MA42811A - Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents
Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengueInfo
- Publication number
- MA42811A MA42811A MA042811A MA42811A MA42811A MA 42811 A MA42811 A MA 42811A MA 042811 A MA042811 A MA 042811A MA 42811 A MA42811 A MA 42811A MA 42811 A MA42811 A MA 42811A
- Authority
- MA
- Morocco
- Prior art keywords
- monosubstituted
- compounds
- dengue virus
- virus replication
- indole derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La présente invention concerne des composés indoles mono- ou di-substitués, des procédés pour prévenir ou traiter les infections virales de la dengue en utilisant lesdits composés et concerne également lesdits composés à utiliser comme médicament, plus préférablement à utiliser comme médicament pour traiter ou prévenir la dengue virale infections. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations destinées à être utilisées comme médicament, plus préférablement pour la prévention ou le traitement des infections virales de la dengue. L'invention concerne également des procédés de préparation des composés.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15185522 | 2015-09-16 | ||
EP16163465 | 2016-04-01 | ||
PCT/EP2016/071852 WO2017046258A1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Publications (2)
Publication Number | Publication Date |
---|---|
MA42811A true MA42811A (fr) | 2018-07-25 |
MA42811B1 MA42811B1 (fr) | 2020-03-31 |
Family
ID=56958913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA42811A MA42811B1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Country Status (37)
Country | Link |
---|---|
US (1) | US10786484B2 (fr) |
EP (1) | EP3350163B1 (fr) |
JP (2) | JP7045984B2 (fr) |
KR (1) | KR20180051563A (fr) |
CN (1) | CN108368044B (fr) |
AU (1) | AU2016323535B2 (fr) |
CA (1) | CA2996856C (fr) |
CL (1) | CL2018000697A1 (fr) |
CO (1) | CO2018003369A2 (fr) |
CR (1) | CR20180214A (fr) |
CY (1) | CY1122792T1 (fr) |
DK (1) | DK3350163T3 (fr) |
EA (1) | EA035679B1 (fr) |
EC (1) | ECSP18020039A (fr) |
ES (1) | ES2778431T3 (fr) |
HK (1) | HK1258320A1 (fr) |
HR (1) | HRP20200408T1 (fr) |
IL (1) | IL258031B (fr) |
JO (1) | JO3633B1 (fr) |
LT (1) | LT3350163T (fr) |
MA (1) | MA42811B1 (fr) |
MD (1) | MD3350163T2 (fr) |
ME (1) | ME03674B (fr) |
MX (1) | MX2018003256A (fr) |
MY (1) | MY188347A (fr) |
NI (1) | NI201800040A (fr) |
PE (1) | PE20181007A1 (fr) |
PH (1) | PH12018500569A1 (fr) |
PL (1) | PL3350163T3 (fr) |
PT (1) | PT3350163T (fr) |
RS (1) | RS60039B1 (fr) |
SI (1) | SI3350163T1 (fr) |
TW (1) | TWI758256B (fr) |
UA (1) | UA123672C2 (fr) |
UY (1) | UY36904A (fr) |
WO (1) | WO2017046258A1 (fr) |
ZA (1) | ZA201801764B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
KR101818521B1 (ko) * | 2011-11-16 | 2018-01-16 | 대우조선해양 주식회사 | 마이크로채널 열교환기용 2상 유체 공급장치 및 그 방법 |
GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
PE20220507A1 (es) | 2015-12-16 | 2022-04-07 | Loxo Oncology Inc | Compuestos utiles como inhibidores de cinasa |
MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
WO2017167953A1 (fr) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
BR112018068956A2 (pt) | 2016-04-01 | 2019-01-22 | Janssen Pharmaceuticals Inc | derivados do composto indol substituídos como inibidores da replicação viral da dengue |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
WO2003050295A2 (fr) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Essais et mises en oeuvre permettant de determiner et de moduler une activite de liaison hsp90 |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
JP2008526980A (ja) | 2005-01-14 | 2008-07-24 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染症を治療するためのインドール誘導体 |
US20060194835A1 (en) | 2005-02-09 | 2006-08-31 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
CA2726985A1 (fr) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Inhibiteurs a petites molecules pour le traitement et la prevention de l'infection par le virus de la dengue |
AU2009283195A1 (en) * | 2008-08-18 | 2010-02-25 | Yale University | MIF modulators |
US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
PT2523951E (pt) | 2010-01-15 | 2015-09-14 | Gilead Sciences Inc | Inibidores de vírus flaviviridae |
JP5716205B2 (ja) * | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
GB201305376D0 (en) * | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
MX368158B (es) * | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
JP6464176B2 (ja) | 2014-01-31 | 2019-02-06 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 芳香族p2’基を有する第xia因子阻害剤としてのマクロ環 |
