CN116323955A - 通过crispr/cas介导的体内末端解析拯救重组腺病毒 - Google Patents

通过crispr/cas介导的体内末端解析拯救重组腺病毒 Download PDF

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CN116323955A
CN116323955A CN202180067002.0A CN202180067002A CN116323955A CN 116323955 A CN116323955 A CN 116323955A CN 202180067002 A CN202180067002 A CN 202180067002A CN 116323955 A CN116323955 A CN 116323955A
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Z·鲁兹西奇
A·里德尔
J·菲舍尔
H-G·伯格特
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Abstract

本发明涉及用于拯救重组腺病毒的环状DNA分子，其包含重组腺病毒基因组，所述重组腺病毒基因组在基因组末端侧翼有两个反向末端重复序列(ITR)，其中至少一个ITR与相邻于PAM序列的靶序列相关联，其中靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，优选在小于约(15)个核苷酸内。本发明还涉及用于拯救重组腺病毒的试剂盒和方法，其包含或使用如本文所述的环状DNA分子。

Description

通过CRISPR/CAS介导的体内末端解析拯救重组腺病毒
技术领域
本发明涉及用于拯救重组腺病毒的环状DNA分子，其包含重组腺病毒基因组，所述重组腺病毒基因组在基因组末端侧翼有两个反向末端重复序列(ITR)，其中至少一个ITR与相邻于PAM序列的靶序列相关联，其中靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，优选在小于约15个核苷酸内。本发明还涉及用于拯救重组腺病毒的试剂盒和方法，其包含或使用如本文所述的环状DNA分子。
背景技术
腺病毒是线性双链DNA病毒，在细胞培养物中高效复制，重组腺病毒(rAd)载体是体外和体内基因转移应用中最常用的载体之一。rAd基因组已在大肠杆菌中构建，在那里它们的基因组可以以环状质粒1或细菌人工染色体(BAC)2,3的形式进行维持、繁殖和修饰。从源自大肠杆菌的环状形式拯救复制的rAd是有问题的，因为腺病毒复制避免了环状中间体，并且它们的线性基因组与末端蛋白(TP)共价连接4。腺病毒(Ad)基因组通过由反向末端重复序列(ITR)提供的末端复制起点(位于基因组末端的侧翼)和TP进行复制。因此，通常rAd质粒和BAC需要限制性核酸内切酶介导的线性化，并在通过转染拯救载体之前重新纯化5。这与基于其他DNA病毒的载体的拯救方法形成鲜明对比，例如腺相关病毒(AAV)载体，它们通过环状中间体复制，因此，它们的复制周期自然包括环状和线性基因组形式之间的转换(末端解析)。在此类载体中，拯救效率直接取决于转染效率，如WO2019/113310A1中所公开。
WO2019/113310A1描述了使用封闭式DNA拯救AAV的优势。然而，AAV是细小病毒，它们的生物学特性与腺病毒非常不同。与细小病毒相反，腺病毒在其复制周期中没有末端解析(terminal resolution)。因此，AAV拯救实验不能与腺病毒拯救实验相提并论，因为AAV拯救仅依赖于转染效率，不需要人工末端解析步骤(线性化)。对于基于腺病毒的载体，仅提高转染效率是不够的，因为除此之外还需要人工诱导末端解析。
