|
AT275583B
(de)
|
1964-03-04 |
1969-10-27 |
Plasser Bahnbaumasch Franz |
Profilfreie Maschine zum Reinigen des Eisenbahnbettungsschotters
|
|
BR6915369D0
(pt)
|
1969-02-27 |
1973-03-13 |
Bayer Ag |
Emprego de inibidores biologicos de proteases para conservacao de orgaos tecidos e alimentos
|
|
US3691016A
(en)
|
1970-04-17 |
1972-09-12 |
Monsanto Co |
Process for the preparation of insoluble enzymes
|
|
CA1023287A
(en)
|
1972-12-08 |
1977-12-27 |
Boehringer Mannheim G.M.B.H. |
Process for the preparation of carrier-bound proteins
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
DE2619246A1
(de)
|
1976-04-30 |
1977-11-10 |
Bayer Ag |
Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
|
|
US4195128A
(en)
|
1976-05-03 |
1980-03-25 |
Bayer Aktiengesellschaft |
Polymeric carrier bound ligands
|
|
DE2654124A1
(de)
|
1976-11-29 |
1978-06-01 |
Bayer Ag |
Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel
|
|
US4330440A
(en)
|
1977-02-08 |
1982-05-18 |
Development Finance Corporation Of New Zealand |
Activated matrix and method of activation
|
|
CA1093991A
(en)
|
1977-02-17 |
1981-01-20 |
Hideo Hirohara |
Enzyme immobilization with pullulan gel
|
|
CA1113397A
(en)
*
|
1977-11-09 |
1981-12-01 |
Peter F.R. Lunn |
Aqueous persulphate and percarbonate composition for bleaching hair
|
|
US4229537A
(en)
|
1978-02-09 |
1980-10-21 |
New York University |
Preparation of trichloro-s-triazine activated supports for coupling ligands
|
|
AT359653B
(de)
|
1979-02-15 |
1980-11-25 |
Immuno Ag |
Verfahren zur herstellung eines gewebekleb- stoffes
|
|
US4299537A
(en)
*
|
1979-06-19 |
1981-11-10 |
Evans Frederick C |
Interlinked variable-pitch blades for windmills and turbines
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4634665A
(en)
|
1980-02-25 |
1987-01-06 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
AU560584B2
(en)
|
1983-07-28 |
1987-04-09 |
Bayer Aktiengesellschaft |
Homologues of aprotinin
|
|
US4657893A
(en)
|
1984-05-09 |
1987-04-14 |
Syntex (U.S.A.) Inc. |
4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
|
|
US4845242A
(en)
|
1987-04-28 |
1989-07-04 |
Georgia Tech Research Corporation |
Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
|
|
US4609725A
(en)
|
1984-10-09 |
1986-09-02 |
Merck & Co., Inc. |
Cardiac atrial peptides
|
|
US4931385A
(en)
*
|
1985-06-24 |
1990-06-05 |
Hygeia Sciences, Incorporated |
Enzyme immunoassays and immunologic reagents
|
|
US5444156A
(en)
*
|
1985-07-12 |
1995-08-22 |
Temple University-Of The Commonwealth System Of Higher Education |
Monoclonal antibodies to human plasma prekallikrein
|
|
JPH0623113B2
(ja)
|
1986-01-31 |
1994-03-30 |
浩 前田 |
癌性胸・腹水貯留抑制剤
|
|
EP0255011A3
(en)
|
1986-07-29 |
1988-11-23 |
Miles Inc. |
Human inter-alpha-trypsin inhibitor gene
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
DE3752253T2
(de)
|
1986-11-17 |
1999-05-27 |
Scios Inc |
Rekombiniertes Alzheimer Amyloid-Protein.
