KR20200024296A - 비인간 대형 유인원 아데노바이러스 핵산-서열 및 아미노산-서열, 이를 포함하는 벡터 및 그의 용도 - Google Patents

Abstract

본 발명은 일반적인 인구 집단에서 면역원성이 높고, 기 존재하는 면역이 부재하는 신규한 아데노바이러스 균주에 관한 것이다. 기 존재하는 면역의 부재는 아데노바이러스 캡시드 단백질 헥손의 신규한 초가변 영역에 기인한다. 신규한 아데노바이러스 균주는 또한 증식 능력이 향상되었다. 본 발명은 이들 균주를 기반으로 한 재조합 바이러스, 바이러스-유사 입자 및 벡터뿐만 아니라, 이들 신규 아데노바이러스 균주의 뉴클레오타이드 및 아미노산 서열을 제공한다. 약제학적 조성물 및 질병의 치료 또는 예방에서의 의학적 용도, 및 신규 서열, 재조합 바이러스, 바이러스-유사 입자 및 벡터를 사용하는 아데노바이러스 또는 바이러스-유사 입자의 제조 방법이 추가로 제공된다.

Description

비인간 대형 유인원 아데노바이러스 핵산-서열 및 아미노산-서열, 이를 포함하는 벡터 및 그의 용도

본 발명은 일반적인 인구 집단에서 면역원성이 높고, 기 존재하는 면역이 부재하는 신규 아데노바이러스 균주에 관한 것이다. 기 존재하는 면역의 부재는 아데노바이러스 캡시드 단백질 헥손의 신규한 초가변 영역에 기인한다. 신규 아데노바이러스 균주는 또한 증식 능력이 향상되었다. 본 발명은 이들 균주를 기반으로 한 재조합 바이러스, 바이러스-유사 입자 및 벡터뿐만 아니라, 이들 신규 아데노바이러스 균주의 뉴클레오타이드 및 아미노산 서열을 제공한다. 약제학적 조성물 및 질병의 치료 또는 예방에서의 의학적 용도, 및 신규 서열, 재조합 바이러스, 바이러스-유사 입자 및 벡터를 사용하는 아데노바이러스 또는 바이러스-유사 입자의 제조 방법이 추가로 제공된다.

아데노바이러스 (Ad)는 무 외피의 정이십면체형 캡시드 구조를 갖고, 양서류, 조류 및 포유류에서 발견되는 이중 가닥 DNA 바이러스의 대규모 패밀리를 포함한다 (문헌[Straus, Adenovirus infections in humans; The Adenoviruses, 451-498, 1984; Hierholzer et al., J. Infect.Dis.,158: 804-813,1988; Schnurr and Dondero, Intervirology., 36: 79-83,1993; Jong et al., J. Clin. Microbiol., 37: 3940-3945: 1999]). 레트로바이러스와는 달리, 아데노바이러스는 숙주 세포의 게놈으로 혼입되지 않으면서 분열 및 비 분열 세포 둘 모두를 포함하여 다수의 포유류 종의 수많은 세포 유형을 형질도입시킬 수 있다.

일반적으로 말하면, 아데노바이러스 DNA는 통상적으로 매우 안정하고, 형질전환 또는 종양 발생이 일어나지 않는 한, 에피솜 (예를 들어, 염색체외)으로 유지된다. 또한, 아데노바이러스 벡터는 임상 등급 조성물의 약제학적 규모의 생성에 용이한 적용 가능하고, 적절하게 규정되어 있는 생성 시스템에서 높은 수율로 증식될 수 있다. 이러한 특징 및 그의 적절하게 특성화된 분자 유전학은 재조합 아데노바이러스 벡터를 백신 전달체로서 사용하기에 적합한 후보가 되도록 한다. 재조합 아데노바이러스 벡터의 생성은 비기능성으로 설계되거나, 결실된 아데노바이러스 유전자 산물의 기능을 보완할 수 있는 패키징 (packaging) 세포주의 사용에 의존할 수 있다.

현재, 적절하게 특성화된 2개의 인간 서브 그룹 C 아데노바이러스 혈청형 (즉, hAd2 및 hAd5)은 유전자 요법에 사용되는 대부분의 아데노바이러스 벡터에 대한 바이러스 백본의 공급원으로서 광범위하게 사용된다. 복제-결함 인간 아데노바이러스 벡터는 또한 다양한 감염원으로부터 유래된 다양한 면역원의 전달을 위한 백신 전달체로서 시험되어 왔다. 실험 동물 (예를 들어, 설치류, 개 및 비인간 영장류)에서 수행된 연구에 의하면, 다른 항원뿐만 아니라, 면역원을 인코딩하는 전이유전자를 보유하는 재조합 복제-결함 인간 아데노바이러스 벡터가 전이유전자 산물에 대한 체액성 및 세포-매개 면역 반응을 모두 유발하는 것으로 나타난다. 일반적으로 말하면, 연구자들은 면역 반응을 유발할 것으로 예측되는 고 투여량의 재조합 아데노바이러스 벡터를 이용하는 면역화 프로토콜을 사용하거나; 상이한 혈청형으로부터 유래되지만 부스팅 면역화와 동일한 전이유전자 산물을 보유하는 아데노바이러스 벡터의 순차적 투여를 사용하는 면역화 프로토콜을 사용함으로써, 비인간 실험 시스템에서 백신 전달체로서 인간 아데노바이러스 벡터를 사용한 성공 예를 보고한 바 있다 (문헌[Mastrangeli, et al., Human Gene Therapy, 7: 79-87 (1996)]).

C 아데노바이러스종 (예를 들어, Ad5, Ad6 및 ChAd63)로부터 유래된 벡터는 가장 면역원성이 높다 (문헌[Colloca et al., Sci. Transl. Med. 4 (115), 2012]). 특히, 인간 아데노바이러스 5형 (Ad5)을 기반으로 한 바이러스 벡터가 유전자 요법 및 백신 적용을 위해 개발되었다. Ad5 기반 벡터는 동물 모델에서 매우 효율적이지만, 인간에서 Ad5 야생형 바이러스에 대한 기 존재하는 면역의 존재는 임상 실험에서 유전자 형질도입 효율을 감소시키는 것으로 나타났다 (문헌[Moore JP et al. Science. 2008 May 9; 320 (5877):753-5]). 따라서, 일반 인구에서의 면역은 Ad5를 기반으로 한 Ad 벡터 백신의 광범위한 적용을 제한한다. 한편, 희소 인간 아데노바이러스는 Ad5보다 면역원성이 더 적다 (문헌[Colloca et al., Sci. Transl. Med. 4 (115), 2012]). 비인간 아데노바이러스를 기반으로 한 벡터는 일반 인구 집단에서 기 존재하는 면역이 부재한다 (문헌[Farina et al., J. Virol. 75 (23), 11603-11613, 2001]).

따라서, 인간에서 면역원성이 높고, 기 존재하는 면역이 낮거나 부재하는 아데노바이러스 벡터가 필요한 상황이다. 바람직하게는, 이들 아데노바이러스 벡터는 복제 측면에서 높은 증식성을 갖는다.

[발명의 요약]

제1 양상에서, 본 발명은 다음을 포함하는 아데노바이러스 헥손 단백질을 인코딩하는 단리된 폴리뉴클레오타이드를 제공한다:

A) (i) 서열번호 11에 따른 아미노산 서열 또는 서열번호 11에 적어도 85% 서열 동일성을 갖고, 27 번이 A가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제1 초가변 영역 HVR1,

(ii) 서열번호 12에 따른 아미노산 서열 또는 서열번호 12에 적어도 85% 서열 동일성을 갖고, 1 번이 L이 아니고 바람직하게는 I인 그의 변이체를 포함하는 제2 가변 영역 HVR2,

(iii) 서열번호 13에 따른 아미노산 서열 또는 서열번호 13에 적어도 85% 서열 동일성을 갖고, 7 번이 V가 아니고 바람직하게는 A인 그의 변이체를 포함하는 제3 가변 영역 HVR3,

(iv) 서열번호 14에 따른 아미노산 서열 또는 서열번호 14에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제4 초가변 영역 HVR4,

(v) 서열번호 15에 따른 아미노산 서열 또는 서열번호 15에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제5 초가변 영역 HVR5,

(vi) 서열번호 16에 따른 아미노산 서열 또는 서열번호 16에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제6 초가변 영역 HVR6, 및

(vii) 서열번호 17에 따른 아미노산 서열 또는 서열번호 17에 적어도 85% 서열 동일성을 갖고, 1 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제7 초가변 영역 HVR7; 또는

B) (i) 서열번호 18에 따른 아미노산 서열 또는 서열번호 18에 적어도 85% 서열 동일성을 갖고, 8 번이 V가 아니고 바람직하게는 E이고/이거나, 12 번이 D가 아니고 바람직하게는 E이고/이거나, 13 번이 E가 아니고 바람직하게는 D이고/이거나, 14 번이 L이 아니고 바람직하게는 V인 그의 변이체를 포함하는 제1 초가변 영역 HVR1,

(ii) 서열번호 19에 따른 아미노산 서열 또는 서열번호 19에 적어도 85% 서열 동일성을 갖고, 10 번이 D가 아니고 바람직하게는 E인 그의 변이체를 포함하는 제2 가변 영역 HVR2,

(iii) 서열번호 20에 따른 아미노산 서열 또는 서열번호 20에 적어도 85% 서열 동일성을 갖고, 6 번이 T가 아니고 바람직하게는 A인 그의 변이체를 포함하는 제3 가변 영역 HVR3,

(iv) 서열번호 21에 따른 아미노산 서열 또는 서열번호 21에 적어도 85% 서열 동일성을 갖고, 9 번이 L이 아니고 바람직하게는 M인 그의 변이체를 포함하는 제4 초가변 영역 HVR4,

(v) 서열번호 22에 따른 아미노산 서열 또는 서열번호 22에 적어도 85% 서열 동일성을 갖고, 3 번이 T가 아니고 바람직하게는 S인 그의 변이체를 포함하는 제5 초가변 영역 HVR5,

(vi) 서열번호 23에 따른 아미노산 서열 또는 서열번호 23에 적어도 85% 서열 동일성을 갖고, 9 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제6 초가변 영역 HVR6 및

(vii) 서열번호 24에 따른 아미노산 서열 또는 서열번호 24에 적어도 85% 서열 동일성을 갖고, 8 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제7 초가변 영역 HVR7; 또는

C) (i) 서열번호 25에 따른 아미노산 서열 또는 서열번호 25에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제1 초가변 영역 HVR1,

(ii) 서열번호 26에 따른 아미노산 서열 또는 서열번호 26에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제2 가변 영역 HVR2,

(iii) 서열번호 27에 따른 아미노산 서열 또는 서열번호 27에 적어도 85% 서열 동일성을 갖고, 7 번이 V가 아니고 바람직하게는 A인 그의 변이체를 포함하는 제3 가변 영역 HVR3,

(iv) 서열번호 28에 따른 아미노산 서열 또는 서열번호 28에 적어도 85% 서열 동일성을 갖고, 10 번이 E가 아니고 바람직하게는 Q인 그의 변이체를 포함하는 제4 초가변 영역 HVR4,

(v) 서열번호 29에 따른 아미노산 서열 또는 서열번호 29에 적어도 85% 서열 동일성을 갖고, 3 번이 T가 아니고 바람직하게는 S인 그의 변이체를 포함하는 제5 초가변 영역 HVR5,

(vi) 서열번호 30에 따른 아미노산 서열 또는 서열번호 30에 적어도 85% 서열 동일성을 갖고, 9 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제6 초가변 영역 HVR6 및

(vii) 서열번호 31에 따른 아미노산 서열 또는 서열번호 31에 적어도 85% 서열 동일성을 갖고, 8 번이 I가 아니고 바람직하게는 V이고/이거나, 11 번이 T가 아니고 바람직하게는 S인 그의 변이체를 포함하는 제7 초가변 영역 HVR7; 또는

D) (i) 서열번호 32에 따른 아미노산 서열 또는 서열번호 32에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제1 초가변 영역 HVR1,

(ii) 서열번호 33에 따른 아미노산 서열 또는 서열번호 33에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제2 가변 영역 HVR2,

(iii) 서열번호34에 따른 아미노산 서열 또는 서열번호 34에 적어도 85% 서열 동일성을 갖고, 6 번이 T가 아니고 바람직하게는 A인 그의 변이체를 포함하는 제3 가변 영역 HVR3,

(iv) 서열번호 35에 따른 아미노산 서열 또는 서열번호 35에 적어도 85% 서열 동일성을 갖고, 6 번이 Q가 아니고 바람직하게는 K이고/이거나, 10 번이 E가 아니고 바람직하게는 Q인 그의 변이체를 포함하는 제4 초가변 영역 HVR4,

(v) 서열번호 36에 따른 아미노산 서열 또는 서열번호 36에 적어도 85% 서열 동일성을 갖고, 3 번이 T가 아니고 바람직하게는 S인 그의 변이체를 포함하는 제5 초가변 영역 HVR5,

(vi) 서열번호 37에 따른 아미노산 서열 또는 서열번호 37에 적어도 85% 서열 동일성을 갖고, 1 번이 K가 아니고 바람직하게는 T이고/이거나, 9 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제6 초가변 영역 HVR6 및

(vii) 서열번호 38에 따른 아미노산 서열 또는 서열번호 38에 적어도 85% 서열 동일성을 갖고, 8 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제7 초가변 영역 HVR7; 또는

E) (i) 서열번호 39에 따른 아미노산 서열 또는 서열번호 39에 적어도 85% 서열 동일성을 갖고, 27 번이 A가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제1 초가변 영역 HVR1,

(ii) 서열번호 40에 따른 아미노산 서열 또는 서열번호 40에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제2 가변 영역 HVR2,

(iii) 서열번호 41에 따른 아미노산 서열 또는 서열번호 41에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제3 가변 영역 HVR3,

(iv) 서열번호 42에 따른 아미노산 서열 또는 서열번호 42에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제4 초가변 영역 HVR4,

(v) 서열번호 43에 따른 아미노산 서열 또는 서열번호 43에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제5 초가변 영역 HVR5,

(vi) 서열번호 44에 따른 아미노산 서열 또는 서열번호 44에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 제6 초가변 영역 HVR6 및

(vii) 서열번호 45에 따른 아미노산 서열 또는 서열번호 45에 적어도 85% 서열 동일성을 갖고, 1 번이 I가 아니고 바람직하게는 V인 그의 변이체를 포함하는 제7 초가변 영역 HVR7.

제2 양상에서, 본 발명은 제1 양상의 폴리뉴클레오타이드를 포함하는 아데노바이러스, 바람직하게는 복제-불능 아데노바이러스를 인코딩하는 단리된 폴리뉴클레오타이드를 제공한다.

제양상에서, 본 발명은 제1 양상의 단리된 폴리뉴클레오타이드에 의해 인코딩되는 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드를 제공한다.

제4 양상에서, 본 발명은 제1 양상의 단리된 폴리뉴클레오타이드에 의해 인코딩되는 아데노바이러스, 또는 제1 양상에 따른 단리된 폴리뉴클레오타이드 및/또는 제3 양상에 따른 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드를 포함하는 단리된 아데노바이러스, 바람직하게는 복제-불능 아데노바이러스를 제공한다.

제5 양상에서, 본 발명은 제1 양상의 단리된 폴리뉴클레오타이드에 의해 인코딩되는 바이러스-유사 입자를 제공한다.

제6 양상에서, 본 발명은 제1 양상의 단리된 폴리뉴클레오타이드를 포함하는 벡터를 제공한다.

제7 양상에서, 본 발명은 (i) 애주번트, (ii) 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및 선택적으로 (iii) 약제학적으로 허용 가능한 부형제를 포함하는 조성물을 제공한다.

제8 양상에서, 본 발명은 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터를 포함하는 세포를 제공한다.

제9 양상에서, 본 발명은 질병의 치료 또는 예방에 사용하기 위한 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자, 또는 제6 양상의 벡터 및/또는 제7 양상의 조성물을 제공한다.

제10 양상에서, 본 발명은 (i) 세포에서 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드를 발현시켜, 아데노바이러스 또는 아데노바이러스-유사 입자가 세포내에서 조립되는 단계; 및

(ii) 세포 또는 세포 주위의 배지로부터 아데노바이러스 또는 아데노바이러스-유사 입자를 단리하는 단계를 포함하는, 아데노바이러스 또는 아데노바이러스-유사 입자를 생성하는 시험관내(in vitro) 방법에 관한 것이다.

본 발명을 하기에 상세하게 기재하기 전에, 본 발명이 본 명세서에 기재된 특정 방법론, 프로토콜 및 시약에 제한되지 않는 것으로 이해되어야 한다. 또한, 본 명세서에서 사용된 용어는 특정 실시형태를 설명하기 위한 것이고, 본 발명의 범위를 제한하려는 것이 아니며, 본 발명의 범위는 첨부된 청구범위에 의해서만 제한됨을 이해해야 한다. 달리 정의되지 않는 한, 본 명세서에 사용된 모든 기술 및 과학 용어는 당업자가 일반적으로 이해하는 것과 동일한 의미를 갖는다.

바람직하게는, 본 명세서에 사용되는 바와 같이, 용어는 문헌["A multilingual glossary of biotechnological terms: (IUPAC Recommendations)", Leuenberger, H.G.W, Nagel, B. and Klbl, H. eds. (1995), Helvetica Chimica Acta, CH-4010 Basel, Switzerland)]에 기재된 바 및 Axel Kleemann 및 Jurgen Engel의 문헌["Pharmaceutical Substances: Syntheses, Patents, Applications"]; Susan Budavari 등에 의해 편집된 문헌[Thieme Medical Publishing, 1999; the "Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals"], 2001년 미국 메릴랜드주 록빌 소재의 United States Pharmcopeial Convention, Inc.에 의해 발간된 문헌[CRC Press, 1996, and the United States Pharmacopeia-25/National Formulary-20]에 기재된 바와 같이 규정된다.

본 명세서 및 하기의 청구범위 전체에서, 문맥상 달리 요구하지 않는 한, 단어 "~들을 포함하다" 및 "~를 포함하다" 및 "~를 포함하는"과 같은 변용예는 언급된 특징, 정수 또는 단계 또는 특징, 정수 또는 단계의 그룹을 포함하지만, 임의의 다른 특징, 정수 또는 단계 또는 정수 또는 단계의 그룹을 배제하지 않는 것을 의미하는 것으로 이해될 것이다. 하기 구절에서, 본 발명의 상이한 양상이 더욱 상세하게 규정된다. 이렇게 규정된 각각의 양상은 달리 명확하게 지시되지 않는 한 임의의 다른 양상 또는 양상들과 조합될 수 있다. 특히, 바람직하거나 유리한 것으로 언급된 임의의 특징은 바람직하거나 유리한 것으로 언급된 임의의 다른 특징 또는 특징들과 조합될 수 있다.

본 명세서의 내용 전체에 걸쳐 다수의 문헌이 인용되어 있다. 본 명세서에 인용된 각각의 문헌 (모든 특허, 특허 출원, 과학 간행물, 제조업체의 설명서, 지침 등 포함)은 상기 또는 하기에 기재되었는지에 상관없이 그 전문이 본 명세서에 참조로 포함된다. 본 명세서 내의 문헌은 모두 선행 발명의 관점에서 그 개시내용이 본 발명을 선행한다는 인정으로 해석되어서는 안된다.

도면의 간단한 설명

도 1: BAC GAd-GAG A/L/S 셔틀 벡터 (shuttle vector)의 개략도.

도 2: E1-및 E3-결실된 GAdNou19 GAG (DE1E3) BAC 플라스미드의 개략도.

도 3: E1-및 E3-결실된 GAdNou20 GAG (DE1E3) BAC 플라스미드의 개략도.

도 4: 동일한 발현 카세트를 보유하는 벤치마크 Ad5 벡터와 비교한 Hek293에서의 GADNOU19 및 GADNOU20의 증식성.

도 5: GAG 항원을 인코딩하는 GADNOU19 및 GADNOU20 벡터의 면역원성. GADNOU19 GAG (DE1DE3) 및 GADNOU20 GAG (DE1DE3) 벡터의 면역 역가를 IFN-γ ELISpot에 의해 결정하였다. 각 벡터의 3x10^7 및 3x10^6 vp로 면역화한지 3주 후에 T 세포 반응을 측정한다. CD8+ 에피토프를 인코딩하는 면역 우성 gag 펩타이드에 의한 자극에 반응하여 수백만개의 비장 세포당 IFNγ를 생성하는 T 세포의 수가 도시되어 있다.

뉴클레오타이드 및 아미노산 서열

하기 표 1은 본 명세서에 언급된 서열에 대한 요약을 제공한다 (GADNOU+ 수: 단리된 아데노바이러스 균주; *: 아미노산 서열을 인코딩하는 GADNOU 게놈의 상응하는 뉴클레오타이드 서열, 서열 상응성은 나열된 순서에 따르고, 예를 들어 서열번호 11의 경우, HVR1 GADNOU 20은 서열번호 1의 x-x에 상응하고, HVR1 GADNOU 21은 서열번호 2의 x-x에 상응하고, HVR1 GADNOU 25는 서열번호 3의 x-x에 상응함). GADNOU는 본 발명자들의 균주명이다. 하기에 제공된 헥손, 펜톤, 섬유에 대한 게놈 좌표의 범위 (GADNOU 게놈에서 서열번호 46 내지 54)는 최종 종결 코돈을 포함하지 않으며, 이는 좌표를 사용하여 헥손, 펜톤 또는 섬유를 인코딩하는 폴리뉴클레오타이드를 언급할 때 본 개시내용에 선택적으로 포함/추가된다.

하기 표 2a 및 표 2b는 GADNOU 게놈에서 CDS, RNA 및 ITR의 게놈 범위/좌표를 제공한다. 이는 표에 열거되고 각각의 실시형태에 바람직하게 포함된 본 명세서의 게놈 요소에 대한 임의의 인용에 적용된다.

[표 2a]

[표 2b]

본 발명의 양상 및 그의 특정 실시형태

본 발명은 상기 발명의 요약에서 제시된 바와 같은 수 개의 양상에 관한 것이다. 이들 양상은 하기에 기재되는 대안적인 실시형태 및 바람직한 실시형태를 포함한다.

제1 양상에서, 본 발명은 상기의 발명의 내용에 규정된 바와 같은 아데노바이러스 헥손 단백질을 인코딩하는 단리된 폴리뉴클레오타이드를 제공한다.

바람직한 실시형태에서, HVR 변이체는 각각의 서열번호에 적어도 90% 이상, 바람직하게는 적어도 95% 서열 동일성을 갖는다. 서열 동일성 백분율 수준에 의한 규정에 대안적으로, HVR은 각각의 서열번호 내에 특정 수의 아미노산 돌연변이를 갖는 것으로 규정될 수 있다. 그 후 돌연변이 수는 다음과 같다: 적어도 85% 서열 동일성 대신, 임의의 HVR1에 최대 4개의 돌연변이, 임의의 HVR2에 최대 2개의 돌연변이, 임의의 HVR3에 최대 1개의 돌연변이, 임의의 HVR4에 최대 1개의 돌연변이, 임의의 HVR5에 최대 2개의 돌연변이, 임의의 HVR6에 최대 1개의 돌연변이 및 임의의 HVR7에 최대 3 돌연변이; 적어도 90% 서열 동일성 대신, 임의의 HVR1에 최대 2개의 돌연변이, 임의의 HVR2에 최대 1개의 돌연변이, 임의의 HVR3에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이, 임의의 HVR4에 최대 1개의 돌연변이, 임의의 HVR5에 최대 1개의 돌연변이, 임의의 HVR6에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이 및 임의의 HVR7에 최대 2개의 돌연변이; 적어도 95% 서열 동일성 대신, 임의의 HVR1에 최대 1개의 돌연변이, 임의의 HVR2에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이, 임의의 HVR3에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이, 임의의 HVR4에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이, 임의의 HVR5에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이, 임의의 HVR6에 최대 1개의 돌연변이 및 바람직하게는 0개의 돌연변이 및 임의의 HVR7에 최대 1개의 돌연변이.

당 업계, 예를 들어 문헌[Bradley et al. (J Virol., 2012 Jan;86(2):1267-72)]에 공지된 바와 같이, 아데노바이러스 중화 항체는 헥손 초가변 영역을 표적화하고, 아데노바이러스의 HVR 영역을 혈청 내에 다량 존재하는 것으로 대체함으로써, 아데노바이러스가 면역 숙주의 면역 시스템을 우회할 수 있다. 따라서, 상기 HVR은 하기에 규정된 각각의 헥손 단백질을 사용할 수 있지만, 이는 헥손 단백질 및 또한 하기 펜톤 및 섬유 단백질과는 별개의, 즉 다른 헥손, 펜톤 및/또는 섬유 단백질을 갖는 상이한 아데노바이러스의 헥손 HVR을 대체함으로써 유용성을 갖는다.

바람직한 실시형태에서, 헥손 단백질은 다음을 포함한다:

A) 서열번호 46에 따른 아미노산 서열 또는 서열번호 46에 적어도 85% 서열 동일성을 갖는 그의 변이체,

B) 서열번호 47에 따른 아미노산 서열 또는 서열번호 47에 적어도 85% 서열 동일성을 갖는 그의 변이체,

C) 서열번호 48에 따른 아미노산 서열 또는 서열번호 48에 적어도 85% 서열 동일성을 갖는 그의 변이체,

D) 서열번호 49에 따른 아미노산 서열 또는 서열번호 49에 적어도 85% 서열 동일성을 갖는 그의 변이체, 및/또는

E) 서열번호 50에 따른 아미노산 서열 또는 서열번호 50에 적어도 85% 서열 동일성을 갖는 그의 변이체.

바람직한 실시형태에서, 헥손 변이체는 각각의 서열번호에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98% 또는 99% 서열 동일성을 갖는다. 서열 동일성 백분율 수준에 의한 규정에 대안적으로, 헥손 변이체는 각각의 서열번호내에 특정 수의 아미노산 돌연변이를 갖는 것으로 규정될 수 있다. 그 후 돌연변이 수는 다음과 같다: 적어도 85% 서열 동일성 대신, 임의의 헥손에 최대 143개의 돌연변이; 적어도 90% 서열 동일성 대신, 임의의 헥손에 최대 95개의 돌연변이; 적어도 95% 서열 동일성 대신, 임의의 헥손에 최대 47개의 돌연변이; 적어도 96% 서열 동일성 대신, 임의의 헥손에 최대 38개의 돌연변이; 적어도 97% 서열 동일성 대신, 임의의 헥손에 최대 28개의 돌연변이; 적어도 98% 서열 동일성 대신, 임의의 헥손에 최대 19개의 돌연변이; 적어도 99% 서열 동일성 대신, 임의의 헥손에 최대 9개의 돌연변이. 헥손 변이체이 상기에 각각의 HVR에 대해 규정된 것보다 더 적은 서열 동일성을 갖거나, 그의 HVR에 더 많은 돌연변이를 갖지 않음이 이해되어야 한다.

일 실시형태에서, 제1 양상의 단리된 폴리뉴클레오타이드는 서열번호 51 또는 52에 따른 아미노산 서열 또는 서열번호 51 또는 52에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 아데노바이러스 펜톤 단백질을 추가로 인코딩한다. 바람직한 실시형태에서, 펜톤 변이체는 각각의 서열번호에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98% 또는 99% 서열 동일성을 갖는다. 서열 동일성 백분율 수준에 의한 규정에 대안적으로, 펜톤 변이체는 각각의 서열번호 내에 특정 수의 아미노산 돌연변이를 갖는 것으로 규정될 수 있다. 그 후 돌연변이 수는 다음과 같다: 적어도 85% 서열 동일성 대신, 임의의 펜톤에 최대 97개의 돌연변이; 적어도 90% 서열 동일성 대신, 임의의 펜톤에 최대 65개의 돌연변이; 적어도 95% 서열 동일성 대신, 임의의 펜톤에 최대 32개의 돌연변이; 적어도 96% 서열 동일성 대신, 임의의 펜톤에 최대 26개의 돌연변이; 적어도 97% 서열 동일성 대신, 임의의 펜톤에 최대 19개의 돌연변이; 적어도 98% 서열 동일성 대신, 임의의 펜톤에 최대 13개의 돌연변이; 적어도 99% 서열 동일성 대신, 임의의 펜톤에 최대 6개의 돌연변이.

바람직하게는, 서열번호 51 및 52의 펜톤 변이체는 각각 289 번이 D가 아니고, 바람직하게는 G이고, 341 번이 D가 아니고, 바람직하게는 N이다. 더욱 바람직하게는, 서열번호 52의 변이체는 또한 442 번이 A가 아니고, 더욱 바람직하게는 T이다.

또 다른 실시형태에서, 제1 양상의 단리된 폴리뉴클레오타이드 (즉, 헥손 및 가능하게는 펜톤 단백질 다음에 위치함)는 서열번호 53 또는 54에 따른 아미노산 서열 또는 서열번호 53 또는 54에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 아데노바이러스 섬유 단백질을 추가로 인코딩한다. 바람직한 실시형태에서, 섬유 변이체는 각각의 서열번호에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98% 또는 99% 서열 동일성을 갖는다. 서열 동일성 백분율 수준에 의한 규정에 대안적으로, 섬유 변이체는 각각의 서열번호 내에 특정 수의 아미노산 돌연변이를 갖는 것으로 규정될 수 있다. 그 후 돌연변이 수는 다음과 같다: 적어도 85% 서열 동일성 대신, 임의의 섬유에 최대 89개의 돌연변이; 적어도 90% 서열 동일성 대신, 임의의 섬유에 최대 59개의 돌연변이; 적어도 95% 서열 동일성 대신, 임의의 섬유에 최대 29개의 돌연변이; 적어도 96% 서열 동일성 대신, 임의의 섬유에 최대 23개의 돌연변이; 적어도 97% 서열 동일성 대신, 임의의 섬유에 최대 17개의 돌연변이; 적어도 98% 서열 동일성 대신, 임의의 섬유에 최대 11개의 돌연변이; 적어도 99% 서열 동일성 대신, 임의의 섬유에 최대 5개의 돌연변이.

바람직하게는, 서열번호 53의 섬유 변이체는 181 번이 A가 아니고 바람직하게는 P이고/이거나, 474 번이 V가 아니고 바람직하게는 I이고/이거나, 4 번 및 5 번 사이에 S, 바람직하게는 아미노산이 삽입되어 있지 않다. 바람직하게는, 서열번호 54의 섬유 변이체는 90 번이 T가 아니고 바람직하게는 I이고/이거나, 7 번이 S이다 (바람직하게는 4 번 내지 7 번의 각각이 S임).

또 다른 실시형태에서, 제1 양상의 단리된 폴리뉴클레오타이드 (즉, 헥손 및 가능하게는 펜톤 및/또는 섬유 단백질 다음에 위치함)는 서열번호 57에 따른 뉴클레오타이드 서열 또는 서열번호 57에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 VA RNA II 비코딩 RNA를 추가로 인코딩한다. 대안적 또는 부가적으로, 이는 각각 서열번호 55 또는 56에 따른 뉴클레오타이드 서열 또는 서열번호 55 또는 56에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 VA RNA I 비코딩 RNA를 인코딩할 수 있다. 바람직한 실시형태에서, VA RNA 변이체는 각각의 서열번호에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98% 또는 99% 서열 동일성을 갖는다. 서열 동일성 백분율 수준에 의한 규정에 대안적으로, VA RNA 변이체는 각각의 서열번호 내에 특정 수의 뉴클레오타이드 돌연변이를 갖는 것으로 규정될 수 있다. 그 후 돌연변이 수는 다음과 같다: 적어도 85% 서열 동일성 대신, VA RNA I에 최대 25개의 돌연변이 및 VA RNA II에 최대 26개의 돌연변이; 적어도 90% 서열 동일성 대신, VA RNA I에 최대 16개의 돌연변이 및 VA RNA II에 최대 17개의 돌연변이; 적어도 95% 서열 동일성 대신, 임의의 VA RNA에 최대 8개의 돌연변이; 적어도 96% 서열 동일성 대신, 임의의 VA RNA에 최대 6개의 돌연변이; 적어도 97% 서열 동일성 대신, 임의의 VA RNA에 최대 5개의 돌연변이; 적어도 98% 서열 동일성 대신, 임의의 VA RNA에 최대 3개의 돌연변이; 적어도 99% 서열 동일성 대신, 임의의 VA RNA에 최대 1개의 돌연변이.

바람직하게는, 서열번호 57의 VA RNA II 변이체는 (a) 79 번이 C가 아니고/아니거나, 80 번이 A가 아니고, 바람직하게는 79 번은 T이고/이거나, 80 번이 G이고, (b) 81 번이 A가 아니고, 바람직하게는 81 번은 G이다. 서열번호 55의 VA RNA I 변이체는 80 번이 G가 아니고, 바람직하게는 80 번은 A이다.

본 발명에 따른 VA RNA는 실시예 5에 제시된 바와 같이, 아데노바이러스 또는 아데노바이러스-유사 입자 생성을 향상시킨다.

제1 양상의 폴리뉴클레오타이드는 아데노바이러스 게놈에서 헥손, 펜톤 및/또는 섬유 유전자에 인접한, 다른 아데노바이러스 유전자 및 뉴클레오타이드 절편을 추가로 포함하는 것이 바람직하고, 참조번호로서 서열번호 1 내지 10을 사용한다. 상기 폴리뉴클레오타이드는 또한 아데노바이러스 입자 내로의 폴리뉴클레오타이드 패키징에 필요한 서열을 포함하는 것이 특히 바람직하다.

일반적으로, 제1 양상의 단리된 폴리뉴클레오타이드는 다음 중 적어도 하나를 포함하는 것이 바람직하다:

(a) 아데노바이러스 5' 말단, 바람직하게는 아데노바이러스 5' 역위 말단 반복;

(b) 아데노바이러스 Ela 영역 또는 13S, 12S 및 9S 영역 중의 것으로부터 선택되는 그의 단편;

(c) 아데노바이러스 Elb 영역 또는 소형 T, 대형 T 및 IX 영역으로 이루어진 군 중의 것으로부터 선택되는 그의 단편;

(d) 아데노바이러스 VA RNA 영역; 또는 VA RNA I 및 VA RNA II 영역으로 이루어진 군 중의 것으로부터 선택되는 그의 단편;

(e) 아데노바이러스 E2b 영역; 또는 소형 pTP, 중합효소 및 IVa2 영역으로 이루어진 군 중의 것으로부터 선택되는 그의 단편;

(f) 아데노바이러스 L1 영역 또는 그의 단편 (상기 단편은 28.1 kD 단백질, 중합효소, 아그노단백질, 52/55 kDa 단백질 및 IIIa 단백질로 이루어진 군으로부터 선택되는 아데노바이러스 단백질을 인코딩함);

(g) 아데노바이러스 L2 영역 또는 그의 단편 (상기 단편은 상기에 규정된 바와 같은 펜톤 단백질, VII, V 및 X 단백질로 이루어진 군으로부터 선택되는 아데노바이러스 단백질을 인코딩함);

(h) 아데노바이러스 L3 영역 또는 그의 단편 (상기 단편은 VI 단백질, 상기에 규정된 바와 같은 헥손 단백질 및 엔도프로테아제로 이루어진 군으로부터 선택되는 아데노바이러스 단백질을 인코딩함);

(i) 아데노바이러스 E2a 영역 또는 그의 단편 (상기 단편은 DBP 단백질로 이루어진 아데노바이러스 단백질을 인코딩함);

(j) 아데노바이러스 L4 영역 또는 그의 단편 (상기 단편은 100 kD 단백질, 22 kD 상동체, 33 kD 상동체 및 단백질 VIII로 이루어진 군으로부터 선택되는 아데노바이러스 단백질을 인코딩함);

(k) 아데노바이러스 E3 영역 또는 E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8 및 E3 ORF9로 이루어진 군으로부터 선택되는 그의 단편;

(l) 아데노바이러스 L5 영역 또는 그의 단편 (상기 단편은 상기에 규정된 바와 같은 섬유 단백질을 인코딩함);

(m) 아데노바이러스 E4 영역 또는 E4 ORF6/7, E4 ORF6, E4 ORF5, E4 ORF4, E4 ORF3, E4 ORF2 및 E4 ORF1로 이루어진 군으로부터 선택되는 그의 단편; 및/또는

(n) 아데노바이러스 3' 말단, 바람직하게는 아데노바이러스 3' 역위 말단 반복.

키메라 아데노바이러스를 형성하기 위한 이러한 요소는 표 1에 따른 (즉, 동일한 GADNOU로 부터) 제1 양상의 폴리뉴클레오타이드의 HVR 및/또는 헥손과 동일한 아데노바이러스 또는 상이한 아데노바이러스, 특히 상이한 종 중 하나, 예를 들어 인간 아데노바이러스 유래의 것일 수 있다.

상기 언급된 폴리뉴클레오타이드의 일부 실시형태에서, 폴리뉴클레오타이드는 상기 요약된 바와 같은 ((a) 내지 (m), 예를 들어 영역 E3 및/또는 E4에서와 같은) 하나 이상의 게놈 영역을 포함하지 않고/않거나, 적어도 하나의 유전자가 비기능성이 되도록 하는 결실 및/또는 돌연변이를 포함하는 아데노바이러스 유전자를 포함하는 것이 바람직할 수 있다. 이러한 바람직한 실시형태에서, 적합한 아데노바이러스 영역은 상기 언급된 영역 (들)/유전자 (들)를 포함하지 않거나, 선택된 영역 (들)/유전자 (들)가 비기능성이 되도록 변형된다. 이를 비기능성이 되도록 하는 한 가지 가능성은 하나 이상의 인위적 종결 코돈 (예를 들어, TAA)을 이들 유전자의 오픈 리딩 프레임에 도입하는 것이다. 바이러스가 복제 결함이 있도록 하는 방법은 당 업계에 널리 공지되어 있다 (예를 들어, 문헌[Brody et al., 1994 Ann NY Acad Sci., 716: 90-101] 참조). 결실은 바람직하게는 본 명세서에 기재된 바와 같은 미니유전자 카세트와 같은 발현 카세트 내에 전이유전자를 삽입하기 위한 공간을 생성시킬 수 있다. 또한, 결실을 사용하여, 당 업계에 널리 공지된 바와 같은 패키징 세포주 또는 보조 바이러스를 사용하지 않고 복제할 수 없는 아데노바이러스 벡터를 생성할 수 있다. 따라서, 명시된 유전자/영역 결실 또는 기능 상실 돌연변이 중 하나 이상을 포함하는 상기 요약된 폴리뉴클레오타이드를 포함하는 최종 재조합 아데노바이러스는 예를 들어유전자 요법 또는 예방접종을 위해 더욱 안전한 재조합 아데노바이러스를 제공할 수 있다.

폴리뉴클레오타이드는 본 명세서에 요약된 바와 같은 (예를 들어 영역 E3 및/또는 E4와 같은) 적어도 하나의 게놈 영역/유전자, 구체적으로 E1A, E1B, E2A, E2B, E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, E3 ORF9, E4 ORF6/7, E4 ORF6, E4 ORF5, E4 ORF4, E4 ORF3, E4 ORF2 및/또는 E4 ORF1, 바람직하게는 E1A, E1B, E2A, E2B, E3 및/또는 E4를 포함하지 않을 수 있고/거나, 적어도 하나의 유전자가 비기능성이 되도록 하는 결실 및/또는 돌연변이를 포함하는 아데노바이러스 유전자를 포함하고, 완전한 Ela 및/또는 Elb 영역을 보유하는 것이 바람직하다. 이러한 완전한 El 영역은 아데노바이러스 게놈의 그의 원 위치에 위치할 수 있거나, 본래의 아데노바이러스 게놈 (예를 들어, E3 영역)의 결실 부위에 배치될 수 있다.

바람직한 실시형태에서, 제1 양상의 단리된 폴리뉴클레오타이드는 다음 아데노바이러스 단백질: 단백질 VI, 단백질 VIII, 단백질 IX, 단백질 IIIa 및 단백질 IVa2 중 하나 이상, 바람직하게는 그 모두를 추가로 인코딩한다.

아데노바이러스의 당업자는 상기 명시된 아데노바이러스 단백질을 인코딩하는 오픈 리딩 프레임을 결정하는 방법을 잘 인식하고 있다. 당업자는 또한 아데노바이러스 게놈의 구조를 알고 있으며, 과도한 부담없이, 본 명세서에 요약된 개별 아데노바이러스 영역 및 ORF를 임의의 아데노바이러스 게놈에 맵핑 (maping)할 수 있다.

또 다른 실시형태에서, 제1 양상의 단리된 폴리뉴클레오타이드는 하나 이상의 이종성 단백질 또는 그의 단편을 추가로 인코딩한다. 하나 이상의 이종성 단백질 또는 그의 단편은 바람직하게는 비-아데노바이러스 단백질 또는 그의 단편이다. 바람직한 실시형태에서, 하나 이상의 비-아데노바이러스 단백질 또는 그의 단편은 하나 이상의 항원성 단백질 또는 그의 단편이다. 바람직하게는, 하나 이상의 이종성 단백질 또는 그의 단편은 하나 이상의 발현 카세트의 일부이다. 이종성 단백질을 인코딩하는 서열 및 바람직하게는 이종성 단백질을 인코딩하는 이러한 서열(들)을 포함하는 발현 카세트는, 예를 들어 본 명세서에 규정된 아데노바이러스 게놈의 결실 영역 내에 삽입될 수 있다. 예시적 이종성 단백질은 서열번호 74에 따른 폴리펩타이드 또는 서열번호 74에 적어도 85% 서열 동일성을 갖는 그의 변이체이다.

제2 양상에서, 본 발명은 아데노바이러스를 인코딩하는 단리된 폴리뉴클레오타이드를 제공하고, 이는 바람직하게는 서열번호 1 내지 10 중 어느 하나에 따른 아데노바이러스 게놈 또는 각각 서열번호 1 내지 10에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하여, 제1 양상의 폴리뉴클레오타이드를 포함한다.

바람직한 실시형태에서, 이는 바람직하게는 게놈 영역/유전자 E1A, E1B, E2A, E2B, E3 및 E4 중 하나 이상이 부재하는 서열번호 1 내지 10 중 어느 하나에 따른 아데노바이러스 게놈을 포함하는 복제-불능 아데노바이러스를 인코딩한다.

가장 바람직하게는, 이는 바람직하게는 서열번호 1 내지 10 중 어느 하나에 따른 아데노바이러스 게놈 또는 각각 서열번호 1 내지 10에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하고, 바람직하게는 하나 이상의 이종성 단백질 또는 그의 단편이 삽입되는 (전달체 아데노바이러스) 재조합 아데노바이러스를 인코딩한다. 바람직하게는, 하나 이상의 이종성 단백질 또는 그의 단편은 게놈 영역/유전자 E1A, E1B, E2A, E2B, E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, E3 ORF9, E4 ORF6/7, E4 ORF6, E4 ORF5, E4 ORF4, E4 ORF3, E4 ORF2 및 E4 ORF1, 더욱 바람직하게는 E1, E3 및/또는 E4 중 하나 이상을 대체함으로써, 삽입된다. 이종성 단백질 또는 그의 단편은 바람직하게는 발현 카세트의 일부로서 삽입된다. 선택적으로, 전달체 아데노바이러스는 또한 본원에 기재된 바와 같이 복제-불능, 즉, 게놈 영역/유전자 E1A, E1B, E2A, E2B, E3 및 E4 중 하나 이상이 부재한다.

예시적 실시형태에서, 본 발명은 아데노바이러스를 인코딩하는 단리된 폴리뉴클레오타이드를 제공하고, 이는 서열번호 72 또는 73에 따른 폴리뉴클레오타이드 또는 각각 서열번호 72 또는 73에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함한다.

바람직한 실시형태에서, 아데노바이러스 게놈 변이체 각각의 서열번호 1에 적어도 85%, 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성 대신, 서열번호 2에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 서열번호 3에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 4에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 5에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 6에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 7에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 8에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성, 각각의 서열번호 9에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성 또는 각각의 서열번호 10에 적어도 90% 및 바람직하게는 적어도 95%, 96%, 97%, 98%, 99%, 99.5 또는 99.9% 서열 동일성을 갖는다 (상기에 규정된 바와 같은 결실을 고려하는 경우).

일 실시형태에서, 제2 양상의 단리된 폴리뉴클레오타이드는 재조합 아데노바이러스를 인코딩하고, 재조합 아데노바이러스의 적어도 하나의 아데노바이러스 게놈 영역은 상기에 규정된 바와 같은 헥손 HVR 또는 헥손 단백질을 포함하지 않는 아데노바이러스로부터 유래된다 (키메라 아데노바이러스). 바람직하게는, 키메라 아데노바이러스는 대체로 또는 바람직하게는 본 명세서에 규정된 바와 같은 헥손 HVR 또는 헥손 단백질 및 선택적으로 또한 펜톤 및/또는 섬유 단백질에 대해서만 키메라이다. 즉, 폴리뉴클레오타이드는 상기에 규정된 바와 같은 헥손 HVR 또는 헥손 단백질 및 선택적으로 또한 상기에 규정된 바와 같은 펜톤 및/또는 섬유 단백질을 인코딩하나, 하나 이상의, 바람직하게는 다른 모든 게놈 영역은 상이한, 특히 서열번호 1 내지 10에 따른 아데노바이러스와 상이한 아데노바이러스로부터 유래한다. 상이한 아데노바이러스는 바람직하게는 상이한 숙주, 더욱 바람직하게는 인간 아데노바이러스에 자연적으로 존재하는 것이다. 이러한 폴리뉴클레오타이드는 바람직하게는 또한 상기에 규정된 바와 같은 하나 이상의 이종성 비-아데노바이러스 단백질 또는 그의 단편을 인코딩한다. 따라서, 하나 이상의 이종성 비-아데노바이러스 유전자는 키메라 아데노바이러스의 아데노바이러스 게놈 내에 삽입된다. 따라서, 키메라 아데노바이러스의 아데노바이러스 게놈은 상기에 규정된 바와 같은 헥손 HVR 또는 헥손 단백질을 인코딩하는 DNA 및 선택적으로 상기에 규정된 바와 같은 펜톤 및/또는 섬유 단백질을 인코딩하는 DNA를 제외하고, 비 유인원 아데노바이러스, 예를 들어 인간 아데노바이러스, 바람직하게는 비 유인원, 예를 들어 인간 전달체 아데노바이러스로부터 유래된 것이다.

일반적으로 아데노바이러스는 복제-불능인 것이 바람직하다. 결과적으로, 아데노바이러스가 게놈 영역 E1A, E1B, E2A, E2B, E3 및 E4 중 하나 이상이 부재하거나, 내부에 결실 및/또는 돌연변이를 포함함으로써, 그에 의해 인코딩되는 게놈 영역 또는 발현 산물이 비 기능성이 되는 것이 바람직하다.

특히 바람직한 일 실시형태에서, 그의 모든 변이체에서 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드는 기능적으로 손상된 IVa2 유전자, 바람직하게는 그 내부에 결실 또는 널 돌연변이 (null-mutation)를 가질 수 있다. 이러한 유전자는 바이러스 DNA 패킹 (packing)에 관여하고, 그 손상은 바이러스-유사 입자의 생성을 유발한다. 이러한 실시형태에서, 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드는 바람직하게는 하나 이상의 비-아데노바이러스 B 세포 에피토프 및/또는 T 세포 에피토프를 인코딩한다.

제3 양상에서, 본 발명은 제1 또는 제2 양상의 폴리뉴클레오타이드에 의해 인코딩되는 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드를 제공한다. 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드는 적어도, 상기에 규정된 바와 같은 HVR을 갖는 헥손, 바람직하게는 상기에 규정된 바와 같은 헥손 단백질 및 선택적으로 또한 상기에 규정된 펜톤 및/또는 섬유 단백질을 포함한다.

적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드는 세포내에서의 발현에 의해 획득될 수 있다. 발현된 폴리펩타이드(들)는 선택적으로 표준 기법을 사용하여 정제될 수 있다. 예를 들어, 세포를 물리적으로 또는 삼투압 충격에 의해 용해시킨 후, 침전 및 크로마토그래피 단계에 적용할 수 있으며, 그 특성 및 순서는 회수될 특정 재조합 물질에 따라 상이할 것이다. 대안적으로, 발현된 폴리펩타이드 (들)는 단백질 발현 기술에 공지된 바와 같이 재조합 세포가 배양된 배양 배지에 분비되고, 이로부터 회수될 수 있다.

제4 양상에서, 본 발명은 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드 및/또는 제3 양상의 아데노바이러스 캡시드 폴리펩타이드를 포함하는 아데노바이러스 (또한 본 명세서에서 아데노바이러스 벡터 또는 아데노바이러스 벡터로 언급됨)를 제공한다. 따라서, 아데노바이러스는, 예를 들어, 상기에 규정된 바와 같이, 서열번호 1 내지 10 중 어느 하나에 의해 인코딩되는 아데노바이러스 또는 재조합 아데노바이러스, 예컨대, 전달체 또는 키메라 아데노바이러스일 수 있다. 바람직하게는, 아데노바이러스는 단리된 아데노바이러스이다.

예시적 실시형태에서, 본 발명은 각각 서열번호 72 또는 73에 따른 폴리뉴클레오타이드 또는 서열번호 72 또는 73에 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 아데노바이러스를 제공한다.

아데노바이러스는 제1 또는 제2 양상의 폴리뉴클레오타이드를 포함할 수 있거나 포함하지 않을 수 있다. 이러한 폴리뉴클레오타이드가 아데노바이러스에 포함되지 않은 경우, 이는 이식형으로 제공된다 (즉, 아데노바이러스 내에 혼입된 아데노바이러스 게놈에 존재하지 않는 유전적 요소에 의함). 이는 일반적으로 보조 작제물 (예를 들어, 플라스미드 또는 바이러스) 또는 패키징 숙주 세포 (본 명세서에 기재된 바와 같은 보완 세포)의 게놈 또는 그 내부의 보조 작제물에 의해 제공된다. 이식형으로 제공되는 폴리뉴클레오타이드가 이들 폴리뉴클레오타이드의 상동체 또는 다른 서열 변이체를 포함하여, 아데노바이러스 내에 혼입된 게놈 내에 포함되지 않은 것이 더욱 바람직하다. 예를 들어, 이식형으로 제공되는 폴리뉴클레오타이드가 헥손, 펜톤 및/또는 섬유 유전자를 포함하는 경우, 아데노바이러스에 혼입된 게놈은 각각 헥손, 펜톤 및/또는 섬유 단백질을 인코딩하는 임의의 폴리뉴클레오타이드를 포함하지 않는다. 가장 바람직하게는, 이식형으로 제공되는 폴리뉴클레오타이드는 제3 양상에서 규정된 바와 같은 적어도 하나의 아데노바이러스 캡시드 폴리펩타이드, 즉 제1 또는 제2 양상에서 규정된 바와 같은 HVR을 갖는 헥손, 바람직하게는 제1 또는 제2 양상에서 규정된 바와 같은 헥손 단백질, 및 선택적으로 제1 또는 제2 양상에서 규정된 바와 같은 펜톤 및/또는 섬유 단백질을 인코딩한다.

숙주, 예를 들어 인간 또는 다른 포유류 세포에 유전자를 전달하기 위한 아데노바이러스 벡터의 작제시, 다양한 아데노바이러스 핵산 서열이 사용될 수 있다. 예를 들어, 재조합 바이러스의 일부를 형성하는 아데노바이러스 서열로부터 아데노바이러스 지연 초기 유전자 E3의 전부 또는 일부가 제거될 수 있다. 유인원 E3의 기능은 재조합 바이러스 입자의 기능 및 생성과 관련이 없는 것으로 여겨진다. 일부 실시형태에서, 더욱 바람직하게는 이 영역, 전체 E4 영역의 기능에서의 중복성으로 인해 E4 유전자의 적어도 ORF6 영역이 결실된 아데노바이러스 벡터가 또한 작제될 수 있다. 본 발명의 또 다른 벡터는 지연 초기 유전자 E2a에 결실을 포함한다. 유인원 아데노바이러스 게놈의 후기 유전자 L1 내지 L5 중 임의의 것에도 결실이 이루어질 수 있다. 유사하게, 중간 유전자 IX 및 IVa2에서의 결실은 일부 목적에 유용할 수 있다. 다른 결실은 다른 구조적 또는 비 구조적 아데노바이러스 유전자에 이루어질 수 있다. 상기 논의된 결실은 개별적으로 사용될 수 있으며, 즉, 본 발명에 사용하기 위한 아데노바이러스 서열은 단일 영역에만 결실을 포함할 수 있다. 대안적으로, 생물학적 활성을 파괴하는데 효과적인 전체 유전자 또는 그의 일부의 결실은 임의의 조합으로 사용될 수 있다. 예를 들어, 아데노바이러스 서열은 E3 등의 결실의 유무에 관계없이 El 및 E4 영역 또는 El, E2a 및 E3 영역 또는 E1 및 E3 영역 또는 El, E2a 및 E4 영역의 결실을 가질 수 있다. 적절한 결과를 획득하기 위해, 이러한 결실은 온도 감응성 돌연변이와 같은 다른 아데노바이러스 유전자 돌연변이와 조합하여 사용될 수 있다.

임의의 필수 아데노바이러스 서열 (예를 들어, Ela, Elb, E2a, E2b, E4 ORF6, L1 또는 L4로부터 선택된 영역)이 부재하는 아데노바이러스 벡터는, 아데노바이러스 입자의 바이러스 감염성 및 증식에 필요한 결손 아데노바이러스 유전자 산물의 존재 하에서 배양될 수 있다. 이들 보조 기능은 하나 이상의 보조 작제물 (예를 들어, 플라스미드 또는 바이러스) 또는 패키징 숙주 세포 (본 명세서에 기재된 바와 같은 보완 세포)의 존재하에 아데노바이러스 벡터를 배양함으로써 제공될 수 있다. 예를 들어, WO96/13597의 "최소" 인간 아데노바이러스 벡터의 제조에 대해 기재된 기법을 참조한다.

유용한 보조 작제물은 벡터 및 벡터가 형질감염된 세포에 의해 발현되지 않고/거나, 결실된 각각의 유전자를 보완하는 선택된 아데노바이러스 유전자 서열을 포함한다. 일 실시형태에서, 보조 작제물은 복제 결함이고, 필수적이고 선택적으로 추가의 아데노바이러스 유전자를 포함한다.

보조 작제물은 또한 문헌[Wu et al, J. Biol. Chem., 264: 16985-16987 (1989); K. J. Fisher and J. M. Wilson, Biochem. J., 299: 49 (April 1, 1994)]에 기재된 바와 같은 다가 양이온성 접합체로 형성될 수 있다. 보조 작제물은 선택적으로 리포터 유전자를 포함할 수 있다. 다수의 이러한 리포터 유전자는 당 업계에 공지되어 있다. 아데노바이러스 벡터상의 전이유전자와 상이한 보조 작제물 상에 리포터 유전자의 존재에 의해 아데노바이러스 및 보조 작제물 둘 모두를 독립적으로 모니터링할 수 있다. 이러한 제2 리포터는 정제시에 생성된 재조합 아데노바이러스 및 보조 작제물 사이의 분리를 용이하게 하기 위해 사용될 수 있다. 바람직한 보조 작제물은 보조 바이러스이다.

본 명세서의 바람직한 실시형태와 관련하여 기재된 임의의 유전자에서 결실된 재조합 아데노바이러스 (Ad)를 생성하기 위해, 결실된 유전자 영역의 기능이 바이러스의 복제 및 감염성에 필수적인 경우, 바람직하게는 보조 작제물 또는 세포, 즉 보완 또는 패키징 세포에 의해 재조합 바이러스에 제공된다. 다양한 환경에서, 인간 E1을 발현하는 작제물/세포를 사용하여 재조합 아데노바이러스를 생성하는데 사용되는 벡터를 이식 보완할 수 있다. 이는 본 발명의 폴리뉴클레오타이드 서열과 현재 이용 가능한 패키징 작제물/세포에 존재하는 인간 아데노바이러스 E1 서열 사이의 다양성으로 인해, 현재 인간 E1 포함 작제물/세포의 사용이 복제 및 생성 과정에서 복제 가능한 아데노바이러스의 생성을 방지할 것이기 때문에 특히 유리하다. 그러나, 특정 상황에서, E1-결실된 재조합 아데노바이러스의 생성을 위해 E1 유전자 산물을 발현하는 작제물/세포를 이용하는 것이 바람직할 것이다.

적절한 경우, 본 명세서에 제공된 서열을 이용하여, 예를 들어 HeLa 세포와 같은 선택된 모 세포주에서 발현을 위한 프로모터의 전사 제어 하에, 최소한 서열번호 1 내지 10 중 어느 하나에 따른 아데노바이러스로부터 아데노바이러스 E1 유전자를 발현하는 보조 작제물/세포 또는 세포주를 생성할 수 있다. 이 목적을 위해 유도성 또는 항시적 프로모터가 사용될 수 있다. 프로모터의 예는 예를 들어 본 명세서에 기재된 실시예에 제공된다. 이러한 E1-발현 세포는 재조합 아데노바이러스 E1 결실 벡터의 생성에 유용하다. 추가적으로 또는 대안적으로, 본 발명은 하나 이상의 아데노바이러스 유전자 산물, 예를 들어, Ela, Elb, E2a 및/또는 E4 ORF6, 바람직하게는 Ad5 E4 ORF6을 발현하는 작제물/세포를 제공하며, 이는 필수적으로, 재조합 아데노바이러스 벡터의 생성에 사용되는 것과 동일한 절차를 사용하여 작제될 수 있다. 이러한 작제물/세포는 이러한 산물을 인코딩하는 필수 유전자가 결실된 아데노바이러스 벡터를 이식 보완하거나, 보조-의존적 바이러스 (예를 들어, 아데노-연관 바이러스)의 패키징에 필요한 보조 기능을 제공하는데 이용될 수 있다.

일반적으로, 형질감염에 의해 아데노바이러스 벡터를 전달할 때, 벡터는 약 0.1 μg 내지 약 100 μg DNA 및 바람직하게는 약 10 내지 약 50 μg DNA 내지 약 1 x 10⁴개의 세포 내지 약 1 x 10³개의 세포 및 바람직하게는 약 10⁵개의 세포의 양으로 전달된다. 그러나, 선택된 벡터, 전달 방법 및 선택된 숙주 세포와 같은 인자를 고려하여 숙주 세포에 대한 벡터 DNA의 상대적인 양이 조절될 수 있다. 벡터를 숙주 세포 내로 도입하는 것은, 예를 들어 CaPO₄ 형질감염 또는 전기 천공 법을 사용한 형질감염 및 감염을 포함하여, 당 업계에 공지되어 있거나, 본 명세서에 개시된 바와 같은 임의의 수단에 의해 달성될 수 있다.

적절한 재조합 아데노바이러스의 작제 및 조립을 위해, 하나의 예에서, 보조 작제물의 존재하에 시험관내에서 아데노바이러스 벡터를 패키징 세포주 내로 형질감염시켜, 보조 및 아데노바이러스 벡터 서열 사이에 상동성 재조합이 유발되도록 할 수 있으며, 이에 의해, 당 업계에 널리 공지된 바와 같이, 벡터 내의 아데노바이러스-전이유전자 서열이 복제되고, 비리온 캡시드로 패키징될 수 있음으로서, 재조합 바이러스 벡터 입자를 생성할 수 있다. 본 발명의 재조합 아데노바이러스는 예를 들어 선택된 전이유전자를 선택된 숙주 세포 내로 전달하는 단계에 유용하다.

바람직한 실시형태에서, 제4 양상의 아데노바이러스는 인간 대상체의 5% 미만에서 혈청 내에 다량 존재하고, 바람직하게는 인간 대상체에서 혈청 내에 다량 존재하지 않으며, 가장 바람직하게는 비인간 대형 유인원 아데노바이러스, 더욱 바람직하게는 서열번호 1 내지 10에 따른 하나 이상의, 특히 모든 아데노바이러스와 이전에 접촉되지 않은 인간 대상체에서 혈청 내에 다량 존재하지 않는다. 이와 관련하여, 바람직하게는, 인간 대상체는 유럽인, 아프리카 원주민, 아시아인, 미국 원주민 및 오세아니아 원주민으로부터 선택되는 인종 그룹에 속한다. 인간 대상체의 인종 기원을 확인하는 방법은 당 업계에 포함된다 (예를 들어, WO2003/102236 참조).

재조합 아데노바이러스의 추가의 바람직한 실시형태에서, 아데노바이러스 DNA는 포유류 표적 세포에 유입될 수 있으며, 즉 감염성이다. 본 발명의 감염성 재조합 아데노바이러스는 또한 본 명세서에 기재된 바와 같은 백신 및 유전자 요법으로 사용될 수 있다. 따라서, 다른 실시형태에서, 재조합 아데노바이러스는 표적 세포로 전달하기 위한 분자를 포함하는 것이 바람직하다. 바람직하게는, 표적 세포는 포유류 세포, 예를 들어 비인간 대형 유인원 세포, 설치류 세포 또는 인간 세포이다. 예를 들어, 표적 세포 내로 전달하기 위한 분자는 바람직하게는 발현 카세트 내의 본 명세서에 규정된 이종성 단백질 (즉, 이종성 유전자)을 인코딩하는 폴리뉴클레오타이드일 수 있다. 아데노바이러스의 게놈 내로 발현 카세트를 도입하는 방법은 당 업계에 널리 공지되어 있다. 하나의 예에서, 예를 들어 이종성 유전자를 인코딩하는 발현 카세트를 포함하는 본 발명의 재조합 아데노바이러스는 E1A, E1B, E2A, E2B, E3 및 E4로부터 선택된 아데노바이러스의 게놈 영역을 상기 발현 카세트로 대체함으로써 생성될 수 있다. 본 발명의 아데노바이러스의 게놈 영역 E1A, E1B, E2A, E2B, E3 및 E4는 인간 Ad5와 같이 주석의 공지된 아데노바이러스 게놈과의 정렬에 의해 용이하게 확인될 수 있다 (문헌[Birgitt Taeuber 및 Thomas Dobner, Oncogene (2001) 20, p. 7847 -7854; 및 또한: Andrew J. Davison, et al., "Genetic content and evolution of adenoviruses", Journal of General Virology (2003), 84, p. 2895-2908] 참조).

표적 세포 내로 전달하기 위한 분자는 바람직하게는 이종성 폴리뉴클레오타이드이지만, 또한 바람직하게는 치료적 또는 진단적 활성을 갖는 폴리펩타이드 또는 작은 화학 화합물일 수 있다. 특히 바람직한 일 실시형태에서, 표적 세포로 전달하기 위한 분자는 아데노바이러스 5' 역위 말단 반복 서열 (ITR) 및 3' ITR을 포함하는 이종성 폴리뉴클레오타이드이다. 예를 들어 패키징 세포에서 재조합 아데노바이러스가 생성되는 경우, 캡시드가 분자 주위에 형성되고, 이를 패키징할 수 있는 분자의 분자 크기가 선택되어야 한다는 것이 당업자에게 명백할 것이다. 따라서, 바람직하게는 이종성 유전자는 예를 들어 최대 7000 및 최대 8000개의 염기 쌍을 가질 수 있는 미니유전자이다.

제5 양상에서, 본 발명은 제1 또는 제2 양상의 폴리뉴클레오타이드에 의해 인코딩되는 바이러스-유사 입자 (VLP)를 제공한다. 따라서, VLP는 제3 양상에 따른 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드를 포함한다. 일 실시형태에서, VLP를 인코딩하는 폴리뉴클레오타이드는 결실된 Iva2 유전자를 갖거나, Iva2 유전자 내에 널-돌연변이를 갖는다.

하기 VLP의 규정에 따르면, 제5 양상의 VLP는 바이러스 게놈 DNA를 실질적으로 포함하지 않는다. 아데노바이러스 VLP를 포함하는 VLP는 백신화, 유전자 요법 또는 예를 들어 항암제의 약물 직접 전달을 위해 사용되어 왔다 (문헌[Chroboczek et al., ACTA ABP BIOCHIMICA POLONICA, Vol. 61, No. 3/2014]). 따라서, 제5 양상의 VLP는 하나 이상의 비-아데노바이러스 B 세포 및/또는 비-아데노바이러스 T 세포 에피토프, 유전자 요법을 위한 하나 이상의 비-아데노바이러스 유전자 및/또는 하나 이상의 약제학적 제제, 예를 들어 항암 제제를 포함할 수 있다. 일 실시형태에서, VLP는 하나 이상의 비-아데노바이러스 B 세포 에피토프를 혼입시키고, 바람직하게는 제시하고/거나, 하나 이상의 비-아데노바이러스 T 세포 에피토프를 혼입시킨다.

제6 양상에서, 본 발명은 제1 또는 제2 양상의 폴리뉴클레오타이드를 포함하는 벡터를 제공한다. 바람직한 실시형태에서, 벡터는 플라스미드 벡터, 예를 들어 발현 벡터이다. 플라스미드 벡터는 본 명세서에 기재된 바와 같은 재조합 아데노바이러스를 생성하기 위해 유리하게 사용될 수 있다. 본 발명의 신규한 헥손, 펜톤 및 섬유 단백질 및 VA RNA의 서열 정보가 제공되므로, 상기 재조합 아데노바이러스는 예를 들어 제1 또는 제2 양상 및 임의의 다른 아데노바이러스 게놈 영역의 폴리뉴클레오타이드에 의해 인코딩되는 재조합 아데노바이러스를 작제함으로써 획득될 수 있다. 재조합 아데노바이러스의 작제 방법은 당 업계에 널리 공지되어 있다. 재조합 아데노바이러스의 제조를 위해 유용한 기법은, 예를 들어 문헌[Graham & Prevec, 1991 In Methods in Molecular Biology: Gene Transfer and Expression Protocols, (Ed. Murray, EJ.), p. 109; and Hitt et al., 1997 "Human Adenovirus Vectors for Gene Transfer into Mammalian Cells" Advances in Pharmacology 40:137-206]에 검토되어 있다. WO 2006/086284에 추가의 방법이 기재되어 있다.

제1 또는 제2 양상의 폴리뉴클레오타이드를 발현시키기 위해, 바람직하게는 발현 카세트에 의해, 전사를 유도하는 강한 프로모터를 포함하는 발현 벡터로 상기 폴리뉴클레오타이드를 서브클로닝 (subcloning)할 수 있다. 적합한 박테리아 프로모터는 예를 들어 E. 콜라이 (E. coli), 바실러스 (Bacillus) 종 및 살모넬라 (Salmonella)에서와 같이 당 업계에 널리 공지되어 있으며, 이러한 발현 시스템용 키트는 시중에서 구입할 수 있다. 유사하게 포유류 세포, 효모 및 곤충 세포에 대한 진핵생물 발현 시스템은 당 업계에 널리 공지되어 있고, 또한 시중에서 구입할 수 있다. 발현 카세트에 대한 자세한 내용은 하기를 참조한다.

유전자 정보를 세포 내로 운반하는데 유용한 특정 발현 벡터는 특별히 중요하지 않다. 진핵세포 또는 원핵세포에서의 발현에 사용되는 임의의 통상적인 벡터가 사용될 수 있다. 표준 박테리아 발현 벡터는 플라스미드 예컨대, pBR322 기반 플라스미드, pSKF, pET23D 및 융합 발현 시스템 예컨대, GST 및 LacZ를 포함하지만, 당업자에게 유용하게 사용될 수 있는 많은 것이 공지되어 있다. 진핵생물 바이러스로부터의 조절 요소를 포함하는 발현 벡터는 통상적으로 진핵생물 발현 벡터, 예를 들어 SV40 벡터, 유두종 바이러스 벡터 및 엡스타인-바르 바이러스 (Epstein-Barr virus)로부터 유래된 벡터에 사용된다. 다른 예시적인 진핵생물 벡터는 pMSG, pAV009/A.sup.+, pMTO10/A.sup.+, pMAMneo-5, 바큘로바이러스 (baculovirus) pDSVE, pcDNA3.1, pIRES 및 예를 들어 HCMV 즉시-초기 프로모터, SV40 조기 프로모터, SV40 후기 프로모터, 메탈로티오네인 프로모터, 쥣과동물 유선 종양 바이러스 프로모터, 라우스 육종 바이러스 프로모터, 폴리헤드린 프로모터, 또는 진핵 세포에서의 발현에 효과적인 것으로 밝혀진 다른 프로모터의 방향에 따라 단백질의 발현을 가능하게 하는 임의의 다른 벡터를 포함한다. 일부 발현 시스템은 티미딘 키나제, 하이그로마이신 B 포스포트랜스퍼라제 및 디하이드로폴레이트 환원효소와 같은 유전자 증폭을 제공하는 마커를 갖는다. 대안적으로, 유전자 증폭을 포함하지 않는 고 수율 발현 시스템이 또한 적합하다. 발현 벡터에 또한 포함될 수 있는 요소는 E. 콜라이에서 기능하는 레플리콘 (replicon), 재조합 플라스미드를 보유하는 박테리아의 선택을 가능하게 하는 약물 내성을 인코딩하는 유전자, 및 진핵생물 서열의 삽입을 가능하게 하기 위한 플라스미드의 비 필수 영역의 고유한 제한 부위를 포함한다. 선택된 특정 약물 내성 유전자는 중요하지 않으며, 당 업계에 공지된 많은 약물 내성 유전자 중 임의의 것이 적합하다. 원핵생물 서열은 필요에 따라 선택적으로, 진핵세포에서 DNA의 복제를 방해하지 않는 것으로 선택된다.

제7 양상에서, 본 발명은 (i) 애주번트, (ii) 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및 선택적으로 (iii) 약제학적으로 허용 가능한 부형제를 포함하는 조성물을 제공한다. 바람직하게는, 애주번트는 I형 사이토카인 수용체, II형 사이토카인 수용체, TNF 수용체, 전사 인자로서 작용하는 비타민 D 수용체 및 Toll-유사 수용체 1 (TLR1), TLR-2, TLR 3, TLR4, TLR5, TLR-6, TLR7 및 TLR9로 이루어진 군으로부터 선택된 수용체에 대한 작용제이다.

애주번트를 포함하는 조성물은 예를 들어 인간 대상체를 위한 백신으로서 사용될 수 있다. 예를 들어, 특정 수용체의 활성화는 면역 반응을 자극할 수 있다. 이러한 수용체는 당업자에게 공지되어 있으며, 예를 들어 사이토카인 수용체, 특히 I형 사이토카인 수용체, II형 사이토카인 수용체, TNF 수용체; 및 전사 인자로서 작용하는 비타민 D 수용체; 및 Toll-유사 수용체 1 (TLR1), TLR-2, TLR 3, TLR4, TLR5, TLR-6, TLR7 및 TLR9를 포함한다. 이러한 수용체에 대한 작용제는 애주번트 활성을 가지며, 즉 면역 자극성이다. 바람직한 실시형태에서, 조성물의 애주번트는 하나 이상의 Toll-유사 수용체 작용제일 수 있다. 더욱 바람직한 실시형태에서, 애주번트는 Toll-유사 수용체 4 작용제이다. 특히 바람직한 실시형태에서, 애주번트는 Toll-유사 수용체 9 작용제이다. 애주번트의 예를 위해 다음을 참조한다. 또한, 바람직한 약제학적으로 허용 가능한 부형제가 다음에 언급되어 있다.

제8 양상에서, 본 발명은 제1 또는 제2 양상의 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터를 포함하는 세포를 제공한다.

바람직하게는, 세포는, 상기에 설명된 바와 같이, 결실되거나, 비 기능성이 되어, 아데노바이러스가 복제-불능이 되는 적어도 하나의 아데노바이러스 유전자 또는 바람직하게는 모든 아데노바이러스 유전자를 발현하는 숙주 세포이다. 이러한 적어도 하나의 유전자의 발현에 의해, 숙주 세포에서 바람직하게는 그외에는 복제-불능인 아데노바이러스의 복제가 가능할 수 있다. 일 실시형태에서, 숙주 세포는 E1A, E1B, E2A, E2B, E3 및 E4로 이루어진 군으로부터 선택되는 적어도 하나의 아데노바이러스 유전자를 발현한다. 특히, 이러한 적어도 하나의 아데노바이러스 유전자는 아데노바이러스 게놈에서 결실되거나, 비 기능성이 된다. 이러한 보완 세포는 예를 들어, 전술된 유전자 산물 중 하나가 부재하므로, 이는 복제 불능인 아데노바이러스의 증식 및 구제를 위해 사용될 수 있다.

세포는 박테리아 세포, 예컨대 E. 콜라이 세포, 효모 세포, 예컨대 사카로마이세스 세레비지아에 (Saccharomyces cerevisiae) 또는 피키아 파스토리스 (Pichia pastoris), 식물 세포, 곤충 세포, 예컨대 SF9 또는 Hi5 세포 또는 포유류 세포 중에서 선택될 수 있다. 포유류 세포의 바람직한 예는 중국 햄스터 난소 (CHO) 세포, 인간 배아 신장 (HEK 293) 세포, HELA 세포, 인간 간세포 (예를 들어, Huh7.5), Hep G2 인간 간세포, Hep 3B 인간 간세포 등이다.

세포가 제1 또는 제2 양상에 따른 폴리뉴클레오타이드를 포함하는 경우, 이 폴리뉴클레오타이드는 (i) 그 자체로 무작위 분산되거나, (ii) 세포 게놈 또는 미토콘드리아 DNA에 혼입되어 세포에 존재할 수 있다.

추가의 바람직한 실시형태에서, 세포는 E1a, E1b, E2a, E2b, E4, L1, L2, L3, L4 및 L5로 이루어진 군으로부터 선택된 적어도 하나의 아데노바이러스 유전자를 발현하는 숙주 세포, 바람직하게는 293 세포 또는 PER.C6™ 세포이다.

박테리아, 포유류, 효모 또는 곤충 세포주를 생성하기 위해 표준 형질감염 방법을 사용할 수 있다. 외래 폴리뉴클레오타이드 서열을 숙주 세포 내로 도입하기 위한 임의의 공지된 절차가 사용될 수 있다. 예를 들어, 시판되는 리포좀 기반 형질감염 키트, 예컨대 Lipofectamine™ (Invitrogen), 시판되는 지질 기반 형질감염 키트, 예컨대 Fugene (Roche Diagnostics), 폴리에틸렌 글리콜 기반 형질감염, 인산칼슘 침전, 유전자 총 (biolistic), 전기천공법, 또는 바이러스 감염 및 클로닝된 게놈 DNA, cDNA, 합성 DNA 또는 다른 외래 유전 물질을 숙주 세포 내로 도입하기 위한 임의의 다른 널리 공지된 방법이 사용될 수 있다. 사용된 특정 유전자 조작 절차는 수용체를 발현할 수 있는 숙주 세포 내로 적어도 하나의 유전자를 성공적으로 도입할 수 있으면 된다.

세포의 추가 실시형태는 상기 본 발명의 제4 양상과 관련하여 기재되어 있다.

제9 양상에서, 본 발명은 질병의 치료 또는 예방에 사용하기 위한 제1 또는 제2 양상의 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및/또는 제7 양상의 조성물을 제공한다. 일 실시형태에서, 치료 또는 예방은 백신화에 의한 것이다. 다른 실시형태에서, 치료는 유전자 요법에 의한 것이다. 백신화와 관련하여, 질병은 바람직하게는 본 명세서에 기재된 바와 같은 병원체에 의해 유발되는 감염성 질병, 또는 바람직하게는 건강한 세포에 의해 발현되지 않는 항원을 발현하는 질병 세포 (예를 들어, 종양 관련 항원을 발현하는 종양 세포)를 특징으로 하는 비 감염성 질병이다. 유전자 요법과 관련하여, 질병은 유전자 또는 단백질의 기능의 상실 또는 획득을 야기하는 하나 이상의 체세포 돌연변이에 의해 유발되는 유전성 질병이다.

아데노바이러스는 유전자 요법 및 백신으로서 유용하다는 것이 널리 공지되어 있다. 전임상 및 임상 연구에 의해 이 시스템을 사용하여 벡터 설계, 강력한 항원 발현 및 보호 면역의 가능성이 입증되었다. 따라서, 바람직한 사용 실시형태는 예를 들어 인단 대상체를 위한 백신화이다. 백신화를 위한 아데노바이러스의 사용 및 제조 방법에 대한 상세한 지침은 기술분야에 포함되어 있고, 당업자에게 공지된 방대한 문헌으로서 제공된다. 예를 들어, 비인간 대형 유인원 아데노바이러스를 기반으로 한 바이러스 벡터는 유전자 백신의 개발을 위한 인간 유래 Ad 벡터의 사용에 대한 대안으로 나타난다 (문헌[Farina SF, J Virol. 2001 Dec;75(23):11603-13.; Fattori E, Gene Ther. 2006 Jul;13(14):1088-96]). 비인간 대형 유인원으로부터 단리된 아데노바이러스는 인간 유래의 세포에서 그의 효율적인 증식에 의해 입증된 바와 같이 인간으로부터 단리된 아데노바이러스와 밀접하게 연관된다. 그러나, 인간 및 비인간 유인원 아데노바이러스는 연관되어 있기 때문에, 두 바이러스 종 사이에 일정 정도의 혈청 교차 반응성이 있을 수 있거나, 부재할 수 있다. 이러한 가정은 침팬지 아데노바이러스를 단리하여, 특성화한 경우에 확인되었다. 따라서, 본 발명에 따른 비인간 대형 유인원 아데노바이러스는 인간에서 인간 아데노바이러스의 통상적인 혈청형에 대한 기 존재하는 면역과 관련된 부작용을 감소시킴으로써, 예를 들어 면역화 및/또는 유전자 요법에 사용될 수 있는 중요한 의학적 툴을 위한 기반을 제공한다.

이는 헥손, 펜톤 및 섬유 단백질을 포함하는 아데노바이러스 캡시드 단백질의 신규한 서열, 특히 가장 표면에 노출된 아데노바이러스 에피토프를 나타내는 신규한 헥손 HVR 서열에 기인한다. 따라서, 캡시드 단백질 및 특히 본 발명에 따른 헥손 HVR에 특이적인 중화 항체는 인간 혈액 혈청에 존재하지 않거나, 매우 소수 존재할 것으로 예상된다. 따라서, 신규한 서열의 하나의 이점은 이것이, 예를 들어 의료 목적을 위해 조작된 종래의 아데노바이러스를 향상시키기 위해 사용될 수 있다는 것이다. 예를 들어, 이러한 서열은, 예를 들어, 인간에서 혈청 내 존재량이 감소된 개선된 재조합 아데노바이러스 (키메라 아데노바이러스)를 획득하기 위해, 상이한 아데노바이러스, 예를 들어 종래 아데노바이러스의 주요 구조적 캡시드 단백질 중 하나 이상 또는 특히 단지 헥손 HVR을 대체/치환하기 위해 사용될 수 있다. 기재된 바와 같이 재조작된 신규 서열 및 이에 따른 아데노바이러스는 투여시 인간에서 임의의 유의한 억제성 면역 반응을 유발하지 않을 것이기 때문에, 그의 전체 형질도입 효율 및 감염성이 향상될 것이다. 따라서, 이러한 개선된 아데노바이러스는 숙주 세포로의 유입 및 항원의 발현이 임의의 유의한 역가의 중화 항체에 의해 방해받지 않기 때문에 더욱 효과적인 백신이 될 것으로 예상된다.

백신은 애주번트를 포함하는 것이 바람직하다. 바람직한 면역학적 애주번트가 본 명세서에 언급되어 있으며, 이러한 백신에 사용될 수 있다.

백신화에 사용되는 경우, 본 발명의 재조합 아데노바이러스는 바람직하게는 1 x 10⁸ 내지 1 x 10¹¹ 바이러스 입자 (즉, 1 x 10⁸, 5 x 10⁸, 1 x 10⁹, 5 x 10⁹, 1 x 10¹⁰, 2.5 x 10¹⁰ 또는 5 x 10¹⁰개의 입자)의 면역학적 및/또는 예방적으로 유효한 투여량으로 투여될 수 있다.

또한, 부스팅 (boosting)이 필요한 백신화의 경우, "이종성 프라이밍 (priming)-부스팅" 방법론을 적용하는 것이 바람직하다: 백신화에서, 제1 양상 또는 제2 양상의 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및/또는 제7 양상의 조성물은 프라이밍 또는 부스팅, 특히 이종성 프라이밍-부스팅 백신화에 사용될 수 있다. 이종성 프라이밍-부스팅의 2개의 상이한 백신의 바람직한 실시형태에서, 예를 들어 제1 또는 제2 양상의 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및/또는 제7 양상의 조성물은 예를 들어 인간에서 항체 부재 또는 중화 항체로 인한 부스팅 백신으로서 사용된다.

본 발명에 따른 폴리뉴클레오타이드 또는 재조합 아데노바이러스 단백질 또는 그의 단편을 사용하여 제조된 재조합 아데노바이러스는 숙주 세포를 폴리뉴클레오타이드, 예를 들어 DNA로 형질도입하는데 사용될 수 있다. 따라서, 숙주 세포에서 임의의 지정 단백질 또는 폴리펩타이드를 발현시키기 위해, 감염성 (즉, 숙주 세포로 유입될 수 있음)일지라도, 바람직하게는 복제 결합인 아데노바이러스를 제조할 수 있다. 따라서, 바람직한 실시형태에서, 본 발명에 따른 사용에 열거된 요법은 유전자 요법이다. 유전자 요법은 생체내, 생체외 또는 시험관내 유전자 요법일 수 있다. 바람직하게는 이는 체세포 유전자 요법이다. 본 발명에 따른 단리된 폴리뉴클레오타이드, 단리된 단백질, 벡터, 재조합 아데노바이러스 및/또는 약제학적 조성물이 유전자 요법에 사용되고, 치료될 대상체에 투여되는 경우, 이는 치료로 인해 환자의 하나 이상의 세포가 형질감염, 즉 형질도입되도록 충분히 큰 투여량으로 투여되는 것이 바람직하다. 본 발명에 따른 재조합 아데노바이러스 및/또는 약제학적 조성물이 본 명세서에 개시된 임의의 바람직한 투여 수단에 의해 투여되는 경우, 바람직하게는 1 x 10⁸ 내지 5 x 10¹¹ 바이러스 입자 (즉, 1 x 10⁸, 5 x 10⁸, 1 x 10⁹, 5 x 10⁹, 1 x 10¹⁰, 2.5 x 10¹⁰, 5 x 10¹⁰, 1 x 10¹¹ 또는 가장 바람직하게는, 5 x 10¹¹개의 입자)의 유효한 투여량이 투여된다. 바람직한 실시형태에서, 본 발명의 재조합 아데노바이러스에 포함되는 바람직하게는 이종성 폴리뉴클레오타이드는 대상체의 숙주 세포에서 단백질 또는 폴리펩타이드를 발현할 수 있으며, 단백질 또는 폴리펩타이드는 상기 숙주 세포로부터의 단백질 또는 폴리펩타이드의 분비에 영향을 미치는 신호 펩타이드를 포함한다. 예를 들어, 특정 단백질이 필요한 환자는 이 단백질의 분비 가능한 형태를 인코딩하는 cDNA를 포함하는 본 발명의 아데노바이러스를 사용하여 치료될 수 있다.

본 발명의 사용의 추가 실시형태에서, 제1 또는 제2 양상의 폴리뉴클레오타이드, 제3 양상의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제4 양상의 아데노바이러스, 제5 양상의 바이러스-유사 입자 또는 제6 양상의 벡터 및/또는 제7 양상의 조성물 (이하, 본 발명에 따른 약제로 지칭됨)은 하나 이상의 약제학적으로 허용 가능한 희석제; 담체; 충전제, 결합제, 윤활제, 활택제, 붕해제 및 흡착제를 포함하는 부형제; 및/또는 보존제를 추가로 포함하도록 제형화된다.

본 발명에 따른 약제는 경구, 직장, 위내 및 비경구 투여, 예를 들어 정맥내, 근육내, 비강내, 피내, 피하 및 유사한 투여 경로를 포함하는 널리 공지된 다양한 경로에 의해 투여될 수 있다. 비경구, 근육내 및 정맥내 투여가 바람직하다. 바람직하게는 본 발명에 따른 약제는 시럽, 주입 또는 주사 용액, 정제, 캡슐, 캡슬렛, 로젠지 (lozenge), 리포좀, 좌약, 석고, 반창고, 지연 캡슐, 분말, 또는 서방출 제형으로서 제형화된다. 바람직하게는 희석제는 물, 완충액, 완충 염 용액 또는 염 용액이고, 담체는 바람직하게는 코코아 버터 및 비테베솔 (vitebesole)로 이루어진 군으로부터 선택된다.

본 발명의 사용 동안 본 발명에 따른 약제의 투여를 위한 특히 바람직한 약제학적 형태는 주사용으로 적합한 형태이며, 멸균 주사용 용액 또는 분산액의 즉석 제조를 위한 멸균 수용액 또는 분산액 및 멸균 분말을 포함한다. 통상적으로, 이러한 용액 또는 분산액은 예를 들어 물-완충 수용액, 예를 들어 생체적합성 완충액, 에탄올, 폴리올, 예컨대 글리세롤, 프로필렌 글리콜, 폴리에틸렌 글리콜, 이들의 적합한 혼합물, 계면활성제 또는 식물성 오일을 포함하는 용매 또는 분산 매질을 포함할 것이다.

주입 또는 주사 용액은, 항균제 또는 항진균제와 같은 보존제, 예를 들어, 파라벤, 클로로부탄올, 페놀, 소르브산 또는 티머살의 첨가에 제한되는 것은 아니지만 이를 포함한 수많은 당 업계에 공지된 기법에 의해 획득될 수 있다.

본 발명의 바람직한 희석제는 물, 생리학적으로 허용 가능한 완충액, 생리학적으로 허용 가능한 완충 염 용액 또는 염 용액이다. 바람직한 담체는 코코아 버터 및 비테베솔이다. 본 발명에 따른 다양한 약제학적 형태의 약제와 함께 사용될 수 있는 부형제는 하기 비 제한적 목록으로부터 선택될 수 있다:

a) 결합제, 예컨대 락토스, 만니톨, 결정질 소르비톨, 제2인산염, 인산칼슘, 당류, 미정질 셀룰로스, 카복시메틸 셀룰로스, 하이드록시에틸 셀룰로스, 폴리비닐 피롤리돈 등;

b) 윤활제, 예컨대 스테아르산마그네슘, 탈크, 스테아르산칼슘, 스테아르산아연, 스테아르산, 수소화된 식물성 오일, 류신, 글리세리드 및 스테아릴 푸마르산나트륨,

c) 붕해제, 예컨대 전분, 크로스카멜로스, 소듐 메틸 셀룰로스, 한천, 벤토나이트, 알긴산, 카복시메틸 셀룰로스, 폴리비닐 피롤리돈 등.

다른 적합한 부형제는 미극 약제학 협회에 의해 발행된 문헌[Handbook of Pharmaceutical Excipients]에서 찾을 수 있다.

본 발명에 따른 특정 양의 약제는 질병의 치료 또는 예방에 바람직하다. 그러나, 질병의 중증도, 질병의 유형뿐만 아니라, 치료될 각각의 환자, 예를 들어 환자의 일반적인 건강 상태 등에 따라, 치료 또는 예방 효과를 유도하기 위해 본 발명에 따른 약제의 상이한 투여량이 필요하다는 것을 이해한다. 적절한 투여량의 결정은 주치의의 재량에 의한다. 본 발명에 따른 약제가 예방적으로 사용될 경우, 이는 백신으로서 제형화될 수 있다. 이 경우, 본 발명에 따른 약제는 바람직하게는 상기에 요약된 바람직한 및 특히 바람직한 투여량으로 투여된다. 바람직하게는, 백신의 투여는 각각의 질병의 발병 위험이 감소하도록 하기 위해, 백신화 대상체가 본 발명에 따른 약제에 대해 충분한 항체를 생성할 때까지 소정의 기간 동안 적어도 2, 3, 4, 5, 6, 7, 8, 9 또는 적어도 10회 반복된다. 이 경우의 기간은 일반적으로 백신의 항원성에 따라 변동된다. 바람직하게는 기간은 4주, 3개월, 6개월 또는 3년 이하이다. 일 실시형태에서, 본 발명에 따른 아데노바이러스가 백신화 목적으로 사용되는 경우, 헥손 단백질의 초가변 도메인 중 적어도 하나는 백신화가 유도되는 각각의 질병 제제의 면역원성 에피토프로 대체될 수 있다. 백신은 통상적으로 상기 요약된 하나 이상의 애주번트를 포함한다. 백신화를 위한 아데노바이러스의 사용 및 이에 관한 방법에 대한 상세한 요약은 문헌[Bangari DS and Mittal SK (2006) Vaccine, 24(7), p. 849-862]에 제공되고; 또한: 문헌[Zhou D, et al., Expert Opin Biol Ther. 2006 Jan;6(1):63-72; 및 Folgori A, et al., Nat Med. 2006 Feb;12(2):190-7.]을 참조하며; 또한: 문헌[Draper SJ, et al., Nat Med. 2008 Aug;14(8):819-21. Epub 2008 Jul 27을 참조한다.

제10 양상에서, 본 발명은

(i) 세포에서 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드를 발현시켜, 아데노바이러스 또는 아데노바이러스-유사 입자가 세포내에서 조립되는 단계; 및

(ii) 세포 또는 세포 주위의 배지로부터 아데노바이러스 또는 아데노바이러스-유사 입자를 단리하는 단계를 포함하는, 아데노바이러스 또는 아데노바이러스-유사 입자를 생성하는 시험관내 방법에 관한 것이다.

본 방법은 선택적으로 예를 들어 상기에 기재된 바와 같이, 세포내로 제1 또는 제2 양상의 단리된 폴리뉴클레오타이드 또는 제6 양상의 벡터를 도입시키는 단계 (i) 전에 추가의 단계를 포함한다.

일반적으로 단리된 폴리뉴클레오타이드는 제4 양상의 아데노바이러스 또는 제5 양상의 바이러스-유사 입자를 인코딩하는 것이 바람직하다. 아데노바이러스는 바람직하게는 복제-불능이다. 세포는 바람직하게는 제7 양상의 세포이다. 단리된 폴리뉴클레오타이드가 복제-불능 아데노바이러스를 인코딩하는 경우, 세포는 본 명세서에 기재된 바와 같은 보조 세포이거나, 보조 작제물 (예를 들어, 단계 (i) 전 또는 그 동안 보조 작제물에 의해 형질도입된, 예를 들어 보조 작제물에 의해 감염된 보조 플라스미드 또는 보조 바이러스)을 포함하는 것이 바람직하며, 보조 세포 또는 보조 작제물은 각각 아데노바이러스가 복제-불능이 되는 유전자/게놈 영역을 발현한다.

"아데노바이러스 또는 아데노바이러스 유사 입자가 세포 내에서 조립된다"는 단계 (i)에서, 본 명세서에 기재된 바와 같이 아데노바이러스 또는 아데노바이러스 유사 입자를 조립하는데 필요한 모든 유전자가 세포 내에서 발현된다는 것을 의미한다. 이는 아데노바이러스가 조립되는 경우 아데노바이러스를 패키징하는데 (즉, 게놈을 바이러스 캡시드로 패키징하는데) 필요한 모든 유전자를 포함한다.

바람직한 실시형태에서, 단리된 폴리뉴클레오타이드는 상기에 규정된 바와 같은 VA RNA II 비코딩 RNA 및/또는 VA RNA I 비코딩 RNA를 인코딩한다. 본 발명에 따른 VA RNA는 실시예 1에 도시된 바와 같은 방법의 개선된 아데노바이러스 또는 아데노바이러스 유사 입자 수율을 야기한다.

본 발명의 정의 및 추가의 실시형태

하기에서, 본 명세서에서 빈번하게 사용되는 용어의 일부 정의가 제공된다. 이들 용어는, 명세서의 나머지 부분에서 사용되는 각 경우에, 각각 규정된 의미 및 바람직한 의미를 가질 것이다.

본 명세서에 사용되는 바와 같이, 용어 "단리된"은 자연적으로 관련된 다른 분자가 실질적으로 부재하는 분자를 지칭한다. 특히, 단리된 것은 분자가 동물 신체 또는 동물 신체 샘플에 존재하지 않음을 의미한다. 따라서 단리된 분자에는 동물에서 연관되거나 접촉되는 다른 분자가 부재한다. 단리된 것은 본 명세서에 기재된 바와 같이 관련된 다른 성분으로부터 단리된 것을 의미하지 않으며, 예를 들어 이것이 포함된 세포 또는 벡터로부터 단리되거나, 포함된 분자가 조성물의 다른 성분으로부터 단리된 것을 의미하지 않는다.

용어 "폴리뉴클레오타이드"는 핵산, 즉 복수의 뉴클레오타이드로 구성된 생물학적 분자를 지칭하는 것으로 의도된다. 여기에는 DNA, RNA 및 합성 유사체, 예를 들어 PNA가 포함된다. DNA가 바람직하다.

용어 "오픈 리딩 프레임" (ORF)은 아미노산으로 번역될 수 있는 뉴클레오타이드 서열을 지칭한다. 일반적으로, ORF는 개시 코돈을 포함하며, 후속 영역이 일반적으로 다수의 3개의 뉴클레오타이드 길이를 갖지만, 소정의 리딩 프레임에 종결 코돈 (TAG, TAA, TGA, UAG, UAA 또는 UGA)을 포함하지 않는다. ORF는 번역될 수 있는 아미노산이 펩타이드 연결 사슬을 형성하는 단백질을 코딩한다.

본 명세서에 사용되는 바와 같이, 용어 "단백질", "펩타이드", "폴리펩타이드", "펩타이드들" 및 "폴리펩타이드들"은 전반에 걸쳐 상호 혼용된다. 이러한 용어는 천연 발생 펩타이드, 예를 들어 천연 발생 단백질 및 천연 또는 비 천연 발생 아미노산을 포함할 수 있는 합성 펩타이드 둘 모두를 지칭한다. 펩타이드는 또한 천연 또는 비 천연 발생 아미노산의 측쇄 또는 유리 아미노 또는 카복시-말단을 변형시킴으로써 화학적으로 변형될 수 있다. 이러한 화학적 변형은 글리코실화와 같은 아미노산의 측쇄에서 작용기의 변형뿐만 아니라, 추가의 화학적 모이어티의 첨가를 포함한다. 펩타이드는 바람직하게는 적어도 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95개 또는 적어도 100개의 아미노산, 가장 바람직하게는 적어도 8 또는 적어도 30개의 아미노산을 갖는 중합체이다. 본 명세서에 개시된 폴리펩타이드 및 단백질은 아데노바이러스로부터 유래되므로, 본 명세서에 사용되는 바와 같은 단리된 폴리펩타이드 또는 단백질의 분자량은 200 kDa를 초과하지 않는 것이 바람직하다.

아데노바이러스 (Ad)는 수종의 조류 및 포유류 숙주에서 확인된 무외피의 정이십면체형 바이러스이다. 인간 아데노바이러스 (hAd)는 공지된 모든 인간 및 동물 (예를 들어, 소, 돼지, 개, 쥐, 말, 유인원 및 양) 유래의 다수의 Ad를 포함하는 마스타데노바이러스 (Mastadenovirus) 속에 속한다. 인간 아데노바이러스는 일반적으로 랫트 및 붉은털 원숭이 적혈구의 적혈구 응집 특성, DNA 상동성, 제한효소 절단 패턴, G+C 함량 백분율 및 발암성을 포함하는 다수의 생물학적, 화학적, 면역학적 및 구조적 기준에 따라 6개의 하위그룹 (A 내지 F)으로 분류된다 (문헌[Straus, 1984, in The Adenoviruses, ed. H. Ginsberg, pps.451-498, New York: Plenus Press, and Horwitz, 1990; in Virology, eds. B. N. Fields and D. M. Knipe, pps. 1679-1721]).

아데노바이러스 비리온은 정이십면체 대칭을 가지며, 혈청형에 따라 직경이 60 내지 90 nm이다. 정이십면체 캡시드는 3개의 주요 단백질, 헥손 (II), 펜톤 염기 (III) 및 노브형 섬유 (knobbed fiber) (IV) 단백질을 포함한다 (문헌[W. C. Russel, J. Gen.Virol., 81: 2573-2604 (2000)]). 더욱 구체적으로, 아데노바이러스 캡시드는 252개의 캡소머를 포함하며, 이중 240개는 헥손이고, 12개는 펜톤이다. 헥손 및 펜톤은 3개의 상이한 바이러스 폴리펩타이드로부터 유래된다. 헥손은 3개의 동일한 폴리펩타이드, 즉 폴리펩타이드 II를 포함한다. 펜톤은 캡시드에 대한 부착 지점을 제공하는 펜톤 염기, 및 펜톤 염기에 비공유적으로 결합되고 돌출된 삼량체 섬유 단백질을 포함한다. 다른 단백질, 즉 단백질 IX, VI 및 IIIa도 일반적으로 아데노바이러스 캡시드에 존재한다. 이들 단백질은 바이러스 캡시드를 안정화시키는 것으로 여겨진다.

인간에서 관찰되는 기 존재하는 면역의 한 양상은 체액성 면역이며, 이는 아데노바이러스 단백질에 특이적인 항체의 생성 및 지속성을 야기할 수 있다. 아데노바이러스에 의해 유발된 체액성 반응은 주로 구조 단백질 헥손의 초가변 영역에 대해 유도된다. 비인간 대형 유인원으로부터 단리된 아데노바이러스는 인간 유래의 세포에서 그의 효율적인 증식에 의해 입증된 바와 같이 인간으로부터 단리된 아데노바이러스와 밀접하게 연관된다.

캡시드는 T- 및/또는 B 세포 에피토프와 같은 비-아데노바이러스 폴리펩타이드를 혼입시킴으로써 본 명세서에 기재된 바와 같이 변형될 수 있다.

용어 "헥손 단백질"은 아데노바이러스에 포함된 헥손 (II) 단백질을 지칭한다. 본 발명에 따른 헥손 단백질 또는 그의 변이체는 감염성 아데노바이러스 비리온에서 헥손 단백질 또는 그의 단편과 동일한 기능을 한다. 따라서, 바람직하게는 캡시드 단백질로서 상기 헥손 또는 그의 변이체를 포함하는 아데노바이러스는 숙주 세포에 유입될 수 있다. 헥손 단백질의 변이체를 생성하기 위한 적합한 방법은 미국 특허 제 5,922,315호에 기재되어 있다. 이 방법에서, 아데노바이러스 헥손의 적어도 하나의 루프 영역을 다른 아데노바이러스 혈청형의 적어도 하나의 루프 영역으로 변경시킨다. 재조합 아데노바이러스가 숙주 세포에 유입될 수 있는지는 용이하게 결정될 수 있다. 예를 들어, 숙주 세포를 아데노바이러스와 접촉시킨 후, 재조합 숙주 세포를 세척하고, 용해시킬 수 있으며, 예를 들어 아데노바이러스 RNA 및/또는 DNA에 특이적인 적절한 혼성화 프로브를 사용하여, 아데노바이러스 RNA 및/또는 DNA가 숙주 세포에서 존재하는지를 결정할 수 있다. 대안적으로 또는 추가로, 재조합 아데노바이러스와 접촉된 후 숙주 세포를 세척하고, 용해시키고, 예를 들어 웨스턴 블롯을 사용하여, 아데노바이러스 특이적 항체에 의해 프로빙할 수 있다. 또 다른 대안에서, 숙주 세포에서 유전자 산물을 발현시키기에 적합한 발현 카세트를 포함하는 재조합 아데노바이러스로 감염시 숙주 세포가 유전자 산물, 예를 들어 형광 단백질을 발현하는지를 예를 들어 생체내에서 관찰한다.

