JO3633B1 - مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك - Google Patents

مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Info

Publication number
JO3633B1
JO3633B1 JOP/2016/0197A JOP20160197A JO3633B1 JO 3633 B1 JO3633 B1 JO 3633B1 JO P20160197 A JOP20160197 A JO P20160197A JO 3633 B1 JO3633 B1 JO 3633B1
Authority
JO
Jordan
Prior art keywords
dengue viral
mono
compounds
substituted indole
viral replication
Prior art date
Application number
JOP/2016/0197A
Other languages
English (en)
Inventor
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Dorothée Alice Marie-Eve Bardiot
Bart Rudolf Romanie Kesteleyn
Original Assignee
Katholieke Univ Leuven Ku Leuven Research & Development
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Univ Leuven Ku Leuven Research & Development, Janssen Pharmaceuticals Inc filed Critical Katholieke Univ Leuven Ku Leuven Research & Development
Application granted granted Critical
Publication of JO3633B1 publication Critical patent/JO3633B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

يتعلق الاختراع الحالي بمركبات اندول مستبدلة احاديا أو ثنائيا وبطرق لمنع او معالجة الاصابات الفيروسية باستخدام المركبات المذكورة. وكما يتعلق بالمركبات المذكورة بخصوص استخدامها كدواء والافضل لاستخدامها كعلاج لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاختراع الحالي بتركيبات صيدلانية أو مستحضرات متحدة من المركبات، وبالتركيبات أو المستحضرات لاستخدامها كدواء، والافضل لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاخراع بعمليات و طرق لتحضير هذه المركبات.
JOP/2016/0197A 2015-09-16 2016-09-06 مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك JO3633B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15185522 2015-09-16
EP16163465 2016-04-01

Publications (1)

Publication Number Publication Date
JO3633B1 true JO3633B1 (ar) 2020-08-27

Family

ID=56958913

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0197A JO3633B1 (ar) 2015-09-16 2016-09-06 مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Country Status (37)

Country Link
US (1) US10786484B2 (ar)
EP (1) EP3350163B1 (ar)
JP (2) JP7045984B2 (ar)
KR (1) KR20180051563A (ar)
CN (1) CN108368044B (ar)
AU (1) AU2016323535B2 (ar)
CA (1) CA2996856C (ar)
CL (1) CL2018000697A1 (ar)
CO (1) CO2018003369A2 (ar)
CR (1) CR20180214A (ar)
CY (1) CY1122792T1 (ar)
DK (1) DK3350163T3 (ar)
EA (1) EA035679B1 (ar)
EC (1) ECSP18020039A (ar)
ES (1) ES2778431T3 (ar)
HK (1) HK1258320A1 (ar)
HR (1) HRP20200408T1 (ar)
IL (1) IL258031B (ar)
JO (1) JO3633B1 (ar)
LT (1) LT3350163T (ar)
MA (1) MA42811B1 (ar)
MD (1) MD3350163T2 (ar)
ME (1) ME03674B (ar)
MX (1) MX2018003256A (ar)
MY (1) MY188347A (ar)
NI (1) NI201800040A (ar)
PE (1) PE20181007A1 (ar)
PH (1) PH12018500569A1 (ar)
PL (1) PL3350163T3 (ar)
PT (1) PT3350163T (ar)
RS (1) RS60039B1 (ar)
SI (1) SI3350163T1 (ar)
TW (1) TWI758256B (ar)
UA (1) UA123672C2 (ar)
UY (1) UY36904A (ar)
WO (1) WO2017046258A1 (ar)
ZA (1) ZA201801764B (ar)

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Also Published As

Publication number Publication date
CN108368044A (zh) 2018-08-03
UA123672C2 (uk) 2021-05-12
JP2018528222A (ja) 2018-09-27
PE20181007A1 (es) 2018-06-26
ZA201801764B (en) 2021-04-28
PT3350163T (pt) 2020-03-23
MY188347A (en) 2021-12-02
DK3350163T3 (da) 2020-03-16
CN108368044B (zh) 2021-06-15
MX2018003256A (es) 2018-11-09
RS60039B1 (sr) 2020-04-30
EA201890723A1 (ru) 2018-08-31
CA2996856A1 (en) 2017-03-23
CL2018000697A1 (es) 2018-07-06
CA2996856C (en) 2023-08-01
US20180256544A1 (en) 2018-09-13
HK1258320A1 (zh) 2019-11-08
IL258031A (en) 2018-05-31
PL3350163T3 (pl) 2020-08-24
ME03674B (me) 2020-10-20
EP3350163B1 (en) 2019-12-25
CR20180214A (es) 2018-05-14
MA42811B1 (fr) 2020-03-31
KR20180051563A (ko) 2018-05-16
EP3350163A1 (en) 2018-07-25
TWI758256B (zh) 2022-03-21
US10786484B2 (en) 2020-09-29
AU2016323535A1 (en) 2018-03-08
CY1122792T1 (el) 2021-05-05
IL258031B (en) 2021-03-25
WO2017046258A1 (en) 2017-03-23
UY36904A (es) 2017-03-31
ES2778431T3 (es) 2020-08-10
EA035679B1 (ru) 2020-07-24
PH12018500569A1 (en) 2018-09-17
AU2016323535B2 (en) 2021-02-18
TW201722912A (zh) 2017-07-01
ECSP18020039A (es) 2018-04-30
SI3350163T1 (sl) 2020-07-31
JP2021193092A (ja) 2021-12-23
MD3350163T2 (ro) 2020-06-30
MA42811A (fr) 2018-07-25
HRP20200408T1 (hr) 2020-06-12
NI201800040A (es) 2018-07-24
LT3350163T (lt) 2020-04-10
CO2018003369A2 (es) 2018-07-10
JP7045984B2 (ja) 2022-04-01

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