线性DNA转染本身的效率低于共价闭合环状DNA的转染6,7。此外，为了从线性DNA重建腺病毒，还需要克服另一个瓶颈。在DNA复制开始之前，基因组末端需要从头TP结合，这不是天然腺病毒DNA复制周期的一部分8,9。
除了使用限制性核酸内切酶线性化的方法外，如果ITR彼此紧邻10，环状DNA只能被拯救用于rAd的产生。该技术的两个主要缺点是i)反向重复序列近邻处在细菌中可能不稳定，以及ii)它不允许在病毒拯救时从rAd基因组中去除细菌载体序列。因此，剩余的质粒序列要么占据该载体系统克隆能力的大约一半，要么需要付出额外的努力来去除这些序列10。此外，ITR融合仅应用于拯救基于物种C的rAd，尚无数据表明是否可以通过这种方式拯救基于其他Ad物种的载体。通过酶促线性化和ITR融合拯救病毒的效率相当10，但酶促线性化允许直接去除大多数细菌载体序列并适用于各种Ad物种。因此，现在只有酶促体外线性化用于重组rAd。然而，这种基于限制性核酸酶的应用的一个重要缺点是它们总是留下额外的核苷酸来掩盖ITR的末端。由于缺乏在ITR末端精确切割的方法，无法测试精确切割是否是拯救效率的重要因素。
US2002/136708A1描述了一种产生辅助依赖性腺病毒(HD-AdV)载体的方法。结果表明，病毒DNA可以在体内被切割，并且这种切割有效地抑制了目标基因组的繁殖。这与促进病毒繁殖的本发明的目的相反。
鉴于现有技术，本领域仍然非常需要提供从转染的环状DNA中有效拯救重组腺病毒的额外方法，这也提供了切割位点的灵活性。本领域已知的使用环状DNA的方法存在细菌中环状DNA分子不稳定和病毒拯救时无法从rAd基因组中去除细菌载体序列的缺点，而使用线性化DNA的方法的主要缺点是效率低下DNA转染到腺病毒生产细胞系中。
发明内容
鉴于现有技术，本发明的技术问题是提供从生产细胞系中有效拯救重组腺病毒的替代和/或改进方法，其中拯救的rAd不包含任何细菌载体序列。
该问题通过独立权利要求的特征解决。本发明的优选实施例由从属权利要求提供。
因此，本发明涉及用于拯救重组腺病毒的环状DNA分子，其包含重组腺病毒基因组，所述重组腺病毒基因组在基因组末端侧翼有两个反向末端重复序列(ITR)，其中
-至少一个ITR与相邻于PAM序列的靶序列相关联，其中
-靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。
本发明基于完全令人惊讶的想法，即，使用CRISPR/Cas机制切割环状DNA分子，以在分子以其环状形式转染后直接在宿主细胞中拯救包含重组腺病毒基因组rAd基因组的重组腺病毒。
CRISPR/Cas技术(Hille等人的综述11)是一种精确的基因组编辑技术，具有简洁的调控可能性11并已广泛应用于哺乳动物细胞12,13、病毒14,15和生物技术16,17的反向遗传学。CRISPR/Cas9复合物将双链断裂引入dsDNA底物，如果有基序，即所谓的PAM序列或只是它上游的“PAM”(Protospacer Adjacent Motif)。Cas9是一种多域蛋白，由一个识别结构域(REC)、楔形结构域(WED)、两个核酸酶域(分别为HNH核酸酶和RuvC样结构域)和一个PAM相互作用(PI)结构域组成18-20。单独的Cas9蛋白不显示核酸酶活性，因为RuvC样结构域以自动抑制方式阻断HNH核酸酶结构域21。如果Cas9通过其REC和WED结构域与sgRNA相关联，则发生向内切核酸酶活性状态的转变，通过sgRNA靶向DNA相互作用检测靶序列。当RNA-DNA杂交发生时，Cas9的RuvC样结构域正在切割编码用于PAM的链，而其HNH结构域则切割反义链。