용어 "초가변 영역"은 헥손 단백질의 용매-노출된 표면에 위치하여 바이러스 캡시드의 외부에 노출된 것으로, 균주 사이에 서열 변화가 큰 도메인을 지칭한다. 이는 중화 항체의 주요 결정 인자이다. HVR은 예를 들어 다른 헥손 단백질과의 서열 정렬에 의해 확인될 수 있다.

"아데노바이러스 펜톤 단백질"은 아데노바이러스에 포함된 펜톤 염기 (III) 단백질을 의미한다. 아데노바이러스 펜톤 단백질은 이것이 캡시드의 정이십면체 대칭의 모서리에 위치하는 것을 특징으로 한다. 본 발명에 따른 펜톤 단백질 또는 그의 변이체는 감염성 아데노바이러스 비리온에서 펜톤 단백질과 동일한 기능을 한다. 따라서, 바람직하게는 캡시드 단백질로서 상기 펜톤 또는 그의 변이체를 포함하는 아데노바이러스는 숙주 세포에 유입될 수 있으며, 이는 상기 기재된 바와 같이 시험될 수 있다. 또한, 기능성 펜톤은 아데노바이러스 섬유 단백질에 친화도를 갖는다. 당업자는 단백질-단백질 친화도를 시험하는 방법을 잘 알고 있다. 제1 단백질이 제2 단백질에 결합할 수 있는지를 결정하기 위해, 예를 들어, 유전자 효모 2-하이브리드 분석 또는 생화학적 분석, 예컨대 풀다운 (pull-down), 효소-결합 면역흡착 분석 (ELISA), 형광-활성화 세포 분류 (FACS) 기반 분석 또는 플라스몬 공명 분석이 사용될 수 있다. 풀다운 또는 플라스몬 공명 분석이 사용되는 경우, 생화학 분야에 널리 공지된 바와 같이, HIS-태그, GST-태그 또는 다른 친화도 태그에 적어도 하나의 단백질을 융합시키는 것이 유용하다.

용어 "섬유 단백질"은 아데노바이러스에 포함된 노브형 섬유 (IV) 단백질을 지칭한다. 본 발명에 따른 섬유 단백질 또는 그의 변이체는 감염성 아데노바이러스 비리온에서 섬유 단백질 또는 그의 단편과 동일한 기능을 한다. 따라서, 바람직하게는 캡시드 단백질로서 상기 섬유 또는 섬유 변이체를 포함하는 아데노바이러스는 숙주 세포에 유입될 수 있으며, 이는 상기 기재된 바와 같이 시험될 수 있다. 또한, 기능성 섬유 단백질은 아데노바이러스 펜톤 단백질에 친화도를 갖는다. 또한, 글리코실화된 형태의 기능성 아데노바이러스 섬유 단백질은 삼량화할 수 있다. 따라서, 변이체가 글리코실화되고/거나 삼량체를 형성할 수 있는 것이 또한 바람직하다. 삼량체화를 포함한 친화도는 상기 기재된 바와 같이 시험될 수 있으며, 글리코실화 분석은 또한 당 업계에 널리 공지되어 있다.

"VA (바이러스 연관) RNA"는 아데노바이러스에 존재하는 비코딩 유형이다. 이는 번역을 조절하는 역할을 한다. 이 RNA에는 VAI 또는 VA RNA I 및 VAII 또는 VA RNA II라는 2개의 카피가 있다. 2개의 VA RNA 유전자는 아데노바이러스 게놈에서 별개의 유전자이다. VA RNA I이 주요 종이며, VA RN AII는 더 낮은 수준으로 발현된다. 전사체는 폴리아데닐화되지 않으며, 둘 모두 PolIII에 의해 전사된다.

폴리뉴클레오타이드, 폴리펩타이드 또는 단백질 서열과 관련하여 용어 "동일성" 또는 "동일한"은 최대 대응성을 위해 정렬될 때 동일한 두 서열의 잔기의 수를 지칭한다. 구체적으로, 핵산 또는 아미노산 서열에 관계없이, 2개의 서열의 서열 동일성 백분율은 정렬된 2개의 서열 사이의 정확한 매칭 수를 더 짧은 서열의 길이로 나눈 후 100을 곱한 것이다. 2개의 서열을 정렬하는데 사용될 수 있는 정렬 툴은 당업자에게 널리 공지되어 있고, 예를 들어 월드 와이드 웹, 예를 들어 폴리펩타이드 정렬의 경우 Clustal Omega (http://www.ebi.ac.uk/Tools/msa/clustalo/) 또는 폴리뉴클레오타이드 정렬의 경우 MUSCLE (http://www.ebi.ac.uk/Tools/msa/muscle/) 또는 MAFFT (http://www.ebi.ac.uk/Tools/msa/ mafft/) 또는 폴리뉴클레오타이드 및 폴리펩타이드 정렬의 경우 WATER (http://www.ebi.ac.uk/Tools/psa/ emboss_water/)에서 입수할 수 있다. 2개의 서열 사이의 정렬은, 예를 들어 MAFFT의 경우 바람직하게는: Matrix: Blosum62, Gap Open 1.53, Gap Extend 0.123, WATER 폴리뉴클레오타이드의 경우 바람직하게는: MATRIX: DNAFULL, Gap Open: 10.0, Gap Extend 0.5 및 WATER 폴리펩타이드의 경우 바람직하게는 MATRIX: BLOSUM62, Gap Open: 10.0, Gap Extend: 0.5의 디폴트 매개변수 설정을 사용하여 수행할 수 있다. 당업자는 만족스러운 정렬을 생성하기 위해 임의의 순서로 갭을 도입할 필요가 있을 수 있음을 이해한다. "최적의 서열 정렬"은 갭의 수가 가장 적고, 정렬된 잔기 중 동일한 것의 수가 가장 많은 경우의 정렬로 규정된다. 바람직하게는, 이는 정렬 내의 모든 서열의 모든 잔기를 포함하는 전체 정렬이다.

용어 "변이체"는 폴리펩타이드와 관련하여 일반적으로, 폴리펩타이드의 하나 이상의 아미노산이 결실, 삽입, 변형 및/또는 치환될 수 있는 폴리펩타이드의 변형된 형태, 예를 들어 돌연변이를 지칭한다. 일반적으로, 변이체는 기능적이며, 이는 기능적 변이체를 포함하는 아데노바이러스가 숙주 세포를 감염시킬 수 있음을 의미한다. 더욱 구체적인 기능이 본 명세서에 규정되어 있으며, 일반 정의보다 우선한다. "돌연변이" 또는 "아미노산 돌연변이"는 아미노산 치환, 결실 및/또는 삽입일 수 있다 ("그리고" 하나 이상의 돌연변이가 존재하는 경우 적용될 수 있음). 바람직하게는 이는 치환 (즉, 보존적 또는 비 보존적 아미노산 치환), 더욱 바람직하게는 보존적 아미노산 치환이다. 일부 실시형태에서, 치환은 또한 천연 발생 아미노산과 비 천연 발생 아미노산의 교체를 포함한다. 보존적 치환은 하나의 아미노산이, 치환된 아미노산과 유사한 화학적 특성을 갖는 다른 아미노산으로 치환된 것을 포함한다. 바람직하게는, 보존적 치환은 다음으로 이루어진 군으로부터 선택되는 치환이다:

(i) 염기성 아미노산의 또 다른 상이한 염기성 아미노산으로의 치환;

(ii) 산성 아미노산의 또 다른 상이한 산성 아미노산으로의 치환;

(iii) 방향족 아미노산의 또 다른 상이한 방향족 아미노산으로의 치환;

(iv) 비극성 지방족 아미노산의 또 다른 상이한 비극성 지방족 아미노산으로의 치환; 및

(v) 극성 비하전 아미노산의 또 다른 상이한 극성 비하전 아미노산으로의 치환.

염기성 아미노산은 바람직하게는 아르기닌, 히스티딘 및 리신으로 이루어진 군으로부터 선택된다. 산성 아미노산은 바람직하게는 아스파테이트 또는 글루타메이트이다. 방향족 아미노산은 바람직하게는 페닐알라닌, 티로신 및 트립토판으로 이루어진 군으로부터 선택된다. 비 극성 지방족 아미노산은 바람직하게는 글리신, 알라닌, 발린, 류신, 메티오닌 및 이소류신으로 이루어진 군으로부터 선택된다. 비하전된 극성 아미노산은 바람직하게는 세린, 트레오닌, 시스테인, 프롤린, 아스파라긴 및 글루타민으로 이루어진 군으로부터 선택된다. 보존적 아미노산 치환과 달리, 비 보존적 아미노산 치환은 상기에 요약된 보존적 치환 (i) 내지 (v)가 아닌 하나의 아미노산에서 임의의 아미노산으로의 교체이다.

서열 동일성을 결정하기 위한 수단은 상기에 기재되어 있다.

단백질의 아미노산은 또한 변형, 예를 들어 화학적으로 변형될 수 있다. 예를 들어, 단백질 또는 폴리펩타이드의 아미노산의 측쇄 또는 유리 아미노 또는 카복시-말단은 예를 들어 글리코실화, 아미드화, 인산화, 유비퀴틴화 등에 의해 변형될 수 있다. 화학적 변형은 생체내, 예를 들어 숙주 세포 내에서 이루어질 수 있으며, 이는 당 업계에 널리 공지된 바와 같다. 예를 들어, 단백질의 아미노산 서열에 존재하는 적절한 화학적 변형 모티프, 예를 들어 글리코실화 서열 모티프는 단백질의 글리코실화를 유발할 것이다. 변형이 변형된 아미노산의 동일성을 변화시키지 않으면 (예를 들어, 치환 또는 결실), 변형된 폴리펩타이드는 특정 서열번호와 관련하여 언급된 바와 같이 폴리펩타이드의 범위 내에 있으며, 즉 이는 본 명세서에 규정된 바와 같은 변이체가 아니다.

용어 "변이체"는 폴리뉴클레오타이드와 관련하여, 일반적으로, 폴리뉴클레오타이드의 하나 이상의 뉴클레오타이드가 결실, 삽입, 변형 및/또는 치환될 수 있는 폴리뉴클레오타이드의 변형된 형태, 예를 들어 돌연변이를 지칭한다. 일반적으로, 변이체는 기능적이며, 이는 기능적 변이체를 포함하는 아데노바이러스가 숙주 세포를 감염시킬 수 있음을 의미한다. 더욱 구체적인 기능이 본원에 규정되어 있으며, 일반 정의보다 우선한다. "돌연변이"는 뉴클레오타이드의 치환, 결실 및/또는 삽입일 수 있다 ("그리고" 하나 이상의 돌연변이가 존재하는 경우 적용될 수 있음). 바람직하게는 이는 치환이며, 더욱 바람직하게는 이는 아미노산 치환, 가장 바람직하게는 보존적 아미노산 치환을 야기한다.

"항원성 단백질 또는 그의 단편" (단편은 또한 항원성임)은 포유류에서 면역 반응을 유발할 수 있다. 바람직하게는 이는 종양 항원 또는 병원체 유래의 항원이다. 용어 "병원체"는 대상체에서 질병을 유발할 수 있는 임의의 유기체를 지칭한다. 이는 다음에 제한되는 것은 아니나, 박테리아, 원생동물, 진균, 선충, 비로이드, 바이러스 및 기생충을 포함 하며, 각 병원체는 자체적으로 또는 다른 병원체와 함께, 다음에 제한되는 것은 아니나 포유류를 포함하고, 다음에 제한되는 것은 아니나 인간을 포함하는 척추동물에서 질병을 유발할 수 있다. 본 명세서에 사용되는 바와 같이, 용어 "병원체"는 또한 일반적으로 비 면역 손상 숙주에서 병원성일 수 없지만, 면역 손상 숙주에서는 병원성인 유기체를 포함한다.

일반적으로 말하면, 아데노바이러스 게놈은 잘 특성화되어 있다. 아데노바이러스 게놈의 전체 체계에서, 특정 오픈 리딩 프레임이 유사하게 위치하는 것과 관련하여, 예를 들어 각 바이러스의 E1A, E1B, E2A, E2B, E3, E4, LI, L2, L3, L4 및 L5 유전자의 위치가 일반적으로 보존된다. 아데노바이러스 게놈의 각 말단은 바이러스 복제에 필요한 역위 말단 반복 (ITR)으로 공지된 서열을 포함한다. 바이러스는 또한 바이러스 인코딩 프로테아제를 포함하는데, 이는 감염성 비리온을 생성하는데 필요한 일부 구조 단백질을 처리하는데 필요하다. 아데노바이러스 게놈의 구조는 숙주 세포 형질도입 후에 바이러스 유전자가 발현되는 순서를 기반으로 하여 기재된다. 더욱 구체적으로, 바이러스 유전자는 전사가 DNA 복제의 개시 이전 또는 이후에 발생하는지에 따라 초기 (E) 또는 후기 (L) 유전자로 지칭된다. 형질도입의 초기 단계에서, 바이러스 복제를 위해 숙주 세포를 제조하기 위해, 아데노바이러스의 E1A, E1B, E2A, E2B, E3 및 E4 유전자가 발현된다. 감염의 후기 단계 동안, 바이러스 입자의 구조적 성분을 인코딩하는 후기 유전자 L1-L5의 발현이 활성화된다.

본 명세서에 사용되는 바와 같이, 용어 "벡터"는 플라스미드 벡터, 코스미드 벡터, 파지 벡터 예컨대, 람다 파지, 바이러스 벡터 예컨대, 아데노바이러스 (Ad) 벡터 (예를 들어, 당 업계, 예를 들어 WO 2005/071093 A2에 공지되어 있는 비 복제 Ad5, Ad11, Ad26, Ad35, Ad49, ChAd3, ChAd4, ChAd5, ChAd7, ChAd8, ChAd9, ChAd10, ChAd11, ChAd16, ChAd17, ChAd19, ChAd20, ChAd22, ChAd24, ChAd26, ChAd30, ChAd31, ChAd37, ChAd38, ChAd44, ChAd63 및 ChAd82 벡터 또는 복제 가능 Ad4 및 Ad7 벡터), 아데노-연관 바이러스 (AAV) 벡터 (예를 들어, AAV 5형), 알파바이러스 벡터 (예를 들어, 베네수엘라 말 뇌염 바이러스 (VEE), 신드비스열 바이러스 (SIN), 셈리키삼림열바이러스 (semliki forest virus) (SFV) 및 VEE-SIN 키메라), 헤르페스 바이러스 벡터, 홍역 바이러스 벡터, 폭스 바이러스 벡터 (예를 들어, 백시니아 바이러스, 변형된 백시니아 바이러스 앙카라 (MVA), NYVAC (백시니아 코펜하겐 균주로부터 유래) 및 조류폭스 (avipox) 벡터: 카나리폭스 (canarypox) (ALVAC) 및 계두 (FPV) 벡터), 및 수포성 구내염 바이러스 벡터, 바이러스성 입자 또는 박테리아 포자를 포함하여, 당업자에 공지된 임의의 벡터를 포함한다. 벡터는 또한 발현 벡터, 클로닝 벡터 및 숙주 세포에서 재조합 아데노 바이러스를 생성하는데 유용한 벡터를 포함한다.

상기 언급된 바와 같이, "이종성 단백질 또는 그의 단편"은 비-아데노바이러스 단백질 또는 그의 단편, 특히 항원성 단백질 또는 그의 단편일 수 있다. 이를 위해, 이종성 단백질을 인코딩하는 폴리뉴클레오타이드는 예를 들어 표적 세포로 전달될 분자, 예를 들어 항원성 단백질 또는 그의 단편, 바람직하게는 병원성 바이러스, 박테리아, 진균, 원생동물 또는 기생충과 같은 병원체 또는 종양 항원의 항원성 단백질 또는 그의 단편을 인코딩하는 폴리뉴클레오타이드일 수 있다. "항원"은 포유류에서 면역 반응을 유발할 수 있는 임의의 단백질 또는 펩타이드를 지칭한다. 항원은 바람직하게는 적어도 8개의 아미노산을 포함하고, 가장 바람직하게는 8 내지 12개의 아미노산을 포함한다.

용어 "발현 카세트"는 그의 전사 및 번역 제어 서열과 함께 발현될 적어도 하나의 핵산 서열을 포함하는 핵산 분자를 지칭한다. 발현 카세트를 변화시키면, 이를 포함하는 벡터가 상이한 서열 또는 서열 조합의 발현을 유도하게 할 것이다. 제한 부위는 5' 및 3' a말단에 존재하도록 조작되어 있기 때문에, 카세트를 용이하게 삽입되거나, 제거되거나, 다른 카세트로 교체될 수 있다. 바람직하게는, 발현 카세트는 소정의 유전자, 예컨대 프로모터, 개시 부위 및/또는 폴리아데닐화 부위의 효율적인 발현을 위한 시스형 (cis) 조절 요소를 포함한다. 본 발명과 관련하여 더욱 구체적으로, 발현 카세트는 숙주 세포에서 제1 또는 제2 양상의 폴리뉴클레오타이드의 발현에 필요한 모든 추가 요소를 포함한다. 따라서, 통상적인 발현 카세트는 제1 또는 제2 양상의 폴리뉴클레오타이드에 작동 가능하게 연결된 프로모터 및 전사체의 효율적인 폴리아데닐화에 필요한 신호, 리보솜 결합 부위 및 번역 종결 인자를 포함한다. 카세트의 추가 요소는 예를 들어 인핸서를 포함할 수 있다. 발현 카세트는 또한 효율적인 종결을 제공하기 위해 구조 유전자의 하류에 전사 종결 영역을 포함해야 한다. 종결 영역은 프로모터 서열과 동일한 유전자로부터 획득될 수 있거나, 상이한 유전자로부터 획득될 수 있다.

본 명세서에 사용되는 바와 같이, 용어 "미니유전자"는 천연 발생 유전자와 비교하여 유전자의 하나 이상의 기능적으로 비 필수적인 절편이 결실된 이종성 유전자 작제물을 지칭한다. "미니유전자 카세트"는 발현을 위한 미니유전자를 포함하는 발현 카세트이다.

용어 "복제-가능" 재조합 아데노바이러스 (AdV)는 세포에 포함된 임의의 재조합 보조 단백질의 부재 하에 숙주 세포에서 복제될 수 있는 아데노바이러스를 지칭한다. 바람직하게는, "복제-가능" 아데노바이러스는 다음과 같은 온전한 또는 기능적 필수 초기 유전자: E1A, E1B, E2A, E2B, E3 및 E4를 포함한다. 특정 동물로부터 단리된 야생형 아데노바이러스는 해당 동물에서 복제 가능할 것이다.

용어 "복제-결함" 또는 "복제-불능" 재조합 AdV는 적어도 기능적 결실, 즉, 그 전체가 제거되지 않은 상태에서 유전자의 기능을 손상시키는 결실, 예를 들어 인위적 종결 코돈의 도입, 활성 부위 또는 상호작용 도메인의 결실 또는 돌연변이, 유전자의 조절 서열의 돌연변이 또는 결실 등 또는 E1, E2, E3 및 E4로부터 선택되는 하나 이상의 아데노바이러스 유전자와 같이, 바이러스 복제에 필수적인 유전자 산물을 인코딩하는 유전자의 완전한 제거를 포함하도록 조작되어, 복제가 불가능하게 된 아데노바이러스를 지칭한다. 본 발명의 재조합 아데노바이러스 바이러스는 바람직하게는 복제 결함이다.

용어 "재조합 아데노바이러스"는 특히, 이종성 폴리뉴클레오타이드 및/또는 폴리펩타이드 서열을 포함하도록 변형된 아데노바이러스를 지칭한다. "이종성"은 다른 아데노바이러스 균주, 특히 상이한 숙주 (예를 들어, 인간 숙주, 따라서 인간 아데노바이러스, 예컨대 Ad3 또는 Ad5), 또는 비-아데노바이러스 유기체, 예컨대 본 명세서에 기재된 바와 같은 병원체, 또는 인간 종양 항원과 같은 인간으로부터의 균주를 의미할 수 있다. 이와 같이, 본 용어는 각각 키메라 및 전달체 아데노바이러스를 포함한다. 재조합 아데노바이러스는 다른 아데노바이러스 또는 비-아데노바이러스 유기체로부터의 이종성 폴리뉴클레오타이드 및/또는 폴리펩타이드 서열을 포함할 수 있으며, 즉 이는 키메라 및 전달체 아데노바이러스 둘 모두일 수 있다.

본 명세서에 사용되는 바와 같이, 용어 "바이러스-유사 입자" 또는 "VLP"는 이 경우 아데노바이러스로부터 유래된 비어 있는 비 복제 바이러스 껍질을 지칭한다. VLP는 일반적으로 다음에 제한되는 것은 아니나, 캡시드, 코팅, 껍질, 표면 및/또는 외피 단백질로 지칭되는 단백질과 같은 하나 이상의 바이러스 단백질로 구성된다. 이는 바이러스에 의한 세포 침투에 관여하는 기능성 바이러스 단백질을 포함하고 있어, 효율적인 세포 유입을 가능하게 한다. VLP는 적절한 발현 시스템에서 단백질의 재조합 발현시 자발적으로 형성될 수 있다. 특정 VLP를 생성하는 방법은 당 업계에 공지되어 있다. 아데노바이러스 VLP는 특히 기능적 손상, 예를 들어 바이러스 DNA 패킹에 관여하는 아데노바이러스의 Iva2 유전자로의 널 돌연변이의 도입 또는 결실에 의해 생성될 수 있다 (문헌[Ostapchuk et al. J Virol. 2011 Jun; 85(11): 5524-5531]). VLP의 존재는 전자 현미경법, X-선 결정학 등과 같은 당 업계에 공지된 통상적인 기법을 사용하여 검출될 수 있다. 예를 들어, 문헌[Baker et al., Biophys. J. (1991) 60:1445-1456; Hagensee et al., J. Virol. (1994) 68:4503-4505]을 참조한다. 예를 들어, 해당 VLP 제조물의 수성 샘플에 대해 글라스 하에 극저온 전자 현미경법을 수행할 수 있으며, 적절한 노출 조건 하에서 이미지를 기록하였다.

VLP에 포함된 "바이러스 게놈 DNA의 실질적 부재"는 VLP에 바이러스 게놈 DNA가 존재하지 않거나, VLP에 감염된 세포에서 바이러스 복제를 가능하게 하는 VLP 내의 바이러스 DNA가 충분하지 않고, 바이러스 복제가 이루어질 수 있도록 하는 VLP 내의 DNA를 보완하는 DNA를 발현하지 않는 것을 의미한다.

상기에 더하여, 항원 결정 인자로도 언급되는 "에피토프"는 면역 시스템, 구체적으로 항체, B 세포 또는 T 세포에 의해 인식되는 거대 분자의 절편이다. 본 발명과 관련하여, 바람직하게는, 용어 "에피토프"는 면역 시스템에 의해 인식되는 단백질 또는 폴리단백질의 절편을 지칭한다. 에피토프는 일반적으로 아미노산 또는 당 측쇄와 같은 분자의 화학적 활성 표면 기로 구성되며, 일반적으로 특정의 3차원 구조 특성뿐만 아니라, 특정 전하 특성을 갖는다. 입체형태 및 비 입체형태 에피토프는 변성 용매의 존재하에 전자의 경우 결합능이 존재하나, 후자의 경우 결합능을 상실한다는 점에서 구별된다.

"비-아데노바이러스 T 세포 에피토프"는 항원-제시 세포의 표면 상에 제시될 수 있는 에피토프이며, 이는 MHC 분자에 결합한다. 인간에서, 전문 항원-제시 세포는 MHC 클래스 II 펩타이드를 제시하도록 특화되어 있으며, 대부분의 핵 형성 체세포는 MHC 클래스 I 펩타이드를 제시한다. MHC 클래스 I 분자에 의해 제시된 T 세포 에피토프는 통상적으로 8 내지 11개의 아미노산 길이의 펩타이드이며, MHC 클래스 II 분자는 13 내지 17개의 아미노산 길이의 더 긴 펩타이드를 제시한다.

"비-아데노바이러스 B 세포 에피토프"는 B 세포에 의해 고유 항원의 표면 상의 3차원 구조로 인식되는 에피토프이다.

B-세포 및 T-세포 에피토프는 인실리코 툴 (in silico tool), 예를 들어 IEDB 분석 리소스의 온라인 B-세포 및 T-세포 예측 툴로 예측될 수 있다.

용어 "하나 이상의 비-아데노바이러스 B 세포 에피토프를 제시하다"는 하나 이상의 에피토프가 캡시드 내로 혼입되어, B 세포에 의해 인식되도록 하는 것을 의미한다. 용어 "하나 이상의 비-아데노바이러스 B/T 세포 에피토프를 혼입시키다"는 에피토프가 캡시드에 혼입되지 않았거나, 캡시드에 혼입된 상태에서 VLP에 포함됨을 의미한다. 이것이 캡시드에 혼입되어 있는 경우, 이는 면역 세포에 의해 인식될 수 있도록 외부에 제시되거나 제시되지 않을 수 있다.

"면역 애주번트" 또는 간단히 "애주번트"는 항원 단독의 투여와 비교하여, 항원/면역원에 대한 면역 반응의 특질 및/또는 강도를 가속화, 연장 및/또는 향상시킴으로써, 소정의 임의의 백신에 필요한 항원/면역원의 양 및/또는 대상 항원/면역원에 대한 적절한 면역 반응을 생성하기 위해 필요한 주사 횟수를 감소시키는 물질이다. 본 발명에 따른 조성물과 관련하여 사용될 수 있는 애주번트의 예는 수산화알루미늄 (alum)의 겔형 침전물; AlPO₄; 알하이드로겔; 그람 음성 박테리아의 외막으로부터의 박테리아 산물, 특히 모노포스포릴 지질 A (MPLA), 리포다당류 (LPS), 뮤라밀 디펩타이드 (muramyl dipeptide) 및 이들의 유도체; Freund의 불완전 애주번트; 리포좀, 특히 중성 리포좀, 조성물 및 선택적으로 사이토카인을 포함하는 리포좀; 비이온성 블록 공중합체; ISCOMATRIX 애주번트 (문헌[Drane et al., 2007]); CpG 디뉴클레오타이드 (CpG 모티프), 특히 포스포로티오에이트 (PTO) 골격 (CpG PTO ODN) 또는 포스포디에스테르 (PO) 백본 (CpG PO ODN)을 갖는 CpG ODN을 포함하는 비 메틸화 DNA; 합성 리포펩타이드 유도체, 특히 Pam₃Cys; 리포아라비노 만난; 펩티도 글리칸; 자이모산; 열 충격 단백질 (HSP), 특히 HSP 70; dsRNA 및 이들의 합성 유도체, 특히 폴리 I:폴리 C; 다가 양이온성 펩타이드, 특히 폴리-L-아르기닌; 탁솔; 피브로넥틴; 플라겔린; 이미다조퀴놀린; 애주번트 활성을 갖는 사이토카인, 특히 GM-CSF, 인터루킨-(IL-)2, IL-6, IL-7, IL-18, I 및 II형 인터페론, 특히 인터페론-감마, TNF-알파; 25-디하이드록시비타민 D3 (칼시트리올); 및 합성 올리고펩타이드, 특히 MHCII-제시 펩타이드이다. 폴리옥시에틸렌 (POE) 및 폴리옥시프로필렌 (POP)을 포함하는 비이온성 블록 중합체, 예컨대 POE-POP-POE 블록 공중합체가 애주번트로서 사용될 수 있다 (문헌[Newman et al., 1998]). 이러한 유형의 애주번트는 활성 구성성분으로서 핵산을 포함하는 조성물에 특히 유용하다.

본 발명과 관련하여 용어 "백신화"는 활성 면역화, 즉, 적합한 면역원성 제형 중 항원 (외래 물질임에 따라 면역원으로 인식되므로, 면역 시스템이 각각 백신화하는 물질)의 (예를 들어, 피하, 피내, 근육내, 경구, 비강) 투여에 의한 특이적 면역 반응의 유도이다. 따라서, 항원은 면역 시스템이 항원에 대한 특이적 면역 반응을 형성하기 위한 촉발 인자로 사용된다. 본 발명의 범주 내에서 백신화는 원칙적으로 치료적 의미뿐만 아니라, 예방적 의미로 수행될 수 있다. 여기에는 감염성 질병을 치료 또는 예방하기 위한 본 명세서에 기재된 병원체에 대한 백신화, 또는 암과 같은 비 감염성 질병을 치료 또는 예방하기 위한 백신화가 포함된다. 비 감염성 질병의 경우, 항원은 바람직하게는 세포막 항원, 특히 단지 발병 세포에 의해서는 발현되나, 비 발병 세포에 의해서는 발현되지 않는 것이 바람직하다. 예에는 종양 관련 항원이 있다. 이와 관련하여, 용어 "종양 관련 항원"은 주로 종양 세포에 의해 제시됨에 따라, 비 악성 조직으로부터의 분화를 가능하게 하는 구조를 의미한다. 바람직하게는, 이러한 종양 관련 항원은 종양 세포의 세포막 상 또는 그 내부에 위치한다. 종양 관련 항원의 예는 예를 들어 문헌[DeVita et al. (Eds., "Biological Therapy of Cancer", 2. Edition, Chapter 3: Biology of Tumor Antigens, Lippincott Company, ISBN 0-397-51416-6 (1995))]에 기재되어 있다.

본 명세서에 사용되는 바와 같이, "프라이밍(priming)"은 포유류에서 면역 반응을 유도/생성하기 위한 백신의 투여를 지칭하고, "부스팅"은 포유류에서 면역 반응을 향상시키기 위한 백신의 투여를 지칭한다. 어구 "이종성 프라이밍-부스팅"은 포유류에서 면역 반응을 유도/생성하기 위한 백신 (프라이밍) 및 포유류에서 면역 반응을 향상시키기 위한 백신 (부스팅)이 상이하다는 것을 의미한다. 이종성 프라이밍-부스팅은 대상체, 예를 들어 환자가 제1 벡터에 대한 항체를 발생시켰으며, 부스팅이 필요한 경우 유용하다. 이와 관련하여, 제1 백신에 의한 프라이밍 동안 유도되는 항체 반응이, 프라이밍 및 부스팅에 적용되는 동물 세포의 핵으로의 유입으로부터 부스팅을 위해 투여되는 제2 백신 입자의 70% 초과 또는 바람직하게는 80% 초과를 방지하지 않는 경우, 제1 (프라이밍) 및 제2 (부스팅) 백신, 예를 들어 아데노바이러스는 충분히 상이하다.

용어 "유전자 요법"은 환자의 임상 상태를 개선시키기 위한 목적으로 결함 유전자의 교정을 위해 외래 유전 물질을 세포, 조직 또는 기관에 직접 도입하는 개념으로 광범위하게 규정될 수 있다. 본 명세서에 사용되는 바와 같이, 용어 "유전자 요법"은 바람직하게는 "체성 요법"을 지칭하고, 세대에서 세대로 전달되는 유전적 변화를 유도하는 "생식선 요법"을 지칭하지 않으며, 체성 요법은 치료 효과를 치료되는 개체로 국한시킨다. 유전자 요법, 바람직하게는 체성 요법은 유기체로의 빠르고 쉬운 직접 유전자 전달 ("생체 내") 또는 치료 후 재이식되는 외식된 세포 또는 조직으로의 정교하지만 더욱 구체적이고 제어 가능한 유전자 전달 ("생체외" 또는 "시험관내")에 의해 추가로 구별될 수 있다.

용어 "중화 항체"는 아데노바이러스의 에피토프에 결합하여 숙주 세포에서 증식성 감염을 유발하는 것을 방지하거나, 전이유전자를 발현하는 복제 불능 벡터에 의한 표적 세포의 형질도입을 방지하는 항체를 지칭하고, 예를 들어 아데노바이러스 DNA는 세포, 특히 숙주 세포에 유입될 수 있다.

본 발명의 범위를 벗어남이 없이 본 발명의 다양한 수정 및 변형이 당업자에게 자명할 것이다. 본 발명은 바람직한 특정 실시형태와 관련하여 기재되었지만, 청구된 본 발명은 이러한 특정 실시형태에 과도하게 제한되어서는 안된다는 것을 이해해야 한다. 실제로, 당업자에 자명한 것으로, 본 발명을 수행하기 위한 기재된 방식의 다양한 변형이 본 발명에 의해 포함되는 것으로 의도된다.

본 발명은 하기 실시예에 의해 설명되며, 이는 단지 예시적이고, 본 발명의 범위를 제한하지 않는 것으로 해석되어야 한다.

실시예

실시예 1: 신규한 아데노바이러스 벡터의 단리

pGADNOU19 및 pGADNOU20 벡터의 작제를 하기 제공된 단계를 통해 진행하였다. pGADNOU19 및 pGADNOU20 벡터는 표준 절차를 사용하여 건강한 비인간 대형 유인원으로부터 채취한 분변 샘플로부터 단리된 야생형 아데노바이러스 균주로부터 유래하였다. 분변 추출물로 HEK 293 및 A549 세포의 단층을 접종하여 야생형 바이러스를 단리하였다. 세포 단층을 세포 변성 효과의 출현에 대해 매일 관찰하였다. 현미경으로 관찰하여 양의 값의 샘플을 수집한 후, 세포를 동결-해동 (-700℃/37℃)에 의해 용해시켰다. 이어서, 정화된 세포 용해물을 사용하여 바이러스 증식을 위해 단층의 새로운 세포를 감염시켰다. 바이러스 증폭의 2회 계대 후, 표준 절차를 사용하여 아데노바이러스를 정제하였다. 바이러스 게놈을 SDS/프로테아제 K 분해 및 페놀-클로로포름 추출에 의해 정제된 바이러스로부터 추출하였다. 정제된 아데노바이러스 DNA를 셔틀 플라스미드 벡터에 클로닝하여 다음과 같은 바이러스 게놈 결실을 수행함으로써 변형시켰다:

1) 바이러스 게놈의 E1 영역 (bp 461 내지 bp 3402)의 결실

2) 바이러스 게놈의 E3 영역 (bp 28472 내지 bp 31996)의 결실

실시예 2: GADNOU 셔틀 벡터의 생성

GADNOU 바이러스의 정제된 DNA 게놈을 먼저 시퀀싱 (sequencing)한 다음, DNA 서열 정보를 사용하여 상동성 재조합에 의해 GAd의 전체 게놈을 클로닝하기 위한 셔틀 벡터를 작제하였다. E1 영역 결실 (뉴클레오타이드 좌표: 461 내지 3402)을 도입시키기 위해 셔틀 벡터를 설계하였다. 간략하게, GADNOU 바이러스를 클로닝하는데 사용된 셔틀 벡터 (본 명세서에서 pGAd-GAG 셔틀로 지칭됨)를 다음과 같이 작제하였다:

a. EcoRI 및 SfiI로 분해한 올리고뉴클레오타이드 FW 5'-GAACTCCgaattcgtttaaaccatcatcaataatataccttattttggattgaggccaatatgataatgaggtgggcggggcgaggcggggcgggtgacgtagg-3' (서열번호 58) 및 RV 5'-cataatcGGCCGCAGCGGCCCGTCAG ATGACGGCGACAATAAA-3' (서열번호 59)에 의한 PCR에 의해 GAd-GAG 좌측 말단을 증폭시킨 후, EcoRI 및 SfiI로 분해한 pUC19 rc_MCS_좌측 말단_PIX_우측 말단_V1에 결찰시킴으로써, pUC19 L-ITR GAd-GAG를 생성시켰다.

b. PshA1 및 BamHI로 분해한 올리고뉴클레오타이드 FW 5'-Cataatcgacccgagtcgcactctcacagcaccagca-3' (서열번호 60) 및 RV 5'-GAACTCCggatccgtttaaacCATCATCAATAATATACCTTATTTTG-3' (서열번호 61)에 의한 PCR에 의해, GAd 우측 말단을 증폭시킨 후, PshA1 및 BamHI로 분해한 pUC19 L-ITR GAd-GAG에 결찰시킴으로써, pUC19 L/R-ITR GAd-GAG를 생성시켰다.

c. AsisI-AscI로 분해한 올리고뉴클레오타이드 FW 5'-Cataatcgcgatcgcgcttaggcctgaccatctgg-3' (서열번호 62) 및 RV 5'-GAACTCCggcgcgccTTAGGGGGAGGCAAGGCTG-3' (서열번호 63)에 의한 PCR에 의해 pIX 코딩 영역을 포함하는 DNA 단편을 증폭시킨 후, AsisI-AscI로 분해한 플라스미드 pUC19 L/R-ITR GAd-GAG에 클로닝시킴으로써, pUC19 L/R-ITR pIX GAd-GAG를 생성시켰다.

d. MscI-SfiI로 분해한 플라스미드 phCMV-GAG로부터 HCMV-GAG-BGH폴리A 카세트를 획득하였다. MscI-SfiI로 분해한 pUC19 L/R-ITR pIX GAd-GAG에 카세트를 클로닝시킨 후, 평활 말단이 되도록 함으로써, pGAd-GAG 셔틀을 생성시켰다.

e. 플라스미드 영역을 BAC 영역으로 대체함에 의한 셔틀 BAC의 작제: PmeI로 분해한 플라스미드 pBELO BAC RDL로부터 BAC 영역을 획득한 후, PmeI로 분해한 플라스미드 pGAd-GAG 셔틀에 클로닝시킴으로써, BAC GAd-GAG 셔틀을 생성시켰다.

f. 우측 말단 및 pIX 영역 사이에의 Amp-LacZ-SacB 선택 카세트의 삽입: AscI로 분해한 올리고뉴클레오타이드 FW (5'-GAACTCCGGCGCGCCTAGG GATAACAGGGTAAT ACCCCTATTTGTTTATTTTTCT-3', 서열번호 64) 및 RV (5'-CATAATCGGCGCGCCATTACCCTGTTATCCCTATTATTTGTTAACTGTTAA TTGTC-3', 서열번호 65)을 사용한 PCR에 의해 플라스미드 pChAd 셔틀 플라스미드로부터 Amp-LacZ-SacB 선택 카세트를 획득하였다. AscI로 분해한 BAC GAd-GAG 셔틀에 선택 카세트를 클로닝시킴으로써, BAC GAd-GAG A/L/S 셔틀을 생성시켰다 (도 1).

플라스미드 DNA로부터 바이러스 DNA가 방출되도록 하기 위해, 두 ITR의 말단에만 존재하는 제한효소 부위 (PmeI)를 포함하는 셔틀 플라스미드를 설계하였다.

실시예 3: ΔE1 벡터의 작제

GADNOU wt 게놈 DNA를 프로테아제 K 분해 후 페놀/클로로포름 추출에 의해 단리하였다. E. 콜라이 균주 BJ5183에서 상동성 재조합에 의해 pGADNOU19 및 pGADNOU20 벡터를 획득하였다. 정제된 WT 바이러스 DNA 및 BAC GAd-GAG A/L/S 셔틀로 E. 콜라이 균주 BJ5183 세포를 공동-형질전환시킴으로써 바이러스 DNA의 클로닝을 획득하였다. 셔틀 BAC (AscI로 분해함)의 말단에 존재하는 ITR DNA 서열 우측의 pIX 유전자 및 바이러스 게놈 DNA 사이의 상동성 재조합에 의해, 이를 BAC 벡터 내에 삽입하고, 동시에 E1 영역을 결실시키고, 발현 카세트로 치환함으로써, △E1/GAG (BAC) 벡터 GADNOU19 GAG BAC 및 GADNOU20 GAG BAC를 생성시킬 수 있다. 헥손 영역에서의 제한 분석 및 PCR 시퀀싱에 의해 스크리닝을 수행하였다.

실시예 4: △E3 벡터의 작제

작제 전략은 다음에 기재된 바와 같은 2개의 연속 단계를 기반으로 하였다:

a) Amp-LacZ-SacB 선택 카세트에 의한 E3 영역의 치환:

올리고뉴클레오타이드 FW (5'-GGATTACACCAAGATCTTTGCTGTC ATTTGTGTGCTGAGTATAATAAAGGCTGAGATCAGAATCTACTCGACCCCTATTTGTTTATTTTTCT-3', 서열번호 66) 및 RV (5'-CTTGCTATCAGA TTTCAAGTAAGTGATTTTTTATTGATTACAGTTATGATCAATTGAAAGGGATAAGGTCTTATTTGTTAACTGTTAATTGTC-3', 서열번호 67)를 사용하여 PCR에 의해 BAC GAd-GAG A/L/S 셔틀로부터 Amp-LacZ-SacB 선택 카세트를 획득하였다. PCR에 의해 획득된 DNA 단편을 그 후 GAdNou19 GAG BAC 및 GAdNou20 GAG BAC에 클로닝하고, 재조합 조작 기법에 의해 GAdNou19 GAG (DE1E3) A/L/S BAC 및 GAdNou20 GAG (DE1E3) A/L/S BAC를 획득하였다.

b) E3 영역 결실을 위한 Amp-lacZ-SacB 선택 카세트의 결실:

단일 가닥 올리고뉴클레오타이드 (5' ctgtcatttgtgtgctgagtataataaaggctgagatcagaatctactcggaccttatccctttcaattgatcataactgtaatcaataaaaaatcactt-3', 서열번호 68)를 사용하여, Amp-LacZ-SacB 선택 카세트를 결실시키고, Amp-LacZ-SacB 선택 카세트를 ss 올리고로 치환한 후, E3 영역을 결실시켰다. ss 올리고를 사용하여, 재조합 조작 기법에 의해 GADNOU19 GAG (DE1E3) A/L/S BAC 및 GADNOU20 GAG (DE1E3) A/L/S BAC에 선택 카세트를 대체함으로써, 최종 플라스미드 GADNOU19 GAG (DE1E3) BAC (도 2) 및 GADNOU20 GAG (DE1E3) BAC (도 3)를 생성시켰다.

실시예 5: 신규한 아데노바이러스 벡터의 증식성 향상

E1 결실을 보유하고, GAG 항원을 발현하는 2개의 비인간 대형 유인원 아데노바이러스 벡터, GADNOU19 및 GADNOU20의 증식성을 Hek293 부착성 세포에서 평가하였다. 동일한 발현 카세트를 보유하는 벤치마크 Ad5 벡터와 비교하여, MOI 100 및 MOI 300 vp/세포에서 정제된 바이러스로 T25 부착성 세포를 감염시켜 증식성을 평가하였다. 감염된 세포를 전체 세포 변성 효과가 명백한 감염 후 3일째에 수확하고; 3회 사이클의 동결/해동 (-70℃/37℃)에 의해 감염된 세포로부터 바이러스를 방출시키고, 이어서 용해물을 원심분리에 의해 정화시켰다. CMV 프로모터 영역에 상보적인 프로브 및 프라이머에 의한 정량적 PCR에 의해 정화된 용해물을 정량화하였다. 올리고 뉴클레오타이드 서열은 다음과 같다: CMVfw 5'-CATCTACGTATTAGTCATCGCTATTACCA-3' (서열번호 69), CMVrv 5'-GACTTGGAAATCCCCGTGAGT-3' (서열번호 70), CMVFAM-TAMRA 프로브 5'-ACATCAATGGGCGTGGATAGCGGTT-3' (서열번호 71). ABI Prism 7900 서열 검출기 - Applied Biosystem에서 QPCR을 구동시켰다. GAG를 발현하는 GADNOU 및 GADNOU19의 세포당 바이러스 입자 (vp/세포)에서 나타난 결과적인 특정 증식성은 동일한 발현 카세트를 보유하는 벤치마크 Ad5 벡터보다 유의하게 더 높았다 (도 1).

증식성 향상의 이론적 근거: 본 발명의 아데노바이러스 게놈은 면역 역가가 높은 것으로 공지된 아데노바이러스 그룹 C에 속한다. 동시에, 그룹 C 바이러스는 상대적으로 저조한 증식성을 특징으로 한다. 본 발명자들은 본 발명의 아데노바이러스 게놈이 많은 다른 그룹 C 아데노바이러스와 상이한 특정 게놈 특징을 포함한다는 것을 발견하였다. 이 특징은 게놈에 존재하는 한 쌍의 비코딩 RNA (이른바 바이러스 연관 (VA) RNA I 및 II)로 표시되고, 각각 약 170개의 뉴클레오타이드 길이이며, 약 60개의 뉴클레오타이드로 분리되어 있다. 일반적으로, VA RNA I 및 II가 모두 존재하지만, VA RNA I만이 존재하는 경우 (그룹 A 바이러스 및 일부 그룹 B 바이러스)가 존재한다. 이들 RNA는 바이러스의 세포 방어 메커니즘 간섭과 관련된 것으로 공지되어 있다. 또한, VA RNA I 및 II는 세포 효소에 의해 마이크로RNA로 추가 가공된다. 그러나 이들 마이크로RNA의 정확한 기능은 공지되어 있지 않다.

공지된 아데노바이러스의 서열을 분석함으로써, 본 발명자들은 본 발명의 게놈의 VA RNA I 및 II가 다른 그룹 C 아데노바이러스의 VA RNA I 및 II 서열 (예를 들어 인간 Ad5 및 Ad2뿐만 아니라, 그룹 C에 속하는 많은 침팬지 단리물)과 유사한 것이 아니라, 그룹 B 및 E의 VA RNA I 및 VA RNA II와 더 근사하게 유사함을 발견하였다. 그룹 내 및 그룹 간 VA RNA I 및 II 서열의 평균 서열 동일성을 계산하였으며, 이는 하기 표 3에 제시되어 있다.

따라서, 이들 RNA는 바이러스의 더 높은 복제를 야기하는 것으로 여겨진다. 본 발명자들의 최적 정보에 따르면, VA RNA는 현재까지는 아데노바이러스의 증식성 향상과 관련된 것으로 밝혀진 바 없다.

실시예 6: Gad 벡터 면역원성

HIV-1 gag (서열번호 74)를 인코딩하는 2개의 GADNOU 벡터 (GADNOU19 GAG (DE1E3), 서열번호 72 및 GADNOU20 GAG (DE1E3), 서열번호 73)의 면역원성을 BALB/c 마우스에서 평가하였다. 그룹당 6마리의 동물을 각 GADNOU 벡터의 증가된 투여량으로 근육내 면역화시켰다. 3주 후 HIV gag 메이저 H-2 Kd CD8+ 에피토프 (AMQMLKETI)를 인코딩하는 9량체 펩타이드를 항원으로 사용하여 수집된 비장 세포에서 ELISpot을 수행하였다. 데이터는 시험된 3x10^7 vp (바이러스 입자)의 최고 투여량에서 두 벡터에 의해 강한 면역원성이 유도되었음을 보여준다. 또한 3x10^6 vp의 저투여량에서, 두 벡터는 여전히 백신화된 마우스의 50%에서 HIV-1 gag 특이적 T 세포 반응을 유도할 수 있었다 (도 5).

