SG10201804469RA - Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods - Google Patents

Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods

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Publication number
SG10201804469RA
SG10201804469RA SG10201804469RA SG10201804469RA SG10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA SG 10201804469R A SG10201804469R A SG 10201804469RA
Authority
SG
Singapore
Prior art keywords
variants
methods
timp
compositions
tissue inhibitor
Prior art date
Application number
SG10201804469RA
Inventor
Jeonghoon Sun
Jason O'neill
Randal Ketchem
Randy HECHT
Edward Belouski
Mark Michaels
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361782613P priority Critical
Priority to US201361798160P priority
Priority to US201361802988P priority
Priority to US201461940673P priority
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG10201804469RA publication Critical patent/SG10201804469RA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them. 5 No Suitable Figure
SG10201804469RA 2013-03-14 2014-03-13 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods SG10201804469RA (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US201361782613P true 2013-03-14 2013-03-14
US201361798160P true 2013-03-15 2013-03-15
US201361802988P true 2013-03-18 2013-03-18
US201461940673P true 2014-02-17 2014-02-17

Publications (1)

Publication Number Publication Date
SG10201804469RA true SG10201804469RA (en) 2018-06-28

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SG11201507524TA SG11201507524TA (en) 2013-03-14 2014-03-13 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
SG10201804469RA SG10201804469RA (en) 2013-03-14 2014-03-13 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods

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US (2) US10189890B2 (en)
EP (1) EP2970407A2 (en)
JP (2) JP2016513666A (en)
KR (1) KR20150126886A (en)
CN (2) CN105531285B (en)
AP (1) AP201508729A0 (en)
AU (3) AU2014236683B2 (en)
BR (1) BR112015022491A2 (en)
CA (1) CA2906053A1 (en)
CL (1) CL2015002663A1 (en)
EA (1) EA034200B1 (en)
HK (1) HK1219959A1 (en)
IL (1) IL241246A (en)
MX (1) MX2015012891A (en)
PE (1) PE20151894A1 (en)
PH (1) PH12015502059A1 (en)
SG (2) SG11201507524TA (en)
TN (1) TN2015000423A1 (en)
TW (3) TW202014435A (en)
WO (1) WO2014152012A2 (en)

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