使用CRISPR/Cas技术修饰病毒是一种巧妙的方法，提供了避免细菌克隆繁殖突变体的可能性14,15。然而，正如这些论文中清楚表明的那样，这种方法在创建突变体方面非常出色，但结果是i)永远不会克隆，并且ii)总是被野生型基因组污染。这两种遗传杂质中的任何一种在研究中都是可以接受的(如果无效表型占主导地位)，但在任何需要克隆和纯制剂的载体繁殖技术中都是不可接受的。因此，无法避免使用细菌克隆的病毒基因组，本发明利用RNA引导的DNA核酸内切酶将克隆形式转变为具有复制能力的DNA。避免了病毒基因组本身的修改。
CRISPR/Cas技术已被建议用于环状DNA(例如质粒DNA)的体外线性化(Jia-WangWang et al:"CRISPR/Cas9 nuclease cleavage combined with Gibson assembly forseamless cloning",Biotechniques,vol.58,no.4,1April 2015)。然而，由于已知基于限制性内切酶的体外线性化技术相对低效(见上文)，因此此类体外方法似乎对帮助拯救rAd没有吸引力。
在本发明的上下文中，优选为环状双链DNA分子的本发明的环状DNA分子包含与PAM序列相邻的靶序列。由于靶序列定位为与PAM相邻(相邻的意思是紧挨着，靶序列和PAM之间没有碱基)，靶序列可以被与Cas9相关的合适的sgRNA或技术人员已知的其他合适的RNA引导的DNA核酸内切酶。技术人员知道已建立的RNA引导的DNA核酸内切酶(例如Cas9)相对于PAM序列和靶序列位置的切割位点。因此，可以设计包含至少一个与PAM序列相邻的靶序列的环状DNA质粒，该PAM序列能够产生在相应ITR的紧邻外末端外部的由RNA引导的DNA核酸内切酶(例如Cas9)介导的DNA双链断裂(即切割)。
通过使用本发明的产品和方法，现在可以直接从其重组形式中拯救重组腺病毒而无需进一步操作。因此，该方法比重组腺病毒重组的传统方法更简单、更快速。然而，本发明的这项新技术的一个主要技术收获是病毒拯救比任何其他描述的rAd拯救技术更有效约30-50倍。这使得该技术成为更好的应用平台，这取决于初级病毒拯救，例如制备高含量载体库或繁殖基于质粒的高容量腺病毒载体。
在优选的实施例中，以某种方式选择和设计靶序列和PAM序列，使得切割直接发生在ITR的外末端外部，意味着直接发生在形成ITR的一部分的最后一个碱基对之后。在本发明的优选实施例中，两个ITR中的每一个都与相邻于PAM序列的靶序列相关联。据我们所知，本发明是第一种允许在病毒ITR的最末端从其环状形式精确切割rAd基因组的方法。
然而，如本文所用，术语“紧邻”涉及由RNA引导的核酸内切酶产生的位于ITR外末端外部0-40个碱基范围内的切割，例如在ITR外末端外部1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38或39个碱基。
在优选的实施例中，RNA引导的核酸内切酶产生的DNA切割位于相应ITR外末端外部25个核苷酸以内，更优选20个以内，甚至更优选15个，甚至更优选10个以内。从示例的数据中可以明显看出，至少对于一些ITR序列和相应的靶序列而言，拯救效率随着切割与ITR外末端的邻近程度的增加而增加。
在最优选的实施例中，一个或优选两个DNA双链断裂恰好在一个或优选两个相应的ITR的外末端产生。然而，如果DSB是在相应ITR的紧邻外末端外部产生的，特别是如果DSB在ITR外末端外部不到20个(例如ITR外末端外的19、18、17、16、15、14、13、12、11、10、9、8、7、6、5、4、3、2或1个)碱基内发生冲突，本发明也能很好地发挥作用。
在本发明的优选实施例中，两个ITR中的每一个都与相邻于PAM序列的靶序列相关联。
