BR112017011932A8 - Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso - Google Patents

Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso

Info

Publication number
BR112017011932A8
BR112017011932A8 BR112017011932A BR112017011932A BR112017011932A8 BR 112017011932 A8 BR112017011932 A8 BR 112017011932A8 BR 112017011932 A BR112017011932 A BR 112017011932A BR 112017011932 A BR112017011932 A BR 112017011932A BR 112017011932 A8 BR112017011932 A8 BR 112017011932A8
Authority
BR
Brazil
Prior art keywords
methods
coupled receptor
protein coupled
antibodies targeted
antibodies
Prior art date
Application number
BR112017011932A
Other languages
English (en)
Other versions
BR112017011932A2 (pt
Inventor
J Brentjens Renier
L Smith Eric
Liu Cheng
Original Assignee
Memorial Sloan Kettering Cancer Center
Eureka Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center, Eureka Therapeutics Inc filed Critical Memorial Sloan Kettering Cancer Center
Publication of BR112017011932A2 publication Critical patent/BR112017011932A2/pt
Publication of BR112017011932A8 publication Critical patent/BR112017011932A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

Abstract

ANTICORPOS DIRECIONADOS A RECEPTOR ACOPLADO A PROTEÍNA G E MÉTODOS DE USO. A matéria atualmente revelada fornece anticorpos que se ligam a GPRC5D e métodos de uso dos mesmos.
BR112017011932A 2014-12-05 2015-12-04 Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso BR112017011932A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088228P 2014-12-05 2014-12-05
US62/088,228 2014-12-05
PCT/US2015/064122 WO2016090329A2 (en) 2014-12-05 2015-12-04 Antibodies targeting g-protein coupled receptor and methods of use

Publications (2)

Publication Number Publication Date
BR112017011932A2 BR112017011932A2 (pt) 2018-01-16
BR112017011932A8 true BR112017011932A8 (pt) 2022-11-08

Family

ID=56092679

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017011932A BR112017011932A8 (pt) 2014-12-05 2015-12-04 Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso

Country Status (17)

