MX2021015433A - Vectores ad35 recombinantes y mejoras de la terapia génica relacionadas. - Google Patents

Vectores ad35 recombinantes y mejoras de la terapia génica relacionadas.

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Publication number
MX2021015433A
MX2021015433A MX2021015433A MX2021015433A MX2021015433A MX 2021015433 A MX2021015433 A MX 2021015433A MX 2021015433 A MX2021015433 A MX 2021015433A MX 2021015433 A MX2021015433 A MX 2021015433A MX 2021015433 A MX2021015433 A MX 2021015433A
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MX
Mexico
Prior art keywords
helper
vectors
dependent
gene therapy
recombinant
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MX2021015433A
Other languages
English (en)
Inventor
Andre Lieber
Hongjie Wang
Hans - Peter Kiem
Chang Li
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Hutchinson Fred Cancer Res
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Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of MX2021015433A publication Critical patent/MX2021015433A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/50—Vectors for producing vectors
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae
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    • C12N2999/00—Further aspects of viruses or vectors not covered by groups C12N2710/00 - C12N2796/00 or C12N2800/00
    • C12N2999/007—Technological advancements, e.g. new system for producing known virus, cre-lox system for production of transgenic animals

Abstract

La presente descripción proporciona, entre otras cosas, vectores adenovirales dependientes del auxiliar serotipo 35 (Ad35). En diversas modalidades, los vectores Ad35 dependientes del auxiliar pueden usare para administrar una carga útil terapéutica a un sujeto que lo necesite. Las cargas útiles ilustrativas pueden codificar proteínas de reemplazo, anticuerpos, CAR, TCR, ARN pequeños y sistemas de edición genómica En determinadas modalidades, un vector Ad35 dependiente del auxiliar se modifica genéticamente para la integración de una carga útil en un genoma de célula hospedadora. La presente descripción incluye además métodos de terapia génica que incluyen la administración de un vector Ad35 dependiente del auxiliar a un sujeto que lo necesite.
MX2021015433A 2019-07-02 2020-07-02 Vectores ad35 recombinantes y mejoras de la terapia génica relacionadas. MX2021015433A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962869907P 2019-07-02 2019-07-02
US201962935507P 2019-11-14 2019-11-14
US202063009385P 2020-04-13 2020-04-13
PCT/US2020/040756 WO2021003432A1 (en) 2019-07-02 2020-07-02 Recombinant ad35 vectors and related gene therapy improvements

Publications (1)

Publication Number Publication Date
MX2021015433A true MX2021015433A (es) 2022-06-08

Family

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MX2021015433A MX2021015433A (es) 2019-07-02 2020-07-02 Vectores ad35 recombinantes y mejoras de la terapia génica relacionadas.

Country Status (12)

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US (1) US20220257796A1 (es)
EP (1) EP3994270A1 (es)
JP (1) JP2022539248A (es)
KR (1) KR20220038362A (es)
CN (1) CN114729383A (es)
AU (1) AU2020298572A1 (es)
BR (1) BR112021026832A2 (es)
CA (1) CA3138188A1 (es)
IL (1) IL289518A (es)
MX (1) MX2021015433A (es)
SG (1) SG11202111943UA (es)
WO (1) WO2021003432A1 (es)

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CN113755447B (zh) * 2021-09-23 2022-04-29 云舟生物科技(广州)股份有限公司 一种用于生产腺病毒的293a细胞株及其制备与应用
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