尽管已表明，PAM序列配置为在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，在该PAM序列存在相邻的一个靶序列足以能够通过Cas9进行细胞内加工后有效拯救重组腺病毒，事实证明，在两个ITR中的每一个外部诱导两个双链断裂导致从细胞中拯救病毒的效率更高。在此类实施例中，本发明的环状DNA分子包含的重组腺病毒基因组的两个ITR中的每一个都与靶序列和相邻的PAM相关联，它们配置为能够直接在ITR序列外部或紧邻处被RNA引导的核酸内切酶切割，如本文所定义。
在涉及其中两个ITR与相邻于PAM序列的靶序列相关联的本发明环状DNA分子的实施例中，与两个ITR相关联的相应靶序列是相同或不同的以拯救不同的rAd类型。
由于源自不同类型腺病毒的ITR序列大多不相同，因此通常不可能使用与PAM序列相邻的相同靶序列来直接在实际ITR外部产生RNA核酸内切酶介导的双链断裂，即直接在ITR在其外末端包含的最后一个碱基/碱基对外部。这种精确切割通常需要PAM和/或靶序列从而与环状DNA分子的ITR序列的外末端和相邻序列重叠，这取决于所采用的RNA引导的核酸内切酶的切割行为。
例如，在使用Cas9的情况下，双链断裂将发生在PAM序列上游的3-4个碱基处。因此，为了诱导Cas9的精确切割，PAM序列位于ITR内部的3个碱基或外部的3个碱基，而靶序列延伸到PAM的上游，其中包含ITR的最后3个碱基和额外的ITR的外部碱基ITR或包括ITR外的前3个碱基和ITR内的额外碱基。
因此，如果要在ITR外部进行精确切割，通常需要使用与不同类型腺病毒的ITR相关的两个不同靶序列，因为它们的ITR末端序列不同。
能够直接在两个ITR外部诱导双链断裂的此类实施例对于需要高效病毒拯救的应用来说非常有利。
在实施例中，PAM和/或靶序列与ITR的外末端至少部分重叠，其中优选地，靶序列配置用于在相应ITR的外末端产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。如果需要恰好在ITR外部进行精确切割，则此类实施例是有利的。在本发明的上下文中，PAM序列和靶序列形成连续序列，并且应理解，如果该连续序列延伸越过ITR和不属于重组腺病毒基因组一部分的环状DNA分子的相邻序列的边界，连续序列与ITR的外末端部分重叠。
然而，如示例所示，如果ITR外的双链断裂并非恰好发生在ITR外，而是在ITR外的ITR紧邻处，则rAd的有效拯救也是可能的。因此，有可能设计和基因改造本发明的环状DNA分子，其包含合适的相同靶序列，其优选位于ITR外部并且能够在ITR外部的几个核苷酸内切割，例如ITR外部的约6-7个核苷酸。
通过改造ITR外部的序列，可以提供环状DNA分子，其包含两个相同的靶序列，该靶序列与PAM相邻，PAM与DNA分子的两个ITR相关。因此，可以通过仅使用单个向导RNA(gRNA)将RNA引导的核酸内切酶引导至两个ITR以切割环状DNA分子并恰好在两个ITR外部提供dsDNA的游离末端，从而在分子的两个ITR外部诱导两个双链断裂。
一个很大的优势是，可以用与任何类型腺病毒的ITR相关的相同靶序列设计本发明的环状DNA分子，因为相同的靶序列和因此相同的gRNA可用于拯救衍生自不同类型腺病毒的rAd。
在实施例中，靶序列或PAM定位成相邻于ITR的外末端。在此类实施例中，环状DNA分子设计成以ITR外部的第一个核苷酸为靶序列的一部分，或优选是PAM的三个核苷酸中的第一个。例如，与ITR相邻的是PAM序列，紧接着是靶序列。在Cas9介导的切割的情况下，双链断裂将在ITR序列外部的6个核苷酸处产生。
在其他实施例中，靶序列和PAM序列在另一个方向上与ITR相邻排列，其中在ITR外部并与ITR相邻首先是靶序列，然后是PAM。可以以相同靶序列和PAM位于ITR序列外部和相邻处的方式工程化本发明的环状DNA分子。在PAM直接与ITR相邻，随后是靶序列的此类实施例中，这使得能够通过仅使用单个gRNA在每个ITR外约6个核苷酸处产生两个双链断裂。