SEQUENCE LISTING <110> NOUSCOM <120> GREAT APES ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF <130> 854-10 PCT <150> EP17179825.9 <151> 2017-07-05 <160> 74 <170> PatentIn version 3.5 <210> 1 <211> 37184 <212> DNA <213> Great Ape Adenovirus <400> 1 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggtcg ctgcagatga tgaacttgaa gatgaagaag 19440 cgcaagcaca agaggaagcc cctgtgaaaa aaattcatgt atatgctcag gcgcctcttt 19500 ctggcgaaaa gatttccaag gatggtatcc aaataggtac tgaagtcgta ggagatacat 19560 ctaaggacac ttttgcagat aaaacattcc aacccgaacc tcagataggc gagtctcagt 19620 ggaacgaggc tgatgccaca gcagcaggag gtagagtttt gaaaaagact acccctatga 19680 gaccttgcta tggatcctat gccaggccta ccaatgccaa cgggggtcaa ggaattatgg 19740 ttgccaatga acaaggagtg ttggagtcta aagtagaaat gcaatttttc tctaacacca 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtacagcg 19860 aagatgtcca cttggaatct cccgatactc atctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa aatcatgttg ggtcagcaag ccatgcccaa cagacccaac ctcattggat 19980 ttagagataa tttcattggg cttatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaggc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 catatcagct tctgcttgat tcaattgggg atagaaccag atacttctcc atgtggaacc 20160 aggcagtgga tagctatgat ccagatgtca gaattattga aaaccatggg actgaggatg 20220 aactgcccaa ctactgcttc cctttgggcg gcataggagt tactgatact tatcaaggga 20280 taaaaaatac caatggcaat ggtcagtgga ccaaagatga tcagttcgcg gaccgcaacg 20340 aaataggggt gggaaacaac ttcgccatgg agatcaacat ccaggccaac ctttggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcgcc caccatgcgc gagggtcagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac ttttgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgccgcct gcatgacggg ttccaccgag caagagctca 21900 gggccattgc cagagacctg ggatgcggac cctatttttt gggcacctat gacaaacgct 21960 tcccgggctt tatctcccga gacaagctcg cctgcgccat tgtcaacacg gccgcgcgcg 22020 agaccggggg cgtgcactgg ctggcctttg gctgggaccc gcgctccaaa acttgctacc 22080 tctttgaccc ctttggcttc tccgatcagc gcctcaggca gatttatgag tttgagtacg 22140 aggggctgct gcgccgcagc gcgctcgcct cctcgcccga ccgctgcatc acccttgaga 22200 agtccaccga aaccgtgcag gggccccact cggccgcctg cggtctcttc tgttgcatgt 22260 ttttgcacgc ctttgtgcac tggcctcaga gtcccatgga ttgcaacccc accatgaact 22320 tgctaaaggg agtgcccaac gccatgctcc agagccccca ggtccagccc accctgcgcc 22380 gcaaccagga acagctttac cgcttcctgg agcgccactc cccctacttc cgcagccaca 22440 gcgcgcgcat ccggggggcc acctcttttt gccacttgca agaaaacatg caagacggaa 22500 aatgatgtac agcatgcttt taataaatgt aaagactgtg cactttaatt atacacgggc 22560 tctttctggt tatttattca acaccgccgt cgccatttag aaatcgaaag ggttctgccg 22620 tgcgtcgccg tgcgccacgg gcagagacac gttgcgatac tggaagcggc tcgcccactt 22680 gaactcgggc accaccatgc ggggcagtgg ttcctcgggg aagttctcgc tccacagggt 22740 gcgggtcagc tgcagcgcgc tcaggaggtc gggagccgag atcttgaagt cgcagttggg 22800 gccggaaccc tgcgcgcgcg agttgcggta cacggggttg cagcactgga acaccagcag 22860 ggccggatta ttcacgctgg ccagcaggct ctcgtcgctg atcatgtcgc tgtccagatc 22920 ctccgcgttg ctcagggcga atggggtcat cttgcagacc tgcctgccca ggaaaggcgg 22980 gagcccaggc ttgccgttgc agtcgcagcg caggggcatt agcaggtgcc cacggcccga 23040 ctgcgcctgc gggtacaacg cgcgcatgaa ggcttcgatc tgcctaaaag ccacctgggt 23100 cttggctccc tccgaaaaga acatcccaca ggacttgctg gagaactggt tcgcgggaca 23160 gctggcatcg tgcaggcagc agcgcgcgtc agtgttggca atctgcacca cgttgcgacc 23220 ccaccggttt ttcactatct tggccttgga agcctgctcc tttagcgcgc gctggccgtt 23280 ctcgctggtc acatccatct ctatcacctg ttccttgttg atcatgtttg tcccgtgcag 23340 acactttagg tcgccctccg tctgggtgca gcggtgctcc cacagcgcgc aaccggtggg 23400 ctcccaattc ttgtgggtca cccccgcgta ggcctgcagg taggcctgca ggaagcgccc 23460 catcatggtc ataaaggtct tctggctcgt aaaggtcagc tgcaggccgc gatgctcttc 23520 gttcagccag gtcttgcaga tggcggccag cgcctcggtc tgctcgggca gcatcttaaa 23580 atttgtcttc aggtcgttat ccacgtggta cttgtccatc atggcacgcg ccgcctccat 23640 gcccttctcc caggcggaca ccatgggcag gcttaggggg tttatcactt ccagcggcga 23700 ggacaccgta ctttcgattt cttcttcctc cccctcttcc cggcgcgcgc ccccgctgtt 23760 gcgcgctctt accgcctgca ccaaggggtc gtcttcaggc aagcgccgca ccgagcgctt 23820 gccgcccttg acctgcttga tcagtaccgg cgggttgctg aagcccacca tggtcagcgc 23880 cgcctgctct tcttcgtctt cgctgtctac cactatttct ggggaggggc ttctccgctc 23940 tgcggcaaag gcggcggatc gcttcttttt tttcttggga gccgccgcga tggagtccgc 24000 cacggcgacc gaggtcgagg gcgtggggct gggggtgcgc ggtaccaggg cctcgtcgcc 24060 ctcggactct tcctctgact ccaggcggcg gcggagtcgc ttctttgggg gcgcgcgcgt 24120 cagcggcggc ggagacgggg acggggacgg ggacgggacg ccctccacag ggggtggtct 24180 tcgcgcagac ccgcggccgc gctcgggggt cttctcgcgc tggtcttggt cccgactggc 24240 cattgtatcc tcctcctcct aggcagagag acataaggag tctatcatgc aagtcgagaa 24300 ggaggagagc ttaaccaccc cctcagagac cgccgatgcg cccgccgtcg ccgtcgcccc 24360 cgctaccgcc gacgcgcccg ccacaccgag cgacaccccc acggaccccc ccgccgacgc 24420 acccctgttc gaggaagcgg ccgtggagca ggacccgggc tttgtctcgg cagaggagga 24480 tttgcaagag gaggagaata aggaggagaa gccctcagtg ccaaaagatc ataaagagca 24540 agacgagcac gacgcagacg cacaccaggg tgaagtcggg cggggggacg gagggcatgg 24600 cggcgccgac tacctagacg aaggaaacga cgtgctcttg aagcacctgc atcgtcagtg 24660 cgccatcgtc tgcgacgctc tgcaggagcg cagcgaggtg cccctcagcg tggcggaggt 24720 cagccgcgcc tacgagctca gcctcttttc cccccgggtg cccccccgcc gccgcgaaaa 24780 cggcacatgc gagcccaacc cgcgcctcaa cttctacccc gcctttgtgg tgcccgaggt 24840 cctggccacc tatcacatct tctttcaaaa ttgcaagatc cccatctcgt gccgcgccaa 24900 ccgtagccgc gccgataaga tgctggccct gcgccagggc gaccacatac ctgatatcgc 24960 cgctttggaa gatgtgccaa agatcttcga gggtctgggg cgcaacgaga agcgggcagc 25020 aaactctctg caacaggaaa acagcgaaaa tgagagtcac actggagcgc tggtggagct 25080 ggagggcgac aacgcccgcc tggcggtgct caagcgcagc atcgaggtca cccactttgc 25140 ctaccccgcg ctcaacctgc cccccaaagt catgaacgcg gtcatggacg ggctgatcat 25200 gcgccgcggc cggcccctcg ctccagatgc aaacttgcat gaggagaccg aggacggtca 25260 gcccgtggtc agcgacgagc agctgacgcg ctggctggag agcgcggacc ccgccgaact 25320 ggaggagcgg cgcaagatga tgatggccgc ggtgctggtc accgtagagc tggagtgtct 25380 gcagcgcttc ttcggtgacc ccgagatgca gagaaaggtc gaggagaccc tacactacac 25440 cttccgccag ggctacgtgc gccaggcttg caagatctcc aacgtggagc tcagcaacct 25500 ggtgtcctac ctgggcatct tgcatgaaaa ccgccttggg cagagcgtgc tacactccac 25560 cctgcgcggg gaggcgcgcc gcgactacgt gcgcgactgc gtttacctct tcctctgcta 25620 cacctggcag acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga 25680 gctggagaag cttctgcagc gcgcgctcaa agacctctgg acgggcttca acgagcgctc 25740 ggtggccgcc gcgctagccg acctcatctt ccccgagcgc ctgctcaaaa ccctccagca 25800 ggggctgccc gacttcacca gccaaagcat gttgcaaaat tttaggaact ttatcctgga 25860 gcgttctggc atcctacccg ccacctgctg cgccctgccc agcgactttg tccccctcgt 25920 gtaccgcgag tgccccccgc cgctgtgggg ccactgctac ctgttccaac tggccaacta 25980 cctgtcctac cacgcggacc tcatggagga ctccagcggc gaggggctca tggagtgcca 26040 ctgccgctgc aacctctgca cgccccaccg ctccctggtc tgcaacaccc aactgctcag 26100 cgagagtcag attatcggta ccttcgagct acagggtccg tcctcctcag acgagaagtc 26160 cgcggctccg gggctaaaac tcactccggg gctgtggact tccgcctacc tgcgcaaatt 26220 tgtacctgaa gactaccacg cccacgaaat caggttttac gaggaccaat cccgcccgcc 26280 caaggcggag ctgaccgcct gcgtcatcac ccagggcgag atcctaggcc aattgcaagc 26340 catccaaaaa gcccgccaag agtttttgct gaagaggggt cggggggtgt atctggaccc 26400 ccagtcgggt gaggagctca acccggttcc cccgctgcca ccgccgcggg accttgcttc 26460 ccaggataag catcgccatg gctcccagaa agaagcagca gcggccgccg ctgccgccgc 26520 cccacatgct ggaggaagag gaggaatact gggacagtca ggcagaggag gtttcggacg 26580 aggaggagcc ggagacggag atggaagagt gggaggagga cagcttagac gaggaggctt 26640 ccgaagccga agaggcaggc gcaacaccgt caccctcggc cgcagccccc tcgcaggcgc 26700 ccccgaagtc cgctcccagc atcagcagca acagcagcgc tataacctcc gctcctccac 26760 cgccgcgacc cacggccgac cgcagaccca accgtagatg ggacaccacc ggaaccgggg 26820 ccggtaagtc ctccgggaga ggcaagcaag cgcagcgcca aggctaccgc tcgtggcgcg 26880 ctcacaagaa cgccatagtc gcttgcttgc aagactgcgg ggggaacatc tccttcgccc 26940 gccgcttcct gctcttccac cacggtgtgg ccttcccccg taacgtcctg cattactacc 27000 gtcatctcta cagcccctac tgcggcggca gtgagccaga ggcggccagc ggcggcggcg 27060 cccgtttcgg tgcctaggaa gacccagggc aagacttcag ccaagaaact cgcggcgacc 27120 gcggcgaacg cggtcgcggg ggccctgcgc ctgacggtga acgaacccct gtcgacccgc 27180 gaactgagga accgaatctt ccccactctc tatgccatct tccagcagag cagagggcag 27240 gatcaggaac tgaaagtaaa aaacaggtct ctgcgctccc tcacccgcag ctgtctgtat 27300 cacaagagcg aagaccagct tcggcgcacg ctggaggacg ctgaggcact cttcagcaaa 27360 tactgcgcgc tcactcttaa ggactagctc cgcgcccttc tcgaatttag gcgggaacgc 27420 ctacgtcatc gcagcgccgc cgtcatgagc aaggacattc ccacgccata catgtggagc 27480 tatcagccgc agatgggact cgcggcgggc gcctcccaag actactccac ccgcatgaac 27540 tggctcagtg ccggcccaca catgatctca caggttaatg acatccgcac ccatcgaaac 27600 caaatattgg tgaagcaggc ggcaattacc accacgcccc gcaataatcc caaccccagg 27660 gagtggcccg cgtccctggt gtatcaggaa attcccggcc ccaccaccgt actacttccg 27720 cgtgattccc aggccgaagt ccaaatgact aactcagggg cacagctcgc gggcggctgt 27780 cgtcacaggg tgcggcctcc tcgccagggt ataactcacc tggagatccg aggcagaggt 27840 attcagctca acgacgagtc ggtgagctcc tcgctcggtc tcagacctga cgggaccttc 27900 cagatagccg gagccggccg atcttccttc acgccccgcc aggcgtacct gactctgcag 27960 agctcgtcct cggcgccgcg ctcgggcggc atcgggactc tccagttcgt gcaggagttt 28020 gtgccctcgg tctacttcaa ccccttctcg ggctctcccg gtcgctaccc ggaccagttt 28080 atcccgaact ttgacgccgc gagggactcg gtggacggct acgactgaat gtcgggtgga 28140 cccggtgcag agcaacttcg cctgaagcac cttgaccact gccgccgccc tcagtgcttt 28200 gcccgctgtc agaccggtga gttccagtac ttttccctgc ccgactcgca cccggacggc 28260 ccggcgcacg gggtgcgctt tttcatcccg agtcaggtcc gctctaccct aatcagggag 28320 ttcaccgccc gtcccctact ggcggagttg gaaaaggggc cttctatcct aaccattgcc 28380 tgcatttgct ctaaccctgg attacaccaa gatctttgct gtcatttgtg tgctgagtat 28440 aataaaggct gagatcagaa tctactcggg ctcctgtcgc catcctgtca acgccaccgt 28500 ccaagcccgg cccgatcagc ccgaggtgaa cctcacctgt ggtctgcacc ggcgcctgag 28560 gaaataccta gcttggtact acaacagcac tccctttgtg gtttacaaca gctttgacca 28620 ggacggggtc tcactgaggg ataacctctc gaacctgagc tactccatca ggaagaacaa 28680 caccctcgag ctacttcctc cttacctgcc cgggacttac cagtgtgtca ccggcccctg 28740 cacccacacc cacctgttga tcgtaaacga ctctcttccg agaacagacc tcaataactc 28800 ctctccgcag ttccccagaa caggaggtga gctcaggaaa ccccgggtaa agaagggtgg 28860 acaagagtta acacttgtgg ggtttctggt atatgtgacg ctggtggtgg ctcttttgat 28920 taaggctttt ccttccatgt ctgaactatc cctcttcttt tatgaacaac tcgactagtg 28980 ctaacgggac cctacccaac gaatcgggat tgaatatcgg taaccaggtt gcagtttcac 29040 ttttgattac cttcatagtc ctcttcctgc tagtgctgtc gcttctgtgc ctgcggatcg 29100 ggggctgctg catccacgtt tatatctggt gctggctgtt tagaaggttc ggagaccacc 29160 gcaggtagaa taatgctgct taccctcttt gtcctggcgc tggctgccag ctgccaagcc 29220 ttttccgagg ctgacttcat agagccccag tgcaatatca cttataaatc tgaacgtgcc 29280 atctgtacta ttctaatcaa atgtgttact caacacgata aggtgactgt taaatacaaa 29340 gatcaattaa aaaaagacgc actttacagc agctggcaac caggagatga tcaaaaatac 29400 aatgtaaccg tcttccaggg caaactctcc aaaacttaca attacaattt cccatttgag 29460 cagatgtgtg actttgtcat gtacatggaa aagcagtaca agctgtggcc tccaactccc 29520 cagggctgtg tggaaaatcc aggctctttc tgtatgatct ctctctgtgt aactgtgctg 29580 gcactaatac tcacgcttct gtatctcaga tttaaatcaa ggcaaagctt cattgatgaa 29640 aagaaaatgc cataatcgct caacgcttga ttgctaacac cgggttttta tccgcagaat 29700 gattggaatc accctactaa tcacctccct ccttgcgatt gcccatgggt tggaacgaat 29760 cgaagtccct gtgggggcca atgttaccct ggtggggcct gtcggcaatg ctacattaat 29820 gtgggaaaaa tatactaaaa atcaatgggt ttcttactgc actaacaaaa acagccacaa 29880 gcccagagcc atctgcgatg ggcaaaatct aaccttgatt gatgttcaat tgctggatgc 29940 gggctactat tatgggcagc tgggtacaat gattaattac tggagacccc acagagatta 30000 catgcttcac gtagtaaagg gtcccattag cagcccaacc accacctcta ccacacccac 30060 taccaccact actcccacca ccagcactgc cgcccagcct cctcatagca gaacaaccac 30120 ttttatcaat tccaagtccc actcccccca cattgccggc gggccctccg cctcagactc 30180 cgagaccacc gagatctgct tctgcaaatg ctctgacgcc attgcccagg atttggaaga 30240 tcacgaggaa gatgagcatg actacgcaga tgcatgccag gcatcagagg cagaagcgct 30300 accggtggcc ctaaaacagt atgcagactc ccacaccacc cccaaccttc ctccaccttc 30360 ccagaagcca agtttcctgg gggaaaatga aactctgcct ctttccatac tagctctgac 30420 atctgttgct attttggccg ctctgctggt gcttctatgc tctatatgct acctgatctg 30480 ctgcagaaag aaaaaatctc acggccatgc tcaccagccc ctcatgcact tcccttaccc 30540 tccagagctg ggcgaccaca aactttaagt ctgcagtagc tatctgccca tcccttgtca 30600 gtcgacagcg atgagcccca ctaatctaac agcctctgga cttacaacat tgtctcttaa 30660 tgagaccacc gctcctcaag acctgtacga tggtgtctcc gcgctggtta accagtggga 30720 tcacctgggc atatggtggc tcctcatagg agcagtgacc ctgtgcctaa tcctggtctg 30780 gatcatctgc tgcatcaaaa gcagaagacc caggcggcgg cccatctaca ggcccttcgt 30840 catcacacct gaagataatg atgatgatga caccacctcc aggctgcaga gcctaaagca 30900 gctactcttc tcttttacag catggtaaat tgaatcatgc cccgcatttt catctacttg 30960 cttctccttc cactttttct gggctcctct acattggcca ctgtgtccca catcgaggta 31020 gactgcctca cgcccttcac agtctacctg cttttcggct ttgtcatctg cacctttgtc 31080 tgcagcgtta tcactgtagt gatctgcttc atacagtgca tcgactacat ctgtgtgcgg 31140 gtggcctact ttagacacca cccccagtat cgcaacaggg acatagcggc tctcctaaga 31200 cttgtttaaa tcatggccaa attacctgtg attggtcttc tgattatctg ctgcgtccta 31260 gccgcgattg ggactcaacc taataccacc accagcgctc ccagaaagag acatgtatcc 31320 tgcagcttca agcgtccctg gaatataccc caatgcttta ctgatgaacc tgaaatctct 31380 ttggcttggt acttcagcgt caccgccctt ctcatcttct gcagtacggt tattgctctt 31440 gccatctacc cttcccttaa cctgggctgg aatgctgtca actctatgga atatcccacc 31500 ttcccagaac cagacctgcc agacctggtt gttctaaacg cgtttcctcc tcctccagtt 31560 caaaatcagt ttcgccctcc gtcccctacg cccactgagg tcagctactt taatctaaca 31620 ggcggagatg actgaaaacc tagacctaga aatggacggt ctctgcagcg agcaacgcac 31680 actagagagg cgccggcaaa aagcagagct cgagcgtctt aaacaagagc tccaagacgc 31740 cgtggccata caccagtgca aaaaagggct cttctgtctg gtaaaacagg ccacgctcac 31800 ctatgaaaaa acaggtgaca cccaccgcct aggatacaag ctgcccacac agcgccaaaa 31860 gtttgccctt atgataggtg aacaacccat caccgtcacc cagcactccg tggagacaga 31920 aggctgcatt catgctccct gcaggggcgc tgactgcctc tacaccttga tcaaaaccct 31980 ctgcggtctc agagacctta tccctttcaa ttgatcataa ctgtaatcaa taaaaaatca 32040 cttacttgaa atctgatagc aagactctgt ccaatttttt cagcaacact tccttcccct 32100 cctcccaact ctggtactct aggcgcctcc tagctgcaaa cttcctccac agtctgaagg 32160 gaatgtcaga ttcctcctcc tgtccctccg cacccacgat cttcatgttg ttacagatga 32220 aacgcgcgag atcgtctgac gagaccttca accccgtgta cccctacgat accgagatcg 32280 ctccgacttc tgtccctttc cttacccctc cctttgtatc atccgcagga atgcaagaaa 32340 atccagctgg ggtgctgtcc ctgcacctgt cagagcccct taccacccac aatggggccc 32400 tgactctaaa aatggggggc ggcctgaccc tggacaagga agggaatctc acttcccaaa 32460 acatcaccag tgtcgatccc cctctcaaaa aaagcaagaa caacatcagc cttcagaccg 32520 ccgcacccct cgccgtcagc tccggggccc taaccctttt tgccactccc cccctagcgg 32580 tcagtggcga caaccttact gtgcagtctc aggcccctct tactttggaa gactcaaaac 32640 taactctggc caccaaagga cccctaactg tgtccgaagg caaacttgtc ctagaaacag 32700 agcctcccct gcatgcaagt gacagcagta gcctgggcct tagcgtcacg gccccactta 32760 gcattaacaa tgacagccta ggactagaca tgcaagcgcc catcagctct cgagatggaa 32820 aactggctct aacagtggcg gcccccctaa ctgtggccga gggtatcaat gctttggcag 32880 tagccacagg taatggtatt ggactaaatg aaaccaacac acacctgcag gcaaaactgg 32940 tcgcgcccct aggctttgat accaacggca acattaagct aagcgtcgca ggaggcatga 33000 ggctaaacaa taacacactg atactagatg taaactaccc atttgaggct caaggccaac 33060 tgagcctaag agtgggctcg ggcccactat atgtagattc tagtagtcat aacctaacca 33120 ttagatgcct taggggattg tatgtaacat cttctaacaa ccaaaacggt ctagaggcca 33180 acattaaact aacaaaaggc cttgtgtatg acggaaatgc catagcagtt aatgttggca 33240 aagggctgga atacagccct actggcacaa cagaaaaacc tatacagact aaaataggtc 33300 taggcatgga gtatgacact gagggagcca tgatgacaaa actaggctct ggactaagct 33360 ttgacaattc aggagccatt gtggtgggaa acaaaaatga tgacaggctt actttgtgga 33420 ccacaccgga cccatcgccc aactgtcaga tttactctga aaaagatgct aaactaacct 33480 tggtactgac taaatgtggc agtcaggttg taggcacagt atctattgcc gctcttaaag 33540 gtagccttgt gccaatcact agtgcaatca gtgtggttca gatataccta aggtttgatg 33600 aaaatggggt gctgatgagt aactcttcac ttaatggcga atactggaat tttagaaacg 33660 gagactcaac taatggcaca ccatatacaa acgcagtggg ttttatgcct aatctactgg 33720 cctatcctaa aggtcaaact acaactgcaa aaagtaacat tgtcagccag gtctacatga 33780 acggggacga tactaaaccc atgacattta caatcaactt caatggcctt agtgaaacag 33840 gggatacccc tgtcagtaaa tattccatga cattctcatg gaggtggcca aatggaagct 33900 acatagggca caattttgta acaaactcct ttactttctc ctacatcgcc caagaataaa 33960 gaaagcacag agatgcttgt ttttgatttc aaaattgtgt gcttttattt attttcaagc 34020 ttacagtatt tccagtagtc attagaatag agcttaatta aactgcatga gaacccttcc 34080 acatagctta aattatcacc agtgcaaatg gaaaaaaatc aacatacctt tttatccaga 34140 tatcaaagaa ctctagtggt cagttttccc ccaccctccc agctcacaga atacacagtc 34200 ctttcccccc ggctggcttt aaacaacact atctcattgg taacagacat atttttaggt 34260 gtaataatcc acacggtctc ttggcgggcc aaacgctggt ctgtgatgtt aataaactcc 34320 ccaggcagct ctttcaagtt cacgtcgctg tccaactgct gaagcgctcg cggctccgac 34380 tgcgcctcta gcggaggcaa cggcagcacc cgatccttga tctataaagg agtagagtca 34440 taatccccca taagaatagg gcggtgatgc agcaacaagg cgcgcagcaa ctcctgccgc 34500 cgcctctccg tacgacagga atgcaacggg gtggtggtct cctccgcgat aatccgcacc 34560 gctcgcagca tcagcatcct cgtcctccgg gcacagcagc gcatcctgat ctcactgaga 34620 tcggcgcagt aagtgcagca caacaccaag atgttattta agatcccaca gtgcaaagca 34680 ctgtacccaa agctcatggc gggaaggaca gcccccacgt gaccatcgta ccagatcctc 34740 aggtaaatca aatgacgacc tctcataaac acgctggaca tatacatcac ctccttgggc 34800 atgagctgat tcaccacctc tcgataccac aggcatcgct gattaattaa agacccctcg 34860 agcaccatcc tgaaccagga agccagcacc tgaccccccg ccaggcactg cagggacccc 34920 ggtgaatcgc agtggcagtg aagactccag cgctcgtagc cgtgaaccat agagctggtc 34980 attatatcca cattggcaca acacagacac actttcatac actttttcat gattagcagc 35040 tcctctctag tcaagaccat atcccaagga atcacccact cttgaatcaa ggtaaatccc 35100 acacagcagg gcaggcctct cacataactc acgttatgca tagtgagcgt gtcgcaatct 35160 ggaaataccg gatgatcttc catcaccgaa gcccgggtct ccgtctcaaa gggaggtaaa 35220 cggtccctcg tgtagggaca gtggcgggat aatcgagatc gtgttgaacg tagagtcatg 35280 ccaaagggaa cagcggacgt actcatattt cctccagcag aaccaagtgc gcgcgtggca 35340 gctatccctg cgtcttctgt ctcgccgcct gccccgctcg gtgtagtagt tgtaatacag 35400 ccactccctc agaccgtcaa ggcgctccct ggcgtccgga tctataacaa caccgtcctg 35460 cagcgccgcc ctgatgacat ccaccaccgt agagtatgcc aagcccagcc acgaaatgca 35520 ctcactttga cagcgagaga taggaggagc gggaagagat ggaagaacca tgatagtaaa 35580 agaactttta ttccaatcga tcctctacaa tgtcaaagtg tagatctatc agatggcact 35640 ggtctcctcc gctgagtcga tcaaaaataa cagctaaacc acaaacaaca cgattggtca 35700 aatgctgcac aagggcttgc agcataaaat cgcctcgaaa gtccaccgca agcataacat 35760 caaagccacc gcccctatca tgatctatga taaaaacccc acagctatcc accagaccca 35820 tatagttttc atctctccat cgtgaaaaaa tatttacaag ctcctccttt aaatcacctc 35880 caaccaattc aaaaagttga gccagaccgc cctccacctt cattttcagc atgcgcatca 35940 tgattgcaaa aattcaggct cctcagacac ctgtataaga ttgagaagcg gaacgttaac 36000 atcaatgttt cgctcgcgaa gatcgcgcct cagtgcaagc atgatataat cccacaggtc 36060 ggagcggatc agcgaggaca tctccccgcc aggaaccaac tcaacggagc ctatgctgat 36120 tataatacgc atattcgggg ctatgctaac cagcacggcc cccaaatagg cgtactgcat 36180 aggcggcgac aaaaagtgaa cagtttgggt taaaaaatca ggcaaacact cgcgcaaaaa 36240 agcaagaaca tcataaccat gctcatgcaa atagatgcaa gtaagctcag gaacgaccac 36300 agaaaaatgc acaatttttc tctcaaacat gactgcgagc cctgcaaaaa ataaaaaaga 36360 aacattacac aagagtagcc tgtcttacaa tgggatagac tactctaacc aacataagac 36420 gggccacgac atcgcccgcg tggccataaa aaaaattatc cgtgtgatta aaaagaagca 36480 cagatagctg gccagtcata tccggagtca tcacgtgcga acccgtgtag acccccgggt 36540 tggacacatc ggccaaacaa agaaagcggc caatgtatcc cggaggaatg ataacactaa 36600 gacgaagata caacagaata accccatggg ggggaataac aaagttagta ggtgaataaa 36660 aacgataaac acccgaaact ccctcctgcg taggcaaaat agcgccctcc ccttccaaaa 36720 caacatacag cgcttccaca gcagccatga caaaagactc aaaacactca aaagactcag 36780 tcttaccagg aaaataaaag cactctcaca gcaccagcac taatcagagt gtgaagaggg 36840 ccaagtgccg aacgagtata tataggaatt aaaaatgacg taaatgtgta aaggtcaaaa 36900 aacgcccaga aaaatacaca gaccaacgcc cgaaacgaaa acccgcgaaa aaatacccag 36960 aagttcctca acaaccgcca cttccgcttt cccacgatac gtcacttcct caaaaatagc 37020 aaactacatt tcccacatgt acaaaaccaa aacccctccc cttgtcaccg cccacaactt 37080 acataatcac aaacgtcaaa gcctacgtca cccgccccgc ctcgccccgc ccacctcatt 37140 atcatattgg cctcaatcca aaataaggta tattattgat gatg 37184 <210> 2 <211> 37184 <212> DNA <213> Great Ape Adenovirus <400> 2 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggt cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggctcctaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaac caggtggtcg ctgcagatga tgaacttgag gatgaggaag 19440 cgcaggcaca agaggaagcc cctgtgaaaa aaattcatgt gtatgctcag gcgcctcttt 19500 ccggcgaaaa gatttccaag gatggcatcc aaataggcac tgaagtcgta ggagatacat 19560 ctaaggacac ttttgccgac aaaacattcc agcccgaacc tcagataggc gaatctcagt 19620 ggaatgaagc tgatgccaca gcagcaggag gtagggtttt gaagaagact actcccatga 19680 ggccttgtta tggatcttat gctaggccta ccaatgccaa cggaggccaa ggaattatgg 19740 ttgccaatga acaaggagtg ttggagtcta aagtagaaat gcagtttttc tctaacacca 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtatagtg 19860 aagatgtcca cttggaatct cccgatactc acctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa aatcatgttg ggccaacagg ctatgcccaa taggcccaat cttattggat 19980 ttagagataa tttcattggg ctcatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaagc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 cgtatcagct tttgcttgat tccattgggg atagaaccag atatttctcc atgtggaacc 20160 aggcagtgga tagttatgac ccagatgtca gaatcattga aaaccacggg actgaggacg 20220 aactgcctaa ctactgtttt cctctgggcg gcattggagt tacagatact tatcaaggga 20280 taaaaaatac taatggcaat ggtcaatgga ccaaagatga tcagtttgcg gaccgcaatg 20340 aaataggggt gggaaacaac tttgccatgg agatcaacat ccaggccaac ctctggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcgcc caccatgcgc gagggtcagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac ttttgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgccgcct gcatgacggg ttccaccgag caagagctca 21900 gggccattgc cagagacctg ggatgcggac cctatttttt gggcacctat gacaaacgct 21960 tcccgggctt tatctcccga gacaagctcg cctgcgccat tgtcaacacg gccgcgcgcg 22020 agaccggggg cgtgcactgg ctggcctttg gctgggaccc gcgctccaaa acttgctacc 22080 tctttgaccc ctttggcttc tccgatcagc gcctcaggca gatttatgag tttgagtacg 22140 aggggctgct gcgccgcagc gcgctcgcct cctcgcccga ccgctgcatc acccttgaga 22200 agtccaccga aaccgtgcag gggccccact cggccgcctg cggtctcttc tgttgcatgt 22260 ttttgcacgc ctttgtgcac tggcctcaga gtcccatgga ttgcaacccc accatgaact 22320 tgctaaaggg agtgcccaac gccatgctcc agagccccca ggtccagccc accctgcgcc 22380 gcaaccagga acagctttac cgcttcctgg agcgccactc cccctacttc cgcagccaca 22440 gcgcgcgcat ccggggggcc acctcttttt gccacttgca agaaaacatg caagacggaa 22500 aatgatgtac agcatgcttt taataaatgt aaagactgtg cactttaatt atacacgggc 22560 tctttctggt tatttattca acaccgccgt cgccatttag aaatcgaaag ggttctgccg 22620 tgcgtcgccg tgcgccacgg gcagagacac gttgcgatac tggaagcggc tcgcccactt 22680 gaactcgggc accaccatgc ggggcagtgg ttcctcgggg aagttctcgc tccacagggt 22740 gcgggtcagc tgcagcgcgc tcaggaggtc gggagccgag atcttgaagt cgcagttggg 22800 gccggaaccc tgcgcgcgcg agttgcggta cacggggttg cagcactgga acaccagcag 22860 ggccggatta ttcacgctgg ccagcaggct ctcgtcgctg atcatgtcgc tgtccagatc 22920 ctccgcgttg ctcagggcga atggggtcat cttgcagacc tgcctgccca ggaaaggcgg 22980 gagcccaggc ttgccgttgc agtcgcagcg caggggcatt agcaggtgcc cacggcccga 23040 ctgcgcctgc gggtacaacg cgcgcatgaa ggcttcgatc tgcctaaaag ccacctgggt 23100 cttggctccc tccgaaaaga acatcccaca ggacttgctg gagaactggt tcgcgggaca 23160 gctggcatcg tgcaggcagc agcgcgcgtc agtgttggca atctgcacca cgttgcgacc 23220 ccaccggttt ttcactatct tggccttgga agcctgctcc tttagcgcgc gctggccgtt 23280 ctcgctggtc acatccatct ctatcacctg ttccttgttg atcatgtttg tcccgtgcag 23340 acactttagg tcgccctccg tctgggtgca gcggtgctcc cacagcgcgc aaccggtggg 23400 ctcccaattc ttgtgggtca cccccgcgta ggcctgcagg taggcctgca ggaagcgccc 23460 catcatggtc ataaaggtct tctggctcgt aaaggtcagc tgcaggccgc gatgctcttc 23520 gttcagccag gtcttgcaga tggcggccag cgcctcggtc tgctcgggca gcatcttaaa 23580 atttgtcttc aggtcgttat ccacgtggta cttgtccatc atggcacgcg ccgcctccat 23640 gcccttctcc caggcggaca ccatgggcag gcttaggggg tttatcactt ccagcggcga 23700 ggacaccgta ctttcgattt cttcttcctc cccctcttcc cggcgcgcgc ccccgctgtt 23760 gcgcgctctt accgcctgca ccaaggggtc gtcttcaggc aagcgccgca ccgagcgctt 23820 gccgcccttg acctgcttga tcagtaccgg cgggttgctg aagcccacca tggtcagcgc 23880 cgcctgctct tcttcgtctt cgctgtctac cactatttct ggggaggggc ttctccgctc 23940 tgcggcaaag gcggcggatc gcttcttttt tttcttggga gccgccgcga tggagtccgc 24000 cacggcgacc gaggtcgagg gcgtggggct gggggtgcgc ggtaccaggg cctcgtcgcc 24060 ctcggactct tcctctgact ccaggcggcg gcggagtcgc ttctttgggg gcgcgcgcgt 24120 cagcggcggc ggagacgggg acggggacgg ggacgggacg ccctccacag ggggtggtct 24180 tcgcgcagac ccgcggccgc gctcgggggt cttctcgcgc tggtcttggt cccgactggc 24240 cattgtatcc tcctcctcct aggcagagag acataaggag tctatcatgc aagtcgagaa 24300 ggaggagagc ttaaccaccc cctcagagac cgccgatgcg cccgccgtcg ccgtcgcccc 24360 cgctaccgcc gacgcgcccg ccacaccgag cgacaccccc acggaccccc ccgccgacgc 24420 acccctgttc gaggaagcgg ccgtggagca ggacccgggc tttgtctcgg cagaggagga 24480 tttgcaagag gaggagaata aggaggagaa gccctcagtg ccaaaagatc ataaagagca 24540 agacgagcac gacgcagacg cacaccaggg tgaagtcggg cggggggacg gagggcatgg 24600 cggcgccgac tacctagacg aaggaaacga cgtgctcttg aagcacctgc atcgtcagtg 24660 cgccatcgtc tgcgacgctc tgcaggagcg cagcgaggtg cccctcagcg tggcggaggt 24720 cagccgcgcc tacgagctca gcctcttttc cccccgggtg cccccccgcc gccgcgaaaa 24780 cggcacatgc gagcccaacc cgcgcctcaa cttctacccc gcctttgtgg tgcccgaggt 24840 cctggccacc tatcacatct tctttcaaaa ttgcaagatc cccatctcgt gccgcgccaa 24900 ccgtagccgc gccgataaga tgctggccct gcgccagggc gaccacatac ctgatatcgc 24960 cgctttggaa gatgtgccaa agatcttcga gggtctgggg cgcaacgaga agcgggcagc 25020 aaactctctg caacaggaaa acagcgaaaa tgagagtcac actggagcgc tggtggagct 25080 ggagggcgac aacgcccgcc tggcggtgct caagcgcagc atcgaggtca cccactttgc 25140 ctaccccgcg ctcaacctgc cccccaaagt catgaacgcg gtcatggacg ggctgatcat 25200 gcgccgcggc cggcccctcg ctccagatgc aaacttgcat gaggagaccg aggacggtca 25260 gcccgtggtc agcgacgagc agctgacgcg ctggctggag agcgcggacc ccgccgaact 25320 ggaggagcgg cgcaagatga tgatggccgc ggtgctggtc accgtagagc tggagtgtct 25380 gcagcgcttc ttcggtgacc ccgagatgca gagaaaggtc gaggagaccc tacactacac 25440 cttccgccag ggctacgtgc gccaggcttg caagatctcc aacgtggagc tcagcaacct 25500 ggtgtcctac ctgggcatct tgcatgaaaa ccgccttggg cagagcgtgc tacactccac 25560 cctgcgcggg gaggcgcgcc gcgactacgt gcgcgactgc gtttacctct tcctctgcta 25620 cacctggcag acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga 25680 gctggagaag cttctgcagc gcgcgctcaa agacctctgg acgggcttca acgagcgctc 25740 ggtggccgcc gcgctagccg acctcatctt ccccgagcgc ctgctcaaaa ccctccagca 25800 ggggctgccc gacttcacca gccaaagcat gttgcaaaat tttaggaact ttatcctgga 25860 gcgttctggc atcctacccg ccacctgctg cgccctgccc agcgactttg tccccctcgt 25920 gtaccgcgag tgccccccgc cgctgtgggg ccactgctac ctgttccaac tggccaacta 25980 cctgtcctac cacgcggacc tcatggagga ctccagcggc gaggggctca tggagtgcca 26040 ctgccgctgc aacctctgca cgccccaccg ctccctggtc tgcaacaccc aactgctcag 26100 cgagagtcag attatcggta ccttcgagct acagggtccg tcctcctcag acgagaagtc 26160 cgcggctccg gggctaaaac tcactccggg gctgtggact tccgcctacc tgcgcaaatt 26220 tgtacctgaa gactaccacg cccacgaaat caggttttac gaggaccaat cccgcccgcc 26280 caaggcggag ctgaccgcct gcgtcatcac ccagggcgag atcctaggcc aattgcaagc 26340 catccaaaaa gcccgccaag agtttttgct gaagaggggt cggggggtgt atctggaccc 26400 ccagtcgggt gaggagctca acccggttcc cccgctgcca ccgccgcggg accttgcttc 26460 ccaggataag catcgccatg gctcccagaa agaagcagca gcggccgccg ctgccgccgc 26520 cccacatgct ggaggaagag gaggaatact gggacagtca ggcagaggag gtttcggacg 26580 aggaggagcc ggagacggag atggaagagt gggaggagga cagcttagac gaggaggctt 26640 ccgaagccga agaggcaggc gcaacaccgt caccctcggc cgcagccccc tcgcaggcgc 26700 ccccgaagtc cgctcccagc atcagcagca acagcagcgc tataacctcc gctcctccac 26760 cgccgcgacc cacggccgac cgcagaccca accgtagatg ggacaccacc ggaaccgggg 26820 ccggtaagtc ctccgggaga ggcaagcaag cgcagcgcca aggctaccgc tcgtggcgcg 26880 ctcacaagaa cgccatagtc gcttgcttgc aagactgcgg ggggaacatc tccttcgccc 26940 gccgcttcct gctcttccac cacggtgtgg ccttcccccg taacgtcctg cattactacc 27000 gtcatctcta cagcccctac tgcggcggca gtgagccaga ggcggccagc ggcggcggcg 27060 cccgtttcgg tgcctaggaa gacccagggc aagacttcag ccaagaaact cgcggcgacc 27120 gcggcgaacg cggtcgcggg ggccctgcgc ctgacggtga acgaacccct gtcgacccgc 27180 gaactgagga accgaatctt ccccactctc tatgccatct tccagcagag cagagggcag 27240 gatcaggaac tgaaagtaaa aaacaggtct ctgcgctccc tcacccgcag ctgtctgtat 27300 cacaagagcg aagaccagct tcggcgcacg ctggaggacg ctgaggcact cttcagcaaa 27360 tactgcgcgc tcactcttaa ggactagctc cgcgcccttc tcgaatttag gcgggaacgc 27420 ctacgtcatc gcagcgccgc cgtcatgagc aaggacattc ccacgccata catgtggagc 27480 tatcagccgc agatgggact cgcggcgggc gcctcccaag actactccac ccgcatgaac 27540 tggctcagtg ccggcccaca catgatctca caggttaatg acatccgcac ccatcgaaac 27600 caaatattgg tgaagcaggc ggcaattacc accacgcccc gcaataatcc caaccccagg 27660 gagtggcccg cgtccctggt gtatcaggaa attcccggcc ccaccaccgt actacttccg 27720 cgtgattccc aggccgaagt ccaaatgact aactcagggg cacagctcgc gggcggctgt 27780 cgtcacaggg tgcggcctcc tcgccagggt ataactcacc tggagatccg aggcagaggt 27840 attcagctca acgacgagtc ggtgagctcc tcgctcggtc tcagacctga cgggaccttc 27900 cagatagccg gagccggccg atcttccttc acgccccgcc aggcgtacct gactctgcag 27960 agctcgtcct cggcgccgcg ctcgggcggc atcgggactc tccagttcgt gcaggagttt 28020 gtgccctcgg tctacttcaa ccccttctcg ggctctcccg gtcgctaccc ggaccagttt 28080 atcccgaact ttgacgccgc gagggactcg gtggacggct acgactgaat gtcgggtgga 28140 cccggtgcag agcaacttcg cctgaagcac cttgaccact gccgccgccc tcagtgcttt 28200 gcccgctgtc agaccggtga gttccagtac ttttccctgc ccgactcgca cccggacggc 28260 ccggcgcacg gggtgcgctt tttcatcccg agtcaggtcc gctctaccct aatcagggag 28320 ttcaccgccc gtcccctact ggcggagttg gaaaaggggc cttctatcct aaccattgcc 28380 tgcatttgct ctaaccctgg attacaccaa gatctttgct gtcatttgtg tgctgagtat 28440 aataaaggct gagatcagaa tctactcggg ctcctgtcgc catcctgtca acgccaccgt 28500 ccaagcccgg cccgatcagc ccgaggtgaa cctcacctgt ggtctgcacc ggcgcctgag 28560 gaaataccta gcttggtact acaacagcac tccctttgtg gtttacaaca gctttgacca 28620 ggacggggtc tcactgaggg ataacctctc gaacctgagc tactccatca ggaagaacaa 28680 caccctcgag ctacttcctc cttacctgcc cgggacttac cagtgtgtca ccggcccctg 28740 cacccacacc cacctgttga tcgtaaacga ctctcttccg agaacagacc tcaataactc 28800 ctctccgcag ttccccagaa caggaggtga gctcaggaaa ccccgggtaa agaagggtgg 28860 acaagagtta acacttgtgg ggtttctggt atatgtgacg ctggtggtgg ctcttttgat 28920 taaggctttt ccttccatgt ctgaactatc cctcttcttt tatgaacaac tcgactagtg 28980 ctaacgggac cctacccaac gaatcgggat tgaatatcgg taaccaggtt gcagtttcac 29040 ttttgattac cttcatagtc ctcttcctgc tagtgctgtc gcttctgtgc ctgcggatcg 29100 ggggctgctg catccacgtt tatatctggt gctggctgtt tagaaggttc ggagaccacc 29160 gcaggtagaa taatgctgct taccctcttt gtcctggcgc tggctgccag ctgccaagcc 29220 ttttccgagg ctgacttcat agagccccag tgcaatatca cttataaatc tgaacgtgcc 29280 atctgtacta ttctaatcaa atgtgttact caacacgata aggtgactgt taaatacaaa 29340 gatcaattaa aaaaagacgc actttacagc agctggcaac caggagatga tcaaaaatac 29400 aatgtaaccg tcttccaggg caaactctcc aaaacttaca attacaattt cccatttgag 29460 cagatgtgtg actttgtcat gtacatggaa aagcagtaca agctgtggcc tccaactccc 29520 cagggctgtg tggaaaatcc aggctctttc tgtatgatct ctctctgtgt aactgtgctg 29580 gcactaatac tcacgcttct gtatctcaga tttaaatcaa ggcaaagctt cattgatgaa 29640 aagaaaatgc cataatcgct caacgcttga ttgctaacac cgggttttta tccgcagaat 29700 gattggaatc accctactaa tcacctccct ccttgcgatt gcccatgggt tggaacgaat 29760 cgaagtccct gtgggggcca atgttaccct ggtggggcct gtcggcaatg ctacattaat 29820 gtgggaaaaa tatactaaaa atcaatgggt ttcttactgc actaacaaaa acagccacaa 29880 gcccagagcc atctgcgatg ggcaaaatct aaccttgatt gatgttcaat tgctggatgc 29940 gggctactat tatgggcagc tgggtacaat gattaattac tggagacccc acagagatta 30000 catgcttcac gtagtaaagg gtcccattag cagcccaacc accacctcta ccacacccac 30060 taccaccact actcccacca ccagcactgc cgcccagcct cctcatagca gaacaaccac 30120 ttttatcaat tccaagtccc actcccccca cattgccggc gggccctccg cctcagactc 30180 cgagaccacc gagatctgct tctgcaaatg ctctgacgcc attgcccagg atttggaaga 30240 tcacgaggaa gatgagcatg actacgcaga tgcatgccag gcatcagagg cagaagcgct 30300 accggtggcc ctaaaacagt atgcagactc ccacaccacc cccaaccttc ctccaccttc 30360 ccagaagcca agtttcctgg gggaaaatga aactctgcct ctttccatac tagctctgac 30420 atctgttgct attttggccg ctctgctggt gcttctatgc tctatatgct acctgatctg 30480 ctgcagaaag aaaaaatctc acggccatgc tcaccagccc ctcatgcact tcccttaccc 30540 tccagagctg ggcgaccaca aactttaagt ctgcagtagc tatctgccca tcccttgtca 30600 gtcgacagcg atgagcccca ctaatctaac agcctctgga cttacaacat tgtctcttaa 30660 tgagaccacc gctcctcaag acctgtacga tggtgtctcc gcgctggtta accagtggga 30720 tcacctgggc atatggtggc tcctcatagg agcagtgacc ctgtgcctaa tcctggtctg 30780 gatcatctgc tgcatcaaaa gcagaagacc caggcggcgg cccatctaca ggcccttcgt 30840 catcacacct gaagataatg atgatgatga caccacctcc aggctgcaga gcctaaagca 30900 gctactcttc tcttttacag catggtaaat tgaatcatgc cccgcatttt catctacttg 30960 cttctccttc cactttttct gggctcctct acattggcca ctgtgtccca catcgaggta 31020 gactgcctca cgcccttcac agtctacctg cttttcggct ttgtcatctg cacctttgtc 31080 tgcagcgtta tcactgtagt gatctgcttc atacagtgca tcgactacat ctgtgtgcgg 31140 gtggcctact ttagacacca cccccagtat cgcaacaggg acatagcggc tctcctaaga 31200 cttgtttaaa tcatggccaa attacctgtg attggtcttc tgattatctg ctgcgtccta 31260 gccgcgattg ggactcaacc taataccacc accagcgctc ccagaaagag acatgtatcc 31320 tgcagcttca agcgtccctg gaatataccc caatgcttta ctgatgaacc tgaaatctct 31380 ttggcttggt acttcagcgt caccgccctt ctcatcttct gcagtacggt tattgctctt 31440 gccatctacc cttcccttaa cctgggctgg aatgctgtca actctatgga atatcccacc 31500 ttcccagaac cagacctgcc agacctggtt gttctaaacg cgtttcctcc tcctccagtt 31560 caaaatcagt ttcgccctcc gtcccctacg cccactgagg tcagctactt taatctaaca 31620 ggcggagatg actgaaaacc tagacctaga aatggacggt ctctgcagcg agcaacgcac 31680 actagagagg cgccggcaaa aagcagagct cgagcgtctt aaacaagagc tccaagacgc 31740 cgtggccata caccagtgca aaaaagggct cttctgtctg gtaaaacagg ccacgctcac 31800 ctatgaaaaa acaggtgaca cccaccgcct aggatacaag ctgcccacac agcgccaaaa 31860 gtttgccctt atgataggtg aacaacccat caccgtcacc cagcactccg tggagacaga 31920 aggctgcatt catgctccct gcaggggcgc tgactgcctc tacaccttga tcaaaaccct 31980 ctgcggtctc agagacctta tccctttcaa ttgatcataa ctgtaatcaa taaaaaatca 32040 cttacttgaa atctgatagc aagactctgt ccaatttttt cagcaacact tccttcccct 32100 cctcccaact ctggtactct aggcgcctcc tagctgcaaa cttcctccac agtctgaagg 32160 gaatgtcaga ttcctcctcc tgtccctccg cacccacgat cttcatgttg ttacagatga 32220 aacgcgcgag atcgtctgac gagaccttca accccgtgta cccctacgat accgagatcg 32280 ctccgacttc tgtccctttc cttacccctc cctttgtatc atccgcagga atgcaagaaa 32340 atccagctgg ggtgctgtcc ctgcacctgt cagagcccct taccacccac aatggggccc 32400 tgactctaaa aatggggggc ggcctgaccc tggacaagga agggaatctc acttcccaaa 32460 acatcaccag tgtcgatccc cctctcaaaa aaagcaagaa caacatcagc cttcagaccg 32520 ccgcacccct cgccgtcagc tccggggccc taaccctttt tgccactccc cccctagcgg 32580 tcagtggcga caaccttact gtgcagtctc aggcccctct tactttggaa gactcaaaac 32640 taactctggc caccaaagga cccctaactg tgtccgaagg caaacttgtc ctagaaacag 32700 agcctcccct gcatgcaagt gacagcagta gcctgggcct tagcgtcacg gccccactta 32760 gcattaacaa tgacagccta ggactagaca tgcaagcgcc catcagctct cgagatggaa 32820 aactggctct aacagtggcg gcccccctaa ctgtggccga gggtatcaat gctttggcag 32880 tagccacagg taatggtatt ggactaaatg aaaccaacac acacctgcag gcaaaactgg 32940 tcgcgcccct aggctttgat accaacggca acattaagct aagcgtcgca ggaggcatga 33000 ggctaaacaa taacacactg atactagatg taaactaccc atttgaggct caaggccaac 33060 tgagcctaag agtgggctcg ggcccactat atgtagattc tagtagtcat aacctaacca 33120 ttagatgcct taggggattg tatgtaacat cttctaacaa ccaaaacggt ctagaggcca 33180 acattaaact aacaaaaggc cttgtgtatg acggaaatgc catagcagtt aatgttggca 33240 aagggctgga atacagccct actggcacaa cagaaaaacc tatacagact aaaataggtc 33300 taggcatgga gtatgacact gagggagcca tgatgacaaa actaggctct ggactaagct 33360 ttgacaattc aggagccatt gtggtgggaa acaaaaatga tgacaggctt actttgtgga 33420 ccacaccgga cccatcgccc aactgtcaga tttactctga aaaagatgct aaactaacct 33480 tggtactgac taaatgtggc agtcaggttg taggcacagt atctattgcc gctcttaaag 33540 gtagccttgt gccaatcact agtgcaatca gtgtggttca gatataccta aggtttgatg 33600 aaaatggggt gctgatgagt aactcttcac ttaatggcga atactggaat tttagaaacg 33660 gagactcaac taatggcaca ccatatacaa acgcagtggg ttttatgcct aatctactgg 33720 cctatcctaa aggtcaaact acaactgcaa aaagtaacat tgtcagccag gtctacatga 33780 acggggacga tactaaaccc atgacattta caatcaactt caatggcctt agtgaaacag 33840 gggatacccc tgtcagtaaa tattccatga cattctcatg gaggtggcca aatggaagct 33900 acatagggca caattttgta acaaactcct ttactttctc ctacatcgcc caagaataaa 33960 gaaagcacag agatgcttgt ttttgatttc aaaattgtgt gcttttattt attttcaagc 34020 ttacagtatt tccagtagtc attagaatag agcttaatta aactgcatga gaacccttcc 34080 acatagctta aattatcacc agtgcaaatg gaaaaaaatc aacatacctt tttatccaga 34140 tatcaaagaa ctctagtggt cagttttccc ccaccctccc agctcacaga atacacagtc 34200 ctttcccccc ggctggcttt aaacaacact atctcattgg taacagacat atttttaggt 34260 gtaataatcc acacggtctc ttggcgggcc aaacgctggt ctgtgatgtt aataaactcc 34320 ccaggcagct ctttcaagtt cacgtcgctg tccaactgct gaagcgctcg cggctccgac 34380 tgcgcctcta gcggaggcaa cggcagcacc cgatccttga tctataaagg agtagagtca 34440 taatccccca taagaatagg gcggtgatgc agcaacaagg cgcgcagcaa ctcctgccgc 34500 cgcctctccg tacgacagga atgcaacggg gtggtggtct cctccgcgat aatccgcacc 34560 gctcgcagca tcagcatcct cgtcctccgg gcacagcagc gcatcctgat ctcactgaga 34620 tcggcgcagt aagtgcagca caacaccaag atgttattta agatcccaca gtgcaaagca 34680 ctgtacccaa agctcatggc gggaaggaca gcccccacgt gaccatcgta ccagatcctc 34740 aggtaaatca aatgacgacc tctcataaac acgctggaca tatacatcac ctccttgggc 34800 atgagctgat tcaccacctc tcgataccac aggcatcgct gattaattaa agacccctcg 34860 agcaccatcc tgaaccagga agccagcacc tgaccccccg ccaggcactg cagggacccc 34920 ggtgaatcgc agtggcagtg aagactccag cgctcgtagc cgtgaaccat agagctggtc 34980 attatatcca cattggcaca acacagacac actttcatac actttttcat gattagcagc 35040 tcctctctag tcaagaccat atcccaagga atcacccact cttgaatcaa ggtaaatccc 35100 acacagcagg gcaggcctct cacataactc acgttatgca tagtgagcgt gtcgcaatct 35160 ggaaataccg gatgatcttc catcaccgaa gcccgggtct ccgtctcaaa gggaggtaaa 35220 cggtccctcg tgtagggaca gtggcgggat aatcgagatc gtgttgaacg tagagtcatg 35280 ccaaagggaa cagcggacgt actcatattt cctccagcag aaccaagtgc gcgcgtggca 35340 gctatccctg cgtcttctgt ctcgccgcct gccccgctcg gtgtagtagt tgtaatacag 35400 ccactccctc agaccgtcaa ggcgctccct ggcgtccgga tctataacaa caccgtcctg 35460 cagcgccgcc ctgatgacat ccaccaccgt agagtatgcc aagcccagcc acgaaatgca 35520 ctcactttga cagcgagaga taggaggagc gggaagagat ggaagaacca tgatagtaaa 35580 agaactttta ttccaatcga tcctctacaa tgtcaaagtg tagatctatc agatggcact 35640 ggtctcctcc gctgagtcga tcaaaaataa cagctaaacc acaaacaaca cgattggtca 35700 aatgctgcac aagggcttgc agcataaaat cgcctcgaaa gtccaccgca agcataacat 35760 caaagccacc gcccctatca tgatctatga taaaaacccc acagctatcc accagaccca 35820 tatagttttc atctctccat cgtgaaaaaa tatttacaag ctcctccttt aaatcacctc 35880 caaccaattc aaaaagttga gccagaccgc cctccacctt cattttcagc atgcgcatca 35940 tgattgcaaa aattcaggct cctcagacac ctgtataaga ttgagaagcg gaacgttaac 36000 atcaatgttt cgctcgcgaa gatcgcgcct cagtgcaagc atgatataat cccacaggtc 36060 ggagcggatc agcgaggaca tctccccgcc aggaaccaac tcaacggagc ctatgctgat 36120 tataatacgc atattcgggg ctatgctaac cagcacggcc cccaaatagg cgtactgcat 36180 aggcggcgac aaaaagtgaa cagtttgggt taaaaaatca ggcaaacact cgcgcaaaaa 36240 agcaagaaca tcataaccat gctcatgcaa atagatgcaa gtaagctcag gaacgaccac 36300 agaaaaatgc acaatttttc tctcaaacat gactgcgagc cctgcaaaaa ataaaaaaga 36360 aacattacac aagagtagcc tgtcttacaa tgggatagac tactctaacc aacataagac 36420 gggccacgac atcgcccgcg tggccataaa aaaaattatc cgtgtgatta aaaagaagca 36480 cagatagctg gccagtcata tccggagtca tcacgtgcga acccgtgtag acccccgggt 36540 tggacacatc ggccaaacaa agaaagcggc caatgtatcc cggaggaatg ataacactaa 36600 gacgaagata caacagaata accccatggg ggggaataac aaagttagta ggtgaataaa 36660 aacgataaac acccgaaact ccctcctgcg taggcaaaat agcgccctcc ccttccaaaa 36720 caacatacag cgcttccaca gcagccatga caaaagactc aaaacactca aaagactcag 36780 tcttaccagg aaaataaaag cactctcaca gcaccagcac taatcagagt gtgaagaggg 36840 ccaagtgccg aacgagtata tataggaatt aaaaatgacg taaatgtgta aaggtcaaaa 36900 aacgcccaga aaaatacaca gaccaacgcc cgaaacgaaa acccgcgaaa aaatacccag 36960 aagttcctca acaaccgcca cttccgcttt cccacgatac gtcacttcct caaaaatagc 37020 aaactacatt tcccacatgt acaaaaccaa aacccctccc cttgtcaccg cccacaactt 37080 acataatcac aaacgtcaaa gcctacgtca cccgccccgc ctcgccccgc ccacctcatt 37140 atcatattgg cctcaatcca aaataaggta tattattgat gatg 37184 <210> 3 <211> 37169 <212> DNA <213> Great Ape Adenovirus <400> 3 catcatcaat aatatacctt attttggatt gtggccaata tgataatgag gtgggcgggg 60 cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgc ggaagtgtgg catttgcaag 120 tgggaggagc tcacatgtaa gcttccgtcg cggaaaatgt gacgttttta atgagcgccg 180 cctacctccg gaagtgccaa ttttcgcgcg cttttcaccg gatatcgtag taattttggg 240 cgggaccatg taagatttgg ccattttcgc gcgaaaagtg aaacggggaa gtgaaaactg 300 aataataggg cgttagtcat agcgcgtaat atttaccgag ggccgaggga ctttgaccga 360 ttacgtggag gactcgccca ggtgtttttt acgtgaattt ccgcgttccg ggtcaaagtc 420 tccgttttta ttgtcaccgt catctgacgc ggagggtatt taaacccgct gcgctcctaa 480 agaggccact cttgagtgcc agcgagaaga gttttctcct ccgctccgtt tcggcgatcg 540 aaaaatgaga cacttagcct gcactccggg tcttttgtcc ggccgggcgg cgtccgagct 600 tttggacgct ttgctcaatg aggttctgag cgatgatttt ccgtctacta cccactttag 660 cccacctact cttcacgaac tgtacgatct ggatgtactg gtggatgtga acgatcccaa 720 cgaggaggcg gtttctacgt tttttcccga gtctgcgctt ttggccgccc aggagggatt 780 tgacctacac actccgccgc tgcctatttt agagtctccg ctgccggagc ccagtggtat 840 accttatatg cctgaactgc ttcccgaagt ggtagacctg acctgccacg agccgggctt 900 tccgcccagc gacgatgagg gtgagccttt tgctttagac tatgctgaga tacctgggct 960 cggttgcagg tcttgtgcat atcatcagag ggttaccgga gaccccgagg ttaagtgttc 1020 gctgtgctat atgaggctga cctcttcctt tatctacagt aagttttttg tgtaggtggg 1080 ctttttgggt aggtgggttt tgtggcagga caggtgtaaa tgttgcttgt gttttttgta 1140 cctgcaggtc cggtgtccga gccagacccg gagcccgacc gcgatcccga gccggatccc 1200 gagcctcctc gcagggcaag gaaattacct tccattttgt gcaagcctaa gacacctgtg 1260 aggaccagcg aggcggacag cactgactct ggcacttcta cctctcctcc tgaaattcac 1320 ccagtggttc ctttgggtat acataaacct gttgctatta gagtttgcgg gcgacgccct 1380 gcagtagagt gcattgagga cttgcttaac gatcccgagg gacctttgga cttgagcatt 1440 aaacgcccta ggcaataaac cccacctaag taataaaccc cacctaagta ataaacttta 1500 ccgcccttgg ttattgagat gacgcccaat gtttgctttt gaatgacttc atgtgtataa 1560 taaaagtgag tgtggtcata ggtctcttgt ttgtctgggc ggggcttaag ggtatataag 1620 tttctcgggg ctaaacttgg ttacacttga ccccaatgga ggcgtggggg tgcttggagg 1680 agtttgcgga cgtgcgccgt ttgctggacg agagctctag caatacctat agtatttgga 1740 ggtatctgtg gggctctact caggccaagt tggtctccag aattaagcag gattacaagt 1800 gcgattttga agagcttttt agttcctgtg gtgagctttt gcaatccttg aatctgggcc 1860 accaggctat cttccaggaa aaggttctct cgactttgga tttttccact cccgggcgca 1920 ccgccgcttg tgtggctttt gtgtcttttg tgcaagataa atggagcggg gagacccacc 1980 tgagtcacgg ctacgtgctg gatttcatgg cgatggctct ttggagggct tacaacaaat 2040 ggaagattca gaaggaactg tacggttccg ccctacgtcg tccacttctg cagcggcagg 2100 ggctgatgtt tcccgaccat cgccagcatc agaatctgga agacgagtcg gaggagcgag 2160 cggagaagat cagcttgaga gccggcctgg accctcctca ggaggaatga atctcccgca 2220 ggtggttgac ctgtttcccg aactgagacg ggtcctgact atcagggaag atggtcagtt 2280 tgtgaagaag ctgaagaggg atcggggtga gggagatgat gaggcggcta gcaatttagc 2340 ttttagtctg ataacccgcc accgaccgga atgtattacc tatcagcaga ttaaggagag 2400 ttgtgccaac gagctggatc ttttgggtca gaagtatagc atagaacagc ttaccactta 2460 ctggcttcag cccggggatg attgggaaga ggcgatcagg gtgtatgcaa aggtggccct 2520 gcggcccgat tgcaagtata agattactaa gttggttaat attagaaact gctgctatat 2580 ttctgggaac ggggccgaag tggagataga tactgaggac agggtggcta ttaggtgttg 2640 catgataaac atgtggcccg ggatactggg gatggatggg gtgatattta tgaatgtaag 2700 gttcacgggc cccaacttta atggtacggt gttcatgggc aacaccaact tgctcctgca 2760 tggtgcgagt ttctatgggt ttaacaacac ctgtatagag gcctggaccg atgtaaaggt 2820 tcgaggttgt tccttttata gctgttggaa ggcggtggtg tgtcgcccta aaagcagggg 2880 ttctgtgaag aaatgcttgt ttgaaaggtg caccctaggt atcctttctg agggcaactc 2940 cagggtgcgc cataatgtgg cttcgaactg cggttgcttc atgcaagtga agggggtgag 3000 cgttatcaag cataactcgg tctgtggaaa ctgcgaggat cgcgcctctc agatgctgac 3060 ctgctttgat ggcaactgtc acctgttgaa gaccattcat ataagcagtc accccagaaa 3120 ggcctggccc gtgtttgagc ataacattct gacccgctgt tccttgcatc tgggggtcag 3180 gaggggtatg ttcctgcctt accagtgtaa cttcagccac actaaaatcc tgctggaacc 3240 cgagtgcatg actaaggtca gcctgaatgg tgtgtttgat gtgagtctga agatttggaa 3300 ggtgctgagg tatgatgaga ccaggaccag gtgccgaccc tgcgagtgcg gcggcaagca 3360 catgagaaat cagcctgtga tgttggatgt gaccgaggag cttaggcctg accatctggt 3420 gctggcctgc accagggccg agtttgggtc tagcgatgag gataccgatt gaggtgggta 3480 aggtgggcgt ggctagcagg gtgggcgtgt ataaattggg ggtctaaggg gtctctctgt 3540 ttgtcttgca acagccgccg ccatgagcga caccggcaac agctttgatg gaagcatctt 3600 tagcccctat ctgacagtgc gcatgcctca ctgggccgga gtgcgtcaga atgtgatggg 3660 ttccaacgtg gatggacgtc ccgttctgcc ttcaaattcg tctacgatgg cctacgcgac 3720 cgtgggagga actccgttgg acgccgcgac ctccgccgcc gcctccgccg ccgccgcgac 3780 cgcgcgcagc atggctacgg acctttacag ctctttggtg gcgagcagcg cggcctctcg 3840 cgcgtctgct cgggatgaga aactgactgc tctgctgctt aaactggaag acttgacccg 3900 ggagctgggt caactgaccc agcaggtctc cagcttgcgt gagagcagcc ttgcctcccc 3960 ctaatggccc ataatataaa taaaagccag tctgtttgga ttaagcaagt gtatgttctt 4020 tatttaactc tccgcgcgcg gtaagcccgg gaccagcggt ctcggtcgtt tagggtgcgg 4080 tggattcttt ccaacacgtg gtacaggtgg ctctggatgt ttagatacat gggcatgagt 4140 ccatccctgg ggtggaggta gcaccactgc agagcttcgt gctcgggggt ggtgttgtat 4200 atgatccagt cgtagcagga gcgctgggcg tggtgctgaa aaatgtcctt aagcaagagg 4260 cttatagcta gggggaggcc cttggtgtaa gtgtttacaa atctgctcag ctgggagggg 4320 tgcatccggg gggatatgat gtgcatcttg gactggattt ttaggttggc tatgttccca 4380 cccagatccc ttctgggatt catgttgtgc aggaccacca gcacggtata tccagtgcac 4440 ttgggaaatt tatcgtggag cttagacggg aatgcatgga agaacttgga gacgcccttg 4500 tggcctccca gattttccat acattcgtcc atgatgatgg caatgggccc gtgggaagct 4560 gcctgagcaa aaacgtttct gggatcgctc acatcgtagt tatgttccag ggtgaggtca 4620 tcataggaca tctttacgaa tcgggggcgg agggtcccgg actgggggat gatggtaccc 4680 tcgggccccg gggcgtagtt cccctcacag atctgcatct cccaggcttt catttcagag 4740 ggagggatca tatccacctg cggggcgatg aaaaagacag tttctggcgc aggggagatt 4800 aactgggatg agagcaggtt tctgagcagc tgtgactttc cacagccggt gggcccatat 4860 atcacgccta tcaccggctg cagctggtag ttaagagagc tgcagctgcc gtcctcccgg 4920 agcagggggg ccacctcgtt gagcatatcc ctgacgtgga tgttttccct gaccagttcc 4980 gccagaaggc gctcgccgcc cagcgaaagc agctcttgca aggaagcaaa atttttcagc 5040 ggtttcaggc catcggccgt gggcatgttt ttcagcgtct gggtcagcag ctccagcctg 5100 tcccagagct cggtgatgtg ctctacggca tctcgatcca gcagatctcc tcgtttcgcg 5160 ggttggggcg gctttcgctg tagggcacca gccgatgggc gtccagcggg gccagagtca 5220 tgtccttcca tgggcgcaga gtcctcgtca gggtggtctg ggtcacggtg aaggggtgcg 5280 ctccgggttg ggcgctggcc agggtgcgct tgaggctggt tctgctggtg ctgaatcgct 5340 gccgctcttc gccctgcgcg tcggccaggt agcatttgac catggtctcg tagtcgagac 5400 cctcggcggc gtgccccttg gcgcggagct ttcccttgga ggtggcgccg cacgaggggc 5460 actgcaggct cttcagggcg tagagcttgg gagcgagaaa cacggactct ggggagtagg 5520 cgtccgcgcc gcaggccgag cagaccgtct cgcattccac cagccaagtg agttccgggc 5580 ggtcagggtc aaaaaccagg ctgcccccat gctttttgat gcgtttctta cctcggctct 5640 ccatgaggcg gtgtcccttc tcggtgacga agaggctgtc cgtgtccccg tagaccgatt 5700 tcaggggcct gtcttccagc ggagtgcctc tgtcctcctc gtagagaaac tctgaccact 5760 ctgagacaaa ggcccgtgtc caggccagga cgaaggaggc cacgtgggag gggtagcggt 5820 cgttgtccac tagcgggtcc accttctcca gggtgtgcag gcacatgtcc ccctcctccg 5880 cgtccagaaa agtgattggc ttgtaggtgt aggacacgtg accgggggtt cccgacgggg 5940 gggtataaaa gggggtgggt gccctttcat cttcactctc ttccgcatcg ctgtctgcga 6000 gagccagctg ctggggtaag tattcccttt cgaaggcggg catgacctca gcgctcaggt 6060 tgtcagtttc taaaaatgag gaagatttga tgttcacctg tccggaggtg atacctttga 6120 gggtacctgg gtctatctgg tcagaaaaca ctattttttt gttatcaagc ttggtggcga 6180 acgacccgta gagggcgttg gagagcagct tggcgatgga gcgcagggtc tggtttttgt 6240 cgcggtcggc tcgctccttg gccgcgatgt tgagttgcac gtactcgcgg gccacgcact 6300 tccactcggg gaagacggtg gtgcgctcgt ctgggatcag gcgcaccctc cagccgcggt 6360 tgtgcagggt gaccatgtcg acgctggtgg cgacctcacc gcgcaggcgc tcgttggtcc 6420 agcagaggcg gccgcccttg cgcgagcaga aggggggtag ggggtccagc tggtcctcgt 6480 tcggggggtc cgcgtcgatg gtaaagaccc cggggagcag acgcgggtca aagtagtcga 6540 tcttgcaagc ttgcatgtcc agagcccgct gccattcgcg ggcggcgagc gcgcgctcgt 6600 aggggttgag gggcgggccc cagggcatgg ggtgggtgag cgcagaggcg tacatgccgc 6660 agatgtcata cacgtacagg ggttccctga ggatgccgag gtaggtgggg tagcagcgcc 6720 ccccgcggat gctggcgcgc acgtagtcat agagttcgtg ggagggggcc agcatgttgg 6780 gcccgaggtt ggtgcgctgg gggcgctcgg cgcggaagac gatctgcctg aagatggcgt 6840 gggagttgga ggagatggtg ggccgctgga agacgttgaa gcttgcttct tgcaagccca 6900 cggagtccct gacgaaggag gcgtaggact cgcgcagctt gtgcaccagc tcggcggtga 6960 cctggacgtc gagcgcacag tagtcgaggg tctcacggat gatgtcatac ttatcctccc 7020 ccttcttttt ccacagctcg cggttgagga cgaactcttc gcggtctttc cagtactctt 7080 ggaggggaaa cccgtccgtg tccgaacggt aagagcctag catgtagaac tggttgacgg 7140 cctggtaggg gcagcagccc ttctccacgg gcagcgcgta ggcctgcgcc gccttgcgga 7200 gggaggtgtg ggtgagggcg aaagtgtccc tgaccatgac tttgaggtat tgatgtctga 7260 agtctgtgtc atcgcagccg ccctgttccc acagggtgta gtccgtgcgc tttttggagc 7320 gcgggttggg cagggagaag gtgaggtcat tgaagaggat cttccccgct cgaggcatga 7380 agtttctggt gatgcgaaag ggccctggga ccgaggagcg gttgttgatg acctgggcgg 7440 ccaggacgat ctcgtcaaag ccgtttatgt tgtggcccac gatgtagagc tccaggaagc 7500 ggggctggcc cttgatggag gggagctttt taagttcctc gtaggtgagc tcctcgggcg 7560 attccaggcc gtgctcctcc agggcccagt cttgcaagtg agggttggcc gccaggaagg 7620 atcgccagag gtcgcgggcc atgagggtct gcaggcggtc gcggaaggtt ctgaactgtc 7680 gccccacggc catcttttcg ggggtgatgc aatagaaggt gagggggtct ttctcccagg 7740 ggtcccatct gagctctcgg gcgaggtcgc gtgcggcggc gaccagagcc tcgtcgcccc 7800 ccagtttcat gaccagcatg aagggcacga gctgcttgcc aaaggctccc atccaagtgt 7860 aggtctctac atcgtaggtg acaaagaggc gctccgtgcg aggatgagag ccgatcggga 7920 agaactggat ctcccgccac cagttggagg attggctgtt gatgtggtga aagtagaagt 7980 cccgtctgcg ggccgagcac tcgtgctggc ttttgtaaaa gcgaccgcag tactggcagc 8040 gctgcacggg ttgtatatct tgcacgaggt gaacctggcg acctctgacg aggaagcgca 8100 gcgggaatct aagtcccccg cctggggtcc cgtgtggctg gtggtcttct actttggttg 8160 tctggccgcc agcatctgtc tcctggaggg cgatggtgga acagaccacc acgccgcgag 8220 agccgcaggt ccagatctcg gcgctcggcg ggcggagttt gatgacgaca tcgcgcacat 8280 tggagctgtc catggtctcc agctcccgcg gcggcaggtc agccgggagt tcctggaggt 8340 ttacctcgca gagacgggtc aacgcacggg cagtgttaag atggtatctg atttcaaggg 8400 gcgtgttggc ggcggagtcg atggcttgca ggaggccgca gccccggggg gccacgatgg 8460 ttccccgtgg ggcgcgaggg gaggcggaag ctgggggtgt gttcagaagc ggtgacgcgg 8520 gcgggccccc ggaggtaggg ggggttccgg ccccacaggc atgggcggca ggggcacgtc 8580 ttcgccgcgc gcgggcaggg gctggtgctg gctccgaaga gcgcttgcgt gcgcgacgac 8640 gcgacggttg gtgtcctgta tctggcgcct ctgagtgaag accacgggtc ccgtgacctt 8700 gaacctgaaa gagagttcga cagaatcaat ctcggcatcg ttgacagcgg cctggcgcag 8760 gatctcctgc acgtcgcccg agttgtcctg gtaggcgatc tctgccatga actgctcgat 8820 ctcttcctcc tggagatctc ctcgtccggc gcgctccacg gtggccgcca ggtcgttgga 8880 gatgcgaccc atgagctgcg agaaggcgtt gagtccgccc tcgttccaga cccggctgta 8940 gaccacgccc ccctcggcgt cgcgggcgcg catgaccacc tgggccaggt tgagctccac 9000 gtgtcgcgtg aagacggcgt agttgcgcag gcgctggaaa aggtagttca gggtggtggc 9060 ggtgtgctcg gcgacaaaga agtacatgac ccagcgccgc aacgtggatt cattgatgtc 9120 ccccaaggcc tccaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 9180 ggagttgcga gcggacacgg tcaactcctc ctccagaaga cggatgagct cggcgacagt 9240 gtcgcgcacc tcgcgctcga aggccacggg gggcgcttct tcctcttcca cctcttcttc 9300 catgattgct tcttcttctt cctcagccgg gacgggaggg ggcggcggcg ggggaggggc 9360 gcggcggcgg cggcggcgca ccgggaggcg gtcgatgaag cgctcgatca tctccccccg 9420 catgcggcgc atggtctcgg tgacggcgcg gccgttctcc cgggggcgca gctcgaagac 9480 gccgcctttc atctcgccgc ggggcgggcg gccgtgaggt agcgagacgg cgctgactat 9540 gcatcttaac aattgctgtg taggtacgcc gccaagggac ctgattgagt ccagatccac 9600 cggatccgaa aacctttgga ggaaagcgtc tatccagtcg cagtcgcaag gtaggctgag 9660 caccgtggcg ggcgggggcg ggtcgggaga gttcctggcg gagatgctgc tgatgatgta 9720 attaaagtag gcggtcttga gaaggcggat ggtggacagg agcaccatgt ctttgggtcc 9780 ggcctgttgg atgcggaggc ggtcggccat gccccaggcc tcgttctgac accggcgcag 9840 gtctttgtag tagtcttgca tgagtctttc caccggcacc tcttctcctt cctcttctcc 9900 atctcgccgg tggtttctcg cgccgcccat gcgcgtgacc ccaaagcccc tgagcggctg 9960 cagcagggcc aggtcggcga ccacgcgctc ggccaagatg gcctgctgta cctgagtgag 10020 ggtcctctcg aagtcatcca tgtccacgaa gcggtggtag gcgcccgtgt tgatggtgta 10080 ggtgcagttg gccatgacgg accagttgac ggtctggtgt cccggctgcg agagctccgt 10140 gtaccgcagg cgcgagaagg cgcgggaatc gaacacgtag tcgttgcaag tccgcaccag 10200 atactggtag cccaccagga agtgcggcgg aggttggcga tagaggggcc agcgctgggt 10260 ggcgggggcg ccgggcgcca ggtcttccag catgaggcgg tggtatccgt agatgtacct 10320 ggacatccag gtgatgccgg cggcggtggt ggtggcgcgc gcgtagtcgc ggacccggtt 10380 ccagatgttt cgcaggggcg agaagtgttc catggtcggc acgctctggc cggtgaggcg 10440 cgcgcagtcg ttgacgctct atacacacac aaaaacgaaa gcgtttacag ggctttcgtt 10500 ctgtagcctg gaggaaagta aatgggttgg gttgcggtgt gccccggttc gagaccaagc 10560 tgagctcggc cggctgaagc cgcagctaac gtggtattgg cagtcccgtc tcgacccagg 10620 ccctgtatcc tccaggatac ggtcgagagc ccttttgctt tcttggccaa gcgcccgtgg 10680 cgcgatctgg gatagatggt cgcgatgaga ggacaaaagc ggctcgcttc cgtagtctgg 10740 agaaacaatc gccagggttg cgttgcggcg taccccggtt cgagccccta tggcggcttg 10800 gatcggccgg aaccgcggct aacgtgggct gtggcagccc cgtcctcagg accccgccag 10860 ccgacttctc cagttacggg agcgagcccc ttttgttttt tattttttag atgcatcccg 10920 tgctgcggca gatgcgcccc tcgccccggc ccgatcagca gcagcaacag caggcatgca 10980 gacccccctc tcctctcccc gccccggtca ccacggccgc ggcggccgtg tccggcgcgg 11040 ggggtgcgct ggagtcagat gagccaccgc ggcggcgacc taggcagtat ctggacttgg 11100 aagagggcga gggactggcg cggctggggg cgagctcccc agagcgtcac ccgcgggtgc 11160 agttgaaaag ggacgcgcgc gaggcgtacc tgccgcggca aaacctgttt cgcgaccgcg 11220 ggggcgagga gcccgaggag atgcgagact gcaggttcca agcagggcgc gagctgcgcc 11280 gcggcttgga cagagagcgc ttgctgcgcg aggaggactt tgagcccgac acgcagacgg 11340 gcatcagccc cgcgcgcgcg cacgtggccg cggccgacct ggtgaccgcc tacgagcaga 11400 cggtgaacca ggagcgcaac ttccaaaaaa gcttcaacaa ccacgtgcgc acgctggtgg 11460 cgcgcgagga ggtgaccctg ggtctcatgc atctgtggga cctggtggag gcgatcgtgc 11520 agaaccccag cagcaagccc ctgaccgcgc agctgttcct ggtggtgcag cacagcaggg 11580 acaacgatgc cttcagggag gcgctgctga acatcaccga gccggagggg cgctggctcc 11640 tggacctgat aaacatcctg cagagcatag tggtgcagga gcgcagcctg agcctggccg 11700 agaaggtggc ggccattaac tattctatgc tgagcctggg caagttctac gcccgcaaga 11760 tctacaagac cccctacgtg cccatagaca aggaggtgaa gatagacagc ttctacatgc 11820 gcatggcgct aaaggtgctg accctgagcg acgacctggg agtgtaccgc aacgagcgca 11880 tccacaaggc cgtgagcgcc agccggcggc gcgagctgag cgaccgcgag ctgatgcaca 11940 gtctgcaacg cgcgctgacc ggcgcgggcg agggcgacag ggaggtcgag tcctacttcg 12000 acatgggggc cgacctgcac tggcagccga gccgccgcgc cctggaggcg gcgggggcgt 12060 atggcggccc cctggcggcc gatggcgagg aagaggagga ctatgagcta gaggagggcg 12120 agtacctgga ggactgacct ggctggtggt gttttggtat agatgcaaga tccgaacgtg 12180 gcggacccgg cggtccgggc ggcgctgcag agccagccgt ccggcattaa ctcctctgac 12240 gactgggccg cggccatggg tcgcatcatg gccctgaccg cgcgcaaccc cgaggccttc 12300 aggcagcagc ctcaggctaa ccggctggcg gccatcttgg aagcggtagt gcccgcgcgc 12360 tccaacccca cccacgagaa ggtgctggcc atagtcaacg cgctggcgga gagcagggcc 12420 atccgggcgg acgaggccgg actggtgtac gatgcgctgc tgcagcgggt ggcgcggtac 12480 aacagcggca acgtgcaaac caacctggac cgcctggtga cggacgtgcg cgaggccgtg 12540 gcgcagcgcg agcgcttgca tcaggacggt aacctgggct cgctggtggc gctaaacgcc 12600 ttcctcagca cccagccggc caacgtaccg cgggggcagg aggactacac caacttcttg 12660 agcgcgctgc ggctgatggt gaccgaggtc cctcagagcg aagtgtacca gtcggggccc 12720 gactacttct tccagaccag cagacagggc ttgcaaaccg tgaacctgag ccaggctttc 12780 aagaacctgc gggggctgtg gggagtgaag gcgcccaccg gcgaccgggc tacggtgtcc 12840 agcctgctaa cccccaactc gcgcctgctg ctgctgctga tcgcgccctt cacggacagc 12900 gggagcgtct cgcgggagac ctatctgggc cacctgctga cgctgtaccg cgaggccatc 12960 gggcaggcgc aggtggacga gcacaccttc caggagatca ccagcgtgag ccacgcgctg 13020 gggcaggagg acacgggcag cctgcaggcg accctgaact acctgctgac caacaggcgg 13080 cagaagattc ccacgctgca cagcctgacc caggaggagg agcgcatctt gcgctacgtg 13140 cagcagagcg tgagcctgaa cctgatgcgc gacggcgtga cgcccagcgt ggcgctggac 13200 atgaccgcgc gcaacatgga accgggcatg tacgcttccc agcggccgtt catcaaccgc 13260 ctgatggact acttgcatcg ggcggcggcc gtgaaccccg agtacttcac caatgccatt 13320 ctgaatcccc actggatgcc ccctccgggt ttctacaacg gggactttga ggtgcccgag 13380 gtcaacgacg ggttcctctg ggatgacatg gatgacagtg tgttctcccc caacccgctg 13440 cgcgccgcgt ctctgcgatt gaaggagggc tctgacaggg aaggaccgag gagtttggcc 13500 tcctccctgg ctctgggggc ggtgggcgcc acgggcgcgg cggcgcgggg cagcagcccc 13560 ttccccagcc tggcggactc tctgaatagc gggcgggtga gcaggccccg cttgctaggc 13620 gaggaggagt atctgaacaa ctccctgcta cagcccgtga gggacaaaaa cgctcagcgg 13680 cagcagtttc ccaacaacgg gatagagagc ctggtggaca agatgtccag atggaagacg 13740 tatgcgcagg agtacaagga gtgggaggac cgacagccgc ggcccctgcc gccccctaga 13800 cagcgctggc agcggcgtgc gtccaaccgc cgctggaggc aggggcccga ggacgatgat 13860 gactctgcag atgacagcag cgtgttggat ctgggcggga gcgggaaccc cttttcgcac 13920 ctgcgcccac gcctgggcaa gatgttttaa aagagaaaaa taaaaactca ccaaggccat 13980 ggcgacgagc gttggttttt ttgttccctt ccttagtatg cggcgcgcgg cgatgttcga 14040 ggaggggcct cccccctctt acgagagcgc gatgggaatt tctcctgcgg cgcccctgca 14100 gcctccctac gtgcctcctc ggtacctgca acctacaggg gggagaaata gcatctgtta 14160 ctctgagctg cagcccctgt acgataccac cagactgtac ctggtggaca acaagtccgc 14220 ggacgtggcc tccctgaact accagaacga ccacagcgat tttttgacca cggtgatcca 14280 aaacaacgac ttcaccccaa ccgaggccag tacccagacc ataaacctgg acaacaggtc 14340 gaactggggc ggcgacctga agactatcct gcacaccaat atgcccaacg tgaacgagtt 14400 catgttcacc aactctttta aggcgcgggt gatggtggcg cgcgagcagg gggaggcgaa 14460 gtacgagtgg gtggacttca cgctgcccga gggcaactat tcagagacca tgactctcga 14520 cctgatgaac aatgcgatcg tggaacacta tctgaaagtg ggcaggcaga acggggtgaa 14580 ggagagcgat atcggggtca agtttgacac cagaaacttt cgtctgggct gggaccccgt 14640 gaccgggctg gtcatgccgg gggtctacac caacgaggcc tttcatcccg atatagtgct 14700 cctgcccggc tgtggggtgg actttaccca gagccggctg agcaacctgc tgggcgttcg 14760 caagcggcaa cctttccagg agggtttcaa gatcacctat gaggatctgg aggggggcaa 14820 cattcccgcg ctccttgatc tggacgccta cgaggagagc ttgaaacccg aggagagcgc 14880 tggcgacagc ggcgagagtg gcgaggagca agccggcggc ggtggcagcg cgtcggtaga 14940 aaacgaaagt actcccgcag tggcggcgga cgctgcggag gtcgagccgg aggccatgca 15000 gcaggacgca gaggagggcg cgcaggagga catgaacaat ggggagatca ggggcgacac 15060 tttcgccacc cggggcgaag aaaaagaggc agaggcggcg gcggcgacgg cggaagccga 15120 aaccgaggca gaggcagagc ccgagaccga agttatggaa gacatgaatg atggagaacg 15180 taggggtgac acgtttgcca cccggggcga agagaaggcg gcggaggcag aagccgcggc 15240 tgaggaggcg gctgcggctg cggccaaggc tgaggctgcg gctgaggcta aggtcgaagc 15300 cgatgttgcg gttgaggctc aggctgagga ggaggcggcg actgaagcag ttaaggaaaa 15360 ggcccaggca gagcaggaag agaaaaaacc tgtcattcaa cctctaaaag aagatagcaa 15420 aaagcgcagt tacaacgtca tcgagggcag cacctttacc caataccgca gctggtacct 15480 ggcttacaac tacggcgacc cggtcaaggg ggtgcgctcg tggaccctgc tctgcacgcc 15540 ggacgtcacc tgcggctccg agcagatgta ctggtcgctg ccaaacatga tgcaagaccc 15600 ggtgaccttc cgttccacgc ggcaggttag caactttccg gtggtgggcg ccgaactgct 15660 gccagtgcac tccaagagtt tttacaacga gcaggccgtc tactcccagc tgatccgcca 15720 ggccacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc 15780 gccggccccc accatcacca ccgtcagtga aaacgttcct gccctcacag atcacgggac 15840 gctaccgctg cgcaacagca tctcaggagt ccagcgagtg accattactg acgccagacg 15900 ccggacctgc ccctacgttt acaaggcctt gggcatagtc tcgccgcgcg tcctctccag 15960 tcgcactttt taaaacacat ctaccctcac gctccaaaat catgtccgta ctcatctcgc 16020 ccagcaacaa caccggctgg gggctgcgcg cgcccagcaa gatgtttgga ggggcgagga 16080 aacgctccga acagcaccca gtgcgcgtgc gcggccacta ccgcgcgccc tggggtgcgc 16140 acaagcgcgg gcgcacaggg cgcaccactg tggatgatgt cattgactcc gtagtggagc 16200 aggcgcgcca ctacacaccc ggcgcgccga ccgcctccgc cgtgtccacc gtggaccagg 16260 cgatcgaaag cgtggtacag ggggcgcggc actatgccaa ccttaaaagt cgccgccgcc 16320 gcgtggcgcg ccgccatcgc cggagacccc gggctactgc cgccgcgcgc cttaccaagg 16380 ctctgctcaa gcgcgccagg cgaactggcc accgggccgc catgagggcc gcacggcggg 16440 ctgccgctgc cgcgagcgcc gtggccccgc gggcacgaag gcgcgcggcc gctgccgccg 16500 ccgccgccat ttccagcttg gcctcgacgc ggcgcggtaa catatactgg gtgcgcgact 16560 cggtaagcgg cacacgggtg cccgtgcgct ttcgcccccc acggaattag cacaaaacaa 16620 catacacact gagtctcctg ctgttgtgta tcccagcggc gaccgtcagc agcggcgaca 16680 tgtccaagcg caaaattaaa gaagagatgc tccaggtcat cgcgccggag atctatgggc 16740 ccccgaagaa ggaggaggat gattacaagc cccgcaagct aaagcgggtc aaaaagaaaa 16800 agaaagatga tgacgttgac gaggcggtgg agtttgtccg ccgcatggcg cccaggcgcc 16860 ccgtgcagtg gaagggtcgg cgcgtgcagc gagtcctgcg ccccggcacc gcggtggtct 16920 ttacgcccgg cgagcgttcc acgcgcactt tcaagcgggt gtacgatgag gtgtacggcg 16980 acgaggatct gttggagcag gccaaccatc gctttgggga gtttgcatat gggaaacggc 17040 cccgcgagag cctaaaagag gacctgctgg cgctaccgct ggacgagggc aatcccaccc 17100 cgagtctgaa gccggtaacc ctgcaacagg tgctgccttt gagcgcgccc agcgagcaga 17160 agcgagggtt gaagcgcgag ggcggggacc tggcacccac cgtgcagttg atggtgccca 17220 agcggcagaa gctggaggac gtgctggaga aaatgaaagt agagcccggg atccagcccg 17280 aaatcaaggt ccgccccatc aagcaggtgg cgcccggcgt gggagtccag accgtggacg 17340 ttaggattcc cacggaggag atggaaaccc aaaccgccac tccctcttcg gcggctagcg 17400 ccaccaccgg cgccgcttcg gtagaggtgc agacggaccc ctggctacct gccgccactg 17460 tcgccgccgc cgccgccgcc ccccgttcgc gcgggcgcaa gagaaattat ccagcggcca 17520 gcgcgctcat gccccagtac gcactgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcacccgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcattg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg cctccgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcagag gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgctg 17940 cccttcctaa tcccgctaat cgccgcggcg atcggtgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc attttttgga 18060 ggaaaaaata aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagt ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggccaga tgctgagaga caagttgaaa gagcagaact tccaggaaaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccggcctcag gtggaggaaa cgcctccagc 18480 aatggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcctaccact cgccccatag cccccatggc caccggtgtg gtgggacaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgatccgcct cgccagccaa aggcggcgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgccc ctgcgccgcg ctgcaagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gtttatcccc gtggatcggg 19200 aggacaccgc ctactcttac aaggcgcggt ttacgctggc cgtgggcgac aatcgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggt cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggctcctaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaac caggtggtcg ctgcagatga tgaacttgag gatgaggaag 19440 cgcaggcaca agaggaagcc cctgtgaaaa aaattcatgt gtatgctcag gcgcctcttt 19500 ccggcgaaaa gatttccaag gatggcatcc aaataggcac tgaagtcgta ggagatacat 19560 ctaaggacac ttttgccgac aaaacattcc agcccgaacc tcagataggc gaatctcagt 19620 ggaatgaagc tgatgccaca gcagcaggag gtagggtttt gaagaagact actcccatga 19680 ggccttgtta tggatcttat gctaggccta ccaatgccaa cggaggccaa ggaattatgg 19740 ttgccaatga acaaggagtg ttggagtcta aagtagaaat gcagtttttc tctaacacca 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtatagtg 19860 aagatgtcca cttggaatct cccgatactc acctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa aatcatgttg ggccaacagg ctatgcccaa taggcccaat cttattggat 19980 ttagagataa tttcattggg ctcatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaagc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 cgtatcagct tttgcttgat tccattgggg atagaaccag atatttctcc atgtggaacc 20160 aggcagtgga tagttatgac ccagatgtca gaatcattga aaaccacggg actgaggacg 20220 aactgcctaa ctactgtttt cctctgggcg gcattggagt tacagatact tatcaaggga 20280 taaaaaatac taatggcaat ggtcaatgga ccaaagatga tcagtttgcg gaccgcaatg 20340 aaataggggt gggaaacaac tttgccatgg agatcaacat ccaggccaac ctctggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcacc cactatgcgc gagggacagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac tttcgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgcctgca tgactggttc caccgagcaa gagctcaggg 21900 ccatcgccag agacctggga tgcggaccct actttttggg cacctatgac aaacgcttcc 21960 cgggtttcat ctcccgagac aagctcgcct gcgccatcgt caacacggcc gcgcgcgaga 22020 ccgggggcgt gcactggctg gcctttggct gggacccgcg ctctaaaact tgctacctct 22080 ttgacccctt tggcttctct gatcagcgcc tcaggcagat ttatgagttt gagtacgagg 22140 ggctgctgcg ccgcagcgcg cttgcctcct cgcccgaccg ctgcatcacc cttgagaagt 22200 ccaccgagac cgtgcagggg ccccactcgg ccgcctgcgg tctcttctgt tgcatgtttt 22260 tgcacgcctt tgtacactgg cctcagagtc ccatggatcg caaccccacc atgaacttgc 22320 taaagggagt gcccaacgcc atgctccaga gcccccaggt cctgcccacc ctgcgccgca 22380 accaggaaca gctctaccgc ttcctggagc gccactcccc ctacttccgc agccacagcg 22440 cgcgcatccg gggggccacc tctttttgcc acttgcaaga aaacatgcaa gacggaaaat 22500 gatgtacagc atgcttttaa taaatgtaaa gactgtgcac tttatttata cacgggctct 22560 ttctggttat ttattcaaca ccgccgtcgc catctagaaa tcgaaagggt tctgccgcgc 22620 gtcgccgtgc gccacgggca gagacacgtt gcgatactgg aagcggctcg cccacttgaa 22680 ctcgggcacc accatgcggg gcagtggttc ctcggggaaa ttctcgctcc acagggtgcg 22740 ggtcagctgc agcgcgctca ggaggtcggg agccgagatc ttgaagtcgc agttggggcc 22800 ggaaccctgc gcgcgcgagt tgcggtacac ggggttgcag cactggaaca ccagcagggc 22860 cggattattc acgctggcca gcaggctctc gtcgctgatc atgtcgctgt ccagatcctc 22920 cgcgttgctc agggcgaatg gggtcatctt gcagacctgc ctgcccagga aaggcgggag 22980 cccaggcttg ccgttgcagt cgcagcgcag gggcattagc aggtgcccac ggcccgactg 23040 cgcctgcggg tacaacgcgc gcatgaaggc ttcgatctgc ctaaaagcca cctgggtctt 23100 ggctccctcc gaaaagaaca tcccacagga cttgctggag aactgattcg cgggacagct 23160 ggcatcgtgc aggcagcagc gcgcgtcagt gttggcgatc tgcaccacgt tgcgacccca 23220 ccggtttttc actatcttgg ccttggaagc ctgctccttt agcgcgcgct ggccgttctc 23280 gctggtcaca tccatctcta tcacctgttc cttgttgatc atgtttgtcc cgtgcagaca 23340 ctttaggtcg ccctccgtct gggtgcagcg gtgctcccac agcgcgcaac cggtgggctc 23400 ccaattcttg tgggtcaccc ccgcgtaggc ctgcaggtag gcctgcagga agcgccccat 23460 catggtcata aaggtcttct ggctcgtaaa ggtcagctgc aggccgcgat gctcttcgtt 23520 cagccaggtc ttgcagatgg cggccagcgc ctcggtctgc tcgggcagca tcttaaaatt 23580 tgtcttcagg tcgttatcca cgtggtactt gtccatcatg gcacgcgccg cctccatgcc 23640 cttctcccag gcggacacca tgggcaggct tagggggttt atcacttcca gcggcgagga 23700 caccgtactt tcgatttctt cttcctcccc ctcttcccgg cgcgcgcccc cgctgttgcg 23760 cgctcttacc gcctgcacca aggggtcgtc ttcaggcaag cgccgcaccg agcgcttgcc 23820 gcccttgacc tgcttgatca gtaccggcgg gttgctgaag cccaccatag tcagcgccgc 23880 ctgctcttct tcgtcttcgc tgtctaccac tatttctggg gaggggcttc tccgctctgc 23940 ggcaaaggcg gcggatcgct tctttttttt cttgggagcc gccgcgatgg agtccgccac 24000 ggcgaccgag gtcgagggcg tggggctggg ggtgcgcggc accagggcct cgtcgccctc 24060 ggactcttcc tctgactcca ggcggcggcg gagtcgcttc tttgggggcg cgcgcgtcag 24120 cggcggcgga gacggggacg gggacgggga cgggacgccc tccacagggg gcggtcttcg 24180 cgcagacccg cggccgcgct cgggggtctt ctcgcgctgg tcttggtccc gactggccat 24240 tgtatcctcc tcctcctagg cagagagaca taaggagtct atcatgcaag tcgagaagga 24300 ggagagctta accaccccct ctgagaccgc cgtcgccgtc gcccccgcta ccgccgacgc 24360 gcccgccaca ccgagcgaca cccccgcgga cccccccgcc gacgcacccc tgttcgagga 24420 agcggccgtg gagcaggacc cgggctttgt ctcggcagag gaggatttgc aagaggagga 24480 ggataaggag gagaagccct cagtgccaaa agatcataaa gagcaagacg agcacgacgc 24540 agacgcacac cagggtgaag tcgggcgggg ggacggaggg catggcggcg ccgactacct 24600 agacgaagga aacgacgtgc tcttgaagca cctgcatcgt cagtgcgcca tcgtctgcga 24660 cgctctgcag gagcgcagcg aggtgcccct cagcgtggcg gaggtcagcc gcgcctacga 24720 gctcagcctc ttttcccccc gggtgccccc ccgccgccgc gaaaacggca catgcgagcc 24780 caacccgcgc ctcaacttct accccgcctt tgtggtgccc gaggtcctgg ccacctatca 24840 catcttcttt caaaattgca agatccccat ctcgtgccgc gccaaccgta gccgcgccga 24900 taagatgctg gccctgcgcc agggcgacca catacctgat atcgccgctt tggaagatgt 24960 accaaagatc ttcgagggtc tgggtcgcaa cgaaaagcgg gcagcaaact ctctgcaaca 25020 ggaaaacagc gaaaatgaga gtcacaccgg ggtgctggtg gagctcgagg gcgacaacgc 25080 ccgcctggcg gtgctcaagc gcagcatcga ggtcacccac tttgcctacc ccgcgctcaa 25140 cctgcccccc aaagtcatga acgcggtcat ggacgggctg atcatgcgcc gcggccagcc 25200 ccttgctcca gatgcaaact tgcatgagga gaccgaggac ggccagcccg tggtcagcga 25260 cgagcagctg gcgcgctggc tggaaaccgc ggaccccgcc gaactggagg agcggcgcaa 25320 gatgatgatg gccgcggtgc tggtcaccgt agagctggag tgtctgcagc gcttcttcgg 25380 tgaccccgag atgcagagaa aggtcgagga gaccctacac tacaccttcc gccagggcta 25440 cgtgcgccag gcttgcaaga tctccaacgt ggagctcagc aacctggtgt cctacctggg 25500 catcttgcat gagaaccgcc ttgggcagag cgtgctgcac tccaccctgc gcggggaagc 25560 gcgccgcgac tacgtgcgcg actgcgttta ccttttcctc tgctacacct ggcagacggc 25620 catgggggtc tggcagcagt gcctggagga gcgcaacctc aaggagctgg agaagctcct 25680 gcagcgcgcg ctcaaagacc tctggacggg cttcaacgag cgctcggtgg ccgccgcgct 25740 ggccgacctc atcttccccg agcgcctgct caaaactctc cagcaggggc tgcccgactt 25800 caccagccaa agcatgttgc aaaactttag gaactttatc ctggagcgtt ctggcatcct 25860 acccgccacc tgctgcgccc tgcccagtga ctttgttccc ctcgtgtacc gcgagtgccc 25920 cccgccgctg tggggccact gctacctgtt ccaactggcc aactacctgt cctaccacgc 25980 ggacctcatg gaggactcca gcggcgaggg gctcatggag tgccactgcc gctgcaacct 26040 ctgcacgccc caccgctccc tggtctgcaa cacccaactg ctcagcgaga gtcagattat 26100 cggtaccttc gagctacagg gtccgtcctc ctcagacgag aagtccgcgg ctccggggct 26160 aaaactcact ccggggctgt ggacttccgc ctacctgcgc aaatttgtac ctgaagacta 26220 ccacgcccac gagatcaggt tttacgagga ccaatcccgc ccgcccaagg cggagctgac 26280 cgcctgcgtc atcacccagg gcgagatcct aggccaattg caagccatcc aaaaagcccg 26340 ccaagagttt ttgctgagaa agggtcgggg ggtgtatctg gacccccagt cgggtgagga 26400 gctcaacccg gttcccccgc tgccgccgcc gcgggacctt gcttcccagg ataagcatcg 26460 ccatggctcc cagaaagaag cagcagcggc cgccactgcc gccaccccac atgctggagg 26520 aagaggagta ctgggacagt caggcagagg aggtttcgga cgaggaggag ccggagacgg 26580 agatggaaga gtgggaggag gacagcttag acgaggaggc ttccgaagcc gaagaggcag 26640 gcgcaacacc gtcaccctcg gccgcagccc cctcgcaggc gcccccgaag tccgctccca 26700 gcatcagcag caacagcagc gctataacct ccgctcctcc accgccgcga cccacggccg 26760 accgcagacc caaccgtaga tgggacacca ccggaaccgg ggccggtaag tcctccggga 26820 aaggcaagca agcgcagcgc caaggctacc gctcgtggcg cgctcacaag aacgccatag 26880 tcgcttgctt gcaagactgc ggggggaaca tctccttcgc ccgccgcttc ctgctcttcc 26940 accacggtgt ggccttcccc cgtaacgtcc tgcattacta ccgtcatctc tacagcccct 27000 actgcggcgg cagtgagcca gaggcggccg gcggcagcgg cgcccgtttc ggtgcctagg 27060 aagacccagg gcaagacttc agccaagaaa ctcgcggcgg ccgcggcgaa cgcggtcgcg 27120 ggggccctgc gcctgacggt gaacgaaccc ctgtcgaccc gcgaactgag gaaccgaatc 27180 ttccccactc tctatgccat cttccagcag agcagagggc aggatcagga actgaaagta 27240 aaaaacaggt ctctgcgctc cctcacccgc agctgtctgt atcacaagag cgaagaccag 27300 cttcggcgca cgctggagga cgctgaggca ctcttcagca aatactgcgc gctcactctt 27360 aaggactagc tccgcgccct tctcgaattt aggcgggaac gcctacgtca tcgcagcgcc 27420 gccgtcatga gcaaggacat tcccacgcca tacatgtgga gctatcagcc gcagatggga 27480 ctcgcggcgg gcgcctccca agactactcc acccgcatga actggctcag tgccggccca 27540 cacatgatct cacaggttaa tgacatccgc acccatcgaa accaaatatt ggtggagcag 27600 gcggcaatta ccaccacgcc ccgcaataat cccaacccca gggagtggcc cgcgtccctg 27660 gtgtatcagg aaattcccgg ccccaccacc gtactacttc cgcgtgattc ccaggccgaa 27720 gtccaaatga ctaactcagg ggcacagctc gcgggcggct gtcgtcacag ggtgcggcct 27780 cctcgccagg gtataactca cctggagatc cgaggcagag gtattcagct caacgacgag 27840 tcggtgagct cctcgctcgg tctcagacct gacgggacct tccagatagc cggagccggc 27900 cgatcttcct tcacgccccg ccaggcgtac ctgactctgc agagctcgtc ctcggcgccg 27960 cgctcgggcg gcatcgggac tctccagttc gtgcaggagt ttgtgccctc ggtctacttc 28020 aaccccttct cgggctctcc cggtcgctac ccggaccagt tcatcccgaa ctttgacgcc 28080 gcgagggact cggtggacgg ctacgactga atgtcgggtg gacccggtgc agagcaactt 28140 cgcctgaagc accttgacca ctgccgccgc cctcagtgct ttgcccgctg tcagaccggt 28200 gagttccagt acttttccct gcccgactcg cacccggacg gcccggcaca cggggtgcgc 28260 tttttcatcc cgagtcaggt ccgctctacc ctaatcaggg agtttacagc ccgtccccta 28320 ctggcggagt tggaaaaggg gccttctatc ctaaccattg cctgcatctg ctctaaccct 28380 ggattacacc aagatctttg ctgtcatttg tgtgctgagt ataataaagg ctgagatcag 28440 aatctactcg ggctcctgtc gccatcctgt caacgccacc gtccaagccc ggcccgatca 28500 gcccgaggtg aacctcacct gcggtctgca ccggcgcctg aggaaatacc tagcttggta 28560 ctacaacagc actccctttg tggtttacaa cagctttgac caggacgggg tctcactgag 28620 ggataacctc tcgaacctga gctactccat caggaagaac aacaccctcg agctacttcc 28680 tccttacctg cccgggactt accagtgtgt caccggtccc tgcacccaca cccacctgtt 28740 gatcgtaaac gactctcttc cgagaacaga cctcaataac tcctctccgc agttccccag 28800 aacaggaggt gagctcagga aaccccgggt aaagaagggt ggacaagagt taacacttgt 28860 ggggtttctg gtgtatgtga cgctggtggt ggctcttttg attaaggctt ttccttccat 28920 gtctgaactc tccctcttct tttatgaaca actcgactag tgctaacgag accctaccca 28980 acgaatcggg attgaatatc ggtaaccagg ttgcagtttc acttttgatt acctttatag 29040 tcctcttcct gctagtgctg tcgcttctgt gcctgcggat cgggggctgc tgcatccacg 29100 tttatatctg gtgctggctg tttagaaggt tcggagacca ccgcaggtag aataatgctg 29160 cttaccctct ttgtcctggc gctggctgcc agctgccaag ccttttccga ggctgacttc 29220 atagagcccc agtgcaatat cacttataaa tctgaacgtg ccatctgtac tatcctaatc 29280 aaatgtgtta ctcaacacga taaggtaact gttaaataca aagatcaatt aaaaaaagac 29340 gcactttaca gcagctggca accaggagat gaacaaaaat acaatgtaac cgtcttccag 29400 ggcaaactct ccaaaactta caattacact ttcccatttg agcagatgtg tgactttgtc 29460 atgtacatgg aaaagcagta caagctgtgg cctccaactc cccagggctg tgtggaaaat 29520 ccaggctctt tctgtatgat ctctctctgt gtaactgtgc tggcactaat actcacgctt 29580 ctgtatatca gatttaaatc aaggcaaagc tttattgatg aaaagaaaat gccttaatcg 29640 ctttcacgct tgattgctaa caccgggttt ttatccgcag aatgattgga atcaccctac 29700 taatcacctc cctccttgcg attgcccatg ggttggaacg aatcgaagtc cctgtggggg 29760 ccaatgttac cctggtgggg cctgtcggca atgctacatt aatgtgggaa aaatatacta 29820 aaaatcaatg ggtctcttac tgcactaaca aaaacagcca caagcccaga gccatctgcg 29880 atgggcaaaa tttaaccttg attgatgttc aattgctgga tgcgggctac tattatgggc 29940 agctgggtac aatgattaat tactggagac cccacagaga ttacatgctt cacgtagtaa 30000 agggtcccat tagcagccca accaccacct ctaccacccc cactaccacc actactccca 30060 ccaccagcac tgccgcccag cctcctcata gcagaacaac cacttttatc aattccaagt 30120 cccactcccc ccacattgcc ggcgggccct ccgcctcaga ctccgagacc accgagatct 30180 gcttctgcaa atgctctgac gccattgccc aggatttgga agatcacgag gaagatgagc 30240 atgactacgc agatgcatgc caggcatcag agtcagaagc gctgccggtg gccctaaaac 30300 agtatgcaga cccccacacc acccccgacc ttcctccacc ttcccagaag ccaagtttcc 30360 tgggggaaaa tgaaactctg cctctctcca tactagctct gacatctgtt gctattttgg 30420 ccgctctgct ggtgcttcta tgctctatat gctacctgat ctgctgcaga aagaaaaaat 30480 ctcacggcca tgctcaccag cccctcatgc acttccctta ccctccagag ctgggcgacc 30540 acaaacttta agtctgcagt agctatctgc ccatcccttg tcagtcgaca gcgatgagcc 30600 ccactaatct aacagcctct ggacttacaa cattgtctct taatgagacc accgctcctc 30660 aagacctgta cgatggtgtc tccgcgctgg ttaaccagtg ggatcacctg ggcatatggt 30720 ggctcctcat aggagcagtg accctgtgcc taatcctggt ctggatcatc tgctgcatca 30780 aaagcagaag acccaggcgg cggcccatct acaggccctt cgtcatcaca cctgaagata 30840 atgatgatga tgacaccacc tccaggctgc agagcctaaa gcagctactc ttctctttta 30900 cagcatggta aattgaatca tgccccgcat tttcatctac ttgcttctcc ttccactttt 30960 tctgggctcc tctacattgg ccgctgtgtc ccacatcgag gtagactgcc tcacgccctt 31020 cacagtctac ctgcttttcg gctttgtcat ctgcaccttt gtctgcagcg ttatcactgt 31080 agtgatctgc ttcatacagt gcatcgacta catctgtgtg cgggtggcct actttagaca 31140 ccacccccag tatcgcaaca gggacatagc ggctctccta agacttgttt aaatcatggc 31200 caaattacct gtgattggtc ttctgattat ctgctgcgtc ctagccgcga ttgggactca 31260 acctaatacc accaccagcg ctcccagaaa gagacatgta tcctgcagct tcaagcgtcc 31320 ctggaatata ccccaatgct ttactgatga acctgaaatc tctttggctt ggtacttcag 31380 cgtcaccgcc cttctcatct tctgcagtac ggttattgct cttgccatct acccttccct 31440 taacctgggc tggaatgctg tcaactctat ggaatatccc accttcccag aaccagacct 31500 gccagacctg gttgttctaa acgcgtttcc tcctcctcca gttcaaaatc agtttcgccc 31560 tccgtcccct acgcccactg aggtcagcta ctttaatcta acaggcggag atgactgaaa 31620 acctagacct agaaatggac ggtctctgca gcgagcaacg cacactagag aggcgccggc 31680 aaaaagcaga gctcgagcgt cttaaacaag agctccaaga cgccgtggcc atacaccagt 31740 gcaaaaaagg gctcttctgt ctggtaaaac aggccacgct cacctatgaa aaaacaggtg 31800 acacccaccg cctaggatac aagctgccca cacagcgcca aaagtttgcc cttatgatag 31860 gtgaacaacc catcaccgtc acccagcact ccgtggagac agaaggctgc attcatgctc 31920 cctgcagggg cgctgactgc ctctacacct tgatcaaaac cctctgcggt ctcagagacc 31980 ttatcccttt caattgatca taactgtaat caataaaaaa tcacttactt gaaatctgat 32040 agcaagcctc tgtccaattt tttcagcaac acttccttcc cctcttccca actctggtac 32100 tctaggcgcc tcctagctgc aaacttcctc cacagtctga agggaatgtc agattcctcc 32160 tcctcctgtc cctccgcacc cacaatcttc atgttgttgc agatgaaacg cgcgagatcg 32220 tctgacgaga ccttcaaccc cgtgtacccc tacgataccg agatcgctcc gacttctgtc 32280 cctttcctta cccctccctt tgtgtcaccc gcaggaatgc aagaaaatcc agctggggtg 32340 ctgtccctgc acctgtcaga gccccttacc acccacaatg gggccctgac tctaaaaatg 32400 gggggcggcc tgaccctgga caaggaaggg aatctcactt cccaaaacat caccagtgtc 32460 gatccccctc tcaaaaaaag caagaacaac atcagccttc agaccgccgc acccctcgcc 32520 gtcagctccg gggccctaac cctttttgcc actccccccc tagcggtcag tggcgacaac 32580 cttactgtgc agtctcaggc ccctcttact ttggaagact caaaactaac tctggccacc 32640 aaaggacccc taactgtgtc cgaaggcaaa cttgtcctag aaacagaggc tcccctgcat 32700 gcaagtgaca gcagtagcct gggccttagc gtcacggccc cacttagcat taacaatgac 32760 agcctaggac tagatctgca ggcacccatt gtctctcaaa atggaaaact ggctctaaat 32820 atagcaggcc ccctagctgt agccgatagc attaatgctt tgacagtagg cactggcaaa 32880 ggtattggac taaatgaaac cagcactcac ttgcaagcaa aattggttgc ccccctaggc 32940 tttgatacca atggcaatat taagctaagc gttgcaggag gcatgaggct aaacaatgac 33000 acactgatac tagatgtaaa ctacccattt gaagctcaag gtcaactaag cctaagagtg 33060 ggcacaggtc cactgtatgt agattctagc agtcataatc taaccattag atgccttagg 33120 ggattgtata taacatcatc taacaaccaa aacggtctag aggccaacat taaactaaca 33180 aaaggccttg tgtatgaagg aaatgccata gcagttaatg ttggtcaagg attgcaatac 33240 agcactactg ccacatcgga aggtgtgtat cctatacagt ctaagatagg tttgggaatg 33300 gaatatgata ccaacggagc catgatggca aaactaggct ccggtctaag ctttgataat 33360 tcaggagcca ttgtggtggg aaacaaaaat gatgacaaac ttaccctatg gaccacacct 33420 gacccgtctc ctaactgtag aatttattct gaaaaagata ctaaactaac cttggtgctg 33480 actaagtgtg gcagtcaaat cctaggcaca gtatctgccc ttgctgtcag aggcagcctt 33540 gcgcccatca ctaacgcatc cagcatagtc caaatatttc tacgatttga tgaaaatgga 33600 ctattgatga gcaactcatc gctagacggt gattactgga attacagaaa tggggactcc 33660 actaatggca caccatatac aaatgcagta ggctttatgc ctaatctagc tgcctatcct 33720 aaaggtcagg ctacaactgc aaaaagcagt attgtaagcc aggtatacat ggatggtgat 33780 actactaaac ctataacact aaaaataaac tttaatggca ttgatgaaac aacagaaaat 33840 acccctgtta gtaaatattc catgacattc tcatggagct ggcccaccgc aagctacata 33900 ggccacactt ttgcaacaaa ctcttttact ttctcctaca tcgcccaaga ataaagaaag 33960 cacagagatg cttgtttttg atttcaaaat tgtgtgcttt tatttatttt caagcttaca 34020 gtatttccag tagtcattca aatagagctt aatgaaactg catgagaacc cttccacata 34080 gcttaaatta tcaccagtgc aaatggagaa aaaatcaaca taccttttta tccagatatc 34140 atagaactct agtggtcagt tttcccccac cctcccagct cacagaatac acagtccttt 34200 ccccccggct ggctttaaac aacactatct cattggtaac agacatattc ttaggtgtaa 34260 taatccacac ggtctcttgg cgggccaaac gctggtcagt gatgttaata aactccccag 34320 gcagctcttt caagttcacg tcgctgtcca actgctgaag cgctcgcggc tccgactgcg 34380 cctctagcgg aggcaacggc aacacccgat ccttgatcta taaaggagta gagtcataat 34440 cccccataag aatagggcgg tgatgctgca acaaggcgcg cagcaactcc tgccgccgcc 34500 tttccgtacg acaggaatgc aacggggtgg tggtctcctc cgcgataatc cgcaccgctc 34560 gcaacatcag cgtcctcgtc ctccgggcac agcagcgcat cctgatctca ctgagatcgg 34620 cgcagtaagt gcagcacaac accaagatgt tatttaagat cccacagtgc aaagcactgt 34680 acccaaagct catggcggga aggacagccc ccacgtgacc atcataccag atcctcaggt 34740 aaatcaaatg acgacctctc atgaacacgc tggacatgta catcacctcc ttaggcatgt 34800 gctgattcac cacctctcga taccacaggc atcgctgatt aattaaagac ccctcgagca 34860 ccatcctgaa ccaggaagcc agcacctgac cccccgccag gcactgcagg gaccccggtg 34920 aatcgcagtg gcagtgaaga ctccagcgct cgtagccgtg aaccatagag ctggtcatta 34980 tatccacatt ggcacaacac agacacactt tcatacactt tttcatgatt agcagctcct 35040 ctctagtcag gaccatatcc caaggaatca cccactcttg aatcaaggta aatcccacac 35100 agcagggcag gcctctcaca taactcacgt tatgcatagt gagcgtgtcg caatctggaa 35160 ataccggatg atcttccatc accgaagccc gggtctccgt ctcaaaggga ggtaaacggt 35220 ccctcgtgta gggacagtgg cgggataatc gagatcgtgt tgaacgtaga gtcatgccaa 35280 agggaacagc ggacgtactc atatttcctc cagcagaacc aagtgcgcgc gtggcagcta 35340 tccttgcgtc ttctgtctcg ccgcctgccc cgctcggtgt agtagttgta atacagccac 35400 tccctcagac cgtcaaggcg ctccctggcg tccggatcta taacaacacc atcctgcagc 35460 gccgccctga tgacatccac caccgtagag tatgccaagc ccagccagga aatgcactca 35520 ctttgacagc gagagatagg aggagcggga agagatggaa gaaccatgat agtaaaagaa 35580 cttttattcc aatcgatcct ctacaatgtc aaagtgtaga tctatcagat ggcactggtc 35640 tcctccgctg agtcgatcaa aaataacagc taaaccacaa acaacacgat tggtcaaatg 35700 ctgcacaagg gcttgcagca taaaatcgcc tcgaaagtcc accgcaagca taacatcaaa 35760 gccaccgccc ctatcatgat ctatgataaa aaccccacag ctatccacca gacccatata 35820 gttttcatct ctccatcgtg aaaaaatatt tacaagctcc tcctttaaat cacctccaac 35880 caattcaaaa agttgagcca gaccgccctc caccttcatt ttcagcatgc gcatcatgat 35940 tgcaaaaatt caggctcctc agacacctgt ataagattga gaagcggaac gttaacatca 36000 atgtttcgct cgcgaagatc gcgcctcagt gcaagcatga tataatccca caggtcggag 36060 cggatcagcg aggacatctc cccgccagga accaactcaa cggagcctat gctgattata 36120 atacgcatat tcggggctat gctaaccagc acggccccca aataggcgta ctgcataggc 36180 ggcgacaaaa agtgaacagt ttgggttaaa aaatcaggca aacactcgcg caaaaaagca 36240 agaacatcat aaccatgctc atgcaaatag atgcaagtaa gctcaggaac gaccacagaa 36300 aaatgcacaa tttttctctc aaacatgact gcgagccctg caaaaataaa aaagaaacat 36360 tacacaagag tagcctgtct tacaatggga tagactactc taaccaacat aagacgggcc 36420 acaacatcgc ccgcgtggcc ataaaaaaaa ttatccgtgt gattaaaaag aagcacagat 36480 agctggccag tcatatccgg agtcatcacg tgcgaacccg tgtagacccc cgggttggac 36540 acatcggcca aacaaagaaa gcggccaatg tatcccggag gaatgataac actaagacga 36600 agatacaaca gaataacccc atggggggga ataacaaagt tagtaggtga ataaaaacga 36660 taaacacccg aaactccctc ctgcgtaggc aaaatagcgc cctccccttc caaaacaaca 36720 tatagcgctt ccacagcagc catgacaaaa gactcaaaac actcaaaaga ctcagtctta 36780 ccaggaaaat aaaagcactc tcacagcacc agcactaatc agagtgtgaa aaaggccaag 36840 tgccgaacga gtatatatag gaattaaaaa tgacgtaaat gtgtaaaggt cagaaaacgc 36900 ccagaaaaat acacagacca acgcccgaaa cgaaaacccg cgaaaaaata cccagaagtt 36960 cctcaacaac cgccacttcc gctttcccac gagacgtcac ttcctcaaaa atagcaaact 37020 acatttccca catatacaaa accaaaaccc ctccccttgt caccgcccac aacttacatc 37080 atcacaaacg tcaaagccta cgtcacccgc cccgcccacc tcattatcat attggccaca 37140 atccaaaata aggtatatta ttgatgatg 37169 <210> 4 <211> 37169 <212> DNA <213> Great Ape Adenovirus <400> 4 catcatcaat aatatacctt attttggatt gtggccaata tgataatgag gtgggcgggg 60 cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgc ggaagtgtgg catttgcaag 120 tgggaggagc tcacatgtaa gcttccgtcg cggaaaatgt gacgttttta atgagcgccg 180 cctacctccg gaagtgccaa ttttcgcgcg cttttcaccg gatatcgtag taattttggg 240 cgggaccatg taagatttgg ccattttcgc gcgaaaagtg aaacggggaa gtgaaaactg 300 aataataggg cgttagtcat agcgcgtaat atttaccgag ggccgaggga ctttgaccga 360 ttacgtggag gactcgccca ggtgtttttt acgtgaattt ccgcgttccg ggtcaaagtc 420 tccgttttta ttgtcaccgt catctgacgc ggagggtatt taaacccgct gcgctcctaa 480 agaggccact cttgagtgcc agcgagaaga gttttctcct ccgctccgtt tcggcgatcg 540 aaaaatgaga cacttagcct gcactccggg tcttttgtcc ggccgggcgg cgtccgagct 600 tttggacgct ttgctcaatg aggttctgag cgatgatttt ccgtctacta cccactttag 660 cccacctact cttcacgaac tgtacgatct ggatgtactg gtggatgtga acgatcccaa 720 cgaggaggcg gtttctacgt tttttcccga gtctgcgctt ttggccgccc aggagggatt 780 tgacctacac actccgccgc tgcctatttt agagtctccg ctgccggagc ccagtggtat 840 accttatatg cctgaactgc ttcccgaagt ggtagacctg acctgccacg agccgggctt 900 tccgcccagc gacgatgagg gtgagccttt tgctttagac tatgctgaga tacctgggct 960 cggttgcagg tcttgtgcat atcatcagag ggttaccgga gaccccgagg ttaagtgttc 1020 gctgtgctat atgaggctga cctcttcctt tatctacagt aagttttttg tgtaggtggg 1080 ctttttgggt aggtgggttt tgtggcagga caggtgtaaa tgttgcttgt gttttttgta 1140 cctgcaggtc cggtgtccga gccagacccg gagcccgacc gcgatcccga gccggatccc 1200 gagcctcctc gcagggcaag gaaattacct tccattttgt gcaagcctaa gacacctgtg 1260 aggaccagcg aggcggacag cactgactct ggcacttcta cctctcctcc tgaaattcac 1320 ccagtggttc ctttgggtat acataaacct gttgctatta gagtttgcgg gcgacgccct 1380 gcagtagagt gcattgagga cttgcttaac gatcccgagg gacctttgga cttgagcatt 1440 aaacgcccta ggcaataaac cccacctaag taataaaccc cacctaagta ataaacttta 1500 ccgcccttgg ttattgagat gacgcccaat gtttgctttt gaatgacttc atgtgtataa 1560 taaaagtgag tgtggtcata ggtctcttgt ttgtctgggc ggggcttaag ggtatataag 1620 tttctcgggg ctaaacttgg ttacacttga ccccaatgga ggcgtggggg tgcttggagg 1680 agtttgcgga cgtgcgccgt ttgctggacg agagctctag caatacctat agtatttgga 1740 ggtatctgtg gggctctact caggccaagt tggtctccag aattaagcag gattacaagt 1800 gcgattttga agagcttttt agttcctgtg gtgagctttt gcaatccttg aatctgggcc 1860 accaggctat cttccaggaa aaggttctct cgactttgga tttttccact cccgggcgca 1920 ccgccgcttg tgtggctttt gtgtcttttg tgcaagataa atggagcggg gagacccacc 1980 tgagtcacgg ctacgtgctg gatttcatgg cgatggctct ttggagggct tacaacaaat 2040 ggaagattca gaaggaactg tacggttccg ccctacgtcg tccacttctg cagcggcagg 2100 ggctgatgtt tcccgaccat cgccagcatc agaatctgga agacgagtcg gaggagcgag 2160 cggagaagat cagcttgaga gccggcctgg accctcctca ggaggaatga atctcccgca 2220 ggtggttgac ctgtttcccg aactgagacg ggtcctgact atcagggaag atggtcagtt 2280 tgtgaagaag ctgaagaggg atcggggtga gggagatgat gaggcggcta gcaatttagc 2340 ttttagtctg ataacccgcc accgaccgga atgtattacc tatcagcaga ttaaggagag 2400 ttgtgccaac gagctggatc ttttgggtca gaagtatagc atagaacagc ttaccactta 2460 ctggcttcag cccggggatg attgggaaga ggcgatcagg gtgtatgcaa aggtggccct 2520 gcggcccgat tgcaagtata agattactaa gttggttaat attagaaact gctgctatat 2580 ttctgggaac ggggccgaag tggagataga tactgaggac agggtggcta ttaggtgttg 2640 catgataaac atgtggcccg ggatactggg gatggatggg gtgatattta tgaatgtaag 2700 gttcacgggc cccaacttta atggtacggt gttcatgggc aacaccaact tgctcctgca 2760 tggtgcgagt ttctatgggt ttaacaacac ctgtatagag gcctggaccg atgtaaaggt 2820 tcgaggttgt tccttttata gctgttggaa ggcggtggtg tgtcgcccta aaagcagggg 2880 ttctgtgaag aaatgcttgt ttgaaaggtg caccctaggt atcctttctg agggcaactc 2940 cagggtgcgc cataatgtgg cttcgaactg cggttgcttc atgcaagtga agggggtgag 3000 cgttatcaag cataactcgg tctgtggaaa ctgcgaggat cgcgcctctc agatgctgac 3060 ctgctttgat ggcaactgtc acctgttgaa gaccattcat ataagcagtc accccagaaa 3120 ggcctggccc gtgtttgagc ataacattct gacccgctgt tccttgcatc tgggggtcag 3180 gaggggtatg ttcctgcctt accagtgtaa cttcagccac actaaaatcc tgctggaacc 3240 cgagtgcatg actaaggtca gcctgaatgg tgtgtttgat gtgagtctga agatttggaa 3300 ggtgctgagg tatgatgaga ccaggaccag gtgccgaccc tgcgagtgcg gcggcaagca 3360 catgagaaat cagcctgtga tgttggatgt gaccgaggag cttaggcctg accatctggt 3420 gctggcctgc accagggccg agtttgggtc tagcgatgag gataccgatt gaggtgggta 3480 aggtgggcgt ggctagcagg gtgggcgtgt ataaattggg ggtctaaggg gtctctctgt 3540 ttgtcttgca acagccgccg ccatgagcga caccggcaac agctttgatg gaagcatctt 3600 tagcccctat ctgacagtgc gcatgcctca ctgggccgga gtgcgtcaga atgtgatggg 3660 ttccaacgtg gatggacgtc ccgttctgcc ttcaaattcg tctacgatgg cctacgcgac 3720 cgtgggagga actccgttgg acgccgcgac ctccgccgcc gcctccgccg ccgccgcgac 3780 cgcgcgcagc atggctacgg acctttacag ctctttggtg gcgagcagcg cggcctctcg 3840 cgcgtctgct cgggatgaga aactgactgc tctgctgctt aaactggaag acttgacccg 3900 ggagctgggt caactgaccc agcaggtctc cagcttgcgt gagagcagcc ttgcctcccc 3960 ctaatggccc ataatataaa taaaagccag tctgtttgga ttaagcaagt gtatgttctt 4020 tatttaactc tccgcgcgcg gtaagcccgg gaccagcggt ctcggtcgtt tagggtgcgg 4080 tggattcttt ccaacacgtg gtacaggtgg ctctggatgt ttagatacat gggcatgagt 4140 ccatccctgg ggtggaggta gcaccactgc agagcttcgt gctcgggggt ggtgttgtat 4200 atgatccagt cgtagcagga gcgctgggcg tggtgctgaa aaatgtcctt aagcaagagg 4260 cttatagcta gggggaggcc cttggtgtaa gtgtttacaa atctgctcag ctgggagggg 4320 tgcatccggg gggatatgat gtgcatcttg gactggattt ttaggttggc tatgttccca 4380 cccagatccc ttctgggatt catgttgtgc aggaccacca gcacggtata tccagtgcac 4440 ttgggaaatt tatcgtggag cttagacggg aatgcatgga agaacttgga gacgcccttg 4500 tggcctccca gattttccat acattcgtcc atgatgatgg caatgggccc gtgggaagct 4560 gcctgagcaa aaacgtttct gggatcgctc acatcgtagt tatgttccag ggtgaggtca 4620 tcataggaca tctttacgaa tcgggggcgg agggtcccgg actgggggat gatggtaccc 4680 tcgggccccg gggcgtagtt cccctcacag