Country Link
US (4) US10590196B2 (pt)
EP (1) EP3227324A4 (pt)
JP (5) JP6753851B2 (pt)
KR (2) KR102602417B1 (pt)
CN (3) CN113429482A (pt)
AU (3) AU2015357535B2 (pt)
BR (1) BR112017011932A8 (pt)
CA (1) CA2969886A1 (pt)
HK (1) HK1243955A1 (pt)
IL (3) IL307767A (pt)
MX (3) MX2017007247A (pt)
MY (1) MY195115A (pt)
PH (1) PH12017501039A1 (pt)
RU (2) RU2020120613A (pt)
SA (1) SA517381664B1 (pt)
SG (2) SG10201913937QA (pt)
WO (1) WO2016090329A2 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL310130A (en) 2014-12-05 2024-03-01 Memorial Sloan Kettering Cancer Center G-protein receptor-directed chimeric antigen receptors and their use
TWI781108B (zh) * 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
WO2018147245A1 (ja) * 2017-02-07 2018-08-16 第一三共株式会社 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子
IL310182A (en) 2017-04-26 2024-03-01 Eureka Therapeutics Inc ׂ A Delaware Corp Structures of chimeric antibody/T-cell receptor and uses thereof
MX2020001491A (es) 2017-08-09 2020-08-06 Juno Therapeutics Inc Metodos y composiciones para preparar celulas geneticamente modificadas.
ES2959953T3 (es) 2017-08-09 2024-02-29 Juno Therapeutics Inc Métodos para producir composiciones celulares genéticamente modificadas y composiciones relacionadas
EP3679370A1 (en) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Methods of identifying cellular attributes related to outcomes associated with cell therapy
US20210132042A1 (en) 2017-11-01 2021-05-06 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
MA50859A (fr) 2017-11-01 2020-09-09 Celgene Corp Procédé pour la production d'une composition de lymphocytes t
WO2019089848A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
AU2018360599A1 (en) 2017-11-01 2020-05-07 Juno Therapeutics, Inc. Process for generating therapeutic compositions of engineered cells
US20210198372A1 (en) 2017-12-01 2021-07-01 Juno Therapeutics, Inc. Methods for dosing and for modulation of genetically engineered cells
US20200384025A1 (en) 2017-12-08 2020-12-10 Juno Therapeutics, Inc. Process for producing a composition of engineered t cells
CN112203680A (zh) 2017-12-08 2021-01-08 朱诺治疗学股份有限公司 用于细胞疗法的表型标记和相关方法
EP3720949A1 (en) 2017-12-08 2020-10-14 Juno Therapeutics, Inc. Serum-free media formulation for culturing cells and methods of use thereof
TWI829667B (zh) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 結合gprc5d之抗體
US11827672B2 (en) * 2018-03-30 2023-11-28 Eureka Therapeutics, Inc. Constructs trageting CD22 and uses thereof
US20210060071A1 (en) * 2018-04-27 2021-03-04 The Trustees Of The University Of Pennsylvania Chimeric Antigen Receptor T Regulatory Cells for the Treatment of Atherosclerosis
MX2021001523A (es) 2018-08-09 2021-05-27 Juno Therapeutics Inc Procesos para generar células modificadas y composiciones de las mismas.
US20210230671A1 (en) 2018-08-09 2021-07-29 Juno Therapeutics, Inc. Methods for assessing integrated nucleic acids
WO2020089343A1 (en) 2018-10-31 2020-05-07 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
WO2020092854A2 (en) 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d)
US20220088070A1 (en) 2018-11-30 2022-03-24 Juno Therapeutics, Inc. Methods for treatment using adoptive cell therapy
KR20220016474A (ko) 2019-05-01 2022-02-09 주노 쎄러퓨티크스 인코퍼레이티드 변형된 ｃｄ247 유전자 자리로부터 키메라 수용체를 발현하는 세포, 관련 폴리뉴클레오타이드 및 방법
SG11202111360YA (en) 2019-05-01 2021-11-29 Juno Therapeutics Inc Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
MA56206A (fr) 2019-06-12 2022-04-20 Juno Therapeutics Inc Combinaison thérapeutique d'une thérapie cytotoxique à médiation cellulaire et d'un inhibiteur d'une protéine de la famille bcl2 pro-survie
CA3141926A1 (en) * 2019-06-14 2020-12-17 Dana-Farber Cancer Institute, Inc. Antibodies against muc1 and methods of use thereof
EP3994270A1 (en) 2019-07-02 2022-05-11 Fred Hutchinson Cancer Research Center Recombinant ad35 vectors and related gene therapy improvements
JP2022543551A (ja) 2019-07-31 2022-10-13 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｇｐｒｃ５ｄに結合する抗体
KR20220028035A (ko) 2019-07-31 2022-03-08 에프. 호프만-라 로슈 아게 Gprc5d에 결합하는 항체
US20220298222A1 (en) 2019-08-22 2022-09-22 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
CA3159380A1 (en) 2019-10-30 2021-05-06 Juno Therapeutics Gmbh Cell selection and/or stimulation devices and methods of use
EP4069742A1 (en) * 2019-12-06 2022-10-12 Juno Therapeutics, Inc. Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods
KR20220146480A (ko) 2020-01-28 2022-11-01 주노 쎄러퓨티크스 인코퍼레이티드 Ｔ 세포 형질도입 방법
JP2023528215A (ja) 2020-05-13 2023-07-04 ジュノー セラピューティクス インコーポレイテッド 臨床応答に関連する特徴量の特定方法およびその使用
KR20230042283A (ko) 2020-06-26 2023-03-28 주노 테라퓨틱스 게엠베하 재조합 수용체를 조건부로 발현하는 조작된 ｔ 세포, 관련된 폴리뉴클레오티드 및 방법
WO2022098787A1 (en) 2020-11-04 2022-05-12 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
WO2022148370A1 (en) * 2021-01-05 2022-07-14 Lanova Medicines Development Co., Ltd. Anti-gprc5d monoclonal antibodies and uses thereof
CR20230374A (es) * 2021-01-05 2023-10-05 Lanova Medicines Dev Co Ltd Anticuerpos monoclonales anti-gprc5d y usos de los mismos
