EA200702190A1 - Вакцинная композиция - Google Patents
Вакцинная композицияInfo
- Publication number
- EA200702190A1 EA200702190A1 EA200702190A EA200702190A EA200702190A1 EA 200702190 A1 EA200702190 A1 EA 200702190A1 EA 200702190 A EA200702190 A EA 200702190A EA 200702190 A EA200702190 A EA 200702190A EA 200702190 A1 EA200702190 A1 EA 200702190A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- adenoviruses
- relates
- hiv
- vectors
- viral vectors
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 5
- 241000701161 unidentified adenovirus Species 0.000 abstract 4
- 239000013603 viral vector Substances 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 241001217856 Chimpanzee adenovirus Species 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- AIDS & HIV (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к вирусным векторам, содержащим олигонуклеотиды, кодирующие полипептиды вируса иммунодефицита человека (HIV), более конкретно, где вирусный вектор представляет собой аденовирус. В частности, такие аденовирусы представляют собой аденовирусы приматов, отличных от человека, такие как аденовирусы обезьян, более конкретно аденовирусы шимпанзе. В частности, изобретение относится к аденовирусным векторам, которые содержат полинуклеотидные последовательности HIV, которые кодируют множество различных антигенов HIV, например два, или три, или более антигенов HIV. Изобретение также относится к способам получения вирусных векторов, к вирусным векторам, получаемым этими способами, и к применению векторов в медицине, в особенности профилактической или терапевтической вакцинации.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68038905P | 2005-05-12 | 2005-05-12 | |
PCT/EP2006/004854 WO2006120034A1 (en) | 2005-05-12 | 2006-05-10 | Vaccine composition |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200702190A1 true EA200702190A1 (ru) | 2008-04-28 |
Family
ID=36954770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200702190A EA200702190A1 (ru) | 2005-05-12 | 2006-05-10 | Вакцинная композиция |
Country Status (20)
Country | Link |
---|---|
US (1) | US20090208515A1 (ru) |
EP (1) | EP1880012B1 (ru) |
JP (2) | JP5175178B2 (ru) |
KR (1) | KR101451620B1 (ru) |
CN (2) | CN101384722A (ru) |
AR (1) | AR053275A1 (ru) |
AU (1) | AU2006245920A1 (ru) |
BR (1) | BRPI0608798A2 (ru) |
CA (1) | CA2608316A1 (ru) |
EA (1) | EA200702190A1 (ru) |
ES (1) | ES2546330T3 (ru) |
IL (1) | IL186828A (ru) |
MA (1) | MA29458B1 (ru) |
MX (1) | MX2007014038A (ru) |
NO (1) | NO20075648L (ru) |
PE (1) | PE20061372A1 (ru) |
SG (1) | SG182173A1 (ru) |
TW (1) | TW200716750A (ru) |
WO (1) | WO2006120034A1 (ru) |
ZA (1) | ZA200709518B (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ550416A (en) | 2001-11-21 | 2008-06-30 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
US20090246220A1 (en) | 2006-08-28 | 2009-10-01 | Ertl Hildegund C J | Constructs for enhancing immune responses |
US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
SI2137210T1 (sl) * | 2007-03-02 | 2017-01-31 | Glaxosmithkline Biologicals S.A. | Nov postopek in sestavki |
BRPI0822651A2 (pt) * | 2007-11-28 | 2014-10-14 | Univ Pennsylvania | Subfamília b de adenovírus sadv-28, -27, 29, -32, -33 e -35 de símio e seus usos |
CN101883858B (zh) * | 2007-11-28 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用 |
CN102016011B (zh) | 2008-03-04 | 2013-12-11 | 宾夕法尼亚大学托管会 | 猿猴腺病毒sadv-36、-42.1、-42.2和-44及其应用 |
CN105709221B (zh) | 2011-04-06 | 2020-11-17 | 拜欧瓦克西姆有限公司 | 用于预防和/或治疗人中的hiv疾病的药物组合物 |
AU2013231423B2 (en) | 2012-03-12 | 2018-10-04 | Janssen Vaccines & Prevention B.V. | Batches of recombinant adenovirus with altered terminal ends |
US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
AU2013262626B2 (en) | 2012-05-18 | 2018-11-29 | The Trustees Of The University Of Pennsylvania | Subfamily E simian adenoviruses A1302, A1320, A1331 and A1337 and uses thereof |
US9624510B2 (en) | 2013-03-01 | 2017-04-18 | The Wistar Institute | Adenoviral vectors comprising partial deletions of E3 |
SG10201804469RA (en) * | 2013-03-14 | 2018-06-28 | Amgen Inc | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
WO2016146844A1 (en) | 2015-03-18 | 2016-09-22 | Janssen Vaccines & Prevention B.V. | Assays for recombinant expression systems |
