EA201692071A1 - Иммуноанализ и антитела для обнаружения хромогранина а - Google Patents
Иммуноанализ и антитела для обнаружения хромогранина аInfo
- Publication number
- EA201692071A1 EA201692071A1 EA201692071A EA201692071A EA201692071A1 EA 201692071 A1 EA201692071 A1 EA 201692071A1 EA 201692071 A EA201692071 A EA 201692071A EA 201692071 A EA201692071 A EA 201692071A EA 201692071 A1 EA201692071 A1 EA 201692071A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chromogranin
- antibodies
- antigen
- detection
- binding
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/062—Gastritis or peptic ulcer disease
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/321—Arterial hypertension
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
В заявке описан способ иммуноанализа для обнаружения хромогранина А или его фрагмента(ов), заключающийся в том, что осуществляют стадии, на которых приводят в контакт образец, который предположительно содержит хромогранин А, с первым антителом или его антигенсвязывающим фрагментом или производным, обладающим специфичностью в отношении хромогранина А, и вторым антителом или его антигенсвязывающим фрагментом или производным, обладающим специфичностью в отношении хромогранина А, в условиях, в которых может происходить образование тройного комплекса между хромогранином А и двумя антителами или их антигенсвязывающими фрагментами или производными, и проводят обнаружение связывания двух антител или их антигенсвязывающих фрагментов или производных с хромогранином А. Описаны также антитела к аминокислотным остаткам 124-144 и 280-301 хромогранина А и их применение в способе иммуноанализа.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14164809 | 2014-04-15 | ||
PCT/EP2015/058045 WO2015158701A1 (en) | 2014-04-15 | 2015-04-14 | Immunoassay and antibodies for the detection of chromogranin a |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201692071A1 true EA201692071A1 (ru) | 2017-04-28 |
EA034364B1 EA034364B1 (ru) | 2020-01-30 |
Family
ID=50543441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201692071A EA034364B1 (ru) | 2014-04-15 | 2015-04-14 | Иммуноанализ для обнаружения хромогранина а |
Country Status (9)
Country | Link |
---|---|
US (2) | US10648984B2 (ru) |
EP (2) | EP3633378A1 (ru) |
JP (2) | JP6591442B2 (ru) |
CN (2) | CN114573692B (ru) |
BR (1) | BR112016021714A2 (ru) |
DK (1) | DK3132268T3 (ru) |
EA (1) | EA034364B1 (ru) |
ES (1) | ES2764225T3 (ru) |
WO (1) | WO2015158701A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20190086419A1 (en) * | 2016-03-09 | 2019-03-21 | Cézanne S.A.S. | Chromogranin a as a marker for bladder cancer |
CN107090439B (zh) * | 2017-06-02 | 2020-05-05 | 福州迈新生物技术开发有限公司 | 一株分泌抗嗜铬素a单克隆抗体的杂交瘤细胞株及其应用 |
BR112020018828A2 (pt) * | 2018-03-16 | 2021-02-09 | Quest Diagnostics Investments Llc | métodos para detecção de cromogranina através de uma espectrometria de massa |
CN109507432A (zh) * | 2018-11-14 | 2019-03-22 | 嘉兴行健生物科技有限公司 | 一种嗜铬蛋白a检测试剂及检测参考区间及检测方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758522A (en) * | 1985-03-08 | 1988-07-19 | The Regents Of The University Of California | Immunoassay for human chromogranin A |
