JO3633B1 - مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك - Google Patents
مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنكInfo
- Publication number
- JO3633B1 JO3633B1 JOP/2016/0197A JOP20160197A JO3633B1 JO 3633 B1 JO3633 B1 JO 3633B1 JO P20160197 A JOP20160197 A JO P20160197A JO 3633 B1 JO3633 B1 JO 3633B1
- Authority
- JO
- Jordan
- Prior art keywords
- fennel
- fever
- compounds
- inhibitors
- substituted indole
- Prior art date
Links
- 235000004204 Foeniculum vulgare Nutrition 0.000 title abstract 3
- 206010037660 Pyrexia Diseases 0.000 title abstract 3
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 240000006927 Foeniculum vulgare Species 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 241000212314 Foeniculum Species 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات اندول مستبدلة احاديا أو ثنائيا وبطرق لمنع او معالجة الاصابات الفيروسية باستخدام المركبات المذكورة. وكما يتعلق بالمركبات المذكورة بخصوص استخدامها كدواء والافضل لاستخدامها كعلاج لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاختراع الحالي بتركيبات صيدلانية أو مستحضرات متحدة من المركبات، وبالتركيبات أو المستحضرات لاستخدامها كدواء، والافضل لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاخراع بعمليات و طرق لتحضير هذه المركبات.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185522 | 2015-09-16 | ||
| EP16163465 | 2016-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3633B1 true JO3633B1 (ar) | 2020-08-27 |
Family
ID=56958913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2016/0197A JO3633B1 (ar) | 2015-09-16 | 2016-09-06 | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US10786484B2 (ar) |
| EP (1) | EP3350163B1 (ar) |
| JP (2) | JP7045984B2 (ar) |
| KR (1) | KR102676442B1 (ar) |
| CN (1) | CN108368044B (ar) |
| AU (1) | AU2016323535B2 (ar) |
| CA (1) | CA2996856C (ar) |
| CL (1) | CL2018000697A1 (ar) |
| CO (1) | CO2018003369A2 (ar) |
| CR (1) | CR20180214A (ar) |
| CY (1) | CY1122792T1 (ar) |
| DK (1) | DK3350163T3 (ar) |
| EA (1) | EA035679B1 (ar) |
| EC (1) | ECSP18020039A (ar) |
| ES (1) | ES2778431T3 (ar) |
| HR (1) | HRP20200408T1 (ar) |
| IL (1) | IL258031B (ar) |
| JO (1) | JO3633B1 (ar) |
| LT (1) | LT3350163T (ar) |
| MA (1) | MA42811B1 (ar) |
| MD (1) | MD3350163T2 (ar) |
| ME (1) | ME03674B (ar) |
| MX (1) | MX381632B (ar) |
| MY (1) | MY188347A (ar) |
| NI (1) | NI201800040A (ar) |
| PE (1) | PE20181007A1 (ar) |
| PH (1) | PH12018500569B1 (ar) |
| PL (1) | PL3350163T3 (ar) |
| PT (1) | PT3350163T (ar) |
| RS (1) | RS60039B1 (ar) |
| SI (1) | SI3350163T1 (ar) |
| SM (1) | SMT202000140T1 (ar) |
| TW (1) | TWI758256B (ar) |
| UA (1) | UA123672C2 (ar) |
| UY (1) | UY36904A (ar) |
| WO (1) | WO2017046258A1 (ar) |
| ZA (1) | ZA201801764B (ar) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR101818521B1 (ko) * | 2011-11-16 | 2018-01-16 | 대우조선해양 주식회사 | 마이크로채널 열교환기용 2상 유체 공급장치 및 그 방법 |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN114591242B (zh) | 2015-12-16 | 2025-01-07 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| EA201892216A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| US10730884B2 (en) | 2016-04-01 | 2020-08-04 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| UA125970C2 (uk) | 2017-05-22 | 2022-07-20 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| WO2024178504A1 (en) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using |
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| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| AU2002364566B2 (en) | 2001-12-12 | 2009-03-26 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating HSP90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| MX2007008587A (es) | 2005-01-14 | 2007-09-07 | Genelabs Tech Inc | Derivados de indol para tratamiento de infecciones virales. |
| EA200701669A1 (ru) | 2005-02-09 | 2008-02-28 | Мидженикс Инк. | Композиции и способы лечения или предотвращения инфекций, вызванных вирусами семейства flaviviridae |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| MX338530B (es) | 2008-06-03 | 2016-04-21 | Siga Technologies Inc | Inhibidores de molecula pequeña para el tratamiento o prevencion de infeccion de virus del dengue. |
| EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | MIF MODULATORS |
| ES2612731T3 (es) | 2008-08-19 | 2017-05-18 | Janssen Pharmaceutica Nv | Antagonistas de receptores al frío de mentol |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| NZ600816A (en) | 2010-01-15 | 2014-08-29 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JP6030035B2 (ja) | 2013-09-27 | 2016-11-24 | 富士フイルム株式会社 | 蛍光観察装置、内視鏡システム及びプロセッサ装置並びに作動方法 |
