour administration de médicament avec transmission de force interne
US20210338936A1 (en) 2018-10-05 2021-11-04 Amgen Inc. Drug delivery device having dose indicator
US20200114082A1 (en) 2018-10-15 2020-04-16 Amgen Inc. Drug delivery device having damping mechanism
TW202031306A (zh) 2018-10-15 2020-09-01 美商安進公司 用於藥物遞送裝置之平台組裝方法
WO2020091981A1 (en) 2018-11-01 2020-05-07 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
WO2020091956A1 (en) 2018-11-01 2020-05-07 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
AU2020263289A1 (en) 2019-04-24 2021-09-16 Amgen Inc. Syringe sterilization verification assemblies and methods
US20220273887A1 (en) 2019-08-23 2022-09-01 Amgen Inc. Drug delivery device with configurable needle shield engagement components and related methods
EP4341161A1 (en) 2021-05-21 2024-03-27 Amgen Inc. Method of optimizing a filling recipe for a drug container

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2726981C2 (de) * 1977-06-15 1984-11-22 Fried. Krupp Gmbh, 4300 Essen Vorrichtung zur Zeitmessung zwischen Impulsen
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
DE3666826D1 (en) 1985-01-18 1989-12-14 Searle & Co Human natural inhibitor of collagenases
DE69033982T2 (de) * 1989-03-21 2002-10-24 Us Health Matrizenmetalloproteinase-inhibitor-peptide
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
RU2212411C2 (ru) 1989-10-16 2003-09-20 Эмджен Инк. Полипептид, обладающий гемопоэтической биологической активностью фактора стволовых клеток (варианты), днк (варианты), экспрессирующий вектор (варианты), фармацевтическая композиция для гемопоэтической терапии, способ получения полипептида и способ его использования (варианты)
ES2093699T3 (es) * 1990-01-25 1997-01-01 Childrens Hosp Medical Center Metodo y composiciones para inhibir la angiogenesis.
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods

Also Published As

Publication number Publication date
DK1319669T3 (da) 2009-02-09
EP1319669A2 (en) 2003-06-18
US6562596B1 (en) 2003-05-13
HK1009287A1 (en) 1999-05-28
ES2315438T3 (es) 2009-04-01
WO1995009918A1 (en) 1995-04-13
DK0648838T3 (da) 2003-08-25
US20100010201A1 (en) 2010-01-14
HK1055977A1 (en) 2004-01-30
EP2011875A1 (en) 2009-01-07
IL111171A (en) 2006-07-05
DE69435162D1 (de) 2008-12-11
US7071317B2 (en) 2006-07-04
EP1319669A3 (en) 2003-10-01
IL191890A0 (en) 2009-05-04
IL162152A (en) 2008-11-03
ZA947781B (en) 1995-05-17
AU7928194A (en) 1995-05-01
EP1319669B1 (en) 2008-10-29
US20030143693A1 (en) 2003-07-31
ATE239079T1 (de) 2003-05-15
DE69432581D1 (de) 2003-06-05
US7842788B2 (en) 2010-11-30
ES2194852T3 (es) 2003-12-01
PT648838E (pt) 2003-08-29
EP0648838B1 (en) 2003-05-02
EP0648838A1 (en) 1995-04-19
US6683155B1 (en) 2004-01-27
SI1319669T1 (sl) 2009-02-28
US20060286085A1 (en) 2006-12-21
IL111171A0 (en) 1994-12-29
PT1319669E (pt) 2009-01-07
DE69432581T2 (de) 2004-04-08
ATE412749T1 (de) 2008-11-15
SI0648838T1 (en) 2003-08-31
US7435719B2 (en) 2008-10-14

Similar Documents

Publication Publication Date Title
IL162152A0 (en) Tissue inhibitor metalloproteinase type three (timp-3) composition and methods
MX9706069A (es) Nuevos inhibidores de la trombina.
ATE529444T1 (de) Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
CA2135575A1 (fr) Composition cosmetique contenant en tant qu'agent reducteur un n-mercapto-alkyl alcanediamide ou l'un de ses sels cosmetiquement acceptable
EP0528858A4 (en) Inhibitors of dipeptidyl-aminopeptidase type iv
HU9303458D0 (en) Process for producing sulfonamides and pharmaceutical preparations containing them
MX9603831A (es) Agentes antitromboticos.
BG102425A (en) (methylsulphonyl)phenyl-2-(5h)-furanons as cyclooxygenase-2-inhibitors
AU2843689A (en) 2-(2-hydroxy-3-phenoxypropylamino) ethylphenoxymethyl compounds
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
EP0471756A4 (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof
ATE407677T1 (de) Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung
CA2130900A1 (en) Therapeutic domains of von willebrand factor
IL116231A (en) Dipeptide p-amidinobenzylamides with n-terminal sulfonyl or aminosulfonyl radicals as thrombin inhibitors
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.
EP0266993A3 (en) Method and therapeutic compositions for the treatment of bleeding disorders
IL85189A (en) Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
AP9701142A0 (en) 4,4-(Disubstituted) cyclohexan-1-ols monomers and related compounds.
MX9704035A (es) 1,1-dioxidos de 2-(fosfiniloximetil)-1,2,5-tiadiazolidin-3-ona substituidos y composiciones y metodo de uso de los mismos.
ZA9510878B (en) 4,4-(Disubstituted)cyclohexan-1-ols monomers and related compounds
TW218872B (xx)
IE882042L (en) Composition for treatment of pulmonary hypertension