IL305144A (en) 2021-02-16 2023-10-01 Janssen Pharmaceutica Nv Trispecific antibodies targeting BCMA, GPRC5D and CD3
KR20230165771A (ko) 2021-03-03 2023-12-05 주노 쎄러퓨티크스 인코퍼레이티드 T 세포 요법 및 dgk 억제제의 조합
CA3208944A1 (en) 2021-03-22 2022-09-29 Edith NALBANDIAN Method to assess potency of viral vector particles
WO2022204070A1 (en) 2021-03-22 2022-09-29 Juno Therapeutics, Inc. Methods of determining potency of a therapeutic cell composition
WO2022234009A2 (en) 2021-05-06 2022-11-10 Juno Therapeutics Gmbh Methods for stimulating and transducing t cells
WO2022247804A1 (zh) * 2021-05-23 2022-12-01 上海祥耀生物科技有限责任公司 抗gprc5d抗体、其制备方法与用途
TW202334222A (zh) * 2021-11-05 2023-09-01 大陸商正大天晴藥業集團股份有限公司 結合gprc5d的抗體及其用途
CN116375867A (zh) * 2021-12-31 2023-07-04 康源博创生物科技(北京)有限公司 抗gprc5d抗体及其应用
WO2023131328A1 (zh) * 2022-01-10 2023-07-13 南京维立志博生物科技有限公司 一种抗体及其用途
WO2023147515A1 (en) 2022-01-28 2023-08-03 Juno Therapeutics, Inc. Methods of manufacturing cellular compositions
WO2023213969A1 (en) 2022-05-05 2023-11-09 Juno Therapeutics Gmbh Viral-binding protein and related reagents, articles, and methods of use
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023230581A1 (en) 2022-05-25 2023-11-30 Celgene Corporation Methods of manufacturing t cell therapies
WO2023227062A1 (en) * 2022-05-27 2023-11-30 Antengene (Hangzhou) Biologics Co., Ltd. Novel anti-gprc5d antibodies, bispecific antigen binding molecules that bind gprc5d and cd3, and uses thereof
WO2024007020A1 (en) 2022-06-30 2024-01-04 Indapta Therapeutics, Inc. Combination of engineered natural killer (nk) cells and antibody therapy and related methods
WO2024017326A1 (zh) * 2022-07-21 2024-01-25 山东先声生物制药有限公司 抗gprc5d纳米抗体及其应用
US20240041929A1 (en) 2022-08-05 2024-02-08 Juno Therapeutics, Inc. Chimeric antigen receptors specific for gprc5d and bcma
WO2024054944A1 (en) 2022-09-08 2024-03-14 Juno Therapeutics, Inc. Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
AU4426296A (en) * 1994-08-11 1996-03-07 Takeda Chemical Industries Ltd. G protein coupled receptor protein, production, and use thereof
CN1824777A (zh) * 1999-09-24 2006-08-30 索尔瓦药物有限公司 新的人g蛋白偶联受体
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
WO2003016553A2 (en) * 2001-08-20 2003-02-27 Genentech, Inc. Gpcr-like retinoic acid-induced gene 1 protein and nucleic acid
EP1468694A1 (en) * 2001-12-27 2004-10-20 Sumitomo Pharmaceuticals Company, Limited Remedies for anorexia or lifestyle-related diseases and method of screening the same
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
CA2510315C (en) * 2002-12-20 2014-01-28 Protein Design Labs, Inc. Antibodies against gpr64 and uses thereof
MXPA05008521A (es) * 2003-02-13 2005-10-20 Pharmacia Corp Anticuerpos a c-met para el tratamiento de canceres.
WO2005019258A2 (en) * 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP5362563B2 (ja) * 2006-08-03 2013-12-11 アストラゼネカ・アクチエボラーグ αＶβ６に対する抗体およびその使用
US9512236B2 (en) * 2006-12-19 2016-12-06 Ablynx N.V. Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
AU2008233051B2 (en) 2007-03-30 2014-04-10 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
EP2192922A4 (en) * 2007-09-17 2010-09-29 Univ California INTERNALIZING HUMAN MONOCLONAL ANTIBODIES TARGING PROSTATE <I> IN SITU CANCER CELLS </ I>
US7947807B2 (en) * 2007-10-15 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)
EP2214711B1 (en) 2007-10-25 2018-08-15 Trellis RSV Holdings, Inc. Anti-rsv g protein antibodies
RU2531758C2 (ru) * 2008-02-11 2014-10-27 Куретек Лтд. Моноклональные антитела для лечения опухолей
US9217032B2 (en) * 2010-01-08 2015-12-22 Les Laboratoires Servier Methods for treating colorectal cancer
CA2806250C (en) * 2010-07-22 2020-09-22 John W. Schrader Cross-protective pathogen protection, methods and compositions thereof
SG10201510092QA (en) 2010-12-09 2016-01-28 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
CN103483452B (zh) 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
JO3519B1 (ar) * 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
CN105142677B (zh) 2013-02-15 2019-08-30 加利福尼亚大学董事会 嵌合抗原受体及其使用方法
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
WO2014191128A1 (en) 2013-05-29 2014-12-04 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
EP3119423B1 (en) 2014-03-15 2022-12-14 Novartis AG Treatment of cancer using chimeric antigen receptor
US9884921B2 (en) * 2014-07-01 2018-02-06 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
IL310130A (en) * 2014-12-05 2024-03-01 Memorial Sloan Kettering Cancer Center G-protein receptor-directed chimeric antigen receptors and their use
CN115925973A (zh) * 2015-10-23 2023-04-07 优瑞科生物技术公司 抗体/t细胞受体嵌合构建体及其用途
KR20230148844A (ko) 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
AU2017240233B2 (en) * 2016-03-31 2022-07-14 University Of Southern California A highly sensitive and specific luciferase based reporter assay for antigen detection
WO2020092854A2 (en) * 2018-11-01 2020-05-07 Juno Therapeutics, Inc. Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d)