|
|
US5187153A
(en)
|
1986-11-17 |
1993-02-16 |
Scios Nova Inc. |
Methods of treatment using Alzheimer's amyloid polypeptide derivatives
|
|
EP0285123A3
(en)
|
1987-04-03 |
1989-02-01 |
Stabra AG |
A method for complete mutagenesis of nucleic acids
|
|
US4966852A
(en)
|
1987-07-23 |
1990-10-30 |
Monsanto Company |
DNA clone of human tissue factor inhibitor
|
|
US5106833A
(en)
|
1987-07-23 |
1992-04-21 |
Washington University |
Coagulation inhibitors
|
|
IL87172A
(en)
|
1987-07-23 |
1994-12-29 |
Univ Washington |
A method of inhibiting the isolation of a purer tissue factor
|
|
GB2208511A
(en)
*
|
1987-08-07 |
1989-04-05 |
Bayer Ag |
Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
|
|
DK225488D0
(da)
|
1988-04-26 |
1988-04-26 |
Novo Industri As |
Polypeptid
|
|
IL87171A
(en)
|
1987-11-23 |
1995-08-31 |
Monsanto Co |
ANDC of human tissue factor inhibitor
|
|
US5663143A
(en)
|
1988-09-02 |
1997-09-02 |
Dyax Corp. |
Engineered human-derived kunitz domains that inhibit human neutrophil elastase
|
|
US7078383B2
(en)
|
1988-09-02 |
2006-07-18 |
Dyax Corp. |
ITI-D1 Kunitz domain mutants as HNE inhibitors
|
|
EP1541682A3
(en)
|
1988-09-02 |
2005-07-06 |
Dyax Corp. |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5372933A
(en)
*
|
1988-10-03 |
1994-12-13 |
The Scripps Research Institute |
Polypeptides that mimic receptor-induced binding sites, and methods of using same
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0401508B1
(de)
|
1989-05-13 |
1994-11-23 |
Bayer Ag |
Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
|
|
US5378614A
(en)
|
1989-08-18 |
1995-01-03 |
Novo Nordisk A/S |
Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
|
|
DK408089D0
(da)
|
1989-08-18 |
1989-08-18 |
Novo Nordisk As |
Proteiner
|
|
US5278285A
(en)
|
1990-02-01 |
1994-01-11 |
Bayer Aktiengesellschaft |
Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology
|
|
US5583107A
(en)
|
1990-09-04 |
1996-12-10 |
Cor Therapeutics, Inc. |
Agents affecting thrombosis and hemostasis
|
|
US5278144A
(en)
|
1990-09-04 |
1994-01-11 |
Cor Therapeutics, Inc. |
Antithrombosis agents
|
|
IL99585A0
(en)
|
1990-10-01 |
1992-08-18 |
Novo Nordisk As |
Aprotinin analogues,their production and pharmaceutical compositions containing them
|
|
US5409895A
(en)
|
1990-11-13 |
1995-04-25 |
Mochida Pharmaceutical Co., Ltd. |
Protease inhibitory polypeptides derived from urinary trypsin inhibitor and compositions thereof
|
|
US20030223977A1
(en)
|
1991-03-01 |
2003-12-04 |
Ley Arthur Charles |
Kunitz domain mutants as cathepsin G inhibitors
|
|
US5166133A
(en)
|
1991-04-17 |
1992-11-24 |
Cetus Corporation |
Method for inhibing adhesion of white blood cells to endothelial cells
|
|
LU91067I2
(fr)
|
1991-06-14 |
2004-04-02 |
Genentech Inc |
Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
|
|
AU3061092A
(en)
|
1991-10-31 |
1993-06-07 |
Salk Institute Biotechnology/Industrial Associates, Inc., The |
Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
|
|
IL104325A
(en)
|
1992-01-07 |
2000-10-31 |
Novo Nordisk As |
Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
|
|
IL104314A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
|
IL104324A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
IL104326A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
IL104327A0
(en)
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Variant of human kunitz-type protease inhibitor
|
|
US5212091A
(en)
|
1992-03-02 |
1993-05-18 |
Monsanto Company |
Method of producing tissue factor pathway inhibitor
|
|
US6063764A
(en)
|
1992-06-01 |
2000-05-16 |
Washington University & Chiron Corp. |
Method for using lipoprotein associated coagulation inhibitor to treat sepsis
|
|
EP0651766A4
(en)
*
|
1992-07-13 |
1996-07-31 |
Corvas Int Inc |
INHIBITORS OF FACTOR Xa, DERIVED FROM THE INHIBITOR OF THE PANCREATIC TRYPSON FROM BEEF.