US6238877B1 (en) | 1997-11-05 | 2001-05-29 | Arup Institute | Method for prediction prostate cancer patients' resistance to hormonal treatment by measuring serum concentrations of chromogranin A |
FR2778744B1 (fr) * | 1998-05-14 | 2000-06-23 | Cis Bio Int | Dosage immunologique de la chromogranine a humaine (cga) anticorps, reactifs et trousses utilisables pour ce dosage |
US20050186642A1 (en) * | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
CN101377513A (zh) * | 2008-04-16 | 2009-03-04 | 北京科美东雅生物技术有限公司 | 嗜铬素a化学发光免疫分析定量测定试剂盒及其制备方法 |
WO2010146064A1 (en) * | 2009-06-16 | 2010-12-23 | B.R.A.H.M.S Gmbh | Diagnostical use of peroxiredoxin 4 |
EP2383293A1 (en) | 2010-04-28 | 2011-11-02 | Euro-diagnostica AB | Immunoassay for Chromogranin A, antibodies and kit |
US9671413B2 (en) | 2010-11-12 | 2017-06-06 | William Marsh Rice University | Prostate cancer point of care diagnostics |
JP5817838B2 (ja) * | 2011-11-02 | 2015-11-18 | ウシオ電機株式会社 | 蛍光標識抗体可変領域含有ポリペプチド複合体を用いた蛍光免疫測定方法 |
US8632971B2 (en) | 2011-11-08 | 2014-01-21 | Caldera Health Limited | Methods and materials for determining the efficacy of prostate cancer therapies |
US8658166B2 (en) | 2011-11-08 | 2014-02-25 | Caldera Health Limited | Methods and materials for the diagnosis of prostate cancers |
CN102520195B (zh) * | 2011-12-30 | 2014-07-23 | 天津市协和医药科技集团有限公司 | 一种嗜铬粒蛋白a化学发光免疫分析试剂盒及其制备方法 |
US20190086419A1 (en) * | 2016-03-09 | 2019-03-21 | Cézanne S.A.S. | Chromogranin a as a marker for bladder cancer |
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2015
- 2015-04-14 CN CN202210181051.3A patent/CN114573692B/zh active Active
- 2015-04-14 US US15/303,521 patent/US10648984B2/en active Active
- 2015-04-14 EP EP19202912.2A patent/EP3633378A1/en active Pending
- 2015-04-14 CN CN201580019631.0A patent/CN106461673A/zh active Pending
- 2015-04-14 WO PCT/EP2015/058045 patent/WO2015158701A1/en active Application Filing
- 2015-04-14 ES ES15715739T patent/ES2764225T3/es active Active
- 2015-04-14 EA EA201692071A patent/EA034364B1/ru not_active IP Right Cessation
- 2015-04-14 BR BR112016021714A patent/BR112016021714A2/pt not_active Application Discontinuation
- 2015-04-14 DK DK15715739.7T patent/DK3132268T3/da active
- 2015-04-14 JP JP2016562949A patent/JP6591442B2/ja active Active
- 2015-04-14 EP EP15715739.7A patent/EP3132268B1/en active Active
-
2019
- 2019-09-18 JP JP2019169343A patent/JP6812521B2/ja active Active
-
2020
- 2020-04-07 US US16/842,666 patent/US11719697B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3132268A1 (en) | 2017-02-22 |
EP3132268B1 (en) | 2019-10-16 |
EA034364B1 (ru) | 2020-01-30 |
US11719697B2 (en) | 2023-08-08 |
JP6812521B2 (ja) | 2021-01-13 |
CN106461673A (zh) | 2017-02-22 |
JP6591442B2 (ja) | 2019-10-16 |
WO2015158701A1 (en) | 2015-10-22 |
US10648984B2 (en) | 2020-05-12 |
EP3633378A1 (en) | 2020-04-08 |
CN114573692B (zh) | 2024-05-28 |
JP2017514128A (ja) | 2017-06-01 |
BR112016021714A2 (pt) | 2017-10-17 |
US20200348304A1 (en) | 2020-11-05 |
JP2020016660A (ja) | 2020-01-30 |
ES2764225T3 (es) | 2020-06-02 |
CN114573692A (zh) | 2022-06-03 |
US20170122945A1 (en) | 2017-05-04 |
DK3132268T3 (da) | 2020-01-02 |
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Legal Events
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |