BR112016023046A8 - kit compreendendo anticorpos e agentes redutores - Google Patents
kit compreendendo anticorpos e agentes redutoresInfo
- Publication number
- BR112016023046A8 BR112016023046A8 BR112016023046A BR112016023046A BR112016023046A8 BR 112016023046 A8 BR112016023046 A8 BR 112016023046A8 BR 112016023046 A BR112016023046 A BR 112016023046A BR 112016023046 A BR112016023046 A BR 112016023046A BR 112016023046 A8 BR112016023046 A8 BR 112016023046A8
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- kit
- reducing agents
- detecting
- methods
- Prior art date
Links
- 239000003638 chemical reducing agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Dispersion Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
kit compreendendo anticorpos e agentes redutores o presente documento refere-se a métodos para detecção e quantificação de cadeias pesadas e leves de imunoglobulina usando técnicas de espectrometria de massa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461975524P | 2014-04-04 | 2014-04-04 | |
PCT/US2015/024379 WO2015154052A1 (en) | 2014-04-04 | 2015-04-03 | Isotyping immunoglobulins using accurate molecular mass |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016023046A8 true BR112016023046A8 (pt) | 2021-05-11 |
Family
ID=54241354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016023046A BR112016023046A8 (pt) | 2014-04-04 | 2015-04-03 | kit compreendendo anticorpos e agentes redutores |
Country Status (8)
Country | Link |
---|---|
US (4) | US10267806B2 (pt) |
EP (1) | EP3126826B1 (pt) |
JP (2) | JP6759104B2 (pt) |
AU (2) | AU2015240454B2 (pt) |
BR (1) | BR112016023046A8 (pt) |
CA (1) | CA2944767C (pt) |
ES (1) | ES2861600T3 (pt) |
WO (1) | WO2015154052A1 (pt) |
Families Citing this family (24)
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DK3729958T3 (da) * | 2013-03-15 | 2023-08-07 | Mayo Found Medical Education & Res | Identificering og overvågning af monoklonale immunoglobuliner ved hjælp af molekylmasse |
CA2944767C (en) | 2014-04-04 | 2022-07-12 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
US10690676B2 (en) | 2014-07-29 | 2020-06-23 | Mayo Roundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by LC-MS/MS |
WO2017053932A1 (en) | 2015-09-24 | 2017-03-30 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
CN116333124A (zh) * | 2016-01-29 | 2023-06-27 | 索伦托药业有限公司 | 与pd-l1结合的抗原结合蛋白 |
GB201603291D0 (en) * | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
CN109863395B (zh) * | 2016-09-07 | 2023-05-23 | 梅约医学教育与研究基金会 | 分子量法鉴定和监测裂解免疫球蛋白 |
GB2567793B (en) * | 2017-04-13 | 2023-03-22 | Micromass Ltd | A method of fragmenting and charge reducing biomolecules |
GB201708262D0 (en) * | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
US20200271663A1 (en) | 2017-09-13 | 2020-08-27 | Mayo Foundation For Medical Education And Research | Identification and monitoring of acid hydrolysis products of immunoglobulin heavy chains |
WO2019055632A1 (en) * | 2017-09-13 | 2019-03-21 | Mayo Foundation For Medical Education And Research | IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN CHAINS J |
EP3681528A4 (en) | 2017-09-13 | 2021-07-21 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF THE APOPTOSIS INHIBITOR OF MACROPHAGES |
GB201808529D0 (en) * | 2018-05-24 | 2018-07-11 | Binding Site Group Ltd | Identification of immunoglobulins usong mass spectrometry |
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GB201915946D0 (en) | 2019-11-01 | 2019-12-18 | Binding Site Group Ltd | Quantitation of immunoglobulins i n mass spectrometry |
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GB202016822D0 (en) | 2020-10-23 | 2020-12-09 | Binding Site Group Ltd | Quantitation of immunoglobulins in mass spectrometry |
CN112326860B (zh) * | 2020-10-30 | 2022-12-09 | 淄博高新技术产业开发区生物医药研究院 | 同时检测原料药或制剂中1,4-二氯丁烷和1-氯-4-羟基丁烷遗传毒性杂质的方法 |
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CN115684606B (zh) * | 2022-10-21 | 2023-11-28 | 南方医科大学珠江医院 | 一种m蛋白检测的方法 |
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2015
- 2015-04-03 CA CA2944767A patent/CA2944767C/en active Active
- 2015-04-03 WO PCT/US2015/024379 patent/WO2015154052A1/en active Application Filing
- 2015-04-03 EP EP15772546.6A patent/EP3126826B1/en active Active
- 2015-04-03 US US15/301,633 patent/US10267806B2/en active Active
- 2015-04-03 JP JP2016560650A patent/JP6759104B2/ja active Active
- 2015-04-03 ES ES15772546T patent/ES2861600T3/es active Active
- 2015-04-03 BR BR112016023046A patent/BR112016023046A8/pt unknown
- 2015-04-03 AU AU2015240454A patent/AU2015240454B2/en active Active
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2019
- 2019-03-08 US US16/297,340 patent/US10753945B2/en active Active
- 2019-11-21 AU AU2019268150A patent/AU2019268150B2/en active Active
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2020
- 2020-07-16 US US16/930,790 patent/US11604196B2/en active Active
- 2020-09-02 JP JP2020147252A patent/JP6951527B2/ja active Active
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AU2019268150A1 (en) | 2019-12-12 |
AU2015240454A1 (en) | 2016-11-24 |
CA2944767C (en) | 2022-07-12 |
US20200341003A1 (en) | 2020-10-29 |
WO2015154052A1 (en) | 2015-10-08 |
JP2021021734A (ja) | 2021-02-18 |
AU2015240454B2 (en) | 2019-08-22 |
JP6951527B2 (ja) | 2021-10-20 |
EP3126826B1 (en) | 2020-12-16 |
EP3126826A4 (en) | 2019-01-02 |
ES2861600T3 (es) | 2021-10-06 |
US10753945B2 (en) | 2020-08-25 |
CA2944767A1 (en) | 2015-10-08 |
US20200003784A1 (en) | 2020-01-02 |
EP3126826A1 (en) | 2017-02-08 |
US10267806B2 (en) | 2019-04-23 |
JP2017513004A (ja) | 2017-05-25 |
US20230243845A1 (en) | 2023-08-03 |
US11604196B2 (en) | 2023-03-14 |
US20170023584A1 (en) | 2017-01-26 |
JP6759104B2 (ja) | 2020-09-23 |
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