atctgcatct cccaggcttt catttcagag 4740 ggagggatca tatccacctg cggggcgatg aaaaagacag tttctggcgc aggggagatt 4800 aactgggatg agagcaggtt tctgagcagc tgtgactttc cacagccggt gggcccatat 4860 atcacgccta tcaccggctg cagctggtag ttaagagagc tgcagctgcc gtcctcccgg 4920 agcagggggg ccacctcgtt gagcatatcc ctgacgtgga tgttttccct gaccagttcc 4980 gccagaaggc gctcgccgcc cagcgaaagc agctcttgca aggaagcaaa atttttcagc 5040 ggtttcaggc catcggccgt gggcatgttt ttcagcgtct gggtcagcag ctccagcctg 5100 tcccagagct cggtgatgtg ctctacggca tctcgatcca gcagatctcc tcgtttcgcg 5160 ggttggggcg gctttcgctg tagggcacca gccgatgggc gtccagcggg gccagagtca 5220 tgtccttcca tgggcgcaga gtcctcgtca gggtggtctg ggtcacggtg aaggggtgcg 5280 ctccgggttg ggcgctggcc agggtgcgct tgaggctggt tctgctggtg ctgaatcgct 5340 gccgctcttc gccctgcgcg tcggccaggt agcatttgac catggtctcg tagtcgagac 5400 cctcggcggc gtgccccttg gcgcggagct ttcccttgga ggtggcgccg cacgaggggc 5460 actgcaggct cttcagggcg tagagcttgg gagcgagaaa cacggactct ggggagtagg 5520 cgtccgcgcc gcaggccgag cagaccgtct cgcattccac cagccaagtg agttccgggc 5580 ggtcagggtc aaaaaccagg ctgcccccat gctttttgat gcgtttctta cctcggctct 5640 ccatgaggcg gtgtcccttc tcggtgacga agaggctgtc cgtgtccccg tagaccgatt 5700 tcaggggcct gtcttccagc ggagtgcctc tgtcctcctc gtagagaaac tctgaccact 5760 ctgagacaaa ggcccgtgtc caggccagga cgaaggaggc cacgtgggag gggtagcggt 5820 cgttgtccac tagcgggtcc accttctcca gggtgtgcag gcacatgtcc ccctcctccg 5880 cgtccagaaa agtgattggc ttgtaggtgt aggacacgtg accgggggtt cccgacgggg 5940 gggtataaaa gggggtgggt gccctttcat cttcactctc ttccgcatcg ctgtctgcga 6000 gagccagctg ctggggtaag tattcccttt cgaaggcggg catgacctca gcgctcaggt 6060 tgtcagtttc taaaaatgag gaagatttga tgttcacctg tccggaggtg atacctttga 6120 gggtacctgg gtctatctgg tcagaaaaca ctattttttt gttatcaagc ttggtggcga 6180 acgacccgta gagggcgttg gagagcagct tggcgatgga gcgcagggtc tggtttttgt 6240 cgcggtcggc tcgctccttg gccgcgatgt tgagttgcac gtactcgcgg gccacgcact 6300 tccactcggg gaagacggtg gtgcgctcgt ctgggatcag gcgcaccctc cagccgcggt 6360 tgtgcagggt gaccatgtcg acgctggtgg cgacctcacc gcgcaggcgc tcgttggtcc 6420 agcagaggcg gccgcccttg cgcgagcaga aggggggtag ggggtccagc tggtcctcgt 6480 tcggggggtc cgcgtcgatg gtaaagaccc cggggagcag acgcgggtca aagtagtcga 6540 tcttgcaagc ttgcatgtcc agagcccgct gccattcgcg ggcggcgagc gcgcgctcgt 6600 aggggttgag gggcgggccc cagggcatgg ggtgggtgag cgcagaggcg tacatgccgc 6660 agatgtcata cacgtacagg ggttccctga ggatgccgag gtaggtgggg tagcagcgcc 6720 ccccgcggat gctggcgcgc acgtagtcat agagttcgtg ggagggggcc agcatgttgg 6780 gcccgaggtt ggtgcgctgg gggcgctcgg cgcggaagac gatctgcctg aagatggcgt 6840 gggagttgga ggagatggtg ggccgctgga agacgttgaa gcttgcttct tgcaagccca 6900 cggagtccct gacgaaggag gcgtaggact cgcgcagctt gtgcaccagc tcggcggtga 6960 cctggacgtc gagcgcacag tagtcgaggg tctcacggat gatgtcatac ttatcctccc 7020 ccttcttttt ccacagctcg cggttgagga cgaactcttc gcggtctttc cagtactctt 7080 ggaggggaaa cccgtccgtg tccgaacggt aagagcctag catgtagaac tggttgacgg 7140 cctggtaggg gcagcagccc ttctccacgg gcagcgcgta ggcctgcgcc gccttgcgga 7200 gggaggtgtg ggtgagggcg aaagtgtccc tgaccatgac tttgaggtat tgatgtctga 7260 agtctgtgtc atcgcagccg ccctgttccc acagggtgta gtccgtgcgc tttttggagc 7320 gcgggttggg cagggagaag gtgaggtcat tgaagaggat cttccccgct cgaggcatga 7380 agtttctggt gatgcgaaag ggccctggga ccgaggagcg gttgttgatg acctgggcgg 7440 ccaggacgat ctcgtcaaag ccgtttatgt tgtggcccac gatgtagagc tccaggaagc 7500 ggggctggcc cttgatggag gggagctttt taagttcctc gtaggtgagc tcctcgggcg 7560 attccaggcc gtgctcctcc agggcccagt cttgcaagtg agggttggcc gccaggaagg 7620 atcgccagag gtcgcgggcc atgagggtct gcaggcggtc gcggaaggtt ctgaactgtc 7680 gccccacggc catcttttcg ggggtgatgc aatagaaggt gagggggtct ttctcccagg 7740 ggtcccatct gagctctcgg gcgaggtcgc gtgcggcggc gaccagagcc tcgtcgcccc 7800 ccagtttcat gaccagcatg aagggcacga gctgcttgcc aaaggctccc atccaagtgt 7860 aggtctctac atcgtaggtg acaaagaggc gctccgtgcg aggatgagag ccgatcggga 7920 agaactggat ctcccgccac cagttggagg attggctgtt gatgtggtga aagtagaagt 7980 cccgtctgcg ggccgagcac tcgtgctggc ttttgtaaaa gcgaccgcag tactggcagc 8040 gctgcacggg ttgtatatct tgcacgaggt gaacctggcg acctctgacg aggaagcgca 8100 gcgggaatct aagtcccccg cctggggtcc cgtgtggctg gtggtcttct actttggttg 8160 tctggccgcc agcatctgtc tcctggaggg cgatggtgga acagaccacc acgccgcgag 8220 agccgcaggt ccagatctcg gcgctcggcg ggcggagttt gatgacgaca tcgcgcacat 8280 tggagctgtc catggtctcc agctcccgcg gcggcaggtc agccgggagt tcctggaggt 8340 ttacctcgca gagacgggtc aacgcacggg cagtgttaag atggtatctg atttcaaggg 8400 gcgtgttggc ggcggagtcg atggcttgca ggaggccgca gccccggggg gccacgatgg 8460 ttccccgtgg ggcgcgaggg gaggcggaag ctgggggtgt gttcagaagc ggtgacgcgg 8520 gcgggccccc ggaggtaggg ggggttccgg ccccacaggc atgggcggca ggggcacgtc 8580 ttcgccgcgc gcgggcaggg gctggtgctg gctccgaaga gcgcttgcgt gcgcgacgac 8640 gcgacggttg gtgtcctgta tctggcgcct ctgagtgaag accacgggtc ccgtgacctt 8700 gaacctgaaa gagagttcga cagaatcaat ctcggcatcg ttgacagcgg cctggcgcag 8760 gatctcctgc acgtcgcccg agttgtcctg gtaggcgatc tctgccatga actgctcgat 8820 ctcttcctcc tggagatctc ctcgtccggc gcgctccacg gtggccgcca ggtcgttgga 8880 gatgcgaccc atgagctgcg agaaggcgtt gagtccgccc tcgttccaga cccggctgta 8940 gaccacgccc ccctcggcgt cgcgggcgcg catgaccacc tgggccaggt tgagctccac 9000 gtgtcgcgtg aagacggcgt agttgcgcag gcgctggaaa aggtagttca gggtggtggc 9060 ggtgtgctcg gcgacaaaga agtacatgac ccagcgccgc aacgtggatt cattgatgtc 9120 ccccaaggcc tccaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 9180 ggagttgcga gcggacacgg tcaactcctc ctccagaaga cggatgagct cggcgacagt 9240 gtcgcgcacc tcgcgctcga aggccacggg gggcgcttct tcctcttcca cctcttcttc 9300 catgattgct tcttcttctt cctcagccgg gacgggaggg ggcggcggcg ggggaggggc 9360 gcggcggcgg cggcggcgca ccgggaggcg gtcgatgaag cgctcgatca tctccccccg 9420 catgcggcgc atggtctcgg tgacggcgcg gccgttctcc cgggggcgca gctcgaagac 9480 gccgcctttc atctcgccgc ggggcgggcg gccgtgaggt agcgagacgg cgctgactat 9540 gcatcttaac aattgctgtg taggtacgcc gccaagggac ctgattgagt ccagatccac 9600 cggatccgaa aacctttgga ggaaagcgtc tatccagtcg cagtcgcaag gtaggctgag 9660 caccgtggcg ggcgggggcg ggtcgggaga gttcctggcg gagatgctgc tgatgatgta 9720 attaaagtag gcggtcttga gaaggcggat ggtggacagg agcaccatgt ctttgggtcc 9780 ggcctgttgg atgcggaggc ggtcggccat gccccaggcc tcgttctgac accggcgcag 9840 gtctttgtag tagtcttgca tgagtctttc caccggcacc tcttctcctt cctcttctcc 9900 atctcgccgg tggtttctcg cgccgcccat gcgcgtgacc ccaaagcccc tgagcggctg 9960 cagcagggcc aggtcggcga ccacgcgctc ggccaagatg gcctgctgta cctgagtgag 10020 ggtcctctcg aagtcatcca tgtccacgaa gcggtggtag gcgcccgtgt tgatggtgta 10080 ggtgcagttg gccatgacgg accagttgac ggtctggtgt cccggctgcg agagctccgt 10140 gtaccgcagg cgcgagaagg cgcgggaatc gaacacgtag tcgttgcaag tccgcaccag 10200 atactggtag cccaccagga agtgcggcgg aggttggcga tagaggggcc agcgctgggt 10260 ggcgggggcg ccgggcgcca ggtcttccag catgaggcgg tggtatccgt agatgtacct 10320 ggacatccag gtgatgccgg cggcggtggt ggtggcgcgc gcgtagtcgc ggacccggtt 10380 ccagatgttt cgcaggggcg agaagtgttc catggtcggc acgctctggc cggtgaggcg 10440 cgcgcagtcg ttgacgctct atacacacac aaaaacgaaa gcgtttacag ggctttcgtt 10500 ctgtagcctg gaggaaagta aatgggttgg gttgcggtgt gccccggttc gagaccaagc 10560 tgagctcggc cggctgaagc cgcagctaac gtggtattgg cagtcccgtc tcgacccagg 10620 ccctgtatcc tccaggatac ggtcgagagc ccttttgctt tcttggccaa gcgcccgtgg 10680 cgcgatctgg gatagatggt cgcgatgaga ggacaaaagc ggctcgcttc cgtagtctgg 10740 agaaacaatc gccagggttg cgttgcggcg taccccggtt cgagccccta tggcggcttg 10800 gatcggccgg aaccgcggct aacgtgggct gtggcagccc cgtcctcagg accccgccag 10860 ccgacttctc cagttacggg agcgagcccc ttttgttttt tattttttag atgcatcccg 10920 tgctgcggca gatgcgcccc tcgccccggc ccgatcagca gcagcaacag caggcatgca 10980 gacccccctc tcctctcccc gccccggtca ccacggccgc ggcggccgtg tccggcgcgg 11040 ggggtgcgct ggagtcagat gagccaccgc ggcggcgacc taggcagtat ctggacttgg 11100 aagagggcga gggactggcg cggctggggg cgagctcccc agagcgtcac ccgcgggtgc 11160 agttgaaaag ggacgcgcgc gaggcgtacc tgccgcggca aaacctgttt cgcgaccgcg 11220 ggggcgagga gcccgaggag atgcgagact gcaggttcca agcagggcgc gagctgcgcc 11280 gcggcttgga cagagagcgc ttgctgcgcg aggaggactt tgagcccgac acgcagacgg 11340 gcatcagccc cgcgcgcgcg cacgtggccg cggccgacct ggtgaccgcc tacgagcaga 11400 cggtgaacca ggagcgcaac ttccaaaaaa gcttcaacaa ccacgtgcgc acgctggtgg 11460 cgcgcgagga ggtgaccctg ggtctcatgc atctgtggga cctggtggag gcgatcgtgc 11520 agaaccccag cagcaagccc ctgaccgcgc agctgttcct ggtggtgcag cacagcaggg 11580 acaacgatgc cttcagggag gcgctgctga acatcaccga gccggagggg cgctggctcc 11640 tggacctgat aaacatcctg cagagcatag tggtgcagga gcgcagcctg agcctggccg 11700 agaaggtggc ggccattaac tattctatgc tgagcctggg caagttctac gcccgcaaga 11760 tctacaagac cccctacgtg cccatagaca aggaggtgaa gatagacagc ttctacatgc 11820 gcatggcgct aaaggtgctg accctgagcg acgacctggg agtgtaccgc aacgagcgca 11880 tccacaaggc cgtgagcgcc agccggcggc gcgagctgag cgaccgcgag ctgatgcaca 11940 gtctgcaacg cgcgctgacc ggcgcgggcg agggcgacag ggaggtcgag tcctacttcg 12000 acatgggggc cgacctgcac tggcagccga gccgccgcgc cctggaggcg gcgggggcgt 12060 atggcggccc cctggcggcc gatggcgagg aagaggagga ctatgagcta gaggagggcg 12120 agtacctgga ggactgacct ggctggtggt gttttggtat agatgcaaga tccgaacgtg 12180 gcggacccgg cggtccgggc ggcgctgcag agccagccgt ccggcattaa ctcctctgac 12240 gactgggccg cggccatggg tcgcatcatg gccctgaccg cgcgcaaccc cgaggccttc 12300 aggcagcagc ctcaggctaa ccggctggcg gccatcttgg aagcggtagt gcccgcgcgc 12360 tccaacccca cccacgagaa ggtgctggcc atagtcaacg cgctggcgga gagcagggcc 12420 atccgggcgg acgaggccgg actggtgtac gatgcgctgc tgcagcgggt ggcgcggtac 12480 aacagcggca acgtgcaaac caacctggac cgcctggtga cggacgtgcg cgaggccgtg 12540 gcgcagcgcg agcgcttgca tcaggacggt aacctgggct cgctggtggc gctaaacgcc 12600 ttcctcagca cccagccggc caacgtaccg cgggggcagg aggactacac caacttcttg 12660 agcgcgctgc ggctgatggt gaccgaggtc cctcagagcg aagtgtacca gtcggggccc 12720 gactacttct tccagaccag cagacagggc ttgcaaaccg tgaacctgag ccaggctttc 12780 aagaacctgc gggggctgtg gggagtgaag gcgcccaccg gcgaccgggc tacggtgtcc 12840 agcctgctaa cccccaactc gcgcctgctg ctgctgctga tcgcgccctt cacggacagc 12900 gggagcgtct cgcgggagac ctatctgggc cacctgctga cgctgtaccg cgaggccatc 12960 gggcaggcgc aggtggacga gcacaccttc caggagatca ccagcgtgag ccacgcgctg 13020 gggcaggagg acacgggcag cctgcaggcg accctgaact acctgctgac caacaggcgg 13080 cagaagattc ccacgctgca cagcctgacc caggaggagg agcgcatctt gcgctacgtg 13140 cagcagagcg tgagcctgaa cctgatgcgc gacggcgtga cgcccagcgt ggcgctggac 13200 atgaccgcgc gcaacatgga accgggcatg tacgcttccc agcggccgtt catcaaccgc 13260 ctgatggact acttgcatcg ggcggcggcc gtgaaccccg agtacttcac caatgccatt 13320 ctgaatcccc actggatgcc ccctccgggt ttctacaacg gggactttga ggtgcccgag 13380 gtcaacgacg ggttcctctg ggatgacatg gatgacagtg tgttctcccc caacccgctg 13440 cgcgccgcgt ctctgcgatt gaaggagggc tctgacaggg aaggaccgag gagtttggcc 13500 tcctccctgg ctctgggggc ggtgggcgcc acgggcgcgg cggcgcgggg cagcagcccc 13560 ttccccagcc tggcggactc tctgaatagc gggcgggtga gcaggccccg cttgctaggc 13620 gaggaggagt atctgaacaa ctccctgcta cagcccgtga gggacaaaaa cgctcagcgg 13680 cagcagtttc ccaacaacgg gatagagagc ctggtggaca agatgtccag atggaagacg 13740 tatgcgcagg agtacaagga gtgggaggac cgacagccgc ggcccctgcc gccccctaga 13800 cagcgctggc agcggcgtgc gtccaaccgc cgctggaggc aggggcccga ggacgatgat 13860 gactctgcag atgacagcag cgtgttggat ctgggcggga gcgggaaccc cttttcgcac 13920 ctgcgcccac gcctgggcaa gatgttttaa aagagaaaaa taaaaactca ccaaggccat 13980 ggcgacgagc gttggttttt ttgttccctt ccttagtatg cggcgcgcgg cgatgttcga 14040 ggaggggcct cccccctctt acgagagcgc gatgggaatt tctcctgcgg cgcccctgca 14100 gcctccctac gtgcctcctc ggtacctgca acctacaggg gggagaaata gcatctgtta 14160 ctctgagctg cagcccctgt acgataccac cagactgtac ctggtggaca acaagtccgc 14220 ggacgtggcc tccctgaact accagaacga ccacagcgat tttttgacca cggtgatcca 14280 aaacaacgac ttcaccccaa ccgaggccag tacccagacc ataaacctgg acaacaggtc 14340 gaactggggc ggcgacctga agactatcct gcacaccaat atgcccaacg tgaacgagtt 14400 catgttcacc aactctttta aggcgcgggt gatggtggcg cgcgagcagg gggaggcgaa 14460 gtacgagtgg gtggacttca cgctgcccga gggcaactat tcagagacca tgactctcga 14520 cctgatgaac aatgcgatcg tggaacacta tctgaaagtg ggcaggcaga acggggtgaa 14580 ggagagcgat atcggggtca agtttgacac cagaaacttt cgtctgggct gggaccccgt 14640 gaccgggctg gtcatgccgg gggtctacac caacgaggcc tttcatcccg atatagtgct 14700 cctgcccggc tgtggggtgg actttaccca gagccggctg agcaacctgc tgggcgttcg 14760 caagcggcaa cctttccagg agggtttcaa gatcacctat gaggatctgg aggggggcaa 14820 cattcccgcg ctccttgatc tggacgccta cgaggagagc ttgaaacccg aggagagcgc 14880 tggcgacagc ggcgagagtg gcgaggagca agccggcggc ggtggcagcg cgtcggtaga 14940 aaacgaaagt actcccgcag tggcggcgga cgctgcggag gtcgagccgg aggccatgca 15000 gcaggacgca gaggagggcg cgcaggagga catgaacaat ggggagatca ggggcgacac 15060 tttcgccacc cggggcgaag aaaaagaggc agaggcggcg gcggcgacgg cggaagccga 15120 aaccgaggca gaggcagagc ccgagaccga agttatggaa gacatgaatg atggagaacg 15180 taggggtgac acgtttgcca cccggggcga agagaaggcg gcggaggcag aagccgcggc 15240 tgaggaggcg gctgcggctg cggccaaggc tgaggctgcg gctgaggcta aggtcgaagc 15300 cgatgttgcg gttgaggctc aggctgagga ggaggcggcg actgaagcag ttaaggaaaa 15360 ggcccaggca gagcaggaag agaaaaaacc tgtcattcaa cctctaaaag aagatagcaa 15420 aaagcgcagt tacaacgtca tcgagggcag cacctttacc caataccgca gctggtacct 15480 ggcttacaac tacggcgacc cggtcaaggg ggtgcgctcg tggaccctgc tctgcacgcc 15540 ggacgtcacc tgcggctccg agcagatgta ctggtcgctg ccaaacatga tgcaagaccc 15600 ggtgaccttc cgttccacgc ggcaggttag caactttccg gtggtgggcg ccgaactgct 15660 gccagtgcac tccaagagtt tttacaacga gcaggccgtc tactcccagc tgatccgcca 15720 ggccacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc 15780 gccggccccc accatcacca ccgtcagtga aaacgttcct gccctcacag atcacgggac 15840 gctaccgctg cgcaacagca tctcaggagt ccagcgagtg accattactg acgccagacg 15900 ccggacctgc ccctacgttt acaaggcctt gggcatagtc tcgccgcgcg tcctctccag 15960 tcgcactttt taaaacacat ctaccctcac gctccaaaat catgtccgta ctcatctcgc 16020 ccagcaacaa caccggctgg gggctgcgcg cgcccagcaa gatgtttgga ggggcgagga 16080 aacgctccga acagcaccca gtgcgcgtgc gcggccacta ccgcgcgccc tggggtgcgc 16140 acaagcgcgg gcgcacaggg cgcaccactg tggatgatgt cattgactcc gtagtggagc 16200 aggcgcgcca ctacacaccc ggcgcgccga ccgcctccgc cgtgtccacc gtggaccagg 16260 cgatcgaaag cgtggtacag ggggcgcggc actatgccaa ccttaaaagt cgccgccgcc 16320 gcgtggcgcg ccgccatcgc cggagacccc gggctactgc cgccgcgcgc cttaccaagg 16380 ctctgctcaa gcgcgccagg cgaactggcc accgggccgc catgagggcc gcacggcggg 16440 ctgccgctgc cgcgagcgcc gtggccccgc gggcacgaag gcgcgcggcc gctgccgccg 16500 ccgccgccat ttccagcttg gcctcgacgc ggcgcggtaa catatactgg gtgcgcgact 16560 cggtaagcgg cacacgggtg cccgtgcgct ttcgcccccc acggaattag cacaaaacaa 16620 catacacact gagtctcctg ctgttgtgta tcccagcggc gaccgtcagc agcggcgaca 16680 tgtccaagcg caaaattaaa gaagagatgc tccaggtcat cgcgccggag atctatgggc 16740 ccccgaagaa ggaggaggat gattacaagc cccgcaagct aaagcgggtc aaaaagaaaa 16800 agaaagatga tgacgttgac gaggcggtgg agtttgtccg ccgcatggcg cccaggcgcc 16860 ccgtgcagtg gaagggtcgg cgcgtgcagc gagtcctgcg ccccggcacc gcggtggtct 16920 ttacgcccgg cgagcgttcc acgcgcactt tcaagcgggt gtacgatgag gtgtacggcg 16980 acgaggatct gttggagcag gccaaccatc gctttgggga gtttgcatat gggaaacggc 17040 cccgcgagag cctaaaagag gacctgctgg cgctaccgct ggacgagggc aatcccaccc 17100 cgagtctgaa gccggtaacc ctgcaacagg tgctgccttt gagcgcgccc agcgagcaga 17160 agcgagggtt gaagcgcgag ggcggggacc tggcacccac cgtgcagttg atggtgccca 17220 agcggcagaa gctggaggac gtgctggaga aaatgaaagt agagcccggg atccagcccg 17280 aaatcaaggt ccgccccatc aagcaggtgg cgcccggcgt gggagtccag accgtggacg 17340 ttaggattcc cacggaggag atggaaaccc aaaccgccac tccctcttcg gcggctagcg 17400 ccaccaccgg cgccgcttcg gtagaggtgc agacggaccc ctggctacct gccgccactg 17460 tcgccgccgc cgccgccgcc ccccgttcgc gcgggcgcaa gagaaattat ccagcggcca 17520 gcgcgctcat gccccagtac gcactgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcacccgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcattg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg cctccgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcagag gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgctg 17940 cccttcctaa tcccgctaat cgccgcggcg atcggtgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc attttttgga 18060 ggaaaaaata aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagt ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggccaga tgctgagaga caagttgaaa gagcagaact tccaggaaaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccggcctcag gtggaggaaa cgcctccagc 18480 aatggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcctaccact cgccccatag cccccatggc caccggtgtg gtgggacaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgatccgcct cgccagccaa aggcggcgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgccc ctgcgccgcg ctgcaagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gtttatcccc gtggatcggg 19200 aggacaccgc ctactcttac aaggcgcggt ttacgctggc cgtgggcgac aatcgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggagg ctgcagatga ggacgtcgaa gatgaagaag 19440 cgcaagcaca agaggaagcc cctgttaaaa aaattcatgt atatgctcag gcgcctcttg 19500 ctggcgaaaa gattaccaag gatggtttgc aaataggtac tgaagtcgta ggagagacat 19560 ctaaggacac ttttgcagat aaaacattcc aacccgaacc tcagataggc gagtctcagt 19620 ggaacgaggc tgatgccgca gtagcaggag gtagagtttt gaaaaagact acccctatga 19680 gaccttgcta tggatcctat gccaggccta ccaatgccaa cgggggtcaa ggaattctgg 19740 ttgccaatga acaaggagtg atggagtcta aagtagaaat gcaatttttc tctaacacct 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtacagcg 19860 aagatgtcca cttggaatct cccgatactc atctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa agtcatgttg ggtcagcaag ccatgcccaa cagacccaac ctcattggat 19980 ttagagataa tttcattggg cttatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaggc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 catatcagct tatgcttgat tcaattgggg atagaaccag atacttctcc atgtggaacc 20160 aggcagtgga tagctatgat ccagatgtca gaattattga aaaccatggg gttgaggatg 20220 aactgcccaa ctactgcttc cctttgggcg gcataggaat tactgatact tatcaagggg 20280 tgaaaaatac caatggcaat ggtcagtgga ccaaagatga tcagttcgcg gaccgcaacg 20340 aaataggggt gggaaacaac ttcgccatgg agatcaacat ccaggccaac ctttggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcgcc caccatgcgc gagggtcagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac tttcgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgcctgca tgactggttc caccgagcaa gagctcaggg 21900 ccatcgccag agacctggga tgcggaccct actttttggg cacctatgac aaacgcttcc 21960 cgggtttcat ctcccgagac aagctcgcct gcgccatcgt caacacggcc gcgcgcgaga 22020 ccgggggcgt gcactggctg gcctttggct gggacccgcg ctctaaaact tgctacctct 22080 ttgacccctt tggcttctct gatcagcgcc tcaggcagat ttatgagttt gagtacgagg 22140 ggctgctgcg ccgcagcgcg cttgcctcct cgcccgaccg ctgcatcacc cttgagaagt 22200 ccaccgagac cgtgcagggg ccccactcgg ccgcctgcgg tctcttctgt tgcatgtttt 22260 tgcacgcctt tgtacactgg cctcagagtc ccatggatcg caaccccacc atgaacttgc 22320 taaagggagt gcccaacgcc atgctccaga gcccccaggt cctgcccacc ctgcgccgca 22380 accaggaaca gctctaccgc ttcctggagc gccactcccc ctacttccgc agccacagcg 22440 cgcgcatccg gggggccacc tctttttgcc acttgcaaga aaacatgcaa gacggaaaat 22500 gatgtacagc atgcttttaa taaatgtaaa gactgtgcac tttatttata cacgggctct 22560 ttctggttat ttattcaaca ccgccgtcgc catctagaaa tcgaaagggt tctgccgcgc 22620 gtcgccgtgc gccacgggca gagacacgtt gcgatactgg aagcggctcg cccacttgaa 22680 ctcgggcacc accatgcggg gcagtggttc ctcggggaaa ttctcgctcc acagggtgcg 22740 ggtcagctgc agcgcgctca ggaggtcggg agccgagatc ttgaagtcgc agttggggcc 22800 ggaaccctgc gcgcgcgagt tgcggtacac ggggttgcag cactggaaca ccagcagggc 22860 cggattattc acgctggcca gcaggctctc gtcgctgatc atgtcgctgt ccagatcctc 22920 cgcgttgctc agggcgaatg gggtcatctt gcagacctgc ctgcccagga aaggcgggag 22980 cccaggcttg ccgttgcagt cgcagcgcag gggcattagc aggtgcccac ggcccgactg 23040 cgcctgcggg tacaacgcgc gcatgaaggc ttcgatctgc ctaaaagcca cctgggtctt 23100 ggctccctcc gaaaagaaca tcccacagga cttgctggag aactgattcg cgggacagct 23160 ggcatcgtgc aggcagcagc gcgcgtcagt gttggcgatc tgcaccacgt tgcgacccca 23220 ccggtttttc actatcttgg ccttggaagc ctgctccttt agcgcgcgct ggccgttctc 23280 gctggtcaca tccatctcta tcacctgttc cttgttgatc atgtttgtcc cgtgcagaca 23340 ctttaggtcg ccctccgtct gggtgcagcg gtgctcccac agcgcgcaac cggtgggctc 23400 ccaattcttg tgggtcaccc ccgcgtaggc ctgcaggtag gcctgcagga agcgccccat 23460 catggtcata aaggtcttct ggctcgtaaa ggtcagctgc aggccgcgat gctcttcgtt 23520 cagccaggtc ttgcagatgg cggccagcgc ctcggtctgc tcgggcagca tcttaaaatt 23580 tgtcttcagg tcgttatcca cgtggtactt gtccatcatg gcacgcgccg cctccatgcc 23640 cttctcccag gcggacacca tgggcaggct tagggggttt atcacttcca gcggcgagga 23700 caccgtactt tcgatttctt cttcctcccc ctcttcccgg cgcgcgcccc cgctgttgcg 23760 cgctcttacc gcctgcacca aggggtcgtc ttcaggcaag cgccgcaccg agcgcttgcc 23820 gcccttgacc tgcttgatca gtaccggcgg gttgctgaag cccaccatag tcagcgccgc 23880 ctgctcttct tcgtcttcgc tgtctaccac tatttctggg gaggggcttc tccgctctgc 23940 ggcaaaggcg gcggatcgct tctttttttt cttgggagcc gccgcgatgg agtccgccac 24000 ggcgaccgag gtcgagggcg tggggctggg ggtgcgcggc accagggcct cgtcgccctc 24060 ggactcttcc tctgactcca ggcggcggcg gagtcgcttc tttgggggcg cgcgcgtcag 24120 cggcggcgga gacggggacg gggacgggga cgggacgccc tccacagggg gcggtcttcg 24180 cgcagacccg cggccgcgct cgggggtctt ctcgcgctgg tcttggtccc gactggccat 24240 tgtatcctcc tcctcctagg cagagagaca taaggagtct atcatgcaag tcgagaagga 24300 ggagagctta accaccccct ctgagaccgc cgtcgccgtc gcccccgcta ccgccgacgc 24360 gcccgccaca ccgagcgaca cccccgcgga cccccccgcc gacgcacccc tgttcgagga 24420 agcggccgtg gagcaggacc cgggctttgt ctcggcagag gaggatttgc aagaggagga 24480 ggataaggag gagaagccct cagtgccaaa agatcataaa gagcaagacg agcacgacgc 24540 agacgcacac cagggtgaag tcgggcgggg ggacggaggg catggcggcg ccgactacct 24600 agacgaagga aacgacgtgc tcttgaagca cctgcatcgt cagtgcgcca tcgtctgcga 24660 cgctctgcag gagcgcagcg aggtgcccct cagcgtggcg gaggtcagcc gcgcctacga 24720 gctcagcctc ttttcccccc gggtgccccc ccgccgccgc gaaaacggca catgcgagcc 24780 caacccgcgc ctcaacttct accccgcctt tgtggtgccc gaggtcctgg ccacctatca 24840 catcttcttt caaaattgca agatccccat ctcgtgccgc gccaaccgta gccgcgccga 24900 taagatgctg gccctgcgcc agggcgacca catacctgat atcgccgctt tggaagatgt 24960 accaaagatc ttcgagggtc tgggtcgcaa cgaaaagcgg gcagcaaact ctctgcaaca 25020 ggaaaacagc gaaaatgaga gtcacaccgg ggtgctggtg gagctcgagg gcgacaacgc 25080 ccgcctggcg gtgctcaagc gcagcatcga ggtcacccac tttgcctacc ccgcgctcaa 25140 cctgcccccc aaagtcatga acgcggtcat ggacgggctg atcatgcgcc gcggccagcc 25200 ccttgctcca gatgcaaact tgcatgagga gaccgaggac ggccagcccg tggtcagcga 25260 cgagcagctg gcgcgctggc tggaaaccgc ggaccccgcc gaactggagg agcggcgcaa 25320 gatgatgatg gccgcggtgc tggtcaccgt agagctggag tgtctgcagc gcttcttcgg 25380 tgaccccgag atgcagagaa aggtcgagga gaccctacac tacaccttcc gccagggcta 25440 cgtgcgccag gcttgcaaga tctccaacgt ggagctcagc aacctggtgt cctacctggg 25500 catcttgcat gagaaccgcc ttgggcagag cgtgctgcac tccaccctgc gcggggaagc 25560 gcgccgcgac tacgtgcgcg actgcgttta ccttttcctc tgctacacct ggcagacggc 25620 catgggggtc tggcagcagt gcctggagga gcgcaacctc aaggagctgg agaagctcct 25680 gcagcgcgcg ctcaaagacc tctggacggg cttcaacgag cgctcggtgg ccgccgcgct 25740 ggccgacctc atcttccccg agcgcctgct caaaactctc cagcaggggc tgcccgactt 25800 caccagccaa agcatgttgc aaaactttag gaactttatc ctggagcgtt ctggcatcct 25860 acccgccacc tgctgcgccc tgcccagtga ctttgttccc ctcgtgtacc gcgagtgccc 25920 cccgccgctg tggggccact gctacctgtt ccaactggcc aactacctgt cctaccacgc 25980 ggacctcatg gaggactcca gcggcgaggg gctcatggag tgccactgcc gctgcaacct 26040 ctgcacgccc caccgctccc tggtctgcaa cacccaactg ctcagcgaga gtcagattat 26100 cggtaccttc gagctacagg gtccgtcctc ctcagacgag aagtccgcgg ctccggggct 26160 aaaactcact ccggggctgt ggacttccgc ctacctgcgc aaatttgtac ctgaagacta 26220 ccacgcccac gagatcaggt tttacgagga ccaatcccgc ccgcccaagg cggagctgac 26280 cgcctgcgtc atcacccagg gcgagatcct aggccaattg caagccatcc aaaaagcccg 26340 ccaagagttt ttgctgagaa agggtcgggg ggtgtatctg gacccccagt cgggtgagga 26400 gctcaacccg gttcccccgc tgccgccgcc gcgggacctt gcttcccagg ataagcatcg 26460 ccatggctcc cagaaagaag cagcagcggc cgccactgcc gccaccccac atgctggagg 26520 aagaggagta ctgggacagt caggcagagg aggtttcgga cgaggaggag ccggagacgg 26580 agatggaaga gtgggaggag gacagcttag acgaggaggc ttccgaagcc gaagaggcag 26640 gcgcaacacc gtcaccctcg gccgcagccc cctcgcaggc gcccccgaag tccgctccca 26700 gcatcagcag caacagcagc gctataacct ccgctcctcc accgccgcga cccacggccg 26760 accgcagacc caaccgtaga tgggacacca ccggaaccgg ggccggtaag tcctccggga 26820 aaggcaagca agcgcagcgc caaggctacc gctcgtggcg cgctcacaag aacgccatag 26880 tcgcttgctt gcaagactgc ggggggaaca tctccttcgc ccgccgcttc ctgctcttcc 26940 accacggtgt ggccttcccc cgtaacgtcc tgcattacta ccgtcatctc tacagcccct 27000 actgcggcgg cagtgagcca gaggcggccg gcggcagcgg cgcccgtttc ggtgcctagg 27060 aagacccagg gcaagacttc agccaagaaa ctcgcggcgg ccgcggcgaa cgcggtcgcg 27120 ggggccctgc gcctgacggt gaacgaaccc ctgtcgaccc gcgaactgag gaaccgaatc 27180 ttccccactc tctatgccat cttccagcag agcagagggc aggatcagga actgaaagta 27240 aaaaacaggt ctctgcgctc cctcacccgc agctgtctgt atcacaagag cgaagaccag 27300 cttcggcgca cgctggagga cgctgaggca ctcttcagca aatactgcgc gctcactctt 27360 aaggactagc tccgcgccct tctcgaattt aggcgggaac gcctacgtca tcgcagcgcc 27420 gccgtcatga gcaaggacat tcccacgcca tacatgtgga gctatcagcc gcagatggga 27480 ctcgcggcgg gcgcctccca agactactcc acccgcatga actggctcag tgccggccca 27540 cacatgatct cacaggttaa tgacatccgc acccatcgaa accaaatatt ggtggagcag 27600 gcggcaatta ccaccacgcc ccgcaataat cccaacccca gggagtggcc cgcgtccctg 27660 gtgtatcagg aaattcccgg ccccaccacc gtactacttc cgcgtgattc ccaggccgaa 27720 gtccaaatga ctaactcagg ggcacagctc gcgggcggct gtcgtcacag ggtgcggcct 27780 cctcgccagg gtataactca cctggagatc cgaggcagag gtattcagct caacgacgag 27840 tcggtgagct cctcgctcgg tctcagacct gacgggacct tccagatagc cggagccggc 27900 cgatcttcct tcacgccccg ccaggcgtac ctgactctgc agagctcgtc ctcggcgccg 27960 cgctcgggcg gcatcgggac tctccagttc gtgcaggagt ttgtgccctc ggtctacttc 28020 aaccccttct cgggctctcc cggtcgctac ccggaccagt tcatcccgaa ctttgacgcc 28080 gcgagggact cggtggacgg ctacgactga atgtcgggtg gacccggtgc agagcaactt 28140 cgcctgaagc accttgacca ctgccgccgc cctcagtgct ttgcccgctg tcagaccggt 28200 gagttccagt acttttccct gcccgactcg cacccggacg gcccggcaca cggggtgcgc 28260 tttttcatcc cgagtcaggt ccgctctacc ctaatcaggg agtttacagc ccgtccccta 28320 ctggcggagt tggaaaaggg gccttctatc ctaaccattg cctgcatctg ctctaaccct 28380 ggattacacc aagatctttg ctgtcatttg tgtgctgagt ataataaagg ctgagatcag 28440 aatctactcg ggctcctgtc gccatcctgt caacgccacc gtccaagccc ggcccgatca 28500 gcccgaggtg aacctcacct gcggtctgca ccggcgcctg aggaaatacc tagcttggta 28560 ctacaacagc actccctttg tggtttacaa cagctttgac caggacgggg tctcactgag 28620 ggataacctc tcgaacctga gctactccat caggaagaac aacaccctcg agctacttcc 28680 tccttacctg cccgggactt accagtgtgt caccggtccc tgcacccaca cccacctgtt 28740 gatcgtaaac gactctcttc cgagaacaga cctcaataac tcctctccgc agttccccag 28800 aacaggaggt gagctcagga aaccccgggt aaagaagggt ggacaagagt taacacttgt 28860 ggggtttctg gtgtatgtga cgctggtggt ggctcttttg attaaggctt ttccttccat 28920 gtctgaactc tccctcttct tttatgaaca actcgactag tgctaacgag accctaccca 28980 acgaatcggg attgaatatc ggtaaccagg ttgcagtttc acttttgatt acctttatag 29040 tcctcttcct gctagtgctg tcgcttctgt gcctgcggat cgggggctgc tgcatccacg 29100 tttatatctg gtgctggctg tttagaaggt tcggagacca ccgcaggtag aataatgctg 29160 cttaccctct ttgtcctggc gctggctgcc agctgccaag ccttttccga ggctgacttc 29220 atagagcccc agtgcaatat cacttataaa tctgaacgtg ccatctgtac tatcctaatc 29280 aaatgtgtta ctcaacacga taaggtaact gttaaataca aagatcaatt aaaaaaagac 29340 gcactttaca gcagctggca accaggagat gaacaaaaat acaatgtaac cgtcttccag 29400 ggcaaactct ccaaaactta caattacact ttcccatttg agcagatgtg tgactttgtc 29460 atgtacatgg aaaagcagta caagctgtgg cctccaactc cccagggctg tgtggaaaat 29520 ccaggctctt tctgtatgat ctctctctgt gtaactgtgc tggcactaat actcacgctt 29580 ctgtatatca gatttaaatc aaggcaaagc tttattgatg aaaagaaaat gccttaatcg 29640 ctttcacgct tgattgctaa caccgggttt ttatccgcag aatgattgga atcaccctac 29700 taatcacctc cctccttgcg attgcccatg ggttggaacg aatcgaagtc cctgtggggg 29760 ccaatgttac cctggtgggg cctgtcggca atgctacatt aatgtgggaa aaatatacta 29820 aaaatcaatg ggtctcttac tgcactaaca aaaacagcca caagcccaga gccatctgcg 29880 atgggcaaaa tttaaccttg attgatgttc aattgctgga tgcgggctac tattatgggc 29940 agctgggtac aatgattaat tactggagac cccacagaga ttacatgctt cacgtagtaa 30000 agggtcccat tagcagccca accaccacct ctaccacccc cactaccacc actactccca 30060 ccaccagcac tgccgcccag cctcctcata gcagaacaac cacttttatc aattccaagt 30120 cccactcccc ccacattgcc ggcgggccct ccgcctcaga ctccgagacc accgagatct 30180 gcttctgcaa atgctctgac gccattgccc aggatttgga agatcacgag gaagatgagc 30240 atgactacgc agatgcatgc caggcatcag agtcagaagc gctgccggtg gccctaaaac 30300 agtatgcaga cccccacacc acccccgacc ttcctccacc ttcccagaag ccaagtttcc 30360 tgggggaaaa tgaaactctg cctctctcca tactagctct gacatctgtt gctattttgg 30420 ccgctctgct ggtgcttcta tgctctatat gctacctgat ctgctgcaga aagaaaaaat 30480 ctcacggcca tgctcaccag cccctcatgc acttccctta ccctccagag ctgggcgacc 30540 acaaacttta agtctgcagt agctatctgc ccatcccttg tcagtcgaca gcgatgagcc 30600 ccactaatct aacagcctct ggacttacaa cattgtctct taatgagacc accgctcctc 30660 aagacctgta cgatggtgtc tccgcgctgg ttaaccagtg ggatcacctg ggcatatggt 30720 ggctcctcat aggagcagtg accctgtgcc taatcctggt ctggatcatc tgctgcatca 30780 aaagcagaag acccaggcgg cggcccatct acaggccctt cgtcatcaca cctgaagata 30840 atgatgatga tgacaccacc tccaggctgc agagcctaaa gcagctactc ttctctttta 30900 cagcatggta aattgaatca tgccccgcat tttcatctac ttgcttctcc ttccactttt 30960 tctgggctcc tctacattgg ccgctgtgtc ccacatcgag gtagactgcc tcacgccctt 31020 cacagtctac ctgcttttcg gctttgtcat ctgcaccttt gtctgcagcg ttatcactgt 31080 agtgatctgc ttcatacagt gcatcgacta catctgtgtg cgggtggcct actttagaca 31140 ccacccccag tatcgcaaca gggacatagc ggctctccta agacttgttt aaatcatggc 31200 caaattacct gtgattggtc ttctgattat ctgctgcgtc ctagccgcga ttgggactca 31260 acctaatacc accaccagcg ctcccagaaa gagacatgta tcctgcagct tcaagcgtcc 31320 ctggaatata ccccaatgct ttactgatga acctgaaatc tctttggctt ggtacttcag 31380 cgtcaccgcc cttctcatct tctgcagtac ggttattgct cttgccatct acccttccct 31440 taacctgggc tggaatgctg tcaactctat ggaatatccc accttcccag aaccagacct 31500 gccagacctg gttgttctaa acgcgtttcc tcctcctcca gttcaaaatc agtttcgccc 31560 tccgtcccct acgcccactg aggtcagcta ctttaatcta acaggcggag atgactgaaa 31620 acctagacct agaaatggac ggtctctgca gcgagcaacg cacactagag aggcgccggc 31680 aaaaagcaga gctcgagcgt cttaaacaag agctccaaga cgccgtggcc atacaccagt 31740 gcaaaaaagg gctcttctgt ctggtaaaac aggccacgct cacctatgaa aaaacaggtg 31800 acacccaccg cctaggatac aagctgccca cacagcgcca aaagtttgcc cttatgatag 31860 gtgaacaacc catcaccgtc acccagcact ccgtggagac agaaggctgc attcatgctc 31920 cctgcagggg cgctgactgc ctctacacct tgatcaaaac cctctgcggt ctcagagacc 31980 ttatcccttt caattgatca taactgtaat caataaaaaa tcacttactt gaaatctgat 32040 agcaagcctc tgtccaattt tttcagcaac acttccttcc cctcttccca actctggtac 32100 tctaggcgcc tcctagctgc aaacttcctc cacagtctga agggaatgtc agattcctcc 32160 tcctcctgtc cctccgcacc cacaatcttc atgttgttgc agatgaaacg cgcgagatcg 32220 tctgacgaga ccttcaaccc cgtgtacccc tacgataccg agatcgctcc gacttctgtc 32280 cctttcctta cccctccctt tgtgtcaccc gcaggaatgc aagaaaatcc agctggggtg 32340 ctgtccctgc acctgtcaga gccccttacc acccacaatg gggccctgac tctaaaaatg 32400 gggggcggcc tgaccctgga caaggaaggg aatctcactt cccaaaacat caccagtgtc 32460 gatccccctc tcaaaaaaag caagaacaac atcagccttc agaccgccgc acccctcgcc 32520 gtcagctccg gggccctaac cctttttgcc actccccccc tagcggtcag tggcgacaac 32580 cttactgtgc agtctcaggc ccctcttact ttggaagact caaaactaac tctggccacc 32640 aaaggacccc taactgtgtc cgaaggcaaa cttgtcctag aaacagaggc tcccctgcat 32700 gcaagtgaca gcagtagcct gggccttagc gtcacggccc cacttagcat taacaatgac 32760 agcctaggac tagatctgca ggcacccatt gtctctcaaa atggaaaact ggctctaaat 32820 atagcaggcc ccctagctgt agccgatagc attaatgctt tgacagtagg cactggcaaa 32880 ggtattggac taaatgaaac cagcactcac ttgcaagcaa aattggttgc ccccctaggc 32940 tttgatacca atggcaatat taagctaagc gttgcaggag gcatgaggct aaacaatgac 33000 acactgatac tagatgtaaa ctacccattt gaagctcaag gtcaactaag cctaagagtg 33060 ggcacaggtc cactgtatgt agattctagc agtcataatc taaccattag atgccttagg 33120 ggattgtata taacatcatc taacaaccaa aacggtctag aggccaacat taaactaaca 33180 aaaggccttg tgtatgaagg aaatgccata gcagttaatg ttggtcaagg attgcaatac 33240 agcactactg ccacatcgga aggtgtgtat cctatacagt ctaagatagg tttgggaatg 33300 gaatatgata ccaacggagc catgatggca aaactaggct ccggtctaag ctttgataat 33360 tcaggagcca ttgtggtggg aaacaaaaat gatgacaaac ttaccctatg gaccacacct 33420 gacccgtctc ctaactgtag aatttattct gaaaaagata ctaaactaac cttggtgctg 33480 actaagtgtg gcagtcaaat cctaggcaca gtatctgccc ttgctgtcag aggcagcctt 33540 gcgcccatca ctaacgcatc cagcatagtc caaatatttc tacgatttga tgaaaatgga 33600 ctattgatga gcaactcatc gctagacggt gattactgga attacagaaa tggggactcc 33660 actaatggca caccatatac aaatgcagta ggctttatgc ctaatctagc tgcctatcct 33720 aaaggtcagg ctacaactgc aaaaagcagt attgtaagcc aggtatacat ggatggtgat 33780 actactaaac ctataacact aaaaataaac tttaatggca ttgatgaaac aacagaaaat 33840 acccctgtta gtaaatattc catgacattc tcatggagct ggcccaccgc aagctacata 33900 ggccacactt ttgcaacaaa ctcttttact ttctcctaca tcgcccaaga ataaagaaag 33960 cacagagatg cttgtttttg atttcaaaat tgtgtgcttt tatttatttt caagcttaca 34020 gtatttccag tagtcattca aatagagctt aatgaaactg catgagaacc cttccacata 34080 gcttaaatta tcaccagtgc aaatggagaa aaaatcaaca taccttttta tccagatatc 34140 atagaactct agtggtcagt tttcccccac cctcccagct cacagaatac acagtccttt 34200 ccccccggct ggctttaaac aacactatct cattggtaac agacatattc ttaggtgtaa 34260 taatccacac ggtctcttgg cgggccaaac gctggtcagt gatgttaata aactccccag 34320 gcagctcttt caagttcacg tcgctgtcca actgctgaag cgctcgcggc tccgactgcg 34380 cctctagcgg aggcaacggc aacacccgat ccttgatcta taaaggagta gagtcataat 34440 cccccataag aatagggcgg tgatgctgca acaaggcgcg cagcaactcc tgccgccgcc 34500 tttccgtacg acaggaatgc aacggggtgg tggtctcctc cgcgataatc cgcaccgctc 34560 gcaacatcag cgtcctcgtc ctccgggcac agcagcgcat cctgatctca ctgagatcgg 34620 cgcagtaagt gcagcacaac accaagatgt tatttaagat cccacagtgc aaagcactgt 34680 acccaaagct catggcggga aggacagccc ccacgtgacc atcataccag atcctcaggt 34740 aaatcaaatg acgacctctc atgaacacgc tggacatgta catcacctcc ttaggcatgt 34800 gctgattcac cacctctcga taccacaggc atcgctgatt aattaaagac ccctcgagca 34860 ccatcctgaa ccaggaagcc agcacctgac cccccgccag gcactgcagg gaccccggtg 34920 aatcgcagtg gcagtgaaga ctccagcgct cgtagccgtg aaccatagag ctggtcatta 34980 tatccacatt ggcacaacac agacacactt tcatacactt tttcatgatt agcagctcct 35040 ctctagtcag gaccatatcc caaggaatca cccactcttg aatcaaggta aatcccacac 35100 agcagggcag gcctctcaca taactcacgt tatgcatagt gagcgtgtcg caatctggaa 35160 ataccggatg atcttccatc accgaagccc gggtctccgt ctcaaaggga ggtaaacggt 35220 ccctcgtgta gggacagtgg cgggataatc gagatcgtgt tgaacgtaga gtcatgccaa 35280 agggaacagc ggacgtactc atatttcctc cagcagaacc aagtgcgcgc gtggcagcta 35340 tccttgcgtc ttctgtctcg ccgcctgccc cgctcggtgt agtagttgta atacagccac 35400 tccctcagac cgtcaaggcg ctccctggcg tccggatcta taacaacacc atcctgcagc 35460 gccgccctga tgacatccac caccgtagag tatgccaagc ccagccagga aatgcactca 35520 ctttgacagc gagagatagg aggagcggga agagatggaa gaaccatgat agtaaaagaa 35580 cttttattcc aatcgatcct ctacaatgtc aaagtgtaga tctatcagat ggcactggtc 35640 tcctccgctg agtcgatcaa aaataacagc taaaccacaa acaacacgat tggtcaaatg 35700 ctgcacaagg gcttgcagca taaaatcgcc tcgaaagtcc accgcaagca taacatcaaa 35760 gccaccgccc ctatcatgat ctatgataaa aaccccacag ctatccacca gacccatata 35820 gttttcatct ctccatcgtg aaaaaatatt tacaagctcc tcctttaaat cacctccaac 35880 caattcaaaa agttgagcca gaccgccctc caccttcatt ttcagcatgc gcatcatgat 35940 tgcaaaaatt caggctcctc agacacctgt ataagattga gaagcggaac gttaacatca 36000 atgtttcgct cgcgaagatc gcgcctcagt gcaagcatga tataatccca caggtcggag 36060 cggatcagcg aggacatctc cccgccagga accaactcaa cggagcctat gctgattata 36120 atacgcatat tcggggctat gctaaccagc acggccccca aataggcgta ctgcataggc 36180 ggcgacaaaa agtgaacagt ttgggttaaa aaatcaggca aacactcgcg caaaaaagca 36240 agaacatcat aaccatgctc atgcaaatag atgcaagtaa gctcaggaac gaccacagaa 36300 aaatgcacaa tttttctctc aaacatgact gcgagccctg caaaaataaa aaagaaacat 36360 tacacaagag tagcctgtct tacaatggga tagactactc taaccaacat aagacgggcc 36420 acaacatcgc ccgcgtggcc ataaaaaaaa ttatccgtgt gattaaaaag aagcacagat 36480 agctggccag tcatatccgg agtcatcacg tgcgaacccg tgtagacccc cgggttggac 36540 acatcggcca aacaaagaaa gcggccaatg tatcccggag gaatgataac actaagacga 36600 agatacaaca gaataacccc atggggggga ataacaaagt tagtaggtga ataaaaacga 36660 taaacacccg aaactccctc ctgcgtaggc aaaatagcgc cctccccttc caaaacaaca 36720 tatagcgctt ccacagcagc catgacaaaa gactcaaaac actcaaaaga ctcagtctta 36780 ccaggaaaat aaaagcactc tcacagcacc agcactaatc agagtgtgaa aaaggccaag 36840 tgccgaacga gtatatatag gaattaaaaa tgacgtaaat gtgtaaaggt cagaaaacgc 36900 ccagaaaaat acacagacca acgcccgaaa cgaaaacccg cgaaaaaata cccagaagtt 36960 cctcaacaac cgccacttcc gctttcccac gagacgtcac ttcctcaaaa atagcaaact 37020 acatttccca catatacaaa accaaaaccc ctccccttgt caccgcccac aacttacatc 37080 atcacaaacg tcaaagccta cgtcacccgc cccgcccacc tcattatcat attggccaca 37140 atccaaaata aggtatatta ttgatgatg 37169 <210> 5 <211> 37184 <212> DNA <213> Great Ape Adenovirus <400> 5 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggagg ctgcagatga ggacgtcgaa gatgaagaag 19440 cgcaagcaca agaggaagcc cctgttaaaa aaattcatgt atatgctcag gcgcctcttg 19500 ctggcgaaaa gattaccaag gatggtttgc aaataggtac tgaagtcgta ggagagacat 19560 ctaaggacac ttttgcagat aaaacattcc aacccgaacc tcagataggc gagtctcagt 19620 ggaacgaggc tgatgccgca gtagcaggag gtagagtttt gaaaaagact acccctatga 19680 gaccttgcta tggatcctat gccaggccta ccaatgccaa cgggggtcaa ggaattctgg 19740 ttgccaatga acaaggagtg atggagtcta aagtagaaat gcaatttttc tctaacacct 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtacagcg 19860 aagatgtcca cttggaatct cccgatactc atctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa agtcatgttg ggtcagcaag ccatgcccaa cagacccaac ctcattggat 19980 ttagagataa tttcattggg cttatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaggc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 catatcagct tatgcttgat tcaattgggg atagaaccag atacttctcc atgtggaacc 20160 aggcagtgga tagctatgat ccagatgtca gaattattga aaaccatggg gttgaggatg 20220 aactgcccaa ctactgcttc cctttgggcg gcataggaat tactgatact tatcaagggg 20280 tgaaaaatac caatggcaat ggtcagtgga ccaaagatga tcagttcgcg gaccgcaacg 20340 aaataggggt gggaaacaac ttcgccatgg agatcaacat ccaggccaac ctttggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcgcc caccatgcgc gagggtcagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac ttttgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgccgcct gcatgacggg ttccaccgag caagagctca 21900 gggccattgc cagagacctg ggatgcggac cctatttttt gggcacctat gacaaacgct 21960 tcccgggctt tatctcccga gacaagctcg cctgcgccat tgtcaacacg gccgcgcgcg 22020 agaccggggg cgtgcactgg ctggcctttg gctgggaccc gcgctccaaa acttgctacc 22080 tctttgaccc ctttggcttc tccgatcagc gcctcaggca gatttatgag tttgagtacg 22140 aggggctgct gcgccgcagc gcgctcgcct cctcgcccga ccgctgcatc acccttgaga 22200 agtccaccga aaccgtgcag gggccccact cggccgcctg cggtctcttc tgttgcatgt 22260 ttttgcacgc ctttgtgcac tggcctcaga gtcccatgga ttgcaacccc accatgaact 22320 tgctaaaggg agtgcccaac gccatgctcc agagccccca ggtccagccc accctgcgcc 22380 gcaaccagga acagctttac cgcttcctgg agcgccactc cccctacttc cgcagccaca 22440 gcgcgcgcat ccggggggcc acctcttttt gccacttgca agaaaacatg caagacggaa 22500 aatgatgtac agcatgcttt taataaatgt aaagactgtg cactttaatt atacacgggc 22560 tctttctggt tatttattca acaccgccgt cgccatttag aaatcgaaag ggttctgccg 22620 tgcgtcgccg tgcgccacgg gcagagacac gttgcgatac tggaagcggc tcgcccactt 22680 gaactcgggc accaccatgc ggggcagtgg ttcctcgggg aagttctcgc tccacagggt 22740 gcgggtcagc tgcagcgcgc tcaggaggtc gggagccgag atcttgaagt cgcagttggg 22800 gccggaaccc tgcgcgcgcg agttgcggta cacggggttg cagcactgga acaccagcag 22860 ggccggatta ttcacgctgg ccagcaggct ctcgtcgctg atcatgtcgc tgtccagatc 22920 ctccgcgttg ctcagggcga atggggtcat cttgcagacc tgcctgccca ggaaaggcgg 22980 gagcccaggc ttgccgttgc agtcgcagcg caggggcatt agcaggtgcc cacggcccga 23040 ctgcgcctgc gggtacaacg cgcgcatgaa ggcttcgatc tgcctaaaag ccacctgggt 23100 cttggctccc tccgaaaaga acatcccaca ggacttgctg gagaactggt tcgcgggaca 23160 gctggcatcg tgcaggcagc agcgcgcgtc agtgttggca atctgcacca cgttgcgacc 23220 ccaccggttt ttcactatct tggccttgga agcctgctcc tttagcgcgc gctggccgtt 23280 ctcgctggtc acatccatct ctatcacctg ttccttgttg atcatgtttg tcccgtgcag 23340 acactttagg tcgccctccg tctgggtgca gcggtgctcc cacagcgcgc aaccggtggg 23400 ctcccaattc ttgtgggtca cccccgcgta ggcctgcagg taggcctgca ggaagcgccc 23460 catcatggtc ataaaggtct tctggctcgt aaaggtcagc tgcaggccgc gatgctcttc 23520 gttcagccag gtcttgcaga tggcggccag cgcctcggtc tgctcgggca gcatcttaaa 23580 atttgtcttc aggtcgttat ccacgtggta cttgtccatc atggcacgcg ccgcctccat 23640 gcccttctcc caggcggaca ccatgggcag gcttaggggg tttatcactt ccagcggcga 23700 ggacaccgta ctttcgattt cttcttcctc cccctcttcc cggcgcgcgc ccccgctgtt 23760 gcgcgctctt accgcctgca ccaaggggtc gtcttcaggc aagcgccgca ccgagcgctt 23820 gccgcccttg acctgcttga tcagtaccgg cgggttgctg aagcccacca tggtcagcgc 23880 cgcctgctct tcttcgtctt cgctgtctac cactatttct ggggaggggc ttctccgctc 23940 tgcggcaaag gcggcggatc gcttcttttt tttcttggga gccgccgcga tggagtccgc 24000 cacggcgacc gaggtcgagg gcgtggggct gggggtgcgc ggtaccaggg cctcgtcgcc 24060 ctcggactct tcctctgact ccaggcggcg gcggagtcgc ttctttgggg gcgcgcgcgt 24120 cagcggcggc ggagacgggg acggggacgg ggacgggacg ccctccacag ggggtggtct 24180 tcgcgcagac ccgcggccgc gctcgggggt cttctcgcgc tggtcttggt cccgactggc 24240 cattgtatcc tcctcctcct aggcagagag acataaggag tctatcatgc aagtcgagaa 24300 ggaggagagc ttaaccaccc cctcagagac cgccgatgcg cccgccgtcg ccgtcgcccc 24360 cgctaccgcc gacgcgcccg ccacaccgag cgacaccccc acggaccccc ccgccgacgc 24420 acccctgttc gaggaagcgg ccgtggagca ggacccgggc tttgtctcgg cagaggagga 24480 tttgcaagag gaggagaata aggaggagaa gccctcagtg ccaaaagatc ataaagagca 24540 agacgagcac gacgcagacg cacaccaggg tgaagtcggg cggggggacg gagggcatgg 24600 cggcgccgac tacctagacg aaggaaacga cgtgctcttg aagcacctgc atcgtcagtg 24660 cgccatcgtc tgcgacgctc tgcaggagcg cagcgaggtg cccctcagcg tggcggaggt 24720 cagccgcgcc tacgagctca gcctcttttc cccccgggtg cccccccgcc gccgcgaaaa 24780 cggcacatgc gagcccaacc cgcgcctcaa cttctacccc gcctttgtgg tgcccgaggt 24840 cctggccacc tatcacatct tctttcaaaa ttgcaagatc cccatctcgt gccgcgccaa 24900 ccgtagccgc gccgataaga tgctggccct gcgccagggc gaccacatac ctgatatcgc 24960 cgctttggaa gatgtgccaa agatcttcga gggtctgggg cgcaacgaga agcgggcagc 25020 aaactctctg caacaggaaa acagcgaaaa tgagagtcac actggagcgc tggtggagct 25080 ggagggcgac aacgcccgcc tggcggtgct caagcgcagc atcgaggtca cccactttgc 25140 ctaccccgcg ctcaacctgc cccccaaagt catgaacgcg gtcatggacg ggctgatcat 25200 gcgccgcggc cggcccctcg ctccagatgc aaacttgcat gaggagaccg aggacggtca 25260 gcccgtggtc agcgacgagc agctgacgcg ctggctggag agcgcggacc ccgccgaact 25320 ggaggagcgg cgcaagatga tgatggccgc ggtgctggtc accgtagagc tggagtgtct 25380 gcagcgcttc ttcggtgacc ccgagatgca gagaaaggtc gaggagaccc tacactacac 25440 cttccgccag ggctacgtgc gccaggcttg caagatctcc aacgtggagc tcagcaacct 25500 ggtgtcctac ctgggcatct tgcatgaaaa ccgccttggg cagagcgtgc tacactccac 25560 cctgcgcggg gaggcgcgcc gcgactacgt gcgcgactgc gtttacctct tcctctgcta 25620 cacctggcag acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga 25680 gctggagaag cttctgcagc gcgcgctcaa agacctctgg acgggcttca acgagcgctc 25740 ggtggccgcc gcgctagccg acctcatctt ccccgagcgc ctgctcaaaa ccctccagca 25800 ggggctgccc gacttcacca gccaaagcat gttgcaaaat tttaggaact ttatcctgga 25860 gcgttctggc atcctacccg ccacctgctg cgccctgccc agcgactttg tccccctcgt 25920 gtaccgcgag tgccccccgc cgctgtgggg ccactgctac ctgttccaac tggccaacta 25980 cctgtcctac cacgcggacc tcatggagga ctccagcggc gaggggctca tggagtgcca 26040 ctgccgctgc aacctctgca cgccccaccg ctccctggtc tgcaacaccc aactgctcag 26100 cgagagtcag attatcggta ccttcgagct acagggtccg tcctcctcag acgagaagtc 26160 cgcggctccg gggctaaaac tcactccggg gctgtggact tccgcctacc tgcgcaaatt 26220 tgtacctgaa gactaccacg cccacgaaat caggttttac gaggaccaat cccgcccgcc 26280 caaggcggag ctgaccgcct gcgtcatcac ccagggcgag atcctaggcc aattgcaagc 26340 catccaaaaa gcccgccaag agtttttgct gaagaggggt cggggggtgt atctggaccc 26400 ccagtcgggt gaggagctca acccggttcc cccgctgcca ccgccgcggg accttgcttc 26460 ccaggataag catcgccatg gctcccagaa agaagcagca gcggccgccg ctgccgccgc 26520 cccacatgct ggaggaagag gaggaatact gggacagtca ggcagaggag gtttcggacg 26580 aggaggagcc ggagacggag atggaagagt gggaggagga cagcttagac gaggaggctt 26640 ccgaagccga agaggcaggc gcaacaccgt caccctcggc cgcagccccc tcgcaggcgc 26700 ccccgaagtc cgctcccagc atcagcagca acagcagcgc tataacctcc gctcctccac 26760 cgccgcgacc cacggccgac cgcagaccca accgtagatg ggacaccacc ggaaccgggg 26820 ccggtaagtc ctccgggaga ggcaagcaag cgcagcgcca aggctaccgc tcgtggcgcg 26880 ctcacaagaa cgccatagtc gcttgcttgc aagactgcgg ggggaacatc tccttcgccc 26940 gccgcttcct gctcttccac cacggtgtgg ccttcccccg taacgtcctg cattactacc 27000 gtcatctcta cagcccctac tgcggcggca gtgagccaga ggcggccagc ggcggcggcg 27060 cccgtttcgg tgcctaggaa gacccagggc aagacttcag ccaagaaact cgcggcgacc 27120 gcggcgaacg cggtcgcggg ggccctgcgc ctgacggtga acgaacccct gtcgacccgc 27180 gaactgagga accgaatctt ccccactctc tatgccatct tccagcagag cagagggcag 27240 gatcaggaac tgaaagtaaa aaacaggtct ctgcgctccc tcacccgcag ctgtctgtat 27300 cacaagagcg aagaccagct tcggcgcacg ctggaggacg ctgaggcact cttcagcaaa 27360 tactgcgcgc tcactcttaa ggactagctc cgcgcccttc tcgaatttag gcgggaacgc 27420 ctacgtcatc gcagcgccgc cgtcatgagc aaggacattc ccacgccata catgtggagc 27480 tatcagccgc agatgggact cgcggcgggc gcctcccaag actactccac ccgcatgaac 27540 tggctcagtg ccggcccaca catgatctca caggttaatg acatccgcac ccatcgaaac 27600 caaatattgg tgaagcaggc ggcaattacc accacgcccc gcaataatcc caaccccagg 27660 gagtggcccg cgtccctggt gtatcaggaa attcccggcc ccaccaccgt actacttccg 27720 cgtgattccc aggccgaagt ccaaatgact aactcagggg cacagctcgc gggcggctgt 27780 cgtcacaggg tgcggcctcc tcgccagggt ataactcacc tggagatccg aggcagaggt 27840 attcagctca acgacgagtc ggtgagctcc tcgctcggtc tcagacctga cgggaccttc 27900 cagatagccg gagccggccg atcttccttc acgccccgcc aggcgtacct gactctgcag 27960 agctcgtcct cggcgccgcg ctcgggcggc atcgggactc tccagttcgt gcaggagttt 28020 gtgccctcgg tctacttcaa ccccttctcg ggctctcccg gtcgctaccc ggaccagttt 28080 atcccgaact ttgacgccgc gagggactcg gtggacggct acgactgaat gtcgggtgga 28140 cccggtgcag agcaacttcg cctgaagcac cttgaccact gccgccgccc tcagtgcttt 28200 gcccgctgtc agaccggtga gttccagtac ttttccctgc ccgactcgca cccggacggc 28260 ccggcgcacg gggtgcgctt tttcatcccg agtcaggtcc gctctaccct aatcagggag 28320 ttcaccgccc gtcccctact ggcggagttg gaaaaggggc cttctatcct aaccattgcc 28380 tgcatttgct ctaaccctgg attacaccaa gatctttgct gtcatttgtg tgctgagtat 28440 aataaaggct gagatcagaa tctactcggg ctcctgtcgc catcctgtca acgccaccgt 28500 ccaagcccgg cccgatcagc ccgaggtgaa cctcacctgt ggtctgcacc ggcgcctgag 28560 gaaataccta gcttggtact acaacagcac tccctttgtg gtttacaaca gctttgacca 28620 ggacggggtc tcactgaggg ataacctctc gaacctgagc tactccatca ggaagaacaa 28680 caccctcgag ctacttcctc cttacctgcc cgggacttac cagtgtgtca ccggcccctg 28740 cacccacacc cacctgttga tcgtaaacga ctctcttccg agaacagacc tcaataactc 28800 ctctccgcag ttccccagaa caggaggtga gctcaggaaa ccccgggtaa agaagggtgg 28860 acaagagtta acacttgtgg ggtttctggt atatgtgacg ctggtggtgg ctcttttgat 28920 taaggctttt ccttccatgt ctgaactatc cctcttcttt tatgaacaac tcgactagtg 28980 ctaacgggac cctacccaac gaatcgggat tgaatatcgg taaccaggtt gcagtttcac 29040 ttttgattac cttcatagtc ctcttcctgc tagtgctgtc gcttctgtgc ctgcggatcg 29100 ggggctgctg catccacgtt tatatctggt gctggctgtt tagaaggttc ggagaccacc 29160 gcaggtagaa taatgctgct taccctcttt gtcctggcgc tggctgccag ctgccaagcc 29220 ttttccgagg ctgacttcat agagccccag tgcaatatca cttataaatc tgaacgtgcc 29280 atctgtacta ttctaatcaa atgtgttact caacacgata aggtgactgt taaatacaaa 29340 gatcaattaa aaaaagacgc actttacagc agctggcaac caggagatga tcaaaaatac 29400 aatgtaaccg tcttccaggg caaactctcc aaaacttaca attacaattt cccatttgag 29460 cagatgtgtg actttgtcat gtacatggaa aagcagtaca agctgtggcc tccaactccc 29520 cagggctgtg tggaaaatcc aggctctttc tgtatgatct ctctctgtgt aactgtgctg 29580 gcactaatac tcacgcttct gtatctcaga tttaaatcaa ggcaaagctt cattgatgaa 29640 aagaaaatgc cataatcgct caacgcttga ttgctaacac cgggttttta tccgcagaat 29700 gattggaatc accctactaa tcacctccct ccttgcgatt gcccatgggt tggaacgaat 29760 cgaagtccct gtgggggcca atgttaccct ggtggggcct gtcggcaatg ctacattaat 29820 gtgggaaaaa tatactaaaa atcaatgggt ttcttactgc actaacaaaa acagccacaa 29880 gcccagagcc atctgcgatg ggcaaaatct aaccttgatt gatgttcaat tgctggatgc 29940 gggctactat tatgggcagc tgggtacaat gattaattac tggagacccc acagagatta 30000 catgcttcac gtagtaaagg gtcccattag cagcccaacc accacctcta ccacacccac 30060 taccaccact actcccacca ccagcactgc cgcccagcct cctcatagca gaacaaccac 30120 ttttatcaat tccaagtccc actcccccca cattgccggc gggccctccg cctcagactc 30180 cgagaccacc gagatctgct tctgcaaatg ctctgacgcc attgcccagg atttggaaga 30240 tcacgaggaa gatgagcatg actacgcaga tgcatgccag gcatcagagg cagaagcgct 30300 accggtggcc ctaaaacagt atgcagactc ccacaccacc cccaaccttc ctccaccttc 30360 ccagaagcca agtttcctgg gggaaaatga aactctgcct ctttccatac tagctctgac 30420 atctgttgct attttggccg ctctgctggt gcttctatgc tctatatgct acctgatctg 30480 ctgcagaaag aaaaaatctc acggccatgc tcaccagccc ctcatgcact tcccttaccc 30540 tccagagctg ggcgaccaca aactttaagt ctgcagtagc tatctgccca tcccttgtca 30600 gtcgacagcg atgagcccca ctaatctaac agcctctgga cttacaacat tgtctcttaa 30660 tgagaccacc gctcctcaag acctgtacga tggtgtctcc gcgctggtta accagtggga 30720 tcacctgggc atatggtggc tcctcatagg agcagtgacc ctgtgcctaa tcctggtctg 30780 gatcatctgc tgcatcaaaa gcagaagacc caggcggcgg cccatctaca ggcccttcgt 30840 catcacacct gaagataatg atgatgatga caccacctcc aggctgcaga gcctaaagca 30900 gctactcttc tcttttacag catggtaaat tgaatcatgc cccgcatttt catctacttg 30960 cttctccttc cactttttct gggctcctct acattggcca ctgtgtccca catcgaggta 31020 gactgcctca cgcccttcac agtctacctg cttttcggct ttgtcatctg cacctttgtc 31080 tgcagcgtta tcactgtagt gatctgcttc atacagtgca tcgactacat ctgtgtgcgg 31140 gtggcctact ttagacacca cccccagtat cgcaacaggg acatagcggc tctcctaaga 31200 cttgtttaaa tcatggccaa attacctgtg attggtcttc tgattatctg ctgcgtccta 31260 gccgcgattg ggactcaacc taataccacc accagcgctc ccagaaagag acatgtatcc 31320 tgcagcttca agcgtccctg gaatataccc caatgcttta ctgatgaacc tgaaatctct 31380 ttggcttggt acttcagcgt caccgccctt ctcatcttct gcagtacggt tattgctctt 31440 gccatctacc cttcccttaa cctgggctgg aatgctgtca actctatgga atatcccacc 31500 ttcccagaac cagacctgcc agacctggtt gttctaaacg cgtttcctcc tcctccagtt 31560 caaaatcagt ttcgccctcc gtcccctacg cccactgagg tcagctactt taatctaaca 31620 ggcggagatg actgaaaacc tagacctaga aatggacggt ctctgcagcg agcaacgcac 31680 actagagagg cgccggcaaa aagcagagct cgagcgtctt aaacaagagc tccaagacgc 31740 cgtggccata caccagtgca aaaaagggct cttctgtctg gtaaaacagg ccacgctcac 31800 ctatgaaaaa acaggtgaca cccaccgcct aggatacaag ctgcccacac agcgccaaaa 31860 gtttgccctt atgataggtg aacaacccat caccgtcacc cagcactccg tggagacaga 31920 aggctgcatt catgctccct gcaggggcgc tgactgcctc tacaccttga tcaaaaccct 31980 ctgcggtctc agagacctta tccctttcaa ttgatcataa ctgtaatcaa taaaaaatca 32040 cttacttgaa atctgatagc aagactctgt ccaatttttt cagcaacact tccttcccct 32100 cctcccaact ctggtactct aggcgcctcc tagctgcaaa cttcctccac agtctgaagg 32160 gaatgtcaga ttcctcctcc tgtccctccg cacccacgat cttcatgttg ttacagatga 32220 aacgcgcgag atcgtctgac gagaccttca accccgtgta cccctacgat accgagatcg 32280 ctccgacttc tgtccctttc cttacccctc cctttgtatc atccgcagga atgcaagaaa 32340 atccagctgg ggtgctgtcc ctgcacctgt cagagcccct taccacccac aatggggccc 32400 tgactctaaa aatggggggc ggcctgaccc tggacaagga agggaatctc acttcccaaa 32460 acatcaccag tgtcgatccc cctctcaaaa aaagcaagaa caacatcagc cttcagaccg 32520 ccgcacccct cgccgtcagc tccggggccc taaccctttt tgccactccc cccctagcgg 32580 tcagtggcga caaccttact gtgcagtctc aggcccctct tactttggaa gactcaaaac 32640 taactctggc caccaaagga cccctaactg tgtccgaagg caaacttgtc ctagaaacag 32700 agcctcccct gcatgcaagt gacagcagta gcctgggcct tagcgtcacg gccccactta 32760 gcattaacaa tgacagccta ggactagaca tgcaagcgcc catcagctct cgagatggaa 32820 aactggctct aacagtggcg gcccccctaa ctgtggccga gggtatcaat gctttggcag 32880 tagccacagg taatggtatt ggactaaatg aaaccaacac acacctgcag gcaaaactgg 32940 tcgcgcccct aggctttgat accaacggca acattaagct aagcgtcgca ggaggcatga 33000 ggctaaacaa taacacactg atactagatg taaactaccc atttgaggct caaggccaac 33060 tgagcctaag agtgggctcg ggcccactat atgtagattc tagtagtcat aacctaacca 33120 ttagatgcct taggggattg tatgtaacat cttctaacaa ccaaaacggt ctagaggcca 33180 acattaaact aacaaaaggc cttgtgtatg acggaaatgc catagcagtt aatgttggca 33240 aagggctgga atacagccct actggcacaa cagaaaaacc tatacagact aaaataggtc 33300 taggcatgga gtatgacact gagggagcca tgatgacaaa actaggctct ggactaagct 33360 ttgacaattc aggagccatt gtggtgggaa acaaaaatga tgacaggctt actttgtgga 33420 ccacaccgga cccatcgccc aactgtcaga tttactctga aaaagatgct aaactaacct 33480 tggtactgac taaatgtggc agtcaggttg taggcacagt atctattgcc gctcttaaag 33540 gtagccttgt gccaatcact agtgcaatca gtgtggttca gatataccta aggtttgatg 33600 aaaatggggt gctgatgagt aactcttcac ttaatggcga atactggaat tttagaaacg 33660 gagactcaac taatggcaca ccatatacaa acgcagtggg ttttatgcct aatctactgg 33720 cctatcctaa aggtcaaact acaactgcaa aaagtaacat tgtcagccag gtctacatga 33780 acggggacga tactaaaccc atgacattta caatcaactt caatggcctt agtgaaacag 33840 gggatacccc tgtcagtaaa tattccatga cattctcatg gaggtggcca aatggaagct 33900 acatagggca caattttgta acaaactcct ttactttctc ctacatcgcc caagaataaa 33960 gaaagcacag agatgcttgt ttttgatttc aaaattgtgt gcttttattt attttcaagc 34020 ttacagtatt tccagtagtc attagaatag agcttaatta aactgcatga gaacccttcc 34080 acatagctta aattatcacc agtgcaaatg gaaaaaaatc aacatacctt tttatccaga 34140 tatcaaagaa ctctagtggt cagttttccc ccaccctccc agctcacaga atacacagtc 34200 ctttcccccc ggctggcttt aaacaacact atctcattgg taacagacat atttttaggt 34260 gtaataatcc acacggtctc ttggcgggcc aaacgctggt ctgtgatgtt aataaactcc 34320 ccaggcagct ctttcaagtt cacgtcgctg tccaactgct gaagcgctcg cggctccgac 34380 tgcgcctcta gcggaggcaa cggcagcacc cgatccttga tctataaagg agtagagtca 34440 taatccccca taagaatagg gcggtgatgc agcaacaagg cgcgcagcaa ctcctgccgc 34500 cgcctctccg tacgacagga atgcaacggg gtggtggtct cctccgcgat aatccgcacc 34560 gctcgcagca tcagcatcct cgtcctccgg gcacagcagc gcatcctgat ctcactgaga 34620 tcggcgcagt aagtgcagca caacaccaag atgttattta agatcccaca gtgcaaagca 34680 ctgtacccaa agctcatggc gggaaggaca gcccccacgt gaccatcgta ccagatcctc 34740 aggtaaatca aatgacgacc tctcataaac acgctggaca tatacatcac ctccttgggc 34800 atgagctgat tcaccacctc tcgataccac aggcatcgct gattaattaa agacccctcg 34860 agcaccatcc tgaaccagga agccagcacc tgaccccccg ccaggcactg cagggacccc 34920 ggtgaatcgc agtggcagtg aagactccag cgctcgtagc cgtgaaccat agagctggtc 34980 attatatcca cattggcaca acacagacac actttcatac actttttcat gattagcagc 35040 tcctctctag tcaagaccat atcccaagga atcacccact cttgaatcaa ggtaaatccc 35100 acacagcagg gcaggcctct cacataactc acgttatgca tagtgagcgt gtcgcaatct 35160 ggaaataccg gatgatcttc catcaccgaa gcccgggtct ccgtctcaaa gggaggtaaa 35220 cggtccctcg tgtagggaca gtggcgggat aatcgagatc gtgttgaacg tagagtcatg 35280 ccaaagggaa cagcggacgt actcatattt cctccagcag aaccaagtgc gcgcgtggca 35340 gctatccctg cgtcttctgt ctcgccgcct gccccgctcg gtgtagtagt tgtaatacag 35400 ccactccctc agaccgtcaa ggcgctccct ggcgtccgga tctataacaa caccgtcctg 35460 cagcgccgcc ctgatgacat ccaccaccgt agagtatgcc aagcccagcc acgaaatgca 35520 ctcactttga cagcgagaga taggaggagc gggaagagat ggaagaacca tgatagtaaa 35580 agaactttta ttccaatcga tcctctacaa tgtcaaagtg tagatctatc agatggcact 35640 ggtctcctcc gctgagtcga tcaaaaataa cagctaaacc acaaacaaca cgattggtca 35700 aatgctgcac aagggcttgc agcataaaat cgcctcgaaa gtccaccgca agcataacat 35760 caaagccacc gcccctatca tgatctatga taaaaacccc acagctatcc accagaccca 35820 tatagttttc atctctccat cgtgaaaaaa tatttacaag ctcctccttt aaatcacctc 35880 caaccaattc aaaaagttga gccagaccgc cctccacctt cattttcagc atgcgcatca 35940 tgattgcaaa aattcaggct cctcagacac ctgtataaga ttgagaagcg gaacgttaac 36000 atcaatgttt cgctcgcgaa gatcgcgcct cagtgcaagc atgatataat cccacaggtc 36060 ggagcggatc agcgaggaca tctccccgcc aggaaccaac tcaacggagc ctatgctgat 36120 tataatacgc atattcgggg ctatgctaac cagcacggcc cccaaatagg cgtactgcat 36180 aggcggcgac aaaaagtgaa cagtttgggt taaaaaatca ggcaaacact cgcgcaaaaa 36240 agcaagaaca tcataaccat gctcatgcaa atagatgcaa gtaagctcag gaacgaccac 36300 agaaaaatgc acaatttttc tctcaaacat gactgcgagc cctgcaaaaa ataaaaaaga 36360 aacattacac aagagtagcc tgtcttacaa tgggatagac tactctaacc aacataagac 36420 gggccacgac atcgcccgcg tggccataaa aaaaattatc cgtgtgatta aaaagaagca 36480 cagatagctg gccagtcata tccggagtca tcacgtgcga acccgtgtag acccccgggt 36540 tggacacatc ggccaaacaa agaaagcggc caatgtatcc cggaggaatg ataacactaa 36600 gacgaagata caacagaata accccatggg ggggaataac aaagttagta ggtgaataaa 36660 aacgataaac acccgaaact ccctcctgcg taggcaaaat agcgccctcc ccttccaaaa 36720 caacatacag cgcttccaca gcagccatga caaaagactc aaaacactca aaagactcag 36780 tcttaccagg aaaataaaag cactctcaca gcaccagcac taatcagagt gtgaagaggg 36840 ccaagtgccg aacgagtata tataggaatt aaaaatgacg taaatgtgta aaggtcaaaa 36900 aacgcccaga aaaatacaca gaccaacgcc cgaaacgaaa acccgcgaaa aaatacccag 36960 aagttcctca acaaccgcca cttccgcttt cccacgatac gtcacttcct caaaaatagc 37020 aaactacatt tcccacatgt acaaaaccaa aacccctccc cttgtcaccg cccacaactt 37080 acataatcac aaacgtcaaa gcctacgtca cccgccccgc ctcgccccgc ccacctcatt 37140 atcatattgg cctcaatcca aaataaggta tattattgat gatg 37184 <210> 6 <211> 37172 <212> DNA <213> Great Ape Adenovirus <400> 6 catcatcaat aatatacctt attttggatt gtggccaata tgataatgag gtgggcgggg 60 cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgc ggaagtgtgg catttgcaag 120 tgggaggagc tcacatgtaa gcttccgtcg cggaaaatgt gacgttttta atgagcgccg 180 cctacctccg gaagtgccaa ttttcgcgcg cttttcaccg gatatcgtag taattttggg 240 cgggaccatg taagatttgg ccattttcgc gcgaaaagtg aaacggggaa gtgaaaactg 300 aataataggg cgttagtcat agcgcgtaat atttaccgag ggccgaggga ctttgaccga 360 ttacgtggag gactcgccca ggtgtttttt acgtgaattt ccgcgttccg ggtcaaagtc 420 tccgttttta ttgtcaccgt catctgacgc ggagggtatt taaacccgct gcgctcctaa 480 agaggccact cttgagtgcc agcgagaaga gttttctcct ccgctccgtt tcggcgatcg 540 aaaaatgaga cacttagcct gcactccggg tcttttgtcc ggccgggcgg cgtccgagct 600 tttggacgct ttgctcaatg aggttctgag cgatgatttt ccgtctacta cccactttag 660 cccacctact cttcacgaac tgtacgatct ggatgtactg gtggatgtga acgatcccaa 720 cgaggaggcg gtttctacgt tttttcccga gtctgcgctt ttggccgccc aggagggatt 780 tgacctacac actccgccgc tgcctatttt agagtctccg ctgccggagc ccagtggtat 840 accttatatg cctgaactgc ttcccgaagt ggtagacctg acctgccacg agccgggctt 900 tccgcccagc gacgatgagg gtgagccttt tgctttagac tatgctgaga tacctgggct 960 cggttgcagg tcttgtgcat atcatcagag ggttaccgga gaccccgagg ttaagtgttc 1020 gctgtgctat atgaggctga cctcttcctt tatctacagt aagttttttg tgtaggtggg 1080 ctttttgggt aggtgggttt tgtggcagga caggtgtaaa tgttgcttgt gttttttgta 1140 cctgcaggtc cggtgtccga gccagacccg gagcccgacc gcgatcccga gccggatccc 1200 gagcctcctc gcagggcaag gaaattacct tccattttgt gcaagcctaa gacacctgtg 1260 aggaccagcg aggcggacag cactgactct ggcacttcta cctctcctcc tgaaattcac 1320 ccagtggttc ctttgggtat acataaacct gttgctatta gagtttgcgg gcgacgccct 1380 gcagtagagt gcattgagga cttgcttaac gatcccgagg gacctttgga cttgagcatt 1440 aaacgcccta ggcaataaac cccacctaag taataaaccc cacctaagta ataaacttta 1500 ccgcccttgg ttattgagat gacgcccaat gtttgctttt gaatgacttc atgtgtataa 1560 taaaagtgag tgtggtcata ggtctcttgt ttgtctgggc ggggcttaag ggtatataag 1620 tttctcgggg ctaaacttgg ttacacttga ccccaatgga ggcgtggggg tgcttggagg 1680 agtttgcgga cgtgcgccgt ttgctggacg agagctctag caatacctat agtatttgga 1740 ggtatctgtg gggctctact caggccaagt tggtctccag aattaagcag gattacaagt 1800 gcgattttga agagcttttt agttcctgtg gtgagctttt gcaatccttg aatctgggcc 1860 accaggctat cttccaggaa aaggttctct cgactttgga tttttccact cccgggcgca 1920 ccgccgcttg tgtggctttt gtgtcttttg tgcaagataa atggagcggg gagacccacc 1980 tgagtcacgg ctacgtgctg gatttcatgg cgatggctct ttggagggct tacaacaaat 2040 ggaagattca gaaggaactg tacggttccg ccctacgtcg tccacttctg cagcggcagg 2100 ggctgatgtt tcccgaccat cgccagcatc agaatctgga agacgagtcg gaggagcgag 2160 cggagaagat cagcttgaga gccggcctgg accctcctca ggaggaatga atctcccgca 2220 ggtggttgac ctgtttcccg aactgagacg ggtcctgact atcagggaag atggtcagtt 2280 tgtgaagaag ctgaagaggg atcggggtga gggagatgat gaggcggcta gcaatttagc 2340 ttttagtctg ataacccgcc accgaccgga atgtattacc tatcagcaga ttaaggagag 2400 ttgtgccaac gagctggatc ttttgggtca gaagtatagc atagaacagc ttaccactta 2460 ctggcttcag cccggggatg attgggaaga ggcgatcagg gtgtatgcaa aggtggccct 2520 gcggcccgat tgcaagtata agattactaa gttggttaat attagaaact gctgctatat 2580 ttctgggaac ggggccgaag tggagataga tactgaggac agggtggcta ttaggtgttg 2640 catgataaac atgtggcccg ggatactggg gatggatggg gtgatattta tgaatgtaag 2700 gttcacgggc cccaacttta atggtacggt gttcatgggc aacaccaact tgctcctgca 2760 tggtgcgagt ttctatgggt ttaacaacac ctgtatagag gcctggaccg atgtaaaggt 2820 tcgaggttgt tccttttata gctgttggaa ggcggtggtg tgtcgcccta aaagcagggg 2880 ttctgtgaag aaatgcttgt ttgaaaggtg caccctaggt atcctttctg agggcaactc 2940 cagggtgcgc cataatgtgg cttcgaactg cggttgcttc atgcaagtga agggggtgag 3000 cgttatcaag cataactcgg tctgtggaaa ctgcgaggat cgcgcctctc agatgctgac 3060 ctgctttgat ggcaactgtc acctgttgaa gaccattcat ataagcagtc accccagaaa 3120 ggcctggccc gtgtttgagc ataacattct gacccgctgt tccttgcatc tgggggtcag 3180 gaggggtatg ttcctgcctt accagtgtaa cttcagccac actaaaatcc tgctggaacc 3240 cgagtgcatg actaaggtca gcctgaatgg tgtgtttgat gtgagtctga agatttggaa 3300 ggtgctgagg tatgatgaga ccaggaccag gtgccgaccc tgcgagtgcg gcggcaagca 3360 catgagaaat cagcctgtga tgttggatgt gaccgaggag cttaggcctg accatctggt 3420 gctggcctgc accagggccg agtttgggtc tagcgatgag gataccgatt gaggtgggta 3480 aggtgggcgt ggctagcagg gtgggcgtgt ataaattggg ggtctaaggg gtctctctgt 3540 ttgtcttgca acagccgccg ccatgagcga caccggcaac agctttgatg gaagcatctt 3600 tagcccctat ctgacagtgc gcatgcctca ctgggccgga gtgcgtcaga atgtgatggg 3660 ttccaacgtg gatggacgtc ccgttctgcc ttcaaattcg tctacgatgg cctacgcgac 3720 cgtgggagga actccgttgg acgccgcgac ctccgccgcc gcctccgccg ccgccgcgac 3780 cgcgcgcagc atggctacgg acctttacag ctctttggtg gcgagcagcg cggcctctcg 3840 cgcgtctgct cgggatgaga aactgactgc tctgctgctt aaactggaag acttgacccg 3900 ggagctgggt caactgaccc agcaggtctc cagcttgcgt gagagcagcc ttgcctcccc 3960 ctaatggccc ataatataaa taaaagccag tctgtttgga ttaagcaagt gtatgttctt 4020 tatttaactc tccgcgcgcg gtaagcccgg gaccagcggt ctcggtcgtt tagggtgcgg 4080 tggattcttt ccaacacgtg gtacaggtgg ctctggatgt ttagatacat gggcatgagt 4140 ccatccctgg ggtggaggta gcaccactgc agagcttcgt gctcgggggt ggtgttgtat 4200 atgatccagt cgtagcagga gcgctgggcg tggtgctgaa aaatgtcctt aagcaagagg 4260 cttatagcta gggggaggcc cttggtgtaa gtgtttacaa atctgctcag ctgggagggg 4320 tgcatccggg gggatatgat gtgcatcttg gactggattt ttaggttggc tatgttccca 4380 cccagatccc ttctgggatt catgttgtgc aggaccacca gcacggtata tccagtgcac 4440 ttgggaaatt tatcgtggag cttagacggg aatgcatgga agaacttgga gacgcccttg 4500 tggcctccca gattttccat acattcgtcc atgatgatgg caatgggccc gtgggaagct 4560 gcctgagcaa aaacgtttct gggatcgctc acatcgtagt tatgttccag ggtgaggtca 4620 tcataggaca tctttacgaa tcgggggcgg agggtcccgg actgggggat gatggtaccc 4680 tcgggccccg gggcgtagtt cccctcacag atctgcatct cccaggcttt catttcagag 4740 ggagggatca tatccacctg cggggcgatg aaaaagacag tttctggcgc aggggagatt 4800 aactgggatg agagcaggtt tctgagcagc tgtgactttc cacagccggt gggcccatat 4860 atcacgccta tcaccggctg cagctggtag ttaagagagc tgcagctgcc gtcctcccgg 4920 agcagggggg ccacctcgtt gagcatatcc ctgacgtgga tgttttccct gaccagttcc 4980 gccagaaggc gctcgccgcc cagcgaaagc agctcttgca aggaagcaaa atttttcagc 5040 ggtttcaggc catcggccgt gggcatgttt ttcagcgtct gggtcagcag ctccagcctg 5100 tcccagagct cggtgatgtg ctctacggca tctcgatcca gcagatctcc tcgtttcgcg 5160 ggttggggcg gctttcgctg tagggcacca gccgatgggc gtccagcggg gccagagtca 5220 tgtccttcca tgggcgcaga gtcctcgtca gggtggtctg ggtcacggtg aaggggtgcg 5280 ctccgggttg ggcgctggcc agggtgcgct tgaggctggt tctgctggtg ctgaatcgct 5340 gccgctcttc gccctgcgcg tcggccaggt agcatttgac catggtctcg tagtcgagac 5400 cctcggcggc gtgccccttg gcgcggagct ttcccttgga ggtggcgccg cacgaggggc 5460 actgcaggct cttcagggcg tagagcttgg gagcgagaaa cacggactct ggggagtagg 5520 cgtccgcgcc gcaggccgag cagaccgtct cgcattccac cagccaagtg agttccgggc 5580 ggtcagggtc aaaaaccagg ctgcccccat gctttttgat gcgtttctta cctcggctct 5640 ccatgaggcg gtgtcccttc tcggtgacga agaggctgtc cgtgtccccg tagaccgatt 5700 tcaggggcct gtcttccagc ggagtgcctc tgtcctcctc gtagagaaac tctgaccact 5760 ctgagacaaa ggcccgtgtc caggccagga cgaaggaggc cacgtgggag gggtagcggt 5820 cgttgtccac tagcgggtcc accttctcca gggtgtgcag gcacatgtcc ccctcctccg 5880 cgtccagaaa agtgattggc ttgtaggtgt aggacacgtg accgggggtt cccgacgggg 5940 gggtataaaa gggggtgggt gccctttcat cttcactctc ttccgcatcg ctgtctgcga 6000 gagccagctg ctggggtaag tattcccttt cgaaggcggg catgacctca gcgctcaggt 6060 tgtcagtttc taaaaatgag gaagatttga tgttcacctg tccggaggtg atacctttga 6120 gggtacctgg gtctatctgg tcagaaaaca ctattttttt gttatcaagc ttggtggcga 6180 acgacccgta gagggcgttg gagagcagct tggcgatgga gcgcagggtc tggtttttgt 6240 cgcggtcggc tcgctccttg gccgcgatgt tgagttgcac gtactcgcgg gccacgcact 6300 tccactcggg gaagacggtg gtgcgctcgt ctgggatcag gcgcaccctc cagccgcggt 6360 tgtgcagggt gaccatgtcg acgctggtgg cgacctcacc gcgcaggcgc tcgttggtcc 6420 agcagaggcg gccgcccttg cgcgagcaga aggggggtag ggggtccagc tggtcctcgt 6480 tcggggggtc cgcgtcgatg gtaaagaccc cggggagcag acgcgggtca aagtagtcga 6540 tcttgcaagc ttgcatgtcc agagcccgct gccattcgcg ggcggcgagc gcgcgctcgt 6600 aggggttgag gggcgggccc cagggcatgg ggtgggtgag cgcagaggcg tacatgccgc 6660 agatgtcata cacgtacagg ggttccctga ggatgccgag gtaggtgggg tagcagcgcc 6720 ccccgcggat gctggcgcgc acgtagtcat agagttcgtg ggagggggcc agcatgttgg 6780 gcccgaggtt ggtgcgctgg gggcgctcgg cgcggaagac gatctgcctg aagatggcgt 6840 gggagttgga ggagatggtg ggccgctgga agacgttgaa gcttgcttct tgcaagccca 6900 cggagtccct gacgaaggag gcgtaggact cgcgcagctt gtgcaccagc tcggcggtga 6960 cctggacgtc gagcgcacag tagtcgaggg tctcacggat gatgtcatac ttatcctccc 7020 ccttcttttt ccacagctcg cggttgagga cgaactcttc gcggtctttc cagtactctt 7080 ggaggggaaa cccgtccgtg tccgaacggt aagagcctag catgtagaac tggttgacgg 7140 cctggtaggg gcagcagccc ttctccacgg gcagcgcgta ggcctgcgcc gccttgcgga 7200 gggaggtgtg ggtgagggcg aaagtgtccc tgaccatgac tttgaggtat tgatgtctga 7260 agtctgtgtc atcgcagccg ccctgttccc acagggtgta gtccgtgcgc tttttggagc 7320 gcgggttggg cagggagaag gtgaggtcat tgaagaggat cttccccgct cgaggcatga 7380 agtttctggt gatgcgaaag ggccctggga ccgaggagcg gttgttgatg acctgggcgg 7440 ccaggacgat ctcgtcaaag ccgtttatgt tgtggcccac gatgtagagc tccaggaagc 7500 ggggctggcc cttgatggag gggagctttt taagttcctc gtaggtgagc tcctcgggcg 7560 attccaggcc gtgctcctcc agggcccagt cttgcaagtg agggttggcc gccaggaagg 7620 atcgccagag gtcgcgggcc atgagggtct gcaggcggtc gcggaaggtt ctgaactgtc 7680 gccccacggc catcttttcg ggggtgatgc aatagaaggt gagggggtct ttctcccagg 7740 ggtcccatct gagctctcgg gcgaggtcgc gtgcggcggc gaccagagcc tcgtcgcccc 7800 ccagtttcat gaccagcatg aagggcacga gctgcttgcc aaaggctccc atccaagtgt 7860 aggtctctac atcgtaggtg acaaagaggc gctccgtgcg aggatgagag ccgatcggga 7920 agaactggat ctcccgccac cagttggagg attggctgtt gatgtggtga aagtagaagt 7980 cccgtctgcg ggccgagcac tcgtgctggc ttttgtaaaa gcgaccgcag tactggcagc 8040 gctgcacggg ttgtatatct tgcacgaggt gaacctggcg acctctgacg aggaagcgca 8100 gcgggaatct aagtcccccg cctggggtcc cgtgtggctg gtggtcttct actttggttg 8160 tctggccgcc agcatctgtc tcctggaggg cgatggtgga acagaccacc acgccgcgag 8220 agccgcaggt ccagatctcg gcgctcggcg ggcggagttt gatgacgaca tcgcgcacat 8280 tggagctgtc catggtctcc agctcccgcg gcggcaggtc agccgggagt tcctggaggt 8340 ttacctcgca gagacgggtc aacgcacggg cagtgttaag atggtatctg atttcaaggg 8400 gcgtgttggc ggcggagtcg atggcttgca ggaggccgca gccccggggg gccacgatgg 8460 ttccccgtgg ggcgcgaggg gaggcggaag ctgggggtgt gttcagaagc ggtgacgcgg 8520 gcgggccccc ggaggtaggg ggggttccgg ccccacaggc atgggcggca ggggcacgtc 8580 ttcgccgcgc gcgggcaggg gctggtgctg gctccgaaga gcgcttgcgt gcgcgacgac 8640 gcgacggttg gtgtcctgta tctggcgcct ctgagtgaag accacgggtc ccgtgacctt 8700 gaacctgaaa gagagttcga cagaatcaat ctcggcatcg ttgacagcgg cctggcgcag 8760 gatctcctgc acgtcgcccg agttgtcctg gtaggcgatc tctgccatga actgctcgat 8820 ctcttcctcc tggagatctc ctcgtccggc gcgctccacg gtggccgcca ggtcgttgga 8880 gatgcgaccc atgagctgcg agaaggcgtt gagtccgccc tcgttccaga cccggctgta 8940 gaccacgccc ccctcggcgt cgcgggcgcg catgaccacc tgggccaggt tgagctccac 9000 gtgtcgcgtg aagacggcgt agttgcgcag gcgctggaaa aggtagttca gggtggtggc 9060 ggtgtgctcg gcgacaaaga agtacatgac ccagcgccgc aacgtggatt cattgatgtc 9120 ccccaaggcc tccaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 9180 ggagttgcga gcggacacgg tcaactcctc ctccagaaga cggatgagct cggcgacagt 9240 gtcgcgcacc tcgcgctcga aggccacggg gggcgcttct tcctcttcca cctcttcttc 9300 catgattgct tcttcttctt cctcagccgg gacgggaggg ggcggcggcg ggggaggggc 9360 gcggcggcgg cggcggcgca ccgggaggcg gtcgatgaag cgctcgatca tctccccccg 9420 catgcggcgc atggtctcgg tgacggcgcg gccgttctcc cgggggcgca gctcgaagac 9480 gccgcctttc atctcgccgc ggggcgggcg gccgtgaggt agcgagacgg cgctgactat 9540 gcatcttaac aattgctgtg taggtacgcc gccaagggac ctgattgagt ccagatccac 9600 cggatccgaa aacctttgga ggaaagcgtc tatccagtcg cagtcgcaag gtaggctgag 9660 caccgtggcg ggcgggggcg ggtcgggaga gttcctggcg gagatgctgc tgatgatgta 9720 attaaagtag gcggtcttga gaaggcggat ggtggacagg agcaccatgt ctttgggtcc 9780 ggcctgttgg atgcggaggc ggtcggccat gccccaggcc tcgttctgac accggcgcag 9840 gtctttgtag tagtcttgca tgagtctttc caccggcacc tcttctcctt cctcttctcc 9900 atctcgccgg tggtttctcg cgccgcccat gcgcgtgacc ccaaagcccc tgagcggctg 9960 cagcagggcc aggtcggcga ccacgcgctc ggccaagatg gcctgctgta cctgagtgag 10020 ggtcctctcg aagtcatcca tgtccacgaa gcggtggtag gcgcccgtgt tgatggtgta 10080 ggtgcagttg gccatgacgg accagttgac ggtctggtgt cccggctgcg agagctccgt 10140 gtaccgcagg cgcgagaagg cgcgggaatc gaacacgtag tcgttgcaag tccgcaccag 10200 atactggtag cccaccagga agtgcggcgg aggttggcga tagaggggcc agcgctgggt 10260 ggcgggggcg ccgggcgcca ggtcttccag catgaggcgg tggtatccgt agatgtacct 10320 ggacatccag gtgatgccgg cggcggtggt ggtggcgcgc gcgtagtcgc ggacccggtt 10380 ccagatgttt cgcaggggcg agaagtgttc catggtcggc acgctctggc cggtgaggcg 10440 cgcgcagtcg ttgacgctct atacacacac aaaaacgaaa gcgtttacag ggctttcgtt 10500 ctgtagcctg gaggaaagta aatgggttgg gttgcggtgt gccccggttc gagaccaagc 10560 tgagctcggc cggctgaagc cgcagctaac gtggtattgg cagtcccgtc tcgacccagg 10620 ccctgtatcc tccaggatac ggtcgagagc ccttttgctt tcttggccaa gcgcccgtgg 10680 cgcgatctgg gatagatggt cgcgatgaga ggacaaaagc ggctcgcttc cgtagtctgg 10740 agaaacaatc gccagggttg cgttgcggcg taccccggtt cgagccccta tggcggcttg 10800 gatcggccgg aaccgcggct aacgtgggct gtggcagccc cgtcctcagg accccgccag 10860 ccgacttctc cagttacggg agcgagcccc ttttgttttt tattttttag atgcatcccg 10920 tgctgcggca gatgcgcccc tcgccccggc ccgatcagca gcagcaacag caggcatgca 10980 gacccccctc tcctctcccc gccccggtca ccacggccgc ggcggccgtg tccggcgcgg 11040 ggggtgcgct ggagtcagat gagccaccgc ggcggcgacc taggcagtat ctggacttgg 11100 aagagggcga gggactggcg cggctggggg cgagctcccc agagcgtcac ccgcgggtgc 11160 agttgaaaag ggacgcgcgc gaggcgtacc tgccgcggca aaacctgttt cgcgaccgcg 11220 ggggcgagga gcccgaggag atgcgagact gcaggttcca agcagggcgc gagctgcgcc 11280 gcggcttgga cagagagcgc ttgctgcgcg aggaggactt tgagcccgac acgcagacgg 11340 gcatcagccc cgcgcgcgcg cacgtggccg cggccgacct ggtgaccgcc tacgagcaga 11400 cggtgaacca ggagcgcaac ttccaaaaaa gcttcaacaa ccacgtgcgc acgctggtgg 11460 cgcgcgagga ggtgaccctg ggtctcatgc atctgtggga cctggtggag gcgatcgtgc 11520 agaaccccag cagcaagccc ctgaccgcgc agctgttcct ggtggtgcag cacagcaggg 11580 acaacgatgc cttcagggag gcgctgctga acatcaccga gccggagggg cgctggctcc 11640 tggacctgat aaacatcctg cagagcatag tggtgcagga gcgcagcctg agcctggccg 11700 agaaggtggc ggccattaac tattctatgc tgagcctggg caagttctac gcccgcaaga 11760 tctacaagac cccctacgtg cccatagaca aggaggtgaa gatagacagc ttctacatgc 11820 gcatggcgct aaaggtgctg accctgagcg acgacctggg agtgtaccgc aacgagcgca 11880 tccacaaggc cgtgagcgcc agccggcggc gcgagctgag cgaccgcgag ctgatgcaca 11940 gtctgcaacg cgcgctgacc ggcgcgggcg agggcgacag ggaggtcgag tcctacttcg 12000 acatgggggc cgacctgcac tggcagccga gccgccgcgc cctggaggcg gcgggggcgt 12060 atggcggccc cctggcggcc gatggcgagg aagaggagga ctatgagcta gaggagggcg 12120 agtacctgga ggactgacct ggctggtggt gttttggtat agatgcaaga tccgaacgtg 12180 gcggacccgg cggtccgggc ggcgctgcag agccagccgt ccggcattaa ctcctctgac 12240 gactgggccg cggccatggg tcgcatcatg gccctgaccg cgcgcaaccc cgaggccttc 12300 aggcagcagc ctcaggctaa ccggctggcg gccatcttgg aagcggtagt gcccgcgcgc 12360 tccaacccca cccacgagaa ggtgctggcc atagtcaacg cgctggcgga gagcagggcc 12420 atccgggcgg acgaggccgg actggtgtac gatgcgctgc tgcagcgggt ggcgcggtac 12480 aacagcggca acgtgcaaac caacctggac cgcctggtga cggacgtgcg cgaggccgtg 12540 gcgcagcgcg agcgcttgca tcaggacggt aacctgggct cgctggtggc gctaaacgcc 12600 ttcctcagca cccagccggc caacgtaccg cgggggcagg aggactacac caacttcttg 12660 agcgcgctgc ggctgatggt gaccgaggtc cctcagagcg aagtgtacca gtcggggccc 12720 gactacttct tccagaccag cagacagggc ttgcaaaccg tgaacctgag ccaggctttc 12780 aagaacctgc gggggctgtg gggagtgaag gcgcccaccg gcgaccgggc tacggtgtcc 12840 agcctgctaa cccccaactc gcgcctgctg ctgctgctga tcgcgccctt cacggacagc 12900 gggagcgtct cgcgggagac ctatctgggc cacctgctga cgctgtaccg cgaggccatc 12960 gggcaggcgc aggtggacga gcacaccttc caggagatca ccagcgtgag ccacgcgctg 13020 gggcaggagg acacgggcag cctgcaggcg accctgaact acctgctgac caacaggcgg 13080 cagaagattc ccacgctgca cagcctgacc caggaggagg agcgcatctt gcgctacgtg 13140 cagcagagcg tgagcctgaa cctgatgcgc gacggcgtga cgcccagcgt ggcgctggac 13200 atgaccgcgc gcaacatgga accgggcatg tacgcttccc agcggccgtt catcaaccgc 13260 ctgatggact acttgcatcg ggcggcggcc gtgaaccccg agtacttcac caatgccatt 13320 ctgaatcccc actggatgcc ccctccgggt ttctacaacg gggactttga ggtgcccgag 13380 gtcaacgacg ggttcctctg ggatgacatg gatgacagtg tgttctcccc caacccgctg 13440 cgcgccgcgt ctctgcgatt gaaggagggc tctgacaggg aaggaccgag gagtttggcc 13500 tcctccctgg ctctgggggc ggtgggcgcc acgggcgcgg cggcgcgggg cagcagcccc 13560 ttccccagcc tggcggactc tctgaatagc gggcgggtga gcaggccccg cttgctaggc 13620 gaggaggagt atctgaacaa ctccctgcta cagcccgtga gggacaaaaa cgctcagcgg 13680 cagcagtttc ccaacaacgg gatagagagc ctggtggaca agatgtccag atggaagacg 13740 tatgcgcagg agtacaagga gtgggaggac cgacagccgc ggcccctgcc gccccctaga 13800 cagcgctggc agcggcgtgc gtccaaccgc cgctggaggc aggggcccga ggacgatgat 13860 gactctgcag atgacagcag cgtgttggat ctgggcggga gcgggaaccc cttttcgcac 13920 ctgcgcccac gcctgggcaa gatgttttaa aagagaaaaa taaaaactca ccaaggccat 13980 ggcgacgagc gttggttttt ttgttccctt ccttagtatg cggcgcgcgg cgatgttcga 14040 ggaggggcct cccccctctt acgagagcgc gatgggaatt tctcctgcgg cgcccctgca 14100 gcctccctac gtgcctcctc ggtacctgca acctacaggg gggagaaata gcatctgtta 14160 ctctgagctg cagcccctgt acgataccac cagactgtac ctggtggaca acaagtccgc 14220 ggacgtggcc tccctgaact accagaacga ccacagcgat tttttgacca cggtgatcca 14280 aaacaacgac ttcaccccaa ccgaggccag tacccagacc ataaacctgg acaacaggtc 14340 gaactggggc ggcgacctga agactatcct gcacaccaat atgcccaacg tgaacgagtt 14400 catgttcacc aactctttta aggcgcgggt gatggtggcg cgcgagcagg gggaggcgaa 14460 gtacgagtgg gtggacttca cgctgcccga gggcaactat tcagagacca tgactctcga 14520 cctgatgaac aatgcgatcg tggaacacta tctgaaagtg ggcaggcaga acggggtgaa 14580 ggagagcgat atcggggtca agtttgacac cagaaacttt cgtctgggct gggaccccgt 14640 gaccgggctg gtcatgccgg gggtctacac caacgaggcc tttcatcccg atatagtgct 14700 cctgcccggc tgtggggtgg actttaccca gagccggctg agcaacctgc tgggcgttcg 14760 caagcggcaa cctttccagg agggtttcaa gatcacctat gaggatctgg aggggggcaa 14820 cattcccgcg ctccttgatc tggacgccta cgaggagagc ttgaaacccg aggagagcgc 14880 tggcgacagc ggcgagagtg gcgaggagca agccggcggc ggtggcagcg cgtcggtaga 14940 aaacgaaagt actcccgcag tggcggcgga cgctgcggag gtcgagccgg aggccatgca 15000 gcaggacgca gaggagggcg cgcaggagga catgaacaat ggggagatca ggggcgacac 15060 tttcgccacc cggggcgaag aaaaagaggc agaggcggcg gcggcgacgg cggaagccga 15120 aaccgaggca gaggcagagc ccgagaccga agttatggaa gacatgaatg atggagaacg 15180 taggggtgac acgtttgcca cccggggcga agagaaggcg gcggaggcag aagccgcggc 15240 tgaggaggcg gctgcggctg cggccaaggc tgaggctgcg gctgaggcta aggtcgaagc 15300 cgatgttgcg gttgaggctc aggctgagga ggaggcggcg actgaagcag ttaaggaaaa 15360 ggcccaggca gagcaggaag agaaaaaacc tgtcattcaa cctctaaaag aagatagcaa 15420 aaagcgcagt tacaacgtca tcgagggcag cacctttacc caataccgca gctggtacct 15480 ggcttacaac tacggcgacc cggtcaaggg ggtgcgctcg tggaccctgc tctgcacgcc 15540 ggacgtcacc tgcggctccg agcagatgta ctggtcgctg ccaaacatga tgcaagaccc 15600 ggtgaccttc cgttccacgc ggcaggttag caactttccg gtggtgggcg ccgaactgct 15660 gccagtgcac tccaagagtt tttacaacga gcaggccgtc tactcccagc tgatccgcca 15720 ggccacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc 15780 gccggccccc accatcacca ccgtcagtga aaacgttcct gccctcacag atcacgggac 15840 gctaccgctg cgcaacagca tctcaggagt ccagcgagtg accattactg acgccagacg 15900 ccggacctgc ccctacgttt acaaggcctt gggcatagtc tcgccgcgcg tcctctccag 15960 tcgcactttt taaaacacat ctaccctcac gctccaaaat catgtccgta ctcatctcgc 16020 ccagcaacaa caccggctgg gggctgcgcg cgcccagcaa gatgtttgga ggggcgagga 16080 aacgctccga acagcaccca gtgcgcgtgc gcggccacta ccgcgcgccc tggggtgcgc 16140 acaagcgcgg gcgcacaggg cgcaccactg tggatgatgt cattgactcc gtagtggagc 16200 aggcgcgcca ctacacaccc ggcgcgccga ccgcctccgc cgtgtccacc gtggaccagg 16260 cgatcgaaag cgtggtacag ggggcgcggc actatgccaa ccttaaaagt cgccgccgcc 16320 gcgtggcgcg ccgccatcgc cggagacccc gggctactgc cgccgcgcgc cttaccaagg 16380 ctctgctcaa gcgcgccagg cgaactggcc accgggccgc catgagggcc gcacggcggg 16440 ctgccgctgc cgcgagcgcc gtggccccgc gggcacgaag gcgcgcggcc gctgccgccg 16500 ccgccgccat ttccagcttg gcctcgacgc ggcgcggtaa catatactgg gtgcgcgact 16560 cggtaagcgg cacacgggtg cccgtgcgct ttcgcccccc acggaattag cacaaaacaa 16620 catacacact gagtctcctg ctgttgtgta tcccagcggc gaccgtcagc agcggcgaca 16680 tgtccaagcg caaaattaaa gaagagatgc tccaggtcat cgcgccggag atctatgggc 16740 ccccgaagaa ggaggaggat gattacaagc cccgcaagct aaagcgggtc aaaaagaaaa 16800 agaaagatga tgacgttgac gaggcggtgg agtttgtccg ccgcatggcg cccaggcgcc 16860 ccgtgcagtg gaagggtcgg cgcgtgcagc gagtcctgcg ccccggcacc gcggtggtct 16920 ttacgcccgg cgagcgttcc acgcgcactt tcaagcgggt gtacgatgag gtgtacggcg 16980 acgaggatct gttggagcag gccaaccatc gctttgggga gtttgcatat gggaaacggc 17040 cccgcgagag cctaaaagag gacctgctgg cgctaccgct ggacgagggc aatcccaccc 17100 cgagtctgaa gccggtaacc ctgcaacagg tgctgccttt gagcgcgccc agcgagcaga 17160 agcgagggtt gaagcgcgag ggcggggacc tggcacccac cgtgcagttg atggtgccca 17220 agcggcagaa gctggaggac gtgctggaga aaatgaaagt agagcccggg atccagcccg 17280 aaatcaaggt ccgccccatc aagcaggtgg cgcccggcgt gggagtccag accgtggacg 17340 ttaggattcc cacggaggag atggaaaccc aaaccgccac tccctcttcg gcggctagcg 17400 ccaccaccgg cgccgcttcg gtagaggtgc agacggaccc ctggctacct gccgccactg 17460 tcgccgccgc cgccgccgcc ccccgttcgc gcgggcgcaa gagaaattat ccagcggcca 17520 gcgcgctcat gccccagtac gcactgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcacccgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcattg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg cctccgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcagag gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgctg 17940 cccttcctaa tcccgctaat cgccgcggcg atcggtgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc attttttgga 18060 ggaaaaaata aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagt ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggccaga tgctgagaga caagttgaaa gagcagaact tccaggaaaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccggcctcag gtggaggaaa cgcctccagc 18480 aatggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcctaccact cgccccatag cccccatggc caccggtgtg gtgggacaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgatccgcct cgccagccaa aggcggcgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgccc ctgcgccgcg ctgcaagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gtttatcccc gtggatcggg 19200 aggacaccgc ctactcttac aaggcgcggt ttacgctggc cgtgggcgac aatcgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggtcg ctgcagatga ggacctggaa gaagatgaag 19440 aagcgcaagc agaagagcaa gcccctgtta aaaaaattca tgtatatgct caggcgcctc 19500 ttgctggcga aaagattacc aaggatggtt tgcaaatagg tactgaagtc gtaggagata 19560 catctaagga cacttttgca gataaaacat tccaacccga acctcagata ggcgagtctc 19620 agtggaacga ggctgatgcc acagcagcag gaggtagagt tttgaaaaag actaccccta 19680 tgagaccttg ctatggatcc tatgccaggc ctaccaatgc caacgggggt caaggaatta 19740 tggttgccaa tgaacaagga gtgttgcagt ctaaagtaga aatgcaattt ttctctaaca 19800 cctcaaccct taatgcgcgg gatggaaccg gcaatcccga accaaaggtg gtgttgtaca 19860 gcgaagatgt ccacttggaa tctcccgata ctcatctgtc ttacaagccc aaaaaggatg 19920 atgttaatgc caaagtcatg ttgggtcagc aagccatgcc caacagaccc aacctcattg 19980 gatttagaga taatttcatt gggcttatgt tttacaacag caccggtaac atgggagtgc 20040 tggcgggtca ggcctctcag ttgaatgctg tggtggactt gcaggataga aacacagaac 20100 tgtcatatca gcttatgctt gattcaattg gggatagaac cagatacttc tccatgtgga 20160 accaggcagt ggatagctat gatccagatg tcagaattat tgaaaaccat ggggttgagg 20220 atgaactgcc caactactgc ttccctttgg gcggcatagg aattactgat acttatcaag 20280 gggtgaaaaa tagcaatggc aatggtcagt ggaccaaaga tgatcagttc gcggaccgca 20340 acgaaatagg ggtgggaaac aacttcgcca tggagatcaa catccaggcc aacctttgga 20400 gaaacttcct ctatgcaaac gtggggctct acctgccaga caagctcaag tacaacccca 20460 ccaacgtgga catctctgac aaccccaaca cctatgacta catgaacaag cgggtggtgg 20520 cccctggcct ggtggactgc tttgtcaatg tgggagccag gtggtccctg gactacatgg 20580 acaacgtcaa ccccttcaac caccaccgca atgcgggtct gcgctaccgc tccatgatcc 20640 tgggcaacgg gcgctatgtg ccctttcaca tccaggtacc ccagaagttc tttgccatca 20700 agaacctcct gctcctgccc ggctcctaca cctacgagtg gaacttcagg aaggatgtga 20760 acatggtcct acagagctct ctgggcaatg accttagggt ggatggggcc agcatcaagt 20820 ttgacagcat caccctctat gctacatttt tccccatggc ccacaacacc gcctccacgc 20880 ttgaggccat gctgagaaac gacaccaacg accagtcctt taatgactac ctctctgggg 20940 ccaacatgct ctacccaatc ccagccaagg ccaccaacgt gcccatctcc atcccctctc 21000 gcaactgggc cgcctttaga ggctgggcct ttacccgcct taagaccaag gagaccccct 21060 ccctgggctc gggttttgat ccctactttg tttactcggg atccatcccc tacctggatg 21120 gcaccttcta cctcaaccac actttcaaga agatatccat catgtatgac tcctccgtca 21180 gctggccggg caacgaccgc ttgctcaccc ccaatgagtt cgaggtcaag cgcgccgtgg 21240 acggcgaggg ctacaacgtg gcccagtgca acatgaccaa ggactggttc ctggtgcaga 21300 tgctggccaa ctacaacata ggctaccagg gcttttacat cccagagagc tacaaggaca 21360 ggatgtactc cttcttcaga aatttccaac ccatgagccg acaggtggtg gacgagacca 21420 attacaagga ctatcaagcc attggcatca cccaccagca caacaactcg ggtttcgtgg 21480 gctacctggc gcccaccatg cgcgagggtc aggcctaccc cgccaacttc ccctacccct 21540 tgataggcaa gaccgcggtc gacagcgtca cccagaaaaa gttcctctgc gaccgcaccc 21600 tctggcgcat ccccttctct agcaacttca tgtccatggg tgcgctcacg gacctgggcc 21660 aaaacctgct ttatgccaac tctgcccatg cgctggacat gactttcgag gtggacccca 21720 tggacgagcc cacccttctc tatattgtgt ttgaagtgtt cgacgtggtc agagtgcacc 21780 agccgcaccg cggtgtcatc gagaccgtgt acctgcgtac gcccttctca gccggcaacg 21840 ccaccaccta aggagacagc gccgccgcct gcatgactgg ttccaccgag caagagctca 21900 gggccatcgc cagagacctg ggatgcggac cctacttttt gggcacctat gacaaacgct 21960 tcccgggttt catctcccga gacaagctcg cctgcgccat cgtcaacacg gccgcgcgcg 22020 agaccggggg cgtgcactgg ctggcctttg gctgggaccc gcgctctaaa acttgctacc 22080 tctttgaccc ctttggcttc tctgatcagc gcctcaggca gatttatgag tttgagtacg 22140 aggggctgct gcgccgcagc gcgcttgcct cctcgcccga ccgctgcatc acccttgaga 22200 agtccaccga gaccgtgcag gggccccact cggccgcctg cggtctcttc tgttgcatgt 22260 ttttgcacgc ctttgtacac tggcctcaga gtcccatgga tcgcaacccc accatgaact 22320 tgctaaaggg agtgcccaac gccatgctcc agagccccca ggtcctgccc accctgcgcc 22380 gcaaccagga acagctctac cgcttcctgg agcgccactc cccctacttc cgcagccaca 22440 gcgcgcgcat ccggggggcc acctcttttt gccacttgca agaaaacatg caagacggaa 22500 aatgatgtac agcatgcttt taataaatgt aaagactgtg cactttattt atacacgggc 22560 tctttctggt tatttattca acaccgccgt cgccatctag aaatcgaaag ggttctgccg 22620 cgcgtcgccg tgcgccacgg gcagagacac gttgcgatac tggaagcggc tcgcccactt 22680 gaactcgggc accaccatgc ggggcagtgg ttcctcgggg aaattctcgc tccacagggt 22740 gcgggtcagc tgcagcgcgc tcaggaggtc gggagccgag atcttgaagt cgcagttggg 22800 gccggaaccc tgcgcgcgcg agttgcggta cacggggttg cagcactgga acaccagcag 22860 ggccggatta ttcacgctgg ccagcaggct ctcgtcgctg atcatgtcgc tgtccagatc 22920 ctccgcgttg ctcagggcga atggggtcat cttgcagacc tgcctgccca ggaaaggcgg 22980 gagcccaggc ttgccgttgc agtcgcagcg caggggcatt agcaggtgcc cacggcccga 23040 ctgcgcctgc gggtacaacg cgcgcatgaa ggcttcgatc tgcctaaaag ccacctgggt 23100 cttggctccc tccgaaaaga acatcccaca ggacttgctg gagaactgat tcgcgggaca 23160 gctggcatcg tgcaggcagc agcgcgcgtc agtgttggcg atctgcacca cgttgcgacc 23220 ccaccggttt ttcactatct tggccttgga agcctgctcc tttagcgcgc gctggccgtt 23280 ctcgctggtc acatccatct ctatcacctg ttccttgttg atcatgtttg tcccgtgcag 23340 acactttagg tcgccctccg tctgggtgca gcggtgctcc cacagcgcgc aaccggtggg 23400 ctcccaattc ttgtgggtca cccccgcgta ggcctgcagg taggcctgca ggaagcgccc 23460 catcatggtc ataaaggtct tctggctcgt aaaggtcagc tgcaggccgc gatgctcttc 23520 gttcagccag gtcttgcaga tggcggccag cgcctcggtc tgctcgggca gcatcttaaa 23580 atttgtcttc aggtcgttat ccacgtggta cttgtccatc atggcacgcg ccgcctccat 23640 gcccttctcc caggcggaca ccatgggcag gcttaggggg tttatcactt ccagcggcga 23700 ggacaccgta ctttcgattt cttcttcctc cccctcttcc cggcgcgcgc ccccgctgtt 23760 gcgcgctctt accgcctgca ccaaggggtc gtcttcaggc aagcgccgca ccgagcgctt 23820 gccgcccttg acctgcttga tcagtaccgg cgggttgctg aagcccacca tagtcagcgc 23880 cgcctgctct tcttcgtctt cgctgtctac cactatttct ggggaggggc ttctccgctc 23940 tgcggcaaag gcggcggatc gcttcttttt tttcttggga gccgccgcga tggagtccgc 24000 cacggcgacc gaggtcgagg gcgtggggct gggggtgcgc ggcaccaggg cctcgtcgcc 24060 ctcggactct tcctctgact ccaggcggcg gcggagtcgc ttctttgggg gcgcgcgcgt 24120 cagcggcggc ggagacgggg acggggacgg ggacgggacg ccctccacag ggggcggtct 24180 tcgcgcagac ccgcggccgc gctcgggggt cttctcgcgc tggtcttggt cccgactggc 24240 cattgtatcc tcctcctcct aggcagagag acataaggag tctatcatgc aagtcgagaa 24300 ggaggagagc ttaaccaccc cctctgagac cgccgtcgcc gtcgcccccg ctaccgccga 24360 cgcgcccgcc acaccgagcg acacccccgc ggaccccccc gccgacgcac ccctgttcga 24420 ggaagcggcc gtggagcagg acccgggctt tgtctcggca gaggaggatt tgcaagagga 24480 ggaggataag gaggagaagc cctcagtgcc aaaagatcat aaagagcaag acgagcacga 24540 cgcagacgca caccagggtg aagtcgggcg gggggacgga gggcatggcg gcgccgacta 24600 cctagacgaa ggaaacgacg tgctcttgaa gcacctgcat cgtcagtgcg ccatcgtctg 24660 cgacgctctg caggagcgca gcgaggtgcc cctcagcgtg gcggaggtca gccgcgccta 24720 cgagctcagc ctcttttccc cccgggtgcc cccccgccgc cgcgaaaacg gcacatgcga 24780 gcccaacccg cgcctcaact tctaccccgc ctttgtggtg cccgaggtcc tggccaccta 24840 tcacatcttc tttcaaaatt gcaagatccc catctcgtgc cgcgccaacc gtagccgcgc 24900 cgataagatg ctggccctgc gccagggcga ccacatacct gatatcgccg ctttggaaga 24960 tgtaccaaag atcttcgagg gtctgggtcg caacgaaaag cgggcagcaa actctctgca 25020 acaggaaaac agcgaaaatg agagtcacac cggggtgctg gtggagctcg agggcgacaa 25080 cgcccgcctg gcggtgctca agcgcagcat cgaggtcacc cactttgcct accccgcgct 25140 caacctgccc cccaaagtca tgaacgcggt catggacggg ctgatcatgc gccgcggcca 25200 gccccttgct ccagatgcaa acttgcatga ggagaccgag gacggccagc ccgtggtcag 25260 cgacgagcag ctggcgcgct ggctggaaac cgcggacccc gccgaactgg aggagcggcg 25320 caagatgatg atggccgcgg tgctggtcac cgtagagctg gagtgtctgc agcgcttctt 25380 cggtgacccc gagatgcaga gaaaggtcga ggagacccta cactacacct tccgccaggg 25440 ctacgtgcgc caggcttgca agatctccaa cgtggagctc agcaacctgg tgtcctacct 25500 gggcatcttg catgagaacc gccttgggca gagcgtgctg cactccaccc tgcgcgggga 25560 agcgcgccgc gactacgtgc gcgactgcgt ttaccttttc ctctgctaca cctggcagac 25620 ggccatgggg gtctggcagc agtgcctgga ggagcgcaac ctcaaggagc tggagaagct 25680 cctgcagcgc gcgctcaaag acctctggac gggcttcaac gagcgctcgg tggccgccgc 25740 gctggccgac ctcatcttcc ccgagcgcct gctcaaaact ctccagcagg ggctgcccga 25800 cttcaccagc caaagcatgt tgcaaaactt taggaacttt atcctggagc gttctggcat 25860 cctacccgcc acctgctgcg ccctgcccag tgactttgtt cccctcgtgt accgcgagtg 25920 ccccccgccg ctgtggggcc actgctacct gttccaactg gccaactacc tgtcctacca 25980 cgcggacctc atggaggact ccagcggcga ggggctcatg gagtgccact gccgctgcaa 26040 cctctgcacg ccccaccgct ccctggtctg caacacccaa ctgctcagcg agagtcagat 26100 tatcggtacc ttcgagctac agggtccgtc ctcctcagac gagaagtccg cggctccggg 26160 gctaaaactc actccggggc tgtggacttc cgcctacctg cgcaaatttg tacctgaaga 26220 ctaccacgcc cacgagatca ggttttacga ggaccaatcc cgcccgccca aggcggagct 26280 gaccgcctgc gtcatcaccc agggcgagat cctaggccaa ttgcaagcca tccaaaaagc 26340 ccgccaagag tttttgctga gaaagggtcg gggggtgtat ctggaccccc agtcgggtga 26400 ggagctcaac ccggttcccc cgctgccgcc gccgcgggac cttgcttccc aggataagca 26460 tcgccatggc tcccagaaag aagcagcagc ggccgccact gccgccaccc cacatgctgg 26520 aggaagagga gtactgggac agtcaggcag aggaggtttc ggacgaggag gagccggaga 26580 cggagatgga agagtgggag gaggacagct tagacgagga ggcttccgaa gccgaagagg 26640 caggcgcaac accgtcaccc tcggccgcag ccccctcgca ggcgcccccg aagtccgctc 26700 ccagcatcag cagcaacagc agcgctataa cctccgctcc tccaccgccg cgacccacgg 26760 ccgaccgcag acccaaccgt agatgggaca ccaccggaac cggggccggt aagtcctccg 26820 ggaaaggcaa gcaagcgcag cgccaaggct accgctcgtg gcgcgctcac aagaacgcca 26880 tagtcgcttg cttgcaagac tgcgggggga acatctcctt cgcccgccgc ttcctgctct 26940 tccaccacgg tgtggccttc ccccgtaacg tcctgcatta ctaccgtcat ctctacagcc 27000 cctactgcgg cggcagtgag ccagaggcgg ccggcggcag cggcgcccgt ttcggtgcct 27060 aggaagaccc agggcaagac ttcagccaag aaactcgcgg cggccgcggc gaacgcggtc 27120 gcgggggccc tgcgcctgac ggtgaacgaa cccctgtcga cccgcgaact gaggaaccga 27180 atcttcccca ctctctatgc catcttccag cagagcagag ggcaggatca ggaactgaaa 27240 gtaaaaaaca ggtctctgcg ctccctcacc cgcagctgtc tgtatcacaa gagcgaagac 27300 cagcttcggc gcacgctgga ggacgctgag