| SG11201602748XA (en) * | 2013-10-23 | 2016-05-30 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| ES2687498T3 (es) | 2014-01-31 | 2018-10-25 | Bristol-Myers Squibb Company | Macrociclos con grupos P2¿ heterocíclicos como inhibidores del factor XIa |
| HRP20190199T1 (hr) | 2014-10-01 | 2019-04-05 | Janssen Pharmaceuticals, Inc. | Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa |
| NO2721243T3 (ar) | 2014-10-01 | 2018-10-20 | ||
| BR112017006708A2 (pt) | 2014-10-01 | 2017-12-26 | Janssen Pharmaceuticals Inc | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue |
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3002214C (en) | 2015-11-03 | 2022-01-04 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| EA201892216A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индолина в качестве ингибиторов репликации вирусов денге |
| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SG10202009589UA (en) | 2016-04-01 | 2020-10-29 | Signal Pharm Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| PL3436079T3 (pl) | 2016-04-01 | 2021-12-20 | Kite Pharma, Inc. | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania |
| SG11201808622SA (en) | 2016-04-01 | 2018-10-30 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
| US10730884B2 (en) | 2016-04-01 | 2020-08-04 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| PT3436030T (pt) | 2016-04-01 | 2022-11-18 | Amgen Inc | Recetores quiméricos e métodos para a sua utilização |
| US11570992B2 (en) | 2016-04-01 | 2023-02-07 | Basf Se | Bicyclic compounds |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| US11407715B2 (en) | 2017-05-22 | 2022-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| UA125970C2 (uk) | 2017-05-22 | 2022-07-20 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
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2016
- 2016-09-06 JO JOP/2016/0197A patent/JO3633B1/ar active
- 2016-09-13 TW TW105129691A patent/TWI758256B/zh not_active IP Right Cessation
- 2016-09-15 MA MA42811A patent/MA42811B1/fr unknown
- 2016-09-15 EA EA201890723A patent/EA035679B1/ru not_active IP Right Cessation
- 2016-09-15 AU AU2016323535A patent/AU2016323535B2/en active Active
- 2016-09-15 ES ES16767235T patent/ES2778431T3/es active Active
- 2016-09-15 EP EP16767235.1A patent/EP3350163B1/en active Active
- 2016-09-15 LT LTEP16767235.1T patent/LT3350163T/lt unknown
- 2016-09-15 SI SI201630686T patent/SI3350163T1/sl unknown
- 2016-09-15 RS RS20200272A patent/RS60039B1/sr unknown
- 2016-09-15 ME MEP-2020-53A patent/ME03674B/me unknown
- 2016-09-15 CR CR20180214A patent/CR20180214A/es unknown
- 2016-09-15 PE PE2018000391A patent/PE20181007A1/es unknown
- 2016-09-15 WO PCT/EP2016/071852 patent/WO2017046258A1/en not_active Ceased
- 2016-09-15 CA CA2996856A patent/CA2996856C/en active Active
- 2016-09-15 US US15/759,844 patent/US10786484B2/en active Active
- 2016-09-15 KR KR1020187009485A patent/KR102676442B1/ko active Active
- 2016-09-15 SM SM20200140T patent/SMT202000140T1/it unknown
- 2016-09-15 UA UAA201804016A patent/UA123672C2/uk unknown
- 2016-09-15 PL PL16767235T patent/PL3350163T3/pl unknown
- 2016-09-15 MX MX2018003256A patent/MX381632B/es unknown
- 2016-09-15 PH PH1/2018/500569A patent/PH12018500569B1/en unknown
- 2016-09-15 PT PT167672351T patent/PT3350163T/pt unknown
- 2016-09-15 MD MDE20180704T patent/MD3350163T2/ro unknown
- 2016-09-15 JP JP2018513845A patent/JP7045984B2/ja active Active
- 2016-09-15 MY MYPI2018000378A patent/MY188347A/en unknown
- 2016-09-15 CN CN201680053589.9A patent/CN108368044B/zh active Active
- 2016-09-15 DK DK16767235.1T patent/DK3350163T3/da active
- 2016-09-15 HR HRP20200408TT patent/HRP20200408T1/hr unknown
- 2016-09-16 UY UY0001036904A patent/UY36904A/es not_active Application Discontinuation
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2018
- 2018-03-12 IL IL258031A patent/IL258031B/en active IP Right Grant
- 2018-03-14 EC ECIEPI201820039A patent/ECSP18020039A/es unknown
- 2018-03-15 CL CL2018000697A patent/CL2018000697A1/es unknown
- 2018-03-15 NI NI201800040A patent/NI201800040A/es unknown
- 2018-03-15 ZA ZA2018/01764A patent/ZA201801764B/en unknown
- 2018-03-26 CO CONC2018/0003369A patent/CO2018003369A2/es unknown
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2020
- 2020-03-12 CY CY20201100216T patent/CY1122792T1/el unknown
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2021
- 2021-08-20 JP JP2021135171A patent/JP2021193092A/ja active Pending
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