AR108427A1 - Antígeno quimérico y receptores de células t y métodos de uso - Google Patents

Antígeno quimérico y receptores de células t y métodos de uso

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Publication number
AR108427A1
AR108427A1 ARP170100823A ARP170100823A AR108427A1 AR 108427 A1 AR108427 A1 AR 108427A1 AR P170100823 A ARP170100823 A AR P170100823A AR P170100823 A ARP170100823 A AR P170100823A AR 108427 A1 AR108427 A1 AR 108427A1
Authority
AR
Argentina
Prior art keywords
cell
domain
polypeptide
polynucleotide
vector
Prior art date
Application number
ARP170100823A
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English (en)
Original Assignee
Kite Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of AR108427A1 publication Critical patent/AR108427A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/17—Hinge-spacer domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70589—CD45
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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Abstract

Reivindicación 1: Un polinucleótido aislado que codifica un receptor de antígeno quimérico (CAR) o un receptor de células T (TCR), que comprende (i) una molécula de unión a antígeno, (ii) un dominio coestimulatorio, y (iii) un dominio activante, en donde el dominio coestimulatorio comprende un dominio extracelular, un dominio transmembrana y un dominio intracelular, en donde el dominio extracelular comprende un dominio de bisagra truncado que consiste esencialmente en o consiste en (i) una secuencia de aminoácidos al menos aproximadamente 80%, al menos aproximadamente 85%, al menos aproximadamente 90%, al menos aproximadamente 95%, al menos aproximadamente 96%, al menos aproximadamente 97%, al menos aproximadamente 98%, al menos aproximadamente 99% o aproximadamente 100% idéntica a los aminoácidos 123 a 152 de SEQ ID Nº 1 y, opcionalmente, (ii) uno a seis aminoácidos. Reivindicación 25: La célula de la reivindicación 24, en donde la célula T es un célula T alogénica, una célula T autóloga, una célula T autóloga modificada genéticamente (eACT), o u linfocito infiltrante del tumor (TIL). Reivindicación 30: Una composición que comprende el polinucleótido de cualquiera de las reivindicaciones 1 a 19, el vector de la reivindicación 20 ó 21, el polipéptido de la reivindicación 22, o la célula de cualquiera de las reivindicaciones 23 a 29. Reivindicación 35: Un método para tratar un cáncer en un sujeto que lo necesita, que comprende administrar al sujeto el polinucleótido de cualquiera de las reivindicaciones 1 a 19, el vector de la reivindicación 20 ó 21, el polipéptido de la reivindicación 22, la célula de cualquiera de las reivindicaciones 23 a 29, o la composición de la reivindicación 30 ó 31.
ARP170100823A 2016-04-01 2017-03-31 Antígeno quimérico y receptores de células t y métodos de uso AR108427A1 (es)

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JP (2) JP7034934B2 (es)
KR (2) KR102427334B1 (es)
CN (1) CN109328074A (es)
AR (2) AR108427A1 (es)
AU (2) AU2017240667C1 (es)
BR (1) BR112018070073A2 (es)
CA (1) CA3019149A1 (es)
CL (2) CL2018002762A1 (es)
CO (1) CO2018010453A2 (es)
CR (1) CR20180461A (es)
CU (1) CU20180121A7 (es)
DO (1) DOP2018000213A (es)
EA (1) EA201891965A1 (es)
EC (1) ECSP18073833A (es)
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GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
NZ727167A (en) * 2014-06-02 2024-07-05 The Us Secretary Department Of Health And Human Services Chimeric antigen receptors targeting cd-19
WO2022081604A1 (en) * 2020-10-12 2022-04-21 Hpvvax, Llc Composition and method for treating cancer using a vaccine as a first therapueutic active ingredient in combination with a second active ingredient
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