如本文所用，术语“相邻”涉及彼此直接相邻而没有其他碱基位于其间的序列或碱基。因此，如果例如PAM定位成与ITR(的外末端)相邻，则这意味着ITR外部的第一个碱基不是ITR的一部分，而是PAM的一部分。
因此，在实施例中，与两个ITR相关的靶序列是相同的。
在本发明的上下文中，靶序列被称为与ITR相关联，靶序列连同相邻的PAM能够直接在相应ITR的外末端的外部或紧邻外部产生RNA核酸内切酶介导的双链断裂。
在本发明的实施例中，环状DNA分子是细菌人工染色体(BAC)。在这样的实施例中，重组腺病毒基因组被整合到更大的BAC中。使用这种基于BAC的环状DNA分子是有利的，因为BAC的克隆能力大，例如还能够递送DNA序列，从而能够在同一DNA分子中表达一个、两个或多个gRNA和/或Cas9或另一种合适的RNA引导的核酸内切酶分子。
在另一个实施例中，环状DNA分子是高拷贝质粒。此类实施例对于需要高质量DNA并将环状DNA分子的多个拷贝引入生产细胞的高效应用非常有利。在采用包含重组腺病毒基因组的环状高拷贝质粒的此类实施例中，可以优选在不同的DNA分子(例如其他质粒)上或者使用已经表达这些分子的生产细胞系提供gRNA和Cas9或另一种RNA引导的核酸内切酶编码序列。
在实施例中，环状DNA分子另外包含用于至少一种向导RNA(gRNA)的表达盒和/或用于产生DNA双链断裂的RNA引导的DNA内切核酸酶的表达盒，例如化脓性链球菌Cas9(SpCas9)，其中表达盒位于腺病毒基因组外部的两个ITR之间。例如，本发明的基于BAC的环状DNA分子具有足够的克隆能力，还可以在同一分子内提供此类表达盒，从而能够通过仅递送单个DNA分子在未修饰的生产细胞中生产rAd。
在本发明的实施例中，腺病毒基因组是人腺病毒载体基因组。
在进一步的实施例中，腺病毒基因组是猿猴(simian)腺病毒载体基因组。当使用重组腺病毒载体将基因递送给可能具有抗人腺病毒抗体的人类受试者时，使用猿猴腺病毒载体是有利的。猿猴载体不被此类现有抗体识别，因此不被宿主免疫系统识别。
在实施例中，腺病毒基因组是腺病毒载体基因组，例如第一代、第二代或第三代腺病毒载体基因组，优选包含至少一个转基因。
在实施例中，腺病毒基因组是第一代腺病毒载体基因组，优选包含至少一个转基因。在进一步的实施例中，腺病毒基因组是第二代或第三代腺病毒载体基因组，优选包含至少一种转基因。
本发明进一步涉及一种用于拯救重组腺病毒的试剂盒，其包含
a.环状DNA分子或发明，
和
b.RNA引导的DNA核酸内切酶或编码RNA引导的DNA核酸内切酶的核酸分子，
c.一种或多种gRNA或编码一种或多种gRNA的一种或多种核酸分子，用于将RNA引导的DNA核酸内切酶靶向环状DNA分子的靶向序列，
和/或
d.适用于拯救重组腺病毒(生产细胞)的细胞，例如293细胞或A549细胞。
应当理解，编码RNA引导的DNA内切核酸酶或编码gRNA的核酸分子是能够表达RNA引导的DNA内切核酸酶或gRNA的核酸分子，例如包含相应表达盒的核酸分子，其中这样的表达盒包含可操作地连接至介导编码序列的转录和表达的启动子和/或增强子序列的编码序列。
在实施例中，本发明的试剂盒包含适用于拯救重组腺病毒的细胞，其中细胞表达RNA引导的DNA核酸内切酶，优选SpCas9。
此外，本发明还涉及体外拯救重组腺病毒的方法，该方法包括
a.提供适合拯救重组腺病毒的细胞，例如293细胞，
b.向所述细胞中引入本发明的环状DNA分子，其包含重组腺病毒基因组，其具有两个位于基因组末端侧翼的反向末端重复序列(ITR)，其中至少一个ITR与相邻于PAM序列的靶序列相关，其中每个靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，