SI3283634T1 (sl) | 2015-04-14 | 2019-08-30 | Janssen Vaccines & Prevention B.V. | Rekombinantni adenovirus, ki izraža dva transgena z dvosmernim promotorjem |
CN107921118B (zh) * | 2015-06-12 | 2022-11-08 | 葛兰素史密丝克莱恩生物有限公司 | 腺病毒多核苷酸和多肽 |
US10343884B2 (en) | 2015-07-10 | 2019-07-09 | E. & J. Gallo Winery | System and method for dispensing a beverage |
CA3023322A1 (en) | 2016-05-12 | 2017-11-16 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
BR112018075969A2 (pt) | 2016-06-20 | 2019-04-02 | Janssen Vaccines & Prevention B.V. | promotor bidirecional potente e equilibrado |
EP3490610A4 (en) | 2016-08-01 | 2020-05-20 | The Wistar Institute Of Anatomy And Biology | DEFICIENTLY REPLICABLE ADENOVIRAL VECTOR COMPOSITIONS AND METHODS FOR VACCINE APPLICATIONS |
CN110268061A (zh) | 2017-02-09 | 2019-09-20 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4255397A (en) * | 1996-09-06 | 1998-03-26 | Trustees Of The University Of Pennsylvania, The | Chimpanzee adenovirus vectors |
WO2002022080A2 (en) * | 2000-09-15 | 2002-03-21 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
US6733993B2 (en) * | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
US20040241181A1 (en) * | 2001-06-22 | 2004-12-02 | Ertl Hildeghund C. J. | Methods of inducing a cytotoxic immune response and recormbinant simian adenovirus compositions useful therein |
MXPA04002631A (es) * | 2001-09-20 | 2004-07-08 | Glaxo Group Ltd | Vacunas de adn optimizadas por codon gag-vih. |
GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
GB0225788D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
CA2539864A1 (en) * | 2003-09-24 | 2005-04-07 | Oxxon Therapeutics Limited | Hiv pharmaccines |
GB0417494D0 (en) * | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
-
2006
- 2006-05-10 US US11/913,952 patent/US20090208515A1/en not_active Abandoned
- 2006-05-10 AR ARP060101875A patent/AR053275A1/es unknown
- 2006-05-10 CN CNA2006800162796A patent/CN101384722A/zh active Pending
- 2006-05-10 ES ES06743016.5T patent/ES2546330T3/es active Active
- 2006-05-10 SG SG2012041687A patent/SG182173A1/en unknown
- 2006-05-10 CN CN2013100023418A patent/CN103088060A/zh active Pending
- 2006-05-10 PE PE2006000493A patent/PE20061372A1/es not_active Application Discontinuation
- 2006-05-10 EA EA200702190A patent/EA200702190A1/ru unknown
- 2006-05-10 CA CA002608316A patent/CA2608316A1/en not_active Abandoned
- 2006-05-10 TW TW095116578A patent/TW200716750A/zh unknown
- 2006-05-10 AU AU2006245920A patent/AU2006245920A1/en not_active Abandoned
- 2006-05-10 EP EP06743016.5A patent/EP1880012B1/en active Active
- 2006-05-10 MX MX2007014038A patent/MX2007014038A/es active IP Right Grant
- 2006-05-10 JP JP2008510517A patent/JP5175178B2/ja not_active Expired - Fee Related
- 2006-05-10 BR BRPI0608798-1A patent/BRPI0608798A2/pt not_active IP Right Cessation
- 2006-05-10 WO PCT/EP2006/004854 patent/WO2006120034A1/en active Application Filing
- 2006-05-10 KR KR1020077029093A patent/KR101451620B1/ko not_active IP Right Cessation
-
2007
- 2007-10-22 IL IL186828A patent/IL186828A/en not_active IP Right Cessation
- 2007-11-05 ZA ZA2007/09518A patent/ZA200709518B/en unknown
- 2007-11-06 NO NO20075648A patent/NO20075648L/no not_active Application Discontinuation
- 2007-11-20 MA MA30386A patent/MA29458B1/fr unknown
-
2012
- 2012-08-24 JP JP2012185395A patent/JP2013046613A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2007014038A (es) | 2008-02-11 |
KR101451620B1 (ko) | 2014-10-21 |
AR053275A1 (es) | 2007-04-25 |
KR20080021659A (ko) | 2008-03-07 |
CA2608316A1 (en) | 2006-11-16 |
AU2006245920A1 (en) | 2006-11-16 |
SG182173A1 (en) | 2012-07-30 |
ZA200709518B (en) | 2014-01-29 |
MA29458B1 (fr) | 2008-05-02 |
PE20061372A1 (es) | 2007-01-16 |
EP1880012B1 (en) | 2015-07-08 |
CN101384722A (zh) | 2009-03-11 |
IL186828A0 (en) | 2008-02-09 |
JP2013046613A (ja) | 2013-03-07 |
ES2546330T3 (es) | 2015-09-22 |
NO20075648L (no) | 2008-02-07 |
IL186828A (en) | 2015-06-30 |
EP1880012A1 (en) | 2008-01-23 |
JP2008539746A (ja) | 2008-11-20 |
US20090208515A1 (en) | 2009-08-20 |
WO2006120034A8 (en) | 2007-11-15 |
BRPI0608798A2 (pt) | 2011-03-15 |
CN103088060A (zh) | 2013-05-08 |
JP5175178B2 (ja) | 2013-04-03 |
WO2006120034A1 (en) | 2006-11-16 |
TW200716750A (en) | 2007-05-01 |
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