ME03344B (fr) | 2014-10-01 | 2019-10-20 | Janssen Pharmaceuticals Inc | Indoles monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
SG11201702463YA (en) | 2014-10-01 | 2017-04-27 | Janssen Pharmaceuticals Inc | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
NO2721243T3 (fr) | 2014-10-01 | 2018-10-20 | ||
JOP20150335B1 (ar) * | 2015-01-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
EP3370698B1 (fr) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Composites de polymère sol-gel et utilisation de ces derniers |
BR112018068538B1 (pt) | 2016-03-31 | 2023-12-12 | Takeda Pharmaceutical Company Limited | Composto, medicamento, e, uso de um composto |
WO2017167953A1 (fr) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
MX2018011784A (es) | 2016-03-31 | 2019-02-13 | Janssen Pharmaceuticals Inc | Derivados de indol sustituidos como inhibidores de la replicacion virica del dengue. |
UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
BR112018068956A2 (pt) | 2016-04-01 | 2019-01-22 | Janssen Pharmaceuticals Inc | derivados do composto indol substituídos como inibidores da replicação viral da dengue |
IL296966A (en) | 2016-04-01 | 2022-12-01 | Amgen Inc | Chimeric flt-3 receptors and methods of using them |
CN113150170A (zh) | 2016-04-01 | 2021-07-23 | 凯德药业股份有限公司 | 嵌合受体及其方法和用途 |
JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
EA039392B1 (ru) | 2016-04-01 | 2022-01-21 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способ лечения рака с применением замещенного аминопуринового соединения |
TW202313671A (zh) | 2016-04-01 | 2023-04-01 | 美商凱特製藥公司 | 嵌合抗原和t細胞受體及使用方法 |
JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
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2016
- 2016-09-06 JO JOP/2016/0197A patent/JO3633B1/ar active
- 2016-09-13 TW TW105129691A patent/TWI758256B/zh active
- 2016-09-15 ME MEP-2020-53A patent/ME03674B/fr unknown
- 2016-09-15 DK DK16767235.1T patent/DK3350163T3/da active
- 2016-09-15 ES ES16767235T patent/ES2778431T3/es active Active
- 2016-09-15 CN CN201680053589.9A patent/CN108368044B/zh active Active
- 2016-09-15 JP JP2018513845A patent/JP7045984B2/ja active Active
- 2016-09-15 WO PCT/EP2016/071852 patent/WO2017046258A1/fr active Application Filing
- 2016-09-15 RS RS20200272A patent/RS60039B1/sr unknown
- 2016-09-15 PT PT167672351T patent/PT3350163T/pt unknown
- 2016-09-15 KR KR1020187009485A patent/KR20180051563A/ko active IP Right Grant
- 2016-09-15 UA UAA201804016A patent/UA123672C2/uk unknown
- 2016-09-15 CR CR20180214A patent/CR20180214A/es unknown
- 2016-09-15 MX MX2018003256A patent/MX2018003256A/es unknown
- 2016-09-15 MY MYPI2018000378A patent/MY188347A/en unknown
- 2016-09-15 EA EA201890723A patent/EA035679B1/ru not_active IP Right Cessation
- 2016-09-15 MA MA42811A patent/MA42811B1/fr unknown
- 2016-09-15 US US15/759,844 patent/US10786484B2/en active Active
- 2016-09-15 LT LTEP16767235.1T patent/LT3350163T/lt unknown
- 2016-09-15 PL PL16767235T patent/PL3350163T3/pl unknown
- 2016-09-15 CA CA2996856A patent/CA2996856C/fr active Active
- 2016-09-15 AU AU2016323535A patent/AU2016323535B2/en active Active
- 2016-09-15 PE PE2018000391A patent/PE20181007A1/es unknown
- 2016-09-15 EP EP16767235.1A patent/EP3350163B1/fr active Active
- 2016-09-15 MD MDE20180704T patent/MD3350163T2/ro unknown
- 2016-09-15 SI SI201630686T patent/SI3350163T1/sl unknown
- 2016-09-16 UY UY0001036904A patent/UY36904A/es not_active Application Discontinuation
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2018
- 2018-03-12 IL IL258031A patent/IL258031B/en active IP Right Grant
- 2018-03-14 EC ECIEPI201820039A patent/ECSP18020039A/es unknown
- 2018-03-15 ZA ZA2018/01764A patent/ZA201801764B/en unknown
- 2018-03-15 NI NI201800040A patent/NI201800040A/es unknown
- 2018-03-15 CL CL2018000697A patent/CL2018000697A1/es unknown
- 2018-03-15 PH PH12018500569A patent/PH12018500569A1/en unknown
- 2018-03-26 CO CONC2018/0003369A patent/CO2018003369A2/es unknown
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2019
- 2019-01-16 HK HK19100688.6A patent/HK1258320A1/zh not_active IP Right Cessation
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2020
- 2020-03-12 HR HRP20200408TT patent/HRP20200408T1/hr unknown
- 2020-03-12 CY CY20201100216T patent/CY1122792T1/el unknown
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2021
- 2021-08-20 JP JP2021135171A patent/JP2021193092A/ja active Pending
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