|
|
US5436153A
(en)
*
|
1992-12-02 |
1995-07-25 |
Sprecher; Cindy A. |
Human amyloid protein precursor homolog and Kunitz-type inhibitor
|
|
WO1994012637A2
(en)
|
1992-12-02 |
1994-06-09 |
Zymogenetics, Inc. |
Novel human amyloid protein precursor homologue and kunitz-type inhibitors
|
|
US5426224A
(en)
|
1993-03-18 |
1995-06-20 |
The University Of North Carolina At Chapel Hill |
Mammalian DNA topoisomerase II inhibitor and method
|
|
CA2170030A1
(en)
*
|
1993-09-14 |
1995-03-23 |
Robert A. Lazarus |
Pharmaceutical compositions containing ecotin and homologs thereof
|
|
US5455338A
(en)
|
1993-11-05 |
1995-10-03 |
Zymogenetics, Inc. |
DNA encoding novel human kunitz-type inhibitors and methods relating thereto
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5759548A
(en)
|
1993-11-30 |
1998-06-02 |
Lxr Biotechnology Inc. |
Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US6057287A
(en)
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
|
EP0739355B1
(en)
|
1994-01-11 |
2004-09-08 |
Dyax Corporation |
Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof
|
|
ATE529444T1
(de)
|
1994-01-11 |
2011-11-15 |
Dyax Corp |
Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
|
|
US5795954A
(en)
*
|
1994-03-04 |
1998-08-18 |
Genentech, Inc. |
Factor VIIa inhibitors from Kunitz domain proteins
|
|
HU221311B1
(en)
|
1994-06-02 |
2002-09-28 |
Merrell Pharma Inc |
Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
|
|
AU707762B2
(en)
|
1994-08-05 |
1999-07-22 |
Novartis Vaccines And Diagnostics, Inc. |
Production of tissue factor pathway inhibitor
|
|
US5589359A
(en)
|
1994-08-05 |
1996-12-31 |
Chiron Corporation |
Chimeric proteins
|
|
US5648331A
(en)
|
1994-08-26 |
1997-07-15 |
G.D. Searle & Co. |
Method of inhibiting tissue ischemia and reperfusion injury
|
|
ES2276396T3
(es)
*
|
1994-10-18 |
2007-06-16 |
Dendreon Corporation |
Proteinas anticoagulantes e inhibidores de la serina proteasa extraidos de nematodos.
|
|
US6159938A
(en)
*
|
1994-11-21 |
2000-12-12 |
Cortech, Inc. |
Serine protease inhibitors comprising α-keto heterocycles
|
|
AU4467396A
(en)
*
|
1994-12-12 |
1996-07-10 |
Omeros Medical Systems, Inc. |
Irrigation solution and method for inhibition of pain, inflammation and spasm
|
|
CA2206119C
(en)
*
|
1994-12-12 |
2008-05-13 |
Omeros Medical Systems, Inc. |
Irrigation solution and method for inhibition of pain, inflammation and spasm
|
|
US5914316A
(en)
|
1994-12-16 |
1999-06-22 |
Washington University |
Method of inhibiting intimal hyperplasia
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
ES2208737T3
(es)
*
|
1995-03-10 |
2004-06-16 |
Berlex Laboratories, Inc. |
Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
|
|
US5695760A
(en)
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
US5804376A
(en)
|
1995-05-02 |
1998-09-08 |
Incyte Pharmaceuticals, Inc. |
Pancreas-derived serpin
|
|
CA2220497A1
(en)
|
1995-05-08 |
1996-11-14 |
Scios, Inc. |
Kunitz type protease inhibitors
|
|
ZA963619B
(en)
*
|
1995-05-08 |
1996-11-22 |
Scios Inc |
Protease inhibitor peptides
|
|
US5780265A
(en)
*
|
1995-06-05 |
1998-07-14 |
Genentech, Inc. |
Kunitz type plasma kallikrein inhibitors
|
|
US5786328A
(en)
*
|
1995-06-05 |
1998-07-28 |
Genentech, Inc. |
Use of kunitz type plasma kallikrein inhibitors
|
|
US6242414B1
(en)
|
1995-06-07 |
2001-06-05 |
Chiron Corporation |
Regulation of cytokine synthesis and release
|
|
US6126933A
(en)
|
1995-06-27 |
2000-10-03 |
