EA201691168A1 - Способы исследования бета-глюкана - Google Patents

Способы исследования бета-глюкана

Info

Publication number
EA201691168A1
EA201691168A1 EA201691168A EA201691168A EA201691168A1 EA 201691168 A1 EA201691168 A1 EA 201691168A1 EA 201691168 A EA201691168 A EA 201691168A EA 201691168 A EA201691168 A EA 201691168A EA 201691168 A1 EA201691168 A1 EA 201691168A1
Authority
EA
Eurasian Patent Office
Prior art keywords
subject
biomarker
sample
oea
glucan
Prior art date
Application number
EA201691168A
Other languages
English (en)
Inventor
Нандита Боуз
Мэри А. Энтонисэми
Кит Б. Горден
Ричард Уолш
Майкл Э. Дэниелсон
Питер Маймонис
Original Assignee
Байотера, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байотера, Инк. filed Critical Байотера, Инк.
Publication of EA201691168A1 publication Critical patent/EA201691168A1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961—Plant cells or fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/24—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar beta-D-Glucans, i.e. having beta 1,n (n=3,4,6) linkages between saccharide units, e.g. xanthan
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее раскрытие представляет в одном аспекте способ анализа образца из субъекта на предмет биомаркера, указывающего на иммунный ответ субъекта на β-глюкан. Как правило, способ включает получение биологического образца от субъекта, анализ образца на предмет биомаркерного анти-β-глюканового антитела по сравнению со стандартом сравнения, вычисление значения в относительных единицах антитела (ОЕА) для анти-β-глюканового антитела в образце и идентификацию субъекта как положительного в отношении биомаркера, если значение ОЕА превышает заранее определенное значение ОЕА для биомаркерного анти-β-глюканового антитела.
EA201691168A 2013-12-05 2014-12-01 Способы исследования бета-глюкана EA201691168A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361912275P 2013-12-05 2013-12-05
US201462005335P 2014-05-30 2014-05-30
PCT/US2014/067944 WO2015084732A1 (en) 2013-12-05 2014-12-01 β-GLUCAN ASSAY METHODS

Publications (1)

Publication Number Publication Date
EA201691168A1 true EA201691168A1 (ru) 2016-11-30

Family

ID=53274006

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691168A EA201691168A1 (ru) 2013-12-05 2014-12-01 Способы исследования бета-глюкана

Country Status (12)

Country Link
US (3) US9885726B2 (ru)
EP (1) EP3077816B1 (ru)
JP (1) JP6673829B2 (ru)
CN (1) CN106170698A (ru)
AU (1) AU2014357446B2 (ru)
CA (1) CA2932192C (ru)
EA (1) EA201691168A1 (ru)
ES (1) ES2874057T3 (ru)
IL (1) IL245913A0 (ru)
MX (1) MX2016007148A (ru)
NZ (1) NZ720608A (ru)
WO (1) WO2015084732A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3373006A1 (en) * 2012-04-30 2018-09-12 Biothera, Inc. Beta-glucan immunotherapeutic methods
WO2018156888A1 (en) * 2017-02-24 2018-08-30 Biothera Pharmaceuticals, Inc. Beta glucan immunopharmacodynamics
CN112424602B (zh) * 2018-07-27 2024-09-06 积水医疗株式会社 生物样品中(1→3)-β-D-葡聚糖的免疫分析方法、(1→3)-β-D-葡聚糖分析试剂盒以及(1→3)-β-D-葡聚糖免疫分析方法中使用的生物样品碱性预处理溶液
WO2020184409A1 (ja) * 2019-03-08 2020-09-17 積水メディカル株式会社 生体試料中のβ－Ｄ－グルカンの免疫学的分析方法、及びβ－Ｄ－グルカン分析用キット

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6084092A (en) 1997-01-31 2000-07-04 The Collaborative Group, Ltd. β(1-3)-glucan diagnostic assays
GB0211118D0 (en) * 2002-05-15 2002-06-26 Polonelli Luciano Vaccines
US8883760B2 (en) * 2002-09-04 2014-11-11 University Of Louisville Research Foundation, Inc. Cancer therapy using beta glucan and antibodies
SE0203116D0 (sv) * 2002-10-21 2002-10-21 Tremedic Internat Ab Antibodies reactive with beta-glucons
US8450079B2 (en) * 2003-10-31 2013-05-28 Immunetics, Inc. Method for detecting bacteria
JP4666284B2 (ja) * 2005-11-30 2011-04-06 味の素株式会社 グルカン感受性予測方法、グルカン感受性増強剤及びそのスクリーニング方法
JP4795037B2 (ja) * 2006-02-01 2011-10-19 財団法人 神戸市地域医療振興財団 川崎病の判定方法及びそのためのキット
WO2007146416A2 (en) 2006-06-15 2007-12-21 Biopolymer Engineering, Inc. Dba Biothera, Inc. Glucan preparations
AU2013203785B2 (en) * 2006-11-06 2016-11-17 Immunexcite, Inc. Immunomodulating compositions and methods of use thereof
JP4979467B2 (ja) * 2006-12-05 2012-07-18 尚仁 大野 抗β−グルカン抗体測定方法と測定キット
JP5054425B2 (ja) * 2007-05-07 2012-10-24 尚仁 大野 抗β−１，６−グルカン・モノクローナル抗体
MY150220A (en) 2007-05-08 2013-12-31 Biothera Inc Particulate-soluble glucan preparation
US8617823B2 (en) * 2008-04-29 2013-12-31 Immunexcite, Inc. Immunomodulating compositions and methods of use thereof
JP5686308B2 (ja) * 2009-02-20 2015-03-18 国立大学法人広島大学 βグルカンの濃度測定方法および濃度測定用キット
BRPI1013671A2 (pt) * 2009-03-06 2016-04-26 Mochida Pharm Co Ltd método para o diagnóstico de endometriose e kit de diagnóstico para endometriose
ES2655725T3 (es) 2009-03-17 2018-02-21 Wako Pure Chemical Industries, Ltd. Método para medir beta-glucano, y proteína de unión a beta-glucano para su uso en el método
JP5487393B2 (ja) * 2009-03-31 2014-05-07 静岡県 ＥＬＩＳＡ法を用いたヒト血清中の抗原特異的なＩｇＧ抗体力価測定の標準化法
JP5633721B2 (ja) * 2009-10-30 2014-12-03 国立大学法人徳島大学 乳幼児のアレルギー発症を予測するためのデータを提供する方法
US20140228543A1 (en) 2011-05-06 2014-08-14 Biothera, Inc. MODIFIED AND DERIVATIZED ß-GLUCAN COMPOUNDS, COMPOSITIONS, AND METHODS
FI123866B (en) * 2012-02-03 2013-11-29 Thermo Fisher Scientific Oy Method for the determination of beta-D-glucan content
EP3373006A1 (en) * 2012-04-30 2018-09-12 Biothera, Inc. Beta-glucan immunotherapeutic methods
CN102866255B (zh) 2012-09-13 2014-12-24 莫水晶 一种人体液真菌(1,3)-β-D葡聚糖检测试剂盒及其应用方法
CN103235116B (zh) * 2013-04-13 2015-06-03 福州大学 一种抗体标记信号或核酸探针标记信号放大的方法

Also Published As

Publication number Publication date
US20190064179A1 (en) 2019-02-28
CN106170698A (zh) 2016-11-30
CA2932192A1 (en) 2015-06-11
EP3077816A1 (en) 2016-10-12
IL245913A0 (en) 2016-07-31
MX2016007148A (es) 2016-12-07
AU2014357446B2 (en) 2020-05-07
WO2015084732A1 (en) 2015-06-11
CA2932192C (en) 2020-10-06
NZ720608A (en) 2022-11-25
ES2874057T3 (es) 2021-11-04
US9885726B2 (en) 2018-02-06
US20180128836A1 (en) 2018-05-10
EP3077816B1 (en) 2021-03-24
US20160305955A1 (en) 2016-10-20
JP6673829B2 (ja) 2020-03-25
EP3077816A4 (en) 2017-06-21
US10114027B2 (en) 2018-10-30
AU2014357446A1 (en) 2016-06-16
JP2017501399A (ja) 2017-01-12

Similar Documents

Publication Publication Date Title
EA201590027A1 (ru) Способы детекции заболеваний или состояний
GB2519906A (en) Methods and systems for detecting biological components
MX366275B (es) Metodos para detectar y medir la agregacion.
EA201270020A1 (ru) Определение риска развития атеросклеротической болезни сердца
WO2015094995A3 (en) Gene signature biomarkers of tumor response to pd-1 antagonists
WO2014201516A3 (en) Biomarker identification
BR112016019836A2 (pt) método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito
MX2021006791A (es) Metodos y composiciones para detectar proteinas mal plegadas.
EA201391245A1 (ru) Интеррогативные клеточные анализы и их применение
BR112014025520A2 (pt) método para estimar características de uma formação
WO2015094996A3 (en) Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
EA201500080A1 (ru) Способ in vitro диагностирования и мониторинга рака
EA201690213A1 (ru) Композиции и способ лечения связанных с комплементом состояний
EA201790769A1 (ru) Определение уровней гликозаминогликанов методом масс-спектрометрии
EA201690731A1 (ru) Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах
MX2016001719A (es) Metodos y equipos para predecir el riesgo de tener una enfermedad o evento cardiovascular.
EA201691682A1 (ru) Способы анализирования редких циркулирующих в крови клеток
EA201691168A1 (ru) Способы исследования бета-глюкана
EA201700208A1 (ru) Способ и устройство для обнаружения малярии
MX363679B (es) Metodo para diagnosticar cancer.
MX2015004419A (es) Deteccion de analito y determinacion de concentracion de analito mediante uso de perlas magnetizables.
MX2017009752A (es) Adn huesped como biomarcador de la enfermedad de crohn.
MX2016012278A (es) Deteccion temprana de preeclampsia.
GB201206323D0 (en) Methods and arrays for use in the same
MX2015013993A (es) Procedimientos y series para su uso en los mismos.