MA42811B1 - Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents

Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Info

Publication number
MA42811B1
MA42811B1 MA42811A MA42811A MA42811B1 MA 42811 B1 MA42811 B1 MA 42811B1 MA 42811 A MA42811 A MA 42811A MA 42811 A MA42811 A MA 42811A MA 42811 B1 MA42811 B1 MA 42811B1
Authority
MA
Morocco
Prior art keywords
monosubstituted
inhibitors
compounds
dengue virus
virus replication
Prior art date
Application number
MA42811A
Other languages
English (en)
Other versions
MA42811A (fr
Inventor
Jean-François Bonfanti
Bart Rudolf Romanie Kesteleyn
Pierre Jean-Marie Bernard Raboisson
Tim Hugo Maria Jonckers
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA42811A publication Critical patent/MA42811A/fr
Publication of MA42811B1 publication Critical patent/MA42811B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des composés indoles mono- ou di-substitués, des procédés pour prévenir ou traiter les infections virales de la dengue en utilisant lesdits composés et concerne également lesdits composés à utiliser comme médicament, plus préférablement à utiliser comme médicament pour traiter ou prévenir la dengue virale infections. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations destinées à être utilisées comme médicament, plus préférablement pour la prévention ou le traitement des infections virales de la dengue. L'invention concerne également des procédés de préparation des composés.
MA42811A 2015-09-16 2016-09-15 Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue MA42811B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15185522 2015-09-16
EP16163465 2016-04-01
PCT/EP2016/071852 WO2017046258A1 (fr) 2015-09-16 2016-09-15 Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Publications (2)

Publication Number Publication Date
MA42811A MA42811A (fr) 2018-07-25
MA42811B1 true MA42811B1 (fr) 2020-03-31

Family

ID=56958913

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42811A MA42811B1 (fr) 2015-09-16 2016-09-15 Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Country Status (37)

Country Link
US (1) US10786484B2 (fr)
EP (1) EP3350163B1 (fr)
JP (2) JP7045984B2 (fr)
KR (1) KR102676442B1 (fr)
CN (1) CN108368044B (fr)
AU (1) AU2016323535B2 (fr)
CA (1) CA2996856C (fr)
CL (1) CL2018000697A1 (fr)
CO (1) CO2018003369A2 (fr)
CR (1) CR20180214A (fr)
CY (1) CY1122792T1 (fr)
DK (1) DK3350163T3 (fr)
EA (1) EA035679B1 (fr)
EC (1) ECSP18020039A (fr)
ES (1) ES2778431T3 (fr)
HK (1) HK1258320A1 (fr)
HR (1) HRP20200408T1 (fr)
IL (1) IL258031B (fr)
JO (1) JO3633B1 (fr)
LT (1) LT3350163T (fr)
MA (1) MA42811B1 (fr)
MD (1) MD3350163T2 (fr)
ME (1) ME03674B (fr)
MX (1) MX2018003256A (fr)
MY (1) MY188347A (fr)
NI (1) NI201800040A (fr)
PE (1) PE20181007A1 (fr)
PH (1) PH12018500569A1 (fr)
PL (1) PL3350163T3 (fr)
PT (1) PT3350163T (fr)
RS (1) RS60039B1 (fr)
SI (1) SI3350163T1 (fr)
TW (1) TWI758256B (fr)
UA (1) UA123672C2 (fr)
UY (1) UY36904A (fr)
WO (1) WO2017046258A1 (fr)
ZA (1) ZA201801764B (fr)

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KR102625991B1 (ko) 2017-05-22 2024-01-16 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체

Also Published As

Publication number Publication date
RS60039B1 (sr) 2020-04-30
US20180256544A1 (en) 2018-09-13
WO2017046258A1 (fr) 2017-03-23
LT3350163T (lt) 2020-04-10
EP3350163B1 (fr) 2019-12-25
IL258031B (en) 2021-03-25
EA035679B1 (ru) 2020-07-24
PT3350163T (pt) 2020-03-23
PH12018500569A1 (en) 2018-09-17
CL2018000697A1 (es) 2018-07-06
TWI758256B (zh) 2022-03-21
ME03674B (fr) 2020-10-20
AU2016323535B2 (en) 2021-02-18
CA2996856C (fr) 2023-08-01
CR20180214A (es) 2018-05-14
MD3350163T2 (ro) 2020-06-30
UA123672C2 (uk) 2021-05-12
CN108368044B (zh) 2021-06-15
CO2018003369A2 (es) 2018-07-10
JP2021193092A (ja) 2021-12-23
HK1258320A1 (zh) 2019-11-08
CN108368044A (zh) 2018-08-03
CY1122792T1 (el) 2021-05-05
NI201800040A (es) 2018-07-24
TW201722912A (zh) 2017-07-01
SI3350163T1 (sl) 2020-07-31
PL3350163T3 (pl) 2020-08-24
DK3350163T3 (da) 2020-03-16
MX2018003256A (es) 2018-11-09
CA2996856A1 (fr) 2017-03-23
EP3350163A1 (fr) 2018-07-25
KR20180051563A (ko) 2018-05-16
UY36904A (es) 2017-03-31
JP7045984B2 (ja) 2022-04-01
ECSP18020039A (es) 2018-04-30
IL258031A (en) 2018-05-31
US10786484B2 (en) 2020-09-29
HRP20200408T1 (hr) 2020-06-12
JP2018528222A (ja) 2018-09-27
AU2016323535A1 (en) 2018-03-08
EA201890723A1 (ru) 2018-08-31
KR102676442B1 (ko) 2024-06-18
MA42811A (fr) 2018-07-25
ES2778431T3 (es) 2020-08-10
PE20181007A1 (es) 2018-06-26
ZA201801764B (en) 2021-04-28
MY188347A (en) 2021-12-02
JO3633B1 (ar) 2020-08-27

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