Also Published As

Publication number Publication date
PH12017501039A1 (en) 2018-03-05
JP2022103382A (ja) 2022-07-07
JP2020191900A (ja) 2020-12-03
MX2022001878A (es) 2022-03-11
IL252646A0 (en) 2017-07-31
MX2022009463A (es) 2022-09-05
NZ732567A (en) 2023-10-27
JP2018504890A (ja) 2018-02-22
BR112017011932A2 (pt) 2018-01-16
AU2015357535A1 (en) 2017-06-29
JP2022044638A (ja) 2022-03-17
RU2017123545A (ru) 2019-01-14
IL285101B1 (en) 2023-11-01
CA2969886A1 (en) 2016-06-09
KR20170108945A (ko) 2017-09-27
CN113429482A (zh) 2021-09-24
MX2017007247A (es) 2018-01-25
CN113429484A (zh) 2021-09-24
HK1243955A1 (zh) 2018-07-27
SA517381664B1 (ar) 2021-12-27
SG11201704552TA (en) 2017-07-28
JP6753851B2 (ja) 2020-09-09
CN107206077B (zh) 2021-06-08
AU2023270242A1 (en) 2023-12-14
WO2016090329A2 (en) 2016-06-09
KR102602417B1 (ko) 2023-11-16
AU2020217320A1 (en) 2020-08-27
MY195115A (en) 2023-01-10
JP7027482B2 (ja) 2022-03-01
JP2020120684A (ja) 2020-08-13
KR20230159637A (ko) 2023-11-21
EP3227324A4 (en) 2018-08-29
IL285101B2 (en) 2024-03-01
US20200123249A1 (en) 2020-04-23
RU2725819C2 (ru) 2020-07-06
IL307767A (en) 2023-12-01
IL285101A (en) 2021-08-31
EP3227324A2 (en) 2017-10-11
US20180118822A1 (en) 2018-05-03
IL252646B (en) 2021-08-31
RU2020120613A (ru) 2021-12-06
CN107206077A (zh) 2017-09-26
US11566071B2 (en) 2023-01-31
SG10201913937QA (en) 2020-03-30
RU2017123545A3 (pt) 2019-12-11
US10590196B2 (en) 2020-03-17
WO2016090329A3 (en) 2016-07-28
US20200123250A1 (en) 2020-04-23
AU2015357535B2 (en) 2020-05-14
US20240076370A1 (en) 2024-03-07

Similar Documents

Publication Publication Date Title
BR112017011932A8 (pt) Anticorpos direcionados a receptor acoplado a proteína g e métodos de uso
CR20150618A (es) Anticuerpos receptores de antitransferina y métodos de uso
BR112016022658A2 (pt) anticorpos anti-ox40 e métodos de uso
CL2018000920A1 (es) Conjugados de anticuerpos que comprenden agonistas de receptor similares
BR112015032224A2 (pt) anticorpos anti-fcrh5
CL2017001408A1 (es) Anticuerpos anti-cd79b y métodos de uso
CL2017000590A1 (es) Anticuerpos anti-cll-1 e inmunoconjugados
BR112017017927A2 (pt) receptores quiméricos de antígenos anti-dll3 e métodos de uso
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
CL2017000545A1 (es) Anticuerpos anti-her2 e inmunoconjugados
BR112017011234A2 (pt) anticorpos contra receptor da barreira hematoencefálica e métodos de uso
CL2016001102A1 (es) Anticuerpos anti-claudina novedosos y métodos de uso.
BR112016025291A2 (pt) conjugados de anticorpo anti-ptk7-fármaco
DK3221346T3 (da) Antistoffer omfattende modificerede konstante områder af tungkæden
CL2015002562A1 (es) Anticuerpos e inmunoconjugados anti-b7-h4
BR112016018891A2 (pt) anticorpos anti-dll3 e conjugados de fármacos para uso em melanoma
EA201691610A1 (ru) Анти-jagged1 антитела и способы применения
BR112017009297A2 (pt) anticorpos antifator de complemento c1q humanizados e usos dos mesmos
CL2016001432A1 (es) Nuevos anticuerpos anti-dpep3 y métodos de uso
BR112016004245A2 (pt) moduladores de sez6 e métodos de uso
BR112016022113A2 (pt) anticorpos anti-hemaglutinina do vírus influenza b e métodos de uso
ECSP17031725A (es) Receptores quiméricos de anitígeno anti-clon y métodos de uso
CR20140382A (es) Anticuerpos anti-lrp5 y metodos de uso
BR112016014731A2 (pt) Anticorpos anti-baff
CL2018001139A1 (es) Anticuerpos anti-htra1 y métodos de uso de los mismos.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: MEMORIAL SLOAN-KETTERING CANCER CENTER (US) ; EUREKA THERAPEUTICS, INC. (US)

B25G Requested change of headquarter approved

Owner name: MEMORIAL SLOAN-KETTERING CANCER CENTER (US) ; EUREKA THERAPEUTICS, INC. (US)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]