MX2020001491A - Metodos y composiciones para preparar celulas geneticamente modificadas. - Google Patents
Metodos y composiciones para preparar celulas geneticamente modificadas.Info
- Publication number
- MX2020001491A MX2020001491A MX2020001491A MX2020001491A MX2020001491A MX 2020001491 A MX2020001491 A MX 2020001491A MX 2020001491 A MX2020001491 A MX 2020001491A MX 2020001491 A MX2020001491 A MX 2020001491A MX 2020001491 A MX2020001491 A MX 2020001491A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- cells
- genetically engineered
- naive
- receptors
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 9
- 239000000203 mixture Substances 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 108010083359 Antigen Receptors Proteins 0.000 abstract 1
- 102000006306 Antigen Receptors Human genes 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 108700010039 chimeric receptor Proteins 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000009258 tissue cross reactivity Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/4611—
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- A61K39/4631—
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- A61K39/464412—
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- A61K39/464417—
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se proporcionan métodos para preparar células T para la terapia celular, composiciones producidas por los métodos, y métodos para administrar las células a sujetos. En particular, la descripción se refiere a la preparación de células T modificadas, tal como aquellas que expresan receptores modificados genéticamente, tal como receptores de antígenos modificados genéticamente tal como los TCR modificados y receptores de antígenos quiméricos (CAR), u otros receptores quiméricos recombinantes. Las características de los métodos incluyen la producción de un producto de células T más consistente y/o predecible y/o menor toxicidad en comparación a otros métodos. Los métodos proporcionados incluyen incubar células bajo condiciones de estimulación para inducir la expansión o proliferación de células T tipo sin tratamiento previo en comparación a células T no de tipo sin tratamiento previo en la composición estimulada, que a su vez puede dar por resultado la transducción preferencial de células derivadas de las células T tipo sin tratamiento previo. Las características de los métodos también pueden incluir la reducción en costos, números de pasos, y gasto de recursos en comparación a otros métodos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762543359P | 2017-08-09 | 2017-08-09 | |
| PCT/US2018/046151 WO2019032929A1 (en) | 2017-08-09 | 2018-08-09 | METHODS AND COMPOSITIONS FOR PREPARING GENETICALLY MODIFIED CELLS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020001491A true MX2020001491A (es) | 2020-08-06 |
Family
ID=63405422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020001491A MX2020001491A (es) | 2017-08-09 | 2018-08-09 | Metodos y composiciones para preparar celulas geneticamente modificadas. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20200239910A1 (es) |
| EP (1) | EP3664835B1 (es) |
| JP (2) | JP2020530294A (es) |
| KR (1) | KR20200046045A (es) |
| CN (1) | CN111263641A (es) |
| AU (1) | AU2018313952A1 (es) |
| BR (1) | BR112020001601A2 (es) |
| CA (1) | CA3070575A1 (es) |
| MA (1) | MA49981A (es) |
| MX (1) | MX2020001491A (es) |
| NZ (1) | NZ761124A (es) |
| WO (1) | WO2019032929A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12049667B2 (en) | 2017-05-26 | 2024-07-30 | Abvitro Llc | High-throughput polynucleotide library sequencing and transcriptome analysis |
| AU2018275894A1 (en) | 2017-06-02 | 2019-12-12 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| KR20200054178A (ko) | 2017-08-09 | 2020-05-19 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포 조성물 및 관련 조성물의 제조 방법 |
| CA3108657A1 (en) * | 2018-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| KR20220015452A (ko) | 2019-05-28 | 2022-02-08 | 밀테니 비오텍 비.브이. & 씨오. 케이지 | 유전자 변형된 t 세포의 생성 방법 |
| KR20220131892A (ko) | 2019-11-05 | 2022-09-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료용 ｔ 세포 조성물의 속성 결정 방법 |
| KR20230024283A (ko) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도 |
| CN116249716A (zh) | 2020-07-07 | 2023-06-09 | 康愈有限责任公司 | Mic抗体和结合剂及其使用方法 |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
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2018
- 2018-08-09 KR KR1020207006719A patent/KR20200046045A/ko not_active Application Discontinuation
- 2018-08-09 JP JP2020506981A patent/JP2020530294A/ja active Pending
- 2018-08-09 CA CA3070575A patent/CA3070575A1/en active Pending
- 2018-08-09 MX MX2020001491A patent/MX2020001491A/es unknown
- 2018-08-09 WO PCT/US2018/046151 patent/WO2019032929A1/en unknown
- 2018-08-09 NZ NZ761124A patent/NZ761124A/en unknown
- 2018-08-09 AU AU2018313952A patent/AU2018313952A1/en active Pending
- 2018-08-09 EP EP18760160.4A patent/EP3664835B1/en active Active
- 2018-08-09 MA MA049981A patent/MA49981A/fr unknown
- 2018-08-09 US US16/637,447 patent/US20200239910A1/en not_active Abandoned
- 2018-08-09 BR BR112020001601-2A patent/BR112020001601A2/pt unknown
- 2018-08-09 CN CN201880065088.1A patent/CN111263641A/zh active Pending
-
2023
- 2023-02-03 JP JP2023015156A patent/JP2023055888A/ja active Pending
-
2024
- 2024-03-26 US US18/617,271 patent/US20240368625A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020530294A (ja) | 2020-10-22 |
| RU2020109867A3 (es) | 2022-01-10 |
| RU2020109867A (ru) | 2021-09-14 |
| US20200239910A1 (en) | 2020-07-30 |
| JP2023055888A (ja) | 2023-04-18 |
| NZ761124A (en) | 2024-07-05 |
| KR20200046045A (ko) | 2020-05-06 |
| WO2019032929A1 (en) | 2019-02-14 |
| MA49981A (fr) | 2020-06-17 |
| AU2018313952A1 (en) | 2020-02-13 |
| CN111263641A (zh) | 2020-06-09 |
| US20240368625A1 (en) | 2024-11-07 |
| EP3664835A1 (en) | 2020-06-17 |
| BR112020001601A2 (pt) | 2020-08-11 |
| EP3664835B1 (en) | 2024-10-23 |
| CA3070575A1 (en) | 2019-02-14 |
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