Genetics Institute |
Methods of treating inflammatory bowel diseases by administering IL-11
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
JPH0959838A
(ja)
|
1995-08-24 |
1997-03-04 |
Kuraray Co Ltd |
紡績糸
|
|
WO1997009989A1
(en)
|
1995-09-14 |
1997-03-20 |
Lxr Biotechnology Inc. |
Compositions with anti-apoptotic activity, containing a mixture of phospholipids
|
|
WO1997010847A1
(en)
|
1995-09-21 |
1997-03-27 |
University Of Utah Research Foundation |
Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells
|
|
US5824870A
(en)
|
1995-11-06 |
1998-10-20 |
Baszczynski; Chris |
Commercial production of aprotinin in plants
|
|
US5736364A
(en)
*
|
1995-12-04 |
1998-04-07 |
Genentech, Inc. |
Factor viia inhibitors
|
|
KR100356956B1
(ko)
|
1996-03-11 |
2003-03-15 |
베이어 코오포레이숀 |
사람비쿠닌
|
|
US6013763A
(en)
*
|
1996-06-04 |
2000-01-11 |
Genentech, Inc. |
Peptide variants of protein A
|
|
JP3657700B2
(ja)
*
|
1996-06-18 |
2005-06-08 |
新日本石油化学株式会社 |
カサ高性不織布の製造方法
|
|
US5869637A
(en)
|
1996-07-22 |
1999-02-09 |
Incyte Pharmaceuticals, Inc. |
Human Kallikrein
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
US6258351B1
(en)
|
1996-11-06 |
2001-07-10 |
Shearwater Corporation |
Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
|
|
US6262233B1
(en)
|
1997-01-31 |
2001-07-17 |
Human Genome Sciences, Inc. |
Tissue factor pathway inhibitor-3
|
|
US5786238A
(en)
*
|
1997-02-13 |
1998-07-28 |
Generyal Dynamics Information Systems, Inc. |
Laminated multilayer substrates
|
|
US5962300A
(en)
|
1997-03-26 |
1999-10-05 |
Incyte Pharmaceuticals, Inc. |
Human kallikrein
|
|
AU736549B2
(en)
|
1997-05-21 |
2001-08-02 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Method for the production of non-immunogenic proteins
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
WO1999021558A2
(en)
|
1997-10-28 |
1999-05-06 |
Vivus, Inc. |
Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
DK1053019T3
(da)
|
1998-01-07 |
2004-04-13 |
Debio Rech Pharma Sa |
Nedbrydelige heterobifunktionelle polyethylenglycolacrylater og geler og konjugater afledt derfra
|
|
WO1999045964A1
(en)
|
1998-03-12 |
1999-09-16 |
Shearwater Polymers, Incorporated |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
|
WO1999048948A1
(fr)
|
1998-03-24 |
1999-09-30 |
Nof Corporation |
Derives d'oxiranne et leur procede de production
|
|
US6017723A
(en)
|
1998-03-27 |
2000-01-25 |
Long Island Jewish Medical Center |
Method for isolating inhibitors of protease activity
|
|
US6001596A
(en)
|
1998-05-07 |
1999-12-14 |
Incyte Pharmaceuticals, Inc. |
Growth-associated protease inhibitor heavy chain precursor
|
|
US6087473A
(en)
*
|
1999-05-26 |
2000-07-11 |
Zymogenetics, Inc. |
Kunitz domain polypeptide and materials and methods for making it
|
|
CA2330191A1
(en)
*
|
1998-06-03 |
1999-12-09 |
Scios, Inc. |
Protease inhibitor peptides
|
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
EP2316475B1
(en)
|
1998-08-06 |
2017-10-04 |
Mountain View Pharmaceuticals, Inc. |
Isolated tetrameric uricase
|
|
CA2342072C
(en)
|
1998-09-03 |
2005-01-11 |
Zymogenetics, Inc. |
Kunitz domain polypeptide zkun6
|
|
US7067144B2
(en)
|
1998-10-20 |
2006-06-27 |
Omeros Corporation |
Compositions and methods for systemic inhibition of cartilage degradation
|
|
US6565874B1
(en)
|
1998-10-28 |
2003-05-20 |
Atrix Laboratories |
Polymeric delivery formulations of leuprolide with improved efficacy
|
|
JP2002531089A
(ja)
|
1998-11-30 |
2002-09-24 |
