EA201891002A1 - Иммунологический анализ для определения расщепленного высокомолекулярного кининогена - Google Patents

Иммунологический анализ для определения расщепленного высокомолекулярного кининогена

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Publication number
EA201891002A1
EA201891002A1 EA201891002A EA201891002A EA201891002A1 EA 201891002 A1 EA201891002 A1 EA 201891002A1 EA 201891002 A EA201891002 A EA 201891002A EA 201891002 A EA201891002 A EA 201891002A EA 201891002 A1 EA201891002 A1 EA 201891002A1
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EA
Eurasian Patent Office
Prior art keywords
splitted
determination
immunological analysis
kininogen
molecular
Prior art date
Application number
EA201891002A
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English (en)
Inventor
Дэниел Дж. Секстон
Райан Фосетт
Джаня Косик
Original Assignee
Дайэкс Корп.
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Publication date
Application filed by Дайэкс Корп. filed Critical Дайэкс Корп.
Publication of EA201891002A1 publication Critical patent/EA201891002A1/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • Molecular Biology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Настоящее изобретение относится к способам иммунологического анализа для детекции расщепленного высокомолекулярного кининогена (HMWK) с высокой чувствительностью и специфичностью и выделенным антителам, специфически связывающимся с расщепленным HMWK.
EA201891002A 2015-10-19 2016-10-19 Иммунологический анализ для определения расщепленного высокомолекулярного кининогена EA201891002A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562243505P 2015-10-19 2015-10-19
US201662335311P 2016-05-12 2016-05-12
PCT/US2016/057640 WO2017070170A1 (en) 2015-10-19 2016-10-19 Immunoassay to detect cleaved high molecular weight kininogen

Publications (1)

Publication Number Publication Date
EA201891002A1 true EA201891002A1 (ru) 2018-11-30

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EA201891002A EA201891002A1 (ru) 2015-10-19 2016-10-19 Иммунологический анализ для определения расщепленного высокомолекулярного кининогена

Country Status (17)

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US (2) US10914747B2 (ru)
EP (3) EP4354146A3 (ru)
JP (3) JP6903648B2 (ru)
KR (2) KR102698737B1 (ru)
CN (2) CN113655228A (ru)
AU (2) AU2016340826C1 (ru)
BR (1) BR112018007842A2 (ru)
CA (1) CA3002747A1 (ru)
CO (1) CO2018004289A2 (ru)
DK (1) DK3365685T3 (ru)
EA (1) EA201891002A1 (ru)
ES (2) ES2857552T3 (ru)
IL (2) IL312916A (ru)
MX (2) MX2018004763A (ru)
PL (2) PL3365685T3 (ru)
PT (1) PT3365685T (ru)
WO (1) WO2017070170A1 (ru)

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WO2017070170A1 (en) 2017-04-27
EP4354146A3 (en) 2024-06-05
PL3365685T3 (pl) 2021-08-02
PL3839514T3 (pl) 2024-06-10
JP7238027B2 (ja) 2023-03-13
MX2018004763A (es) 2018-09-06
US10914747B2 (en) 2021-02-09
US20210270842A1 (en) 2021-09-02
NZ741448A (en) 2023-10-27
EP3839514B1 (en) 2023-12-13
IL258637B1 (en) 2024-06-01
JP2023078186A (ja) 2023-06-06
IL258637B2 (en) 2024-10-01
JP2021167824A (ja) 2021-10-21
AU2023200462A1 (en) 2023-03-02
CN113655228A (zh) 2021-11-16
AU2016340826A1 (en) 2018-04-26
AU2016340826C1 (en) 2023-05-04
DK3365685T3 (da) 2021-03-01
IL258637A (en) 2018-06-28
IL312916A (en) 2024-07-01
US20180306807A1 (en) 2018-10-25
CN108291917A (zh) 2018-07-17
ES2973301T3 (es) 2024-06-19
EP3365685A1 (en) 2018-08-29
AU2016340826B2 (en) 2022-11-24
CN108291917B (zh) 2021-08-27
PT3365685T (pt) 2021-03-01
CO2018004289A2 (es) 2018-11-22
EP4354146A2 (en) 2024-04-17
KR20180093897A (ko) 2018-08-22
ES2857552T3 (es) 2021-09-29
JP6903648B2 (ja) 2021-07-14
EP3365685B1 (en) 2020-11-25
EP3839514A1 (en) 2021-06-23
CA3002747A1 (en) 2017-04-27
BR112018007842A2 (pt) 2019-04-16
MX2023005689A (es) 2023-05-29
KR20240133761A (ko) 2024-09-04
KR102698737B1 (ko) 2024-08-27
JP2019502095A (ja) 2019-01-24

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