c.在细胞内提供RNA引导的DNA核酸内切酶和至少一种gRNA，所述gRNA用于将RNA引导的DNA核酸内切酶靶向环状DNA分子的靶序列，
d.将细胞内包含两个ITR的重组腺病毒基因组线性化，
e.从细胞上清液中收集病毒颗粒。
本发明的具体实施例在以下示例中公开。这些包括质粒pO6-A5-mChe-WH、弹头(warhead)修饰的物种C BACs pBWH-C5-mChe、pBWH-C5-mChe-Cas9、pBWH-L-C5-mChe、pBWH-R-C5-mChe和pBWH-C5-gRNA-mChe、物种D BAC pBWH-D64M-GFP、物种E BACs pBWH-E04和pBHW-SE25、物种B质粒pLWH-B03和物种C质粒pAC05-CE1。
在本发明的具体实施例中，质粒pAR-gRNA-Cas9-Amp、pAR-gRNA-Ex、pAR-gRNA-IntC5、pAR-gRNA-IntD64、pSG5-Cas9、pBAd5-mChe、pBAd5-FG40-GFP和/或pBWH-C5-mChe-DD-Cas9可用于本发明方法的上下文中或可包含在本发明的试剂盒中。
本发明公开的质粒对应于以下序列：
Figure BDA0004152002130000081
Figure BDA0004152002130000091
关于用于构建本文公开的本发明的环状DNA分子和质粒的所公开的寡核苷酸(引物)、合成DNA片段和其他序列，特别是DNA序列SEQ ID NO.1-34和SEQ ID NO.58-64，以及根据SEQ ID NO.35-37的质粒，这些并不旨在限制本发明的范围，而是代表为更好地说明此处描述的本发明而提供的本发明各方面的优选实施例。本发明还涉及选自由以下组成的组的DNA序列：
-一个或多个序列，其包含相应序列SEQ ID NO.1-64的片段；
-一个或多个与根据a)的相应序列SEQ ID NO.1-64互补的核酸分子；
-一个或多个在严格条件下与根据a)或b)的核苷酸序列杂交的核酸序列；
-一个或多个核酸序列，其包含具有足够序列同一性以在功能上类似于根据a)、b)或c)的核苷酸序列的核苷酸序列；
-一个或多个核酸序列，其由于遗传密码，简化为根据a)至d)的核苷酸序列；和
-一个或多个根据a)至e)的核苷酸序列的核酸序列，其通过缺失、添加、取代、易位、倒位和/或插入进行修饰并且在功能上类似于根据a)至e)的核苷酸序列
因此，本发明包括与核酸序列SEQ ID NO.1-64具有至少60％、优选70％、更优选80％、尤其优选90％序列同一性的核酸序列。
本发明包含的所述特定核酸序列的序列变体，例如由所提供的％序列同一性定义、保持本发明的所述特性的序列变体也包括在本发明的范围内。此类变体显示替代序列，但保持与所提供的特定序列基本相同的特性，称为功能类似物或功能性类似物。序列同一性涉及在进行序列比对时相同核苷酸或氨基酸的百分比，例如使用诸如BLAST的软件。
应当理解，本发明的环状DNA分子的所有可能的优选特征也在本发明的试剂盒和方法的上下文中公开。反过来，在本发明的试剂盒或方法的上下文中公开的特征也涉及本发明的环状DNA分子。
具体实施方式
专利和非专利文献的所有引用文件均通过引用整体并入本文。
本发明涉及用于拯救重组腺病毒的环状DNA分子，包含重组腺病毒基因组，基因组末端侧翼有两个反向末端重复序列(ITR)，其中
-至少一个ITR与相邻于PAM序列的靶序列相关联，其中
-其中靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。