イーライ・リリー・アンド・カンパニー |
赤血球産生性化合物
|
|
CN1202128C
(zh)
|
1998-12-08 |
2005-05-18 |
拜奥威神有限公司 |
修饰蛋白的免疫原性
|
|
US20030012969A1
(en)
|
1999-04-06 |
2003-01-16 |
Clark Bert Thomas |
Soluble membrane strengthened paper products
|
|
AU781734B2
(en)
|
1999-04-29 |
2005-06-09 |
Hans Medical AB |
Use of heparin-binding antagonists in the inhibition of bradykinin release
|
|
US6605316B1
(en)
|
1999-07-31 |
2003-08-12 |
The Regents Of The University Of California |
Structures and fabrication techniques for solid state electrochemical devices
|
|
US6180607B1
(en)
*
|
1999-08-05 |
2001-01-30 |
Christopher Davies |
Protein having proteinase inhibitor activity
|
|
CN1371416B
(zh)
|
1999-08-24 |
2012-10-10 |
梅达里克斯公司 |
人ctla-4抗体及其应用
|
|
EP1231943A1
(en)
|
1999-11-12 |
2002-08-21 |
Maxygen Holdings Ltd |
Interferon gamma conjugates
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
DK1259563T4
(en)
|
1999-12-22 |
2016-11-21 |
Nektar Therapeutics |
PROCEDURE FOR PREPARING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF WATER SOLUBLE POLYMERS
|
|
US6544760B2
(en)
|
1999-12-22 |
2003-04-08 |
Zymogenetics, Inc. |
Kunitz domain polypeptide Zkun11
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US20020102703A1
(en)
|
1999-12-29 |
2002-08-01 |
Sheppard Paul O. |
Kunitz domain polypeptide zkun10
|
|
GB9930882D0
(en)
*
|
1999-12-30 |
2000-02-23 |
Nps Allelix Corp |
GLP-2 formulations
|
|
AU2001249074A1
(en)
|
2000-03-13 |
2001-09-24 |
Eli Lilly And Company |
Human hepatocyte growth factor activator inhibitor homologue
|
|
WO2001079442A2
(en)
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CN1331213A
(zh)
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人大蛋白10.01和编码这种多肽的多核苷酸
|
|
DE10034357C1
(de)
|
2000-07-14 |
2001-12-13 |
Elotherm Gmbh |
Verfahren und Vorrichtung zum Härten von Flächen an Bauteilen
|
|
EP2298789B1
(en)
|
2000-09-08 |
2012-03-14 |
Schering Corporation |
Mammalian genes; related reagents and methods
|
|
EP1223972B1
(en)
|
2000-10-31 |
2003-07-23 |
Debiopharm S.A. |
Suspension of an epi-hne protein, process of preparation thereof, dry powder aerosol derived therefrom, pharmaceutical compositions containing said suspension or aerosol, and their uses
|
|
WO2002061131A2
(en)
|
2000-12-04 |
2002-08-08 |
Bristol-Myers Squibb Company |
Human single nucleotide polymorphisms
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
EP1392350A2
(en)
|
2001-05-11 |
2004-03-03 |
Aradigm Corporation |
Optimization of the molecular properties and formulation of proteins delivered by inhalation
|
|
AU2002303869B2
(en)
|
2001-05-21 |
2007-08-16 |
Novartis Ag |
Pulmonary administration of chemically modified insulin
|
|
US20040152633A1
(en)
|
2001-05-31 |
2004-08-05 |
Jorgensen Marianne Ulrich |
Kunitz-type sequences and polypeptides
|
|
WO2003006860A1
(fr)
|
2001-07-10 |
2003-01-23 |
Sankyo Seiki Mfg. Co., Ltd. |
Dispositif de commande de soupape
|
|
AU2002358921A1
(en)
|
2001-07-10 |
2003-04-28 |
Omnio Ab |
Novel drug targets for arthritis
|
|
AU2003244516A1
(en)
|
2002-02-07 |
2003-09-02 |
Novozymes Delta Limited |
Hiv inhibiting proteins
|
|
US20050222023A1
(en)
|
2002-02-07 |
2005-10-06 |
Hans-Peter Hauser |
Albumin-fused kunitz domain peptides
|
|
WO2003101941A2
(en)
|
2002-05-31 |
2003-12-11 |
Genzyme Corporation |
Alpha acyloxyacetamides for kallikrein and urokinase inhibition
|
|
ES2372978T3
(es)
*
|
2002-06-07 |
2012-01-30 |
Dyax Corp. |
Polipéptido con dominio de kunitz modificado.