gcactcttca gcaaatactg cgcgctcact 27360 cttaaggact agctccgcgc ccttctcgaa tttaggcggg aacgcctacg tcatcgcagc 27420 gccgccgtca tgagcaagga cattcccacg ccatacatgt ggagctatca gccgcagatg 27480 ggactcgcgg cgggcgcctc ccaagactac tccacccgca tgaactggct cagtgccggc 27540 ccacacatga tctcacaggt taatgacatc cgcacccatc gaaaccaaat attggtggag 27600 caggcggcaa ttaccaccac gccccgcaat aatcccaacc ccagggagtg gcccgcgtcc 27660 ctggtgtatc aggaaattcc cggccccacc accgtactac ttccgcgtga ttcccaggcc 27720 gaagtccaaa tgactaactc aggggcacag ctcgcgggcg gctgtcgtca cagggtgcgg 27780 cctcctcgcc agggtataac tcacctggag atccgaggca gaggtattca gctcaacgac 27840 gagtcggtga gctcctcgct cggtctcaga cctgacggga ccttccagat agccggagcc 27900 ggccgatctt ccttcacgcc ccgccaggcg tacctgactc tgcagagctc gtcctcggcg 27960 ccgcgctcgg gcggcatcgg gactctccag ttcgtgcagg agtttgtgcc ctcggtctac 28020 ttcaacccct tctcgggctc tcccggtcgc tacccggacc agttcatccc gaactttgac 28080 gccgcgaggg actcggtgga cggctacgac tgaatgtcgg gtggacccgg tgcagagcaa 28140 cttcgcctga agcaccttga ccactgccgc cgccctcagt gctttgcccg ctgtcagacc 28200 ggtgagttcc agtacttttc cctgcccgac tcgcacccgg acggcccggc acacggggtg 28260 cgctttttca tcccgagtca ggtccgctct accctaatca gggagtttac agcccgtccc 28320 ctactggcgg agttggaaaa ggggccttct atcctaacca ttgcctgcat ctgctctaac 28380 cctggattac accaagatct ttgctgtcat ttgtgtgctg agtataataa aggctgagat 28440 cagaatctac tcgggctcct gtcgccatcc tgtcaacgcc accgtccaag cccggcccga 28500 tcagcccgag gtgaacctca cctgcggtct gcaccggcgc ctgaggaaat acctagcttg 28560 gtactacaac agcactccct ttgtggttta caacagcttt gaccaggacg gggtctcact 28620 gagggataac ctctcgaacc tgagctactc catcaggaag aacaacaccc tcgagctact 28680 tcctccttac ctgcccggga cttaccagtg tgtcaccggt ccctgcaccc acacccacct 28740 gttgatcgta aacgactctc ttccgagaac agacctcaat aactcctctc cgcagttccc 28800 cagaacagga ggtgagctca ggaaaccccg ggtaaagaag ggtggacaag agttaacact 28860 tgtggggttt ctggtgtatg tgacgctggt ggtggctctt ttgattaagg cttttccttc 28920 catgtctgaa ctctccctct tcttttatga acaactcgac tagtgctaac gagaccctac 28980 ccaacgaatc gggattgaat atcggtaacc aggttgcagt ttcacttttg attaccttta 29040 tagtcctctt cctgctagtg ctgtcgcttc tgtgcctgcg gatcgggggc tgctgcatcc 29100 acgtttatat ctggtgctgg ctgtttagaa ggttcggaga ccaccgcagg tagaataatg 29160 ctgcttaccc tctttgtcct ggcgctggct gccagctgcc aagccttttc cgaggctgac 29220 ttcatagagc cccagtgcaa tatcacttat aaatctgaac gtgccatctg tactatccta 29280 atcaaatgtg ttactcaaca cgataaggta actgttaaat acaaagatca attaaaaaaa 29340 gacgcacttt acagcagctg gcaaccagga gatgaacaaa aatacaatgt aaccgtcttc 29400 cagggcaaac tctccaaaac ttacaattac actttcccat ttgagcagat gtgtgacttt 29460 gtcatgtaca tggaaaagca gtacaagctg tggcctccaa ctccccaggg ctgtgtggaa 29520 aatccaggct ctttctgtat gatctctctc tgtgtaactg tgctggcact aatactcacg 29580 cttctgtata tcagatttaa atcaaggcaa agctttattg atgaaaagaa aatgccttaa 29640 tcgctttcac gcttgattgc taacaccggg tttttatccg cagaatgatt ggaatcaccc 29700 tactaatcac ctccctcctt gcgattgccc atgggttgga acgaatcgaa gtccctgtgg 29760 gggccaatgt taccctggtg gggcctgtcg gcaatgctac attaatgtgg gaaaaatata 29820 ctaaaaatca atgggtctct tactgcacta acaaaaacag ccacaagccc agagccatct 29880 gcgatgggca aaatttaacc ttgattgatg ttcaattgct ggatgcgggc tactattatg 29940 ggcagctggg tacaatgatt aattactgga gaccccacag agattacatg cttcacgtag 30000 taaagggtcc cattagcagc ccaaccacca cctctaccac ccccactacc accactactc 30060 ccaccaccag cactgccgcc cagcctcctc atagcagaac aaccactttt atcaattcca 30120 agtcccactc cccccacatt gccggcgggc cctccgcctc agactccgag accaccgaga 30180 tctgcttctg caaatgctct gacgccattg cccaggattt ggaagatcac gaggaagatg 30240 agcatgacta cgcagatgca tgccaggcat cagagtcaga agcgctgccg gtggccctaa 30300 aacagtatgc agacccccac accacccccg accttcctcc accttcccag aagccaagtt 30360 tcctggggga aaatgaaact ctgcctctct ccatactagc tctgacatct gttgctattt 30420 tggccgctct gctggtgctt ctatgctcta tatgctacct gatctgctgc agaaagaaaa 30480 aatctcacgg ccatgctcac cagcccctca tgcacttccc ttaccctcca gagctgggcg 30540 accacaaact ttaagtctgc agtagctatc tgcccatccc ttgtcagtcg acagcgatga 30600 gccccactaa tctaacagcc tctggactta caacattgtc tcttaatgag accaccgctc 30660 ctcaagacct gtacgatggt gtctccgcgc tggttaacca gtgggatcac ctgggcatat 30720 ggtggctcct cataggagca gtgaccctgt gcctaatcct ggtctggatc atctgctgca 30780 tcaaaagcag aagacccagg cggcggccca tctacaggcc cttcgtcatc acacctgaag 30840 ataatgatga tgatgacacc acctccaggc tgcagagcct aaagcagcta ctcttctctt 30900 ttacagcatg gtaaattgaa tcatgccccg cattttcatc tacttgcttc tccttccact 30960 ttttctgggc tcctctacat tggccgctgt gtcccacatc gaggtagact gcctcacgcc 31020 cttcacagtc tacctgcttt tcggctttgt catctgcacc tttgtctgca gcgttatcac 31080 tgtagtgatc tgcttcatac agtgcatcga ctacatctgt gtgcgggtgg cctactttag 31140 acaccacccc cagtatcgca acagggacat agcggctctc ctaagacttg tttaaatcat 31200 ggccaaatta cctgtgattg gtcttctgat tatctgctgc gtcctagccg cgattgggac 31260 tcaacctaat accaccacca gcgctcccag aaagagacat gtatcctgca gcttcaagcg 31320 tccctggaat ataccccaat gctttactga tgaacctgaa atctctttgg cttggtactt 31380 cagcgtcacc gcccttctca tcttctgcag tacggttatt gctcttgcca tctacccttc 31440 ccttaacctg ggctggaatg ctgtcaactc tatggaatat cccaccttcc cagaaccaga 31500 cctgccagac ctggttgttc taaacgcgtt tcctcctcct ccagttcaaa atcagtttcg 31560 ccctccgtcc cctacgccca ctgaggtcag ctactttaat ctaacaggcg gagatgactg 31620 aaaacctaga cctagaaatg gacggtctct gcagcgagca acgcacacta gagaggcgcc 31680 ggcaaaaagc agagctcgag cgtcttaaac aagagctcca agacgccgtg gccatacacc 31740 agtgcaaaaa agggctcttc tgtctggtaa aacaggccac gctcacctat gaaaaaacag 31800 gtgacaccca ccgcctagga tacaagctgc ccacacagcg ccaaaagttt gcccttatga 31860 taggtgaaca acccatcacc gtcacccagc actccgtgga gacagaaggc tgcattcatg 31920 ctccctgcag gggcgctgac tgcctctaca ccttgatcaa aaccctctgc ggtctcagag 31980 accttatccc tttcaattga tcataactgt aatcaataaa aaatcactta cttgaaatct 32040 gatagcaagc ctctgtccaa ttttttcagc aacacttcct tcccctcttc ccaactctgg 32100 tactctaggc gcctcctagc tgcaaacttc ctccacagtc tgaagggaat gtcagattcc 32160 tcctcctcct gtccctccgc acccacaatc ttcatgttgt tgcagatgaa acgcgcgaga 32220 tcgtctgacg agaccttcaa ccccgtgtac ccctacgata ccgagatcgc tccgacttct 32280 gtccctttcc ttacccctcc ctttgtgtca cccgcaggaa tgcaagaaaa tccagctggg 32340 gtgctgtccc tgcacctgtc agagcccctt accacccaca atggggccct gactctaaaa 32400 atggggggcg gcctgaccct ggacaaggaa gggaatctca cttcccaaaa catcaccagt 32460 gtcgatcccc ctctcaaaaa aagcaagaac aacatcagcc ttcagaccgc cgcacccctc 32520 gccgtcagct ccggggccct aacccttttt gccactcccc ccctagcggt cagtggcgac 32580 aaccttactg tgcagtctca ggcccctctt actttggaag actcaaaact aactctggcc 32640 accaaaggac ccctaactgt gtccgaaggc aaacttgtcc tagaaacaga ggctcccctg 32700 catgcaagtg acagcagtag cctgggcctt agcgtcacgg ccccacttag cattaacaat 32760 gacagcctag gactagatct gcaggcaccc attgtctctc aaaatggaaa actggctcta 32820 aatatagcag gccccctagc tgtagccgat agcattaatg ctttgacagt aggcactggc 32880 aaaggtattg gactaaatga aaccagcact cacttgcaag caaaattggt tgccccccta 32940 ggctttgata ccaatggcaa tattaagcta agcgttgcag gaggcatgag gctaaacaat 33000 gacacactga tactagatgt aaactaccca tttgaagctc aaggtcaact aagcctaaga 33060 gtgggcacag gtccactgta tgtagattct agcagtcata atctaaccat tagatgcctt 33120 aggggattgt atataacatc atctaacaac caaaacggtc tagaggccaa cattaaacta 33180 acaaaaggcc ttgtgtatga aggaaatgcc atagcagtta atgttggtca aggattgcaa 33240 tacagcacta ctgccacatc ggaaggtgtg tatcctatac agtctaagat aggtttggga 33300 atggaatatg ataccaacgg agccatgatg gcaaaactag gctccggtct aagctttgat 33360 aattcaggag ccattgtggt gggaaacaaa aatgatgaca aacttaccct atggaccaca 33420 cctgacccgt ctcctaactg tagaatttat tctgaaaaag atactaaact aaccttggtg 33480 ctgactaagt gtggcagtca aatcctaggc acagtatctg cccttgctgt cagaggcagc 33540 cttgcgccca tcactaacgc atccagcata gtccaaatat ttctacgatt tgatgaaaat 33600 ggactattga tgagcaactc atcgctagac ggtgattact ggaattacag aaatggggac 33660 tccactaatg gcacaccata tacaaatgca gtaggcttta tgcctaatct agctgcctat 33720 cctaaaggtc aggctacaac tgcaaaaagc agtattgtaa gccaggtata catggatggt 33780 gatactacta aacctataac actaaaaata aactttaatg gcattgatga aacaacagaa 33840 aatacccctg ttagtaaata ttccatgaca ttctcatgga gctggcccac cgcaagctac 33900 ataggccaca cttttgcaac aaactctttt actttctcct acatcgccca agaataaaga 33960 aagcacagag atgcttgttt ttgatttcaa aattgtgtgc ttttatttat tttcaagctt 34020 acagtatttc cagtagtcat tcaaatagag cttaatgaaa ctgcatgaga acccttccac 34080 atagcttaaa ttatcaccag tgcaaatgga gaaaaaatca acataccttt ttatccagat 34140 atcatagaac tctagtggtc agttttcccc caccctccca gctcacagaa tacacagtcc 34200 tttccccccg gctggcttta aacaacacta tctcattggt aacagacata ttcttaggtg 34260 taataatcca cacggtctct tggcgggcca aacgctggtc agtgatgtta ataaactccc 34320 caggcagctc tttcaagttc acgtcgctgt ccaactgctg aagcgctcgc ggctccgact 34380 gcgcctctag cggaggcaac ggcaacaccc gatccttgat ctataaagga gtagagtcat 34440 aatcccccat aagaataggg cggtgatgct gcaacaaggc gcgcagcaac tcctgccgcc 34500 gcctttccgt acgacaggaa tgcaacgggg tggtggtctc ctccgcgata atccgcaccg 34560 ctcgcaacat cagcgtcctc gtcctccggg cacagcagcg catcctgatc tcactgagat 34620 cggcgcagta agtgcagcac aacaccaaga tgttatttaa gatcccacag tgcaaagcac 34680 tgtacccaaa gctcatggcg ggaaggacag cccccacgtg accatcatac cagatcctca 34740 ggtaaatcaa atgacgacct ctcatgaaca cgctggacat gtacatcacc tccttaggca 34800 tgtgctgatt caccacctct cgataccaca ggcatcgctg attaattaaa gacccctcga 34860 gcaccatcct gaaccaggaa gccagcacct gaccccccgc caggcactgc agggaccccg 34920 gtgaatcgca gtggcagtga agactccagc gctcgtagcc gtgaaccata gagctggtca 34980 ttatatccac attggcacaa cacagacaca ctttcataca ctttttcatg attagcagct 35040 cctctctagt caggaccata tcccaaggaa tcacccactc ttgaatcaag gtaaatccca 35100 cacagcaggg caggcctctc acataactca cgttatgcat agtgagcgtg tcgcaatctg 35160 gaaataccgg atgatcttcc atcaccgaag cccgggtctc cgtctcaaag ggaggtaaac 35220 ggtccctcgt gtagggacag tggcgggata atcgagatcg tgttgaacgt agagtcatgc 35280 caaagggaac agcggacgta ctcatatttc ctccagcaga accaagtgcg cgcgtggcag 35340 ctatccttgc gtcttctgtc tcgccgcctg ccccgctcgg tgtagtagtt gtaatacagc 35400 cactccctca gaccgtcaag gcgctccctg gcgtccggat ctataacaac accatcctgc 35460 agcgccgccc tgatgacatc caccaccgta gagtatgcca agcccagcca ggaaatgcac 35520 tcactttgac agcgagagat aggaggagcg ggaagagatg gaagaaccat gatagtaaaa 35580 gaacttttat tccaatcgat cctctacaat gtcaaagtgt agatctatca gatggcactg 35640 gtctcctccg ctgagtcgat caaaaataac agctaaacca caaacaacac gattggtcaa 35700 atgctgcaca agggcttgca gcataaaatc gcctcgaaag tccaccgcaa gcataacatc 35760 aaagccaccg cccctatcat gatctatgat aaaaacccca cagctatcca ccagacccat 35820 atagttttca tctctccatc gtgaaaaaat atttacaagc tcctccttta aatcacctcc 35880 aaccaattca aaaagttgag ccagaccgcc ctccaccttc attttcagca tgcgcatcat 35940 gattgcaaaa attcaggctc ctcagacacc tgtataagat tgagaagcgg aacgttaaca 36000 tcaatgtttc gctcgcgaag atcgcgcctc agtgcaagca tgatataatc ccacaggtcg 36060 gagcggatca gcgaggacat ctccccgcca ggaaccaact caacggagcc tatgctgatt 36120 ataatacgca tattcggggc tatgctaacc agcacggccc ccaaataggc gtactgcata 36180 ggcggcgaca aaaagtgaac agtttgggtt aaaaaatcag gcaaacactc gcgcaaaaaa 36240 gcaagaacat cataaccatg ctcatgcaaa tagatgcaag taagctcagg aacgaccaca 36300 gaaaaatgca caatttttct ctcaaacatg actgcgagcc ctgcaaaaat aaaaaagaaa 36360 cattacacaa gagtagcctg tcttacaatg ggatagacta ctctaaccaa cataagacgg 36420 gccacaacat cgcccgcgtg gccataaaaa aaattatccg tgtgattaaa aagaagcaca 36480 gatagctggc cagtcatatc cggagtcatc acgtgcgaac ccgtgtagac ccccgggttg 36540 gacacatcgg ccaaacaaag aaagcggcca atgtatcccg gaggaatgat aacactaaga 36600 cgaagataca acagaataac cccatggggg ggaataacaa agttagtagg tgaataaaaa 36660 cgataaacac ccgaaactcc ctcctgcgta ggcaaaatag cgccctcccc ttccaaaaca 36720 acatatagcg cttccacagc agccatgaca aaagactcaa aacactcaaa agactcagtc 36780 ttaccaggaa aataaaagca ctctcacagc accagcacta atcagagtgt gaaaaaggcc 36840 aagtgccgaa cgagtatata taggaattaa aaatgacgta aatgtgtaaa ggtcagaaaa 36900 cgcccagaaa aatacacaga ccaacgcccg aaacgaaaac ccgcgaaaaa atacccagaa 36960 gttcctcaac aaccgccact tccgctttcc cacgagacgt cacttcctca aaaatagcaa 37020 actacatttc ccacatatac aaaaccaaaa cccctcccct tgtcaccgcc cacaacttac 37080 atcatcacaa acgtcaaagc ctacgtcacc cgccccgccc acctcattat catattggcc 37140 acaatccaaa ataaggtata ttattgatga tg 37172 <210> 7 <211> 37187 <212> DNA <213> Great Ape Adenovirus <400> 7 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggtcg ctgcagatga ggacctggaa gaagatgaag 19440 aagcgcaagc agaagagcaa gcccctgtta aaaaaattca tgtatatgct caggcgcctc 19500 ttgctggcga aaagattacc aaggatggtt tgcaaatagg tactgaagtc gtaggagata 19560 catctaagga cacttttgca gataaaacat tccaacccga acctcagata ggcgagtctc 19620 agtggaacga ggctgatgcc acagcagcag gaggtagagt tttgaaaaag actaccccta 19680 tgagaccttg ctatggatcc tatgccaggc ctaccaatgc caacgggggt caaggaatta 19740 tggttgccaa tgaacaagga gtgttgcagt ctaaagtaga aatgcaattt ttctctaaca 19800 cctcaaccct taatgcgcgg gatggaaccg gcaatcccga accaaaggtg gtgttgtaca 19860 gcgaagatgt ccacttggaa tctcccgata ctcatctgtc ttacaagccc aaaaaggatg 19920 atgttaatgc caaagtcatg ttgggtcagc aagccatgcc caacagaccc aacctcattg 19980 gatttagaga taatttcatt gggcttatgt tttacaacag caccggtaac atgggagtgc 20040 tggcgggtca ggcctctcag ttgaatgctg tggtggactt gcaggataga aacacagaac 20100 tgtcatatca gcttatgctt gattcaattg gggatagaac cagatacttc tccatgtgga 20160 accaggcagt ggatagctat gatccagatg tcagaattat tgaaaaccat ggggttgagg 20220 atgaactgcc caactactgc ttccctttgg gcggcatagg aattactgat acttatcaag 20280 gggtgaaaaa tagcaatggc aatggtcagt ggaccaaaga tgatcagttc gcggaccgca 20340 acgaaatagg ggtgggaaac aacttcgcca tggagatcaa catccaggcc aacctttgga 20400 gaaacttcct ctatgcaaac gtggggctct acctgccaga caagctcaag tacaacccca 20460 ccaacgtgga catctctgac aaccccaaca cctatgacta catgaacaag cgggtggtgg 20520 cccctggcct ggtggactgc tttgtcaatg tgggagccag gtggtccctg gactacatgg 20580 acaacgtcaa ccccttcaac caccaccgca atgcgggtct gcgctaccgc tccatgatcc 20640 tgggcaacgg gcgctatgtg ccctttcaca tccaggtacc ccagaagttc tttgccatca 20700 agaacctcct gctcctgccc ggctcctaca cctacgagtg gaacttcagg aaggatgtga 20760 acatggtcct acagagctct ctgggcaatg accttagggt ggatggggcc agcatcaagt 20820 ttgacagcat caccctctat gctacatttt tccccatggc ccacaacacc gcctccacgc 20880 ttgaggccat gctgagaaac gacaccaacg accagtcctt taatgactac ctctctgggg 20940 ccaacatgct ctacccaatc ccagccaagg ccaccaacgt gcccatctcc atcccctctc 21000 gcaactgggc cgcctttaga ggctgggcct ttacccgcct taagaccaag gagaccccct 21060 ccctgggctc gggttttgat ccctactttg tttactcggg atccatcccc tacctggatg 21120 gcaccttcta cctcaaccac actttcaaga agatatccat catgtatgac tcctccgtca 21180 gctggccggg caacgaccgc ttgctcaccc ccaatgagtt cgaggtcaag cgcgccgtgg 21240 acggcgaggg ctacaacgtg gcccagtgca acatgaccaa ggactggttc ctggtgcaga 21300 tgctggccaa ctacaacata ggctaccagg gcttttacat cccagagagc tacaaggaca 21360 ggatgtactc cttcttcaga aatttccaac ccatgagccg acaggtggtg gacgagacca 21420 attacaagga ctatcaagcc attggcatca cccaccagca caacaactcg ggtttcgtgg 21480 gctacctggc gcccaccatg cgcgagggtc aggcctaccc cgccaacttc ccctacccct 21540 tgataggcaa gaccgcggtc gacagcgtca cccagaaaaa gttcctctgc gaccgcaccc 21600 tctggcgcat ccccttctct agcaacttca tgtccatggg tgcgctcacg gacctgggcc 21660 aaaacctgct ttatgccaac tctgcccatg cgctggacat gacttttgag gtggacccca 21720 tggacgagcc cacccttctc tatattgtgt ttgaagtgtt cgacgtggtc agagtgcacc 21780 agccgcaccg cggtgtcatc gagaccgtgt acctgcgtac gcccttctca gccggcaacg 21840 ccaccaccta aggagacagc gccgccgccg cctgcatgac gggttccacc gagcaagagc 21900 tcagggccat tgccagagac ctgggatgcg gaccctattt tttgggcacc tatgacaaac 21960 gcttcccggg ctttatctcc cgagacaagc tcgcctgcgc cattgtcaac acggccgcgc 22020 gcgagaccgg gggcgtgcac tggctggcct ttggctggga cccgcgctcc aaaacttgct 22080 acctctttga cccctttggc ttctccgatc agcgcctcag gcagatttat gagtttgagt 22140 acgaggggct gctgcgccgc agcgcgctcg cctcctcgcc cgaccgctgc atcacccttg 22200 agaagtccac cgaaaccgtg caggggcccc actcggccgc ctgcggtctc ttctgttgca 22260 tgtttttgca cgcctttgtg cactggcctc agagtcccat ggattgcaac cccaccatga 22320 acttgctaaa gggagtgccc aacgccatgc tccagagccc ccaggtccag cccaccctgc 22380 gccgcaacca ggaacagctt taccgcttcc tggagcgcca ctccccctac ttccgcagcc 22440 acagcgcgcg catccggggg gccacctctt tttgccactt gcaagaaaac atgcaagacg 22500 gaaaatgatg tacagcatgc ttttaataaa tgtaaagact gtgcacttta attatacacg 22560 ggctctttct ggttatttat tcaacaccgc cgtcgccatt tagaaatcga aagggttctg 22620 ccgtgcgtcg ccgtgcgcca cgggcagaga cacgttgcga tactggaagc ggctcgccca 22680 cttgaactcg ggcaccacca tgcggggcag tggttcctcg gggaagttct cgctccacag 22740 ggtgcgggtc agctgcagcg cgctcaggag gtcgggagcc gagatcttga agtcgcagtt 22800 ggggccggaa ccctgcgcgc gcgagttgcg gtacacgggg ttgcagcact ggaacaccag 22860 cagggccgga ttattcacgc tggccagcag gctctcgtcg ctgatcatgt cgctgtccag 22920 atcctccgcg ttgctcaggg cgaatggggt catcttgcag acctgcctgc ccaggaaagg 22980 cgggagccca ggcttgccgt tgcagtcgca gcgcaggggc attagcaggt gcccacggcc 23040 cgactgcgcc tgcgggtaca acgcgcgcat gaaggcttcg atctgcctaa aagccacctg 23100 ggtcttggct ccctccgaaa agaacatccc acaggacttg ctggagaact ggttcgcggg 23160 acagctggca tcgtgcaggc agcagcgcgc gtcagtgttg gcaatctgca ccacgttgcg 23220 accccaccgg tttttcacta tcttggcctt ggaagcctgc tcctttagcg cgcgctggcc 23280 gttctcgctg gtcacatcca tctctatcac ctgttccttg ttgatcatgt ttgtcccgtg 23340 cagacacttt aggtcgccct ccgtctgggt gcagcggtgc tcccacagcg cgcaaccggt 23400 gggctcccaa ttcttgtggg tcacccccgc gtaggcctgc aggtaggcct gcaggaagcg 23460 ccccatcatg gtcataaagg tcttctggct cgtaaaggtc agctgcaggc cgcgatgctc 23520 ttcgttcagc caggtcttgc agatggcggc cagcgcctcg gtctgctcgg gcagcatctt 23580 aaaatttgtc ttcaggtcgt tatccacgtg gtacttgtcc atcatggcac gcgccgcctc 23640 catgcccttc tcccaggcgg acaccatggg caggcttagg gggtttatca cttccagcgg 23700 cgaggacacc gtactttcga tttcttcttc ctccccctct tcccggcgcg cgcccccgct 23760 gttgcgcgct cttaccgcct gcaccaaggg gtcgtcttca ggcaagcgcc gcaccgagcg 23820 cttgccgccc ttgacctgct tgatcagtac cggcgggttg ctgaagccca ccatggtcag 23880 cgccgcctgc tcttcttcgt cttcgctgtc taccactatt tctggggagg ggcttctccg 23940 ctctgcggca aaggcggcgg atcgcttctt ttttttcttg ggagccgccg cgatggagtc 24000 cgccacggcg accgaggtcg agggcgtggg gctgggggtg cgcggtacca gggcctcgtc 24060 gccctcggac tcttcctctg actccaggcg gcggcggagt cgcttctttg ggggcgcgcg 24120 cgtcagcggc ggcggagacg gggacgggga cggggacggg acgccctcca cagggggtgg 24180 tcttcgcgca gacccgcggc cgcgctcggg ggtcttctcg cgctggtctt ggtcccgact 24240 ggccattgta tcctcctcct cctaggcaga gagacataag gagtctatca tgcaagtcga 24300 gaaggaggag agcttaacca ccccctcaga gaccgccgat gcgcccgccg tcgccgtcgc 24360 ccccgctacc gccgacgcgc ccgccacacc gagcgacacc cccacggacc cccccgccga 24420 cgcacccctg ttcgaggaag cggccgtgga gcaggacccg ggctttgtct cggcagagga 24480 ggatttgcaa gaggaggaga ataaggagga gaagccctca gtgccaaaag atcataaaga 24540 gcaagacgag cacgacgcag acgcacacca gggtgaagtc gggcgggggg acggagggca 24600 tggcggcgcc gactacctag acgaaggaaa cgacgtgctc ttgaagcacc tgcatcgtca 24660 gtgcgccatc gtctgcgacg ctctgcagga gcgcagcgag gtgcccctca gcgtggcgga 24720 ggtcagccgc gcctacgagc tcagcctctt ttccccccgg gtgccccccc gccgccgcga 24780 aaacggcaca tgcgagccca acccgcgcct caacttctac cccgcctttg tggtgcccga 24840 ggtcctggcc acctatcaca tcttctttca aaattgcaag atccccatct cgtgccgcgc 24900 caaccgtagc cgcgccgata agatgctggc cctgcgccag ggcgaccaca tacctgatat 24960 cgccgctttg gaagatgtgc caaagatctt cgagggtctg gggcgcaacg agaagcgggc 25020 agcaaactct ctgcaacagg aaaacagcga aaatgagagt cacactggag cgctggtgga 25080 gctggagggc gacaacgccc gcctggcggt gctcaagcgc agcatcgagg tcacccactt 25140 tgcctacccc gcgctcaacc tgccccccaa agtcatgaac gcggtcatgg acgggctgat 25200 catgcgccgc ggccggcccc tcgctccaga tgcaaacttg catgaggaga ccgaggacgg 25260 tcagcccgtg gtcagcgacg agcagctgac gcgctggctg gagagcgcgg accccgccga 25320 actggaggag cggcgcaaga tgatgatggc cgcggtgctg gtcaccgtag agctggagtg 25380 tctgcagcgc ttcttcggtg accccgagat gcagagaaag gtcgaggaga ccctacacta 25440 caccttccgc cagggctacg tgcgccaggc ttgcaagatc tccaacgtgg agctcagcaa 25500 cctggtgtcc tacctgggca tcttgcatga aaaccgcctt gggcagagcg tgctacactc 25560 caccctgcgc ggggaggcgc gccgcgacta cgtgcgcgac tgcgtttacc tcttcctctg 25620 ctacacctgg cagacggcca tgggggtctg gcagcagtgc ctggaggagc gcaacctcaa 25680 ggagctggag aagcttctgc agcgcgcgct caaagacctc tggacgggct tcaacgagcg 25740 ctcggtggcc gccgcgctag ccgacctcat cttccccgag cgcctgctca aaaccctcca 25800 gcaggggctg cccgacttca ccagccaaag catgttgcaa aattttagga actttatcct 25860 ggagcgttct ggcatcctac ccgccacctg ctgcgccctg cccagcgact ttgtccccct 25920 cgtgtaccgc gagtgccccc cgccgctgtg gggccactgc tacctgttcc aactggccaa 25980 ctacctgtcc taccacgcgg acctcatgga ggactccagc ggcgaggggc tcatggagtg 26040 ccactgccgc tgcaacctct gcacgcccca ccgctccctg gtctgcaaca cccaactgct 26100 cagcgagagt cagattatcg gtaccttcga gctacagggt ccgtcctcct cagacgagaa 26160 gtccgcggct ccggggctaa aactcactcc ggggctgtgg acttccgcct acctgcgcaa 26220 atttgtacct gaagactacc acgcccacga aatcaggttt tacgaggacc aatcccgccc 26280 gcccaaggcg gagctgaccg cctgcgtcat cacccagggc gagatcctag gccaattgca 26340 agccatccaa aaagcccgcc aagagttttt gctgaagagg ggtcgggggg tgtatctgga 26400 cccccagtcg ggtgaggagc tcaacccggt tcccccgctg ccaccgccgc gggaccttgc 26460 ttcccaggat aagcatcgcc atggctccca gaaagaagca gcagcggccg ccgctgccgc 26520 cgccccacat gctggaggaa gaggaggaat actgggacag tcaggcagag gaggtttcgg 26580 acgaggagga gccggagacg gagatggaag agtgggagga ggacagctta gacgaggagg 26640 cttccgaagc cgaagaggca ggcgcaacac cgtcaccctc ggccgcagcc ccctcgcagg 26700 cgcccccgaa gtccgctccc agcatcagca gcaacagcag cgctataacc tccgctcctc 26760 caccgccgcg acccacggcc gaccgcagac ccaaccgtag atgggacacc accggaaccg 26820 gggccggtaa gtcctccggg agaggcaagc aagcgcagcg ccaaggctac cgctcgtggc 26880 gcgctcacaa gaacgccata gtcgcttgct tgcaagactg cggggggaac atctccttcg 26940 cccgccgctt cctgctcttc caccacggtg tggccttccc ccgtaacgtc ctgcattact 27000 accgtcatct ctacagcccc tactgcggcg gcagtgagcc agaggcggcc agcggcggcg 27060 gcgcccgttt cggtgcctag gaagacccag ggcaagactt cagccaagaa actcgcggcg 27120 accgcggcga acgcggtcgc gggggccctg cgcctgacgg tgaacgaacc cctgtcgacc 27180 cgcgaactga ggaaccgaat cttccccact ctctatgcca tcttccagca gagcagaggg 27240 caggatcagg aactgaaagt aaaaaacagg tctctgcgct ccctcacccg cagctgtctg 27300 tatcacaaga gcgaagacca gcttcggcgc acgctggagg acgctgaggc actcttcagc 27360 aaatactgcg cgctcactct taaggactag ctccgcgccc ttctcgaatt taggcgggaa 27420 cgcctacgtc atcgcagcgc cgccgtcatg agcaaggaca ttcccacgcc atacatgtgg 27480 agctatcagc cgcagatggg actcgcggcg ggcgcctccc aagactactc cacccgcatg 27540 aactggctca gtgccggccc acacatgatc tcacaggtta atgacatccg cacccatcga 27600 aaccaaatat tggtgaagca ggcggcaatt accaccacgc cccgcaataa tcccaacccc 27660 agggagtggc ccgcgtccct ggtgtatcag gaaattcccg gccccaccac cgtactactt 27720 ccgcgtgatt cccaggccga agtccaaatg actaactcag gggcacagct cgcgggcggc 27780 tgtcgtcaca gggtgcggcc tcctcgccag ggtataactc acctggagat ccgaggcaga 27840 ggtattcagc tcaacgacga gtcggtgagc tcctcgctcg gtctcagacc tgacgggacc 27900 ttccagatag ccggagccgg ccgatcttcc ttcacgcccc gccaggcgta cctgactctg 27960 cagagctcgt cctcggcgcc gcgctcgggc ggcatcggga ctctccagtt cgtgcaggag 28020 tttgtgccct cggtctactt caaccccttc tcgggctctc ccggtcgcta cccggaccag 28080 tttatcccga actttgacgc cgcgagggac tcggtggacg gctacgactg aatgtcgggt 28140 ggacccggtg cagagcaact tcgcctgaag caccttgacc actgccgccg ccctcagtgc 28200 tttgcccgct gtcagaccgg tgagttccag tacttttccc tgcccgactc gcacccggac 28260 ggcccggcgc acggggtgcg ctttttcatc ccgagtcagg tccgctctac cctaatcagg 28320 gagttcaccg cccgtcccct actggcggag ttggaaaagg ggccttctat cctaaccatt 28380 gcctgcattt gctctaaccc tggattacac caagatcttt gctgtcattt gtgtgctgag 28440 tataataaag gctgagatca gaatctactc gggctcctgt cgccatcctg tcaacgccac 28500 cgtccaagcc cggcccgatc agcccgaggt gaacctcacc tgtggtctgc accggcgcct 28560 gaggaaatac ctagcttggt actacaacag cactcccttt gtggtttaca acagctttga 28620 ccaggacggg gtctcactga gggataacct ctcgaacctg agctactcca tcaggaagaa 28680 caacaccctc gagctacttc ctccttacct gcccgggact taccagtgtg tcaccggccc 28740 ctgcacccac acccacctgt tgatcgtaaa cgactctctt ccgagaacag acctcaataa 28800 ctcctctccg cagttcccca gaacaggagg tgagctcagg aaaccccggg taaagaaggg 28860 tggacaagag ttaacacttg tggggtttct ggtatatgtg acgctggtgg tggctctttt 28920 gattaaggct tttccttcca tgtctgaact atccctcttc ttttatgaac aactcgacta 28980 gtgctaacgg gaccctaccc aacgaatcgg gattgaatat cggtaaccag gttgcagttt 29040 cacttttgat taccttcata gtcctcttcc tgctagtgct gtcgcttctg tgcctgcgga 29100 tcgggggctg ctgcatccac gtttatatct ggtgctggct gtttagaagg ttcggagacc 29160 accgcaggta gaataatgct gcttaccctc tttgtcctgg cgctggctgc cagctgccaa 29220 gccttttccg aggctgactt catagagccc cagtgcaata tcacttataa atctgaacgt 29280 gccatctgta ctattctaat caaatgtgtt actcaacacg ataaggtgac tgttaaatac 29340 aaagatcaat taaaaaaaga cgcactttac agcagctggc aaccaggaga tgatcaaaaa 29400 tacaatgtaa ccgtcttcca gggcaaactc tccaaaactt acaattacaa tttcccattt 29460 gagcagatgt gtgactttgt catgtacatg gaaaagcagt acaagctgtg gcctccaact 29520 ccccagggct gtgtggaaaa tccaggctct ttctgtatga tctctctctg tgtaactgtg 29580 ctggcactaa tactcacgct tctgtatctc agatttaaat caaggcaaag cttcattgat 29640 gaaaagaaaa tgccataatc gctcaacgct tgattgctaa caccgggttt ttatccgcag 29700 aatgattgga atcaccctac taatcacctc cctccttgcg attgcccatg ggttggaacg 29760 aatcgaagtc cctgtggggg ccaatgttac cctggtgggg cctgtcggca atgctacatt 29820 aatgtgggaa aaatatacta aaaatcaatg ggtttcttac tgcactaaca aaaacagcca 29880 caagcccaga gccatctgcg atgggcaaaa tctaaccttg attgatgttc aattgctgga 29940 tgcgggctac tattatgggc agctgggtac aatgattaat tactggagac cccacagaga 30000 ttacatgctt cacgtagtaa agggtcccat tagcagccca accaccacct ctaccacacc 30060 cactaccacc actactccca ccaccagcac tgccgcccag cctcctcata gcagaacaac 30120 cacttttatc aattccaagt cccactcccc ccacattgcc ggcgggccct ccgcctcaga 30180 ctccgagacc accgagatct gcttctgcaa atgctctgac gccattgccc aggatttgga 30240 agatcacgag gaagatgagc atgactacgc agatgcatgc caggcatcag aggcagaagc 30300 gctaccggtg gccctaaaac agtatgcaga ctcccacacc acccccaacc ttcctccacc 30360 ttcccagaag ccaagtttcc tgggggaaaa tgaaactctg cctctttcca tactagctct 30420 gacatctgtt gctattttgg ccgctctgct ggtgcttcta tgctctatat gctacctgat 30480 ctgctgcaga aagaaaaaat ctcacggcca tgctcaccag cccctcatgc acttccctta 30540 ccctccagag ctgggcgacc acaaacttta agtctgcagt agctatctgc ccatcccttg 30600 tcagtcgaca gcgatgagcc ccactaatct aacagcctct ggacttacaa cattgtctct 30660 taatgagacc accgctcctc aagacctgta cgatggtgtc tccgcgctgg ttaaccagtg 30720 ggatcacctg ggcatatggt ggctcctcat aggagcagtg accctgtgcc taatcctggt 30780 ctggatcatc tgctgcatca aaagcagaag acccaggcgg cggcccatct acaggccctt 30840 cgtcatcaca cctgaagata atgatgatga tgacaccacc tccaggctgc agagcctaaa 30900 gcagctactc ttctctttta cagcatggta aattgaatca tgccccgcat tttcatctac 30960 ttgcttctcc ttccactttt tctgggctcc tctacattgg ccactgtgtc ccacatcgag 31020 gtagactgcc tcacgccctt cacagtctac ctgcttttcg gctttgtcat ctgcaccttt 31080 gtctgcagcg ttatcactgt agtgatctgc ttcatacagt gcatcgacta catctgtgtg 31140 cgggtggcct actttagaca ccacccccag tatcgcaaca gggacatagc ggctctccta 31200 agacttgttt aaatcatggc caaattacct gtgattggtc ttctgattat ctgctgcgtc 31260 ctagccgcga ttgggactca acctaatacc accaccagcg ctcccagaaa gagacatgta 31320 tcctgcagct tcaagcgtcc ctggaatata ccccaatgct ttactgatga acctgaaatc 31380 tctttggctt ggtacttcag cgtcaccgcc cttctcatct tctgcagtac ggttattgct 31440 cttgccatct acccttccct taacctgggc tggaatgctg tcaactctat ggaatatccc 31500 accttcccag aaccagacct gccagacctg gttgttctaa acgcgtttcc tcctcctcca 31560 gttcaaaatc agtttcgccc tccgtcccct acgcccactg aggtcagcta ctttaatcta 31620 acaggcggag atgactgaaa acctagacct agaaatggac ggtctctgca gcgagcaacg 31680 cacactagag aggcgccggc aaaaagcaga gctcgagcgt cttaaacaag agctccaaga 31740 cgccgtggcc atacaccagt gcaaaaaagg gctcttctgt ctggtaaaac aggccacgct 31800 cacctatgaa aaaacaggtg acacccaccg cctaggatac aagctgccca cacagcgcca 31860 aaagtttgcc cttatgatag gtgaacaacc catcaccgtc acccagcact ccgtggagac 31920 agaaggctgc attcatgctc cctgcagggg cgctgactgc ctctacacct tgatcaaaac 31980 cctctgcggt ctcagagacc ttatcccttt caattgatca taactgtaat caataaaaaa 32040 tcacttactt gaaatctgat agcaagactc tgtccaattt tttcagcaac acttccttcc 32100 cctcctccca actctggtac tctaggcgcc tcctagctgc aaacttcctc cacagtctga 32160 agggaatgtc agattcctcc tcctgtccct ccgcacccac gatcttcatg ttgttacaga 32220 tgaaacgcgc gagatcgtct gacgagacct tcaaccccgt gtacccctac gataccgaga 32280 tcgctccgac ttctgtccct ttccttaccc ctccctttgt atcatccgca ggaatgcaag 32340 aaaatccagc tggggtgctg tccctgcacc tgtcagagcc ccttaccacc cacaatgggg 32400 ccctgactct aaaaatgggg ggcggcctga ccctggacaa ggaagggaat ctcacttccc 32460 aaaacatcac cagtgtcgat ccccctctca aaaaaagcaa gaacaacatc agccttcaga 32520 ccgccgcacc cctcgccgtc agctccgggg ccctaaccct ttttgccact ccccccctag 32580 cggtcagtgg cgacaacctt actgtgcagt ctcaggcccc tcttactttg gaagactcaa 32640 aactaactct ggccaccaaa ggacccctaa ctgtgtccga aggcaaactt gtcctagaaa 32700 cagagcctcc cctgcatgca agtgacagca gtagcctggg ccttagcgtc acggccccac 32760 ttagcattaa caatgacagc ctaggactag acatgcaagc gcccatcagc tctcgagatg 32820 gaaaactggc tctaacagtg gcggcccccc taactgtggc cgagggtatc aatgctttgg 32880 cagtagccac aggtaatggt attggactaa atgaaaccaa cacacacctg caggcaaaac 32940 tggtcgcgcc cctaggcttt gataccaacg gcaacattaa gctaagcgtc gcaggaggca 33000 tgaggctaaa caataacaca ctgatactag atgtaaacta cccatttgag gctcaaggcc 33060 aactgagcct aagagtgggc tcgggcccac tatatgtaga ttctagtagt cataacctaa 33120 ccattagatg ccttagggga ttgtatgtaa catcttctaa caaccaaaac ggtctagagg 33180 ccaacattaa actaacaaaa ggccttgtgt atgacggaaa tgccatagca gttaatgttg 33240 gcaaagggct ggaatacagc cctactggca caacagaaaa acctatacag actaaaatag 33300 gtctaggcat ggagtatgac actgagggag ccatgatgac aaaactaggc tctggactaa 33360 gctttgacaa ttcaggagcc attgtggtgg gaaacaaaaa tgatgacagg cttactttgt 33420 ggaccacacc ggacccatcg cccaactgtc agatttactc tgaaaaagat gctaaactaa 33480 ccttggtact gactaaatgt ggcagtcagg ttgtaggcac agtatctatt gccgctctta 33540 aaggtagcct tgtgccaatc actagtgcaa tcagtgtggt tcagatatac ctaaggtttg 33600 atgaaaatgg ggtgctgatg agtaactctt cacttaatgg cgaatactgg aattttagaa 33660 acggagactc aactaatggc acaccatata caaacgcagt gggttttatg cctaatctac 33720 tggcctatcc taaaggtcaa actacaactg caaaaagtaa cattgtcagc caggtctaca 33780 tgaacgggga cgatactaaa cccatgacat ttacaatcaa cttcaatggc cttagtgaaa 33840 caggggatac ccctgtcagt aaatattcca tgacattctc atggaggtgg ccaaatggaa 33900 gctacatagg gcacaatttt gtaacaaact cctttacttt ctcctacatc gcccaagaat 33960 aaagaaagca cagagatgct tgtttttgat ttcaaaattg tgtgctttta tttattttca 34020 agcttacagt atttccagta gtcattagaa tagagcttaa ttaaactgca tgagaaccct 34080 tccacatagc ttaaattatc accagtgcaa atggaaaaaa atcaacatac ctttttatcc 34140 agatatcaaa gaactctagt ggtcagtttt cccccaccct cccagctcac agaatacaca 34200 gtcctttccc cccggctggc tttaaacaac actatctcat tggtaacaga catattttta 34260 ggtgtaataa tccacacggt ctcttggcgg gccaaacgct ggtctgtgat gttaataaac 34320 tccccaggca gctctttcaa gttcacgtcg ctgtccaact gctgaagcgc tcgcggctcc 34380 gactgcgcct ctagcggagg caacggcagc acccgatcct tgatctataa aggagtagag 34440 tcataatccc ccataagaat agggcggtga tgcagcaaca aggcgcgcag caactcctgc 34500 cgccgcctct ccgtacgaca ggaatgcaac ggggtggtgg tctcctccgc gataatccgc 34560 accgctcgca gcatcagcat cctcgtcctc cgggcacagc agcgcatcct gatctcactg 34620 agatcggcgc agtaagtgca gcacaacacc aagatgttat ttaagatccc acagtgcaaa 34680 gcactgtacc caaagctcat ggcgggaagg acagccccca cgtgaccatc gtaccagatc 34740 ctcaggtaaa tcaaatgacg acctctcata aacacgctgg acatatacat cacctccttg 34800 ggcatgagct gattcaccac ctctcgatac cacaggcatc gctgattaat taaagacccc 34860 tcgagcacca tcctgaacca ggaagccagc acctgacccc ccgccaggca ctgcagggac 34920 cccggtgaat cgcagtggca gtgaagactc cagcgctcgt agccgtgaac catagagctg 34980 gtcattatat ccacattggc acaacacaga cacactttca tacacttttt catgattagc 35040 agctcctctc tagtcaagac catatcccaa ggaatcaccc actcttgaat caaggtaaat 35100 cccacacagc agggcaggcc tctcacataa ctcacgttat gcatagtgag cgtgtcgcaa 35160 tctggaaata ccggatgatc ttccatcacc gaagcccggg tctccgtctc aaagggaggt 35220 aaacggtccc tcgtgtaggg acagtggcgg gataatcgag atcgtgttga acgtagagtc 35280 atgccaaagg gaacagcgga cgtactcata tttcctccag cagaaccaag tgcgcgcgtg 35340 gcagctatcc ctgcgtcttc tgtctcgccg cctgccccgc tcggtgtagt agttgtaata 35400 cagccactcc ctcagaccgt caaggcgctc cctggcgtcc ggatctataa caacaccgtc 35460 ctgcagcgcc gccctgatga catccaccac cgtagagtat gccaagccca gccacgaaat 35520 gcactcactt tgacagcgag agataggagg agcgggaaga gatggaagaa ccatgatagt 35580 aaaagaactt ttattccaat cgatcctcta caatgtcaaa gtgtagatct atcagatggc 35640 actggtctcc tccgctgagt cgatcaaaaa taacagctaa accacaaaca acacgattgg 35700 tcaaatgctg cacaagggct tgcagcataa aatcgcctcg aaagtccacc gcaagcataa 35760 catcaaagcc accgccccta tcatgatcta tgataaaaac cccacagcta tccaccagac 35820 ccatatagtt ttcatctctc catcgtgaaa aaatatttac aagctcctcc tttaaatcac 35880 ctccaaccaa ttcaaaaagt tgagccagac cgccctccac cttcattttc agcatgcgca 35940 tcatgattgc aaaaattcag gctcctcaga cacctgtata agattgagaa gcggaacgtt 36000 aacatcaatg tttcgctcgc gaagatcgcg cctcagtgca agcatgatat aatcccacag 36060 gtcggagcgg atcagcgagg acatctcccc gccaggaacc aactcaacgg agcctatgct 36120 gattataata cgcatattcg gggctatgct aaccagcacg gcccccaaat aggcgtactg 36180 cataggcggc gacaaaaagt gaacagtttg ggttaaaaaa tcaggcaaac actcgcgcaa 36240 aaaagcaaga acatcataac catgctcatg caaatagatg caagtaagct caggaacgac 36300 cacagaaaaa tgcacaattt ttctctcaaa catgactgcg agccctgcaa aaaataaaaa 36360 agaaacatta cacaagagta gcctgtctta caatgggata gactactcta accaacataa 36420 gacgggccac gacatcgccc gcgtggccat aaaaaaaatt atccgtgtga ttaaaaagaa 36480 gcacagatag ctggccagtc atatccggag tcatcacgtg cgaacccgtg tagacccccg 36540 ggttggacac atcggccaaa caaagaaagc ggccaatgta tcccggagga atgataacac 36600 taagacgaag atacaacaga ataaccccat gggggggaat aacaaagtta gtaggtgaat 36660 aaaaacgata aacacccgaa actccctcct gcgtaggcaa aatagcgccc tccccttcca 36720 aaacaacata cagcgcttcc acagcagcca tgacaaaaga ctcaaaacac tcaaaagact 36780 cagtcttacc aggaaaataa aagcactctc acagcaccag cactaatcag agtgtgaaga 36840 gggccaagtg ccgaacgagt atatatagga attaaaaatg acgtaaatgt gtaaaggtca 36900 aaaaacgccc agaaaaatac acagaccaac gcccgaaacg aaaacccgcg aaaaaatacc 36960 cagaagttcc tcaacaaccg ccacttccgc tttcccacga tacgtcactt cctcaaaaat 37020 agcaaactac atttcccaca tgtacaaaac caaaacccct ccccttgtca ccgcccacaa 37080 cttacataat cacaaacgtc aaagcctacg tcacccgccc cgcctcgccc cgcccacctc 37140 attatcatat tggcctcaat ccaaaataag gtatattatt gatgatg 37187 <210> 8 <211> 37175 <212> DNA <213> Great Ape Adenovirus <400> 8 catcatcaat aatatacctt attttggatt gtggccaata tgataatgag gtgggcgggg 60 cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgc ggaagtgtgg catttgcaag 120 tgggaggagc tcacatgtaa gcttccgtcg cggaaaatgt gacgttttta atgagcgccg 180 cctacctccg gaagtgccaa ttttcgcgcg cttttcaccg gatatcgtag taattttggg 240 cgggaccatg taagatttgg ccattttcgc gcgaaaagtg aaacggggaa gtgaaaactg 300 aataataggg cgttagtcat agcgcgtaat atttaccgag ggccgaggga ctttgaccga 360 ttacgtggag gactcgccca ggtgtttttt acgtgaattt ccgcgttccg ggtcaaagtc 420 tccgttttta ttgtcaccgt catctgacgc ggagggtatt taaacccgct gcgctcctaa 480 agaggccact cttgagtgcc agcgagaaga gttttctcct ccgctccgtt tcggcgatcg 540 aaaaatgaga cacttagcct gcactccggg tcttttgtcc ggccgggcgg cgtccgagct 600 tttggacgct ttgctcaatg aggttctgag cgatgatttt ccgtctacta cccactttag 660 cccacctact cttcacgaac tgtacgatct ggatgtactg gtggatgtga acgatcccaa 720 cgaggaggcg gtttctacgt tttttcccga gtctgcgctt ttggccgccc aggagggatt 780 tgacctacac actccgccgc tgcctatttt agagtctccg ctgccggagc ccagtggtat 840 accttatatg cctgaactgc ttcccgaagt ggtagacctg acctgccacg agccgggctt 900 tccgcccagc gacgatgagg gtgagccttt tgctttagac tatgctgaga tacctgggct 960 cggttgcagg tcttgtgcat atcatcagag ggttaccgga gaccccgagg ttaagtgttc 1020 gctgtgctat atgaggctga cctcttcctt tatctacagt aagttttttg tgtaggtggg 1080 ctttttgggt aggtgggttt tgtggcagga caggtgtaaa tgttgcttgt gttttttgta 1140 cctgcaggtc cggtgtccga gccagacccg gagcccgacc gcgatcccga gccggatccc 1200 gagcctcctc gcagggcaag gaaattacct tccattttgt gcaagcctaa gacacctgtg 1260 aggaccagcg aggcggacag cactgactct ggcacttcta cctctcctcc tgaaattcac 1320 ccagtggttc ctttgggtat acataaacct gttgctatta gagtttgcgg gcgacgccct 1380 gcagtagagt gcattgagga cttgcttaac gatcccgagg gacctttgga cttgagcatt 1440 aaacgcccta ggcaataaac cccacctaag taataaaccc cacctaagta ataaacttta 1500 ccgcccttgg ttattgagat gacgcccaat gtttgctttt gaatgacttc atgtgtataa 1560 taaaagtgag tgtggtcata ggtctcttgt ttgtctgggc ggggcttaag ggtatataag 1620 tttctcgggg ctaaacttgg ttacacttga ccccaatgga ggcgtggggg tgcttggagg 1680 agtttgcgga cgtgcgccgt ttgctggacg agagctctag caatacctat agtatttgga 1740 ggtatctgtg gggctctact caggccaagt tggtctccag aattaagcag gattacaagt 1800 gcgattttga agagcttttt agttcctgtg gtgagctttt gcaatccttg aatctgggcc 1860 accaggctat cttccaggaa aaggttctct cgactttgga tttttccact cccgggcgca 1920 ccgccgcttg tgtggctttt gtgtcttttg tgcaagataa atggagcggg gagacccacc 1980 tgagtcacgg ctacgtgctg gatttcatgg cgatggctct ttggagggct tacaacaaat 2040 ggaagattca gaaggaactg tacggttccg ccctacgtcg tccacttctg cagcggcagg 2100 ggctgatgtt tcccgaccat cgccagcatc agaatctgga agacgagtcg gaggagcgag 2160 cggagaagat cagcttgaga gccggcctgg accctcctca ggaggaatga atctcccgca 2220 ggtggttgac ctgtttcccg aactgagacg ggtcctgact atcagggaag atggtcagtt 2280 tgtgaagaag ctgaagaggg atcggggtga gggagatgat gaggcggcta gcaatttagc 2340 ttttagtctg ataacccgcc accgaccgga atgtattacc tatcagcaga ttaaggagag 2400 ttgtgccaac gagctggatc ttttgggtca gaagtatagc atagaacagc ttaccactta 2460 ctggcttcag cccggggatg attgggaaga ggcgatcagg gtgtatgcaa aggtggccct 2520 gcggcccgat tgcaagtata agattactaa gttggttaat attagaaact gctgctatat 2580 ttctgggaac ggggccgaag tggagataga tactgaggac agggtggcta ttaggtgttg 2640 catgataaac atgtggcccg ggatactggg gatggatggg gtgatattta tgaatgtaag 2700 gttcacgggc cccaacttta atggtacggt gttcatgggc aacaccaact tgctcctgca 2760 tggtgcgagt ttctatgggt ttaacaacac ctgtatagag gcctggaccg atgtaaaggt 2820 tcgaggttgt tccttttata gctgttggaa ggcggtggtg tgtcgcccta aaagcagggg 2880 ttctgtgaag aaatgcttgt ttgaaaggtg caccctaggt atcctttctg agggcaactc 2940 cagggtgcgc cataatgtgg cttcgaactg cggttgcttc atgcaagtga agggggtgag 3000 cgttatcaag cataactcgg tctgtggaaa ctgcgaggat cgcgcctctc agatgctgac 3060 ctgctttgat ggcaactgtc acctgttgaa gaccattcat ataagcagtc accccagaaa 3120 ggcctggccc gtgtttgagc ataacattct gacccgctgt tccttgcatc tgggggtcag 3180 gaggggtatg ttcctgcctt accagtgtaa cttcagccac actaaaatcc tgctggaacc 3240 cgagtgcatg actaaggtca gcctgaatgg tgtgtttgat gtgagtctga agatttggaa 3300 ggtgctgagg tatgatgaga ccaggaccag gtgccgaccc tgcgagtgcg gcggcaagca 3360 catgagaaat cagcctgtga tgttggatgt gaccgaggag cttaggcctg accatctggt 3420 gctggcctgc accagggccg agtttgggtc tagcgatgag gataccgatt gaggtgggta 3480 aggtgggcgt ggctagcagg gtgggcgtgt ataaattggg ggtctaaggg gtctctctgt 3540 ttgtcttgca acagccgccg ccatgagcga caccggcaac agctttgatg gaagcatctt 3600 tagcccctat ctgacagtgc gcatgcctca ctgggccgga gtgcgtcaga atgtgatggg 3660 ttccaacgtg gatggacgtc ccgttctgcc ttcaaattcg tctacgatgg cctacgcgac 3720 cgtgggagga actccgttgg acgccgcgac ctccgccgcc gcctccgccg ccgccgcgac 3780 cgcgcgcagc atggctacgg acctttacag ctctttggtg gcgagcagcg cggcctctcg 3840 cgcgtctgct cgggatgaga aactgactgc tctgctgctt aaactggaag acttgacccg 3900 ggagctgggt caactgaccc agcaggtctc cagcttgcgt gagagcagcc ttgcctcccc 3960 ctaatggccc ataatataaa taaaagccag tctgtttgga ttaagcaagt gtatgttctt 4020 tatttaactc tccgcgcgcg gtaagcccgg gaccagcggt ctcggtcgtt tagggtgcgg 4080 tggattcttt ccaacacgtg gtacaggtgg ctctggatgt ttagatacat gggcatgagt 4140 ccatccctgg ggtggaggta gcaccactgc agagcttcgt gctcgggggt ggtgttgtat 4200 atgatccagt cgtagcagga gcgctgggcg tggtgctgaa aaatgtcctt aagcaagagg 4260 cttatagcta gggggaggcc cttggtgtaa gtgtttacaa atctgctcag ctgggagggg 4320 tgcatccggg gggatatgat gtgcatcttg gactggattt ttaggttggc tatgttccca 4380 cccagatccc ttctgggatt catgttgtgc aggaccacca gcacggtata tccagtgcac 4440 ttgggaaatt tatcgtggag cttagacggg aatgcatgga agaacttgga gacgcccttg 4500 tggcctccca gattttccat acattcgtcc atgatgatgg caatgggccc gtgggaagct 4560 gcctgagcaa aaacgtttct gggatcgctc acatcgtagt tatgttccag ggtgaggtca 4620 tcataggaca tctttacgaa tcgggggcgg agggtcccgg actgggggat gatggtaccc 4680 tcgggccccg gggcgtagtt cccctcacag atctgcatct cccaggcttt catttcagag 4740 ggagggatca tatccacctg cggggcgatg aaaaagacag tttctggcgc aggggagatt 4800 aactgggatg agagcaggtt tctgagcagc tgtgactttc cacagccggt gggcccatat 4860 atcacgccta tcaccggctg cagctggtag ttaagagagc tgcagctgcc gtcctcccgg 4920 agcagggggg ccacctcgtt gagcatatcc ctgacgtgga tgttttccct gaccagttcc 4980 gccagaaggc gctcgccgcc cagcgaaagc agctcttgca aggaagcaaa atttttcagc 5040 ggtttcaggc catcggccgt gggcatgttt ttcagcgtct gggtcagcag ctccagcctg 5100 tcccagagct cggtgatgtg ctctacggca tctcgatcca gcagatctcc tcgtttcgcg 5160 ggttggggcg gctttcgctg tagggcacca gccgatgggc gtccagcggg gccagagtca 5220 tgtccttcca tgggcgcaga gtcctcgtca gggtggtctg ggtcacggtg aaggggtgcg 5280 ctccgggttg ggcgctggcc agggtgcgct tgaggctggt tctgctggtg ctgaatcgct 5340 gccgctcttc gccctgcgcg tcggccaggt agcatttgac catggtctcg tagtcgagac 5400 cctcggcggc gtgccccttg gcgcggagct ttcccttgga ggtggcgccg cacgaggggc 5460 actgcaggct cttcagggcg tagagcttgg gagcgagaaa cacggactct ggggagtagg 5520 cgtccgcgcc gcaggccgag cagaccgtct cgcattccac cagccaagtg agttccgggc 5580 ggtcagggtc aaaaaccagg ctgcccccat gctttttgat gcgtttctta cctcggctct 5640 ccatgaggcg gtgtcccttc tcggtgacga agaggctgtc cgtgtccccg tagaccgatt 5700 tcaggggcct gtcttccagc ggagtgcctc tgtcctcctc gtagagaaac tctgaccact 5760 ctgagacaaa ggcccgtgtc caggccagga cgaaggaggc cacgtgggag gggtagcggt 5820 cgttgtccac tagcgggtcc accttctcca gggtgtgcag gcacatgtcc ccctcctccg 5880 cgtccagaaa agtgattggc ttgtaggtgt aggacacgtg accgggggtt cccgacgggg 5940 gggtataaaa gggggtgggt gccctttcat cttcactctc ttccgcatcg ctgtctgcga 6000 gagccagctg ctggggtaag tattcccttt cgaaggcggg catgacctca gcgctcaggt 6060 tgtcagtttc taaaaatgag gaagatttga tgttcacctg tccggaggtg atacctttga 6120 gggtacctgg gtctatctgg tcagaaaaca ctattttttt gttatcaagc ttggtggcga 6180 acgacccgta gagggcgttg gagagcagct tggcgatgga gcgcagggtc tggtttttgt 6240 cgcggtcggc tcgctccttg gccgcgatgt tgagttgcac gtactcgcgg gccacgcact 6300 tccactcggg gaagacggtg gtgcgctcgt ctgggatcag gcgcaccctc cagccgcggt 6360 tgtgcagggt gaccatgtcg acgctggtgg cgacctcacc gcgcaggcgc tcgttggtcc 6420 agcagaggcg gccgcccttg cgcgagcaga aggggggtag ggggtccagc tggtcctcgt 6480 tcggggggtc cgcgtcgatg gtaaagaccc cggggagcag acgcgggtca aagtagtcga 6540 tcttgcaagc ttgcatgtcc agagcccgct gccattcgcg ggcggcgagc gcgcgctcgt 6600 aggggttgag gggcgggccc cagggcatgg ggtgggtgag cgcagaggcg tacatgccgc 6660 agatgtcata cacgtacagg ggttccctga ggatgccgag gtaggtgggg tagcagcgcc 6720 ccccgcggat gctggcgcgc acgtagtcat agagttcgtg ggagggggcc agcatgttgg 6780 gcccgaggtt ggtgcgctgg gggcgctcgg cgcggaagac gatctgcctg aagatggcgt 6840 gggagttgga ggagatggtg ggccgctgga agacgttgaa gcttgcttct tgcaagccca 6900 cggagtccct gacgaaggag gcgtaggact cgcgcagctt gtgcaccagc tcggcggtga 6960 cctggacgtc gagcgcacag tagtcgaggg tctcacggat gatgtcatac ttatcctccc 7020 ccttcttttt ccacagctcg cggttgagga cgaactcttc gcggtctttc cagtactctt 7080 ggaggggaaa cccgtccgtg tccgaacggt aagagcctag catgtagaac tggttgacgg 7140 cctggtaggg gcagcagccc ttctccacgg gcagcgcgta ggcctgcgcc gccttgcgga 7200 gggaggtgtg ggtgagggcg aaagtgtccc tgaccatgac tttgaggtat tgatgtctga 7260 agtctgtgtc atcgcagccg ccctgttccc acagggtgta gtccgtgcgc tttttggagc 7320 gcgggttggg cagggagaag gtgaggtcat tgaagaggat cttccccgct cgaggcatga 7380 agtttctggt gatgcgaaag ggccctggga ccgaggagcg gttgttgatg acctgggcgg 7440 ccaggacgat ctcgtcaaag ccgtttatgt tgtggcccac gatgtagagc tccaggaagc 7500 ggggctggcc cttgatggag gggagctttt taagttcctc gtaggtgagc tcctcgggcg 7560 attccaggcc gtgctcctcc agggcccagt cttgcaagtg agggttggcc gccaggaagg 7620 atcgccagag gtcgcgggcc atgagggtct gcaggcggtc gcggaaggtt ctgaactgtc 7680 gccccacggc catcttttcg ggggtgatgc aatagaaggt gagggggtct ttctcccagg 7740 ggtcccatct gagctctcgg gcgaggtcgc gtgcggcggc gaccagagcc tcgtcgcccc 7800 ccagtttcat gaccagcatg aagggcacga gctgcttgcc aaaggctccc atccaagtgt 7860 aggtctctac atcgtaggtg acaaagaggc gctccgtgcg aggatgagag ccgatcggga 7920 agaactggat ctcccgccac cagttggagg attggctgtt gatgtggtga aagtagaagt 7980 cccgtctgcg ggccgagcac tcgtgctggc ttttgtaaaa gcgaccgcag tactggcagc 8040 gctgcacggg ttgtatatct tgcacgaggt gaacctggcg acctctgacg aggaagcgca 8100 gcgggaatct aagtcccccg cctggggtcc cgtgtggctg gtggtcttct actttggttg 8160 tctggccgcc agcatctgtc tcctggaggg cgatggtgga acagaccacc acgccgcgag 8220 agccgcaggt ccagatctcg gcgctcggcg ggcggagttt gatgacgaca tcgcgcacat 8280 tggagctgtc catggtctcc agctcccgcg gcggcaggtc agccgggagt tcctggaggt 8340 ttacctcgca gagacgggtc aacgcacggg cagtgttaag atggtatctg atttcaaggg 8400 gcgtgttggc ggcggagtcg atggcttgca ggaggccgca gccccggggg gccacgatgg 8460 ttccccgtgg ggcgcgaggg gaggcggaag ctgggggtgt gttcagaagc ggtgacgcgg 8520 gcgggccccc ggaggtaggg ggggttccgg ccccacaggc atgggcggca ggggcacgtc 8580 ttcgccgcgc gcgggcaggg gctggtgctg gctccgaaga gcgcttgcgt gcgcgacgac 8640 gcgacggttg gtgtcctgta tctggcgcct ctgagtgaag accacgggtc ccgtgacctt 8700 gaacctgaaa gagagttcga cagaatcaat ctcggcatcg ttgacagcgg cctggcgcag 8760 gatctcctgc acgtcgcccg agttgtcctg gtaggcgatc tctgccatga actgctcgat 8820 ctcttcctcc tggagatctc ctcgtccggc gcgctccacg gtggccgcca ggtcgttgga 8880 gatgcgaccc atgagctgcg agaaggcgtt gagtccgccc tcgttccaga cccggctgta 8940 gaccacgccc ccctcggcgt cgcgggcgcg catgaccacc tgggccaggt tgagctccac 9000 gtgtcgcgtg aagacggcgt agttgcgcag gcgctggaaa aggtagttca gggtggtggc 9060 ggtgtgctcg gcgacaaaga agtacatgac ccagcgccgc aacgtggatt cattgatgtc 9120 ccccaaggcc tccaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 9180 ggagttgcga gcggacacgg tcaactcctc ctccagaaga cggatgagct cggcgacagt 9240 gtcgcgcacc tcgcgctcga aggccacggg gggcgcttct tcctcttcca cctcttcttc 9300 catgattgct tcttcttctt cctcagccgg gacgggaggg ggcggcggcg ggggaggggc 9360 gcggcggcgg cggcggcgca ccgggaggcg gtcgatgaag cgctcgatca tctccccccg 9420 catgcggcgc atggtctcgg tgacggcgcg gccgttctcc cgggggcgca gctcgaagac 9480 gccgcctttc atctcgccgc ggggcgggcg gccgtgaggt agcgagacgg cgctgactat 9540 gcatcttaac aattgctgtg taggtacgcc gccaagggac ctgattgagt ccagatccac 9600 cggatccgaa aacctttgga ggaaagcgtc tatccagtcg cagtcgcaag gtaggctgag 9660 caccgtggcg ggcgggggcg ggtcgggaga gttcctggcg gagatgctgc tgatgatgta 9720 attaaagtag gcggtcttga gaaggcggat ggtggacagg agcaccatgt ctttgggtcc 9780 ggcctgttgg atgcggaggc ggtcggccat gccccaggcc tcgttctgac accggcgcag 9840 gtctttgtag tagtcttgca tgagtctttc caccggcacc tcttctcctt cctcttctcc 9900 atctcgccgg tggtttctcg cgccgcccat gcgcgtgacc ccaaagcccc tgagcggctg 9960 cagcagggcc aggtcggcga ccacgcgctc ggccaagatg gcctgctgta cctgagtgag 10020 ggtcctctcg aagtcatcca tgtccacgaa gcggtggtag gcgcccgtgt tgatggtgta 10080 ggtgcagttg gccatgacgg accagttgac ggtctggtgt cccggctgcg agagctccgt 10140 gtaccgcagg cgcgagaagg cgcgggaatc gaacacgtag tcgttgcaag tccgcaccag 10200 atactggtag cccaccagga agtgcggcgg aggttggcga tagaggggcc agcgctgggt 10260 ggcgggggcg ccgggcgcca ggtcttccag catgaggcgg tggtatccgt agatgtacct 10320 ggacatccag gtgatgccgg cggcggtggt ggtggcgcgc gcgtagtcgc ggacccggtt 10380 ccagatgttt cgcaggggcg agaagtgttc catggtcggc acgctctggc cggtgaggcg 10440 cgcgcagtcg ttgacgctct atacacacac aaaaacgaaa gcgtttacag ggctttcgtt 10500 ctgtagcctg gaggaaagta aatgggttgg gttgcggtgt gccccggttc gagaccaagc 10560 tgagctcggc cggctgaagc cgcagctaac gtggtattgg cagtcccgtc tcgacccagg 10620 ccctgtatcc tccaggatac ggtcgagagc ccttttgctt tcttggccaa gcgcccgtgg 10680 cgcgatctgg gatagatggt cgcgatgaga ggacaaaagc ggctcgcttc cgtagtctgg 10740 agaaacaatc gccagggttg cgttgcggcg taccccggtt cgagccccta tggcggcttg 10800 gatcggccgg aaccgcggct aacgtgggct gtggcagccc cgtcctcagg accccgccag 10860 ccgacttctc cagttacggg agcgagcccc ttttgttttt tattttttag atgcatcccg 10920 tgctgcggca gatgcgcccc tcgccccggc ccgatcagca gcagcaacag caggcatgca 10980 gacccccctc tcctctcccc gccccggtca ccacggccgc ggcggccgtg tccggcgcgg 11040 ggggtgcgct ggagtcagat gagccaccgc ggcggcgacc taggcagtat ctggacttgg 11100 aagagggcga gggactggcg cggctggggg cgagctcccc agagcgtcac ccgcgggtgc 11160 agttgaaaag ggacgcgcgc gaggcgtacc tgccgcggca aaacctgttt cgcgaccgcg 11220 ggggcgagga gcccgaggag atgcgagact gcaggttcca agcagggcgc gagctgcgcc 11280 gcggcttgga cagagagcgc ttgctgcgcg aggaggactt tgagcccgac acgcagacgg 11340 gcatcagccc cgcgcgcgcg cacgtggccg cggccgacct ggtgaccgcc tacgagcaga 11400 cggtgaacca ggagcgcaac ttccaaaaaa gcttcaacaa ccacgtgcgc acgctggtgg 11460 cgcgcgagga ggtgaccctg ggtctcatgc atctgtggga cctggtggag gcgatcgtgc 11520 agaaccccag cagcaagccc ctgaccgcgc agctgttcct ggtggtgcag cacagcaggg 11580 acaacgatgc cttcagggag gcgctgctga acatcaccga gccggagggg cgctggctcc 11640 tggacctgat aaacatcctg cagagcatag tggtgcagga gcgcagcctg agcctggccg 11700 agaaggtggc ggccattaac tattctatgc tgagcctggg caagttctac gcccgcaaga 11760 tctacaagac cccctacgtg cccatagaca aggaggtgaa gatagacagc ttctacatgc 11820 gcatggcgct aaaggtgctg accctgagcg acgacctggg agtgtaccgc aacgagcgca 11880 tccacaaggc cgtgagcgcc agccggcggc gcgagctgag cgaccgcgag ctgatgcaca 11940 gtctgcaacg cgcgctgacc ggcgcgggcg agggcgacag ggaggtcgag tcctacttcg 12000 acatgggggc cgacctgcac tggcagccga gccgccgcgc cctggaggcg gcgggggcgt 12060 atggcggccc cctggcggcc gatggcgagg aagaggagga ctatgagcta gaggagggcg 12120 agtacctgga ggactgacct ggctggtggt gttttggtat agatgcaaga tccgaacgtg 12180 gcggacccgg cggtccgggc ggcgctgcag agccagccgt ccggcattaa ctcctctgac 12240 gactgggccg cggccatggg tcgcatcatg gccctgaccg cgcgcaaccc cgaggccttc 12300 aggcagcagc ctcaggctaa ccggctggcg gccatcttgg aagcggtagt gcccgcgcgc 12360 tccaacccca cccacgagaa ggtgctggcc atagtcaacg cgctggcgga gagcagggcc 12420 atccgggcgg acgaggccgg actggtgtac gatgcgctgc tgcagcgggt ggcgcggtac 12480 aacagcggca acgtgcaaac caacctggac cgcctggtga cggacgtgcg cgaggccgtg 12540 gcgcagcgcg agcgcttgca tcaggacggt aacctgggct cgctggtggc gctaaacgcc 12600 ttcctcagca cccagccggc caacgtaccg cgggggcagg aggactacac caacttcttg 12660 agcgcgctgc ggctgatggt gaccgaggtc cctcagagcg aagtgtacca gtcggggccc 12720 gactacttct tccagaccag cagacagggc ttgcaaaccg tgaacctgag ccaggctttc 12780 aagaacctgc gggggctgtg gggagtgaag gcgcccaccg gcgaccgggc tacggtgtcc 12840 agcctgctaa cccccaactc gcgcctgctg ctgctgctga tcgcgccctt cacggacagc 12900 gggagcgtct cgcgggagac ctatctgggc cacctgctga cgctgtaccg cgaggccatc 12960 gggcaggcgc aggtggacga gcacaccttc caggagatca ccagcgtgag ccacgcgctg 13020 gggcaggagg acacgggcag cctgcaggcg accctgaact acctgctgac caacaggcgg 13080 cagaagattc ccacgctgca cagcctgacc caggaggagg agcgcatctt gcgctacgtg 13140 cagcagagcg tgagcctgaa cctgatgcgc gacggcgtga cgcccagcgt ggcgctggac 13200 atgaccgcgc gcaacatgga accgggcatg tacgcttccc agcggccgtt catcaaccgc 13260 ctgatggact acttgcatcg ggcggcggcc gtgaaccccg agtacttcac caatgccatt 13320 ctgaatcccc actggatgcc ccctccgggt ttctacaacg gggactttga ggtgcccgag 13380 gtcaacgacg ggttcctctg ggatgacatg gatgacagtg tgttctcccc caacccgctg 13440 cgcgccgcgt ctctgcgatt gaaggagggc tctgacaggg aaggaccgag gagtttggcc 13500 tcctccctgg ctctgggggc ggtgggcgcc acgggcgcgg cggcgcgggg cagcagcccc 13560 ttccccagcc tggcggactc tctgaatagc gggcgggtga gcaggccccg cttgctaggc 13620 gaggaggagt atctgaacaa ctccctgcta cagcccgtga gggacaaaaa cgctcagcgg 13680 cagcagtttc ccaacaacgg gatagagagc ctggtggaca agatgtccag atggaagacg 13740 tatgcgcagg agtacaagga gtgggaggac cgacagccgc ggcccctgcc gccccctaga 13800 cagcgctggc agcggcgtgc gtccaaccgc cgctggaggc aggggcccga ggacgatgat 13860 gactctgcag atgacagcag cgtgttggat ctgggcggga gcgggaaccc cttttcgcac 13920 ctgcgcccac gcctgggcaa gatgttttaa aagagaaaaa taaaaactca ccaaggccat 13980 ggcgacgagc gttggttttt ttgttccctt ccttagtatg cggcgcgcgg cgatgttcga 14040 ggaggggcct cccccctctt acgagagcgc gatgggaatt tctcctgcgg cgcccctgca 14100 gcctccctac gtgcctcctc ggtacctgca acctacaggg gggagaaata gcatctgtta 14160 ctctgagctg cagcccctgt acgataccac cagactgtac ctggtggaca acaagtccgc 14220 ggacgtggcc tccctgaact accagaacga ccacagcgat tttttgacca cggtgatcca 14280 aaacaacgac ttcaccccaa ccgaggccag tacccagacc ataaacctgg acaacaggtc 14340 gaactggggc ggcgacctga agactatcct gcacaccaat atgcccaacg tgaacgagtt 14400 catgttcacc aactctttta aggcgcgggt gatggtggcg cgcgagcagg gggaggcgaa 14460 gtacgagtgg gtggacttca cgctgcccga gggcaactat tcagagacca tgactctcga 14520 cctgatgaac aatgcgatcg tggaacacta tctgaaagtg ggcaggcaga acggggtgaa 14580 ggagagcgat atcggggtca agtttgacac cagaaacttt cgtctgggct gggaccccgt 14640 gaccgggctg gtcatgccgg gggtctacac caacgaggcc tttcatcccg atatagtgct 14700 cctgcccggc tgtggggtgg actttaccca gagccggctg agcaacctgc tgggcgttcg 14760 caagcggcaa cctttccagg agggtttcaa gatcacctat gaggatctgg aggggggcaa 14820 cattcccgcg ctccttgatc tggacgccta cgaggagagc ttgaaacccg aggagagcgc 14880 tggcgacagc ggcgagagtg gcgaggagca agccggcggc ggtggcagcg cgtcggtaga 14940 aaacgaaagt actcccgcag tggcggcgga cgctgcggag gtcgagccgg aggccatgca 15000 gcaggacgca gaggagggcg cgcaggagga catgaacaat ggggagatca ggggcgacac 15060 tttcgccacc cggggcgaag aaaaagaggc agaggcggcg gcggcgacgg cggaagccga 15120 aaccgaggca gaggcagagc ccgagaccga agttatggaa gacatgaatg atggagaacg 15180 taggggtgac acgtttgcca cccggggcga agagaaggcg gcggaggcag aagccgcggc 15240 tgaggaggcg gctgcggctg cggccaaggc tgaggctgcg gctgaggcta aggtcgaagc 15300 cgatgttgcg gttgaggctc aggctgagga ggaggcggcg actgaagcag ttaaggaaaa 15360 ggcccaggca gagcaggaag agaaaaaacc tgtcattcaa cctctaaaag aagatagcaa 15420 aaagcgcagt tacaacgtca tcgagggcag cacctttacc caataccgca gctggtacct 15480 ggcttacaac tacggcgacc cggtcaaggg ggtgcgctcg tggaccctgc tctgcacgcc 15540 ggacgtcacc tgcggctccg agcagatgta ctggtcgctg ccaaacatga tgcaagaccc 15600 ggtgaccttc cgttccacgc ggcaggttag caactttccg gtggtgggcg ccgaactgct 15660 gccagtgcac tccaagagtt tttacaacga gcaggccgtc tactcccagc tgatccgcca 15720 ggccacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc 15780 gccggccccc accatcacca ccgtcagtga aaacgttcct gccctcacag atcacgggac 15840 gctaccgctg cgcaacagca tctcaggagt ccagcgagtg accattactg acgccagacg 15900 ccggacctgc ccctacgttt acaaggcctt gggcatagtc tcgccgcgcg tcctctccag 15960 tcgcactttt taaaacacat ctaccctcac gctccaaaat catgtccgta ctcatctcgc 16020 ccagcaacaa caccggctgg gggctgcgcg cgcccagcaa gatgtttgga ggggcgagga 16080 aacgctccga acagcaccca gtgcgcgtgc gcggccacta ccgcgcgccc tggggtgcgc 16140 acaagcgcgg gcgcacaggg cgcaccactg tggatgatgt cattgactcc gtagtggagc 16200 aggcgcgcca ctacacaccc ggcgcgccga ccgcctccgc cgtgtccacc gtggaccagg 16260 cgatcgaaag cgtggtacag ggggcgcggc actatgccaa ccttaaaagt cgccgccgcc 16320 gcgtggcgcg ccgccatcgc cggagacccc gggctactgc cgccgcgcgc cttaccaagg 16380 ctctgctcaa gcgcgccagg cgaactggcc accgggccgc catgagggcc gcacggcggg 16440 ctgccgctgc cgcgagcgcc gtggccccgc gggcacgaag gcgcgcggcc gctgccgccg 16500 ccgccgccat ttccagcttg gcctcgacgc ggcgcggtaa catatactgg gtgcgcgact 16560 cggtaagcgg cacacgggtg cccgtgcgct ttcgcccccc acggaattag cacaaaacaa 16620 catacacact gagtctcctg ctgttgtgta tcccagcggc gaccgtcagc agcggcgaca 16680 tgtccaagcg caaaattaaa gaagagatgc tccaggtcat cgcgccggag atctatgggc 16740 ccccgaagaa ggaggaggat gattacaagc cccgcaagct aaagcgggtc aaaaagaaaa 16800 agaaagatga tgacgttgac gaggcggtgg agtttgtccg ccgcatggcg cccaggcgcc 16860 ccgtgcagtg gaagggtcgg cgcgtgcagc gagtcctgcg ccccggcacc gcggtggtct 16920 ttacgcccgg cgagcgttcc acgcgcactt tcaagcgggt gtacgatgag gtgtacggcg 16980 acgaggatct gttggagcag gccaaccatc gctttgggga gtttgcatat gggaaacggc 17040 cccgcgagag cctaaaagag gacctgctgg cgctaccgct ggacgagggc aatcccaccc 17100 cgagtctgaa gccggtaacc ctgcaacagg tgctgccttt gagcgcgccc agcgagcaga 17160 agcgagggtt gaagcgcgag ggcggggacc tggcacccac cgtgcagttg atggtgccca 17220 agcggcagaa gctggaggac gtgctggaga aaatgaaagt agagcccggg atccagcccg 17280 aaatcaaggt ccgccccatc aagcaggtgg cgcccggcgt gggagtccag accgtggacg 17340 ttaggattcc cacggaggag atggaaaccc aaaccgccac tccctcttcg gcggctagcg 17400 ccaccaccgg cgccgcttcg gtagaggtgc agacggaccc ctggctacct gccgccactg 17460 tcgccgccgc cgccgccgcc ccccgttcgc gcgggcgcaa gagaaattat ccagcggcca 17520 gcgcgctcat gccccagtac gcactgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcacccgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcattg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg cctccgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcagag gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgctg 17940 cccttcctaa tcccgctaat cgccgcggcg atcggtgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc attttttgga 18060 ggaaaaaata aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagt ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggccaga tgctgagaga caagttgaaa gagcagaact tccaggaaaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccggcctcag gtggaggaaa cgcctccagc 18480 aatggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcctaccact cgccccatag cccccatggc caccggtgtg gtgggacaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgatccgcct cgccagccaa aggcggcgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgccc ctgcgccgcg ctgcaagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gtttatcccc gtggatcggg 19200 aggacaccgc ctactcttac aaggcgcggt ttacgctggc cgtgggcgac aatcgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaact caggcggccg aggaagctgt tgacgaggaa gatgcagaag 19440 atgaagcgca accacaagag gaagcccctg ttaaaaaaat tcatgtatat gctcaggcgc 19500 ctcttgctgg cgaaaagatt accaaggatg gtttgcaaat aggtactgaa gtcgtaggag 19560 atacatctaa ggacactttt gcagataaaa cattccaacc cgaacctcag ataggcgagt 19620 ctcagtggaa cgaggctgat gccgcagtag caggaggtag agttttgaaa aagactaccc 19680 ctatgagacc ttgctatgga tcctatgcca ggcctaccaa tgccaacggg ggtcaaggaa 19740 ttatggttgc caatgaaaaa ggagtgttgc agtctaaagt agaaatgcaa tttttctcta 19800 acacctcaac ccttaatgcg cgggatggaa ccggcaatcc cgaaccaaag gtggtgttgt 19860 acagcgaaga tgtccacttg gaatctcccg atactcatct gtcttacaag cccacaaagg 19920 atgatgttaa tgccaaagtc atgttgggtc agcaagccat gcccaacaga cccaacctca 19980 ttggatttag agataatttc attgggctta tgttttacaa cagcaccggt aacatgggag 20040 tgctggcggg tcaggcctct cagttgaatg ctgtggtgga cttgcaggat agaaacacag 20100 aactgtcata tcagcttatg cttgattcaa ttggggatag aaccagatac ttctccatgt 20160 ggaaccaggc agtggatagc tatgatccag atgtcagaat tattgaaaac catggggttg 20220 aggatgaact gcccaactac tgcttccctt tgggcggcat aggaattact gatacttatc 20280 aaggggtgaa aaataccaat ggcaatggtc agtggaccaa agatgatcag ttcgcggacc 20340 gcaacgaaat aggggtggga aacaacttcg ccatggagat caacatccag gccaaccttt 20400 ggagaaactt cctctatgca aacgtggggc tctacctgcc agacaagctc aagtacaacc 20460 ccaccaacgt ggacatctct gacaacccca acacctatga ctacatgaac aagcgggtgg 20520 tggcccctgg cctggtggac tgctttgtca atgtgggagc caggtggtcc ctggactaca 20580 tggacaacgt caaccccttc aaccaccacc gcaatgcggg tctgcgctac cgctccatga 20640 tcctgggcaa cgggcgctat gtgccctttc acatccaggt accccagaag ttctttgcca 20700 tcaagaacct cctgctcctg cccggctcct acacctacga gtggaacttc aggaaggatg 20760 tgaacatggt cctacagagc tctctgggca atgaccttag ggtggatggg gccagcatca 20820 agtttgacag catcaccctc tatgctacat ttttccccat ggcccacaac accgcctcca 20880 cgcttgaggc catgctgaga aacgacacca acgaccagtc ctttaatgac tacctctctg 20940 gggccaacat gctctaccca atcccagcca aggccaccaa cgtgcccatc tccatcccct 21000 ctcgcaactg ggccgccttt agaggctggg cctttacccg ccttaagacc aaggagaccc 21060 cctccctggg ctcgggtttt gatccctact ttgtttactc gggatccatc ccctacctgg 21120 atggcacctt ctacctcaac cacactttca agaagatatc catcatgtat gactcctccg 21180 tcagctggcc gggcaacgac cgcttgctca cccccaatga gttcgaggtc aagcgcgccg 21240 tggacggcga gggctacaac gtggcccagt gcaacatgac caaggactgg ttcctggtgc 21300 agatgctggc caactacaac ataggctacc agggctttta catcccagag agctacaagg 21360 acaggatgta ctccttcttc agaaatttcc aacccatgag ccgacaggtg gtggacgaga 21420 ccaattacaa ggactatcaa gccattggca tcacccacca gcacaacaac tcgggtttcg 21480 tgggctacct ggcgcccacc atgcgcgagg gtcaggccta ccccgccaac ttcccctacc 21540 ccttgatagg caagaccgcg gtcgacagcg tcacccagaa aaagttcctc tgcgaccgca 21600 ccctctggcg catccccttc tctagcaact tcatgtccat gggtgcgctc acggacctgg 21660 gccaaaacct gctttatgcc aactctgccc atgcgctgga catgactttc gaggtggacc 21720 ccatggacga gcccaccctt ctctatattg tgtttgaagt gttcgacgtg gtcagagtgc 21780 accagccgca ccgcggtgtc atcgagaccg tgtacctgcg tacgcccttc tcagccggca 21840 acgccaccac ctaaggagac agcgccgccg cctgcatgac tggttccacc gagcaagagc 21900 tcagggccat cgccagagac ctgggatgcg gaccctactt tttgggcacc tatgacaaac 21960 gcttcccggg tttcatctcc cgagacaagc tcgcctgcgc catcgtcaac acggccgcgc 22020 gcgagaccgg gggcgtgcac tggctggcct ttggctggga cccgcgctct aaaacttgct 22080 acctctttga cccctttggc ttctctgatc agcgcctcag gcagatttat gagtttgagt 22140 acgaggggct gctgcgccgc agcgcgcttg cctcctcgcc cgaccgctgc atcacccttg 22200 agaagtccac cgagaccgtg caggggcccc actcggccgc ctgcggtctc ttctgttgca 22260 tgtttttgca cgcctttgta cactggcctc agagtcccat ggatcgcaac cccaccatga 22320 acttgctaaa gggagtgccc aacgccatgc tccagagccc ccaggtcctg cccaccctgc 22380 gccgcaacca ggaacagctc taccgcttcc tggagcgcca ctccccctac ttccgcagcc 22440 acagcgcgcg catccggggg gccacctctt tttgccactt gcaagaaaac atgcaagacg 22500 gaaaatgatg tacagcatgc ttttaataaa tgtaaagact gtgcacttta tttatacacg 22560 ggctctttct ggttatttat tcaacaccgc cgtcgccatc tagaaatcga aagggttctg 22620 ccgcgcgtcg ccgtgcgcca cgggcagaga cacgttgcga tactggaagc ggctcgccca 22680 cttgaactcg ggcaccacca tgcggggcag tggttcctcg gggaaattct cgctccacag 22740 ggtgcgggtc agctgcagcg cgctcaggag gtcgggagcc gagatcttga agtcgcagtt 22800 ggggccggaa ccctgcgcgc gcgagttgcg gtacacgggg ttgcagcact ggaacaccag 22860 cagggccgga ttattcacgc tggccagcag gctctcgtcg ctgatcatgt cgctgtccag 22920 atcctccgcg ttgctcaggg cgaatggggt catcttgcag acctgcctgc ccaggaaagg 22980 cgggagccca ggcttgccgt tgcagtcgca gcgcaggggc attagcaggt gcccacggcc 23040 cgactgcgcc tgcgggtaca acgcgcgcat gaaggcttcg atctgcctaa aagccacctg 23100 ggtcttggct ccctccgaaa agaacatccc acaggacttg ctggagaact gattcgcggg 23160 acagctggca tcgtgcaggc agcagcgcgc gtcagtgttg gcgatctgca ccacgttgcg 23220 accccaccgg tttttcacta tcttggcctt ggaagcctgc tcctttagcg cgcgctggcc 23280 gttctcgctg gtcacatcca tctctatcac ctgttccttg ttgatcatgt ttgtcccgtg 23340 cagacacttt aggtcgccct ccgtctgggt gcagcggtgc tcccacagcg cgcaaccggt 23400 gggctcccaa ttcttgtggg tcacccccgc gtaggcctgc aggtaggcct gcaggaagcg 23460 ccccatcatg gtcataaagg tcttctggct cgtaaaggtc agctgcaggc cgcgatgctc 23520 ttcgttcagc caggtcttgc agatggcggc cagcgcctcg gtctgctcgg gcagcatctt 23580 aaaatttgtc ttcaggtcgt tatccacgtg gtacttgtcc atcatggcac gcgccgcctc 23640 catgcccttc tcccaggcgg acaccatggg caggcttagg gggtttatca cttccagcgg 23700 cgaggacacc gtactttcga tttcttcttc ctccccctct tcccggcgcg cgcccccgct 23760 gttgcgcgct cttaccgcct gcaccaaggg gtcgtcttca ggcaagcgcc gcaccgagcg 23820 cttgccgccc ttgacctgct tgatcagtac cggcgggttg ctgaagccca ccatagtcag 23880 cgccgcctgc tcttcttcgt cttcgctgtc taccactatt tctggggagg ggcttctccg 23940 ctctgcggca aaggcggcgg atcgcttctt ttttttcttg ggagccgccg cgatggagtc 24000 cgccacggcg accgaggtcg agggcgtggg gctgggggtg cgcggcacca gggcctcgtc 24060 gccctcggac tcttcctctg actccaggcg gcggcggagt cgcttctttg ggggcgcgcg 24120 cgtcagcggc ggcggagacg gggacgggga cggggacggg acgccctcca cagggggcgg 24180 tcttcgcgca gacccgcggc cgcgctcggg ggtcttctcg cgctggtctt ggtcccgact 24240 ggccattgta tcctcctcct cctaggcaga gagacataag gagtctatca tgcaagtcga 24300 gaaggaggag agcttaacca ccccctctga gaccgccgtc gccgtcgccc ccgctaccgc 24360 cgacgcgccc gccacaccga gcgacacccc cgcggacccc cccgccgacg cacccctgtt 24420 cgaggaagcg gccgtggagc aggacccggg ctttgtctcg gcagaggagg atttgcaaga 24480 ggaggaggat aaggaggaga agccctcagt gccaaaagat cataaagagc aagacgagca 24540 cgacgcagac gcacaccagg gtgaagtcgg gcggggggac ggagggcatg gcggcgccga 24600 ctacctagac gaaggaaacg acgtgctctt gaagcacctg catcgtcagt gcgccatcgt 24660 ctgcgacgct ctgcaggagc gcagcgaggt gcccctcagc gtggcggagg tcagccgcgc 24720 ctacgagctc agcctctttt ccccccgggt gcccccccgc cgccgcgaaa acggcacatg 24780 cgagcccaac ccgcgcctca acttctaccc cgcctttgtg gtgcccgagg tcctggccac 24840 ctatcacatc ttctttcaaa attgcaagat ccccatctcg tgccgcgcca accgtagccg 24900 cgccgataag atgctggccc tgcgccaggg cgaccacata cctgatatcg ccgctttgga 24960 agatgtacca aagatcttcg agggtctggg tcgcaacgaa aagcgggcag caaactctct 25020 gcaacaggaa aacagcgaaa atgagagtca caccggggtg ctggtggagc tcgagggcga 25080 caacgcccgc ctggcggtgc tcaagcgcag catcgaggtc acccactttg cctaccccgc 25140 gctcaacctg ccccccaaag tcatgaacgc ggtcatggac gggctgatca tgcgccgcgg 25200 ccagcccctt gctccagatg caaacttgca tgaggagacc gaggacggcc agcccgtggt 25260 cagcgacgag cagctggcgc gctggctgga aaccgcggac cccgccgaac tggaggagcg 25320 gcgcaagatg atgatggccg cggtgctggt caccgtagag ctggagtgtc tgcagcgctt 25380 cttcggtgac cccgagatgc agagaaaggt cgaggagacc ctacactaca ccttccgcca 25440 gggctacgtg cgccaggctt gcaagatctc caacgtggag ctcagcaacc tggtgtccta 25500 cctgggcatc ttgcatgaga accgccttgg gcagagcgtg ctgcactcca ccctgcgcgg 25560 ggaagcgcgc cgcgactacg tgcgcgactg cgtttacctt ttcctctgct acacctggca 25620 gacggccatg ggggtctggc agcagtgcct ggaggagcgc aacctcaagg agctggagaa 25680 gctcctgcag cgcgcgctca aagacctctg gacgggcttc aacgagcgct cggtggccgc 25740 cgcgctggcc gacctcatct tccccgagcg cctgctcaaa actctccagc aggggctgcc 25800 cgacttcacc agccaaagca tgttgcaaaa ctttaggaac tttatcctgg agcgttctgg 25860 catcctaccc gccacctgct gcgccctgcc cagtgacttt gttcccctcg tgtaccgcga 25920 gtgccccccg ccgctgtggg gccactgcta cctgttccaa ctggccaact acctgtccta 25980 ccacgcggac ctcatggagg actccagcgg cgaggggctc atggagtgcc actgccgctg 26040 caacctctgc acgccccacc gctccctggt ctgcaacacc caactgctca gcgagagtca 26100 gattatcggt accttcgagc tacagggtcc gtcctcctca gacgagaagt ccgcggctcc 26160 ggggctaaaa ctcactccgg ggctgtggac ttccgcctac ctgcgcaaat ttgtacctga 26220 agactaccac gcccacgaga tcaggtttta cgaggaccaa tcccgcccgc ccaaggcgga 26280 gctgaccgcc tgcgtcatca cccagggcga gatcctaggc caattgcaag ccatccaaaa 26340 agcccgccaa gagtttttgc tgagaaaggg tcggggggtg tatctggacc cccagtcggg 26400 tgaggagctc aacccggttc ccccgctgcc gccgccgcgg gaccttgctt cccaggataa 26460 gcatcgccat ggctcccaga aagaagcagc agcggccgcc actgccgcca ccccacatgc 26520 tggaggaaga ggagtactgg gacagtcagg cagaggaggt ttcggacgag gaggagccgg 26580 agacggagat ggaagagtgg gaggaggaca gcttagacga ggaggcttcc gaagccgaag 26640 aggcaggcgc aacaccgtca ccctcggccg cagccccctc gcaggcgccc ccgaagtccg 26700 ctcccagcat cagcagcaac agcagcgcta taacctccgc tcctccaccg ccgcgaccca 26760 cggccgaccg cagacccaac cgtagatggg acaccaccgg aaccggggcc ggtaagtcct 26820 ccgggaaagg caagcaagcg cagcgccaag gctaccgctc gtggcgcgct cacaagaacg 26880 ccatagtcgc ttgcttgcaa gactgcgggg ggaacatctc cttcgcccgc cgcttcctgc 26940 tcttccacca cggtgtggcc ttcccccgta acgtcctgca ttactaccgt catctctaca 27000 gcccctactg cggcggcagt gagccagagg cggccggcgg cagcggcgcc cgtttcggtg 27060 cctaggaaga cccagggcaa gacttcagcc aagaaactcg cggcggccgc ggcgaacgcg 27120 gtcgcggggg ccctgcgcct gacggtgaac gaacccctgt cgacccgcga actgaggaac 27180 cgaatcttcc ccactctcta tgccatcttc cagcagagca gagggcagga tcaggaactg 27240 aaagtaaaaa acaggtctct gcgctccctc acccgcagct gtctgtatca caagagcgaa 27300 gaccagcttc ggcgcacgct ggaggacgct gaggcactct tcagcaaata ctgcgcgctc 27360 actcttaagg actagctccg cgcccttctc gaatttaggc gggaacgcct acgtcatcgc 27420 agcgccgccg tcatgagcaa ggacattccc acgccataca tgtggagcta tcagccgcag 27480 atgggactcg cggcgggcgc ctcccaagac tactccaccc gcatgaactg gctcagtgcc 27540 ggcccacaca tgatctcaca ggttaatgac atccgcaccc atcgaaacca aatattggtg 27600 gagcaggcgg caattaccac cacgccccgc aataatccca accccaggga gtggcccgcg 27660 tccctggtgt atcaggaaat tcccggcccc accaccgtac tacttccgcg tgattcccag 27720 gccgaagtcc aaatgactaa ctcaggggca cagctcgcgg gcggctgtcg tcacagggtg 27780 cggcctcctc gccagggtat aactcacctg gagatccgag gcagaggtat tcagctcaac 27840 gacgagtcgg tgagctcctc gctcggtctc agacctgacg ggaccttcca gatagccgga 27900 gccggccgat cttccttcac gccccgccag gcgtacctga ctctgcagag ctcgtcctcg 27960 gcgccgcgct cgggcggcat cgggactctc cagttcgtgc aggagtttgt gccctcggtc 28020 tacttcaacc ccttctcggg ctctcccggt cgctacccgg accagttcat cccgaacttt 28080 gacgccgcga gggactcggt ggacggctac gactgaatgt cgggtggacc cggtgcagag 28140 caacttcgcc tgaagcacct tgaccactgc cgccgccctc agtgctttgc ccgctgtcag 28200 accggtgagt tccagtactt ttccctgccc gactcgcacc cggacggccc ggcacacggg 28260 gtgcgctttt tcatcccgag tcaggtccgc tctaccctaa tcagggagtt tacagcccgt 28320 cccctactgg cggagttgga aaaggggcct tctatcctaa ccattgcctg catctgctct 28380 aaccctggat tacaccaaga tctttgctgt catttgtgtg ctgagtataa taaaggctga 28440 gatcagaatc tactcgggct cctgtcgcca tcctgtcaac gccaccgtcc aagcccggcc 28500 cgatcagccc gaggtgaacc tcacctgcgg tctgcaccgg cgcctgagga aatacctagc 28560 ttggtactac aacagcactc cctttgtggt ttacaacagc tttgaccagg acggggtctc 28620 actgagggat aacctctcga acctgagcta ctccatcagg aagaacaaca ccctcgagct 28680 acttcctcct tacctgcccg ggacttacca gtgtgtcacc ggtccctgca cccacaccca 28740 cctgttgatc gtaaacgact ctcttccgag aacagacctc aataactcct ctccgcagtt 28800 ccccagaaca ggaggtgagc tcaggaaacc ccgggtaaag aagggtggac aagagttaac 28860 acttgtgggg tttctggtgt atgtgacgct ggtggtggct cttttgatta aggcttttcc 28920 ttccatgtct gaactctccc tcttctttta tgaacaactc gactagtgct aacgagaccc 28980 tacccaacga atcgggattg aatatcggta accaggttgc agtttcactt ttgattacct 29040 ttatagtcct cttcctgcta gtgctgtcgc ttctgtgcct gcggatcggg ggctgctgca 29100 tccacgttta tatctggtgc tggctgttta gaaggttcgg agaccaccgc aggtagaata 29160 atgctgctta ccctctttgt cctggcgctg gctgccagct gccaagcctt ttccgaggct 29220 gacttcatag agccccagtg caatatcact tataaatctg aacgtgccat ctgtactatc 29280 ctaatcaaat gtgttactca acacgataag gtaactgtta aatacaaaga tcaattaaaa 29340 aaagacgcac tttacagcag ctggcaacca ggagatgaac aaaaatacaa tgtaaccgtc 29400 ttccagggca aactctccaa aacttacaat tacactttcc catttgagca gatgtgtgac 29460 tttgtcatgt acatggaaaa gcagtacaag ctgtggcctc caactcccca gggctgtgtg 29520 gaaaatccag gctctttctg tatgatctct ctctgtgtaa ctgtgctggc actaatactc 29580 acgcttctgt atatcagatt taaatcaagg caaagcttta ttgatgaaaa gaaaatgcct 29640 taatcgcttt cacgcttgat tgctaacacc gggtttttat ccgcagaatg attggaatca 29700 ccctactaat cacctccctc cttgcgattg cccatgggtt ggaacgaatc gaagtccctg 29760 tgggggccaa tgttaccctg gtggggcctg tcggcaatgc tacattaatg tgggaaaaat 29820 atactaaaaa tcaatgggtc tcttactgca ctaacaaaaa cagccacaag cccagagcca 29880 tctgcgatgg gcaaaattta accttgattg atgttcaatt gctggatgcg ggctactatt 29940 atgggcagct gggtacaatg attaattact ggagacccca cagagattac atgcttcacg 30000 tagtaaaggg tcccattagc agcccaacca ccacctctac cacccccact accaccacta 30060 ctcccaccac cagcactgcc gcccagcctc ctcatagcag aacaaccact tttatcaatt 30120 ccaagtccca ctccccccac attgccggcg ggccctccgc ctcagactcc gagaccaccg 30180 agatctgctt ctgcaaatgc tctgacgcca ttgcccagga tttggaagat cacgaggaag 30240 atgagcatga ctacgcagat gcatgccagg catcagagtc agaagcgctg ccggtggccc 30300 taaaacagta tgcagacccc cacaccaccc ccgaccttcc tccaccttcc cagaagccaa 30360 gtttcctggg ggaaaatgaa actctgcctc tctccatact agctctgaca tctgttgcta 30420 ttttggccgc tctgctggtg cttctatgct ctatatgcta cctgatctgc tgcagaaaga 30480 aaaaatctca cggccatgct caccagcccc tcatgcactt cccttaccct ccagagctgg 30540 gcgaccacaa actttaagtc tgcagtagct atctgcccat cccttgtcag tcgacagcga 30600 tgagccccac taatctaaca gcctctggac ttacaacatt gtctcttaat gagaccaccg 30660 ctcctcaaga cctgtacgat ggtgtctccg cgctggttaa ccagtgggat cacctgggca 30720 tatggtggct cctcatagga gcagtgaccc tgtgcctaat cctggtctgg atcatctgct 30780 gcatcaaaag cagaagaccc aggcggcggc ccatctacag gcccttcgtc atcacacctg 30840 aagataatga tgatgatgac accacctcca ggctgcagag cctaaagcag ctactcttct 30900 cttttacagc atggtaaatt gaatcatgcc ccgcattttc atctacttgc ttctccttcc 30960 actttttctg ggctcctcta cattggccgc tgtgtcccac atcgaggtag actgcctcac 31020 gcccttcaca gtctacctgc ttttcggctt tgtcatctgc acctttgtct gcagcgttat 31080 cactgtagtg atctgcttca tacagtgcat cgactacatc tgtgtgcggg tggcctactt 31140 tagacaccac ccccagtatc gcaacaggga catagcggct ctcctaagac ttgtttaaat 31200 catggccaaa ttacctgtga ttggtcttct gattatctgc tgcgtcctag ccgcgattgg 31260 gactcaacct aataccacca ccagcgctcc cagaaagaga catgtatcct gcagcttcaa 31320 gcgtccctgg aatatacccc aatgctttac tgatgaacct gaaatctctt tggcttggta 31380 cttcagcgtc accgcccttc tcatcttctg cagtacggtt attgctcttg ccatctaccc 31440 ttcccttaac ctgggctgga atgctgtcaa ctctatggaa tatcccacct tcccagaacc 31500 agacctgcca gacctggttg ttctaaacgc gtttcctcct cctccagttc aaaatcagtt 31560 tcgccctccg tcccctacgc ccactgaggt cagctacttt aatctaacag gcggagatga 31620 ctgaaaacct agacctagaa atggacggtc tctgcagcga gcaacgcaca ctagagaggc 31680 gccggcaaaa agcagagctc gagcgtctta aacaagagct ccaagacgcc gtggccatac 31740 accagtgcaa aaaagggctc ttctgtctgg taaaacaggc cacgctcacc tatgaaaaaa 31800 caggtgacac ccaccgccta ggatacaagc tgcccacaca gcgccaaaag tttgccctta 31860 tgataggtga acaacccatc accgtcaccc agcactccgt ggagacagaa ggctgcattc 31920 atgctccctg caggggcgct gactgcctct acaccttgat caaaaccctc tgcggtctca 31980 gagaccttat ccctttcaat tgatcataac tgtaatcaat aaaaaatcac ttacttgaaa 32040 tctgatagca agcctctgtc caattttttc agcaacactt ccttcccctc ttcccaactc 32100 tggtactcta ggcgcctcct agctgcaaac ttcctccaca gtctgaaggg aatgtcagat 32160 tcctcctcct cctgtccctc cgcacccaca atcttcatgt tgttgcagat gaaacgcgcg 32220 agatcgtctg acgagacctt caaccccgtg tacccctacg ataccgagat cgctccgact 32280 tctgtccctt tccttacccc tccctttgtg tcacccgcag gaatgcaaga aaatccagct 32340 ggggtgctgt ccctgcacct gtcagagccc cttaccaccc acaatggggc cctgactcta 32400 aaaatggggg gcggcctgac cctggacaag gaagggaatc tcacttccca aaacatcacc 32460 agtgtcgatc cccctctcaa aaaaagcaag aacaacatca gccttcagac cgccgcaccc 32520 ctcgccgtca gctccggggc cctaaccctt tttgccactc cccccctagc ggtcagtggc 32580 gacaacctta ctgtgcagtc tcaggcccct cttactttgg aagactcaaa actaactctg 32640 gccaccaaag gacccctaac tgtgtccgaa ggcaaacttg tcctagaaac agaggctccc 32700 ctgcatgcaa gtgacagcag tagcctgggc cttagcgtca cggccccact tagcattaac 32760 aatgacagcc taggactaga tctgcaggca cccattgtct ctcaaaatgg aaaactggct 32820 ctaaatatag caggccccct agctgtagcc gatagcatta atgctttgac agtaggcact 32880 ggcaaaggta ttggactaaa tgaaaccagc actcacttgc aagcaaaatt ggttgccccc 32940 ctaggctttg ataccaatgg caatattaag ctaagcgttg caggaggcat gaggctaaac 33000 aatgacacac tgatactaga tgtaaactac ccatttgaag ctcaaggtca actaagccta 33060 agagtgggca caggtccact gtatgtagat tctagcagtc ataatctaac cattagatgc 33120 cttaggggat tgtatataac atcatctaac aaccaaaacg gtctagaggc caacattaaa 33180 ctaacaaaag gccttgtgta tgaaggaaat gccatagcag ttaatgttgg tcaaggattg 33240 caatacagca ctactgccac atcggaaggt gtgtatccta tacagtctaa gataggtttg 33300 ggaatggaat atgataccaa cggagccatg atggcaaaac taggctccgg tctaagcttt 33360 gataattcag gagccattgt ggtgggaaac aaaaatgatg acaaacttac cctatggacc 33420 acacctgacc cgtctcctaa ctgtagaatt tattctgaaa aagatactaa actaaccttg 33480 gtgctgacta agtgtggcag tcaaatccta ggcacagtat ctgcccttgc tgtcagaggc 33540 agccttgcgc ccatcactaa cgcatccagc atagtccaaa tatttctacg atttgatgaa 33600 aatggactat tgatgagcaa ctcatcgcta gacggtgatt actggaatta cagaaatggg 33660 gactccacta atggcacacc atatacaaat gcagtaggct ttatgcctaa tctagctgcc 33720 tatcctaaag gtcaggctac aactgcaaaa agcagtattg taagccaggt atacatggat 33780 ggtgatacta ctaaacctat aacactaaaa ataaacttta atggcattga tgaaacaaca 33840 gaaaataccc ctgttagtaa atattccatg acattctcat ggagctggcc caccgcaagc 33900 tacataggcc acacttttgc aacaaactct tttactttct cctacatcgc ccaagaataa 33960 agaaagcaca gagatgcttg tttttgattt caaaattgtg tgcttttatt tattttcaag 34020 cttacagtat ttccagtagt cattcaaata gagcttaatg aaactgcatg agaacccttc 34080 cacatagctt aaattatcac cagtgcaaat ggagaaaaaa tcaacatacc tttttatcca 34140 gatatcatag aactctagtg gtcagttttc ccccaccctc ccagctcaca gaatacacag 34200 tcctttcccc ccggctggct ttaaacaaca ctatctcatt ggtaacagac atattcttag 34260 gtgtaataat ccacacggtc tcttggcggg ccaaacgctg gtcagtgatg ttaataaact 34320 ccccaggcag ctctttcaag ttcacgtcgc tgtccaactg ctgaagcgct cgcggctccg 34380 actgcgcctc tagcggaggc aacggcaaca cccgatcctt gatctataaa ggagtagagt 34440 cataatcccc cataagaata gggcggtgat gctgcaacaa ggcgcgcagc aactcctgcc 34500 gccgcctttc cgtacgacag gaatgcaacg gggtggtggt ctcctccgcg ataatccgca 34560 ccgctcgcaa catcagcgtc ctcgtcctcc gggcacagca gcgcatcctg atctcactga 34620 gatcggcgca gtaagtgcag cacaacacca agatgttatt taagatccca cagtgcaaag 34680 cactgtaccc aaagctcatg gcgggaagga cagcccccac gtgaccatca taccagatcc 34740 tcaggtaaat caaatgacga cctctcatga acacgctgga catgtacatc acctccttag 34800 gcatgtgctg attcaccacc tctcgatacc acaggcatcg ctgattaatt aaagacccct 34860 cgagcaccat cctgaaccag gaagccagca cctgaccccc cgccaggcac tgcagggacc 34920 ccggtgaatc gcagtggcag tgaagactcc agcgctcgta gccgtgaacc atagagctgg 34980 tcattatatc cacattggca caacacagac acactttcat acactttttc atgattagca 35040 gctcctctct agtcaggacc atatcccaag gaatcaccca ctcttgaatc aaggtaaatc 35100 ccacacagca gggcaggcct ctcacataac tcacgttatg catagtgagc gtgtcgcaat 35160 ctggaaatac cggatgatct tccatcaccg aagcccgggt ctccgtctca aagggaggta 35220 aacggtccct cgtgtaggga cagtggcggg ataatcgaga tcgtgttgaa cgtagagtca 35280 tgccaaaggg aacagcggac gtactcatat ttcctccagc agaaccaagt gcgcgcgtgg 35340 cagctatcct tgcgtcttct gtctcgccgc ctgccccgct cggtgtagta gttgtaatac 35400 agccactccc tcagaccgtc aaggcgctcc ctggcgtccg gatctataac aacaccatcc 35460 tgcagcgccg ccctgatgac atccaccacc gtagagtatg ccaagcccag ccaggaaatg 35520 cactcacttt gacagcgaga gataggagga gcgggaagag atggaagaac catgatagta 35580 aaagaacttt tattccaatc gatcctctac aatgtcaaag tgtagatcta tcagatggca 35640 ctggtctcct ccgctgagtc gatcaaaaat aacagctaaa ccacaaacaa cacgattggt 35700 caaatgctgc acaagggctt gcagcataaa atcgcctcga aagtccaccg caagcataac 35760 atcaaagcca ccgcccctat catgatctat gataaaaacc ccacagctat ccaccagacc 35820 catatagttt tcatctctcc atcgtgaaaa aatatttaca agctcctcct ttaaatcacc 35880 tccaaccaat tcaaaaagtt gagccagacc gccctccacc ttcattttca gcatgcgcat 35940 catgattgca aaaattcagg ctcctcagac acctgtataa gattgagaag cggaacgtta 36000 acatcaatgt ttcgctcgcg aagatcgcgc ctcagtgcaa gcatgatata atcccacagg 36060 tcggagcgga tcagcgagga catctccccg ccaggaacca actcaacgga gcctatgctg 36120 attataatac gcatattcgg ggctatgcta accagcacgg cccccaaata ggcgtactgc 36180 ataggcggcg acaaaaagtg aacagtttgg gttaaaaaat caggcaaaca ctcgcgcaaa 36240 aaagcaagaa catcataacc atgctcatgc aaatagatgc aagtaagctc aggaacgacc 36300 acagaaaaat gcacaatttt tctctcaaac atgactgcga gccctgcaaa aataaaaaag 36360 aaacattaca caagagtagc ctgtcttaca atgggataga ctactctaac caacataaga 36420 cgggccacaa catcgcccgc gtggccataa aaaaaattat ccgtgtgatt aaaaagaagc 36480 acagatagct ggccagtcat atccggagtc atcacgtgcg aacccgtgta gacccccggg 36540 ttggacacat cggccaaaca aagaaagcgg ccaatgtatc ccggaggaat gataacacta 36600 agacgaagat acaacagaat aaccccatgg gggggaataa caaagttagt aggtgaataa 36660 aaacgataaa cacccgaaac tccctcctgc gtaggcaaaa tagcgccctc cccttccaaa 36720 acaacatata gcgcttccac agcagccatg acaaaagact caaaacactc aaaagactca 36780 gtcttaccag gaaaataaaa gcactctcac agcaccagca ctaatcagag tgtgaaaaag 36840 gccaagtgcc gaacgagtat atataggaat taaaaatgac gtaaatgtgt aaaggtcaga 36900 aaacgcccag aaaaatacac agaccaacgc ccgaaacgaa aacccgcgaa aaaataccca 36960 gaagttcctc aacaaccgcc acttccgctt tcccacgaga cgtcacttcc tcaaaaatag 37020 caaactacat ttcccacata tacaaaacca aaacccctcc ccttgtcacc gcccacaact 37080 tacatcatca caaacgtcaa agcctacgtc acccgccccg cccacctcat tatcatattg 37140 gccacaatcc aaaataaggt atattattga tgatg 37175 <210> 9 <211> 37190 <212> DNA <213> Great Ape Adenovirus <400> 9 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaact caggcggccg aggaagctgt tgacgaggaa gatgcagaag 19440 atgaagcgca accacaagag gaagcccctg ttaaaaaaat tcatgtatat gctcaggcgc 19500 ctcttgctgg cgaaaagatt accaaggatg gtttgcaaat aggtactgaa gtcgtaggag 19560 atacatctaa ggacactttt gcagataaaa cattccaacc cgaacctcag ataggcgagt 19620 ctcagtggaa cgaggctgat gccgcagtag caggaggtag agttttgaaa aagactaccc 19680 ctatgagacc ttgctatgga tcctatgcca ggcctaccaa tgccaacggg ggtcaaggaa 19740 ttatggttgc caatgaaaaa ggagtgttgc agtctaaagt agaaatgcaa tttttctcta 19800 acacctcaac ccttaatgcg cgggatggaa ccggcaatcc cgaaccaaag gtggtgttgt 19860 acagcgaaga tgtccacttg gaatctcccg atactcatct gtcttacaag cccacaaagg 19920 atgatgttaa tgccaaagtc atgttgggtc agcaagccat gcccaacaga cccaacctca 19980 ttggatttag agataatttc attgggctta tgttttacaa cagcaccggt aacatgggag 20040 tgctggcggg tcaggcctct cagttgaatg ctgtggtgga cttgcaggat agaaacacag 20100 aactgtcata tcagcttatg cttgattcaa ttggggatag aaccagatac ttctccatgt 20160 ggaaccaggc agtggatagc tatgatccag atgtcagaat tattgaaaac catggggttg 20220 aggatgaact gcccaactac tgcttccctt tgggcggcat aggaattact gatacttatc 20280 aaggggtgaa aaataccaat ggcaatggtc agtggaccaa agatgatcag ttcgcggacc 20340 gcaacgaaat aggggtggga aacaacttcg ccatggagat caacatccag gccaaccttt 20400 ggagaaactt cctctatgca aacgtggggc tctacctgcc agacaagctc aagtacaacc 20460 ccaccaacgt ggacatctct gacaacccca acacctatga ctacatgaac aagcgggtgg 20520 tggcccctgg cctggtggac tgctttgtca atgtgggagc caggtggtcc ctggactaca 20580 tggacaacgt caaccccttc aaccaccacc gcaatgcggg tctgcgctac cgctccatga 20640 tcctgggcaa cgggcgctat gtgccctttc acatccaggt accccagaag ttctttgcca 20700 tcaagaacct cctgctcctg cccggctcct acacctacga gtggaacttc aggaaggatg 20760 tgaacatggt cctacagagc tctctgggca atgaccttag ggtggatggg gccagcatca 20820 agtttgacag catcaccctc tatgctacat ttttccccat ggcccacaac accgcctcca 20880 cgcttgaggc catgctgaga aacgacacca acgaccagtc ctttaatgac tacctctctg 20940 gggccaacat gctctaccca atcccagcca aggccaccaa cgtgcccatc tccatcccct 21000 ctcgcaactg ggccgccttt agaggctggg cctttacccg ccttaagacc aaggagaccc 21060 cctccctggg ctcgggtttt gatccctact ttgtttactc gggatccatc ccctacctgg 21120 atggcacctt ctacctcaac cacactttca agaagatatc catcatgtat gactcctccg 21180 tcagctggcc gggcaacgac cgcttgctca cccccaatga gttcgaggtc aagcgcgccg 21240 tggacggcga gggctacaac gtggcccagt gcaacatgac caaggactgg ttcctggtgc 21300 agatgctggc caactacaac ataggctacc agggctttta catcccagag agctacaagg 21360 acaggatgta ctccttcttc agaaatttcc aacccatgag ccgacaggtg gtggacgaga 21420 ccaattacaa ggactatcaa gccattggca tcacccacca gcacaacaac tcgggtttcg 21480 tgggctacct ggcgcccacc atgcgcgagg gtcaggccta ccccgccaac ttcccctacc 21540 ccttgatagg caagaccgcg gtcgacagcg tcacccagaa aaagttcctc tgcgaccgca 21600 ccctctggcg catccccttc tctagcaact tcatgtccat gggtgcgctc acggacctgg 21660 gccaaaacct gctttatgcc aactctgccc atgcgctgga catgactttt gaggtggacc 21720 ccatggacga gcccaccctt ctctatattg tgtttgaagt gttcgacgtg gtcagagtgc 21780 accagccgca ccgcggtgtc atcgagaccg tgtacctgcg tacgcccttc tcagccggca 21840 acgccaccac ctaaggagac agcgccgccg ccgcctgcat gacgggttcc accgagcaag 21900 agctcagggc cattgccaga gacctgggat gcggacccta ttttttgggc acctatgaca 21960 aacgcttccc gggctttatc tcccgagaca agctcgcctg cgccattgtc aacacggccg 22020 cgcgcgagac cgggggcgtg cactggctgg cctttggctg ggacccgcgc tccaaaactt 22080 gctacctctt tgaccccttt ggcttctccg atcagcgcct caggcagatt tatgagtttg 22140 agtacgaggg gctgctgcgc cgcagcgcgc tcgcctcctc gcccgaccgc tgcatcaccc 22200 ttgagaagtc caccgaaacc gtgcaggggc cccactcggc cgcctgcggt ctcttctgtt 22260 gcatgttttt gcacgccttt gtgcactggc ctcagagtcc catggattgc aaccccacca 22320 tgaacttgct aaagggagtg cccaacgcca tgctccagag cccccaggtc cagcccaccc 22380 tgcgccgcaa ccaggaacag ctttaccgct tcctggagcg ccactccccc tacttccgca 22440 gccacagcgc gcgcatccgg ggggccacct ctttttgcca cttgcaagaa aacatgcaag 22500 acggaaaatg atgtacagca tgcttttaat aaatgtaaag actgtgcact ttaattatac 22560 acgggctctt tctggttatt tattcaacac cgccgtcgcc atttagaaat cgaaagggtt 22620 ctgccgtgcg tcgccgtgcg ccacgggcag agacacgttg cgatactgga agcggctcgc 22680 ccacttgaac tcgggcacca ccatgcgggg cagtggttcc tcggggaagt tctcgctcca 22740 cagggtgcgg gtcagctgca gcgcgctcag gaggtcggga gccgagatct tgaagtcgca 22800 gttggggccg gaaccctgcg cgcgcgagtt gcggtacacg gggttgcagc actggaacac 22860 cagcagggcc ggattattca cgctggccag caggctctcg tcgctgatca tgtcgctgtc 22920 cagatcctcc gcgttgctca gggcgaatgg ggtcatcttg cagacctgcc tgcccaggaa 22980 aggcgggagc ccaggcttgc cgttgcagtc gcagcgcagg ggcattagca ggtgcccacg 23040 gcccgactgc gcctgcgggt acaacgcgcg catgaaggct tcgatctgcc taaaagccac 23100 ctgggtcttg gctccctccg aaaagaacat cccacaggac ttgctggaga actggttcgc 23160 gggacagctg gcatcgtgca ggcagcagcg cgcgtcagtg ttggcaatct gcaccacgtt 23220 gcgaccccac cggtttttca ctatcttggc cttggaagcc tgctccttta gcgcgcgctg 23280 gccgttctcg ctggtcacat ccatctctat cacctgttcc ttgttgatca tgtttgtccc 23340 gtgcagacac tttaggtcgc cctccgtctg ggtgcagcgg tgctcccaca gcgcgcaacc 23400 ggtgggctcc caattcttgt gggtcacccc cgcgtaggcc tgcaggtagg cctgcaggaa 23460 gcgccccatc atggtcataa aggtcttctg gctcgtaaag gtcagctgca ggccgcgatg 23520 ctcttcgttc agccaggtct tgcagatggc ggccagcgcc tcggtctgct cgggcagcat 23580 cttaaaattt gtcttcaggt cgttatccac gtggtacttg tccatcatgg cacgcgccgc 23640 ctccatgccc ttctcccagg cggacaccat gggcaggctt agggggttta tcacttccag 23700 cggcgaggac accgtacttt cgatttcttc ttcctccccc tcttcccggc gcgcgccccc 23760 gctgttgcgc gctcttaccg cctgcaccaa ggggtcgtct tcaggcaagc gccgcaccga 23820 gcgcttgccg cccttgacct gcttgatcag taccggcggg ttgctgaagc ccaccatggt 23880 cagcgccgcc tgctcttctt cgtcttcgct gtctaccact atttctgggg aggggcttct 23940 ccgctctgcg gcaaaggcgg cggatcgctt cttttttttc ttgggagccg ccgcgatgga 24000 gtccgccacg gcgaccgagg tcgagggcgt ggggctgggg gtgcgcggta ccagggcctc 24060 gtcgccctcg gactcttcct ctgactccag gcggcggcgg agtcgcttct ttgggggcgc 24120 gcgcgtcagc ggcggcggag acggggacgg ggacggggac gggacgccct ccacaggggg 24180 tggtcttcgc gcagacccgc ggccgcgctc gggggtcttc tcgcgctggt cttggtcccg 24240 actggccatt gtatcctcct cctcctaggc agagagacat aaggagtcta tcatgcaagt 24300 cgagaaggag gagagcttaa ccaccccctc agagaccgcc gatgcgcccg ccgtcgccgt 24360 cgcccccgct accgccgacg cgcccgccac accgagcgac acccccacgg acccccccgc 24420 cgacgcaccc ctgttcgagg aagcggccgt ggagcaggac ccgggctttg tctcggcaga 24480 ggaggatttg caagaggagg agaataagga ggagaagccc tcagtgccaa aagatcataa 24540 agagcaagac gagcacgacg cagacgcaca ccagggtgaa gtcgggcggg gggacggagg 24600 gcatggcggc gccgactacc tagacgaagg aaacgacgtg ctcttgaagc acctgcatcg 24660 tcagtgcgcc atcgtctgcg acgctctgca ggagcgcagc gaggtgcccc tcagcgtggc 24720 ggaggtcagc cgcgcctacg agctcagcct cttttccccc cgggtgcccc cccgccgccg 24780 cgaaaacggc acatgcgagc ccaacccgcg cctcaacttc taccccgcct ttgtggtgcc 24840 cgaggtcctg gccacctatc acatcttctt tcaaaattgc aagatcccca tctcgtgccg 24900 cgccaaccgt agccgcgccg ataagatgct ggccctgcgc cagggcgacc acatacctga 24960 tatcgccgct ttggaagatg tgccaaagat cttcgagggt ctggggcgca acgagaagcg 25020 ggcagcaaac tctctgcaac aggaaaacag cgaaaatgag agtcacactg gagcgctggt 25080 ggagctggag ggcgacaacg cccgcctggc ggtgctcaag cgcagcatcg aggtcaccca 25140 ctttgcctac cccgcgctca acctgccccc caaagtcatg aacgcggtca tggacgggct 25200 gatcatgcgc cgcggccggc ccctcgctcc agatgcaaac ttgcatgagg agaccgagga 25260 cggtcagccc gtggtcagcg acgagcagct gacgcgctgg ctggagagcg cggaccccgc 25320 cgaactggag gagcggcgca agatgatgat ggccgcggtg ctggtcaccg tagagctgga 25380 gtgtctgcag cgcttcttcg gtgaccccga gatgcagaga aaggtcgagg agaccctaca 25440 ctacaccttc cgccagggct acgtgcgcca ggcttgcaag atctccaacg tggagctcag 25500 caacctggtg tcctacctgg gcatcttgca tgaaaaccgc cttgggcaga gcgtgctaca 25560 ctccaccctg cgcggggagg cgcgccgcga ctacgtgcgc gactgcgttt acctcttcct 25620 ctgctacacc tggcagacgg ccatgggggt ctggcagcag tgcctggagg agcgcaacct 25680 caaggagctg gagaagcttc tgcagcgcgc gctcaaagac ctctggacgg gcttcaacga 25740 gcgctcggtg gccgccgcgc tagccgacct catcttcccc gagcgcctgc tcaaaaccct 25800 ccagcagggg ctgcccgact tcaccagcca aagcatgttg caaaatttta ggaactttat 25860 cctggagcgt tctggcatcc tacccgccac ctgctgcgcc ctgcccagcg actttgtccc 25920 cctcgtgtac cgcgagtgcc ccccgccgct gtggggccac tgctacctgt tccaactggc 25980 caactacctg tcctaccacg cggacctcat ggaggactcc agcggcgagg ggctcatgga 26040 gtgccactgc cgctgcaacc tctgcacgcc ccaccgctcc ctggtctgca acacccaact 26100 gctcagcgag agtcagatta tcggtacctt cgagctacag ggtccgtcct cctcagacga 26160 gaagtccgcg gctccggggc taaaactcac tccggggctg tggacttccg cctacctgcg 26220 caaatttgta cctgaagact accacgccca cgaaatcagg ttttacgagg accaatcccg 26280 cccgcccaag gcggagctga ccgcctgcgt catcacccag ggcgagatcc taggccaatt 26340 gcaagccatc caaaaagccc gccaagagtt tttgctgaag aggggtcggg gggtgtatct 26400 ggacccccag tcgggtgagg agctcaaccc ggttcccccg ctgccaccgc cgcgggacct 26460 tgcttcccag gataagcatc gccatggctc ccagaaagaa gcagcagcgg ccgccgctgc 26520 cgccgcccca catgctggag gaagaggagg aatactggga cagtcaggca gaggaggttt 26580 cggacgagga ggagccggag acggagatgg aagagtggga ggaggacagc ttagacgagg 26640 aggcttccga agccgaagag gcaggcgcaa caccgtcacc ctcggccgca gccccctcgc 26700 aggcgccccc gaagtccgct cccagcatca gcagcaacag cagcgctata acctccgctc 26760 ctccaccgcc gcgacccacg gccgaccgca gacccaaccg tagatgggac accaccggaa 26820 ccggggccgg taagtcctcc gggagaggca agcaagcgca gcgccaaggc taccgctcgt 26880 ggcgcgctca caagaacgcc atagtcgctt gcttgcaaga ctgcgggggg aacatctcct 26940 tcgcccgccg cttcctgctc ttccaccacg gtgtggcctt cccccgtaac gtcctgcatt 27000 actaccgtca tctctacagc ccctactgcg gcggcagtga gccagaggcg gccagcggcg 27060 gcggcgcccg tttcggtgcc taggaagacc cagggcaaga cttcagccaa gaaactcgcg 27120 gcgaccgcgg cgaacgcggt cgcgggggcc ctgcgcctga cggtgaacga acccctgtcg 27180 acccgcgaac tgaggaaccg aatcttcccc actctctatg ccatcttcca gcagagcaga 27240 gggcaggatc aggaactgaa agtaaaaaac aggtctctgc gctccctcac ccgcagctgt 27300 ctgtatcaca agagcgaaga ccagcttcgg cgcacgctgg aggacgctga ggcactcttc 27360 agcaaatact gcgcgctcac tcttaaggac tagctccgcg cccttctcga atttaggcgg 27420 gaacgcctac gtcatcgcag cgccgccgtc atgagcaagg acattcccac gccatacatg 27480 tggagctatc agccgcagat gggactcgcg gcgggcgcct cccaagacta ctccacccgc 27540 atgaactggc tcagtgccgg cccacacatg atctcacagg ttaatgacat ccgcacccat 27600 cgaaaccaaa tattggtgaa gcaggcggca attaccacca cgccccgcaa taatcccaac 27660 cccagggagt ggcccgcgtc cctggtgtat caggaaattc ccggccccac caccgtacta 27720 cttccgcgtg attcccaggc cgaagtccaa atgactaact caggggcaca gctcgcgggc 27780 ggctgtcgtc acagggtgcg gcctcctcgc cagggtataa ctcacctgga gatccgaggc 27840 agaggtattc agctcaacga cgagtcggtg agctcctcgc tcggtctcag acctgacggg 27900 accttccaga tagccggagc cggccgatct tccttcacgc cccgccaggc gtacctgact 27960 ctgcagagct cgtcctcggc gccgcgctcg ggcggcatcg ggactctcca gttcgtgcag 28020 gagtttgtgc cctcggtcta cttcaacccc ttctcgggct ctcccggtcg ctacccggac 28080 cagtttatcc cgaactttga cgccgcgagg gactcggtgg acggctacga ctgaatgtcg 28140 ggtggacccg gtgcagagca acttcgcctg aagcaccttg accactgccg ccgccctcag 28200 tgctttgccc gctgtcagac cggtgagttc cagtactttt ccctgcccga ctcgcacccg 28260 gacggcccgg cgcacggggt gcgctttttc atcccgagtc aggtccgctc taccctaatc 28320 agggagttca ccgcccgtcc cctactggcg gagttggaaa aggggccttc tatcctaacc 28380 attgcctgca tttgctctaa ccctggatta caccaagatc tttgctgtca