腺病毒是腺病毒科的成员，中等大小约为90–100nm。它们是无包膜(没有外部脂质双层)病毒，具有包含双链DNA基因组的二十面体核衣壳。它们有广泛的脊椎动物宿主；在人类中，已发现超过50种不同的腺病毒血清型可引起范围广泛的疾病，从幼儿的轻度呼吸道感染(称为普通感冒)到在免疫系统较弱的人中危及生命的多器官疾病。本发明涉及提供DNA分子以及用于拯救所有种类的重组腺病毒的方法和材料。然而，人和猿猴腺病毒是优选的。此外，本发明还涉及腺病毒载体的拯救，其来源于各种腺病毒，例如各种血清型的人或猿猴腺病毒。
腺病毒科的分类可能很复杂。在人类中，大约有7个物种的100种可接受的人类腺病毒类型(Human adenovirus A to G；according to the ICTV 9th Report(2011)available under:https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae；see also Lefkowitz etal.Nucleic Acids Res.2018Jan4；46(D1):D708-D717,doi:10.1093/nar/gkx932)。类型编号(1-57之间)与早期使用的血清型编号相同：A：12、18、31；B：3、7、11、14、16、21、34、35、50、55；C：1、2、5、6、57；D：8、9、10、13、15、17、19、20、22、23、24、25、26、27、28、29、30、32、33、36、37、38、39、42、43、44、45、46、47、48、49、51、53、54、56；E：4；F：40、41；G：52。对于无法通过血清学分类和新鉴定的类型的分离株，ICTV委员会按照接受的顺序给出了编号。本发明包括并适用于所有已知的腺病毒类型，并且可以预期它也适用于新鉴定的携带末端ITR的腺病毒类型。
不同的类型/血清型与不同的情况相关：呼吸道疾病主要是物种HAdV-B和C；HAdV-B和D常发生结膜炎；肠胃炎常与HAdV-F 40型、41型、HAdV-G 52型相关；肥胖或脂肪生成通常由HAdV-A 31型、HAdV-C 5型、HAdV-D 9、36、37型诱导。
本发明不限于感染人类的腺病毒(本文称为人类腺病毒或(如果指的是病毒基因组)人类腺病毒基因组)，还包括感染其他动物如猴子或黑猩猩的腺病毒。
具体包括猿猴乳腺病毒，尤其是猿猴乳腺病毒A、B和E，是感染猿猴的腺病毒。还包括最初从黑猩猩中分离出来的腺病毒，由于它们与某些人腺病毒(HAdV)非常相似，因此可以将其归类为“人”腺病毒种类。例如，猿猴腺病毒SAdV-22至SAdV-25属于人腺病毒E种(species human mastadenovirus E)，SAdV-21属于人乳腺病毒B种。
当不限于人类病毒时，腺病毒科可分为五个属：乳腺腺病毒属(Mastadenovirus)、禽类腺病毒属(Aviadenovirus)、富AT腺病毒属(Atadenovirus)、鸟类腺病毒属(Siadenovirus)和鱼类腺病毒属(Ichtadenovirus)，它们都可以是本发明的主题。
富AT腺病毒属包括牛中的牛腺病毒D，负鼠中的负鼠腺病毒A；绵羊中的绵羊腺病毒D；鹿中的鹿腺病毒A；鬃狮蜥、变色龙、壁虎中的蜥蜴腺病毒A；蛇中的蛇腺病毒A；鹦鹉中的鹦鹉腺病毒A；鸭中的鸭腺病毒A。鹅和家禽中的禽类腺病毒属禽类腺病毒A-E(禽流感病毒)；鹅中的鹅A型禽腺病毒；鸭中的鸭禽腺病毒B；鸽子中的鸽禽腺病毒A和B；猎鹰中的猎鹰腺病毒A；鹦鹉中的鹦鹉腺病毒B；火鸡中的火鸡腺病毒B至D。鱼类腺病毒属包括鲟鱼腺病毒A，也就是白鲟中的白鲟腺病毒。哺乳动物腺病毒属包括人中的人腺病毒AF(HAdV-A至HAdV-F)，有些也存在于猿猴中，例如黑猩猩；牛中的牛腺病毒A至C；犬腺病毒A；马中的马腺病毒A；绵羊中的绵羊腺腺病毒A和B；猪中的猪腺病毒A；猴子中的猿猴腺病毒A；树鼩中的树鼩腺病毒A；山羊中的“山羊腺病毒”(山羊腺病毒2，GAdV-2)；豚鼠中的“豚鼠腺病毒”；绵羊中的“绵羊腺病毒C”(绵羊腺病毒6，OAdV-6)。鸟类腺病毒属包括青蛙腺病毒A，也称为青蛙腺病毒1；大山雀中的大山雀腺病毒A；企鹅中的企鹅腺病毒；猛禽中的猛禽腺病毒A；贼鸥中的贼鸥腺病毒A；火鸡腺病毒A，也称为火鸡中的火鸡腺病毒A。