|
|
US7153829B2
(en)
*
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
|
RU2296769C2
(ru)
|
2002-07-24 |
2007-04-10 |
Ф.Хоффманн-Ля Рош Аг |
Пэгилированный полипептид т20
|
|
BR0313212A
(pt)
|
2002-07-24 |
2005-06-28 |
Hoffmann La Roche |
Aditivos de ácido de polialquileno glicol
|
|
HUE042899T2
(hu)
|
2002-08-28 |
2019-07-29 |
Dyax Corp |
Eljárás szervek és szövetek tartósítására
|
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US7314613B2
(en)
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
PT1667708E
(pt)
|
2002-12-26 |
2012-09-14 |
Mountain View Pharmaceuticals |
Conjugados de interferão-beta-1b e polietileno glicol apresentando uma potência biológica in vitro aumentada
|
|
CA2512590A1
(en)
|
2003-01-07 |
2004-07-29 |
Dyax Corporation |
Kunitz domain library
|
|
PT1589949E
(pt)
|
2003-01-08 |
2008-11-06 |
Novartis Vaccines & Diagnostic |
Composições liofilizadas estabilizadas compreendendo inibidor da coagulação por factores tecidulares ou variante de inibidor da coagulação por factores tecidulares
|
|
PT1599222E
(pt)
|
2003-01-08 |
2009-06-12 |
Novartis Vaccines & Diagnostic |
Composições aquosas estabilizadas que contêm um inibidor da via do factor tecidular (tfpi) ou uma variante do inibidor da via do factor tecidular
|
|
DE10301300B4
(de)
|
2003-01-15 |
2009-07-16 |
Curacyte Chemistry Gmbh |
Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
|
|
US6989369B2
(en)
*
|
2003-02-07 |
2006-01-24 |
Dyax Corp. |
Kunitz domain peptides
|
|
WO2005003150A2
(en)
|
2003-07-02 |
2005-01-13 |
Emory University |
Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury
|
|
CA2535859A1
(en)
|
2003-08-14 |
2005-03-03 |
Dyax Corp. |
Endotheliase-2 ligands
|
|
US20050089515A1
(en)
|
2003-08-29 |
2005-04-28 |
Dyax Corp. |
Poly-pegylated protease inhibitors
|
|
CA2537113A1
(en)
|
2003-08-29 |
2005-03-10 |
Dyax Corp. |
Modified protease inhibitors
|
|
US8114123B2
(en)
|
2003-09-19 |
2012-02-14 |
St. Jude Medical, Inc. |
Apparatus and methods for tissue gathering and securing
|
|
JP2007507538A
(ja)
|
2003-10-02 |
2007-03-29 |
エラン ファーマシューティカルズ，インコーポレイテッド |
疼痛軽減方法
|
|
US20060228331A1
(en)
|
2003-10-10 |
2006-10-12 |
Novo Nordisk A/S |
IL-21 Derivatives and variants
|
|
WO2005041631A2
(en)
|
2003-10-21 |
2005-05-12 |
Dyax Corp. |
Endotheliase-1 ligands
|
|
US20070253949A1
(en)
|
2004-02-03 |
2007-11-01 |
Stefan Golz |
Diagnostics and Therapeutics for Diseases Associated with Plasma Kallikrein (KLKB1)
|
|
JP4775259B2
(ja)
|
2004-03-31 |
2011-09-21 |
味の素株式会社 |
アニリン誘導体
|
|
JP2008515774A
(ja)
|
2004-08-03 |
2008-05-15 |
ダイアックス コーポレイション |
ｈＫ１結合タンパク質
|
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
|
AU2005309722B2
(en)
|
2004-11-22 |
2011-10-20 |
Dyax Corp. |
Plasmin-inhibitory therapies
|
|
ITMI20042442A1
(it)
|
2004-12-21 |
2005-03-21 |
Aliveris S R L |
Paste alimentari con migliorate caratteristiche di digeribilita'
|
|
EP2272565A3
(en)
|
2004-12-23 |
2012-03-28 |
CSL Behring GmbH |
Prevention of thrombus formation and/or stabilization
|
|
WO2006089005A2
(en)
|
2005-02-17 |
2006-08-24 |
Bristol-Myers Squibb Company |
Combination of selective factor viia and/or xia and plasma kallikrein inhibitors
|
|
EP1858542A4
(en)
|
2005-02-24 |
2009-08-19 |
Joslin Diabetes Center Inc |
COMPOSITIONS AND METHODS FOR TREATING VASCULAR PERMEABILITY
|
|
NZ591179A
(en)
|
2005-05-04 |
2012-06-29 |
Zealand Pharma As |
Glucagon-like-peptide-2 (glp-2) analogues
|
|
US20070079096A1
(en)
|
2005-09-30 |
2007-04-05 |
Chih-Wei Chen |
Data storage unit access authorization table automatic rebuilding method and system
|
|
MXPA06011291A
(es)
|
2005-09-30 |
2007-06-08 |
9141 0720 Quebec Inc |
Dispositivo de operacion de cierre motorizado con sistema de control electronico.
|
|
AU2006332774A1
(en)
|
2005-12-29 |
2007-07-12 |
Dyax Corp. |
Protease inhibition
|
|
US7276480B1
(en)
*
|
2005-12-30 |
2007-10-02 |
Dyax Corp. |
Prevention and reduction of blood loss
|
|
US20070213275A1
(en)
*
|
2006-03-10 |
2007-09-13 |
Dyax Corp. |
Formulations for ecallantide
|
|
DK1854477T3
(en)
|
2006-03-16 |
2016-11-28 |
Dyax Corp |
Peptide inhibitors of plasma kallikrein for use in the treatment of eye disorders
|
|
US20080031426A1
(en)
|
2006-06-27 |
2008-02-07 |
Weeks Walter L |
Audio, video, and navigational law enforcement system and method
|
|
EP1873344A1
(de)
|
2006-06-30 |
2008-01-02 |
Sika Technology AG |
Mittels Silikon agedichtete Verklebung
|
|
WO2008016883A2
(en)
|
2006-07-31 |
2008-02-07 |
Activesite Pharmaceuticals, Inc. |
Inhibitors of plasma kallikrein
|
|
WO2008060764A2
(en)
|
2006-10-05 |
2008-05-22 |
Drugtech Corporation |
Topical therapies for oral mucositis and other conditions
|
|
WO2009026334A2
(en)
|
2007-08-21 |
2009-02-26 |
Genzyme Corporation |
Treatment with kallikrein inhibitors
|
|
EP2195011A4
(en)
|
2007-08-23 |
2010-12-01 |
Genzyme Corp |
TREATMENT WITH CALLICINE INHIBITORS
|
|
CA2715297A1
(en)
|
2008-02-13 |
2009-08-20 |
Dyax Corp. |
Improved methods for producing specific binding pairs
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
DE102008033095A1
(de)
|
2008-07-15 |
2010-01-28 |
Uhde Gmbh |
Vorrichtung zur Schlackeabführung aus einem Kohlevergasungsreaktor
|
|
CN102307594A
(zh)
|
2009-01-06 |
2012-01-04 |
戴埃克斯有限公司 |
用激肽释放酶抑制剂治疗粘膜炎
|
|
PT2521568T
(pt)
|
2010-01-06 |
2018-10-26 |
Dyax Corp |
Proteínas de ligação à calicreína plasmática
|
|
KR102169651B1
(ko)
|
2011-01-06 |
2020-10-23 |
다이액스 코포레이션 |
혈장 칼리크레인 결합 단백질
|
|
US8691861B2
(en)
|
2011-04-13 |
2014-04-08 |
Activesite Pharmaceuticals, Inc. |
Prodrugs of inhibitors of plasma kallikrein
|
|
DK2946206T3
(en)
|
2013-01-20 |
2019-04-15 |
Dyax Corp |
EVALUATION, ANALYSIS AND TREATMENT OF PKAL-MEDIATED DISORDERS
|
|
US10428158B2
(en)
|
2014-03-27 |
2019-10-01 |
Dyax Corp. |
Compositions and methods for treatment of diabetic macular edema
|