MA42811A - Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents
Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengueInfo
- Publication number
- MA42811A MA42811A MA042811A MA42811A MA42811A MA 42811 A MA42811 A MA 42811A MA 042811 A MA042811 A MA 042811A MA 42811 A MA42811 A MA 42811A MA 42811 A MA42811 A MA 42811A
- Authority
- MA
- Morocco
- Prior art keywords
- monosubstituted
- compounds
- dengue virus
- virus replication
- indole derivatives
- Prior art date
Links
- 241000725619 Dengue virus Species 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000001490 Dengue Diseases 0.000 abstract 3
- 206010012310 Dengue fever Diseases 0.000 abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 208000025729 dengue disease Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- -1 di-substituted indole compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des composés indoles mono- ou di-substitués, des procédés pour prévenir ou traiter les infections virales de la dengue en utilisant lesdits composés et concerne également lesdits composés à utiliser comme médicament, plus préférablement à utiliser comme médicament pour traiter ou prévenir la dengue virale infections. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations destinées à être utilisées comme médicament, plus préférablement pour la prévention ou le traitement des infections virales de la dengue. L'invention concerne également des procédés de préparation des composés.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185522 | 2015-09-16 | ||
| EP16163465 | 2016-04-01 | ||
| PCT/EP2016/071852 WO2017046258A1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA42811A true MA42811A (fr) | 2018-07-25 |
| MA42811B1 MA42811B1 (fr) | 2020-03-31 |
Family
ID=56958913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA42811A MA42811B1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US10786484B2 (fr) |
| EP (1) | EP3350163B1 (fr) |
| JP (2) | JP7045984B2 (fr) |
| KR (1) | KR102676442B1 (fr) |
| CN (1) | CN108368044B (fr) |
| AU (1) | AU2016323535B2 (fr) |
| CA (1) | CA2996856C (fr) |
| CL (1) | CL2018000697A1 (fr) |
| CO (1) | CO2018003369A2 (fr) |
| CR (1) | CR20180214A (fr) |
| CY (1) | CY1122792T1 (fr) |
| DK (1) | DK3350163T3 (fr) |
| EA (1) | EA035679B1 (fr) |
| EC (1) | ECSP18020039A (fr) |
| ES (1) | ES2778431T3 (fr) |
| HR (1) | HRP20200408T1 (fr) |
| IL (1) | IL258031B (fr) |
| JO (1) | JO3633B1 (fr) |
| LT (1) | LT3350163T (fr) |
| MA (1) | MA42811B1 (fr) |
| MD (1) | MD3350163T2 (fr) |
| ME (1) | ME03674B (fr) |
| MX (1) | MX381632B (fr) |
| MY (1) | MY188347A (fr) |
| NI (1) | NI201800040A (fr) |
| PE (1) | PE20181007A1 (fr) |
| PH (1) | PH12018500569B1 (fr) |
| PL (1) | PL3350163T3 (fr) |
| PT (1) | PT3350163T (fr) |
| RS (1) | RS60039B1 (fr) |
| SI (1) | SI3350163T1 (fr) |
| SM (1) | SMT202000140T1 (fr) |
| TW (1) | TWI758256B (fr) |
| UA (1) | UA123672C2 (fr) |
| UY (1) | UY36904A (fr) |
| WO (1) | WO2017046258A1 (fr) |
| ZA (1) | ZA201801764B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR101818521B1 (ko) * | 2011-11-16 | 2018-01-16 | 대우조선해양 주식회사 | 마이크로채널 열교환기용 2상 유체 공급장치 및 그 방법 |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| UA127863C2 (uk) | 2015-12-16 | 2024-01-31 | Локсо Онколоджі, Інк. | Сполуки, які можна застосовувати як інгібітори кінази |
| CR20180496A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| WO2017167950A1 (fr) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX393586B (es) | 2017-05-22 | 2025-03-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| WO2024178504A1 (fr) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Dérivés de tryptamine à substitution tri-halo-alcoxy et procédés d'utilisation |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| WO2003050295A2 (fr) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Essais et mises en oeuvre permettant de determiner et de moduler une activite de liaison hsp90 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| AU2006204917A1 (en) | 2005-01-14 | 2006-07-20 | Smithkline Beecham Corporation | Indole derivatives for treating viral infections |
| EA200701669A1 (ru) | 2005-02-09 | 2008-02-28 | Мидженикс Инк. | Композиции и способы лечения или предотвращения инфекций, вызванных вирусами семейства flaviviridae |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| CA2733554A1 (fr) * | 2008-08-18 | 2010-02-25 | Yale University | Modulateurs de mif |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| PT2523951E (pt) | 2010-01-15 | 2015-09-14 | Gilead Sciences Inc | Inibidores de vírus flaviviridae |
