ECSP088081A - Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente - Google Patents

Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente

Info

Publication number
ECSP088081A
ECSP088081A EC2008008081A ECSP088081A ECSP088081A EC SP088081 A ECSP088081 A EC SP088081A EC 2008008081 A EC2008008081 A EC 2008008081A EC SP088081 A ECSP088081 A EC SP088081A EC SP088081 A ECSP088081 A EC SP088081A
Authority
EC
Ecuador
Prior art keywords
therapeutic antibody
detection
diana
ancient
absence
Prior art date
Application number
EC2008008081A
Other languages
English (en)
Inventor
Helmut Lenz
Werner Scheuer
Martina Thier
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP088081A publication Critical patent/ECSP088081A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase

Abstract

La presente invención está relacionada con el campo de los anticuerpos terapéuticos. La invención especialmente está relacionada con un método para la detección del antígeno diana de un anticuerpo terapéutico en una muestra que consiste en los siguientes pasos: a) proporcionar la muestra a analizar, b) incubar dicha muestra con dicho anticuerpo terapéutico bajo las condiciones apropiadas para unir dicho anticuerpo terapéutico a dicho antígeno diana, de manera que se forma un complejo de antígeno diana-anticuerpo terapéutico y c) detectar el complejo formado en (b).
EC2008008081A 2005-07-06 2008-01-04 Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente ECSP088081A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05014618 2005-07-06
EP06004447 2006-03-06

Publications (1)

Publication Number Publication Date
ECSP088081A true ECSP088081A (es) 2008-02-20

Family

ID=36922121

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008081A ECSP088081A (es) 2005-07-06 2008-01-04 Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente

Country Status (19)

Country Link
US (1) US20070009976A1 (es)
EP (2) EP1902315A1 (es)
JP (1) JP2008545145A (es)
KR (1) KR20080016939A (es)
AR (1) AR053948A1 (es)
AU (1) AU2006265275A1 (es)
BR (1) BRPI0612591A2 (es)
CA (1) CA2613187A1 (es)
CR (1) CR9635A (es)
EC (1) ECSP088081A (es)
IL (1) IL188317A0 (es)
MA (1) MA29730B1 (es)
MX (1) MX2008000277A (es)
MY (1) MY157955A (es)
NO (1) NO20076662L (es)
NZ (1) NZ564471A (es)
RU (1) RU2008103608A (es)
TW (1) TWI312864B (es)
WO (1) WO2007003420A1 (es)

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KR20030007640A (ko) 2000-05-19 2003-01-23 제넨테크, 인크. ＥｒｂＢ 길항제에 의한 암 치료요법에 대한 효과적인반응의 가능성을 개선시키기 위한 유전자 검출 분석
BRPI0513681A (pt) * 2004-07-22 2008-05-13 Genentech Inc composição que compreendem anticorpo her2, método, formulações farmacêuticas, polipeptìdeo, anticorpo e método de tratamento de cáncer
WO2006039486A2 (en) 2004-10-01 2006-04-13 The Board Of Trustees Of The Leland Stanford Junior University Imaging arrangements and methods therefor
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
RU2404806C2 (ru) 2005-02-23 2010-11-27 Дженентек, Инк. Продление времени до прогрессирования заболевания или продолжительности жизни у онкологических больных с применением ингибиторов димеризации her
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
US8248515B2 (en) 2006-02-07 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Variable imaging arrangements and methods therefor
US8358354B2 (en) 2009-01-26 2013-01-22 The Board Of Trustees Of The Leland Stanford Junior University Correction of optical abberations
CL2008000614A1 (es) 2007-03-02 2008-09-05 Genentech Inc F Hoffmann La Ro Metodo para tratar un paciente con un tipo de cancer que expresa el receptor her3 a un nivel bajo mediante la administracion de un inhibidor de la dimerizacion de her.
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
CN117018187A (zh) 2011-10-14 2023-11-10 霍夫曼-拉罗奇有限公司 Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品
KR101327542B1 (ko) * 2012-03-15 2013-11-08 광주과학기술원 양자점 기반의 경쟁 면역분석법 및 다중 유세포 분석법을 이용한 시료 중 오염물질의 검출 방법
AU2012232949B2 (en) * 2012-09-28 2014-07-03 Willowtree Holdings Pty Ltd Temporary bulkhead
BR112015024926A2 (pt) 2013-04-16 2017-10-10 Genentech Inc composições, artigo de fabricação, métodos para tratar um paciente com câncer, para avaliar uma composição, para avaliar a atividade biológica, para produzir uma composição e para avaliar a fragmentação de uma composição e variante de pertuzumabe
CN106163558A (zh) 2014-04-25 2016-11-23 豪夫迈·罗氏有限公司 用曲妥珠单抗‑mcc‑dm1和帕妥珠单抗治疗早期乳腺癌的方法
WO2016196373A2 (en) 2015-05-30 2016-12-08 Genentech, Inc. Methods of treating her2-positive metastatic breast cancer
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
CA3046092A1 (en) 2016-12-28 2018-07-05 Genentech, Inc. Treatment of advanced her2 expressing cancer
KR20200113292A (ko) 2017-01-17 2020-10-06 제넨테크, 인크. 피하 her2 항체 제형
US11077189B2 (en) 2017-03-02 2021-08-03 Genentech Inc. Adjuvant treatment of HER2-positive breast cancer
CN110536969A (zh) 2017-04-24 2019-12-03 豪夫迈·罗氏有限公司 跨膜或近膜域中的erbb2/her2突变

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Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
ATE255131T1 (de) * 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
AU4025193A (en) 1992-04-08 1993-11-18 Cetus Oncology Corporation Humanized C-erbB-2 specific antibodies
IL129354A0 (en) 1996-10-18 2000-02-17 Genentech Inc Anti-ErbB2 antibodies
EP2131198B1 (en) 2001-09-20 2013-03-27 Board of Regents, The University of Texas System Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays
PT1585966E (pt) * 2002-07-15 2012-02-20 Hoffmann La Roche Tratamento de cancro com o anticorpo anti-erbb2 rhumab 2c4

Also Published As

Publication number Publication date
AU2006265275A1 (en) 2007-01-11
RU2008103608A (ru) 2009-08-20
NO20076662L (no) 2008-04-03
EP2194380A3 (en) 2010-07-14
EP1902315A1 (en) 2008-03-26
KR20080016939A (ko) 2008-02-22
CR9635A (es) 2008-02-20
IL188317A0 (en) 2008-04-13
MA29730B1 (fr) 2008-09-01
JP2008545145A (ja) 2008-12-11
MX2008000277A (es) 2008-03-24
US20070009976A1 (en) 2007-01-11
BRPI0612591A2 (pt) 2010-11-23
EP2194380A2 (en) 2010-06-09
NZ564471A (en) 2010-04-30
TWI312864B (en) 2009-08-01
TW200741203A (en) 2007-11-01
WO2007003420A1 (en) 2007-01-11
AR053948A1 (es) 2007-05-23
CA2613187A1 (en) 2007-01-11
MY157955A (en) 2016-08-30

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