tttgtgtgct 28440 gagtataata aaggctgaga tcagaatcta ctcgggctcc tgtcgccatc ctgtcaacgc 28500 caccgtccaa gcccggcccg atcagcccga ggtgaacctc acctgtggtc tgcaccggcg 28560 cctgaggaaa tacctagctt ggtactacaa cagcactccc tttgtggttt acaacagctt 28620 tgaccaggac ggggtctcac tgagggataa cctctcgaac ctgagctact ccatcaggaa 28680 gaacaacacc ctcgagctac ttcctcctta cctgcccggg acttaccagt gtgtcaccgg 28740 cccctgcacc cacacccacc tgttgatcgt aaacgactct cttccgagaa cagacctcaa 28800 taactcctct ccgcagttcc ccagaacagg aggtgagctc aggaaacccc gggtaaagaa 28860 gggtggacaa gagttaacac ttgtggggtt tctggtatat gtgacgctgg tggtggctct 28920 tttgattaag gcttttcctt ccatgtctga actatccctc ttcttttatg aacaactcga 28980 ctagtgctaa cgggacccta cccaacgaat cgggattgaa tatcggtaac caggttgcag 29040 tttcactttt gattaccttc atagtcctct tcctgctagt gctgtcgctt ctgtgcctgc 29100 ggatcggggg ctgctgcatc cacgtttata tctggtgctg gctgtttaga aggttcggag 29160 accaccgcag gtagaataat gctgcttacc ctctttgtcc tggcgctggc tgccagctgc 29220 caagcctttt ccgaggctga cttcatagag ccccagtgca atatcactta taaatctgaa 29280 cgtgccatct gtactattct aatcaaatgt gttactcaac acgataaggt gactgttaaa 29340 tacaaagatc aattaaaaaa agacgcactt tacagcagct ggcaaccagg agatgatcaa 29400 aaatacaatg taaccgtctt ccagggcaaa ctctccaaaa cttacaatta caatttccca 29460 tttgagcaga tgtgtgactt tgtcatgtac atggaaaagc agtacaagct gtggcctcca 29520 actccccagg gctgtgtgga aaatccaggc tctttctgta tgatctctct ctgtgtaact 29580 gtgctggcac taatactcac gcttctgtat ctcagattta aatcaaggca aagcttcatt 29640 gatgaaaaga aaatgccata atcgctcaac gcttgattgc taacaccggg tttttatccg 29700 cagaatgatt ggaatcaccc tactaatcac ctccctcctt gcgattgccc atgggttgga 29760 acgaatcgaa gtccctgtgg gggccaatgt taccctggtg gggcctgtcg gcaatgctac 29820 attaatgtgg gaaaaatata ctaaaaatca atgggtttct tactgcacta acaaaaacag 29880 ccacaagccc agagccatct gcgatgggca aaatctaacc ttgattgatg ttcaattgct 29940 ggatgcgggc tactattatg ggcagctggg tacaatgatt aattactgga gaccccacag 30000 agattacatg cttcacgtag taaagggtcc cattagcagc ccaaccacca cctctaccac 30060 acccactacc accactactc ccaccaccag cactgccgcc cagcctcctc atagcagaac 30120 aaccactttt atcaattcca agtcccactc cccccacatt gccggcgggc cctccgcctc 30180 agactccgag accaccgaga tctgcttctg caaatgctct gacgccattg cccaggattt 30240 ggaagatcac gaggaagatg agcatgacta cgcagatgca tgccaggcat cagaggcaga 30300 agcgctaccg gtggccctaa aacagtatgc agactcccac accaccccca accttcctcc 30360 accttcccag aagccaagtt tcctggggga aaatgaaact ctgcctcttt ccatactagc 30420 tctgacatct gttgctattt tggccgctct gctggtgctt ctatgctcta tatgctacct 30480 gatctgctgc agaaagaaaa aatctcacgg ccatgctcac cagcccctca tgcacttccc 30540 ttaccctcca gagctgggcg accacaaact ttaagtctgc agtagctatc tgcccatccc 30600 ttgtcagtcg acagcgatga gccccactaa tctaacagcc tctggactta caacattgtc 30660 tcttaatgag accaccgctc ctcaagacct gtacgatggt gtctccgcgc tggttaacca 30720 gtgggatcac ctgggcatat ggtggctcct cataggagca gtgaccctgt gcctaatcct 30780 ggtctggatc atctgctgca tcaaaagcag aagacccagg cggcggccca tctacaggcc 30840 cttcgtcatc acacctgaag ataatgatga tgatgacacc acctccaggc tgcagagcct 30900 aaagcagcta ctcttctctt ttacagcatg gtaaattgaa tcatgccccg cattttcatc 30960 tacttgcttc tccttccact ttttctgggc tcctctacat tggccactgt gtcccacatc 31020 gaggtagact gcctcacgcc cttcacagtc tacctgcttt tcggctttgt catctgcacc 31080 tttgtctgca gcgttatcac tgtagtgatc tgcttcatac agtgcatcga ctacatctgt 31140 gtgcgggtgg cctactttag acaccacccc cagtatcgca acagggacat agcggctctc 31200 ctaagacttg tttaaatcat ggccaaatta cctgtgattg gtcttctgat tatctgctgc 31260 gtcctagccg cgattgggac tcaacctaat accaccacca gcgctcccag aaagagacat 31320 gtatcctgca gcttcaagcg tccctggaat ataccccaat gctttactga tgaacctgaa 31380 atctctttgg cttggtactt cagcgtcacc gcccttctca tcttctgcag tacggttatt 31440 gctcttgcca tctacccttc ccttaacctg ggctggaatg ctgtcaactc tatggaatat 31500 cccaccttcc cagaaccaga cctgccagac ctggttgttc taaacgcgtt tcctcctcct 31560 ccagttcaaa atcagtttcg ccctccgtcc cctacgccca ctgaggtcag ctactttaat 31620 ctaacaggcg gagatgactg aaaacctaga cctagaaatg gacggtctct gcagcgagca 31680 acgcacacta gagaggcgcc ggcaaaaagc agagctcgag cgtcttaaac aagagctcca 31740 agacgccgtg gccatacacc agtgcaaaaa agggctcttc tgtctggtaa aacaggccac 31800 gctcacctat gaaaaaacag gtgacaccca ccgcctagga tacaagctgc ccacacagcg 31860 ccaaaagttt gcccttatga taggtgaaca acccatcacc gtcacccagc actccgtgga 31920 gacagaaggc tgcattcatg ctccctgcag gggcgctgac tgcctctaca ccttgatcaa 31980 aaccctctgc ggtctcagag accttatccc tttcaattga tcataactgt aatcaataaa 32040 aaatcactta cttgaaatct gatagcaaga ctctgtccaa ttttttcagc aacacttcct 32100 tcccctcctc ccaactctgg tactctaggc gcctcctagc tgcaaacttc ctccacagtc 32160 tgaagggaat gtcagattcc tcctcctgtc cctccgcacc cacgatcttc atgttgttac 32220 agatgaaacg cgcgagatcg tctgacgaga ccttcaaccc cgtgtacccc tacgataccg 32280 agatcgctcc gacttctgtc cctttcctta cccctccctt tgtatcatcc gcaggaatgc 32340 aagaaaatcc agctggggtg ctgtccctgc acctgtcaga gccccttacc acccacaatg 32400 gggccctgac tctaaaaatg gggggcggcc tgaccctgga caaggaaggg aatctcactt 32460 cccaaaacat caccagtgtc gatccccctc tcaaaaaaag caagaacaac atcagccttc 32520 agaccgccgc acccctcgcc gtcagctccg gggccctaac cctttttgcc actccccccc 32580 tagcggtcag tggcgacaac cttactgtgc agtctcaggc ccctcttact ttggaagact 32640 caaaactaac tctggccacc aaaggacccc taactgtgtc cgaaggcaaa cttgtcctag 32700 aaacagagcc tcccctgcat gcaagtgaca gcagtagcct gggccttagc gtcacggccc 32760 cacttagcat taacaatgac agcctaggac tagacatgca agcgcccatc agctctcgag 32820 atggaaaact ggctctaaca gtggcggccc ccctaactgt ggccgagggt atcaatgctt 32880 tggcagtagc cacaggtaat ggtattggac taaatgaaac caacacacac ctgcaggcaa 32940 aactggtcgc gcccctaggc tttgatacca acggcaacat taagctaagc gtcgcaggag 33000 gcatgaggct aaacaataac acactgatac tagatgtaaa ctacccattt gaggctcaag 33060 gccaactgag cctaagagtg ggctcgggcc cactatatgt agattctagt agtcataacc 33120 taaccattag atgccttagg ggattgtatg taacatcttc taacaaccaa aacggtctag 33180 aggccaacat taaactaaca aaaggccttg tgtatgacgg aaatgccata gcagttaatg 33240 ttggcaaagg gctggaatac agccctactg gcacaacaga aaaacctata cagactaaaa 33300 taggtctagg catggagtat gacactgagg gagccatgat gacaaaacta ggctctggac 33360 taagctttga caattcagga gccattgtgg tgggaaacaa aaatgatgac aggcttactt 33420 tgtggaccac accggaccca tcgcccaact gtcagattta ctctgaaaaa gatgctaaac 33480 taaccttggt actgactaaa tgtggcagtc aggttgtagg cacagtatct attgccgctc 33540 ttaaaggtag ccttgtgcca atcactagtg caatcagtgt ggttcagata tacctaaggt 33600 ttgatgaaaa tggggtgctg atgagtaact cttcacttaa tggcgaatac tggaatttta 33660 gaaacggaga ctcaactaat ggcacaccat atacaaacgc agtgggtttt atgcctaatc 33720 tactggccta tcctaaaggt caaactacaa ctgcaaaaag taacattgtc agccaggtct 33780 acatgaacgg ggacgatact aaacccatga catttacaat caacttcaat ggccttagtg 33840 aaacagggga tacccctgtc agtaaatatt ccatgacatt ctcatggagg tggccaaatg 33900 gaagctacat agggcacaat tttgtaacaa actcctttac tttctcctac atcgcccaag 33960 aataaagaaa gcacagagat gcttgttttt gatttcaaaa ttgtgtgctt ttatttattt 34020 tcaagcttac agtatttcca gtagtcatta gaatagagct taattaaact gcatgagaac 34080 ccttccacat agcttaaatt atcaccagtg caaatggaaa aaaatcaaca taccttttta 34140 tccagatatc aaagaactct agtggtcagt tttcccccac cctcccagct cacagaatac 34200 acagtccttt ccccccggct ggctttaaac aacactatct cattggtaac agacatattt 34260 ttaggtgtaa taatccacac ggtctcttgg cgggccaaac gctggtctgt gatgttaata 34320 aactccccag gcagctcttt caagttcacg tcgctgtcca actgctgaag cgctcgcggc 34380 tccgactgcg cctctagcgg aggcaacggc agcacccgat ccttgatcta taaaggagta 34440 gagtcataat cccccataag aatagggcgg tgatgcagca acaaggcgcg cagcaactcc 34500 tgccgccgcc tctccgtacg acaggaatgc aacggggtgg tggtctcctc cgcgataatc 34560 cgcaccgctc gcagcatcag catcctcgtc ctccgggcac agcagcgcat cctgatctca 34620 ctgagatcgg cgcagtaagt gcagcacaac accaagatgt tatttaagat cccacagtgc 34680 aaagcactgt acccaaagct catggcggga aggacagccc ccacgtgacc atcgtaccag 34740 atcctcaggt aaatcaaatg acgacctctc ataaacacgc tggacatata catcacctcc 34800 ttgggcatga gctgattcac cacctctcga taccacaggc atcgctgatt aattaaagac 34860 ccctcgagca ccatcctgaa ccaggaagcc agcacctgac cccccgccag gcactgcagg 34920 gaccccggtg aatcgcagtg gcagtgaaga ctccagcgct cgtagccgtg aaccatagag 34980 ctggtcatta tatccacatt ggcacaacac agacacactt tcatacactt tttcatgatt 35040 agcagctcct ctctagtcaa gaccatatcc caaggaatca cccactcttg aatcaaggta 35100 aatcccacac agcagggcag gcctctcaca taactcacgt tatgcatagt gagcgtgtcg 35160 caatctggaa ataccggatg atcttccatc accgaagccc gggtctccgt ctcaaaggga 35220 ggtaaacggt ccctcgtgta gggacagtgg cgggataatc gagatcgtgt tgaacgtaga 35280 gtcatgccaa agggaacagc ggacgtactc atatttcctc cagcagaacc aagtgcgcgc 35340 gtggcagcta tccctgcgtc ttctgtctcg ccgcctgccc cgctcggtgt agtagttgta 35400 atacagccac tccctcagac cgtcaaggcg ctccctggcg tccggatcta taacaacacc 35460 gtcctgcagc gccgccctga tgacatccac caccgtagag tatgccaagc ccagccacga 35520 aatgcactca ctttgacagc gagagatagg aggagcggga agagatggaa gaaccatgat 35580 agtaaaagaa cttttattcc aatcgatcct ctacaatgtc aaagtgtaga tctatcagat 35640 ggcactggtc tcctccgctg agtcgatcaa aaataacagc taaaccacaa acaacacgat 35700 tggtcaaatg ctgcacaagg gcttgcagca taaaatcgcc tcgaaagtcc accgcaagca 35760 taacatcaaa gccaccgccc ctatcatgat ctatgataaa aaccccacag ctatccacca 35820 gacccatata gttttcatct ctccatcgtg aaaaaatatt tacaagctcc tcctttaaat 35880 cacctccaac caattcaaaa agttgagcca gaccgccctc caccttcatt ttcagcatgc 35940 gcatcatgat tgcaaaaatt caggctcctc agacacctgt ataagattga gaagcggaac 36000 gttaacatca atgtttcgct cgcgaagatc gcgcctcagt gcaagcatga tataatccca 36060 caggtcggag cggatcagcg aggacatctc cccgccagga accaactcaa cggagcctat 36120 gctgattata atacgcatat tcggggctat gctaaccagc acggccccca aataggcgta 36180 ctgcataggc ggcgacaaaa agtgaacagt ttgggttaaa aaatcaggca aacactcgcg 36240 caaaaaagca agaacatcat aaccatgctc atgcaaatag atgcaagtaa gctcaggaac 36300 gaccacagaa aaatgcacaa tttttctctc aaacatgact gcgagccctg caaaaaataa 36360 aaaagaaaca ttacacaaga gtagcctgtc ttacaatggg atagactact ctaaccaaca 36420 taagacgggc cacgacatcg cccgcgtggc cataaaaaaa attatccgtg tgattaaaaa 36480 gaagcacaga tagctggcca gtcatatccg gagtcatcac gtgcgaaccc gtgtagaccc 36540 ccgggttgga cacatcggcc aaacaaagaa agcggccaat gtatcccgga ggaatgataa 36600 cactaagacg aagatacaac agaataaccc catggggggg aataacaaag ttagtaggtg 36660 aataaaaacg ataaacaccc gaaactccct cctgcgtagg caaaatagcg ccctcccctt 36720 ccaaaacaac atacagcgct tccacagcag ccatgacaaa agactcaaaa cactcaaaag 36780 actcagtctt accaggaaaa taaaagcact ctcacagcac cagcactaat cagagtgtga 36840 agagggccaa gtgccgaacg agtatatata ggaattaaaa atgacgtaaa tgtgtaaagg 36900 tcaaaaaacg cccagaaaaa tacacagacc aacgcccgaa acgaaaaccc gcgaaaaaat 36960 acccagaagt tcctcaacaa ccgccacttc cgctttccca cgatacgtca cttcctcaaa 37020 aatagcaaac tacatttccc acatgtacaa aaccaaaacc cctccccttg tcaccgccca 37080 caacttacat aatcacaaac gtcaaagcct acgtcacccg ccccgcctcg ccccgcccac 37140 ctcattatca tattggcctc aatccaaaat aaggtatatt attgatgatg 37190 <210> 10 <211> 37184 <212> DNA <213> Great Ape Adenovirus <400> 10 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg cggagggtat ttaaacccgc 480 tgcgctccta aagaggccac tcttgagtgc cagcgagaag agttttctcc tccgctccgt 540 ttcggcgatc gaaaaatgag acatttagcc tgcactccgg gtcttttgtc cggccgggcg 600 gcgtccgagc ttttggacgc tttgctcaat gaggttctga gcgatgattt tccgtctact 660 acccacttta gcccacctac tcttcacgaa ctgtacgatc tggatgtact ggtggatgtg 720 aacgatccca acgaggaggc ggtttctacg ttttttcccg agtctgcgct tttggctgcc 780 caggagggat ttgacctaca cactccgccg ctgcctattt tagagtctcc gctgccggag 840 cccagtggta taccttatat gcctgaactg cttcccgaag tggtagacct gacctgccac 900 gagccgggct ttccgcccag cgacgatgag ggtgagcctt ttgctttaga ctatgctgag 960 atacctgggc tcggttgcag gtcttgtgca tatcatcaga gggttaccgg agaccccgag 1020 gttaagtgtt cgctgtgcta tatgaggctg acctcttcct ttatctacag taagtttttt 1080 tgtgtaggtg ggctttttgg gtaggtgggt tttgtggcag gacaggtgta aatgttgctt 1140 gtgttttttg tacctgcagg tccggtgtcc gagccagacc cggagcccga ccgcgatccc 1200 gagccggatc ccgagcctcc tcgcaggcca aggaaattac cttccatttt gtgcaagcct 1260 aagacacctg tgaggaccag cgaggcggac agcactgact ctggcacttc tacctctcct 1320 cctgaaattc acccagtggt tcctctgggt atacatagac ctgttgctgt tagagtttgc 1380 gggcgacgcc ctgcagtaga gtgcattgag gacttgctta acgatcccga gggacctttg 1440 gacttgagca ttaaacgccc taggcaataa accccaccta agtaataaac cccacctaag 1500 taataaactt taccgccctt ggttattgag atgacgccca atgtttgctt ttgaatgact 1560 tcatgtgtat aataaaagtg agtgtggtca taggtctctt gtttgtctgg gcggggttta 1620 agggtatata agtttctcgg ggctaaactt ggttacactt gaccccaatg gaggcgtggg 1680 ggtgcttgga ggagtttgcg gacgtgcgcc gtttgctgga cgagagctct agcaatacct 1740 atagtatttg gaggtatctg tggggctcta ctcaggccaa gttggtcttc agaattaagc 1800 aggattacaa gtgcgatttt gaagagcttt ttagttcctg tggtgagctt ttgcaatcct 1860 tgaatctggg ccaccaggct atcttccagg aaaaggttct ctcgactttg gatttttcca 1920 ctcccgggcg caccgccgct tgtgtggctt ttgtgtcttt tgtgcaagat aaatggagcg 1980 gggagaccca cctgagtcac ggctacgtgc tggatttcat ggcgatggct ctttggaggg 2040 cttacaacaa atggaagatt cagaaggaac tgtacggttc cgccctacgt cgtccacttc 2100 tgcagcggca ggggctgatg tttcccgacc atcgccagca tcagaatctg gaagacgagc 2160 gagcggagaa gatcagcttg agagccggcc tggaccctcc tcaggaggaa tgaatctccc 2220 gcaggtggtt gagctgtttc ccgaactgag acgggtcctg actatcaggg aggatggtca 2280 gtttgtgaag aagctgaaga gggatcgggg tgagggagat gatgaggcgg ctagcaattt 2340 agcttttagt ctgataactc gccaccgacc ggaatgtatt acctatcagc agattaagga 2400 gagttgtgcc aacgagctgg atcttttggg tcagaagtat agcatagaac agcttaccac 2460 ttactggctt cagcccgggg atgattggga agaggcgatt agggtgtatg caaaggtggc 2520 cctgcggccc gattgcaagt ataagattac taagttggtt aatattagaa actgctgcta 2580 tatttctgga aacggggccg aagtggagat agatactgag gacagggtgg ctattaggtg 2640 ttgcatgata aacatgtggc ccgggatact ggggatggat ggggtgatat ttatgaatgt 2700 gaggttcacg ggccccaact ttaatggtac ggtgttcatg ggcaacacca acttgctcct 2760 gcatggtgcg agtttctatg ggtttaacaa cacctgtata gaggcctgga ccgatgtaaa 2820 ggttcgaggt tgttcctttt atagctgttg gaaggcggtg gtgtgtcgcc ctaaaagcag 2880 gggttctgtg aagaaatgct tgtttgaaag gtgcacccta ggtatccttt ctgagggcaa 2940 ctccagggtg cgccataatg tggcttcgaa ctgcggttgc ttcatgcaag tgaagggggt 3000 gagcgttatc aagcataact cggtctgtgg aaactgcgag gatcgcgcct ctcagatgct 3060 gacctgcttt gatggcaact gtcacctgtt gaagaccatt catataagca gtcaccccag 3120 aaaggcctgg cccgtgtttg agcataacat tctgacccgc tgttccttgc atctgggggt 3180 caggaggggt atgttcctgc cttaccagtg taactttagc cacactaaaa tcctgctgga 3240 acccgagtgc atgactaagg tcagcctgaa tggtgtgttt gatgtgagtc tgaagatttg 3300 gaaggtgctg aggtatgatg agaccaggac caggtgccga ccctgcgagt gcggcggcaa 3360 gcacatgaga aatcagcctg tgatgttgga tgtgaccgag gagcttaggc ctgaccatct 3420 ggtgctggcc tgcaccaggg ccgagtttgg gtctagcgat gaggataccg attgaggtgg 3480 gtaaggtggg cgtggctagc agggtgggcg tgtataaatt gggggtctaa ggggtctctc 3540 tgtttgtctt gcaacagccg ccgccatgag cgacaccggc aacagctttg atggaagcat 3600 ctttagtccc tatctgacag tgcgcatgcc tcactgggcc ggagtgcgtc agaatgtgat 3660 gggttccaac gtggatggac gtcccgttct gccttcaaat tcgtctacta tggcctacgc 3720 gaccgtggga ggaactccgc tggacgccgc gacctccgcc gccgcctccg ccgccgccgc 3780 gaccgcgcgc agcatggcta cggaccttta cagctctttg gtggcgagca gcgcggcctc 3840 tcgcgcgtct gctcgggatg agaaactgac tgctctgctg cttaaactgg aagacttgac 3900 ccgggagctg ggtcaactga cccagcaggt ttccagcttg cgtgagagca gccttgcctc 3960 cccctaatgg cccataatat aaataaaagc cagtctgttt ggattaagca agtgtatgtt 4020 ctttatttaa ctctccgcgc gcggtaagcc cgggaccagc ggtctcggtc gtttagggtg 4080 cggtggattt tttccaacac gtggtacagg tggctctgga tgtttagata catgggcatg 4140 agtccatccc tggggtggag gtagcaccac tgcagagctt cgtgctcggg ggtggtgttg 4200 tatatgatcc agtcgtagca ggagcgctgg gcgtggtgct gaaaaatgtc cttaagcaag 4260 aggcttatag ctagggggag gcccttggtg taagtgttta caaatctgct tagctgggag 4320 gggtgcatcc ggggggatat gatgtgcatc ttggactgga tttttaggtt ggctatgttc 4380 ccgcccagat cccttctggg attcatgttg tgcaggacca ccagcacggt atatccagtg 4440 cacttgggaa atttatcgtg gagcttagac gggaatgcat ggaagaactt ggagacgccc 4500 ttgtggcctc ccagattttc catacattcg tccatgatga tggcaatggg cccgtgggaa 4560 gctgcctgag caaaaacgtt tctggcatcg ctcacatcgt agttatgttc cagggtgagg 4620 tcatcatagg acatctttac gaatcggggg cgaagggtcc cggactgggg gatgatggta 4680 ccctcgggcc ccggggcgta gttcccctca cagatctgca tctcccaggc tttcatttca 4740 gagggaggga tcatatccac ctgcggggcg atgaaaaaga cagtttctgg cgcaggggag 4800 attaactggg atgagagcag gtttctgagc agctgtgact ttccacagcc ggtgggccca 4860 tatatcacgc ctatcaccgg ctgcagctgg tagttaagag agctgcagct gccgtcctcc 4920 cggagcaggg gggccacctc gttgagcata tccctgacgt ggatgttctc cctgaccagt 4980 tccgccagaa ggcgctcgcc gcccagcgaa agcagctctt gcaaggaagc aaaatttttc 5040 agcggtttca ggccatcggc cgtgggcatg tttttcagcg tctgggtcag cagctccagc 5100 ctgtcccaga gctcggtgat gtgctctacg gcatctcgat ccagcagatc tcctcgtttc 5160 gcgggttggg gcggctttcg ctgtagggca ccagccgatg ggcgtccagc ggggccagag 5220 tcatgtcctt ccatgggcgc agggtcctcg tcagggtggt ctgggtcacg gtgaaggggt 5280 gcgctccggg ttgggcactg gccagggtgc gcttgaggct ggttctgctg gtgctgaatc 5340 gctgccgctc ttcgccctgc gcgtcggcca ggtagcattt gaccatggtc tcgtagtcga 5400 gaccctcggc ggcgtgcccc ttggcgcgga gctttccctt ggaggtggcg ccgcacgagg 5460 ggcactgcag gctcttcagg gcgtagagct tgggagcgag aaacacggac tctggggagt 5520 aggcgtccgc gccgcaggcc gagcagaccg tctcgcattc caccagccaa gtgagttccg 5580 ggcggtcagg gtcaaaaacc aggttgcccc catgcttttt gatgcgtttc ttaccttggc 5640 tctccatgag gcggtgtccc ttctcggtga cgaagaggct gtccgtgtcc ccgtagaccg 5700 acttcagggg cctgtcttcc agcggagtgc ctctgtcctc ctcgtagaga aactctgacc 5760 actctgagac gaaggcccgc gtccaggcca ggacgaagga ggccacgtgg gaggggtagc 5820 ggtcgttgtc cactagcggg tccaccttct ccagggtgtg caggcacatg tccccctcct 5880 ccgcgtccag aaaagtgatt ggcttgtagg tgtaggacac gtgaccgggg gttcccaacg 5940 ggggggtata aaagggggtg ggtgcccttt catcttcact ctcttccgca tcgctgtctg 6000 cgagagccag ctgctggggt aagtattccc tctcgaaggc gggcatgacc tcagcgctca 6060 ggttgtcagt ttctaaaaat gaggaggatt tgatgttcac ctgtccggag gtgatacctt 6120 tgagggtacc tgggtccatc tggtcagaaa acactatttt tttgttatca agcttggtgg 6180 cgaatgaccc gtagagggcg ttggagagca gcttggcgat ggagcgcagg gtctggtttt 6240 tgtcgcggtc ggctcgctcc ttggccgcga tgttgagttg cacgtactcg cgggccacgc 6300 acttccactc ggggaacacg gtggtgcgct cgtctgggat caggcgcacc ctccagccgc 6360 ggttgtgcag ggtgaccatg tcgacgctgg tggcgacctc accgcgcaga cgctcgttgg 6420 tccagcagag gcggccgccc ttgcgcgagc agaagggggg tagggggtcc agctggtcct 6480 cgtttggggg gtccgcgtcg atggtaaaga ccccggggag caggcgcggg tcaaagtagt 6540 cgatcttgca agcttgcatg tccagagccc gctgccattc gcgggcggcg agcgcgcgct 6600 cgtaggggtt gaggggcggg ccccagggca tggggtgggt gagcgcggag gcgtacatgc 6660 cgcagatgtc atacacgtac aggggttccc tgaggatacc gaggtaggtg gggtagcagc 6720 gccccccgcg gatgctggcg cgcacgtagt catagagctc gtgggagggg gccagcatgt 6780 tgggcccgag gttggtgcgc tgggggcgct cggcgcggaa gacgatctgc ctgaagatgg 6840 cgtgggagtt ggaggagatg gtgggccgct ggaagacgtt gaagcttgct tcttgcaagc 6900 ccacggagtc cctgacgaag gaggcgtagg actcgcgcag cttgtgcacc agctcggcgg 6960 tgacctggac gtcgagcgca cagtagtcga gggtctcgcg gatgatgtca tacctatcct 7020 cccccttctt tttccacagc tcgcggttga ggacgaactc ttcgcggtct ttccagtact 7080 cttggagggg aaacccgtcc gtgtccgaac ggtaagagcc tagcatgtag aactggttga 7140 cggcctggta ggggcagcag cccttctcca cgggcagcgc gtaggcctgc gccgccttgc 7200 ggagggaggt gtgggtgagg gcgaaagtgt ccctgaccat gactttgagg tattgatgtc 7260 tgaagtctgt gtcatcgcag ccgccctgtt cccacagggt gtagtccgtg cgctttttgg 7320 agcgcgggtt gggcagggag aaggtgaggt cattgaagag gatcttcccc gctcgaggca 7380 tgaagtttct ggtgatgcga aagggccctg ggaccgagga gcggttgttg atgacctggg 7440 cggccaggac gatctcgtca aagccgttta tgttgtgtcc cacgatgtag agctccagga 7500 agcggggctg gcccttgatg gaggggagct ttttaagttc ctcgtaggta agctcctcgg 7560 gcgattccag gccgtgctcc tccagggccc agtcttgcaa gtgagggttg gccgccagga 7620 aggatcgcca gaggtcgcgg gccatgaggg tctgcaggcg gtcgcggaag gttctgaact 7680 gccgccccac ggccattttt tcgggggtga tgcagtagaa ggtgaggggg tctttctccc 7740 aggggtccca tctgagctct cgggcgaggt cgcgcgcggc agcgaccaga gcctcgtcgc 7800 cccccagttt catgaccagc atgaagggca cgagttgctt gccaaaggct cccatccaag 7860 tgtaggtttc tacatcgtag gtgacaaaga ggcgctccgt gcgaggatga gagccgattg 7920 ggaagaactg gatctcccgc caccagttgg aggattggct gttgatgtgg tgaaagtaga 7980 agtcccgtct gcgggccgag cactcgtgct ggcttttgta aaagcgaccg cagtactggc 8040 agcgctgcac gggttgtata tcttgcacga ggtgaacctg gcgacctctg acgaggaagc 8100 gcagcgggaa tctaagtccc ccgcctgggg tcccgtgtgg ctggtggtct tttactttgg 8160 ttgtctggcc gccagcatct gtctcctgga gggcgatggt ggaacagacc accacgccgc 8220 gagagccgca ggtccagatc tcggcgctcg gcgggcggag tttgatgacg acatcgcgca 8280 cattggagct gtccatggtc tccagctccc gcggcggcag gtcagccggg agttcctgga 8340 ggttcacctc gcagagacgg gtcaaggcgc ggacagtgtt gagatggtat ctgatttcaa 8400 ggggcatgtt ggaggcggag tcgatggctt gcaggaggcc gcagccccgg ggggccacga 8460 tggttccccg cggggcgcga ggggaggcgg aagctggggg tgtgttcaga agcggtgacg 8520 cgggcgggcc cccggaggta gggggggttc cggccccaca ggcatgggcg gcaggggcac 8580 gtcttcgccg cgcgcgggca ggggctggtg ctggctccga agagcgcttg cgtgcgcgac 8640 gacgcgacgg ttggtgtcct gtatctggcg cctctgagtg aagaccacgg gtcccgtgac 8700 cttgaacctg aaagagagtt cgacagaatc aatctcggca tcgttgacag cggcctggcg 8760 caggatctcc tgcacgtcgc ccgagttgtc ctggtaggcg atttctgcca tgaactgctc 8820 gatctcttcc tcctggagat ctcctcgtcc ggcgcgctcc acggtggccg ccaggtcgtt 8880 ggagatgcga cccatgagct gcgagaaggc gttgagtccg ccctcgttcc agacccggct 8940 gtagaccacg cccccctcgg cgtcgcgggc gcgcatgacc acctgggcca ggttgagctc 9000 cacgtgtcgc gtgaagacgg cgtagttgcg caggcgctgg aaaaggtagt tcagggtggt 9060 ggcggtgtgc tcggcgacga agaagtacat gacccagcgc cgcaacgtgg attcattgat 9120 gtcccccaag gcctccaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9180 ctgggagttg cgagcggaca cggtcaactc ctcctccaga agacggatga gctcggcgac 9240 agtgtcgcgc acctcgcgct cgaaggccac ggggggcgct tcttcctctt ccacctcttc 9300 ttccatgatt gcttcttctt cttcctcagc cgggacggga gggggcggcg gcgggggagg 9360 ggcgcggcgg cggcggcggc gcaccgggag gcggtcgatg aagcgctcga tcatctcccc 9420 ccgcatgcgg cgcatggtct cggtgacggc gcggccgttc tcccgggggc gcagctcgaa 9480 gacgccgcct ctcatttcgc cgcggggcgg gcggccgtga ggtagcgaga cggcgctgac 9540 tatgcatctt aacaattgct gtgtaggtac gccgccaagg gacctgattg agtccagatc 9600 caccggatcc gaaaaccttt ggaggaaagc gtctatccag tcgcagtcgc aaggtaggct 9660 gagcaccgtg gcgggcgggg gcgggtcggg agagttcctg gcggagatgc tgctgatgat 9720 gtaattaaag taggcggtct tgagaaggcg gatggtggac aggagcacca tgtctttggg 9780 tccggcctgt tggatgcgga ggcggtcggc catgccccag gcctcgttct gacaccggcg 9840 caggtctttg tagtaatctt gcatgagtct ttccaccggc acttcttctc cttcctcttc 9900 ttcatctcgc cggtggtttc tcgcgccgcc catgcgcgtg accccaaagc ccctgagcgg 9960 ctgcagcagg gccaggtcgg cgaccacgcg ctcggccaag atggcctgct gtacctgagt 10020 gagggtcctc tcgaagtcat ccatgtccac gaagcggtgg taggcacccg tgttgatggt 10080 gtaggtgcag ttggccatga cggaccagtt gacggtctgg tgtcccggct gcgagagctc 10140 cgtgtaccgc aggcgcgaga aggcgcggga atcgaacacg tagtcgttgc aagtccgcac 10200 cagatactgg tagcccacca ggaagtgcgg cggaggttgg cgatagaggg gccagcgctg 10260 ggtggcgggg gcgccgggcg ccaggtcttc cagcatgagg cggtggtatc cgtagatgta 10320 cctggacatc caggtgatgc ctgcggcggt ggtggtggcg cgcgcgtagt cgcggacccg 10380 gttccagatg tttcgcaggg gcgagaagtg ttccatggtc ggcacgctct ggccggtgag 10440 gcgcgcgcag tcgttgacgc tctatacaca cacaaaaacg aaagcgttta cagggctttc 10500 gttctgtagc ctggaggaaa gtaaatgggt tgggttgcgg tgtgccccgg ttcgagacca 10560 agctgagctc agccggctga agccgcagct aacgtggtat tggcagtccc gtctcgaccc 10620 aggccctgta tcctccagga tacggtcgag agcccttttg ctttcttggc caagcgcccg 10680 tggcgcgatc tgggatagat ggtcgcgatg agaggacaaa agcggctcgc ttccgtagtc 10740 tggagaaaca atcgccaggg ttgcgttgcg gcgtaccccg gttcgagccc ctatggcggc 10800 ttggatcggc cggaaccgcg gctaacgtgg gctgtggcag ccccgtcctc aggaccccgc 10860 cagccgactt ctccagttac gggagcgagc cccttttgtt tttttatttt ttagatgcat 10920 cccgtgctgc ggcagatgcg cccctcgccc cggcccgatc agcagcagca acagcaggca 10980 tgcagacccc cctctcctct ccccgccccg gtcaccacgg ccgcggcggc cgtgtccggt 11040 gcggggggcg cgctggagtc agatgagcca ccgcggcggc gacctaggca gtatctggac 11100 ttggaagagg gcgagggact ggcgcggctg ggggcgagct ctccagagcg ccacccgcgg 11160 gtgcagttga aaagggacgc gcgtgaggcg tacctgccgc ggcaaaacct gtttcgcgac 11220 cgcgggggcg aggagcccga ggagatgcgg gactgcaggt tccaagcggg gcgcgagctg 11280 cgccgcggct tggacagaca gcgcctgctg cgcgaggagg actttgagcc cgacacgcag 11340 acgggcatca gccccgcgcg cgcgcacgtg gccgcggccg acctggtgac cgcctacgag 11400 cagacggtga accaggagcg caacttccaa aaaagcttca acaaccacgt gcgcacgctg 11460 gtggcgcgcg aggaggtgac cctgggtctc atgcatctgt gggacctggt ggaggcgatc 11520 gtgcagaacc ccagcagcaa gcccctgacc gcgcagctgt tcctggtggt gcagcacagc 11580 agggacaacg aggccttcag ggaggcgctg ctgaacatca ccgagccgga ggggcgctgg 11640 ctcctggacc tgataaacat cctgcagagc atagtggtgc aggagcgcag cctgagcctg 11700 gccgagaagg tggcggccat taactattct atgctgagcc tgggcaagtt ctacgctcgc 11760 aagatctaca agacccccta cgtgcccata gacaaggagg tgaagataga cagcttctac 11820 atgcgcatgg cgctgaaggt gctaaccctg agcgacgacc tgggagtgta ccgcaacgag 11880 cgcatccaca aggccgtgag cgccagccgg cggcgcgagc tgagcgaccg cgaactgatg 11940 cacagtctgc agcgcgcgct gaccggcgcg ggcgagggcg acagggaggt cgagtcctac 12000 tttgacatgg gggccgacct gcactggcag ccgagccgcc gcgccctgga agcggcgggg 12060 gcgtacggcg gccccctggc ggccgatgac gaggaagagg aggactatga gctagaggag 12120 ggcgagtacc tggaggactg acctggctgg tggtgttttg gtatagatgc aagatccgaa 12180 cgtggcggac ccggcggtcc gggcggcgct gcagagccag ccgtccggca ttaactcctc 12240 tgacgactgg gccgcggcca tgggtcgcat catggccctg accgcgcgca accccgaggc 12300 cttcaggcag cagcctcagg ctaaccggct ggcggccatc ttggaagcgg tagtgcccgc 12360 gcgctccaac cccacccacg agaaggtgct ggccatagtc aacgcgctgg cggagagcag 12420 ggccatccgg gcagacgagg ccggactggt gtacgatgcg ctgctgcagc gggtggcgcg 12480 gtacaacagc ggcaacgtgc agaccaacct ggaccgcctg gtgacggacg tgcgcgaggc 12540 cgtggcgcag cgcgagcgct tgcatcagga cggcaacctg ggctcgctgg tggcgctaaa 12600 cgccttcctt agcacccagc cggccaacgt accgcggggg caggaggact acaccaactt 12660 cttgagcgcg ctgcggctga tggtgaccga ggtccctcag agcgaggtgt accagtcggg 12720 gcccgactac ttcttccaga ccagcagaca gggcttgcaa accgtgaacc tgagccaggc 12780 tttcaagaac ctgcgggggc tgtggggagt gaaggcgccc accggcgacc gggctacggt 12840 gtccagcctg ctaaccccca actcgcgcct gctgctgctg ctgatcgcgc ccttcacgga 12900 cagcgggagc gtctcgcggg agacctatct gggccacctg ctgacgctgt accgcgaggc 12960 catcgggcag gcgcaggtgg acgagcacac cttccaggag atcaccagcg tgagccacgc 13020 gctggggcag gaggacacgg gcagcctgca ggcgaccctg aactacctgc tgaccaacag 13080 gcggcagaag attcccacgc tgcacagcct gacccaggag gaggagcgca tcttgcgcta 13140 cgtgcagcag agcgtgagcc tgaacctgat gcgcgacggc gtgacgccca gcgtggcgct 13200 ggacatgacc gcgcgcaaca tggaaccggg catgtacgct tcccagcggc cgttcatcaa 13260 ccgcctgatg gactacttgc atcgggcggc ggccgtgaac cccgagtact tcaccaatgc 13320 cattctgaat ccccactgga tgccccctcc gggtttctac aacggggact tcgaggtgcc 13380 tgaggtcaac gatgggttcc tctgggatga catggatgac agtgtgttct cccccaaccc 13440 gctgcgcgcc gcgtctctgc gattgaagga gggctctgac agggaaggac caaggagtct 13500 ggcctcctcc ctggctctgg gggcggtggg cgccacgggc gcggcggcgc ggggcagcag 13560 ccccttcccc agcctggcgg actctctgaa tagcgggcgg gtgagcaggc cccgcttgct 13620 aggcgaggag gagtatctga acaactccct gctgcagccc gtgagggaca aaaacgctca 13680 gcggcagcag tttcccaaca atgggataga gagcctggtg gacaagatgt ccagatggaa 13740 gacgtatgcg caggagtaca aggagtggga ggaccgccag ccgcggcccc tgccgccccc 13800 tagacagcgc tggcagcggc gcgcgtccaa ccgccgctgg aggcaggggc ccgaggacga 13860 tgatgactct gcagatgaca gcagcgtgtt ggacctgggc gggagcggga accccttttc 13920 gcacctgcgc ccacgcctgg gcaagatgtt ttaaaagaga aaaataaaaa ctcaccaagg 13980 ccatggcgac gagcgttggt tttttgttcc cttccttagt atgcggcgcg cggcgatgtt 14040 cgaggagggg cctcccccct cttacgagag cgcgatggga atttctcctg cggcgcccct 14100 gcagcctccc tacgtgcctc ctcggtacct gcaacctaca ggggggagaa atagcatctg 14160 ttactctgag ctgcagcccc tgtacgatac caccagactg tacctggtgg acaacaagtc 14220 cgcggacgtg gcctccctga actaccagaa cgaccacagc gattttttga ccacggtgat 14280 ccaaaacaac gacttcaccc caaccgaggc cagtacccag accataaacc tggacaacag 14340 gtcgaactgg ggcggcgacc tgaagactat cctgcacacc aatatgccca acgtgaacga 14400 gttcatgttc accaactctt ttaaggcgcg ggtgatggtg gcgcgcgagc agggggaggc 14460 gaagtacgag tgggtggact tcacgctgcc cgagggcaac tactcagaga ccatgactct 14520 cgacctgatg aacaatgcga tcgtggaaca ctatctgaaa gtgggcaggc agaacggggt 14580 gaaggagagc gatatcgggg tcaagtttga caccagaaac ttccgtctgg gctgggaccc 14640 tgtgaccggg ctggtcatgc cgggggtcta caccaacgag gcctttcatc ccgatatagt 14700 gctcctgccc ggctgtgggg tggacttcac ccagagccgg ctgagcaacc tgctgggcgt 14760 tcgcaagcgg caacctttcc aggagggttt caagatcacc tatgaggatc tggagggggg 14820 caacattccc gcgctccttg atctggacgc ctacgaggag agcttgaaac ccgaggagag 14880 cgctggcgac agcggcgaga gtggcgagga gcaagccggc ggcggcggca gcgcgtcggt 14940 agaaaacgaa agtactcccg cagtggcggc ggacgctgcg gaggtcgagc cggaggccat 15000 gcagcaggac gcagaggagg gcgcgcagga ggacatgaac aatggggaga tcaggggcga 15060 cactttcgcc acccggggcg aagaaaaaga ggcagaggcg gcggcggcga cggcggaagc 15120 cgaaaccgag gcagaggcag agcccgagac cgaagttatg gaagacatga atgatggaga 15180 acgtaggggt gacacgtttg ccacccgggg cgaagagaag gcggcggagg cagaagccgc 15240 ggctgaggag gcggctgcgg ctgcggccaa ggctgaggct gcggctgagg ctaaggtcga 15300 agccgatgtt gcggttgagg ctcaggctga ggaggaggcg gcggctgaag cagttaagga 15360 aaaggcccag gcagagcagg aagagaaaaa acctgtcatt caacctctaa aagaagatag 15420 caaaaagcgc agttacaacg tcattgaggg cagcaccttt acccaatacc gcagctggta 15480 cctggcttac aactacggcg acccggtcaa gggggtgcgc tcgtggaccc tgctctgcac 15540 gccggacgtc acctgcggct ccgagcagat gtactggtcg ctgccaaaca tgatgcaaga 15600 cccggtgacc ttccgttcca cgcggcaggt tagcaacttt ccggtggtgg gcgccgaact 15660 gctgccagta cactccaaga gtttttacaa cgagcaggcc gtctactccc agctgatccg 15720 ccaggccacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 15780 cccgccggcc cccaccatca ccaccgtcag tgaaaacgtt cctgccctca cagatcacgg 15840 gacgctaccg ctgcgcaaca gcatctcagg agtccagcga gtgaccatta ctgacgccag 15900 acgccggacc tgcccctacg tttacaaggc cttgggcata gtctcgccgc gcgtcctctc 15960 cagtcgcact ttttaaaaca catccaccca cacgctccaa aatcatgtcc gtactcatct 16020 cgcccagcaa caacaccggc tgggggctgc gcgcacccag caagatgttt ggaggggcaa 16080 ggaagcgctc cgaccagcac cccgtgcgcg tgcgcggcca ctaccgcgcg ccctggggtg 16140 cgcacaagcg cgggcgcaca gggcgcacca ctgtggatga tgtcattgac tccgtagtgg 16200 agcaggcgcg ccactacaca cccggcgcgc cgaccgcctc cgccgtgtcc accgtggacc 16260 aggcgatcga aagcgtggta cagggggcgc ggcactatgc caaccttaaa agtcgccgcc 16320 gccgcgtggc gcgccgccat cgccggagac cccgggctac tgccgccgcg cgccttacca 16380 aggctctgct caagcgcgcc aggcgaactg gccaccgggc cgccatgagg gccgcacggc 16440 gggctgccgc tgccgcgagc gccgtggccc cgcgggcacg aaggcgcgcg gccgctgccg 16500 ccgccgccgc catttccagc ttggcctcga cgcggcgcgg taacatatac tgggtgcgcg 16560 actcggtgag cggcacacgt gtgcccgtgc gctttcgccc cccacggaat tagcacaaga 16620 caacatacac actgagtctc ctgctgttgt gtatcccagc ggcgaccgtc agcagcggcg 16680 acatgtccaa gcgcaaaatt aaagaagaga tgctccaggt catcgcgccg gagatctatg 16740 ggcccccgaa gaaggaggag gaggattaca agccccgcaa gctaaagcgg gtcaaaaaga 16800 aaaagaaaga tgatgacgtt gacgaggcgg tggagtttgt ccgccgcatg gcgcccaggc 16860 gccctgtgca gtggaagggt cggcgcgtgc agcgagtcct gcgccccggc accgcggtgg 16920 tctttacgcc cggcgagcgt tccacgcgca ctttcaagcg ggtgtacgat gaggtgtacg 16980 gcgacgagga tctgttggag caggccaacc atcgatttgg ggagtttgca tatgggaaac 17040 ggcctcgcga gagtctaaaa gaggacctgc tggcgctacc gctggacgag ggcaatccca 17100 ccccgagtct gaagccggtg accctgcaac aggtgctgcc tttgagcgcg cccagcgagc 17160 agaagcgagg gttaaagcgc gagggcgggg acctggcacc caccgtgcag ttgatggtgc 17220 ccaagcggca gaagctggag gacgtgctgg agaaaatgaa agtagagccc gggatccagc 17280 ccgagatcaa ggtccgccct atcaagcagg tggcgcccgg cgtgggagtc cagaccgtgg 17340 acgttaggat tcccacggag gagatggaaa cccaaaccgc cactccctct tcggcagcaa 17400 gcgccaccac cggcgccgct tcggtagagg tgcagacgga cccctggcta cccgccgcca 17460 ctatcgccgt cgccgccgcc ccccgttcgc gcggacgcaa gagaaattat ccagcggcca 17520 gcgcgcttat gccccagtat gcgctgcatc catccatcgc gcccaccccc ggctaccgcg 17580 ggtactcgta ccgcccgcgc agatcagccg gcactcgcgg ccgccgccgc cgtgcgacca 17640 caaccagccg ccgccgtcgc cgccgccgcc agccagtgct gacccccgtg tctgtaagga 17700 aggtggctcg ctcggggagc acgctggtgg tgcccagagc gcgctaccac cccagcatcg 17760 tttaaagccg gtctctgtat ggttcttgca gatatggccc tcacttgtcg ccttcgcttc 17820 ccggtgccgg gataccgagg aagaactcac cgccgcaggg gcatggcggg cagcggtctc 17880 cgcggcggcc gtcgccatcg ccggcgcgca aagagcaggc gcatgcgcgg cggtgtgttg 17940 cccctgctgg tcccgctact cgccgcggcg atcggcgccg tgcccgggat cgcctccgtg 18000 gccctgcagg cgtcccagaa acattgactc ttgcaacctt gcaagcttgc atttttggag 18060 gaaaaaataa aaaagtctag actctcacgc tcgcttggtc ctgtgactat tttgtagaaa 18120 aaagatggaa gacatcaact ttgcgtcgct ggccccgcgt cacggctcgc gcccgttcat 18180 gggagactgg acagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggcag 18240 tctgtggagc ggccttaaaa attttggttc caccattaag aactatggca acaaagcgtg 18300 gaacagcagc acgggtcaga tgctgagaga caagttgaaa gagcagaact tccaggagaa 18360 ggtggcgcag ggcctggcct ctggcatcag cggggtggtg gacatagcta accaggccgt 18420 gcagaaaaag ataaacagtc atctggaccc ccgccctcag gtggaggaaa cgcctccagc 18480 catggagacg gtgtctcccg agggcaaagg cgaaaagcgc ccgcggcccg acagggaaga 18540 gaccctggtg tcacacaccg aggagccgcc ctcttacgag gaggcagtca aggccggcct 18600 gcccaccact cgccccatag ctcccatggc caccggtgtg gtgggtcaca ggcaacacac 18660 ccccgcaaca ctagatctgc ccccgccgtc cgagccgact cgccagccaa aggcggtgac 18720 ggtgtccgct ccctccactt ccgccgccaa cagagtgcct ctgcgccgcg ctgcgagcgg 18780 cccccgggcc tcgcgagtca gcggcaactg gcagagcaca ctgaacagca tcgtgggcct 18840 gggagtgagg agtgtgaagc gccgccgttg ctactgaatg agcaagctag ctaacgtgtt 18900 gtatgtgtgt atgcgtccta tgtcgccgcc agaggagctg ttgagccgcc ggcgccgtct 18960 gcactccagc gaatttcaag atggcgaccc catcgatgat gcctcagtgg tcgtacatgc 19020 acatctcggg ccaggacgct tcggagtacc tgagccccgg gctggtgcag ttcgcccgcg 19080 ccacagacac ctacttcaac atgagtaaca agttcaggaa ccccactgtg gcgcccaccc 19140 acgatgtgac cacggaccgg tcgcagcgcc tgacgctgcg gttcatcccc gtggatcggg 19200 aggacaccgc ttactcttac aaggcgcggt tcacgctggc cgtgggcgac aaccgcgtgc 19260 tggacatggc ctccacttac tttgacatcc ggggggtgct ggacaggggc cccactttta 19320 agccctactc gggcactgcc tacaaccccc tggcccccaa gggcgccccc aattcttgtg 19380 agtgggaaca agaggaaaat caggtggtcg ctgcagatga tgaacttgaa gatgaagaag 19440 cgcaagcaca agaggaagcc cctgtgaaaa aaattcatgt atatgctcag gcgcctcttt 19500 ctggcgaaaa gattaccaag gatggtttgc aaataggtac tgaagtcgta ggagatacat 19560 ctaaggacac ttttgcagat aaaacattcc aacccgaacc tcagataggc gagtctcagt 19620 ggaacgaggc tgatgccaca gtagcaggag gtagagtttt gaaaaagact acccctatga 19680 gaccttgcta tggatcctat gccaggccta ccaatgccaa cgggggtcaa ggaattatgg 19740 ttgccaatga acaaggagtg ttggagtcta aagtagaaat gcaatttttc tctaacacca 19800 caacccttaa tgcgcgggat ggaaccggca atcccgaacc aaaggtggtg ttgtacagcg 19860 aagatgtcca cttggaatct cccgatactc atctgtctta caagcccaaa aaggatgatg 19920 ttaatgccaa aatcatgttg ggtcagcaag ccatgcccaa cagacccaac ctcattggat 19980 ttagagataa tttcattggg cttatgtttt acaacagcac cggtaacatg ggagtgctgg 20040 cgggtcaggc ctctcagttg aatgctgtgg tggacttgca ggatagaaac acagaactgt 20100 catatcagct tatgcttgat tcaattgggg atagaaccag atacttctcc atgtggaacc 20160 aggcagtgga tagctatgat ccagatgtca gaattattga aaaccatggg actgaggatg 20220 aactgcccaa ctactgcttc cctttgggcg gcataggagt tactgatact tatcaaggga 20280 taaaaaatac caatggcaat ggtcagtgga ccaaagatga tcagttcgcg gaccgcaacg 20340 aaataggggt gggaaacaac ttcgccatgg agatcaacat ccaggccaac ctttggagaa 20400 acttcctcta tgcaaacgtg gggctctacc tgccagacaa gctcaagtac aaccccacca 20460 acgtggacat ctctgacaac cccaacacct atgactacat gaacaagcgg gtggtggccc 20520 ctggcctggt ggactgcttt gtcaatgtgg gagccaggtg gtccctggac tacatggaca 20580 acgtcaaccc cttcaaccac caccgcaatg cgggtctgcg ctaccgctcc atgatcctgg 20640 gcaacgggcg ctatgtgccc tttcacatcc aggtacccca gaagttcttt gccatcaaga 20700 acctcctgct cctgcccggc tcctacacct acgagtggaa cttcaggaag gatgtgaaca 20760 tggtcctaca gagctctctg ggcaatgacc ttagggtgga tggggccagc atcaagtttg 20820 acagcatcac cctctatgct acatttttcc ccatggccca caacaccgcc tccacgcttg 20880 aggccatgct gagaaacgac accaacgacc agtcctttaa tgactacctc tctggggcca 20940 acatgctcta cccaatccca gccaaggcca ccaacgtgcc catctccatc ccctctcgca 21000 actgggccgc ctttagaggc tgggccttta cccgccttaa gaccaaggag accccctccc 21060 tgggctcggg ttttgatccc tactttgttt actcgggatc catcccctac ctggatggca 21120 ccttctacct caaccacact ttcaagaaga tatccatcat gtatgactcc tccgtcagct 21180 ggccgggcaa cgaccgcttg ctcaccccca atgagttcga ggtcaagcgc gccgtggacg 21240 gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtgcagatgc 21300 tggccaacta caacataggc taccagggct tttacatccc agagagctac aaggacagga 21360 tgtactcctt cttcagaaat ttccaaccca tgagccgaca ggtggtggac gagaccaatt 21420 acaaggacta tcaagccatt ggcatcaccc accagcacaa caactcgggt ttcgtgggct 21480 acctggcgcc caccatgcgc gagggtcagg cctaccccgc caacttcccc taccccttga 21540 taggcaagac cgcggtcgac agcgtcaccc agaaaaagtt cctctgcgac cgcaccctct 21600 ggcgcatccc cttctctagc aacttcatgt ccatgggtgc gctcacggac ctgggccaaa 21660 acctgcttta tgccaactct gcccatgcgc tggacatgac ttttgaggtg gaccccatgg 21720 acgagcccac ccttctctat attgtgtttg aagtgttcga cgtggtcaga gtgcaccagc 21780 cgcaccgcgg tgtcatcgag accgtgtacc tgcgtacgcc cttctcagcc ggcaacgcca 21840 ccacctaagg agacagcgcc gccgccgcct gcatgacggg ttccaccgag caagagctca 21900 gggccattgc cagagacctg ggatgcggac cctatttttt gggcacctat gacaaacgct 21960 tcccgggctt tatctcccga gacaagctcg cctgcgccat tgtcaacacg gccgcgcgcg 22020 agaccggggg cgtgcactgg ctggcctttg gctgggaccc gcgctccaaa acttgctacc 22080 tctttgaccc ctttggcttc tccgatcagc gcctcaggca gatttatgag tttgagtacg 22140 aggggctgct gcgccgcagc gcgctcgcct cctcgcccga ccgctgcatc acccttgaga 22200 agtccaccga aaccgtgcag gggccccact cggccgcctg cggtctcttc tgttgcatgt 22260 ttttgcacgc ctttgtgcac tggcctcaga gtcccatgga ttgcaacccc accatgaact 22320 tgctaaaggg agtgcccaac gccatgctcc agagccccca ggtccagccc accctgcgcc 22380 gcaaccagga acagctttac cgcttcctgg agcgccactc cccctacttc cgcagccaca 22440 gcgcgcgcat ccggggggcc acctcttttt gccacttgca agaaaacatg caagacggaa 22500 aatgatgtac agcatgcttt taataaatgt aaagactgtg cactttaatt atacacgggc 22560 tctttctggt tatttattca acaccgccgt cgccatttag aaatcgaaag ggttctgccg 22620 tgcgtcgccg tgcgccacgg gcagagacac gttgcgatac tggaagcggc tcgcccactt 22680 gaactcgggc accaccatgc ggggcagtgg ttcctcgggg aagttctcgc tccacagggt 22740 gcgggtcagc tgcagcgcgc tcaggaggtc gggagccgag atcttgaagt cgcagttggg 22800 gccggaaccc tgcgcgcgcg agttgcggta cacggggttg cagcactgga acaccagcag 22860 ggccggatta ttcacgctgg ccagcaggct ctcgtcgctg atcatgtcgc tgtccagatc 22920 ctccgcgttg ctcagggcga atggggtcat cttgcagacc tgcctgccca ggaaaggcgg 22980 gagcccaggc ttgccgttgc agtcgcagcg caggggcatt agcaggtgcc cacggcccga 23040 ctgcgcctgc gggtacaacg cgcgcatgaa ggcttcgatc tgcctaaaag ccacctgggt 23100 cttggctccc tccgaaaaga acatcccaca ggacttgctg gagaactggt tcgcgggaca 23160 gctggcatcg tgcaggcagc agcgcgcgtc agtgttggca atctgcacca cgttgcgacc 23220 ccaccggttt ttcactatct tggccttgga agcctgctcc tttagcgcgc gctggccgtt 23280 ctcgctggtc acatccatct ctatcacctg ttccttgttg atcatgtttg tcccgtgcag 23340 acactttagg tcgccctccg tctgggtgca gcggtgctcc cacagcgcgc aaccggtggg 23400 ctcccaattc ttgtgggtca cccccgcgta ggcctgcagg taggcctgca ggaagcgccc 23460 catcatggtc ataaaggtct tctggctcgt aaaggtcagc tgcaggccgc gatgctcttc 23520 gttcagccag gtcttgcaga tggcggccag cgcctcggtc tgctcgggca gcatcttaaa 23580 atttgtcttc aggtcgttat ccacgtggta cttgtccatc atggcacgcg ccgcctccat 23640 gcccttctcc caggcggaca ccatgggcag gcttaggggg tttatcactt ccagcggcga 23700 ggacaccgta ctttcgattt cttcttcctc cccctcttcc cggcgcgcgc ccccgctgtt 23760 gcgcgctctt accgcctgca ccaaggggtc gtcttcaggc aagcgccgca ccgagcgctt 23820 gccgcccttg acctgcttga tcagtaccgg cgggttgctg aagcccacca tggtcagcgc 23880 cgcctgctct tcttcgtctt cgctgtctac cactatttct ggggaggggc ttctccgctc 23940 tgcggcaaag gcggcggatc gcttcttttt tttcttggga gccgccgcga tggagtccgc 24000 cacggcgacc gaggtcgagg gcgtggggct gggggtgcgc ggtaccaggg cctcgtcgcc 24060 ctcggactct tcctctgact ccaggcggcg gcggagtcgc ttctttgggg gcgcgcgcgt 24120 cagcggcggc ggagacgggg acggggacgg ggacgggacg ccctccacag ggggtggtct 24180 tcgcgcagac ccgcggccgc gctcgggggt cttctcgcgc tggtcttggt cccgactggc 24240 cattgtatcc tcctcctcct aggcagagag acataaggag tctatcatgc aagtcgagaa 24300 ggaggagagc ttaaccaccc cctcagagac cgccgatgcg cccgccgtcg ccgtcgcccc 24360 cgctaccgcc gacgcgcccg ccacaccgag cgacaccccc acggaccccc ccgccgacgc 24420 acccctgttc gaggaagcgg ccgtggagca ggacccgggc tttgtctcgg cagaggagga 24480 tttgcaagag gaggagaata aggaggagaa gccctcagtg ccaaaagatc ataaagagca 24540 agacgagcac gacgcagacg cacaccaggg tgaagtcggg cggggggacg gagggcatgg 24600 cggcgccgac tacctagacg aaggaaacga cgtgctcttg aagcacctgc atcgtcagtg 24660 cgccatcgtc tgcgacgctc tgcaggagcg cagcgaggtg cccctcagcg tggcggaggt 24720 cagccgcgcc tacgagctca gcctcttttc cccccgggtg cccccccgcc gccgcgaaaa 24780 cggcacatgc gagcccaacc cgcgcctcaa cttctacccc gcctttgtgg tgcccgaggt 24840 cctggccacc tatcacatct tctttcaaaa ttgcaagatc cccatctcgt gccgcgccaa 24900 ccgtagccgc gccgataaga tgctggccct gcgccagggc gaccacatac ctgatatcgc 24960 cgctttggaa gatgtgccaa agatcttcga gggtctgggg cgcaacgaga agcgggcagc 25020 aaactctctg caacaggaaa acagcgaaaa tgagagtcac actggagcgc tggtggagct 25080 ggagggcgac aacgcccgcc tggcggtgct caagcgcagc atcgaggtca cccactttgc 25140 ctaccccgcg ctcaacctgc cccccaaagt catgaacgcg gtcatggacg ggctgatcat 25200 gcgccgcggc cggcccctcg ctccagatgc aaacttgcat gaggagaccg aggacggtca 25260 gcccgtggtc agcgacgagc agctgacgcg ctggctggag agcgcggacc ccgccgaact 25320 ggaggagcgg cgcaagatga tgatggccgc ggtgctggtc accgtagagc tggagtgtct 25380 gcagcgcttc ttcggtgacc ccgagatgca gagaaaggtc gaggagaccc tacactacac 25440 cttccgccag ggctacgtgc gccaggcttg caagatctcc aacgtggagc tcagcaacct 25500 ggtgtcctac ctgggcatct tgcatgaaaa ccgccttggg cagagcgtgc tacactccac 25560 cctgcgcggg gaggcgcgcc gcgactacgt gcgcgactgc gtttacctct tcctctgcta 25620 cacctggcag acggccatgg gggtctggca gcagtgcctg gaggagcgca acctcaagga 25680 gctggagaag cttctgcagc gcgcgctcaa agacctctgg acgggcttca acgagcgctc 25740 ggtggccgcc gcgctagccg acctcatctt ccccgagcgc ctgctcaaaa ccctccagca 25800 ggggctgccc gacttcacca gccaaagcat gttgcaaaat tttaggaact ttatcctgga 25860 gcgttctggc atcctacccg ccacctgctg cgccctgccc agcgactttg tccccctcgt 25920 gtaccgcgag tgccccccgc cgctgtgggg ccactgctac ctgttccaac tggccaacta 25980 cctgtcctac cacgcggacc tcatggagga ctccagcggc gaggggctca tggagtgcca 26040 ctgccgctgc aacctctgca cgccccaccg ctccctggtc tgcaacaccc aactgctcag 26100 cgagagtcag attatcggta ccttcgagct acagggtccg tcctcctcag acgagaagtc 26160 cgcggctccg gggctaaaac tcactccggg gctgtggact tccgcctacc tgcgcaaatt 26220 tgtacctgaa gactaccacg cccacgaaat caggttttac gaggaccaat cccgcccgcc 26280 caaggcggag ctgaccgcct gcgtcatcac ccagggcgag atcctaggcc aattgcaagc 26340 catccaaaaa gcccgccaag agtttttgct gaagaggggt cggggggtgt atctggaccc 26400 ccagtcgggt gaggagctca acccggttcc cccgctgcca ccgccgcggg accttgcttc 26460 ccaggataag catcgccatg gctcccagaa agaagcagca gcggccgccg ctgccgccgc 26520 cccacatgct ggaggaagag gaggaatact gggacagtca ggcagaggag gtttcggacg 26580 aggaggagcc ggagacggag atggaagagt gggaggagga cagcttagac gaggaggctt 26640 ccgaagccga agaggcaggc gcaacaccgt caccctcggc cgcagccccc tcgcaggcgc 26700 ccccgaagtc cgctcccagc atcagcagca acagcagcgc tataacctcc gctcctccac 26760 cgccgcgacc cacggccgac cgcagaccca accgtagatg ggacaccacc ggaaccgggg 26820 ccggtaagtc ctccgggaga ggcaagcaag cgcagcgcca aggctaccgc tcgtggcgcg 26880 ctcacaagaa cgccatagtc gcttgcttgc aagactgcgg ggggaacatc tccttcgccc 26940 gccgcttcct gctcttccac cacggtgtgg ccttcccccg taacgtcctg cattactacc 27000 gtcatctcta cagcccctac tgcggcggca gtgagccaga ggcggccagc ggcggcggcg 27060 cccgtttcgg tgcctaggaa gacccagggc aagacttcag ccaagaaact cgcggcgacc 27120 gcggcgaacg cggtcgcggg ggccctgcgc ctgacggtga acgaacccct gtcgacccgc 27180 gaactgagga accgaatctt ccccactctc tatgccatct tccagcagag cagagggcag 27240 gatcaggaac tgaaagtaaa aaacaggtct ctgcgctccc tcacccgcag ctgtctgtat 27300 cacaagagcg aagaccagct tcggcgcacg ctggaggacg ctgaggcact cttcagcaaa 27360 tactgcgcgc tcactcttaa ggactagctc cgcgcccttc tcgaatttag gcgggaacgc 27420 ctacgtcatc gcagcgccgc cgtcatgagc aaggacattc ccacgccata catgtggagc 27480 tatcagccgc agatgggact cgcggcgggc gcctcccaag actactccac ccgcatgaac 27540 tggctcagtg ccggcccaca catgatctca caggttaatg acatccgcac ccatcgaaac 27600 caaatattgg tgaagcaggc ggcaattacc accacgcccc gcaataatcc caaccccagg 27660 gagtggcccg cgtccctggt gtatcaggaa attcccggcc ccaccaccgt actacttccg 27720 cgtgattccc aggccgaagt ccaaatgact aactcagggg cacagctcgc gggcggctgt 27780 cgtcacaggg tgcggcctcc tcgccagggt ataactcacc tggagatccg aggcagaggt 27840 attcagctca acgacgagtc ggtgagctcc tcgctcggtc tcagacctga cgggaccttc 27900 cagatagccg gagccggccg atcttccttc acgccccgcc aggcgtacct gactctgcag 27960 agctcgtcct cggcgccgcg ctcgggcggc atcgggactc tccagttcgt gcaggagttt 28020 gtgccctcgg tctacttcaa ccccttctcg ggctctcccg gtcgctaccc ggaccagttt 28080 atcccgaact ttgacgccgc gagggactcg gtggacggct acgactgaat gtcgggtgga 28140 cccggtgcag agcaacttcg cctgaagcac cttgaccact gccgccgccc tcagtgcttt 28200 gcccgctgtc agaccggtga gttccagtac ttttccctgc ccgactcgca cccggacggc 28260 ccggcgcacg gggtgcgctt tttcatcccg agtcaggtcc gctctaccct aatcagggag 28320 ttcaccgccc gtcccctact ggcggagttg gaaaaggggc cttctatcct aaccattgcc 28380 tgcatttgct ctaaccctgg attacaccaa gatctttgct gtcatttgtg tgctgagtat 28440 aataaaggct gagatcagaa tctactcggg ctcctgtcgc catcctgtca acgccaccgt 28500 ccaagcccgg cccgatcagc ccgaggtgaa cctcacctgt ggtctgcacc ggcgcctgag 28560 gaaataccta gcttggtact acaacagcac tccctttgtg gtttacaaca gctttgacca 28620 ggacggggtc tcactgaggg ataacctctc gaacctgagc tactccatca ggaagaacaa 28680 caccctcgag ctacttcctc cttacctgcc cgggacttac cagtgtgtca ccggcccctg 28740 cacccacacc cacctgttga tcgtaaacga ctctcttccg agaacagacc tcaataactc 28800 ctctccgcag ttccccagaa caggaggtga gctcaggaaa ccccgggtaa agaagggtgg 28860 acaagagtta acacttgtgg ggtttctggt atatgtgacg ctggtggtgg ctcttttgat 28920 taaggctttt ccttccatgt ctgaactatc cctcttcttt tatgaacaac tcgactagtg 28980 ctaacgggac cctacccaac gaatcgggat tgaatatcgg taaccaggtt gcagtttcac 29040 ttttgattac cttcatagtc ctcttcctgc tagtgctgtc gcttctgtgc ctgcggatcg 29100 ggggctgctg catccacgtt tatatctggt gctggctgtt tagaaggttc ggagaccacc 29160 gcaggtagaa taatgctgct taccctcttt gtcctggcgc tggctgccag ctgccaagcc 29220 ttttccgagg ctgacttcat agagccccag tgcaatatca cttataaatc tgaacgtgcc 29280 atctgtacta ttctaatcaa atgtgttact caacacgata aggtgactgt taaatacaaa 29340 gatcaattaa aaaaagacgc actttacagc agctggcaac caggagatga tcaaaaatac 29400 aatgtaaccg tcttccaggg caaactctcc aaaacttaca attacaattt cccatttgag 29460 cagatgtgtg actttgtcat gtacatggaa aagcagtaca agctgtggcc tccaactccc 29520 cagggctgtg tggaaaatcc aggctctttc tgtatgatct ctctctgtgt aactgtgctg 29580 gcactaatac tcacgcttct gtatctcaga tttaaatcaa ggcaaagctt cattgatgaa 29640 aagaaaatgc cataatcgct caacgcttga ttgctaacac cgggttttta tccgcagaat 29700 gattggaatc accctactaa tcacctccct ccttgcgatt gcccatgggt tggaacgaat 29760 cgaagtccct gtgggggcca atgttaccct ggtggggcct gtcggcaatg ctacattaat 29820 gtgggaaaaa tatactaaaa atcaatgggt ttcttactgc actaacaaaa acagccacaa 29880 gcccagagcc atctgcgatg ggcaaaatct aaccttgatt gatgttcaat tgctggatgc 29940 gggctactat tatgggcagc tgggtacaat gattaattac tggagacccc acagagatta 30000 catgcttcac gtagtaaagg gtcccattag cagcccaacc accacctcta ccacacccac 30060 taccaccact actcccacca ccagcactgc cgcccagcct cctcatagca gaacaaccac 30120 ttttatcaat tccaagtccc actcccccca cattgccggc gggccctccg cctcagactc 30180 cgagaccacc gagatctgct tctgcaaatg ctctgacgcc attgcccagg atttggaaga 30240 tcacgaggaa gatgagcatg actacgcaga tgcatgccag gcatcagagg cagaagcgct 30300 accggtggcc ctaaaacagt atgcagactc ccacaccacc cccaaccttc ctccaccttc 30360 ccagaagcca agtttcctgg gggaaaatga aactctgcct ctttccatac tagctctgac 30420 atctgttgct attttggccg ctctgctggt gcttctatgc tctatatgct acctgatctg 30480 ctgcagaaag aaaaaatctc acggccatgc tcaccagccc ctcatgcact tcccttaccc 30540 tccagagctg ggcgaccaca aactttaagt ctgcagtagc tatctgccca tcccttgtca 30600 gtcgacagcg atgagcccca ctaatctaac agcctctgga cttacaacat tgtctcttaa 30660 tgagaccacc gctcctcaag acctgtacga tggtgtctcc gcgctggtta accagtggga 30720 tcacctgggc atatggtggc tcctcatagg agcagtgacc ctgtgcctaa tcctggtctg 30780 gatcatctgc tgcatcaaaa gcagaagacc caggcggcgg cccatctaca ggcccttcgt 30840 catcacacct gaagataatg atgatgatga caccacctcc aggctgcaga gcctaaagca 30900 gctactcttc tcttttacag catggtaaat tgaatcatgc cccgcatttt catctacttg 30960 cttctccttc cactttttct gggctcctct acattggcca ctgtgtccca catcgaggta 31020 gactgcctca cgcccttcac agtctacctg cttttcggct ttgtcatctg cacctttgtc 31080 tgcagcgtta tcactgtagt gatctgcttc atacagtgca tcgactacat ctgtgtgcgg 31140 gtggcctact ttagacacca cccccagtat cgcaacaggg acatagcggc tctcctaaga 31200 cttgtttaaa tcatggccaa attacctgtg attggtcttc tgattatctg ctgcgtccta 31260 gccgcgattg ggactcaacc taataccacc accagcgctc ccagaaagag acatgtatcc 31320 tgcagcttca agcgtccctg gaatataccc caatgcttta ctgatgaacc tgaaatctct 31380 ttggcttggt acttcagcgt caccgccctt ctcatcttct gcagtacggt tattgctctt 31440 gccatctacc cttcccttaa cctgggctgg aatgctgtca actctatgga atatcccacc 31500 ttcccagaac cagacctgcc agacctggtt gttctaaacg cgtttcctcc tcctccagtt 31560 caaaatcagt ttcgccctcc gtcccctacg cccactgagg tcagctactt taatctaaca 31620 ggcggagatg actgaaaacc tagacctaga aatggacggt ctctgcagcg agcaacgcac 31680 actagagagg cgccggcaaa aagcagagct cgagcgtctt aaacaagagc tccaagacgc 31740 cgtggccata caccagtgca aaaaagggct cttctgtctg gtaaaacagg ccacgctcac 31800 ctatgaaaaa acaggtgaca cccaccgcct aggatacaag ctgcccacac agcgccaaaa 31860 gtttgccctt atgataggtg aacaacccat caccgtcacc cagcactccg tggagacaga 31920 aggctgcatt catgctccct gcaggggcgc tgactgcctc tacaccttga tcaaaaccct 31980 ctgcggtctc agagacctta tccctttcaa ttgatcataa ctgtaatcaa taaaaaatca 32040 cttacttgaa atctgatagc aagactctgt ccaatttttt cagcaacact tccttcccct 32100 cctcccaact ctggtactct aggcgcctcc tagctgcaaa cttcctccac agtctgaagg 32160 gaatgtcaga ttcctcctcc tgtccctccg cacccacgat cttcatgttg ttacagatga 32220 aacgcgcgag atcgtctgac gagaccttca accccgtgta cccctacgat accgagatcg 32280 ctccgacttc tgtccctttc cttacccctc cctttgtatc atccgcagga atgcaagaaa 32340 atccagctgg ggtgctgtcc ctgcacctgt cagagcccct taccacccac aatggggccc 32400 tgactctaaa aatggggggc ggcctgaccc tggacaagga agggaatctc acttcccaaa 32460 acatcaccag tgtcgatccc cctctcaaaa aaagcaagaa caacatcagc cttcagaccg 32520 ccgcacccct cgccgtcagc tccggggccc taaccctttt tgccactccc cccctagcgg 32580 tcagtggcga caaccttact gtgcagtctc aggcccctct tactttggaa gactcaaaac 32640 taactctggc caccaaagga cccctaactg tgtccgaagg caaacttgtc ctagaaacag 32700 agcctcccct gcatgcaagt gacagcagta gcctgggcct tagcgtcacg gccccactta 32760 gcattaacaa tgacagccta ggactagaca tgcaagcgcc catcagctct cgagatggaa 32820 aactggctct aacagtggcg gcccccctaa ctgtggccga gggtatcaat gctttggcag 32880 tagccacagg taatggtatt ggactaaatg aaaccaacac acacctgcag gcaaaactgg 32940 tcgcgcccct aggctttgat accaacggca acattaagct aagcgtcgca ggaggcatga 33000 ggctaaacaa taacacactg atactagatg taaactaccc atttgaggct caaggccaac 33060 tgagcctaag agtgggctcg ggcccactat atgtagattc tagtagtcat aacctaacca 33120 ttagatgcct taggggattg tatgtaacat cttctaacaa ccaaaacggt ctagaggcca 33180 acattaaact aacaaaaggc cttgtgtatg acggaaatgc catagcagtt aatgttggca 33240 aagggctgga atacagccct actggcacaa cagaaaaacc tatacagact aaaataggtc 33300 taggcatgga gtatgacact gagggagcca tgatgacaaa actaggctct ggactaagct 33360 ttgacaattc aggagccatt gtggtgggaa acaaaaatga tgacaggctt actttgtgga 33420 ccacaccgga cccatcgccc aactgtcaga tttactctga aaaagatgct aaactaacct 33480 tggtactgac taaatgtggc agtcaggttg taggcacagt atctattgcc gctcttaaag 33540 gtagccttgt gccaatcact agtgcaatca gtgtggttca gatataccta aggtttgatg 33600 aaaatggggt gctgatgagt aactcttcac ttaatggcga atactggaat tttagaaacg 33660 gagactcaac taatggcaca ccatatacaa acgcagtggg ttttatgcct aatctactgg 33720 cctatcctaa aggtcaaact acaactgcaa aaagtaacat tgtcagccag gtctacatga 33780 acggggacga tactaaaccc atgacattta caatcaactt caatggcctt agtgaaacag 33840 gggatacccc tgtcagtaaa tattccatga cattctcatg gaggtggcca aatggaagct 33900 acatagggca caattttgta acaaactcct ttactttctc ctacatcgcc caagaataaa 33960 gaaagcacag agatgcttgt ttttgatttc aaaattgtgt gcttttattt attttcaagc 34020 ttacagtatt tccagtagtc attagaatag agcttaatta aactgcatga gaacccttcc 34080 acatagctta aattatcacc agtgcaaatg gaaaaaaatc aacatacctt tttatccaga 34140 tatcaaagaa ctctagtggt cagttttccc ccaccctccc agctcacaga atacacagtc 34200 ctttcccccc ggctggcttt aaacaacact atctcattgg taacagacat atttttaggt 34260 gtaataatcc acacggtctc ttggcgggcc aaacgctggt ctgtgatgtt aataaactcc 34320 ccaggcagct ctttcaagtt cacgtcgctg tccaactgct gaagcgctcg cggctccgac 34380 tgcgcctcta gcggaggcaa cggcagcacc cgatccttga tctataaagg agtagagtca 34440 taatccccca taagaatagg gcggtgatgc agcaacaagg cgcgcagcaa ctcctgccgc 34500 cgcctctccg tacgacagga atgcaacggg gtggtggtct cctccgcgat aatccgcacc 34560 gctcgcagca tcagcatcct cgtcctccgg gcacagcagc gcatcctgat ctcactgaga 34620 tcggcgcagt aagtgcagca caacaccaag atgttattta agatcccaca gtgcaaagca 34680 ctgtacccaa agctcatggc gggaaggaca gcccccacgt gaccatcgta ccagatcctc 34740 aggtaaatca aatgacgacc tctcataaac acgctggaca tatacatcac ctccttgggc 34800 atgagctgat tcaccacctc tcgataccac aggcatcgct gattaattaa agacccctcg 34860 agcaccatcc tgaaccagga agccagcacc tgaccccccg ccaggcactg cagggacccc 34920 ggtgaatcgc agtggcagtg aagactccag cgctcgtagc cgtgaaccat agagctggtc 34980 attatatcca cattggcaca acacagacac actttcatac actttttcat gattagcagc 35040 tcctctctag tcaagaccat atcccaagga atcacccact cttgaatcaa ggtaaatccc 35100 acacagcagg gcaggcctct cacataactc acgttatgca tagtgagcgt gtcgcaatct 35160 ggaaataccg gatgatcttc catcaccgaa gcccgggtct ccgtctcaaa gggaggtaaa 35220 cggtccctcg tgtagggaca gtggcgggat aatcgagatc gtgttgaacg tagagtcatg 35280 ccaaagggaa cagcggacgt actcatattt cctccagcag aaccaagtgc gcgcgtggca 35340 gctatccctg cgtcttctgt ctcgccgcct gccccgctcg gtgtagtagt tgtaatacag 35400 ccactccctc agaccgtcaa ggcgctccct ggcgtccgga tctataacaa caccgtcctg 35460 cagcgccgcc ctgatgacat ccaccaccgt agagtatgcc aagcccagcc acgaaatgca 35520 ctcactttga cagcgagaga taggaggagc gggaagagat ggaagaacca tgatagtaaa 35580 agaactttta ttccaatcga tcctctacaa tgtcaaagtg tagatctatc agatggcact 35640 ggtctcctcc gctgagtcga tcaaaaataa cagctaaacc acaaacaaca cgattggtca 35700 aatgctgcac aagggcttgc agcataaaat cgcctcgaaa gtccaccgca agcataacat 35760 caaagccacc gcccctatca tgatctatga taaaaacccc acagctatcc accagaccca 35820 tatagttttc atctctccat cgtgaaaaaa tatttacaag ctcctccttt aaatcacctc 35880 caaccaattc aaaaagttga gccagaccgc cctccacctt cattttcagc atgcgcatca 35940 tgattgcaaa aattcaggct cctcagacac ctgtataaga ttgagaagcg gaacgttaac 36000 atcaatgttt cgctcgcgaa gatcgcgcct cagtgcaagc atgatataat cccacaggtc 36060 ggagcggatc agcgaggaca tctccccgcc aggaaccaac tcaacggagc ctatgctgat 36120 tataatacgc atattcgggg ctatgctaac cagcacggcc cccaaatagg cgtactgcat 36180 aggcggcgac aaaaagtgaa cagtttgggt taaaaaatca ggcaaacact cgcgcaaaaa 36240 agcaagaaca tcataaccat gctcatgcaa atagatgcaa gtaagctcag gaacgaccac 36300 agaaaaatgc acaatttttc tctcaaacat gactgcgagc cctgcaaaaa ataaaaaaga 36360 aacattacac aagagtagcc tgtcttacaa tgggatagac tactctaacc aacataagac 36420 gggccacgac atcgcccgcg tggccataaa aaaaattatc cgtgtgatta aaaagaagca 36480 cagatagctg gccagtcata tccggagtca tcacgtgcga acccgtgtag acccccgggt 36540 tggacacatc ggccaaacaa agaaagcggc caatgtatcc cggaggaatg ataacactaa 36600 gacgaagata caacagaata accccatggg ggggaataac aaagttagta ggtgaataaa 36660 aacgataaac acccgaaact ccctcctgcg taggcaaaat agcgccctcc ccttccaaaa 36720 caacatacag cgcttccaca gcagccatga caaaagactc aaaacactca aaagactcag 36780 tcttaccagg aaaataaaag cactctcaca gcaccagcac taatcagagt gtgaagaggg 36840 ccaagtgccg aacgagtata tataggaatt aaaaatgacg taaatgtgta aaggtcaaaa 36900 aacgcccaga aaaatacaca gaccaacgcc cgaaacgaaa acccgcgaaa aaatacccag 36960 aagttcctca acaaccgcca cttccgcttt cccacgatac gtcacttcct caaaaatagc 37020 aaactacatt tcccacatgt acaaaaccaa aacccctccc cttgtcaccg cccacaactt 37080 acataatcac aaacgtcaaa gcctacgtca cccgccccgc ctcgccccgc ccacctcatt 37140 atcatattgg cctcaatcca aaataaggta tattattgat gatg 37184 <210> 11 <211> 29 <212> PRT <213> Great Ape Adenovirus <400> 11 Glu Gln Glu Glu Asn Gln Val Val Ala Ala Asp Asp Glu Leu Glu Asp 1 5 10 15 Glu Glu Ala Gln Ala Gln Glu Glu Ala Pro Val Lys Lys 20 25 <210> 12 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 12 Ile Gln Ile Gly Thr Glu Val Val Gly Asp Thr Ser Lys Asp Thr 1 5 10 15 <210> 13 <211> 7 <212> PRT <213> Great Ape Adenovirus <400> 13 Asn Glu Ala Asp Ala Thr Ala 1 5 <210> 14 <211> 12 <212> PRT <213> Great Ape Adenovirus <400> 14 Met Val Ala Asn Glu Gln Gly Val Leu Glu Ser Lys 1 5 10 <210> 15 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 15 Asn Thr Thr Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 1 5 10 15 <210> 16 <211> 9 <212> PRT <213> Great Ape Adenovirus <400> 16 Lys Lys Asp Asp Val Asn Ala Lys Ile 1 5 <210> 17 <211> 26 <212> PRT <213> Great Ape Adenovirus <400> 17 Val Thr Asp Thr Tyr Gln Gly Ile Lys Asn Thr Asn Gly Asn Gly Gln 1 5 10 15 Trp Thr Lys Asp Asp Gln Phe Ala Asp Arg 20 25 <210> 18 <211> 29 <212> PRT <213> Great Ape Adenovirus <400> 18 Glu Gln Glu Glu Asn Gln Val Glu Ala Ala Asp Glu Asp Val Glu Asp 1 5 10 15 Glu Glu Ala Gln Ala Gln Glu Glu Ala Pro Ala Lys Lys 20 25 <210> 19 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 19 Leu Gln Ile Gly Thr Glu Val Val Gly Glu Thr Ser Lys Asp Thr 1 5 10 15 <210> 20 <211> 7 <212> PRT <213> Great Ape Adenovirus <400> 20 Asn Glu Ala Asp Ala Ala Val 1 5 <210> 21 <211> 12 <212> PRT <213> Great Ape Adenovirus <400> 21 Leu Val Ala Asn Glu Gln Gly Val Met Glu Ser Lys 1 5 10 <210> 22 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 22 Asn Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 1 5 10 15 <210> 23 <211> 9 <212> PRT <213> Great Ape Adenovirus <400> 23 Lys Lys Asp Asp Val Asn Ala Lys Val 1 5 <210> 24 <211> 26 <212> PRT <213> Great Ape Adenovirus <400> 24 Ile Thr Asp Thr Tyr Gln Gly Val Lys Asn Thr Asn Gly Asn Gly Gln 1 5 10 15 Trp Thr Lys Asp Asp Gln Phe Ala Asp Arg 20 25 <210> 25 <211> 30 <212> PRT <213> Great Ape Adenovirus <400> 25 Glu Gln Glu Glu Asn Gln Val Val Ala Ala Asp Glu Asp Leu Glu Glu 1 5 10 15 Asp Glu Glu Ala Gln Ala Glu Glu Gln Ala Pro Ala Lys Lys 20 25 30 <210> 26 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 26 Leu Gln Ile Gly Thr Glu Val Val Gly Asp Thr Ser Lys Asp Thr 1 5 10 15 <210> 27 <211> 7 <212> PRT <213> Great Ape Adenovirus <400> 27 Asn Glu Ala Asp Ala Thr Ala 1 5 <210> 28 <211> 12 <212> PRT <213> Great Ape Adenovirus <400> 28 Met Val Ala Asn Glu Gln Gly Val Leu Gln Ser Lys 1 5 10 <210> 29 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 29 Asn Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 1 5 10 15 <210> 30 <211> 9 <212> PRT <213> Great Ape Adenovirus <400> 30 Lys Lys Asp Asp Val Asn Ala Lys Val 1 5 <210> 31 <211> 26 <212> PRT <213> Great Ape Adenovirus <400> 31 Ile Thr Asp Thr Tyr Gln Gly Val Lys Asn Ser Asn Gly Asn Gly Gln 1 5 10 15 Trp Thr Lys Asp Asp Gln Phe Ala Asp Arg 20 25 <210> 32 <211> 31 <212> PRT <213> Great Ape Adenovirus <400> 32 Glu Gln Glu Glu Thr Gln Ala Ala Glu Glu Ala Val Asp Glu Glu Asp 1 5 10 15 Ala Glu Asp Glu Ala Gln Pro Gln Glu Glu Ala Pro Ala Lys Lys 20 25 30 <210> 33 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 33 Leu Gln Ile Gly Thr Glu Val Val Gly Asp Thr Ser Lys Asp Thr 1 5 10 15 <210> 34 <211> 7 <212> PRT <213> Great Ape Adenovirus <400> 34 Asn Glu Ala Asp Ala Ala Val 1 5 <210> 35 <211> 12 <212> PRT <213> Great Ape Adenovirus <400> 35 Met Val Ala Asn Glu Lys Gly Val Leu Gln Ser Lys 1 5 10 <210> 36 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 36 Asn Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 1 5 10 15 <210> 37 <211> 9 <212> PRT <213> Great Ape Adenovirus <400> 37 Thr Lys Asp Asp Val Asn Ala Lys Val 1 5 <210> 38 <211> 26 <212> PRT <213> Great Ape Adenovirus <400> 38 Ile Thr Asp Thr Tyr Gln Gly Val Lys Asn Thr Asn Gly Asn Gly Gln 1 5 10 15 Trp Thr Lys Asp Asp Gln Phe Ala Asp Arg 20 25 <210> 39 <211> 29 <212> PRT <213> Great Ape Adenovirus <400> 39 Glu Gln Glu Glu Asn Gln Val Val Ala Ala Asp Asp Glu Leu Glu Asp 1 5 10 15 Glu Glu Ala Gln Ala Gln Glu Glu Ala Pro Val Lys Lys 20 25 <210> 40 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 40 Leu Gln Ile Gly Thr Glu Val Val Gly Asp Thr Ser Lys Asp Thr 1 5 10 15 <210> 41 <211> 7 <212> PRT <213> Great Ape Adenovirus <400> 41 Asn Glu Ala Asp Ala Thr Val 1 5 <210> 42 <211> 12 <212> PRT <213> Great Ape Adenovirus <400> 42 Met Val Ala Asn Glu Gln Gly Val Leu Glu Ser Lys 1 5 10 <210> 43 <211> 15 <212> PRT <213> Great Ape Adenovirus <400> 43 Asn Thr Thr Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 1 5 10 15 <210> 44 <211> 9 <212> PRT <213> Great Ape Adenovirus <400> 44 Lys Lys Asp Asp Val Asn Ala Lys Ile 1 5 <210> 45 <211> 26 <212> PRT <213> Great Ape Adenovirus <400> 45 Val Thr Asp Thr Tyr Gln Gly Ile Lys Asn Thr Asn Gly Asn Gly Gln 1 5 10 15 Trp Thr Lys Asp Asp Gln Phe Ala Asp Arg 20 25 <210> 46 <211> 955 <212> PRT <213> Great Ape Adenovirus <400> 46 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Met Ser Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Asn Gln Val Val Ala 130 135 140 Ala Asp Asp Glu Leu Glu Asp Glu Glu Ala Gln Ala Gln Glu Glu Ala 145 150 155 160 Pro Val Lys Lys Ile His Val Tyr Ala Gln Ala Pro Leu Ser Gly Glu 165 170 175 Lys Ile Ser Lys Asp Gly Ile Gln Ile Gly Thr Glu Val Val Gly Asp 180 185 190 Thr Ser Lys Asp Thr Phe Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln 195 200 205 Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp Ala Thr Ala Ala Gly Gly 210 215 220 Arg Val Leu Lys Lys Thr Thr Pro Met Arg Pro Cys Tyr Gly Ser Tyr 225 230 235 240 Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln Gly Ile Met Val Ala Asn 245 250 255 Glu Gln Gly Val Leu Glu Ser Lys Val Glu Met Gln Phe Phe Ser Asn 260 265 270 Thr Thr Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu Pro Lys 275 280 285 Val Val Leu Tyr Ser Glu Asp Val His Leu Glu Ser Pro Asp Thr His 290 295 300 Leu Ser Tyr Lys Pro Lys Lys Asp Asp Val Asn Ala Lys Ile Met Leu 305 310 315 320 Gly Gln Gln Ala Met Pro Asn Arg Pro Asn Leu Ile Gly Phe Arg Asp 325 330 335 Asn Phe Ile Gly Leu Met Phe Tyr Asn Ser Thr Gly Asn Met Gly Val 340 345 350 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 355 360 365 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp 370 375 380 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 385 390 395 400 Pro Asp Val Arg Ile Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro 405 410 415 Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Val Thr Asp Thr Tyr Gln 420 425 430 Gly Ile Lys Asn Thr Asn Gly Asn Gly Gln Trp Thr Lys Asp Asp Gln 435 440 445 Phe Ala Asp Arg Asn Glu Ile Gly Val Gly Asn Asn Phe Ala Met Glu 450 455 460 Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val 465 470 475 480 Gly Leu Tyr Leu Pro Asp Lys Leu Lys Tyr Asn Pro Thr Asn Val Asp 485 490 495 Ile Ser Asp Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val 500 505 510 Ala Pro Gly Leu Val Asp Cys Phe Val Asn Val Gly Ala Arg Trp Ser 515 520 525 Leu Asp Tyr Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala 530 535 540 Gly Leu Arg Tyr Arg Ser Met Ile Leu Gly Asn Gly Arg Tyr Val Pro 545 550 555 560 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu 565 570 575 Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val 580 585 590 Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly 595 600 605 Ala Ser Ile Lys Phe Asp Ser Ile Thr Leu Tyr Ala Thr Phe Phe Pro 610 615 620 Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp 625 630 635 640 Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Gly Ala Asn Met Leu 645 650 655 Tyr Pro Ile Pro Ala Lys Ala Thr Asn Val Pro Ile Ser Ile Pro Ser 660 665 670 Arg Asn Trp Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr 675 680 685 Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr 690 695 700 Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr 705 710 715 720 Phe Lys Lys Ile Ser Ile Met Tyr Asp Ser Ser Val Ser Trp Pro Gly 725 730 735 Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Ala Val 740 745 750 Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 755 760 765 Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe 770 775 780 Tyr Ile Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 785 790 795 800 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Thr Asn Tyr Lys Asp 805 810 815 Tyr Gln Ala Ile Gly Ile Thr His Gln His Asn Asn Ser Gly Phe Val 820 825 830 Gly Tyr Leu Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn 835 840 845 Phe Pro Tyr Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Val Thr Gln 850 855 860 Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser 865 870 875 880 Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu 885 890 895 Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro 900 905 910 Met Asp Glu Pro Thr Leu Leu Tyr Ile Val Phe Glu Val Phe Asp Val 915 920 925 Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu 930 935 940 Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 47 <211> 955 <212> PRT <213> Great Ape Adenovirus <400> 47 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Met Ser Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Asn Gln Val Glu Ala 130 135 140 Ala Asp Glu Asp Val Glu Asp Glu Glu Ala Gln Ala Gln Glu Glu Ala 145 150 155 160 Pro Val Lys Lys Ile His Val Tyr Ala Gln Ala Pro Leu Ala Gly Glu 165 170 175 Lys Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Glu Val Val Gly Glu 180 185 190 Thr Ser Lys Asp Thr Phe Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln 195 200 205 Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp Ala Ala Val Ala Gly Gly 210 215 220 Arg Val Leu Lys Lys Thr Thr Pro Met Arg Pro Cys Tyr Gly Ser Tyr 225 230 235 240 Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln Gly Ile Leu Val Ala Asn 245 250 255 Glu Gln Gly Val Met Glu Ser Lys Val Glu Met Gln Phe Phe Ser Asn 260 265 270 Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu Pro Lys 275 280 285 Val Val Leu Tyr Ser Glu Asp Val His Leu Glu Ser Pro Asp Thr His 290 295 300 Leu Ser Tyr Lys Pro Lys Lys Asp Asp Val Asn Ala Lys Val Met Leu 305 310 315 320 Gly Gln Gln Ala Met Pro Asn Arg Pro Asn Leu Ile Gly Phe Arg Asp 325 330 335 Asn Phe Ile Gly Leu Met Phe Tyr Asn Ser Thr Gly Asn Met Gly Val 340 345 350 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 355 360 365 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser Ile Gly Asp 370 375 380 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 385 390 395 400 Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 405 410 415 Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Ile Thr Asp Thr Tyr Gln 420 425 430 Gly Val Lys Asn Thr Asn Gly Asn Gly Gln Trp Thr Lys Asp Asp Gln 435 440 445 Phe Ala Asp Arg Asn Glu Ile Gly Val Gly Asn Asn Phe Ala Met Glu 450 455 460 Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val 465 470 475 480 Gly Leu Tyr Leu Pro Asp Lys Leu Lys Tyr Asn Pro Thr Asn Val Asp 485 490 495 Ile Ser Asp Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val 500 505 510 Ala Pro Gly Leu Val Asp Cys Phe Val Asn Val Gly Ala Arg Trp Ser 515 520 525 Leu Asp Tyr Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala 530 535 540 Gly Leu Arg Tyr Arg Ser Met Ile Leu Gly Asn Gly Arg Tyr Val Pro 545 550 555 560 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu 565 570 575 Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val 580 585 590 Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly 595 600 605 Ala Ser Ile Lys Phe Asp Ser Ile Thr Leu Tyr Ala Thr Phe Phe Pro 610 615 620 Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp 625 630 635 640 Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Gly Ala Asn Met Leu 645 650 655 Tyr Pro Ile Pro Ala Lys Ala Thr Asn Val Pro Ile Ser Ile Pro Ser 660 665 670 Arg Asn Trp Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr 675 680 685 Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr 690 695 700 Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr 705 710 715 720 Phe Lys Lys Ile Ser Ile Met Tyr Asp Ser Ser Val Ser Trp Pro Gly 725 730 735 Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Ala Val 740 745 750 Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 755 760 765 Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe 770 775 780 Tyr Ile Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 785 790 795 800 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Thr Asn Tyr Lys Asp 805 810 815 Tyr Gln Ala Ile Gly Ile Thr His Gln His Asn Asn Ser Gly Phe Val 820 825 830 Gly Tyr Leu Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn 835 840 845 Phe Pro Tyr Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Val Thr Gln 850 855 860 Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser 865 870 875 880 Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu 885 890 895 Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro 900 905 910 Met Asp Glu Pro Thr Leu Leu Tyr Ile Val Phe Glu Val Phe Asp Val 915 920 925 Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu 930 935 940 Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 48 <211> 956 <212> PRT <213> Great Ape Adenovirus <400> 48 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Met Ser Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Asn Gln Val Val Ala 130 135 140 Ala Asp Glu Asp Leu Glu Glu Asp Glu Glu Ala Gln Ala Glu Glu Gln 145 150 155 160 Ala Pro Val Lys Lys Ile His Val Tyr Ala Gln Ala Pro Leu Ala Gly 165 170 175 Glu Lys Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Glu Val Val Gly 180 185 190 Asp Thr Ser Lys Asp Thr Phe Ala Asp Lys Thr Phe Gln Pro Glu Pro 195 200 205 Gln Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp Ala Thr Ala Ala Gly 210 215 220 Gly Arg Val Leu Lys Lys Thr Thr Pro Met Arg Pro Cys Tyr Gly Ser 225 230 235 240 Tyr Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln Gly Ile Met Val Ala 245 250 255 Asn Glu Gln Gly Val Leu Gln Ser Lys Val Glu Met Gln Phe Phe Ser 260 265 270 Asn Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu Pro 275 280 285 Lys Val Val Leu Tyr Ser Glu Asp Val His Leu Glu Ser Pro Asp Thr 290 295 300 His Leu Ser Tyr Lys Pro Lys Lys Asp Asp Val Asn Ala Lys Val Met 305 310 315 320 Leu Gly Gln Gln Ala Met Pro Asn Arg Pro Asn Leu Ile Gly Phe Arg 325 330 335 Asp Asn Phe Ile Gly Leu Met Phe Tyr Asn Ser Thr Gly Asn Met Gly 340 345 350 Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln 355 360 365 Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser Ile Gly 370 375 380 Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr 385 390 395 400 Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu 405 410 415 Pro Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Ile Thr Asp Thr Tyr 420 425 430 Gln Gly Val Lys Asn Ser Asn Gly Asn Gly Gln Trp Thr Lys Asp Asp 435 440 445 Gln Phe Ala Asp Arg Asn Glu Ile Gly Val Gly Asn Asn Phe Ala Met 450 455 460 Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn 465 470 475 480 Val Gly Leu Tyr Leu Pro Asp Lys Leu Lys Tyr Asn Pro Thr Asn Val 485 490 495 Asp Ile Ser Asp Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val 500 505 510 Val Ala Pro Gly Leu Val Asp Cys Phe Val Asn Val Gly Ala Arg Trp 515 520 525 Ser Leu Asp Tyr Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 530 535 540 Ala Gly Leu Arg Tyr Arg Ser Met Ile Leu Gly Asn Gly Arg Tyr Val 545 550 555 560 Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu 565 570 575 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp 580 585 590 Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp 595 600 605 Gly Ala Ser Ile Lys Phe Asp Ser Ile Thr Leu Tyr Ala Thr Phe Phe 610 615 620 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 625 630 635 640 Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Gly Ala Asn Met 645 650 655 Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Val Pro Ile Ser Ile Pro 660 665 670 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys 675 680 685 Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val 690 695 700 Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His 705 710 715 720 Thr Phe Lys Lys Ile Ser Ile Met Tyr Asp Ser Ser Val Ser Trp Pro 725 730 735 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Ala 740 745 750 Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp 755 760 765 Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly 770 775 780 Phe Tyr Ile Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg 785 790 795 800 Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Thr Asn Tyr Lys 805 810 815 Asp Tyr Gln Ala Ile Gly Ile Thr His Gln His Asn Asn Ser Gly Phe 820 825 830 Val Gly Tyr Leu Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala 835 840 845 Asn Phe Pro Tyr Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Val Thr 850 855 860 Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser 865 870 875 880 Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu 885 890 895 Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp 900 905 910 Pro Met Asp Glu Pro Thr Leu Leu Tyr Ile Val Phe Glu Val Phe Asp 915 920 925 Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr 930 935 940 Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 49 <211> 957 <212> PRT <213> Great Ape Adenovirus <400> 49 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Met Ser Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Thr Gln Ala Ala Glu 130 135 140 Glu Ala Val Asp Glu Glu Asp Ala Glu Asp Glu Ala Gln Pro Gln Glu 145 150 155 160 Glu Ala Pro Val Lys Lys Ile His Val Tyr Ala Gln Ala Pro Leu Ala 165 170 175 Gly Glu Lys Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Glu Val Val 180 185 190 Gly Asp Thr Ser Lys Asp Thr Phe Ala Asp Lys Thr Phe Gln Pro Glu 195 200 205 Pro Gln Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp Ala Ala Val Ala 210 215 220 Gly Gly Arg Val Leu Lys Lys Thr Thr Pro Met Arg Pro Cys Tyr Gly 225 230 235 240 Ser Tyr Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln Gly Ile Met Val 245 250 255 Ala Asn Glu Lys Gly Val Leu Gln Ser Lys Val Glu Met Gln Phe Phe 260 265 270 Ser Asn Thr Ser Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu 275 280 285 Pro Lys Val Val Leu Tyr Ser Glu Asp Val His Leu Glu Ser Pro Asp 290 295 300 Thr His Leu Ser Tyr Lys Pro Thr Lys Asp Asp Val Asn Ala Lys Val 305 310 315 320 Met Leu Gly Gln Gln Ala Met Pro Asn Arg Pro Asn Leu Ile Gly Phe 325 330 335 Arg Asp Asn Phe Ile Gly Leu Met Phe Tyr Asn Ser Thr Gly Asn Met 340 345 350 Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu 355 360 365 Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser Ile 370 375 380 Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser 385 390 395 400 Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu 405 410 415 Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Ile Thr Asp Thr 420 425 430 Tyr Gln Gly Val Lys Asn Thr Asn Gly Asn Gly Gln Trp Thr Lys Asp 435 440 445 Asp Gln Phe Ala Asp Arg Asn Glu Ile Gly Val Gly Asn Asn Phe Ala 450 455 460 Met Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala 465 470 475 480 Asn Val Gly Leu Tyr Leu Pro Asp Lys Leu Lys Tyr Asn Pro Thr Asn 485 490 495 Val Asp Ile Ser Asp Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg 500 505 510 Val Val Ala Pro Gly Leu Val Asp Cys Phe Val Asn Val Gly Ala Arg 515 520 525 Trp Ser Leu Asp Tyr Met Asp Asn Val Asn Pro Phe Asn His His Arg 530 535 540 Asn Ala Gly Leu Arg Tyr Arg Ser Met Ile Leu Gly Asn Gly Arg Tyr 545 550 555 560 Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn 565 570 575 Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys 580 585 590 Asp Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val 595 600 605 Asp Gly Ala Ser Ile Lys Phe Asp Ser Ile Thr Leu Tyr Ala Thr Phe 610 615 620 Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 625 630 635 640 Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Gly Ala Asn 645 650 655 Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Val Pro Ile Ser Ile 660 665 670 Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu 675 680 685 Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe 690 695 700 Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn 705 710 715 720 His Thr Phe Lys Lys Ile Ser Ile Met Tyr Asp Ser Ser Val Ser Trp 725 730 735 Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg 740 745 750 Ala Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys 755 760 765 Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln 770 775 780 Gly Phe Tyr Ile Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe 785 790 795 800 Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Thr Asn Tyr 805 810 815 Lys Asp Tyr Gln Ala Ile Gly Ile Thr His Gln His Asn Asn Ser Gly 820 825 830 Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro 835 840 845 Ala Asn Phe Pro Tyr Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Val 850 855 860 Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe 865 870 875 880 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn 885 890 895 Leu Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val 900 905 910 Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr Ile Val Phe Glu Val Phe 915 920 925 Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val 930 935 940 Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 50 <211> 955 <212> PRT <213> Great Ape Adenovirus <400> 50 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Met Ser Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Asn Gln Val Val Ala 130 135 140 Ala Asp Asp Glu Leu Glu Asp Glu Glu Ala Gln Ala Gln Glu Glu Ala 145 150 155 160 Pro Val Lys Lys Ile His Val Tyr Ala Gln Ala Pro Leu Ser Gly Glu 165 170 175 Lys Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Glu Val Val Gly Asp 180 185 190 Thr Ser Lys Asp Thr Phe Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln 195 200 205 Ile Gly Glu Ser Gln Trp Asn Glu Ala Asp Ala Thr Val Ala Gly Gly 210 215 220 Arg Val Leu Lys Lys Thr Thr Pro Met Arg Pro Cys Tyr Gly Ser Tyr 225 230 235 240 Ala Arg Pro Thr Asn Ala Asn Gly Gly Gln Gly Ile Met Val Ala Asn 245 250 255 Glu Gln Gly Val Leu Glu Ser Lys Val Glu Met Gln Phe Phe Ser Asn 260 265 270 Thr Thr Thr Leu Asn Ala Arg Asp Gly Thr Gly Asn Pro Glu Pro Lys 275 280 285 Val Val Leu Tyr Ser Glu Asp Val His Leu Glu Ser Pro Asp Thr His 290 295 300 Leu Ser Tyr Lys Pro Lys Lys Asp Asp Val Asn Ala Lys Ile Met Leu 305 310 315 320 Gly Gln Gln Ala Met Pro Asn Arg Pro Asn Leu Ile Gly Phe Arg Asp 325 330 335 Asn Phe Ile Gly Leu Met Phe Tyr Asn Ser Thr Gly Asn Met Gly Val 340 345 350 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 355 360 365 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser Ile Gly Asp 370 375 380 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 385 390 395 400 Pro Asp Val Arg Ile Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro 405 410 415 Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly Val Thr Asp Thr Tyr Gln 420 425 430 Gly Ile Lys Asn Thr Asn Gly Asn Gly Gln Trp Thr Lys Asp Asp Gln 435 440 445 Phe Ala Asp Arg Asn Glu Ile Gly Val Gly Asn Asn Phe Ala Met Glu 450 455 460 Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val 465 470 475 480 Gly Leu Tyr Leu Pro Asp Lys Leu Lys Tyr Asn Pro Thr Asn Val Asp 485 490 495 Ile Ser Asp Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val 500 505 510 Ala Pro Gly Leu Val Asp Cys Phe Val Asn Val Gly Ala Arg Trp Ser 515 520 525 Leu Asp Tyr Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala 530 535 540 Gly Leu Arg Tyr Arg Ser Met Ile Leu Gly Asn Gly Arg Tyr Val Pro 545 550 555 560 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu 565 570 575 Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val 580 585 590 Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly 595 600 605 Ala Ser Ile Lys Phe Asp Ser Ile Thr Leu Tyr Ala Thr Phe Phe Pro 610 615 620 Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp 625 630 635 640 Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Gly Ala Asn Met Leu 645 650 655 Tyr Pro Ile Pro Ala Lys Ala Thr Asn Val Pro Ile Ser Ile Pro Ser 660 665 670 Arg Asn Trp Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr 675 680 685 Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr 690 695 700 Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr 705 710 715 720 Phe Lys Lys Ile Ser Ile Met Tyr Asp Ser Ser Val Ser Trp Pro Gly 725 730 735 Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Ala Val 740 745 750 Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp 755 760 765 Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe 770 775 780 Tyr Ile Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 785 790 795 800 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Thr Asn Tyr Lys Asp 805 810 815 Tyr Gln Ala Ile Gly Ile Thr His Gln His Asn Asn Ser Gly Phe Val 820 825 830 Gly Tyr Leu Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn 835 840 845 Phe Pro Tyr Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Val Thr Gln 850 855 860 Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser 865 870 875 880 Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu 885 890 895 Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro 900 905 910 Met Asp Glu Pro Thr Leu Leu Tyr Ile Val Phe Glu Val Phe Asp Val 915 920 925 Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu 930 935 940 Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 51 <211> 651 <212> PRT <213> Great Ape Adenovirus <400> 51 Met Arg Arg Ala Ala Met Phe Glu Glu Gly Pro Pro Pro Ser Tyr Glu 1 5 10 15 Ser Ala Met Gly Ile Ser Pro Ala Ala Pro Leu Gln Pro Pro Tyr Val 20 25 30 Pro Pro Arg Tyr Leu Gln Pro Thr Gly Gly Arg Asn Ser Ile Cys Tyr 35 40 45 Ser Glu Leu Gln Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp 50 55 60 Asn Lys Ser Ala Asp Val Ala Ser Leu Asn Tyr Gln Asn Asp His Ser 65 70 75 80 Asp Phe Leu Thr Thr Val Ile Gln Asn Asn Asp Phe Thr Pro Thr Glu 85 90 95 Ala Ser Thr Gln Thr Ile Asn Leu Asp Asn Arg Ser Asn Trp Gly Gly 100 105 110 Asp Leu Lys Thr Ile Leu His Thr Asn Met Pro Asn Val Asn Glu Phe 115 120 125 Met Phe Thr Asn Ser Phe Lys Ala Arg Val Met Val Ala Arg Glu Gln 130 135 140 Gly Glu Ala Lys Tyr Glu Trp Val Asp Phe Thr Leu Pro Glu Gly Asn 145 150 155 160 Tyr Ser Glu Thr Met Thr Leu Asp Leu Met Asn Asn Ala Ile Val Glu 165 170 175 His Tyr Leu Lys Val Gly Arg Gln Asn Gly Val Lys Glu Ser Asp Ile 180 185 190 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 195 200 205 Thr Gly Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 210 215 220 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Gln Ser Arg 225 230 235 240 Leu Ser Asn Leu Leu Gly Val Arg Lys Arg Gln Pro Phe Gln Glu Gly 245 250 255 Phe Lys Ile Thr Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 260 265 270 Leu Asp Leu Asp Ala Tyr Glu Glu Ser Leu Lys Pro Glu Glu Ser Ala 275 280 285 Gly Asp Ser Gly Glu Ser Gly Glu Glu Gln Ala Gly Gly Gly Gly Ser 290 295 300 Ala Ser Val Glu Asn Glu Ser Thr Pro Ala Val Ala Ala Asp Ala Ala 305 310 315 320 Glu Val Glu Pro Glu Ala Met Gln Gln Asp Ala Glu Glu Gly Ala Gln 325 330 335 Glu Asp Met Asn Asn Gly Glu Ile Arg Gly Asp Thr Phe Ala Thr Arg 340 345 350 Gly Glu Glu Lys Glu Ala Glu Ala Ala Ala Ala Thr Ala Glu Ala Glu 355 360 365 Thr Glu Ala Glu Ala Glu Pro Glu Thr Glu Val Met Glu Asp Met Asn 370 375 380 Asp Gly Glu Arg Arg Gly Asp Thr Phe Ala Thr Arg Gly Glu Glu Lys 385 390 395 400 Ala Ala Glu Ala Glu Ala Ala Ala Glu Glu Ala Ala Ala Ala Ala Ala 405 410 415 Lys Ala Glu Ala Ala Ala Glu Ala Lys Val Glu Ala Asp Val Ala Val 420 425 430 Glu Ala Gln Ala Glu Glu Glu Ala Ala Ala Glu Ala Val Lys Glu Lys 435 440 445 Ala Gln Ala Glu Gln Glu Glu Lys Lys Pro Val Ile Gln Pro Leu Lys 450 455 460 Glu Asp Ser Lys Lys Arg Ser Tyr Asn Val Ile Glu Gly Ser Thr Phe 465 470 475 480 Thr Gln Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Val 485 490 495 Lys Gly Val Arg Ser Trp Thr Leu Leu Cys Thr Pro Asp Val Thr Cys 500 505 510 Gly Ser Glu Gln Met Tyr Trp Ser Leu Pro Asn Met Met Gln Asp Pro 515 520 525 Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Phe Pro Val Val Gly 530 535 540 Ala Glu Leu Leu Pro Val His Ser Lys Ser Phe Tyr Asn Glu Gln Ala 545 550 555 560 Val Tyr Ser Gln Leu Ile Arg Gln Ala Thr Ser Leu Thr His Val Phe 565 570 575 Asn Arg Phe Pro Glu Asn Gln Ile Leu Ala Arg Pro Pro Ala Pro Thr 580 585 590 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 595 600 605 Leu Pro Leu Arg Asn Ser Ile Ser Gly Val Gln Arg Val Thr Ile Thr 610 615 620 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 625 630 635 640 Val Ser Pro Arg Val Leu Ser Ser Arg Thr Phe 645 650 <210> 52 <211> 651 <212> PRT <213> Great Ape Adenovirus <400> 52 Met Arg Arg Ala Ala Met Phe Glu Glu Gly Pro Pro Pro Ser Tyr Glu 1 5 10 15 Ser Ala Met Gly Ile Ser Pro Ala Ala Pro Leu Gln Pro Pro Tyr Val 20 25 30 Pro Pro Arg Tyr Leu Gln Pro Thr Gly Gly Arg Asn Ser Ile Cys Tyr 35 40 45 Ser Glu Leu Gln Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp 50 55 60 Asn Lys Ser Ala Asp Val Ala Ser Leu Asn Tyr Gln Asn Asp His Ser 65 70 75 80 Asp Phe Leu Thr Thr Val Ile Gln Asn Asn Asp Phe Thr Pro Thr Glu 85 90 95 Ala Ser Thr Gln Thr Ile Asn Leu Asp Asn Arg Ser Asn Trp Gly Gly 100 105 110 Asp Leu Lys Thr Ile Leu His Thr Asn Met Pro Asn Val Asn Glu Phe 115 120 125 Met Phe Thr Asn Ser Phe Lys Ala Arg Val Met Val Ala Arg Glu Gln 130 135 140 Gly Glu Ala Lys Tyr Glu Trp Val Asp Phe Thr Leu Pro Glu Gly Asn 145 150 155 160 Tyr Ser Glu Thr Met Thr Leu Asp Leu Met Asn Asn Ala Ile Val Glu 165 170 175 His Tyr Leu Lys Val Gly Arg Gln Asn Gly Val Lys Glu Ser Asp Ile 180 185 190 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 195 200 205 Thr Gly Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 210 215 220 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Gln Ser Arg 225 230 235 240 Leu Ser Asn Leu Leu Gly Val Arg Lys Arg Gln Pro Phe Gln Glu Gly 245 250 255 Phe Lys Ile Thr Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 260 265 270 Leu Asp Leu Asp Ala Tyr Glu Glu Ser Leu Lys Pro Glu Glu Ser Ala 275 280 285 Gly Asp Ser Gly Glu Ser Gly Glu Glu Gln Ala Gly Gly Gly Gly Ser 290 295 300 Ala Ser Val Glu Asn Glu Ser Thr Pro Ala Val Ala Ala Asp Ala Ala 305 310 315 320 Glu Val Glu Pro Glu Ala Met Gln Gln Asp Ala Glu Glu Gly Ala Gln 325 330 335 Glu Asp Met Asn Asn Gly Glu Ile Arg Gly Asp Thr Phe Ala Thr Arg 340 345 350 Gly Glu Glu Lys Glu Ala Glu Ala Ala Ala Ala Thr Ala Glu Ala Glu 355 360 365 Thr Glu Ala Glu Ala Glu Pro Glu Thr Glu Val Met Glu Asp Met Asn 370 375 380 Asp Gly Glu Arg Arg Gly Asp Thr Phe Ala Thr Arg Gly Glu Glu Lys 385 390 395 400 Ala Ala Glu Ala Glu Ala Ala Ala Glu Glu Ala Ala Ala Ala Ala Ala 405 410 415 Lys Ala Glu Ala Ala Ala Glu Ala Lys Val Glu Ala Asp Val Ala Val 420 425 430 Glu Ala Gln Ala Glu Glu Glu Ala Ala Thr Glu Ala Val Lys Glu Lys 435 440 445 Ala Gln Ala Glu Gln Glu Glu Lys Lys Pro Val Ile Gln Pro Leu Lys 450 455 460 Glu Asp Ser Lys Lys Arg Ser Tyr Asn Val Ile Glu Gly Ser Thr Phe 465 470 475 480 Thr Gln Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Val 485 490 495 Lys Gly Val Arg Ser Trp Thr Leu Leu Cys Thr Pro Asp Val Thr Cys 500 505 510 Gly Ser Glu Gln Met Tyr Trp Ser Leu Pro Asn Met Met Gln Asp Pro 515 520 525 Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Phe Pro Val Val Gly 530 535 540 Ala Glu Leu Leu Pro Val His Ser Lys Ser Phe Tyr Asn Glu Gln Ala 545 550 555 560 Val Tyr Ser Gln Leu Ile Arg Gln Ala Thr Ser Leu Thr His Val Phe 565 570 575 Asn Arg Phe Pro Glu Asn Gln Ile Leu Ala Arg Pro Pro Ala Pro Thr 580 585 590 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 595 600 605 Leu Pro Leu Arg Asn Ser Ile Ser Gly Val Gln Arg Val Thr Ile Thr 610 615 620 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 625 630 635 640 Val Ser Pro Arg Val Leu Ser Ser Arg Thr Phe 645 650 <210> 53 <211> 598 <212> PRT <213> Great Ape Adenovirus <400> 53 Met Ser Asp Ser Ser Ser Cys Pro Ser Ala Pro Thr Ile Phe Met Leu 1 5 10 15 Leu Gln Met Lys Arg Ala Arg Ser Ser Asp Glu Thr Phe Asn Pro Val 20 25 30 Tyr Pro Tyr Asp Thr Glu Ile Ala Pro Thr Ser Val Pro Phe Leu Thr 35 40 45 Pro Pro Phe Val Ser Ser Ala Gly Met Gln Glu Asn Pro Ala Gly Val 50 55 60 Leu Ser Leu His Leu Ser Glu Pro Leu Thr Thr His Asn Gly Ala Leu 65 70 75 80 Thr Leu Lys Met Gly Gly Gly Leu Thr Leu Asp Lys Glu Gly Asn Leu 85 90 95 Thr Ser Gln Asn Ile Thr Ser Val Asp Pro Pro Leu Lys Lys Ser Lys 100 105 110 Asn Asn Ile Ser Leu Gln Thr Ala Ala Pro Leu Ala Val Ser Ser Gly 115 120 125 Ala Leu Thr Leu Phe Ala Thr Pro Pro Leu Ala Val Ser Gly Asp Asn 130 135 140 Leu Thr Val Gln Ser Gln Ala Pro Leu Thr Leu Glu Asp Ser Lys Leu 145 150 155 160 Thr Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Val 165 170 175 Leu Glu Thr Glu Pro Pro Leu His Ala Ser Asp Ser Ser Ser Leu Gly 180 185 190 Leu Ser Val Thr Ala Pro Leu Ser Ile Asn Asn Asp Ser Leu Gly Leu 195 200 205 Asp Met Gln Ala Pro Ile Ser Ser Arg Asp Gly Lys Leu Ala Leu Thr 210 215 220 Val Ala Ala Pro Leu Thr Val Ala Glu Gly Ile Asn Ala Leu Ala Val 225 230 235 240 Ala Thr Gly Asn Gly Ile Gly Leu Asn Glu Thr Asn Thr His Leu Gln 245 250 255 Ala Lys Leu Val Ala Pro Leu Gly Phe Asp Thr Asn Gly Asn Ile Lys 260 265 270 Leu Ser Val Ala Gly Gly Met Arg Leu Asn Asn Asn Thr Leu Ile Leu 275 280 285 Asp Val Asn Tyr Pro Phe Glu Ala Gln Gly Gln Leu Ser Leu Arg Val 290 295 300 Gly Ser Gly Pro Leu Tyr Val Asp Ser Ser Ser His Asn Leu Thr Ile 305 310 315 320 Arg Cys Leu Arg Gly Leu Tyr Val Thr Ser