MX2020005908A - Proceso para producir una composicion de celulas t modificadas. - Google Patents
Proceso para producir una composicion de celulas t modificadas.Info
- Publication number
- MX2020005908A MX2020005908A MX2020005908A MX2020005908A MX2020005908A MX 2020005908 A MX2020005908 A MX 2020005908A MX 2020005908 A MX2020005908 A MX 2020005908A MX 2020005908 A MX2020005908 A MX 2020005908A MX 2020005908 A MX2020005908 A MX 2020005908A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- aspects
- engineered
- producing
- composition
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 abstract 2
- 238000002659 cell therapy Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000011176 pooling Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
La presente descripción proporciona métodos para modificar genéticamente células T, tal como células T CD4+ y/o células T CD8+, para uso en terapia celular. En algunos aspectos, los métodos proporcionados incluyen uno o más pasos para agrupar células CD4+ y CD8+ enriquecidas, tal como a una relación 1:1, y luego incubar las células bajo condiciones de estimulación, introducir un polipéptido recombinante a las células a través de transducción o transfección y/o cultivar las células bajo condiciones que promuevan la proliferación y/o expansión. En algunos aspectos, los métodos proporcionados son un medio eficiente y confiable para producir células T genéticamente modificadas con un alto grado de éxito.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762596774P | 2017-12-08 | 2017-12-08 | |
US201862614965P | 2018-01-08 | 2018-01-08 | |
US201862716971P | 2018-08-09 | 2018-08-09 | |
US201862721604P | 2018-08-22 | 2018-08-22 | |
US201862740903P | 2018-10-03 | 2018-10-03 | |
US201862754564P | 2018-11-01 | 2018-11-01 | |
US201862774165P | 2018-11-30 | 2018-11-30 | |
US201862774855P | 2018-12-03 | 2018-12-03 | |
PCT/US2018/064628 WO2019113557A1 (en) | 2017-12-08 | 2018-12-07 | Process for producing a composition of engineered t cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020005908A true MX2020005908A (es) | 2020-10-07 |
Family
ID=64949447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005908A MX2020005908A (es) | 2017-12-08 | 2018-12-07 | Proceso para producir una composicion de celulas t modificadas. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20200384025A1 (es) |
EP (1) | EP3720874A1 (es) |
JP (2) | JP2021505168A (es) |
KR (1) | KR20200108278A (es) |
CN (1) | CN112004824A (es) |
AU (1) | AU2018379092A1 (es) |
BR (1) | BR112020011215A2 (es) |
CA (1) | CA3084445A1 (es) |
IL (1) | IL275111A (es) |
MA (1) | MA51114A (es) |
MX (1) | MX2020005908A (es) |
SG (1) | SG11202005272SA (es) |
WO (1) | WO2019113557A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
CN108474002B (zh) | 2015-10-22 | 2023-05-23 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
JP6609724B1 (ja) | 2017-01-06 | 2019-11-20 | ユーティレックス カンパニー リミテッド | 抗ヒト4−1bb抗体およびその使用 |
ES2959953T3 (es) | 2017-08-09 | 2024-02-29 | Juno Therapeutics Inc | Métodos para producir composiciones celulares genéticamente modificadas y composiciones relacionadas |
AU2018360599A1 (en) * | 2017-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
US20220412954A1 (en) | 2019-11-05 | 2022-12-29 | Juno Therapeutics, Inc. | Methods of determining attributes of therapeutic t cell compositions |
JP2023519099A (ja) * | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Bcma指向性キメラ抗原受容体t細胞組成物ならびにその方法および使用 |
WO2022005462A1 (en) * | 2020-06-30 | 2022-01-06 | Tr1X, Inc. | Poly-donor cd4+ t cells expressing il-10 and uses thereof |
CN113207871A (zh) * | 2021-05-20 | 2021-08-06 | 新乡医学院 | 一种用于体外保存t记忆性干细胞的储存液及其应用 |
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-
2018
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- 2018-12-07 SG SG11202005272SA patent/SG11202005272SA/en unknown
- 2018-12-07 KR KR1020207019671A patent/KR20200108278A/ko active Search and Examination
- 2018-12-07 CA CA3084445A patent/CA3084445A1/en active Pending
- 2018-12-07 EP EP18830101.4A patent/EP3720874A1/en active Pending
- 2018-12-07 BR BR112020011215-1A patent/BR112020011215A2/pt unknown
- 2018-12-07 AU AU2018379092A patent/AU2018379092A1/en active Pending
- 2018-12-07 CN CN201880088430.XA patent/CN112004824A/zh active Pending
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- 2018-12-07 WO PCT/US2018/064628 patent/WO2019113557A1/en unknown
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EP3720874A1 (en) | 2020-10-14 |
JP2021505168A (ja) | 2021-02-18 |
CN112004824A (zh) | 2020-11-27 |
BR112020011215A2 (pt) | 2020-11-17 |
US20200384025A1 (en) | 2020-12-10 |
IL275111A (en) | 2020-07-30 |
JP2024026186A (ja) | 2024-02-28 |
MA51114A (fr) | 2020-10-14 |
SG11202005272SA (en) | 2020-07-29 |
CA3084445A1 (en) | 2019-06-13 |
AU2018379092A1 (en) | 2020-06-25 |
KR20200108278A (ko) | 2020-09-17 |
WO2019113557A1 (en) | 2019-06-13 |
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