| JP5716205B2 (ja) * | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JP6030035B2 (ja) * | 2013-09-27 | 2016-11-24 | 富士フイルム株式会社 | 蛍光観察装置、内視鏡システム及びプロセッサ装置並びに作動方法 |
| KR102290189B1 (ko) * | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| TWI688564B (zh) | 2014-01-31 | 2020-03-21 | 美商必治妥美雅史谷比公司 | 作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物 |
| PL3201177T3 (pl) | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals Inc | Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi |
| NO2721243T3 (fr) | 2014-10-01 | 2018-10-20 | ||
| EP3201176B1 (fr) | 2014-10-01 | 2018-12-12 | Janssen Pharmaceuticals, Inc. | Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue |
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3370698B1 (fr) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Composites de polymère sol-gel et utilisation de ces derniers |
| WO2017167950A1 (fr) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| CR20180496A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| EA036637B1 (ru) | 2016-03-31 | 2020-12-02 | Такеда Фармасьютикал Компани Лимитед | Гетероциклические спиросоединения, ингибирующие моноацилглицерин-липазу |
| CA3015934A1 (fr) | 2016-04-01 | 2017-10-05 | Basf Se | Composes bicycliques |
| CN109069482B (zh) | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| PT3436079T (pt) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| UA123276C2 (uk) | 2016-04-01 | 2021-03-10 | Кайт Фарма, Інк. | Химерний рецептор та спосіб лікування пухлини або злоякісного новоутворення |
| BR112018070163A2 (pt) | 2016-04-01 | 2019-01-29 | Signal Pharm Llc | compostos de aminopurina substituída, composições e métodos de tratamento |
| KR102694879B1 (ko) | 2016-04-01 | 2024-08-16 | 암젠 인크 | Flt3에 대한 키메라 수용체 및 이의 사용 방법 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| PE20200342A1 (es) | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| MX393586B (es) | 2017-05-22 | 2025-03-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
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2016
- 2016-09-06 JO JOP/2016/0197A patent/JO3633B1/ar active
- 2016-09-13 TW TW105129691A patent/TWI758256B/zh not_active IP Right Cessation
- 2016-09-15 ES ES16767235T patent/ES2778431T3/es active Active
- 2016-09-15 CN CN201680053589.9A patent/CN108368044B/zh active Active
- 2016-09-15 MD MDE20180704T patent/MD3350163T2/ro unknown
- 2016-09-15 PH PH1/2018/500569A patent/PH12018500569B1/en unknown
- 2016-09-15 MA MA42811A patent/MA42811B1/fr unknown
- 2016-09-15 CA CA2996856A patent/CA2996856C/fr active Active
- 2016-09-15 SI SI201630686T patent/SI3350163T1/sl unknown
- 2016-09-15 DK DK16767235.1T patent/DK3350163T3/da active
- 2016-09-15 ME MEP-2020-53A patent/ME03674B/fr unknown
- 2016-09-15 KR KR1020187009485A patent/KR102676442B1/ko active Active
- 2016-09-15 RS RS20200272A patent/RS60039B1/sr unknown
- 2016-09-15 HR HRP20200408TT patent/HRP20200408T1/hr unknown
- 2016-09-15 JP JP2018513845A patent/JP7045984B2/ja active Active
- 2016-09-15 LT LTEP16767235.1T patent/LT3350163T/lt unknown
- 2016-09-15 PE PE2018000391A patent/PE20181007A1/es unknown
- 2016-09-15 PL PL16767235T patent/PL3350163T3/pl unknown
- 2016-09-15 EP EP16767235.1A patent/EP3350163B1/fr active Active
- 2016-09-15 UA UAA201804016A patent/UA123672C2/uk unknown
- 2016-09-15 EA EA201890723A patent/EA035679B1/ru not_active IP Right Cessation
- 2016-09-15 PT PT167672351T patent/PT3350163T/pt unknown
- 2016-09-15 MY MYPI2018000378A patent/MY188347A/en unknown
- 2016-09-15 US US15/759,844 patent/US10786484B2/en active Active
- 2016-09-15 CR CR20180214A patent/CR20180214A/es unknown
- 2016-09-15 WO PCT/EP2016/071852 patent/WO2017046258A1/fr not_active Ceased
- 2016-09-15 AU AU2016323535A patent/AU2016323535B2/en active Active
- 2016-09-15 MX MX2018003256A patent/MX381632B/es unknown
- 2016-09-15 SM SM20200140T patent/SMT202000140T1/it unknown
- 2016-09-16 UY UY0001036904A patent/UY36904A/es not_active Application Discontinuation
-
2018
- 2018-03-12 IL IL258031A patent/IL258031B/en active IP Right Grant
- 2018-03-14 EC ECIEPI201820039A patent/ECSP18020039A/es unknown
- 2018-03-15 ZA ZA2018/01764A patent/ZA201801764B/en unknown
- 2018-03-15 NI NI201800040A patent/NI201800040A/es unknown
- 2018-03-15 CL CL2018000697A patent/CL2018000697A1/es unknown
- 2018-03-26 CO CONC2018/0003369A patent/CO2018003369A2/es unknown
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2020
- 2020-03-12 CY CY20201100216T patent/CY1122792T1/el unknown
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2021
- 2021-08-20 JP JP2021135171A patent/JP2021193092A/ja active Pending
Also Published As
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