Ser Asn Asn Gln Asn Gly 325 330 335 Leu Glu Ala Asn Ile Lys Leu Thr Lys Gly Leu Val Tyr Asp Gly Asn 340 345 350 Ala Ile Ala Val Asn Val Gly Lys Gly Leu Glu Tyr Ser Pro Thr Gly 355 360 365 Thr Thr Glu Lys Pro Ile Gln Thr Lys Ile Gly Leu Gly Met Glu Tyr 370 375 380 Asp Thr Glu Gly Ala Met Met Thr Lys Leu Gly Ser Gly Leu Ser Phe 385 390 395 400 Asp Asn Ser Gly Ala Ile Val Val Gly Asn Lys Asn Asp Asp Arg Leu 405 410 415 Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Ile Tyr Ser 420 425 430 Glu Lys Asp Ala Lys Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln 435 440 445 Val Val Gly Thr Val Ser Ile Ala Ala Leu Lys Gly Ser Leu Val Pro 450 455 460 Ile Thr Ser Ala Ile Ser Val Val Gln Ile Tyr Leu Arg Phe Asp Glu 465 470 475 480 Asn Gly Val Leu Met Ser Asn Ser Ser Leu Asn Gly Glu Tyr Trp Asn 485 490 495 Phe Arg Asn Gly Asp Ser Thr Asn Gly Thr Pro Tyr Thr Asn Ala Val 500 505 510 Gly Phe Met Pro Asn Leu Leu Ala Tyr Pro Lys Gly Gln Thr Thr Thr 515 520 525 Ala Lys Ser Asn Ile Val Ser Gln Val Tyr Met Asn Gly Asp Asp Thr 530 535 540 Lys Pro Met Thr Phe Thr Ile Asn Phe Asn Gly Leu Ser Glu Thr Gly 545 550 555 560 Asp Thr Pro Val Ser Lys Tyr Ser Met Thr Phe Ser Trp Arg Trp Pro 565 570 575 Asn Gly Ser Tyr Ile Gly His Asn Phe Val Thr Asn Ser Phe Thr Phe 580 585 590 Ser Tyr Ile Ala Gln Glu 595 <210> 54 <211> 602 <212> PRT <213> Great Ape Adenovirus <400> 54 Met Ser Asp Ser Ser Ser Ser Cys Pro Ser Ala Pro Thr Ile Phe Met 1 5 10 15 Leu Leu Gln Met Lys Arg Ala Arg Ser Ser Asp Glu Thr Phe Asn Pro 20 25 30 Val Tyr Pro Tyr Asp Thr Glu Ile Ala Pro Thr Ser Val Pro Phe Leu 35 40 45 Thr Pro Pro Phe Val Ser Pro Ala Gly Met Gln Glu Asn Pro Ala Gly 50 55 60 Val Leu Ser Leu His Leu Ser Glu Pro Leu Thr Thr His Asn Gly Ala 65 70 75 80 Leu Thr Leu Lys Met Gly Gly Gly Leu Ile Leu Asp Lys Glu Gly Asn 85 90 95 Leu Thr Ser Gln Asn Ile Thr Ser Val Asp Pro Pro Leu Lys Lys Ser 100 105 110 Lys Asn Asn Ile Ser Leu Gln Thr Ala Ala Pro Leu Ala Val Ser Ser 115 120 125 Gly Ala Leu Thr Leu Phe Ala Thr Pro Pro Leu Ala Val Ser Gly Asp 130 135 140 Asn Leu Thr Val Gln Ser Gln Ala Pro Leu Thr Leu Glu Asp Ser Lys 145 150 155 160 Leu Thr Leu Ala Thr Lys Gly Pro Leu Thr Val Ser Glu Gly Lys Leu 165 170 175 Val Leu Glu Thr Glu Ala Pro Leu His Ala Ser Asp Ser Ser Ser Leu 180 185 190 Gly Leu Ser Val Thr Ala Pro Leu Ser Ile Asn Asn Asp Ser Leu Gly 195 200 205 Leu Asp Leu Gln Ala Pro Ile Val Ser Gln Asn Gly Lys Leu Ala Leu 210 215 220 Asn Ile Ala Gly Pro Leu Ala Val Ala Asp Ser Ile Asn Ala Leu Thr 225 230 235 240 Val Gly Thr Gly Lys Gly Ile Gly Leu Asn Glu Thr Ser Thr His Leu 245 250 255 Gln Ala Lys Leu Val Ala Pro Leu Gly Phe Asp Thr Asn Gly Asn Ile 260 265 270 Lys Leu Ser Val Ala Gly Gly Met Arg Leu Asn Asn Asp Thr Leu Ile 275 280 285 Leu Asp Val Asn Tyr Pro Phe Glu Ala Gln Gly Gln Leu Ser Leu Arg 290 295 300 Val Gly Thr Gly Pro Leu Tyr Val Asp Ser Ser Ser His Asn Leu Thr 305 310 315 320 Ile Arg Cys Leu Arg Gly Leu Tyr Ile Thr Ser Ser Asn Asn Gln Asn 325 330 335 Gly Leu Glu Ala Asn Ile Lys Leu Thr Lys Gly Leu Val Tyr Glu Gly 340 345 350 Asn Ala Ile Ala Val Asn Val Gly Gln Gly Leu Gln Tyr Ser Thr Thr 355 360 365 Ala Thr Ser Glu Gly Val Tyr Pro Ile Gln Ser Lys Ile Gly Leu Gly 370 375 380 Met Glu Tyr Asp Thr Asn Gly Ala Met Met Ala Lys Leu Gly Ser Gly 385 390 395 400 Leu Ser Phe Asp Asn Ser Gly Ala Ile Val Val Gly Asn Lys Asn Asp 405 410 415 Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Arg 420 425 430 Ile Tyr Ser Glu Lys Asp Thr Lys Leu Thr Leu Val Leu Thr Lys Cys 435 440 445 Gly Ser Gln Ile Leu Gly Thr Val Ser Ala Leu Ala Val Arg Gly Ser 450 455 460 Leu Ala Pro Ile Thr Asn Ala Ser Ser Ile Val Gln Ile Phe Leu Arg 465 470 475 480 Phe Asp Glu Asn Gly Leu Leu Met Ser Asn Ser Ser Leu Asp Gly Asp 485 490 495 Tyr Trp Asn Tyr Arg Asn Gly Asp Ser Thr Asn Gly Thr Pro Tyr Thr 500 505 510 Asn Ala Val Gly Phe Met Pro Asn Leu Ala Ala Tyr Pro Lys Gly Gln 515 520 525 Ala Thr Thr Ala Lys Ser Ser Ile Val Ser Gln Val Tyr Met Asp Gly 530 535 540 Asp Thr Thr Lys Pro Ile Thr Leu Lys Ile Asn Phe Asn Gly Ile Asp 545 550 555 560 Glu Thr Thr Glu Asn Thr Pro Val Ser Lys Tyr Ser Met Thr Phe Ser 565 570 575 Trp Ser Trp Pro Thr Ala Ser Tyr Ile Gly His Thr Phe Ala Thr Asn 580 585 590 Ser Phe Thr Phe Ser Tyr Ile Ala Gln Glu 595 600 <210> 55 <211> 168 <212> DNA <213> Great Ape Adenovirus <400> 55 agggctttcg ttctgtagcc tggaggaaag taaatgggtt gggttgcggt gtgccccggt 60 tcgagaccaa gctgagctca gccggctgaa gccgcagcta acgtggtatt ggcagtcccg 120 tctcgaccca ggccctgtat cctccaggat acggtcgaga gccctttt 168 <210> 56 <211> 168 <212> DNA <213> Great Ape Adenovirus <400> 56 agggctttcg ttctgtagcc tggaggaaag taaatgggtt gggttgcggt gtgccccggt 60 tcgagaccaa gctgagctcg gccggctgaa gccgcagcta acgtggtatt ggcagtcccg 120 tctcgaccca ggccctgtat cctccaggat acggtcgaga gccctttt 168 <210> 57 <211> 174 <212> DNA <213> Great Ape Adenovirus <400> 57 ggctcgcttc cgtagtctgg agaaacaatc gccagggttg cgttgcggcg taccccggtt 60 cgagccccta tggcggcttg gatcggccgg aaccgcggct aacgtgggct gtggcagccc 120 cgtcctcagg accccgccag ccgacttctc cagttacggg agcgagcccc tttt 174 <210> 58 <211> 104 <212> DNA <213> Artificial Sequence <220> <223> FW primer GAd-GAG left end <400> 58 gaactccgaa ttcgtttaaa ccatcatcaa taatatacct tattttggat tgaggccaat 60 atgataatga ggtgggcggg gcgaggcggg gcgggtgacg tagg 104 <210> 59 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> RV primer GAd-GAG left end <400> 59 cataatcggc cgcagcggcc cgtcagatga cggcgacaat aaa 43 <210> 60 <211> 37 <212> DNA <213> Artificial Sequence <220> <223> FW primer GAd right end <400> 60 cataatcgac ccgagtcgca ctctcacagc accagca 37 <210> 61 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> RV primer GAd right end <400> 61 gaactccgga tccgtttaaa ccatcatcaa taatatacct tattttg 47 <210> 62 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> FW primer pIX <400> 62 cataatcgcg atcgcgctta ggcctgacca tctgg 35 <210> 63 <211> 34 <212> DNA <213> Artificial Sequence <220> <223> RV primer pIX <400> 63 gaactccggc gcgccttagg gggaggcaag gctg 34 <210> 64 <211> 55 <212> DNA <213> Artificial Sequence <220> <223> FW primer Amp-LacZ-SacB Ex. 2 <400> 64 gaactccggc gcgcctaggg ataacagggt aataccccta tttgtttatt tttct 55 <210> 65 <211> 56 <212> DNA <213> Artificial Sequence <220> <223> RV primer Amp-LacZ-SacB Ex. 2 <400> 65 cataatcggc gcgccattac cctgttatcc ctattatttg ttaactgtta attgtc 56 <210> 66 <211> 92 <212> DNA <213> Artificial Sequence <220> <223> FW primer Amp-LacZ-SacB Ex. 4 <400> 66 ggattacacc aagatctttg ctgtcatttg tgtgctgagt ataataaagg ctgagatcag 60 aatctactcg acccctattt gtttattttt ct 92 <210> 67 <211> 93 <212> DNA <213> Artificial Sequence <220> <223> RV primer Amp-LacZ-SacB Ex. 4 <400> 67 cttgctatca gatttcaagt aagtgatttt ttattgatta cagttatgat caattgaaag 60 ggataaggtc ttatttgtta actgttaatt gtc 93 <210> 68 <211> 100 <212> DNA <213> Artificial Sequence <220> <223> SS oligo Amp-LacZ-SacB <400> 68 ctgtcatttg tgtgctgagt ataataaagg ctgagatcag aatctactcg gaccttatcc 60 ctttcaattg atcataactg taatcaataa aaaatcactt 100 <210> 69 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> CMVfw <400> 69 catctacgta ttagtcatcg ctattacca 29 <210> 70 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> CMVrv <400> 70 gacttggaaa tccccgtgag t 21 <210> 71 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> CMVFAM-TAMRA probe <400> 71 acatcaatgg gcgtggatag cggtt 25 <210> 72 <211> 33360 <212> DNA <213> Artificial Sequence <220> <223> GADNOU19 GAG (DE1DE3) <400> 72 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg ggccgccatt gcatacgttg 480 tatccatatc ataatatgta catttatatt ggctcatgtc caacattacc gccatgttga 540 cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca 600 tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac 660 gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact 720 ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa 780 gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg 840 cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta 900 gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg 960 tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg 1020 caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg 1080 ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctctccctat cagtgataga 1140 gatctcccta tcagtgatag agatcgtcga cgagctcgtt tagtgaaccg tcagatcgcc 1200 tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg atccagcctc 1260 cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga gatctaccat 1320 gggtgctagg gcttctgtgc tgtctggtgg tgagctggac aagtgggaga agatcaggct 1380 gaggcctggt ggcaagaaga agtacaagct aaagcacatt gtgtgggcct ccagggagct 1440 ggagaggttt gctgtgaacc ctggcctgct ggagacctct gaggggtgca ggcagatcct 1500 gggccagctc cagccctccc tgcaaacagg ctctgaggag ctgaggtccc tgtacaacac 1560 agtggctacc ctgtactgtg tgcaccagaa gattgatgtg aaggacacca aggaggccct 1620 ggagaagatt gaggaggagc agaacaagtc caagaagaag gcccagcagg ctgctgctgg 1680 cacaggcaac tccagccagg tgtcccagaa ctaccccatt gtgcagaacc tccagggcca 1740 gatggtgcac caggccatct ccccccggac cctgaatgcc tgggtgaagg tggtggagga 1800 gaaggccttc tcccctgagg tgatccccat gttctctgcc ctgtctgagg gtgccacccc 1860 ccaggacctg aacaccatgc tgaacacagt ggggggccat caggctgcca tgcagatgct 1920 gaaggagacc atcaatgagg aggctgctga gtgggacagg ctgcatcctg tgcacgctgg 1980 ccccattgcc cccggccaga tgagggagcc caggggctct gacattgctg gcaccacctc 2040 caccctccag gagcagattg gctggatgac caacaacccc cccatccctg tgggggaaat 2100 ctacaagagg tggatcatcc tgggcctgaa caagattgtg aggatgtact cccccacctc 2160 catcctggac atcaggcagg gccccaagga gcccttcagg gactatgtgg acaggttcta 2220 caagaccctg agggctgagc aggcctccca ggaggtgaag aactggatga cagagaccct 2280 gctggtgcag aatgccaacc ctgactgcaa gaccatcctg aaggccctgg gccctgctgc 2340 caccctggag gagatgatga cagcctgcca gggggtgggg ggccctggtc acaaggccag 2400 ggtgctggct gaggccatgt cccaggtgac caactccgcc accatcatga tgcagagggg 2460 caacttcagg aaccagagga agacagtgaa gtgcttcaac tgtggcaagg tgggccacat 2520 tgccaagaac tgtagggccc ccaggaagaa gggctgctgg aagtgtggca aggagggcca 2580 ccagatgaag gactgcaatg agaggcaggc caacttcctg ggcaaaatct ggccctccca 2640 caagggcagg cctggcaact tcctccagtc caggcctgag cccacagccc ctcccgagga 2700 gtccttcagg tttggggagg agaagaccac ccccagccag aagcaggagc ccattgacaa 2760 ggagctgtac cccctggcct ccctgaggtc cctgtttggc aacgacccct cctcccagta 2820 aaataaagcc catcagaatt cagtcgacag cggccgcgat ctgctgtgcc ttctagttgc 2880 cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc 2940 actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct 3000 attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg 3060 catgctgggg atgcggtggg ctctatggcc gggccgcgat cgcgcttagg cctgaccatc 3120 tggtgctggc ctgcaccagg gccgagtttg ggtctagcga tgaggatacc gattgaggtg 3180 ggtaaggtgg gcgtggctag cagggtgggc gtgtataaat tgggggtcta aggggtctct 3240 ctgtttgtct tgcaacagcc gccgccatga gcgacaccgg caacagcttt gatggaagca 3300 tctttagtcc ctatctgaca gtgcgcatgc ctcactgggc cggagtgcgt cagaatgtga 3360 tgggttccaa cgtggatgga cgtcccgttc tgccttcaaa ttcgtctact atggcctacg 3420 cgaccgtggg aggaactccg ctggacgccg cgacctccgc cgccgcctcc gccgccgccg 3480 cgaccgcgcg cagcatggct acggaccttt acagctcttt ggtggcgagc agcgcggcct 3540 ctcgcgcgtc tgctcgggat gagaaactga ctgctctgct gcttaaactg gaagacttga 3600 cccgggagct gggtcaactg acccagcagg tttccagctt gcgtgagagc agccttgcct 3660 ccccctaatg gcccataata taaataaaag ccagtctgtt tggattaagc aagtgtatgt 3720 tctttattta actctccgcg cgcggtaagc ccgggaccag cggtctcggt cgtttagggt 3780 gcggtggatt ttttccaaca cgtggtacag gtggctctgg atgtttagat acatgggcat 3840 gagtccatcc ctggggtgga ggtagcacca ctgcagagct tcgtgctcgg gggtggtgtt 3900 gtatatgatc cagtcgtagc aggagcgctg ggcgtggtgc tgaaaaatgt ccttaagcaa 3960 gaggcttata gctaggggga ggcccttggt gtaagtgttt acaaatctgc ttagctggga 4020 ggggtgcatc cggggggata tgatgtgcat cttggactgg atttttaggt tggctatgtt 4080 cccgcccaga tcccttctgg gattcatgtt gtgcaggacc accagcacgg tatatccagt 4140 gcacttggga aatttatcgt ggagcttaga cgggaatgca tggaagaact tggagacgcc 4200 cttgtggcct cccagatttt ccatacattc gtccatgatg atggcaatgg gcccgtggga 4260 agctgcctga gcaaaaacgt ttctggcatc gctcacatcg tagttatgtt ccagggtgag 4320 gtcatcatag gacatcttta cgaatcgggg gcgaagggtc ccggactggg ggatgatggt 4380 accctcgggc cccggggcgt agttcccctc acagatctgc atctcccagg ctttcatttc 4440 agagggaggg atcatatcca cctgcggggc gatgaaaaag acagtttctg gcgcagggga 4500 gattaactgg gatgagagca ggtttctgag cagctgtgac tttccacagc cggtgggccc 4560 atatatcacg cctatcaccg gctgcagctg gtagttaaga gagctgcagc tgccgtcctc 4620 ccggagcagg ggggccacct cgttgagcat atccctgacg tggatgttct ccctgaccag 4680 ttccgccaga aggcgctcgc cgcccagcga aagcagctct tgcaaggaag caaaattttt 4740 cagcggtttc aggccatcgg ccgtgggcat gtttttcagc gtctgggtca gcagctccag 4800 cctgtcccag agctcggtga tgtgctctac ggcatctcga tccagcagat ctcctcgttt 4860 cgcgggttgg ggcggctttc gctgtagggc accagccgat gggcgtccag cggggccaga 4920 gtcatgtcct tccatgggcg cagggtcctc gtcagggtgg tctgggtcac ggtgaagggg 4980 tgcgctccgg gttgggcact ggccagggtg cgcttgaggc tggttctgct ggtgctgaat 5040 cgctgccgct cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt ctcgtagtcg 5100 agaccctcgg cggcgtgccc cttggcgcgg agctttccct tggaggtggc gccgcacgag 5160 gggcactgca ggctcttcag ggcgtagagc ttgggagcga gaaacacgga ctctggggag 5220 taggcgtccg cgccgcaggc cgagcagacc gtctcgcatt ccaccagcca agtgagttcc 5280 gggcggtcag ggtcaaaaac caggttgccc ccatgctttt tgatgcgttt cttaccttgg 5340 ctctccatga ggcggtgtcc cttctcggtg acgaagaggc tgtccgtgtc cccgtagacc 5400 gacttcaggg gcctgtcttc cagcggagtg cctctgtcct cctcgtagag aaactctgac 5460 cactctgaga cgaaggcccg cgtccaggcc aggacgaagg aggccacgtg ggaggggtag 5520 cggtcgttgt ccactagcgg gtccaccttc tccagggtgt gcaggcacat gtccccctcc 5580 tccgcgtcca gaaaagtgat tggcttgtag gtgtaggaca cgtgaccggg ggttcccaac 5640 gggggggtat aaaagggggt gggtgccctt tcatcttcac tctcttccgc atcgctgtct 5700 gcgagagcca gctgctgggg taagtattcc ctctcgaagg cgggcatgac ctcagcgctc 5760 aggttgtcag tttctaaaaa tgaggaggat ttgatgttca cctgtccgga ggtgatacct 5820 ttgagggtac ctgggtccat ctggtcagaa aacactattt ttttgttatc aagcttggtg 5880 gcgaatgacc cgtagagggc gttggagagc agcttggcga tggagcgcag ggtctggttt 5940 ttgtcgcggt cggctcgctc cttggccgcg atgttgagtt gcacgtactc gcgggccacg 6000 cacttccact cggggaacac ggtggtgcgc tcgtctggga tcaggcgcac cctccagccg 6060 cggttgtgca gggtgaccat gtcgacgctg gtggcgacct caccgcgcag acgctcgttg 6120 gtccagcaga ggcggccgcc cttgcgcgag cagaaggggg gtagggggtc cagctggtcc 6180 tcgtttgggg ggtccgcgtc gatggtaaag accccgggga gcaggcgcgg gtcaaagtag 6240 tcgatcttgc aagcttgcat gtccagagcc cgctgccatt cgcgggcggc gagcgcgcgc 6300 tcgtaggggt tgaggggcgg gccccagggc atggggtggg tgagcgcgga ggcgtacatg 6360 ccgcagatgt catacacgta caggggttcc ctgaggatac cgaggtaggt ggggtagcag 6420 cgccccccgc ggatgctggc gcgcacgtag tcatagagct cgtgggaggg ggccagcatg 6480 ttgggcccga ggttggtgcg ctgggggcgc tcggcgcgga agacgatctg cctgaagatg 6540 gcgtgggagt tggaggagat ggtgggccgc tggaagacgt tgaagcttgc ttcttgcaag 6600 cccacggagt ccctgacgaa ggaggcgtag gactcgcgca gcttgtgcac cagctcggcg 6660 gtgacctgga cgtcgagcgc acagtagtcg agggtctcgc ggatgatgtc atacctatcc 6720 tcccccttct ttttccacag ctcgcggttg aggacgaact cttcgcggtc tttccagtac 6780 tcttggaggg gaaacccgtc cgtgtccgaa cggtaagagc ctagcatgta gaactggttg 6840 acggcctggt aggggcagca gcccttctcc acgggcagcg cgtaggcctg cgccgccttg 6900 cggagggagg tgtgggtgag ggcgaaagtg tccctgacca tgactttgag gtattgatgt 6960 ctgaagtctg tgtcatcgca gccgccctgt tcccacaggg tgtagtccgt gcgctttttg 7020 gagcgcgggt tgggcaggga gaaggtgagg tcattgaaga ggatcttccc cgctcgaggc 7080 atgaagtttc tggtgatgcg aaagggccct gggaccgagg agcggttgtt gatgacctgg 7140 gcggccagga cgatctcgtc aaagccgttt atgttgtgtc ccacgatgta gagctccagg 7200 aagcggggct ggcccttgat ggaggggagc tttttaagtt cctcgtaggt aagctcctcg 7260 ggcgattcca ggccgtgctc ctccagggcc cagtcttgca agtgagggtt ggccgccagg 7320 aaggatcgcc agaggtcgcg ggccatgagg gtctgcaggc ggtcgcggaa ggttctgaac 7380 tgccgcccca cggccatttt ttcgggggtg atgcagtaga aggtgagggg gtctttctcc 7440 caggggtccc atctgagctc tcgggcgagg tcgcgcgcgg cagcgaccag agcctcgtcg 7500 ccccccagtt tcatgaccag catgaagggc acgagttgct tgccaaaggc tcccatccaa 7560 gtgtaggttt ctacatcgta ggtgacaaag aggcgctccg tgcgaggatg agagccgatt 7620 gggaagaact ggatctcccg ccaccagttg gaggattggc tgttgatgtg gtgaaagtag 7680 aagtcccgtc tgcgggccga gcactcgtgc tggcttttgt aaaagcgacc gcagtactgg 7740 cagcgctgca cgggttgtat atcttgcacg aggtgaacct ggcgacctct gacgaggaag 7800 cgcagcggga atctaagtcc cccgcctggg gtcccgtgtg gctggtggtc ttttactttg 7860 gttgtctggc cgccagcatc tgtctcctgg agggcgatgg tggaacagac caccacgccg 7920 cgagagccgc aggtccagat ctcggcgctc ggcgggcgga gtttgatgac gacatcgcgc 7980 acattggagc tgtccatggt ctccagctcc cgcggcggca ggtcagccgg gagttcctgg 8040 aggttcacct cgcagagacg ggtcaaggcg cggacagtgt tgagatggta tctgatttca 8100 aggggcatgt tggaggcgga gtcgatggct tgcaggaggc cgcagccccg gggggccacg 8160 atggttcccc gcggggcgcg aggggaggcg gaagctgggg gtgtgttcag aagcggtgac 8220 gcgggcgggc ccccggaggt agggggggtt ccggccccac aggcatgggc ggcaggggca 8280 cgtcttcgcc gcgcgcgggc aggggctggt gctggctccg aagagcgctt gcgtgcgcga 8340 cgacgcgacg gttggtgtcc tgtatctggc gcctctgagt gaagaccacg ggtcccgtga 8400 ccttgaacct gaaagagagt tcgacagaat caatctcggc atcgttgaca gcggcctggc 8460 gcaggatctc ctgcacgtcg cccgagttgt cctggtaggc gatttctgcc atgaactgct 8520 cgatctcttc ctcctggaga tctcctcgtc cggcgcgctc cacggtggcc gccaggtcgt 8580 tggagatgcg acccatgagc tgcgagaagg cgttgagtcc gccctcgttc cagacccggc 8640 tgtagaccac gcccccctcg gcgtcgcggg cgcgcatgac cacctgggcc aggttgagct 8700 ccacgtgtcg cgtgaagacg gcgtagttgc gcaggcgctg gaaaaggtag ttcagggtgg 8760 tggcggtgtg ctcggcgacg aagaagtaca tgacccagcg ccgcaacgtg gattcattga 8820 tgtcccccaa ggcctccagg cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa 8880 actgggagtt gcgagcggac acggtcaact cctcctccag aagacggatg agctcggcga 8940 cagtgtcgcg cacctcgcgc tcgaaggcca cggggggcgc ttcttcctct tccacctctt 9000 cttccatgat tgcttcttct tcttcctcag ccgggacggg agggggcggc ggcgggggag 9060 gggcgcggcg gcggcggcgg cgcaccggga ggcggtcgat gaagcgctcg atcatctccc 9120 cccgcatgcg gcgcatggtc tcggtgacgg cgcggccgtt ctcccggggg cgcagctcga 9180 agacgccgcc tctcatttcg ccgcggggcg ggcggccgtg aggtagcgag acggcgctga 9240 ctatgcatct taacaattgc tgtgtaggta cgccgccaag ggacctgatt gagtccagat 9300 ccaccggatc cgaaaacctt tggaggaaag cgtctatcca gtcgcagtcg caaggtaggc 9360 tgagcaccgt ggcgggcggg ggcgggtcgg gagagttcct ggcggagatg ctgctgatga 9420 tgtaattaaa gtaggcggtc ttgagaaggc ggatggtgga caggagcacc atgtctttgg 9480 gtccggcctg ttggatgcgg aggcggtcgg ccatgcccca ggcctcgttc tgacaccggc 9540 gcaggtcttt gtagtaatct tgcatgagtc tttccaccgg cacttcttct ccttcctctt 9600 cttcatctcg ccggtggttt ctcgcgccgc ccatgcgcgt gaccccaaag cccctgagcg 9660 gctgcagcag ggccaggtcg gcgaccacgc gctcggccaa gatggcctgc tgtacctgag 9720 tgagggtcct ctcgaagtca tccatgtcca cgaagcggtg gtaggcaccc gtgttgatgg 9780 tgtaggtgca gttggccatg acggaccagt tgacggtctg gtgtcccggc tgcgagagct 9840 ccgtgtaccg caggcgcgag aaggcgcggg aatcgaacac gtagtcgttg caagtccgca 9900 ccagatactg gtagcccacc aggaagtgcg gcggaggttg gcgatagagg ggccagcgct 9960 gggtggcggg ggcgccgggc gccaggtctt ccagcatgag gcggtggtat ccgtagatgt 10020 acctggacat ccaggtgatg cctgcggcgg tggtggtggc gcgcgcgtag tcgcggaccc 10080 ggttccagat gtttcgcagg ggcgagaagt gttccatggt cggcacgctc tggccggtga 10140 ggcgcgcgca gtcgttgacg ctctatacac acacaaaaac gaaagcgttt acagggcttt 10200 cgttctgtag cctggaggaa agtaaatggg ttgggttgcg gtgtgccccg gttcgagacc 10260 aagctgagct cagccggctg aagccgcagc taacgtggta ttggcagtcc cgtctcgacc 10320 caggccctgt atcctccagg atacggtcga gagccctttt gctttcttgg ccaagcgccc 10380 gtggcgcgat ctgggataga tggtcgcgat gagaggacaa aagcggctcg cttccgtagt 10440 ctggagaaac aatcgccagg gttgcgttgc ggcgtacccc ggttcgagcc cctatggcgg 10500 cttggatcgg ccggaaccgc ggctaacgtg ggctgtggca gccccgtcct caggaccccg 10560 ccagccgact tctccagtta cgggagcgag ccccttttgt ttttttattt tttagatgca 10620 tcccgtgctg cggcagatgc gcccctcgcc ccggcccgat cagcagcagc aacagcaggc 10680 atgcagaccc ccctctcctc tccccgcccc ggtcaccacg gccgcggcgg ccgtgtccgg 10740 tgcggggggc gcgctggagt cagatgagcc accgcggcgg cgacctaggc agtatctgga 10800 cttggaagag ggcgagggac tggcgcggct gggggcgagc tctccagagc gccacccgcg 10860 ggtgcagttg aaaagggacg cgcgtgaggc gtacctgccg cggcaaaacc tgtttcgcga 10920 ccgcgggggc gaggagcccg aggagatgcg ggactgcagg ttccaagcgg ggcgcgagct 10980 gcgccgcggc ttggacagac agcgcctgct gcgcgaggag gactttgagc ccgacacgca 11040 gacgggcatc agccccgcgc gcgcgcacgt ggccgcggcc gacctggtga ccgcctacga 11100 gcagacggtg aaccaggagc gcaacttcca aaaaagcttc aacaaccacg tgcgcacgct 11160 ggtggcgcgc gaggaggtga ccctgggtct catgcatctg tgggacctgg tggaggcgat 11220 cgtgcagaac cccagcagca agcccctgac cgcgcagctg ttcctggtgg tgcagcacag 11280 cagggacaac gaggccttca gggaggcgct gctgaacatc accgagccgg aggggcgctg 11340 gctcctggac ctgataaaca tcctgcagag catagtggtg caggagcgca gcctgagcct 11400 ggccgagaag gtggcggcca ttaactattc tatgctgagc ctgggcaagt tctacgctcg 11460 caagatctac aagaccccct acgtgcccat agacaaggag gtgaagatag acagcttcta 11520 catgcgcatg gcgctgaagg tgctaaccct gagcgacgac ctgggagtgt accgcaacga 11580 gcgcatccac aaggccgtga gcgccagccg gcggcgcgag ctgagcgacc gcgaactgat 11640 gcacagtctg cagcgcgcgc tgaccggcgc gggcgagggc gacagggagg tcgagtccta 11700 ctttgacatg ggggccgacc tgcactggca gccgagccgc cgcgccctgg aagcggcggg 11760 ggcgtacggc ggccccctgg cggccgatga cgaggaagag gaggactatg agctagagga 11820 gggcgagtac ctggaggact gacctggctg gtggtgtttt ggtatagatg caagatccga 11880 acgtggcgga cccggcggtc cgggcggcgc tgcagagcca gccgtccggc attaactcct 11940 ctgacgactg ggccgcggcc atgggtcgca tcatggccct gaccgcgcgc aaccccgagg 12000 ccttcaggca gcagcctcag gctaaccggc tggcggccat cttggaagcg gtagtgcccg 12060 cgcgctccaa ccccacccac gagaaggtgc tggccatagt caacgcgctg gcggagagca 12120 gggccatccg ggcagacgag gccggactgg tgtacgatgc gctgctgcag cgggtggcgc 12180 ggtacaacag cggcaacgtg cagaccaacc tggaccgcct ggtgacggac gtgcgcgagg 12240 ccgtggcgca gcgcgagcgc ttgcatcagg acggcaacct gggctcgctg gtggcgctaa 12300 acgccttcct tagcacccag ccggccaacg taccgcgggg gcaggaggac tacaccaact 12360 tcttgagcgc gctgcggctg atggtgaccg aggtccctca gagcgaggtg taccagtcgg 12420 ggcccgacta cttcttccag accagcagac agggcttgca aaccgtgaac ctgagccagg 12480 ctttcaagaa cctgcggggg ctgtggggag tgaaggcgcc caccggcgac cgggctacgg 12540 tgtccagcct gctaaccccc aactcgcgcc tgctgctgct gctgatcgcg cccttcacgg 12600 acagcgggag cgtctcgcgg gagacctatc tgggccacct gctgacgctg taccgcgagg 12660 ccatcgggca ggcgcaggtg gacgagcaca ccttccagga gatcaccagc gtgagccacg 12720 cgctggggca ggaggacacg ggcagcctgc aggcgaccct gaactacctg ctgaccaaca 12780 ggcggcagaa gattcccacg ctgcacagcc tgacccagga ggaggagcgc atcttgcgct 12840 acgtgcagca gagcgtgagc ctgaacctga tgcgcgacgg cgtgacgccc agcgtggcgc 12900 tggacatgac cgcgcgcaac atggaaccgg gcatgtacgc ttcccagcgg ccgttcatca 12960 accgcctgat ggactacttg catcgggcgg cggccgtgaa ccccgagtac ttcaccaatg 13020 ccattctgaa tccccactgg atgccccctc cgggtttcta caacggggac ttcgaggtgc 13080 ctgaggtcaa cgatgggttc ctctgggatg acatggatga cagtgtgttc tcccccaacc 13140 cgctgcgcgc cgcgtctctg cgattgaagg agggctctga cagggaagga ccaaggagtc 13200 tggcctcctc cctggctctg ggggcggtgg gcgccacggg cgcggcggcg cggggcagca 13260 gccccttccc cagcctggcg gactctctga atagcgggcg ggtgagcagg ccccgcttgc 13320 taggcgagga ggagtatctg aacaactccc tgctgcagcc cgtgagggac aaaaacgctc 13380 agcggcagca gtttcccaac aatgggatag agagcctggt ggacaagatg tccagatgga 13440 agacgtatgc gcaggagtac aaggagtggg aggaccgcca gccgcggccc ctgccgcccc 13500 ctagacagcg ctggcagcgg cgcgcgtcca accgccgctg gaggcagggg cccgaggacg 13560 atgatgactc tgcagatgac agcagcgtgt tggacctggg cgggagcggg aacccctttt 13620 cgcacctgcg cccacgcctg ggcaagatgt tttaaaagag aaaaataaaa actcaccaag 13680 gccatggcga cgagcgttgg ttttttgttc ccttccttag tatgcggcgc gcggcgatgt 13740 tcgaggaggg gcctcccccc tcttacgaga gcgcgatggg aatttctcct gcggcgcccc 13800 tgcagcctcc ctacgtgcct cctcggtacc tgcaacctac aggggggaga aatagcatct 13860 gttactctga gctgcagccc ctgtacgata ccaccagact gtacctggtg gacaacaagt 13920 ccgcggacgt ggcctccctg aactaccaga acgaccacag cgattttttg accacggtga 13980 tccaaaacaa cgacttcacc ccaaccgagg ccagtaccca gaccataaac ctggacaaca 14040 ggtcgaactg gggcggcgac ctgaagacta tcctgcacac caatatgccc aacgtgaacg 14100 agttcatgtt caccaactct tttaaggcgc gggtgatggt ggcgcgcgag cagggggagg 14160 cgaagtacga gtgggtggac ttcacgctgc ccgagggcaa ctactcagag accatgactc 14220 tcgacctgat gaacaatgcg atcgtggaac actatctgaa agtgggcagg cagaacgggg 14280 tgaaggagag cgatatcggg gtcaagtttg acaccagaaa cttccgtctg ggctgggacc 14340 ctgtgaccgg gctggtcatg ccgggggtct acaccaacga ggcctttcat cccgatatag 14400 tgctcctgcc cggctgtggg gtggacttca cccagagccg gctgagcaac ctgctgggcg 14460 ttcgcaagcg gcaacctttc caggagggtt tcaagatcac ctatgaggat ctggaggggg 14520 gcaacattcc cgcgctcctt gatctggacg cctacgagga gagcttgaaa cccgaggaga 14580 gcgctggcga cagcggcgag agtggcgagg agcaagccgg cggcggcggc agcgcgtcgg 14640 tagaaaacga aagtactccc gcagtggcgg cggacgctgc ggaggtcgag ccggaggcca 14700 tgcagcagga cgcagaggag ggcgcgcagg aggacatgaa caatggggag atcaggggcg 14760 acactttcgc cacccggggc gaagaaaaag aggcagaggc ggcggcggcg acggcggaag 14820 ccgaaaccga ggcagaggca gagcccgaga ccgaagttat ggaagacatg aatgatggag 14880 aacgtagggg tgacacgttt gccacccggg gcgaagagaa ggcggcggag gcagaagccg 14940 cggctgagga ggcggctgcg gctgcggcca aggctgaggc tgcggctgag gctaaggtcg 15000 aagccgatgt tgcggttgag gctcaggctg aggaggaggc ggcggctgaa gcagttaagg 15060 aaaaggccca ggcagagcag gaagagaaaa aacctgtcat tcaacctcta aaagaagata 15120 gcaaaaagcg cagttacaac gtcattgagg gcagcacctt tacccaatac cgcagctggt 15180 acctggctta caactacggc gacccggtca agggggtgcg ctcgtggacc ctgctctgca 15240 cgccggacgt cacctgcggc tccgagcaga tgtactggtc gctgccaaac atgatgcaag 15300 acccggtgac cttccgttcc acgcggcagg ttagcaactt tccggtggtg ggcgccgaac 15360 tgctgccagt acactccaag agtttttaca acgagcaggc cgtctactcc cagctgatcc 15420 gccaggccac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15480 gcccgccggc ccccaccatc accaccgtca gtgaaaacgt tcctgccctc acagatcacg 15540 ggacgctacc gctgcgcaac agcatctcag gagtccagcg agtgaccatt actgacgcca 15600 gacgccggac ctgcccctac gtttacaagg ccttgggcat agtctcgccg cgcgtcctct 15660 ccagtcgcac tttttaaaac acatccaccc acacgctcca aaatcatgtc cgtactcatc 15720 tcgcccagca acaacaccgg ctgggggctg cgcgcaccca gcaagatgtt tggaggggca 15780 aggaagcgct ccgaccagca ccccgtgcgc gtgcgcggcc actaccgcgc gccctggggt 15840 gcgcacaagc gcgggcgcac agggcgcacc actgtggatg atgtcattga ctccgtagtg 15900 gagcaggcgc gccactacac acccggcgcg ccgaccgcct ccgccgtgtc caccgtggac 15960 caggcgatcg aaagcgtggt acagggggcg cggcactatg ccaaccttaa aagtcgccgc 16020 cgccgcgtgg cgcgccgcca tcgccggaga ccccgggcta ctgccgccgc gcgccttacc 16080 aaggctctgc tcaagcgcgc caggcgaact ggccaccggg ccgccatgag ggccgcacgg 16140 cgggctgccg ctgccgcgag cgccgtggcc ccgcgggcac gaaggcgcgc ggccgctgcc 16200 gccgccgccg ccatttccag cttggcctcg acgcggcgcg gtaacatata ctgggtgcgc 16260 gactcggtga gcggcacacg tgtgcccgtg cgctttcgcc ccccacggaa ttagcacaag 16320 acaacataca cactgagtct cctgctgttg tgtatcccag cggcgaccgt cagcagcggc 16380 gacatgtcca agcgcaaaat taaagaagag atgctccagg tcatcgcgcc ggagatctat 16440 gggcccccga agaaggagga ggaggattac aagccccgca agctaaagcg ggtcaaaaag 16500 aaaaagaaag atgatgacgt tgacgaggcg gtggagtttg tccgccgcat ggcgcccagg 16560 cgccctgtgc agtggaaggg tcggcgcgtg cagcgagtcc tgcgccccgg caccgcggtg 16620 gtctttacgc ccggcgagcg ttccacgcgc actttcaagc gggtgtacga tgaggtgtac 16680 ggcgacgagg atctgttgga gcaggccaac catcgatttg gggagtttgc atatgggaaa 16740 cggcctcgcg agagtctaaa agaggacctg ctggcgctac cgctggacga gggcaatccc 16800 accccgagtc tgaagccggt gaccctgcaa caggtgctgc ctttgagcgc gcccagcgag 16860 cagaagcgag ggttaaagcg cgagggcggg gacctggcac ccaccgtgca gttgatggtg 16920 cccaagcggc agaagctgga ggacgtgctg gagaaaatga aagtagagcc cgggatccag 16980 cccgagatca aggtccgccc tatcaagcag gtggcgcccg gcgtgggagt ccagaccgtg 17040 gacgttagga ttcccacgga ggagatggaa acccaaaccg ccactccctc ttcggcagca 17100 agcgccacca ccggcgccgc ttcggtagag gtgcagacgg acccctggct acccgccgcc 17160 actatcgccg tcgccgccgc cccccgttcg cgcggacgca agagaaatta tccagcggcc 17220 agcgcgctta tgccccagta tgcgctgcat ccatccatcg cgcccacccc cggctaccgc 17280 gggtactcgt accgcccgcg cagatcagcc ggcactcgcg gccgccgccg ccgtgcgacc 17340 acaaccagcc gccgccgtcg ccgccgccgc cagccagtgc tgacccccgt gtctgtaagg 17400 aaggtggctc gctcggggag cacgctggtg gtgcccagag cgcgctacca ccccagcatc 17460 gtttaaagcc ggtctctgta tggttcttgc agatatggcc ctcacttgtc gccttcgctt 17520 cccggtgccg ggataccgag gaagaactca ccgccgcagg ggcatggcgg gcagcggtct 17580 ccgcggcggc cgtcgccatc gccggcgcgc aaagagcagg cgcatgcgcg gcggtgtgtt 17640 gcccctgctg gtcccgctac tcgccgcggc gatcggcgcc gtgcccggga tcgcctccgt 17700 ggccctgcag gcgtcccaga aacattgact cttgcaacct tgcaagcttg catttttgga 17760 ggaaaaaata aaaaagtcta gactctcacg ctcgcttggt cctgtgacta ttttgtagaa 17820 aaaagatgga agacatcaac tttgcgtcgc tggccccgcg tcacggctcg cgcccgttca 17880 tgggagactg gacagatatc ggcaccagca atatgagcgg tggcgccttc agctggggca 17940 gtctgtggag cggccttaaa aattttggtt ccaccattaa gaactatggc aacaaagcgt 18000 ggaacagcag cacgggtcag atgctgagag acaagttgaa agagcagaac ttccaggaga 18060 aggtggcgca gggcctggcc tctggcatca gcggggtggt ggacatagct aaccaggccg 18120 tgcagaaaaa gataaacagt catctggacc cccgccctca ggtggaggaa acgcctccag 18180 ccatggagac ggtgtctccc gagggcaaag gcgaaaagcg cccgcggccc gacagggaag 18240 agaccctggt gtcacacacc gaggagccgc cctcttacga ggaggcagtc aaggccggcc 18300 tgcccaccac tcgccccata gctcccatgg ccaccggtgt ggtgggtcac aggcaacaca 18360 cccccgcaac actagatctg cccccgccgt ccgagccgac tcgccagcca aaggcggtga 18420 cggtgtccgc tccctccact tccgccgcca acagagtgcc tctgcgccgc gctgcgagcg 18480 gcccccgggc ctcgcgagtc agcggcaact ggcagagcac actgaacagc atcgtgggcc 18540 tgggagtgag gagtgtgaag cgccgccgtt gctactgaat gagcaagcta gctaacgtgt 18600 tgtatgtgtg tatgcgtcct atgtcgccgc cagaggagct gttgagccgc cggcgccgtc 18660 tgcactccag cgaatttcaa gatggcgacc ccatcgatga tgcctcagtg gtcgtacatg 18720 cacatctcgg gccaggacgc ttcggagtac ctgagccccg ggctggtgca gttcgcccgc 18780 gccacagaca cctacttcaa catgagtaac aagttcagga accccactgt ggcgcccacc 18840 cacgatgtga ccacggaccg gtcgcagcgc ctgacgctgc ggttcatccc cgtggatcgg 18900 gaggacaccg cttactctta caaggcgcgg ttcacgctgg ccgtgggcga caaccgcgtg 18960 ctggacatgg cctccactta ctttgacatc cggggggtgc tggacagggg ccccactttt 19020 aagccctact cgggcactgc ctacaacccc ctggccccca agggcgcccc caattcttgt 19080 gagtgggaac aagaggaaaa tcaggtggtc gctgcagatg atgaacttga agatgaagaa 19140 gcgcaagcac aagaggaagc ccctgtgaaa aaaattcatg tatatgctca ggcgcctctt 19200 tctggcgaaa agattaccaa ggatggtttg caaataggta ctgaagtcgt aggagataca 19260 tctaaggaca cttttgcaga taaaacattc caacccgaac ctcagatagg cgagtctcag 19320 tggaacgagg ctgatgccac agtagcagga ggtagagttt tgaaaaagac tacccctatg 19380 agaccttgct atggatccta tgccaggcct accaatgcca acgggggtca aggaattatg 19440 gttgccaatg aacaaggagt gttggagtct aaagtagaaa tgcaattttt ctctaacacc 19500 acaaccctta atgcgcggga tggaaccggc aatcccgaac caaaggtggt gttgtacagc 19560 gaagatgtcc acttggaatc tcccgatact catctgtctt acaagcccaa aaaggatgat 19620 gttaatgcca aaatcatgtt gggtcagcaa gccatgccca acagacccaa cctcattgga 19680 tttagagata atttcattgg gcttatgttt tacaacagca ccggtaacat gggagtgctg 19740 gcgggtcagg cctctcagtt gaatgctgtg gtggacttgc aggatagaaa cacagaactg 19800 tcatatcagc ttatgcttga ttcaattggg gatagaacca gatacttctc catgtggaac 19860 caggcagtgg atagctatga tccagatgtc agaattattg aaaaccatgg gactgaggat 19920 gaactgccca actactgctt ccctttgggc ggcataggag ttactgatac ttatcaaggg 19980 ataaaaaata ccaatggcaa tggtcagtgg accaaagatg atcagttcgc ggaccgcaac 20040 gaaatagggg tgggaaacaa cttcgccatg gagatcaaca tccaggccaa cctttggaga 20100 aacttcctct atgcaaacgt ggggctctac ctgccagaca agctcaagta caaccccacc 20160 aacgtggaca tctctgacaa ccccaacacc tatgactaca tgaacaagcg ggtggtggcc 20220 cctggcctgg tggactgctt tgtcaatgtg ggagccaggt ggtccctgga ctacatggac 20280 aacgtcaacc ccttcaacca ccaccgcaat gcgggtctgc gctaccgctc catgatcctg 20340 ggcaacgggc gctatgtgcc ctttcacatc caggtacccc agaagttctt tgccatcaag 20400 aacctcctgc tcctgcccgg ctcctacacc tacgagtgga acttcaggaa ggatgtgaac 20460 atggtcctac agagctctct gggcaatgac cttagggtgg atggggccag catcaagttt 20520 gacagcatca ccctctatgc tacatttttc cccatggccc acaacaccgc ctccacgctt 20580 gaggccatgc tgagaaacga caccaacgac cagtccttta atgactacct ctctggggcc 20640 aacatgctct acccaatccc agccaaggcc accaacgtgc ccatctccat cccctctcgc 20700 aactgggccg cctttagagg ctgggccttt acccgcctta agaccaagga gaccccctcc 20760 ctgggctcgg gttttgatcc ctactttgtt tactcgggat ccatccccta cctggatggc 20820 accttctacc tcaaccacac tttcaagaag atatccatca tgtatgactc ctccgtcagc 20880 tggccgggca acgaccgctt gctcaccccc aatgagttcg aggtcaagcg cgccgtggac 20940 ggcgagggct acaacgtggc ccagtgcaac atgaccaagg actggttcct ggtgcagatg 21000 ctggccaact acaacatagg ctaccagggc ttttacatcc cagagagcta caaggacagg 21060 atgtactcct tcttcagaaa tttccaaccc atgagccgac aggtggtgga cgagaccaat 21120 tacaaggact atcaagccat tggcatcacc caccagcaca acaactcggg tttcgtgggc 21180 tacctggcgc ccaccatgcg cgagggtcag gcctaccccg ccaacttccc ctaccccttg 21240 ataggcaaga ccgcggtcga cagcgtcacc cagaaaaagt tcctctgcga ccgcaccctc 21300 tggcgcatcc ccttctctag caacttcatg tccatgggtg cgctcacgga cctgggccaa 21360 aacctgcttt atgccaactc tgcccatgcg ctggacatga cttttgaggt ggaccccatg 21420 gacgagccca cccttctcta tattgtgttt gaagtgttcg acgtggtcag agtgcaccag 21480 ccgcaccgcg gtgtcatcga gaccgtgtac ctgcgtacgc ccttctcagc cggcaacgcc 21540 accacctaag gagacagcgc cgccgccgcc tgcatgacgg gttccaccga gcaagagctc 21600 agggccattg ccagagacct gggatgcgga ccctattttt tgggcaccta tgacaaacgc 21660 ttcccgggct ttatctcccg agacaagctc gcctgcgcca ttgtcaacac ggccgcgcgc 21720 gagaccgggg gcgtgcactg gctggccttt ggctgggacc cgcgctccaa aacttgctac 21780 ctctttgacc cctttggctt ctccgatcag cgcctcaggc agatttatga gtttgagtac 21840 gaggggctgc tgcgccgcag cgcgctcgcc tcctcgcccg accgctgcat cacccttgag 21900 aagtccaccg aaaccgtgca ggggccccac tcggccgcct gcggtctctt ctgttgcatg 21960 tttttgcacg cctttgtgca ctggcctcag agtcccatgg attgcaaccc caccatgaac 22020 ttgctaaagg gagtgcccaa cgccatgctc cagagccccc aggtccagcc caccctgcgc 22080 cgcaaccagg aacagcttta ccgcttcctg gagcgccact ccccctactt ccgcagccac 22140 agcgcgcgca tccggggggc cacctctttt tgccacttgc aagaaaacat gcaagacgga 22200 aaatgatgta cagcatgctt ttaataaatg taaagactgt gcactttaat tatacacggg 22260 ctctttctgg ttatttattc aacaccgccg tcgccattta gaaatcgaaa gggttctgcc 22320 gtgcgtcgcc gtgcgccacg ggcagagaca cgttgcgata ctggaagcgg ctcgcccact 22380 tgaactcggg caccaccatg cggggcagtg gttcctcggg gaagttctcg ctccacaggg 22440 tgcgggtcag ctgcagcgcg ctcaggaggt cgggagccga gatcttgaag tcgcagttgg 22500 ggccggaacc ctgcgcgcgc gagttgcggt acacggggtt gcagcactgg aacaccagca 22560 gggccggatt attcacgctg gccagcaggc tctcgtcgct gatcatgtcg ctgtccagat 22620 cctccgcgtt gctcagggcg aatggggtca tcttgcagac ctgcctgccc aggaaaggcg 22680 ggagcccagg cttgccgttg cagtcgcagc gcaggggcat tagcaggtgc ccacggcccg 22740 actgcgcctg cgggtacaac gcgcgcatga aggcttcgat ctgcctaaaa gccacctggg 22800 tcttggctcc ctccgaaaag aacatcccac aggacttgct ggagaactgg ttcgcgggac 22860 agctggcatc gtgcaggcag cagcgcgcgt cagtgttggc aatctgcacc acgttgcgac 22920 cccaccggtt tttcactatc ttggccttgg aagcctgctc ctttagcgcg cgctggccgt 22980 tctcgctggt cacatccatc tctatcacct gttccttgtt gatcatgttt gtcccgtgca 23040 gacactttag gtcgccctcc gtctgggtgc agcggtgctc ccacagcgcg caaccggtgg 23100 gctcccaatt cttgtgggtc acccccgcgt aggcctgcag gtaggcctgc aggaagcgcc 23160 ccatcatggt cataaaggtc ttctggctcg taaaggtcag ctgcaggccg cgatgctctt 23220 cgttcagcca ggtcttgcag atggcggcca gcgcctcggt ctgctcgggc agcatcttaa 23280 aatttgtctt caggtcgtta tccacgtggt acttgtccat catggcacgc gccgcctcca 23340 tgcccttctc ccaggcggac accatgggca ggcttagggg gtttatcact tccagcggcg 23400 aggacaccgt actttcgatt tcttcttcct ccccctcttc ccggcgcgcg cccccgctgt 23460 tgcgcgctct taccgcctgc accaaggggt cgtcttcagg caagcgccgc accgagcgct 23520 tgccgccctt gacctgcttg atcagtaccg gcgggttgct gaagcccacc atggtcagcg 23580 ccgcctgctc ttcttcgtct tcgctgtcta ccactatttc tggggagggg cttctccgct 23640 ctgcggcaaa ggcggcggat cgcttctttt ttttcttggg agccgccgcg atggagtccg 23700 ccacggcgac cgaggtcgag ggcgtggggc tgggggtgcg cggtaccagg gcctcgtcgc 23760 cctcggactc ttcctctgac tccaggcggc ggcggagtcg cttctttggg ggcgcgcgcg 23820 tcagcggcgg cggagacggg gacggggacg gggacgggac gccctccaca gggggtggtc 23880 ttcgcgcaga cccgcggccg cgctcggggg tcttctcgcg ctggtcttgg tcccgactgg 23940 ccattgtatc ctcctcctcc taggcagaga gacataagga gtctatcatg caagtcgaga 24000 aggaggagag cttaaccacc ccctcagaga ccgccgatgc gcccgccgtc gccgtcgccc 24060 ccgctaccgc cgacgcgccc gccacaccga gcgacacccc cacggacccc cccgccgacg 24120 cacccctgtt cgaggaagcg gccgtggagc aggacccggg ctttgtctcg gcagaggagg 24180 atttgcaaga ggaggagaat aaggaggaga agccctcagt gccaaaagat cataaagagc 24240 aagacgagca cgacgcagac gcacaccagg gtgaagtcgg gcggggggac ggagggcatg 24300 gcggcgccga ctacctagac gaaggaaacg acgtgctctt gaagcacctg catcgtcagt 24360 gcgccatcgt ctgcgacgct ctgcaggagc gcagcgaggt gcccctcagc gtggcggagg 24420 tcagccgcgc ctacgagctc agcctctttt ccccccgggt gcccccccgc cgccgcgaaa 24480 acggcacatg cgagcccaac ccgcgcctca acttctaccc cgcctttgtg gtgcccgagg 24540 tcctggccac ctatcacatc ttctttcaaa attgcaagat ccccatctcg tgccgcgcca 24600 accgtagccg cgccgataag atgctggccc tgcgccaggg cgaccacata cctgatatcg 24660 ccgctttgga agatgtgcca aagatcttcg agggtctggg gcgcaacgag aagcgggcag 24720 caaactctct gcaacaggaa aacagcgaaa atgagagtca cactggagcg ctggtggagc 24780 tggagggcga caacgcccgc ctggcggtgc tcaagcgcag catcgaggtc acccactttg 24840 cctaccccgc gctcaacctg ccccccaaag tcatgaacgc ggtcatggac gggctgatca 24900 tgcgccgcgg ccggcccctc gctccagatg caaacttgca tgaggagacc gaggacggtc 24960 agcccgtggt cagcgacgag cagctgacgc gctggctgga gagcgcggac cccgccgaac 25020 tggaggagcg gcgcaagatg atgatggccg cggtgctggt caccgtagag ctggagtgtc 25080 tgcagcgctt cttcggtgac cccgagatgc agagaaaggt cgaggagacc ctacactaca 25140 ccttccgcca gggctacgtg cgccaggctt gcaagatctc caacgtggag ctcagcaacc 25200 tggtgtccta cctgggcatc ttgcatgaaa accgccttgg gcagagcgtg ctacactcca 25260 ccctgcgcgg ggaggcgcgc cgcgactacg tgcgcgactg cgtttacctc ttcctctgct 25320 acacctggca gacggccatg ggggtctggc agcagtgcct ggaggagcgc aacctcaagg 25380 agctggagaa gcttctgcag cgcgcgctca aagacctctg gacgggcttc aacgagcgct 25440 cggtggccgc cgcgctagcc gacctcatct tccccgagcg cctgctcaaa accctccagc 25500 aggggctgcc cgacttcacc agccaaagca tgttgcaaaa ttttaggaac tttatcctgg 25560 agcgttctgg catcctaccc gccacctgct gcgccctgcc cagcgacttt gtccccctcg 25620 tgtaccgcga gtgccccccg ccgctgtggg gccactgcta cctgttccaa ctggccaact 25680 acctgtccta ccacgcggac ctcatggagg actccagcgg cgaggggctc atggagtgcc 25740 actgccgctg caacctctgc acgccccacc gctccctggt ctgcaacacc caactgctca 25800 gcgagagtca gattatcggt accttcgagc tacagggtcc gtcctcctca gacgagaagt 25860 ccgcggctcc ggggctaaaa ctcactccgg ggctgtggac ttccgcctac ctgcgcaaat 25920 ttgtacctga agactaccac gcccacgaaa tcaggtttta cgaggaccaa tcccgcccgc 25980 ccaaggcgga gctgaccgcc tgcgtcatca cccagggcga gatcctaggc caattgcaag 26040 ccatccaaaa agcccgccaa gagtttttgc tgaagagggg tcggggggtg tatctggacc 26100 cccagtcggg tgaggagctc aacccggttc ccccgctgcc accgccgcgg gaccttgctt 26160 cccaggataa gcatcgccat ggctcccaga aagaagcagc agcggccgcc gctgccgccg 26220 ccccacatgc tggaggaaga ggaggaatac tgggacagtc aggcagagga ggtttcggac 26280 gaggaggagc cggagacgga gatggaagag tgggaggagg acagcttaga cgaggaggct 26340 tccgaagccg aagaggcagg cgcaacaccg tcaccctcgg ccgcagcccc ctcgcaggcg 26400 cccccgaagt ccgctcccag catcagcagc aacagcagcg ctataacctc cgctcctcca 26460 ccgccgcgac ccacggccga ccgcagaccc aaccgtagat gggacaccac cggaaccggg 26520 gccggtaagt cctccgggag aggcaagcaa gcgcagcgcc aaggctaccg ctcgtggcgc 26580 gctcacaaga acgccatagt cgcttgcttg caagactgcg gggggaacat ctccttcgcc 26640 cgccgcttcc tgctcttcca ccacggtgtg gccttccccc gtaacgtcct gcattactac 26700 cgtcatctct acagccccta ctgcggcggc agtgagccag aggcggccag cggcggcggc 26760 gcccgtttcg gtgcctagga agacccaggg caagacttca gccaagaaac tcgcggcgac 26820 cgcggcgaac gcggtcgcgg gggccctgcg cctgacggtg aacgaacccc tgtcgacccg 26880 cgaactgagg aaccgaatct tccccactct ctatgccatc ttccagcaga gcagagggca 26940 ggatcaggaa ctgaaagtaa aaaacaggtc tctgcgctcc ctcacccgca gctgtctgta 27000 tcacaagagc gaagaccagc ttcggcgcac gctggaggac gctgaggcac tcttcagcaa 27060 atactgcgcg ctcactctta aggactagct ccgcgccctt ctcgaattta ggcgggaacg 27120 cctacgtcat cgcagcgccg ccgtcatgag caaggacatt cccacgccat acatgtggag 27180 ctatcagccg cagatgggac tcgcggcggg cgcctcccaa gactactcca cccgcatgaa 27240 ctggctcagt gccggcccac acatgatctc acaggttaat gacatccgca cccatcgaaa 27300 ccaaatattg gtgaagcagg cggcaattac caccacgccc cgcaataatc ccaaccccag 27360 ggagtggccc gcgtccctgg tgtatcagga aattcccggc cccaccaccg tactacttcc 27420 gcgtgattcc caggccgaag tccaaatgac taactcaggg gcacagctcg cgggcggctg 27480 tcgtcacagg gtgcggcctc ctcgccaggg tataactcac ctggagatcc gaggcagagg 27540 tattcagctc aacgacgagt cggtgagctc ctcgctcggt ctcagacctg acgggacctt 27600 ccagatagcc ggagccggcc gatcttcctt cacgccccgc caggcgtacc tgactctgca 27660 gagctcgtcc tcggcgccgc gctcgggcgg catcgggact ctccagttcg tgcaggagtt 27720 tgtgccctcg gtctacttca accccttctc gggctctccc ggtcgctacc cggaccagtt 27780 tatcccgaac tttgacgccg cgagggactc ggtggacggc tacgactgaa tgtcgggtgg 27840 acccggtgca gagcaacttc gcctgaagca ccttgaccac tgccgccgcc ctcagtgctt 27900 tgcccgctgt cagaccggtg agttccagta cttttccctg cccgactcgc acccggacgg 27960 cccggcgcac ggggtgcgct ttttcatccc gagtcaggtc cgctctaccc taatcaggga 28020 gttcaccgcc cgtcccctac tggcggagtt ggaaaagggg ccttctatcc taaccattgc 28080 ctgcatttgc tctaaccctg gattacacca agatctttgc tgtcatttgt gtgctgagta 28140 taataaaggc tgagatcaga atctactcgg accttatccc tttcaattga tcataactgt 28200 aatcaataaa aaatcactta cttgaaatct gatagcaaga ctctgtccaa ttttttcagc 28260 aacacttcct tcccctcctc ccaactctgg tactctaggc gcctcctagc tgcaaacttc 28320 ctccacagtc tgaagggaat gtcagattcc tcctcctgtc cctccgcacc cacgatcttc 28380 atgttgttac agatgaaacg cgcgagatcg tctgacgaga ccttcaaccc cgtgtacccc 28440 tacgataccg agatcgctcc gacttctgtc cctttcctta cccctccctt tgtatcatcc 28500 gcaggaatgc aagaaaatcc agctggggtg ctgtccctgc acctgtcaga gccccttacc 28560 acccacaatg gggccctgac tctaaaaatg gggggcggcc tgaccctgga caaggaaggg 28620 aatctcactt cccaaaacat caccagtgtc gatccccctc tcaaaaaaag caagaacaac 28680 atcagccttc agaccgccgc acccctcgcc gtcagctccg gggccctaac cctttttgcc 28740 actccccccc tagcggtcag tggcgacaac cttactgtgc agtctcaggc ccctcttact 28800 ttggaagact caaaactaac tctggccacc aaaggacccc taactgtgtc cgaaggcaaa 28860 cttgtcctag aaacagagcc tcccctgcat gcaagtgaca gcagtagcct gggccttagc 28920 gtcacggccc cacttagcat taacaatgac agcctaggac tagacatgca agcgcccatc 28980 agctctcgag atggaaaact ggctctaaca gtggcggccc ccctaactgt ggccgagggt 29040 atcaatgctt tggcagtagc cacaggtaat ggtattggac taaatgaaac caacacacac 29100 ctgcaggcaa aactggtcgc gcccctaggc tttgatacca acggcaacat taagctaagc 29160 gtcgcaggag gcatgaggct aaacaataac acactgatac tagatgtaaa ctacccattt 29220 gaggctcaag gccaactgag cctaagagtg ggctcgggcc cactatatgt agattctagt 29280 agtcataacc taaccattag atgccttagg ggattgtatg taacatcttc taacaaccaa 29340 aacggtctag aggccaacat taaactaaca aaaggccttg tgtatgacgg aaatgccata 29400 gcagttaatg ttggcaaagg gctggaatac agccctactg gcacaacaga aaaacctata 29460 cagactaaaa taggtctagg catggagtat gacactgagg gagccatgat gacaaaacta 29520 ggctctggac taagctttga caattcagga gccattgtgg tgggaaacaa aaatgatgac 29580 aggcttactt tgtggaccac accggaccca tcgcccaact gtcagattta ctctgaaaaa 29640 gatgctaaac taaccttggt actgactaaa tgtggcagtc aggttgtagg cacagtatct 29700 attgccgctc ttaaaggtag ccttgtgcca atcactagtg caatcagtgt ggttcagata 29760 tacctaaggt ttgatgaaaa tggggtgctg atgagtaact cttcacttaa tggcgaatac 29820 tggaatttta gaaacggaga ctcaactaat ggcacaccat atacaaacgc agtgggtttt 29880 atgcctaatc tactggccta tcctaaaggt caaactacaa ctgcaaaaag taacattgtc 29940 agccaggtct acatgaacgg ggacgatact aaacccatga catttacaat caacttcaat 30000 ggccttagtg aaacagggga tacccctgtc agtaaatatt ccatgacatt ctcatggagg 30060 tggccaaatg gaagctacat agggcacaat tttgtaacaa actcctttac tttctcctac 30120 atcgcccaag aataaagaaa gcacagagat gcttgttttt gatttcaaaa ttgtgtgctt 30180 ttatttattt tcaagcttac agtatttcca gtagtcatta gaatagagct taattaaact 30240 gcatgagaac ccttccacat agcttaaatt atcaccagtg caaatggaaa aaaatcaaca 30300 taccttttta tccagatatc aaagaactct agtggtcagt tttcccccac cctcccagct 30360 cacagaatac acagtccttt ccccccggct ggctttaaac aacactatct cattggtaac 30420 agacatattt ttaggtgtaa taatccacac ggtctcttgg cgggccaaac gctggtctgt 30480 gatgttaata aactccccag gcagctcttt caagttcacg tcgctgtcca actgctgaag 30540 cgctcgcggc tccgactgcg cctctagcgg aggcaacggc agcacccgat ccttgatcta 30600 taaaggagta gagtcataat cccccataag aatagggcgg tgatgcagca acaaggcgcg 30660 cagcaactcc tgccgccgcc tctccgtacg acaggaatgc aacggggtgg tggtctcctc 30720 cgcgataatc cgcaccgctc gcagcatcag catcctcgtc ctccgggcac agcagcgcat 30780 cctgatctca ctgagatcgg cgcagtaagt gcagcacaac accaagatgt tatttaagat 30840 cccacagtgc aaagcactgt acccaaagct catggcggga aggacagccc ccacgtgacc 30900 atcgtaccag atcctcaggt aaatcaaatg acgacctctc ataaacacgc tggacatata 30960 catcacctcc ttgggcatga gctgattcac cacctctcga taccacaggc atcgctgatt 31020 aattaaagac ccctcgagca ccatcctgaa ccaggaagcc agcacctgac cccccgccag 31080 gcactgcagg gaccccggtg aatcgcagtg gcagtgaaga ctccagcgct cgtagccgtg 31140 aaccatagag ctggtcatta tatccacatt ggcacaacac agacacactt tcatacactt 31200 tttcatgatt agcagctcct ctctagtcaa gaccatatcc caaggaatca cccactcttg 31260 aatcaaggta aatcccacac agcagggcag gcctctcaca taactcacgt tatgcatagt 31320 gagcgtgtcg caatctggaa ataccggatg atcttccatc accgaagccc gggtctccgt 31380 ctcaaaggga ggtaaacggt ccctcgtgta gggacagtgg cgggataatc gagatcgtgt 31440 tgaacgtaga gtcatgccaa agggaacagc ggacgtactc atatttcctc cagcagaacc 31500 aagtgcgcgc gtggcagcta tccctgcgtc ttctgtctcg ccgcctgccc cgctcggtgt 31560 agtagttgta atacagccac tccctcagac cgtcaaggcg ctccctggcg tccggatcta 31620 taacaacacc gtcctgcagc gccgccctga tgacatccac caccgtagag tatgccaagc 31680 ccagccacga aatgcactca ctttgacagc gagagatagg aggagcggga agagatggaa 31740 gaaccatgat agtaaaagaa cttttattcc aatcgatcct ctacaatgtc aaagtgtaga 31800 tctatcagat ggcactggtc tcctccgctg agtcgatcaa aaataacagc taaaccacaa 31860 acaacacgat tggtcaaatg ctgcacaagg gcttgcagca taaaatcgcc tcgaaagtcc 31920 accgcaagca taacatcaaa gccaccgccc ctatcatgat ctatgataaa aaccccacag 31980 ctatccacca gacccatata gttttcatct ctccatcgtg aaaaaatatt tacaagctcc 32040 tcctttaaat cacctccaac caattcaaaa agttgagcca gaccgccctc caccttcatt 32100 ttcagcatgc gcatcatgat tgcaaaaatt caggctcctc agacacctgt ataagattga 32160 gaagcggaac gttaacatca atgtttcgct cgcgaagatc gcgcctcagt gcaagcatga 32220 tataatccca caggtcggag cggatcagcg aggacatctc cccgccagga accaactcaa 32280 cggagcctat gctgattata atacgcatat tcggggctat gctaaccagc acggccccca 32340 aataggcgta ctgcataggc ggcgacaaaa agtgaacagt ttgggttaaa aaatcaggca 32400 aacactcgcg caaaaaagca agaacatcat aaccatgctc atgcaaatag atgcaagtaa 32460 gctcaggaac gaccacagaa aaatgcacaa tttttctctc aaacatgact gcgagccctg 32520 caaaaaataa aaaagaaaca ttacacaaga gtagcctgtc ttacaatggg atagactact 32580 ctaaccaaca taagacgggc cacgacatcg cccgcgtggc cataaaaaaa attatccgtg 32640 tgattaaaaa gaagcacaga tagctggcca gtcatatccg gagtcatcac gtgcgaaccc 32700 gtgtagaccc ccgggttgga cacatcggcc aaacaaagaa agcggccaat gtatcccgga 32760 ggaatgataa cactaagacg aagatacaac agaataaccc catggggggg aataacaaag 32820 ttagtaggtg aataaaaacg ataaacaccc gaaactccct cctgcgtagg caaaatagcg 32880 ccctcccctt ccaaaacaac atacagcgct tccacagcag ccatgacaaa agactcaaaa 32940 cactcaaaag actcagtctt accaggaaaa taaaagcact ctcacagcac cagcactaat 33000 cagagtgtga agagggccaa gtgccgaacg agtatatata ggaattaaaa atgacgtaaa 33060 tgtgtaaagg tcaaaaaacg cccagaaaaa tacacagacc aacgcccgaa acgaaaaccc 33120 gcgaaaaaat acccagaagt tcctcaacaa ccgccacttc cgctttccca cgatacgtca 33180 cttcctcaaa aatagcaaac tacatttccc acatgtacaa aaccaaaacc cctccccttg 33240 tcaccgccca caacttacat aatcacaaac gtcaaagcct acgtcacccg ccccgcctcg 33300 ccccgcccac ctcattatca tattggcctc aatccaaaat aaggtatatt attgatgatg 33360 <210> 73 <211> 33360 <212> DNA <213> Artificial Sequence <220> <223> GADNOU20 GAG (DE1DE3) <400> 73 catcatcaat aatatacctt attttggatt gaggccaata tgataatgag gtgggcgggg 60 cgaggcgggg cgggtgacgt aggacgcgcg agtagggttg ggaggtgtgg cggaagtgtg 120 gcatttgcaa gtgggaggag ctgacatgca atcttccgtc gcggaaaatg tgacgttttt 180 gatgagcgcc gcctacctcc ggaagtgcca attttcgcgc gcttttcacc ggatatcgta 240 gtaattttgg gcgggaccat gtaagatttg gccattttcg cgcgaaaagt gaaacgggga 300 agtgaaaact gaataatagg gcgttagtca tagcgcgtaa tatttaccga gggccgaggg 360 actttgaccg attacgtgga ggactcgccc aggtgttttt tacgtgaatt tccgcgttcc 420 gggtcaaagt ctccgttttt attgtcgccg tcatctgacg ggccgccatt gcatacgttg 480 tatccatatc ataatatgta catttatatt ggctcatgtc caacattacc gccatgttga 540 cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca 600 tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac 660 gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact 720 ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa 780 gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg 840 cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta 900 gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg 960 tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg 1020 caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg 1080 ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctctccctat cagtgataga 1140 gatctcccta tcagtgatag agatcgtcga cgagctcgtt tagtgaaccg tcagatcgcc 1200 tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg atccagcctc 1260 cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga gatctaccat 1320 gggtgctagg gcttctgtgc tgtctggtgg tgagctggac aagtgggaga agatcaggct 1380 gaggcctggt ggcaagaaga agtacaagct aaagcacatt gtgtgggcct ccagggagct 1440 ggagaggttt gctgtgaacc ctggcctgct ggagacctct gaggggtgca ggcagatcct 1500 gggccagctc cagccctccc tgcaaacagg ctctgaggag ctgaggtccc tgtacaacac 1560 agtggctacc ctgtactgtg tgcaccagaa gattgatgtg aaggacacca aggaggccct 1620 ggagaagatt gaggaggagc agaacaagtc caagaagaag gcccagcagg ctgctgctgg 1680 cacaggcaac tccagccagg tgtcccagaa ctaccccatt gtgcagaacc tccagggcca 1740 gatggtgcac caggccatct ccccccggac cctgaatgcc tgggtgaagg tggtggagga 1800 gaaggccttc tcccctgagg tgatccccat gttctctgcc ctgtctgagg gtgccacccc 1860 ccaggacctg aacaccatgc tgaacacagt ggggggccat caggctgcca tgcagatgct 1920 gaaggagacc atcaatgagg aggctgctga gtgggacagg ctgcatcctg tgcacgctgg 1980 ccccattgcc cccggccaga tgagggagcc caggggctct gacattgctg gcaccacctc 2040 caccctccag gagcagattg gctggatgac caacaacccc cccatccctg tgggggaaat 2100 ctacaagagg tggatcatcc tgggcctgaa caagattgtg aggatgtact cccccacctc 2160 catcctggac atcaggcagg gccccaagga gcccttcagg gactatgtgg acaggttcta 2220 caagaccctg agggctgagc aggcctccca ggaggtgaag aactggatga cagagaccct 2280 gctggtgcag aatgccaacc ctgactgcaa gaccatcctg aaggccctgg gccctgctgc 2340 caccctggag gagatgatga cagcctgcca gggggtgggg ggccctggtc acaaggccag 2400 ggtgctggct gaggccatgt cccaggtgac caactccgcc accatcatga tgcagagggg 2460 caacttcagg aaccagagga agacagtgaa gtgcttcaac tgtggcaagg tgggccacat 2520 tgccaagaac tgtagggccc ccaggaagaa gggctgctgg aagtgtggca aggagggcca 2580 ccagatgaag gactgcaatg agaggcaggc caacttcctg ggcaaaatct ggccctccca 2640 caagggcagg cctggcaact tcctccagtc caggcctgag cccacagccc ctcccgagga 2700 gtccttcagg tttggggagg agaagaccac ccccagccag aagcaggagc ccattgacaa 2760 ggagctgtac cccctggcct ccctgaggtc cctgtttggc aacgacccct cctcccagta 2820 aaataaagcc catcagaatt cagtcgacag cggccgcgat ctgctgtgcc ttctagttgc 2880 cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc 2940 actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct 3000 attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg 3060 catgctgggg atgcggtggg ctctatggcc gggccgcgat cgcgcttagg cctgaccatc 3120 tggtgctggc ctgcaccagg gccgagtttg ggtctagcga tgaggatacc gattgaggtg 3180 ggtaaggtgg gcgtggctag cagggtgggc gtgtataaat tgggggtcta aggggtctct 3240 ctgtttgtct tgcaacagcc gccgccatga gcgacaccgg caacagcttt gatggaagca 3300 tctttagtcc ctatctgaca gtgcgcatgc ctcactgggc cggagtgcgt cagaatgtga 3360 tgggttccaa cgtggatgga cgtcccgttc tgccttcaaa ttcgtctact atggcctacg 3420 cgaccgtggg aggaactccg ctggacgccg cgacctccgc cgccgcctcc gccgccgccg 3480 cgaccgcgcg cagcatggct acggaccttt acagctcttt ggtggcgagc agcgcggcct 3540 ctcgcgcgtc tgctcgggat gagaaactga ctgctctgct gcttaaactg gaagacttga 3600 cccgggagct gggtcaactg acccagcagg tttccagctt gcgtgagagc agccttgcct 3660 ccccctaatg gcccataata taaataaaag ccagtctgtt tggattaagc aagtgtatgt 3720 tctttattta actctccgcg cgcggtaagc ccgggaccag cggtctcggt cgtttagggt 3780 gcggtggatt ttttccaaca cgtggtacag gtggctctgg atgtttagat acatgggcat 3840 gagtccatcc ctggggtgga ggtagcacca ctgcagagct tcgtgctcgg gggtggtgtt 3900 gtatatgatc cagtcgtagc aggagcgctg ggcgtggtgc tgaaaaatgt ccttaagcaa 3960 gaggcttata gctaggggga ggcccttggt gtaagtgttt acaaatctgc ttagctggga 4020 ggggtgcatc cggggggata tgatgtgcat cttggactgg atttttaggt tggctatgtt 4080 cccgcccaga tcccttctgg gattcatgtt gtgcaggacc accagcacgg tatatccagt 4140 gcacttggga aatttatcgt ggagcttaga cgggaatgca tggaagaact tggagacgcc 4200 cttgtggcct cccagatttt ccatacattc gtccatgatg atggcaatgg gcccgtggga 4260 agctgcctga gcaaaaacgt ttctggcatc gctcacatcg tagttatgtt ccagggtgag 4320 gtcatcatag gacatcttta cgaatcgggg gcgaagggtc ccggactggg ggatgatggt 4380 accctcgggc cccggggcgt agttcccctc acagatctgc atctcccagg ctttcatttc 4440 agagggaggg atcatatcca cctgcggggc gatgaaaaag acagtttctg gcgcagggga 4500 gattaactgg gatgagagca ggtttctgag cagctgtgac tttccacagc cggtgggccc 4560 atatatcacg cctatcaccg gctgcagctg gtagttaaga gagctgcagc tgccgtcctc 4620 ccggagcagg ggggccacct cgttgagcat atccctgacg tggatgttct ccctgaccag 4680 ttccgccaga aggcgctcgc cgcccagcga aagcagctct tgcaaggaag caaaattttt 4740 cagcggtttc aggccatcgg ccgtgggcat gtttttcagc gtctgggtca gcagctccag 4800 cctgtcccag agctcggtga tgtgctctac ggcatctcga tccagcagat ctcctcgttt 4860 cgcgggttgg ggcggctttc gctgtagggc accagccgat gggcgtccag cggggccaga 4920 gtcatgtcct tccatgggcg cagggtcctc gtcagggtgg tctgggtcac ggtgaagggg 4980 tgcgctccgg gttgggcact ggccagggtg cgcttgaggc tggttctgct ggtgctgaat 5040 cgctgccgct cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt ctcgtagtcg 5100 agaccctcgg cggcgtgccc cttggcgcgg agctttccct tggaggtggc gccgcacgag 5160 gggcactgca ggctcttcag ggcgtagagc ttgggagcga gaaacacgga ctctggggag 5220 taggcgtccg cgccgcaggc cgagcagacc gtctcgcatt ccaccagcca agtgagttcc 5280 gggcggtcag ggtcaaaaac caggttgccc ccatgctttt tgatgcgttt cttaccttgg 5340 ctctccatga ggcggtgtcc cttctcggtg acgaagaggc tgtccgtgtc cccgtagacc 5400 gacttcaggg gcctgtcttc cagcggagtg cctctgtcct cctcgtagag aaactctgac 5460 cactctgaga cgaaggcccg cgtccaggcc aggacgaagg aggccacgtg ggaggggtag 5520 cggtcgttgt ccactagcgg gtccaccttc tccagggtgt gcaggcacat gtccccctcc 5580 tccgcgtcca gaaaagtgat tggcttgtag gtgtaggaca cgtgaccggg ggttcccaac 5640 gggggggtat aaaagggggt gggtgccctt tcatcttcac tctcttccgc atcgctgtct 5700 gcgagagcca gctgctgggg taagtattcc ctctcgaagg cgggcatgac ctcagcgctc 5760 aggttgtcag tttctaaaaa tgaggaggat ttgatgttca cctgtccgga ggtgatacct 5820 ttgagggtac ctgggtccat ctggtcagaa aacactattt ttttgttatc aagcttggtg 5880 gcgaatgacc cgtagagggc gttggagagc agcttggcga tggagcgcag ggtctggttt 5940 ttgtcgcggt cggctcgctc cttggccgcg atgttgagtt gcacgtactc gcgggccacg 6000 cacttccact cggggaacac ggtggtgcgc tcgtctggga tcaggcgcac cctccagccg 6060 cggttgtgca gggtgaccat gtcgacgctg gtggcgacct caccgcgcag acgctcgttg 6120 gtccagcaga ggcggccgcc cttgcgcgag cagaaggggg gtagggggtc cagctggtcc 6180 tcgtttgggg ggtccgcgtc gatggtaaag accccgggga gcaggcgcgg gtcaaagtag 6240 tcgatcttgc aagcttgcat gtccagagcc cgctgccatt cgcgggcggc gagcgcgcgc 6300 tcgtaggggt tgaggggcgg gccccagggc atggggtggg tgagcgcgga ggcgtacatg 6360 ccgcagatgt catacacgta caggggttcc ctgaggatac cgaggtaggt ggggtagcag 6420 cgccccccgc ggatgctggc gcgcacgtag tcatagagct cgtgggaggg ggccagcatg 6480 ttgggcccga ggttggtgcg ctgggggcgc tcggcgcgga agacgatctg cctgaagatg 6540 gcgtgggagt tggaggagat ggtgggccgc tggaagacgt tgaagcttgc ttcttgcaag 6600 cccacggagt ccctgacgaa ggaggcgtag gactcgcgca gcttgtgcac cagctcggcg 6660 gtgacctgga cgtcgagcgc acagtagtcg agggtctcgc ggatgatgtc atacctatcc 6720 tcccccttct ttttccacag ctcgcggttg aggacgaact cttcgcggtc tttccagtac 6780 tcttggaggg gaaacccgtc cgtgtccgaa cggtaagagc ctagcatgta gaactggttg 6840 acggcctggt aggggcagca gcccttctcc acgggcagcg cgtaggcctg cgccgccttg 6900 cggagggagg tgtgggtgag ggcgaaagtg tccctgacca tgactttgag gtattgatgt 6960 ctgaagtctg tgtcatcgca gccgccctgt tcccacaggg tgtagtccgt gcgctttttg 7020 gagcgcgggt tgggcaggga gaaggtgagg tcattgaaga ggatcttccc cgctcgaggc 7080 atgaagtttc tggtgatgcg aaagggccct gggaccgagg agcggttgtt gatgacctgg 7140 gcggccagga cgatctcgtc aaagccgttt atgttgtgtc ccacgatgta gagctccagg 7200 aagcggggct ggcccttgat ggaggggagc tttttaagtt cctcgtaggt aagctcctcg 7260 ggcgattcca ggccgtgctc ctccagggcc cagtcttgca agtgagggtt ggccgccagg 7320 aaggatcgcc agaggtcgcg ggccatgagg gtctgcaggc ggtcgcggaa ggttctgaac 7380 tgccgcccca cggccatttt ttcgggggtg atgcagtaga aggtgagggg gtctttctcc 7440 caggggtccc atctgagctc tcgggcgagg tcgcgcgcgg cagcgaccag agcctcgtcg 7500 ccccccagtt tcatgaccag catgaagggc acgagttgct tgccaaaggc tcccatccaa 7560 gtgtaggttt ctacatcgta ggtgacaaag aggcgctccg tgcgaggatg agagccgatt 7620 gggaagaact ggatctcccg ccaccagttg gaggattggc tgttgatgtg gtgaaagtag 7680 aagtcccgtc tgcgggccga gcactcgtgc tggcttttgt aaaagcgacc gcagtactgg 7740 cagcgctgca cgggttgtat atcttgcacg aggtgaacct ggcgacctct gacgaggaag 7800 cgcagcggga atctaagtcc cccgcctggg gtcccgtgtg gctggtggtc ttttactttg 7860 gttgtctggc cgccagcatc tgtctcctgg agggcgatgg tggaacagac caccacgccg 7920 cgagagccgc aggtccagat ctcggcgctc ggcgggcgga gtttgatgac gacatcgcgc 7980 acattggagc tgtccatggt ctccagctcc cgcggcggca ggtcagccgg gagttcctgg 8040 aggttcacct cgcagagacg ggtcaaggcg cggacagtgt tgagatggta tctgatttca 8100 aggggcatgt tggaggcgga gtcgatggct tgcaggaggc cgcagccccg gggggccacg 8160 atggttcccc gcggggcgcg aggggaggcg gaagctgggg gtgtgttcag aagcggtgac 8220 gcgggcgggc ccccggaggt agggggggtt ccggccccac aggcatgggc ggcaggggca 8280 cgtcttcgcc gcgcgcgggc aggggctggt gctggctccg aagagcgctt gcgtgcgcga 8340 cgacgcgacg gttggtgtcc tgtatctggc gcctctgagt gaagaccacg ggtcccgtga 8400 ccttgaacct gaaagagagt tcgacagaat caatctcggc atcgttgaca gcggcctggc 8460 gcaggatctc ctgcacgtcg cccgagttgt cctggtaggc gatttctgcc atgaactgct 8520 cgatctcttc ctcctggaga tctcctcgtc cggcgcgctc cacggtggcc gccaggtcgt 8580 tggagatgcg acccatgagc tgcgagaagg cgttgagtcc gccctcgttc cagacccggc 8640 tgtagaccac gcccccctcg gcgtcgcggg cgcgcatgac cacctgggcc aggttgagct 8700 ccacgtgtcg cgtgaagacg gcgtagttgc gcaggcgctg gaaaaggtag ttcagggtgg 8760 tggcggtgtg ctcggcgacg aagaagtaca tgacccagcg ccgcaacgtg gattcattga 8820 tgtcccccaa ggcctccagg cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa 8880 actgggagtt gcgagcggac acggtcaact cctcctccag aagacggatg agctcggcga 8940 cagtgtcgcg cacctcgcgc tcgaaggcca cggggggcgc ttcttcctct tccacctctt 9000 cttccatgat tgcttcttct tcttcctcag ccgggacggg agggggcggc ggcgggggag 9060 gggcgcggcg gcggcggcgg cgcaccggga ggcggtcgat gaagcgctcg atcatctccc 9120 cccgcatgcg gcgcatggtc tcggtgacgg cgcggccgtt ctcccggggg cgcagctcga 9180 agacgccgcc tctcatttcg ccgcggggcg ggcggccgtg aggtagcgag acggcgctga 9240 ctatgcatct taacaattgc tgtgtaggta cgccgccaag ggacctgatt gagtccagat 9300 ccaccggatc cgaaaacctt tggaggaaag cgtctatcca gtcgcagtcg caaggtaggc 9360 tgagcaccgt ggcgggcggg ggcgggtcgg gagagttcct ggcggagatg ctgctgatga 9420 tgtaattaaa gtaggcggtc ttgagaaggc ggatggtgga caggagcacc atgtctttgg 9480 gtccggcctg ttggatgcgg aggcggtcgg ccatgcccca ggcctcgttc tgacaccggc 9540 gcaggtcttt gtagtaatct tgcatgagtc tttccaccgg cacttcttct ccttcctctt 9600 cttcatctcg ccggtggttt ctcgcgccgc ccatgcgcgt gaccccaaag cccctgagcg 9660 gctgcagcag ggccaggtcg gcgaccacgc gctcggccaa gatggcctgc tgtacctgag 9720 tgagggtcct ctcgaagtca tccatgtcca cgaagcggtg gtaggcaccc gtgttgatgg 9780 tgtaggtgca gttggccatg acggaccagt tgacggtctg gtgtcccggc tgcgagagct 9840 ccgtgtaccg caggcgcgag aaggcgcggg aatcgaacac gtagtcgttg caagtccgca 9900 ccagatactg gtagcccacc aggaagtgcg gcggaggttg gcgatagagg ggccagcgct 9960 gggtggcggg ggcgccgggc gccaggtctt ccagcatgag gcggtggtat ccgtagatgt 10020 acctggacat ccaggtgatg cctgcggcgg tggtggtggc gcgcgcgtag tcgcggaccc 10080 ggttccagat gtttcgcagg ggcgagaagt gttccatggt cggcacgctc tggccggtga 10140 ggcgcgcgca gtcgttgacg ctctatacac acacaaaaac gaaagcgttt acagggcttt 10200 cgttctgtag cctggaggaa agtaaatggg ttgggttgcg gtgtgccccg gttcgagacc 10260 aagctgagct cagccggctg aagccgcagc taacgtggta ttggcagtcc cgtctcgacc 10320 caggccctgt atcctccagg atacggtcga gagccctttt gctttcttgg ccaagcgccc 10380 gtggcgcgat ctgggataga tggtcgcgat gagaggacaa aagcggctcg cttccgtagt 10440 ctggagaaac aatcgccagg gttgcgttgc ggcgtacccc ggttcgagcc cctatggcgg 10500 cttggatcgg ccggaaccgc ggctaacgtg ggctgtggca gccccgtcct caggaccccg 10560 ccagccgact tctccagtta cgggagcgag ccccttttgt ttttttattt tttagatgca 10620 tcccgtgctg cggcagatgc gcccctcgcc ccggcccgat cagcagcagc aacagcaggc 10680 atgcagaccc ccctctcctc tccccgcccc ggtcaccacg gccgcggcgg ccgtgtccgg 10740 tgcggggggc gcgctggagt cagatgagcc accgcggcgg cgacctaggc agtatctgga 10800 cttggaagag ggcgagggac tggcgcggct gggggcgagc tctccagagc gccacccgcg 10860 ggtgcagttg aaaagggacg cgcgtgaggc gtacctgccg cggcaaaacc tgtttcgcga 10920 ccgcgggggc gaggagcccg aggagatgcg ggactgcagg ttccaagcgg ggcgcgagct 10980 gcgccgcggc ttggacagac agcgcctgct gcgcgaggag gactttgagc ccgacacgca 11040 gacgggcatc agccccgcgc gcgcgcacgt ggccgcggcc gacctggtga ccgcctacga 11100 gcagacggtg aaccaggagc gcaacttcca aaaaagcttc aacaaccacg tgcgcacgct 11160 ggtggcgcgc gaggaggtga ccctgggtct catgcatctg tgggacctgg tggaggcgat 11220 cgtgcagaac cccagcagca agcccctgac cgcgcagctg ttcctggtgg tgcagcacag 11280 cagggacaac gaggccttca gggaggcgct gctgaacatc accgagccgg aggggcgctg 11340 gctcctggac ctgataaaca tcctgcagag catagtggtg caggagcgca gcctgagcct 11400 ggccgagaag gtggcggcca ttaactattc tatgctgagc ctgggcaagt tctacgctcg 11460 caagatctac aagaccccct acgtgcccat agacaaggag gtgaagatag acagcttcta 11520 catgcgcatg gcgctgaagg tgctaaccct gagcgacgac ctgggagtgt accgcaacga 11580 gcgcatccac aaggccgtga gcgccagccg gcggcgcgag ctgagcgacc gcgaactgat 11640 gcacagtctg cagcgcgcgc tgaccggcgc gggcgagggc gacagggagg tcgagtccta 11700 ctttgacatg ggggccgacc tgcactggca gccgagccgc cgcgccctgg aagcggcggg 11760 ggcgtacggc ggccccctgg cggccgatga cgaggaagag gaggactatg agctagagga 11820 gggcgagtac ctggaggact gacctggctg gtggtgtttt ggtatagatg caagatccga 11880 acgtggcgga cccggcggtc cgggcggcgc tgcagagcca gccgtccggc attaactcct 11940 ctgacgactg ggccgcggcc atgggtcgca tcatggccct gaccgcgcgc aaccccgagg 12000 ccttcaggca gcagcctcag gctaaccggc tggcggccat cttggaagcg gtagtgcccg 12060 cgcgctccaa ccccacccac gagaaggtgc tggccatagt caacgcgctg gcggagagca 12120 gggccatccg ggcagacgag gccggactgg tgtacgatgc gctgctgcag cgggtggcgc 12180 ggtacaacag cggcaacgtg cagaccaacc tggaccgcct ggtgacggac gtgcgcgagg 12240 ccgtggcgca gcgcgagcgc ttgcatcagg acggcaacct gggctcgctg gtggcgctaa 12300 acgccttcct tagcacccag ccggccaacg taccgcgggg gcaggaggac tacaccaact 12360 tcttgagcgc gctgcggctg atggtgaccg aggtccctca gagcgaggtg taccagtcgg 12420 ggcccgacta cttcttccag accagcagac agggcttgca aaccgtgaac ctgagccagg 12480 ctttcaagaa cctgcggggg ctgtggggag tgaaggcgcc caccggcgac cgggctacgg 12540 tgtccagcct gctaaccccc aactcgcgcc tgctgctgct gctgatcgcg cccttcacgg 12600 acagcgggag cgtctcgcgg gagacctatc tgggccacct gctgacgctg taccgcgagg 12660 ccatcgggca ggcgcaggtg gacgagcaca ccttccagga gatcaccagc gtgagccacg 12720 cgctggggca ggaggacacg ggcagcctgc aggcgaccct gaactacctg ctgaccaaca 12780 ggcggcagaa gattcccacg ctgcacagcc tgacccagga ggaggagcgc atcttgcgct 12840 acgtgcagca gagcgtgagc ctgaacctga tgcgcgacgg cgtgacgccc agcgtggcgc 12900 tggacatgac cgcgcgcaac atggaaccgg gcatgtacgc ttcccagcgg ccgttcatca 12960 accgcctgat ggactacttg catcgggcgg cggccgtgaa ccccgagtac ttcaccaatg 13020 ccattctgaa tccccactgg atgccccctc cgggtttcta caacggggac ttcgaggtgc 13080 ctgaggtcaa cgatgggttc ctctgggatg acatggatga cagtgtgttc tcccccaacc 13140 cgctgcgcgc cgcgtctctg cgattgaagg agggctctga cagggaagga ccaaggagtc 13200 tggcctcctc cctggctctg ggggcggtgg gcgccacggg cgcggcggcg cggggcagca 13260 gccccttccc cagcctggcg gactctctga atagcgggcg ggtgagcagg ccccgcttgc 13320 taggcgagga ggagtatctg aacaactccc tgctgcagcc cgtgagggac aaaaacgctc 13380 agcggcagca gtttcccaac aatgggatag agagcctggt ggacaagatg tccagatgga 13440 agacgtatgc gcaggagtac aaggagtggg aggaccgcca gccgcggccc ctgccgcccc 13500 ctagacagcg ctggcagcgg cgcgcgtcca accgccgctg gaggcagggg cccgaggacg 13560 atgatgactc tgcagatgac agcagcgtgt tggacctggg cgggagcggg aacccctttt 13620 cgcacctgcg cccacgcctg ggcaagatgt tttaaaagag aaaaataaaa actcaccaag 13680 gccatggcga cgagcgttgg ttttttgttc ccttccttag tatgcggcgc gcggcgatgt 13740 tcgaggaggg gcctcccccc tcttacgaga gcgcgatggg aatttctcct gcggcgcccc 13800 tgcagcctcc ctacgtgcct cctcggtacc tgcaacctac aggggggaga aatagcatct 13860 gttactctga gctgcagccc ctgtacgata ccaccagact gtacctggtg gacaacaagt 13920 ccgcggacgt ggcctccctg aactaccaga acgaccacag cgattttttg accacggtga 13980 tccaaaacaa cgacttcacc ccaaccgagg ccagtaccca gaccataaac ctggacaaca 14040 ggtcgaactg gggcggcgac ctgaagacta tcctgcacac caatatgccc aacgtgaacg 14100 agttcatgtt caccaactct tttaaggcgc gggtgatggt ggcgcgcgag cagggggagg 14160 cgaagtacga gtgggtggac ttcacgctgc ccgagggcaa ctactcagag accatgactc 14220 tcgacctgat gaacaatgcg atcgtggaac actatctgaa agtgggcagg cagaacgggg 14280 tgaaggagag cgatatcggg gtcaagtttg acaccagaaa cttccgtctg ggctgggacc 14340 ctgtgaccgg gctggtcatg ccgggggtct acaccaacga ggcctttcat cccgatatag 14400 tgctcctgcc cggctgtggg gtggacttca cccagagccg gctgagcaac ctgctgggcg 14460 ttcgcaagcg gcaacctttc caggagggtt tcaagatcac ctatgaggat ctggaggggg 14520 gcaacattcc cgcgctcctt gatctggacg cctacgagga gagcttgaaa cccgaggaga 14580 gcgctggcga cagcggcgag agtggcgagg agcaagccgg cggcggcggc agcgcgtcgg 14640 tagaaaacga aagtactccc gcagtggcgg cggacgctgc ggaggtcgag ccggaggcca 14700 tgcagcagga cgcagaggag ggcgcgcagg aggacatgaa caatggggag atcaggggcg 14760 acactttcgc cacccggggc gaagaaaaag aggcagaggc ggcggcggcg acggcggaag 14820 ccgaaaccga ggcagaggca gagcccgaga ccgaagttat ggaagacatg aatgatggag 14880 aacgtagggg tgacacgttt gccacccggg gcgaagagaa ggcggcggag gcagaagccg 14940 cggctgagga ggcggctgcg gctgcggcca aggctgaggc tgcggctgag gctaaggtcg 15000 aagccgatgt tgcggttgag gctcaggctg aggaggaggc ggcggctgaa gcagttaagg 15060 aaaaggccca ggcagagcag gaagagaaaa aacctgtcat tcaacctcta aaagaagata 15120 gcaaaaagcg cagttacaac gtcattgagg gcagcacctt tacccaatac cgcagctggt 15180 acctggctta caactacggc gacccggtca agggggtgcg ctcgtggacc ctgctctgca 15240 cgccggacgt cacctgcggc tccgagcaga tgtactggtc gctgccaaac atgatgcaag 15300 acccggtgac cttccgttcc acgcggcagg ttagcaactt tccggtggtg ggcgccgaac 15360 tgctgccagt acactccaag agtttttaca acgagcaggc cgtctactcc cagctgatcc 15420 gccaggccac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15480 gcccgccggc ccccaccatc accaccgtca gtgaaaacgt tcctgccctc acagatcacg 15540 ggacgctacc gctgcgcaac agcatctcag gagtccagcg agtgaccatt actgacgcca 15600 gacgccggac ctgcccctac gtttacaagg ccttgggcat agtctcgccg cgcgtcctct 15660 ccagtcgcac tttttaaaac acatccaccc acacgctcca aaatcatgtc cgtactcatc 15720 tcgcccagca acaacaccgg ctgggggctg cgcgcaccca gcaagatgtt tggaggggca 15780 aggaagcgct ccgaccagca ccccgtgcgc gtgcgcggcc actaccgcgc gccctggggt 15840 gcgcacaagc gcgggcgcac agggcgcacc actgtggatg atgtcattga ctccgtagtg 15900 gagcaggcgc gccactacac acccggcgcg ccgaccgcct ccgccgtgtc caccgtggac 15960 caggcgatcg aaagcgtggt acagggggcg cggcactatg ccaaccttaa aagtcgccgc 16020 cgccgcgtgg cgcgccgcca tcgccggaga ccccgggcta ctgccgccgc gcgccttacc 16080 aaggctctgc tcaagcgcgc caggcgaact ggccaccggg ccgccatgag ggccgcacgg 16140 cgggctgccg ctgccgcgag cgccgtggcc ccgcgggcac gaaggcgcgc ggccgctgcc 16200 gccgccgccg ccatttccag cttggcctcg acgcggcgcg gtaacatata ctgggtgcgc 16260 gactcggtga gcggcacacg tgtgcccgtg cgctttcgcc ccccacggaa ttagcacaag 16320 acaacataca cactgagtct cctgctgttg tgtatcccag cggcgaccgt cagcagcggc 16380 gacatgtcca agcgcaaaat taaagaagag atgctccagg tcatcgcgcc ggagatctat 16440 gggcccccga agaaggagga ggaggattac aagccccgca agctaaagcg ggtcaaaaag 16500 aaaaagaaag atgatgacgt tgacgaggcg gtggagtttg tccgccgcat ggcgcccagg 16560 cgccctgtgc agtggaaggg tcggcgcgtg cagcgagtcc tgcgccccgg caccgcggtg 16620 gtctttacgc ccggcgagcg ttccacgcgc actttcaagc gggtgtacga tgaggtgtac 16680 ggcgacgagg atctgttgga gcaggccaac catcgatttg gggagtttgc atatgggaaa 16740 cggcctcgcg agagtctaaa agaggacctg ctggcgctac cgctggacga gggcaatccc 16800 accccgagtc tgaagccggt gaccctgcaa caggtgctgc ctttgagcgc gcccagcgag 16860 cagaagcgag ggttaaagcg cgagggcggg gacctggcac ccaccgtgca gttgatggtg 16920 cccaagcggc agaagctgga ggacgtgctg gagaaaatga aagtagagcc cgggatccag 16980 cccgagatca aggtccgccc tatcaagcag gtggcgcccg gcgtgggagt ccagaccgtg 17040 gacgttagga ttcccacgga ggagatggaa acccaaaccg ccactccctc ttcggcagca 17100 agcgccacca ccggcgccgc ttcggtagag gtgcagacgg acccctggct acccgccgcc 17160 actatcgccg tcgccgccgc cccccgttcg cgcggacgca agagaaatta tccagcggcc 17220 agcgcgctta tgccccagta tgcgctgcat ccatccatcg cgcccacccc cggctaccgc 17280 gggtactcgt accgcccgcg cagatcagcc ggcactcgcg gccgccgccg ccgtgcgacc 17340 acaaccagcc gccgccgtcg ccgccgccgc cagccagtgc tgacccccgt gtctgtaagg 17400 aaggtggctc gctcggggag cacgctggtg gtgcccagag cgcgctacca ccccagcatc 17460 gtttaaagcc ggtctctgta tggttcttgc agatatggcc ctcacttgtc gccttcgctt 17520 cccggtgccg ggataccgag gaagaactca ccgccgcagg ggcatggcgg gcagcggtct 17580 ccgcggcggc cgtcgccatc gccggcgcgc aaagagcagg cgcatgcgcg gcggtgtgtt 17640 gcccctgctg gtcccgctac tcgccgcggc gatcggcgcc gtgcccggga tcgcctccgt 17700 ggccctgcag gcgtcccaga aacattgact cttgcaacct tgcaagcttg catttttgga 17760 ggaaaaaata aaaaagtcta gactctcacg ctcgcttggt cctgtgacta ttttgtagaa 17820 aaaagatgga agacatcaac tttgcgtcgc tggccccgcg tcacggctcg cgcccgttca 17880 tgggagactg gacagatatc ggcaccagca atatgagcgg tggcgccttc agctggggca 17940 gtctgtggag cggccttaaa aattttggtt ccaccattaa gaactatggc aacaaagcgt 18000 ggaacagcag cacgggtcag atgctgagag acaagttgaa agagcagaac ttccaggaga 18060 aggtggcgca gggcctggcc tctggcatca gcggggtggt ggacatagct aaccaggccg 18120 tgcagaaaaa gataaacagt catctggacc cccgccctca ggtggaggaa acgcctccag 18180 ccatggagac ggtgtctccc gagggcaaag gcgaaaagcg cccgcggccc gacagggaag 18240 agaccctggt gtcacacacc gaggagccgc cctcttacga ggaggcagtc aaggccggcc 18300 tgcccaccac tcgccccata gctcccatgg ccaccggtgt ggtgggtcac aggcaacaca 18360 cccccgcaac actagatctg cccccgccgt ccgagccgac tcgccagcca aaggcggtga 18420 cggtgtccgc tccctccact tccgccgcca acagagtgcc tctgcgccgc gctgcgagcg 18480 gcccccgggc ctcgcgagtc agcggcaact ggcagagcac actgaacagc atcgtgggcc 18540 tgggagtgag gagtgtgaag cgccgccgtt gctactgaat gagcaagcta gctaacgtgt 18600 tgtatgtgtg tatgcgtcct atgtcgccgc cagaggagct gttgagccgc cggcgccgtc 18660 tgcactccag cgaatttcaa gatggcgacc ccatcgatga tgcctcagtg gtcgtacatg 18720 cacatctcgg gccaggacgc ttcggagtac ctgagccccg ggctggtgca gttcgcccgc 18780 gccacagaca cctacttcaa catgagtaac aagttcagga accccactgt ggcgcccacc 18840 cacgatgtga ccacggaccg gtcgcagcgc ctgacgctgc ggttcatccc cgtggatcgg 18900 gaggacaccg cttactctta caaggcgcgg ttcacgctgg ccgtgggcga caaccgcgtg 18960 ctggacatgg cctccactta ctttgacatc cggggggtgc tggacagggg ccccactttt 19020 aagccctact cgggcactgc ctacaacccc ctggccccca agggcgcccc caattcttgt 19080 gagtgggaac aagaggaaaa tcaggtggtc gctgcagatg atgaacttga agatgaagaa 19140 gcgcaagcac aagaggaagc ccctgtgaaa aaaattcatg tatatgctca ggcgcctctt 19200 tctggcgaaa agatttccaa ggatggtatc caaataggta ctgaagtcgt aggagataca 19260 tctaaggaca cttttgcaga taaaacattc caacccgaac ctcagatagg cgagtctcag 19320 tggaacgagg ctgatgccac agcagcagga ggtagagttt tgaaaaagac tacccctatg 19380 agaccttgct atggatccta tgccaggcct accaatgcca acgggggtca aggaattatg 19440 gttgccaatg aacaaggagt gttggagtct aaagtagaaa tgcaattttt ctctaacacc 19500 acaaccctta atgcgcggga tggaaccggc aatcccgaac caaaggtggt gttgtacagc 19560 gaagatgtcc acttggaatc tcccgatact catctgtctt acaagcccaa aaaggatgat 19620 gttaatgcca aaatcatgtt gggtcagcaa gccatgccca acagacccaa cctcattgga 19680 tttagagata atttcattgg gcttatgttt tacaacagca ccggtaacat gggagtgctg 19740 gcgggtcagg cctctcagtt gaatgctgtg gtggacttgc aggatagaaa cacagaactg 19800 tcatatcagc ttctgcttga ttcaattggg gatagaacca gatacttctc catgtggaac 19860 caggcagtgg atagctatga tccagatgtc agaattattg aaaaccatgg gactgaggat 19920 gaactgccca actactgctt ccctttgggc ggcataggag ttactgatac ttatcaaggg 19980 ataaaaaata ccaatggcaa tggtcagtgg accaaagatg atcagttcgc ggaccgcaac 20040 gaaatagggg tgggaaacaa cttcgccatg gagatcaaca tccaggccaa cctttggaga 20100 aacttcctct atgcaaacgt ggggctctac ctgccagaca agctcaagta caaccccacc 20160 aacgtggaca tctctgacaa ccccaacacc tatgactaca tgaacaagcg ggtggtggcc 20220 cctggcctgg tggactgctt tgtcaatgtg ggagccaggt ggtccctgga ctacatggac 20280 aacgtcaacc ccttcaacca ccaccgcaat gcgggtctgc gctaccgctc catgatcctg 20340 ggcaacgggc gctatgtgcc ctttcacatc caggtacccc agaagttctt tgccatcaag 20400 aacctcctgc tcctgcccgg ctcctacacc tacgagtgga acttcaggaa ggatgtgaac 20460 atggtcctac agagctctct gggcaatgac cttagggtgg atggggccag catcaagttt 20520 gacagcatca ccctctatgc tacatttttc cccatggccc acaacaccgc ctccacgctt 20580 gaggccatgc tgagaaacga caccaacgac cagtccttta atgactacct ctctggggcc 20640 aacatgctct acccaatccc agccaaggcc accaacgtgc ccatctccat cccctctcgc 20700 aactgggccg cctttagagg ctgggccttt acccgcctta agaccaagga gaccccctcc 20760 ctgggctcgg gttttgatcc ctactttgtt tactcgggat ccatccccta cctggatggc 20820 accttctacc tcaaccacac tttcaagaag atatccatca tgtatgactc ctccgtcagc 20880 tggccgggca acgaccgctt gctcaccccc aatgagttcg aggtcaagcg cgccgtggac 20940 ggcgagggct acaacgtggc ccagtgcaac atgaccaagg actggttcct ggtgcagatg 21000 ctggccaact acaacatagg ctaccagggc ttttacatcc cagagagcta caaggacagg 21060 atgtactcct tcttcagaaa tttccaaccc atgagccgac aggtggtgga cgagaccaat 21120 tacaaggact atcaagccat tggcatcacc caccagcaca acaactcggg tttcgtgggc 21180 tacctggcgc ccaccatgcg cgagggtcag gcctaccccg ccaacttccc ctaccccttg 21240 ataggcaaga ccgcggtcga cagcgtcacc cagaaaaagt tcctctgcga ccgcaccctc 21300 tggcgcatcc ccttctctag caacttcatg tccatgggtg cgctcacgga cctgggccaa 21360 aacctgcttt atgccaactc tgcccatgcg ctggacatga cttttgaggt ggaccccatg 21420 gacgagccca cccttctcta tattgtgttt gaagtgttcg acgtggtcag agtgcaccag 21480 ccgcaccgcg gtgtcatcga gaccgtgtac ctgcgtacgc ccttctcagc cggcaacgcc 21540 accacctaag gagacagcgc cgccgccgcc tgcatgacgg gttccaccga gcaagagctc 21600 agggccattg ccagagacct gggatgcgga ccctattttt tgggcaccta tgacaaacgc 21660 ttcccgggct ttatctcccg agacaagctc gcctgcgcca ttgtcaacac ggccgcgcgc 21720 gagaccgggg gcgtgcactg gctggccttt ggctgggacc cgcgctccaa aacttgctac 21780 ctctttgacc cctttggctt ctccgatcag cgcctcaggc agatttatga gtttgagtac 21840 gaggggctgc tgcgccgcag cgcgctcgcc tcctcgcccg accgctgcat cacccttgag 21900 aagtccaccg aaaccgtgca ggggccccac tcggccgcct gcggtctctt ctgttgcatg 21960 tttttgcacg cctttgtgca ctggcctcag agtcccatgg attgcaaccc caccatgaac 22020 ttgctaaagg gagtgcccaa cgccatgctc cagagccccc aggtccagcc caccctgcgc 22080 cgcaaccagg aacagcttta ccgcttcctg gagcgccact ccccctactt ccgcagccac 22140 agcgcgcgca tccggggggc cacctctttt tgccacttgc aagaaaacat gcaagacgga 22200 aaatgatgta cagcatgctt ttaataaatg taaagactgt gcactttaat tatacacggg 22260 ctctttctgg ttatttattc aacaccgccg tcgccattta gaaatcgaaa gggttctgcc 22320 gtgcgtcgcc gtgcgccacg ggcagagaca cgttgcgata ctggaagcgg ctcgcccact 22380 tgaactcggg caccaccatg cggggcagtg gttcctcggg gaagttctcg ctccacaggg 22440 tgcgggtcag ctgcagcgcg ctcaggaggt cgggagccga gatcttgaag tcgcagttgg 22500 ggccggaacc ctgcgcgcgc gagttgcggt acacggggtt gcagcactgg aacaccagca 22560 gggccggatt attcacgctg gccagcaggc tctcgtcgct gatcatgtcg ctgtccagat 22620 cctccgcgtt gctcagggcg aatggggtca tcttgcagac ctgcctgccc aggaaaggcg 22680 ggagcccagg cttgccgttg cagtcgcagc gcaggggcat tagcaggtgc ccacggcccg 22740 actgcgcctg cgggtacaac gcgcgcatga aggcttcgat ctgcctaaaa gccacctggg 22800 tcttggctcc ctccgaaaag aacatcccac aggacttgct ggagaactgg ttcgcgggac 22860 agctggcatc gtgcaggcag cagcgcgcgt cagtgttggc aatctgcacc acgttgcgac 22920 cccaccggtt tttcactatc ttggccttgg aagcctgctc ctttagcgcg cgctggccgt 22980 tctcgctggt cacatccatc tctatcacct gttccttgtt gatcatgttt gtcccgtgca 23040 gacactttag gtcgccctcc gtctgggtgc agcggtgctc ccacagcgcg caaccggtgg 23100 gctcccaatt cttgtgggtc acccccgcgt aggcctgcag gtaggcctgc aggaagcgcc 23160 ccatcatggt cataaaggtc ttctggctcg taaaggtcag ctgcaggccg cgatgctctt 23220 cgttcagcca ggtcttgcag atggcggcca gcgcctcggt ctgctcgggc agcatcttaa 23280 aatttgtctt caggtcgtta tccacgtggt acttgtccat catggcacgc gccgcctcca 23340 tgcccttctc ccaggcggac accatgggca ggcttagggg gtttatcact tccagcggcg 23400 aggacaccgt actttcgatt tcttcttcct ccccctcttc ccggcgcgcg cccccgctgt 23460 tgcgcgctct taccgcctgc accaaggggt cgtcttcagg caagcgccgc accgagcgct 23520 tgccgccctt gacctgcttg atcagtaccg gcgggttgct gaagcccacc atggtcagcg 23580 ccgcctgctc ttcttcgtct tcgctgtcta ccactatttc tggggagggg cttctccgct 23640 ctgcggcaaa ggcggcggat cgcttctttt ttttcttggg agccgccgcg atggagtccg 23700 ccacggcgac cgaggtcgag ggcgtggggc tgggggtgcg cggtaccagg gcctcgtcgc 23760 cctcggactc ttcctctgac tccaggcggc ggcggagtcg cttctttggg ggcgcgcgcg 23820 tcagcggcgg cggagacggg gacggggacg gggacgggac gccctccaca gggggtggtc 23880 ttcgcgcaga cccgcggccg cgctcggggg tcttctcgcg ctggtcttgg tcccgactgg 23940 ccattgtatc ctcctcctcc taggcagaga gacataagga gtctatcatg caagtcgaga 24000 aggaggagag cttaaccacc ccctcagaga ccgccgatgc gcccgccgtc gccgtcgccc 24060 ccgctaccgc cgacgcgccc gccacaccga gcgacacccc cacggacccc cccgccgacg 24120 cacccctgtt cgaggaagcg gccgtggagc aggacccggg ctttgtctcg gcagaggagg 24180 atttgcaaga ggaggagaat aaggaggaga agccctcagt gccaaaagat cataaagagc 24240 aagacgagca cgacgcagac gcacaccagg gtgaagtcgg gcggggggac ggagggcatg 24300 gcggcgccga ctacctagac gaaggaaacg acgtgctctt gaagcacctg catcgtcagt 24360 gcgccatcgt ctgcgacgct ctgcaggagc gcagcgaggt gcccctcagc gtggcggagg 24420 tcagccgcgc ctacgagctc agcctctttt ccccccgggt gcccccccgc cgccgcgaaa 24480 acggcacatg cgagcccaac ccgcgcctca acttctaccc cgcctttgtg gtgcccgagg 24540 tcctggccac ctatcacatc ttctttcaaa attgcaagat ccccatctcg tgccgcgcca 24600 accgtagccg cgccgataag atgctggccc tgcgccaggg cgaccacata cctgatatcg 24660 ccgctttgga agatgtgcca aagatcttcg agggtctggg gcgcaacgag aagcgggcag 24720 caaactctct gcaacaggaa aacagcgaaa atgagagtca cactggagcg ctggtggagc 24780 tggagggcga caacgcccgc ctggcggtgc tcaagcgcag catcgaggtc acccactttg 24840 cctaccccgc gctcaacctg ccccccaaag tcatgaacgc ggtcatggac gggctgatca 24900 tgcgccgcgg ccggcccctc gctccagatg caaacttgca tgaggagacc gaggacggtc 24960 agcccgtggt cagcgacgag cagctgacgc gctggctgga gagcgcggac cccgccgaac 25020 tggaggagcg gcgcaagatg atgatggccg cggtgctggt caccgtagag ctggagtgtc 25080 tgcagcgctt cttcggtgac cccgagatgc agagaaaggt cgaggagacc ctacactaca 25140 ccttccgcca gggctacgtg cgccaggctt gcaagatctc caacgtggag ctcagcaacc 25200 tggtgtccta cctgggcatc ttgcatgaaa accgccttgg gcagagcgtg ctacactcca 25260 ccctgcgcgg ggaggcgcgc cgcgactacg tgcgcgactg cgtttacctc ttcctctgct 25320 acacctggca gacggccatg ggggtctggc agcagtgcct ggaggagcgc aacctcaagg 25380 agctggagaa gcttctgcag cgcgcgctca aagacctctg gacgggcttc aacgagcgct 25440 cggtggccgc cgcgctagcc gacctcatct tccccgagcg cctgctcaaa accctccagc 25500 aggggctgcc cgacttcacc agccaaagca tgttgcaaaa ttttaggaac tttatcctgg 25560 agcgttctgg catcctaccc gccacctgct gcgccctgcc cagcgacttt gtccccctcg 25620 tgtaccgcga gtgccccccg ccgctgtggg gccactgcta cctgttccaa ctggccaact 25680 acctgtccta ccacgcggac ctcatggagg actccagcgg cgaggggctc atggagtgcc 25740 actgccgctg caacctctgc acgccccacc gctccctggt ctgcaacacc caactgctca 25800 gcgagagtca gattatcggt accttcgagc tacagggtcc gtcctcctca gacgagaagt 25860 ccgcggctcc ggggctaaaa ctcactccgg ggctgtggac ttccgcctac ctgcgcaaat 25920 ttgtacctga agactaccac gcccacgaaa tcaggtttta cgaggaccaa tcccgcccgc 25980 ccaaggcgga gctgaccgcc tgcgtcatca cccagggcga gatcctaggc caattgcaag 26040 ccatccaaaa agcccgccaa gagtttttgc tgaagagggg tcggggggtg tatctggacc 26100 cccagtcggg tgaggagctc aacccggttc ccccgctgcc accgccgcgg gaccttgctt 26160 cccaggataa gcatcgccat ggctcccaga aagaagcagc agcggccgcc gctgccgccg 26220 ccccacatgc tggaggaaga ggaggaatac tgggacagtc aggcagagga ggtttcggac 26280 gaggaggagc cggagacgga gatggaagag tgggaggagg acagcttaga cgaggaggct 26340 tccgaagccg aagaggcagg cgcaacaccg tcaccctcgg ccgcagcccc ctcgcaggcg 26400 cccccgaagt ccgctcccag catcagcagc aacagcagcg ctataacctc cgctcctcca 26460 ccgccgcgac ccacggccga ccgcagaccc aaccgtagat gggacaccac cggaaccggg 26520 gccggtaagt cctccgggag aggcaagcaa gcgcagcgcc aaggctaccg ctcgtggcgc 26580 gctcacaaga acgccatagt cgcttgcttg caagactgcg gggggaacat ctccttcgcc 26640 cgccgcttcc tgctcttcca ccacggtgtg gccttccccc gtaacgtcct gcattactac 26700 cgtcatctct acagccccta ctgcggcggc agtgagccag aggcggccag cggcggcggc 26760 gcccgtttcg gtgcctagga agacccaggg caagacttca gccaagaaac tcgcggcgac 26820 cgcggcgaac gcggtcgcgg gggccctgcg cctgacggtg aacgaacccc tgtcgacccg 26880 cgaactgagg aaccgaatct tccccactct ctatgccatc ttccagcaga gcagagggca 26940 ggatcaggaa ctgaaagtaa aaaacaggtc tctgcgctcc ctcacccgca gctgtctgta 27000 tcacaagagc gaagaccagc ttcggcgcac gctggaggac gctgaggcac tcttcagcaa 27060 atactgcgcg ctcactctta aggactagct ccgcgccctt ctcgaattta ggcgggaacg 27120 cctacgtcat cgcagcgccg ccgtcatgag caaggacatt cccacgccat acatgtggag 27180 ctatcagccg cagatgggac tcgcggcggg cgcctcccaa gactactcca cccgcatgaa 27240 ctggctcagt gccggcccac acatgatctc acaggttaat gacatccgca cccatcgaaa 27300 ccaaatattg gtgaagcagg cggcaattac caccacgccc cgcaataatc ccaaccccag 27360 ggagtggccc gcgtccctgg tgtatcagga aattcccggc cccaccaccg tactacttcc 27420 gcgtgattcc caggccgaag tccaaatgac taactcaggg gcacagctcg cgggcggctg 27480 tcgtcacagg gtgcggcctc ctcgccaggg tataactcac ctggagatcc gaggcagagg 27540 tattcagctc aacgacgagt cggtgagctc ctcgctcggt ctcagacctg acgggacctt 27600 ccagatagcc ggagccggcc gatcttcctt cacgccccgc caggcgtacc tgactctgca 27660 gagctcgtcc tcggcgccgc gctcgggcgg catcgggact ctccagttcg tgcaggagtt 27720 tgtgccctcg gtctacttca accccttctc gggctctccc ggtcgctacc cggaccagtt 27780 tatcccgaac tttgacgccg cgagggactc ggtggacggc tacgactgaa tgtcgggtgg 27840 acccggtgca gagcaacttc gcctgaagca ccttgaccac tgccgccgcc ctcagtgctt 27900 tgcccgctgt cagaccggtg agttccagta cttttccctg cccgactcgc acccggacgg 27960 cccggcgcac ggggtgcgct ttttcatccc gagtcaggtc cgctctaccc taatcaggga 28020 gttcaccgcc cgtcccctac tggcggagtt ggaaaagggg ccttctatcc taaccattgc 28080 ctgcatttgc tctaaccctg gattacacca agatctttgc tgtcatttgt gtgctgagta 28140 taataaaggc tgagatcaga atctactcgg accttatccc tttcaattga tcataactgt 28200 aatcaataaa aaatcactta cttgaaatct gatagcaaga ctctgtccaa ttttttcagc 28260 aacacttcct tcccctcctc ccaactctgg tactctaggc gcctcctagc tgcaaacttc 28320 ctccacagtc tgaagggaat gtcagattcc tcctcctgtc cctccgcacc cacgatcttc 28380 atgttgttac agatgaaacg cgcgagatcg tctgacgaga ccttcaaccc cgtgtacccc 28440 tacgataccg agatcgctcc gacttctgtc cctttcctta cccctccctt tgtatcatcc 28500 gcaggaatgc aagaaaatcc agctggggtg ctgtccctgc acctgtcaga gccccttacc 28560 acccacaatg gggccctgac tctaaaaatg gggggcggcc tgaccctgga caaggaaggg 28620 aatctcactt cccaaaacat caccagtgtc gatccccctc tcaaaaaaag caagaacaac 28680 atcagccttc agaccgccgc acccctcgcc gtcagctccg gggccctaac cctttttgcc 28740 actccccccc tagcggtcag tggcgacaac cttactgtgc agtctcaggc ccctcttact 28800 ttggaagact caaaactaac tctggccacc aaaggacccc taactgtgtc cgaaggcaaa 28860 cttgtcctag aaacagagcc tcccctgcat gcaagtgaca gcagtagcct gggccttagc 28920 gtcacggccc cacttagcat taacaatgac agcctaggac tagacatgca agcgcccatc 28980 agctctcgag atggaaaact ggctctaaca gtggcggccc ccctaactgt ggccgagggt 29040 atcaatgctt tggcagtagc cacaggtaat ggtattggac taaatgaaac caacacacac 29100 ctgcaggcaa aactggtcgc gcccctaggc tttgatacca acggcaacat taagctaagc 29160 gtcgcaggag gcatgaggct aaacaataac acactgatac tagatgtaaa ctacccattt 29220 gaggctcaag gccaactgag cctaagagtg ggctcgggcc cactatatgt agattctagt 29280 agtcataacc taaccattag atgccttagg ggattgtatg taacatcttc taacaaccaa 29340 aacggtctag aggccaacat taaactaaca aaaggccttg tgtatgacgg aaatgccata 29400 gcagttaatg ttggcaaagg gctggaatac agccctactg gcacaacaga aaaacctata 29460 cagactaaaa taggtctagg catggagtat gacactgagg gagccatgat gacaaaacta 29520 ggctctggac taagctttga caattcagga gccattgtgg tgggaaacaa aaatgatgac 29580 aggcttactt tgtggaccac accggaccca tcgcccaact gtcagattta ctctgaaaaa 29640 gatgctaaac taaccttggt actgactaaa tgtggcagtc aggttgtagg cacagtatct 29700 attgccgctc ttaaaggtag ccttgtgcca atcactagtg caatcagtgt ggttcagata 29760 tacctaaggt ttgatgaaaa tggggtgctg atgagtaact cttcacttaa tggcgaatac 29820 tggaatttta gaaacggaga ctcaactaat ggcacaccat atacaaacgc agtgggtttt 29880 atgcctaatc tactggccta tcctaaaggt caaactacaa ctgcaaaaag taacattgtc 29940 agccaggtct acatgaacgg ggacgatact aaacccatga catttacaat caacttcaat 30000 ggccttagtg aaacagggga tacccctgtc agtaaatatt ccatgacatt ctcatggagg 30060 tggccaaatg gaagctacat agggcacaat tttgtaacaa actcctttac tttctcctac 30120 atcgcccaag aataaagaaa gcacagagat gcttgttttt gatttcaaaa ttgtgtgctt 30180 ttatttattt tcaagcttac agtatttcca gtagtcatta gaatagagct taattaaact 30240 gcatgagaac ccttccacat agcttaaatt atcaccagtg caaatggaaa aaaatcaaca 30300 taccttttta tccagatatc aaagaactct agtggtcagt tttcccccac cctcccagct 30360 cacagaatac acagtccttt ccccccggct ggctttaaac aacactatct cattggtaac 30420 agacatattt ttaggtgtaa taatccacac ggtctcttgg cgggccaaac gctggtctgt 30480 gatgttaata aactccccag gcagctcttt caagttcacg tcgctgtcca actgctgaag 30540 cgctcgcggc tccgactgcg cctctagcgg aggcaacggc agcacccgat ccttgatcta 30600 taaaggagta gagtcataat cccccataag aatagggcgg tgatgcagca acaaggcgcg 30660 cagcaactcc tgccgccgcc tctccgtacg acaggaatgc aacggggtgg tggtctcctc 30720 cgcgataatc cgcaccgctc gcagcatcag catcctcgtc ctccgggcac agcagcgcat 30780 cctgatctca ctgagatcgg cgcagtaagt gcagcacaac accaagatgt tatttaagat 30840 cccacagtgc aaagcactgt acccaaagct catggcggga aggacagccc ccacgtgacc 30900 atcgtaccag atcctcaggt aaatcaaatg acgacctctc ataaacacgc tggacatata 30960 catcacctcc ttgggcatga gctgattcac cacctctcga taccacaggc atcgctgatt 31020 aattaaagac ccctcgagca ccatcctgaa ccaggaagcc agcacctgac cccccgccag 31080 gcactgcagg gaccccggtg aatcgcagtg gcagtgaaga ctccagcgct cgtagccgtg 31140 aaccatagag ctggtcatta tatccacatt ggcacaacac agacacactt tcatacactt 31200 tttcatgatt agcagctcct ctctagtcaa gaccatatcc caaggaatca cccactcttg 31260 aatcaaggta aatcccacac agcagggcag gcctctcaca taactcacgt tatgcatagt 31320 gagcgtgtcg caatctggaa ataccggatg atcttccatc accgaagccc gggtctccgt 31380 ctcaaaggga ggtaaacggt ccctcgtgta gggacagtgg cgggataatc gagatcgtgt 31440 tgaacgtaga gtcatgccaa agggaacagc ggacgtactc atatttcctc cagcagaacc 31500 aagtgcgcgc gtggcagcta tccctgcgtc ttctgtctcg ccgcctgccc cgctcggtgt 31560 agtagttgta atacagccac tccctcagac cgtcaaggcg ctccctggcg tccggatcta 31620 taacaacacc gtcctgcagc gccgccctga tgacatccac caccgtagag tatgccaagc 31680 ccagccacga aatgcactca ctttgacagc gagagatagg aggagcggga agagatggaa 31740 gaaccatgat agtaaaagaa cttttattcc aatcgatcct ctacaatgtc aaagtgtaga 31800 tctatcagat ggcactggtc tcctccgctg agtcgatcaa aaataacagc taaaccacaa 31860 acaacacgat tggtcaaatg ctgcacaagg gcttgcagca taaaatcgcc tcgaaagtcc 31920 accgcaagca taacatcaaa gccaccgccc ctatcatgat ctatgataaa aaccccacag 31980 ctatccacca gacccatata gttttcatct ctccatcgtg aaaaaatatt tacaagctcc 32040 tcctttaaat cacctccaac caattcaaaa agttgagcca gaccgccctc caccttcatt 32100 ttcagcatgc gcatcatgat tgcaaaaatt caggctcctc agacacctgt ataagattga 32160 gaagcggaac gttaacatca atgtttcgct cgcgaagatc gcgcctcagt gcaagcatga 32220 tataatccca caggtcggag cggatcagcg aggacatctc cccgccagga accaactcaa 32280 cggagcctat gctgattata atacgcatat tcggggctat gctaaccagc acggccccca 32340 aataggcgta ctgcataggc ggcgacaaaa agtgaacagt ttgggttaaa aaatcaggca 32400 aacactcgcg caaaaaagca agaacatcat aaccatgctc atgcaaatag atgcaagtaa 32460 gctcaggaac gaccacagaa aaatgcacaa tttttctctc aaacatgact gcgagccctg 32520 caaaaaataa aaaagaaaca ttacacaaga gtagcctgtc ttacaatggg atagactact 32580 ctaaccaaca taagacgggc cacgacatcg cccgcgtggc cataaaaaaa attatccgtg 32640 tgattaaaaa gaagcacaga tagctggcca gtcatatccg gagtcatcac gtgcgaaccc 32700 gtgtagaccc ccgggttgga cacatcggcc aaacaaagaa agcggccaat gtatcccgga 32760 ggaatgataa cactaagacg aagatacaac agaataaccc catggggggg aataacaaag 32820 ttagtaggtg aataaaaacg ataaacaccc gaaactccct cctgcgtagg caaaatagcg 32880 ccctcccctt ccaaaacaac atacagcgct tccacagcag ccatgacaaa agactcaaaa 32940 cactcaaaag actcagtctt accaggaaaa taaaagcact ctcacagcac cagcactaat 33000 cagagtgtga agagggccaa gtgccgaacg agtatatata ggaattaaaa atgacgtaaa 33060 tgtgtaaagg tcaaaaaacg cccagaaaaa tacacagacc aacgcccgaa acgaaaaccc 33120 gcgaaaaaat acccagaagt tcctcaacaa ccgccacttc cgctttccca cgatacgtca 33180 cttcctcaaa aatagcaaac tacatttccc acatgtacaa aaccaaaacc cctccccttg 33240 tcaccgccca caacttacat aatcacaaac gtcaaagcct acgtcacccg ccccgcctcg 33300 ccccgcccac ctcattatca tattggcctc aatccaaaat aaggtatatt attgatgatg 33360 <210> 74 <211> 500 <212> PRT <213> Human immunodeficiency virus <400> 74 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Lys Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr Val Ala Thr Leu Tyr Cys Val His Gln Lys Ile Asp Val Lys Asp 85 90 95 Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Gly Thr Gly Asn Ser Ser Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala 210 215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330 335 Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 355 360 365 Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 370 375 380 Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Val Gly His 385 390 395 400 Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415 Gly Lys Glu Gly His Gln Met Lys Asp Cys Asn Glu Arg Gln Ala Asn 420 425 430 Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 435 440 445 Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455 460 Phe Gly Glu Glu Lys Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 465 470 475 480 Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser Leu Phe Gly Asn Asp 485 490 495 Pro Ser Ser Gln 500

