MX2020000221A - Secuencias de aminoacidos y de acidos nucleicos de adenovirus de grandes simios no humanos, vectores que contienen las mismas y usos de las mismas. - Google Patents
Secuencias de aminoacidos y de acidos nucleicos de adenovirus de grandes simios no humanos, vectores que contienen las mismas y usos de las mismas.Info
- Publication number
- MX2020000221A MX2020000221A MX2020000221A MX2020000221A MX2020000221A MX 2020000221 A MX2020000221 A MX 2020000221A MX 2020000221 A MX2020000221 A MX 2020000221A MX 2020000221 A MX2020000221 A MX 2020000221A MX 2020000221 A MX2020000221 A MX 2020000221A
- Authority
- MX
- Mexico
- Prior art keywords
- sequences
- novel
- amino acid
- virus
- strains
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title abstract 5
- 239000013598 vector Substances 0.000 title abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 230000036039 immunity Effects 0.000 abstract 2
- 108090000565 Capsid Proteins Proteins 0.000 abstract 1
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10323—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a nuevas cepas de adenovirus con una alta inmunogenicidad y sin inmunidad preexistente en la población humana general. La falta de inmunidad preexistente se debe a nuevas regiones hipervariables en la proteína del hexón de la cápside adenoviral. Las nuevas cepas de adenovirus también tienen una capacidad mejorada para la reproducción. La presente invención proporciona secuencias de nucleótidos y aminoácidos de estas nuevas cepas de adenovirus, así como virus recombinantes, partículas tipo virus y vectores basados en estas cepas. Además, se proporcionan composiciones farmacéuticas y usos médicos en la terapia o profilaxis de una enfermedad, y métodos para producir un adenovirus o partículas tipo virus utilizando las nuevas secuencias, virus recombinantes, partículas tipo virus y vectores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17179825 | 2017-07-05 | ||
| PCT/EP2018/068291 WO2019008111A1 (en) | 2017-07-05 | 2018-07-05 | AMINO ACID AND NUCLEIC ACID SEQUENCES OF ADENOVIRUS OF NON-HUMAN GREEN APES, VECTORS CONTAINING SAME, AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020000221A true MX2020000221A (es) | 2020-08-13 |
Family
ID=59295008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020000221A MX2020000221A (es) | 2017-07-05 | 2018-07-05 | Secuencias de aminoacidos y de acidos nucleicos de adenovirus de grandes simios no humanos, vectores que contienen las mismas y usos de las mismas. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11098324B2 (es) |
| EP (1) | EP3649237B1 (es) |
| JP (1) | JP7274222B2 (es) |
| KR (1) | KR102582561B1 (es) |
| CN (1) | CN111108192B (es) |
| AU (1) | AU2018295421B2 (es) |
| BR (1) | BR112020000145A2 (es) |
| CA (1) | CA3066962A1 (es) |
| DK (1) | DK3649237T3 (es) |
| ES (1) | ES2906441T3 (es) |
| HU (1) | HUE058778T2 (es) |
| IL (1) | IL271835B2 (es) |
| MX (1) | MX2020000221A (es) |
| PL (1) | PL3649237T3 (es) |
| PT (1) | PT3649237T (es) |
| RU (1) | RU2762854C2 (es) |
| SG (1) | SG11201913178WA (es) |
| WO (1) | WO2019008111A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3587581A1 (en) | 2018-06-26 | 2020-01-01 | GlaxoSmithKline Biologicals S.A. | Formulations for simian adenoviral vectors having enhanced storage stability |
| TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| IL293051A (en) | 2019-11-18 | 2022-07-01 | Janssen Biotech Inc | calr and jak2 mutant-based vaccines and their uses |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| AU2021226304A1 (en) | 2020-02-27 | 2022-08-04 | Amorepacific Corporation | Composition having improved usability |
| WO2021209897A1 (en) | 2020-04-13 | 2021-10-21 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
| WO2021229473A1 (en) | 2020-05-14 | 2021-11-18 | Glaxosmithkline Biologicals Sa | Viral biosensors |
| TW202208398A (zh) * | 2020-07-01 | 2022-03-01 | 義大利商萊伊錫拉有限責任公司 | 大猩猩腺病毒核酸及胺基酸序列，包含彼之載體，及其用途 |
| EP4175721A1 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022009052A2 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| EP4177347A1 (en) * | 2020-07-06 | 2023-05-10 | Jiaxing Anyu Biotechnology Co., Ltd | Novel chimpanzee adenovirus vector, construction method therefor, and application thereof |
| US20230035403A1 (en) | 2020-07-06 | 2023-02-02 | Janssen Biotech, Inc. | Method For Determining Responsiveness To Prostate Cancer Treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69534166T2 (de) | 1994-10-28 | 2006-03-09 | Trustees Of The University Of Pennsylvania | Rekombinanter adenovirus und methoden zu dessen verwendung |
| US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| US20030224372A1 (en) | 2002-05-31 | 2003-12-04 | Denise Syndercombe-Court | Method for determining ethnic origin by means of STR profile |
| PL1711518T3 (pl) | 2004-01-23 | 2010-06-30 | St Di Richerche Di Biologia Molecolare P Angeletti S P A | Nośniki szczepionek pochodzące od szympansich adenowirusów |
| WO2006040330A2 (en) * | 2004-10-13 | 2006-04-20 | Crucell Holland B.V. | Improved adenoviral vectors and uses thereof |
| DE602005025512D1 (de) * | 2004-10-13 | 2011-02-03 | Crucell Holland Bv | Verbesserte adenovirusvektoren und deren verwendung |
| CA2597404A1 (en) | 2005-02-11 | 2006-08-17 | Merck & Co. Inc. | Adenovirus serotype 26 vectors, nucleic acid and viruses produced thereby |
| JP5809978B2 (ja) | 2008-10-31 | 2015-11-11 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | サルアデノウイルスＳＡｄＶ−４３、−４５、−４６、−４７、−４８、−４９および−５０ならびにそれらの用途 |
| BRPI1008018A2 (pt) * | 2009-02-02 | 2016-03-15 | Okairos Ag | ácidos nucleicos de adenovírus símio e sequências de aminoácidos, vetores contendo os mesmos e uso dos mesmos |
| WO2010085984A1 (en) * | 2009-02-02 | 2010-08-05 | Okairos Ag | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
| WO2012023995A1 (en) * | 2010-08-18 | 2012-02-23 | Takayuki Shiratsuchi | Modification of recombinant adenovirus capsid protein with immunogenic plasmodium circumsporozoite protein epitopes |
| WO2013036791A2 (en) * | 2011-09-09 | 2013-03-14 | Beth Israel Deaconess Medical Center, Inc. | Modified adenoviral vectors and methods of treatment using same |
| IN2014DN03005A (es) | 2011-10-05 | 2015-05-08 | Genvec Inc | |
| EP2809346A1 (en) | 2012-02-02 | 2014-12-10 | GenVec, Inc. | Adenoviral vector-based malaria vaccine |
| CN103966263A (zh) * | 2013-02-04 | 2014-08-06 | 广州医学院第一附属医院 | 一种重组人3型腺病毒及其制备方法和应用 |
| CN104419717B (zh) * | 2013-08-23 | 2018-04-27 | 长春百克生物科技股份公司 | 逃避预存免疫的重组腺病毒及其构建方法和用途 |
| WO2019118480A1 (en) * | 2017-12-11 | 2019-06-20 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and uses thereof |
| TW202208398A (zh) * | 2020-07-01 | 2022-03-01 | 義大利商萊伊錫拉有限責任公司 | 大猩猩腺病毒核酸及胺基酸序列，包含彼之載體，及其用途 |
-
2018
- 2018-07-05 CN CN201880045366.7A patent/CN111108192B/zh active Active
- 2018-07-05 RU RU2019144161A patent/RU2762854C2/ru active
- 2018-07-05 BR BR112020000145-7A patent/BR112020000145A2/pt unknown
- 2018-07-05 JP JP2020500165A patent/JP7274222B2/ja active Active
- 2018-07-05 ES ES18737898T patent/ES2906441T3/es active Active
- 2018-07-05 HU HUE18737898A patent/HUE058778T2/hu unknown
- 2018-07-05 PT PT187378989T patent/PT3649237T/pt unknown
- 2018-07-05 WO PCT/EP2018/068291 patent/WO2019008111A1/en unknown
- 2018-07-05 CA CA3066962A patent/CA3066962A1/en active Pending
- 2018-07-05 EP EP18737898.9A patent/EP3649237B1/en active Active
- 2018-07-05 SG SG11201913178WA patent/SG11201913178WA/en unknown
- 2018-07-05 US US16/626,438 patent/US11098324B2/en active Active
- 2018-07-05 KR KR1020207003223A patent/KR102582561B1/ko active IP Right Grant
- 2018-07-05 MX MX2020000221A patent/MX2020000221A/es unknown
- 2018-07-05 DK DK18737898.9T patent/DK3649237T3/da active
- 2018-07-05 AU AU2018295421A patent/AU2018295421B2/en active Active
- 2018-07-05 PL PL18737898T patent/PL3649237T3/pl unknown
-
2020
- 2020-01-05 IL IL271835A patent/IL271835B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020530761A (ja) | 2020-10-29 |
| JP7274222B2 (ja) | 2023-05-16 |
| KR102582561B1 (ko) | 2023-09-26 |
| EP3649237B1 (en) | 2022-01-19 |
| CA3066962A1 (en) | 2019-01-10 |
| RU2762854C2 (ru) | 2021-12-23 |
| SG11201913178WA (en) | 2020-01-30 |
| AU2018295421A1 (en) | 2020-01-02 |
| IL271835B2 (en) | 2023-08-01 |
| DK3649237T3 (da) | 2022-02-21 |
| PL3649237T3 (pl) | 2022-03-28 |
| US11098324B2 (en) | 2021-08-24 |
| CN111108192B (zh) | 2023-12-15 |
| RU2019144161A3 (es) | 2021-08-05 |
| US20210130848A1 (en) | 2021-05-06 |
| PT3649237T (pt) | 2022-02-14 |
| EP3649237A1 (en) | 2020-05-13 |
| HUE058778T2 (hu) | 2022-09-28 |
| KR20200024296A (ko) | 2020-03-06 |
| BR112020000145A2 (pt) | 2020-07-14 |
| CN111108192A (zh) | 2020-05-05 |
| AU2018295421B2 (en) | 2024-01-25 |
| IL271835B1 (en) | 2023-04-01 |
| NZ759892A (en) | 2023-09-29 |
| RU2019144161A (ru) | 2021-08-05 |
| ES2906441T3 (es) | 2022-04-18 |
| IL271835A (en) | 2020-02-27 |
| WO2019008111A1 (en) | 2019-01-10 |
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