Claims (15)

1. 다음을 포함하는 아데노바이러스 헥손 단백질을 인코딩하는 단리된 폴리뉴클레오타이드:
   A) (i) 서열번호 11에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 27 번이 A가 아닌 그의 변이체를 포함하는 HVR1,
   (ii) 서열번호 12에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 1 번이 L이 아닌 그의 변이체를 포함하는 HVR2,
   (iii) 서열번호 13에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 7 번이 V가 아닌 그의 변이체를 포함하는 HVR3,
   (iv) 서열번호 14에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR4,
   (v) 서열번호 15에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR5,
   (vi) 서열번호 16에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR6, 및
   (vii) 서열번호 17에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 1 번이 I가 아닌 그의 변이체를 포함하는 HVR7; 또는
   B) (i) 서열번호 18에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 8 번이 V가 아니고/아니거나, 12 번이 D가 아니고/아니거나, 13 번이 E가 아니고/아니거나, 14 번이 L이 아닌 그의 변이체를 포함하는 HVR1,
   (ii) 서열번호 19에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 10 번이 D가 아닌 그의 변이체를 포함하는 HVR2,
   (iii) 서열번호 20에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 6 번이 T가 아닌 그의 변이체를 포함하는 HVR3,
   (iv) 서열번호 21에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 9 번이 L이 아닌 그의 변이체를 포함하는 HVR4,
   (v) 서열번호 22에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 3 번이 T가 아닌 그의 변이체를 포함하는 HVR5,
   (vi) 서열번호 23에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 9 번이 I가 아닌 그의 변이체를 포함하는 HVR6, 및
   (vii) 서열번호 24에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 8 번이 I가 아닌 그의 변이체를 포함하는 HVR7; 또는
   C) (i) 서열번호 25에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR1,
   (ii) 서열번호 26에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR2,
   (iii) 서열번호 27에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 7 번이 V가 아닌 그의 변이체를 포함하는 HVR3,
   (iv) 서열번호 28에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 10 번이 E가 아닌 그의 변이체를 포함하는 HVR4,
   (v) 서열번호 29에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 3 번이 T가 아닌 그의 변이체를 포함하는 HVR5,
   (vi) 서열번호 30에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 9 번이 I가 아닌 그의 변이체를 포함하는 HVR6, 및
   (vii) 서열번호 31에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 8 번이 I가 아니고/아니거나, 11 번이 T가 아닌 그의 변이체를 포함하는 HVR7; 또는
   D) (i) 서열번호 32에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR1,
   (ii) 서열번호 33에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR2,
   (iii) 서열번호 34에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 6 번이 T가 아닌 그의 변이체를 포함하는 HVR3,
   (iv) 서열번호 35에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 6 번이 Q가 아니고/아니거나, 10 번이 E가 아닌 그의 변이체를 포함하는 HVR4,
   (v) 서열번호 36에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 3 번이 T가 아닌 그의 변이체를 포함하는 HVR5,
   (vi) 서열번호 37에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 1 번이 K가 아닌 그의 변이체를 포함하는 HVR6, 및
   (vii) 서열번호 38에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 8 번이 I가 아닌 그의 변이체를 포함하는 HVR7; 또는
   E) (i) 서열번호 39에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 27 번이 A가 아닌 그의 변이체를 포함하는 HVR1,
   (ii) 서열번호 40에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR2,
   (iii) 서열번호 41에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR3,
   (iv) 서열번호 42에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR4,
   (v) 서열번호 43에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR5,
   (vi) 서열번호 44에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 HVR6, 및
   (vii) 서열번호 45에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖고 1 번이 I가 아닌 그의 변이체를 포함하는 HVR7.
2. 제1항에 있어서, 헥손 단백질은 다음을 포함하는, 단리된 폴리뉴클레오타이드:
   A) 서열번호 46에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체,
   B) 서열번호 47에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체,
   C) 서열번호 48에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체,
   D) 서열번호 49에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체, 및/또는
   E) 서열번호 50에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체.
3. 제1항 또는 제2항에 있어서, 서열번호 51 또는 52에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 아데노바이러스 펜톤 단백질을 추가로 인코딩하는, 단리된 폴리뉴클레오타이드.
4. 제1항 내지 제3항 중 어느 한 항에 있어서, 서열번호 53 또는 54에 따른 아미노산 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 아데노바이러스 섬유 단백질을 추가로 인코딩하는, 단리된 폴리뉴클레오타이드.
5. 제1항 내지 제4항 중 어느 한 항에 있어서, 서열번호 57에 따른 뉴클레오타이드 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 VA RNA II 비코딩 RNA; 및/또는 서열번호 55 또는 56에 따른 뉴클레오타이드 서열, 또는 적어도 85% 서열 동일성을 갖는 그의 변이체를 포함하는 VA RNA I 비코딩 RNA를 추가로 인코딩하는, 단리된 폴리뉴클레오타이드.
6. 제1항 내지 제5항 중 어느 한 항의 폴리뉴클레오타이드를 포함하는 아데노바이러스, 바람직하게는 복제-불능 아데노바이러스를 인코딩하는, 단리된 폴리뉴클레오타이드.
7. 제6항에 있어서, 아데노바이러스는 키메라 아데노바이러스이고/이거나, 비-아데노바이러스 유전자, 단백질 또는 그의 단편을 보유하는, 단리된 폴리뉴클레오타이드.
8. 제1항 내지 제4항 중 어느 한 항의 단리된 폴리뉴클레오타이드에 의해 인코딩되는 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드.
9. 제1항 내지 제7항 중 어느 한 항에 따른 단리된 폴리뉴클레오타이드 및/또는 제8항에 따른 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드를 포함하는 단리된 아데노바이러스, 바람직하게는 복제-불능 아데노바이러스.
10. 제1항 내지 제7항 중 어느 한 항의 단리된 폴리뉴클레오타이드에 의해 인코딩되는 바이러스-유사 입자.
11. 제1항 내지 제7항 중 어느 한 항의 단리된 폴리뉴클레오타이드를 포함하는 벡터.
12. (i) 애주번트; (ii) 제1항 내지 제7항 중 어느 한 항의 단리된 폴리뉴클레오타이드, 제8항의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제9항의 아데노바이러스, 제10항의 바이러스-유사 입자, 또는 제11항의 벡터; 및 선택적으로 (iii) 약제학적으로 허용 가능한 부형제를 포함하는 조성물.
13. 제1항 내지 제7항 중 어느 한 항의 폴리뉴클레오타이드, 제8항의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제9항의 아데노바이러스, 제10항의 바이러스-유사 입자, 또는 제11항의 벡터를 포함하는 세포.
14. 질병의 치료 또는 예방에 사용하기 위한 제1항 내지 제7항 중 어느 한 항의 폴리뉴클레오타이드, 제8항의 적어도 하나의 단리된 아데노바이러스 캡시드 폴리펩타이드, 제9항의 아데노바이러스, 제10항의 바이러스-유사 입자, 또는 제11항의 벡터 및/또는 제12항의 조성물.
15. (i) 제1항 내지 제7항 중 어느 한 항의 단리된 폴리뉴클레오타이드를 세포에서 발현시켜, 아데노바이러스 또는 아데노바이러스-유사 입자가 세포내에서 조립되는 단계; 및
    (ii) 세포 또는 세포 주위의 배지로부터 아데노바이러스 또는 아데노바이러스-유사 입자를 단리하는 단계
    를 포함하는 아데노바이러스 또는 아데노바이러스-유사 입자를 생성하는 시험관내(in vitro) 방법.

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