如示例中所示，本发明不限于人腺病毒，还适用于例如猿猴腺病毒，例如，并且没有理由相信它会限于腺病毒的特定属或种、类型或血清型。
腺病毒代表最大的已知无包膜病毒，可以通过核内体运输(即不需要包膜融合)。病毒体还有一个独特的“刺突”或纤维，与衣壳的每个五邻体碱基相关联，有助于通过宿主细胞表面的受体附着到宿主细胞上。
病毒体(病毒颗粒)包含的腺病毒基因组是线性的、非分段的双链(ds)DNA，通常介于26和48Kbp之间。这使得病毒理论上可以携带22到40个基因。病毒基因组具有与线性dsDNA的每个5'末端相关的末端55kDa蛋白质。这些在病毒复制中用作“引物”，并确保病毒线性基因组的末端得到充分复制。
如本文所用，应理解在包含重组腺病毒基因组的本发明环状DNA分子的上下文中，待包装到病毒颗粒中的重组腺病毒基因组的DNA序列由环状DNA分子包含。在本发明的上下文中，将包含重组腺病毒基因组序列的环状DNA分子引入生产细胞中。在其中，它通过RNA引导的核酸内切酶线性化，优选使用CRISPR/Cas系统，并且所得的包含重组腺病毒基因组序列或由重组腺病毒基因组序列组成的线性DNA分子可以复制并包装到细胞产生的病毒颗粒中。
腺病毒具有线性dsDNA基因组，它使用宿主的复制机制在脊椎动物细胞的细胞核中复制。进入宿主细胞是由纤维蛋白的旋钮结构域与细胞受体结合启动的，例如B组人腺病毒血清型的CD46和所有其他血清型的柯萨奇病毒腺病毒受体(CAR)。有一些报告表明MHC分子和唾液酸残基也具有这种能力。这种首次相互作用之后是二次相互作用，其中五邻体碱基蛋白(见壳粒)中的基序与αv整合素相互作用，作为共受体相互作用刺激腺病毒进入。与αv整合素结合导致病毒颗粒通过网格蛋白包被的凹坑被内吞。与αv整合素的结合会刺激细胞信号传导，从而诱导肌动蛋白聚合，导致病毒体进入核内体内的宿主细胞。
一旦病毒进入宿主细胞，核内体就会酸化，这会导致衣壳成分解散，从而改变病毒的拓扑结构。衣壳不稳定，蛋白质VI从衣壳中释放出来。这些变化以及五邻体的毒性会破坏核内体，导致病毒体移动到细胞质中。在细胞微管的帮助下，病毒被运送到核孔复合体，腺病毒颗粒由此分解。然后病毒DNA被释放并可以进入细胞核。在此之后，DNA与组蛋白分子结合，可以发生病毒基因表达，并可以产生新的病毒颗粒。
腺病毒生命周期分为两个阶段：早期阶段和晚期阶段。在这两个阶段中，都会生成一个初级转录本，该转录本被交替剪接以生成与宿主核糖体相容的单顺反子mRNA，从而允许翻译产物。早期基因主要负责表达非结构性调节蛋白。这些蛋白质的目标有三个：改变DNA合成所必需的宿主蛋白质的表达；激活其他病毒基因(如病毒编码的DNA聚合酶)；并避免受感染细胞因宿主免疫防御而过早死亡(细胞凋亡的阻断、干扰素活性的阻断以及MHC I类易位和表达的阻断)。DNA复制将早期和晚期分开。一旦早期基因释放出足够的病毒蛋白、复制机制和复制底物，腺病毒基因组的复制就会发生。与腺病毒基因组5’端共价结合的末端蛋白充当复制的引物。然后，病毒DNA聚合酶使用链置换机制来复制基因组，这与哺乳动物DNA复制中使用的传统冈崎片段相反。腺病毒生命周期的后期专注于产生足够数量的结构蛋白来包装DNA复制产生的所有遗传物质。一旦病毒组分成功复制，病毒就会组装到其蛋白质外壳中，并由于病毒诱导的细胞裂解而从细胞中释放出来。
腺病毒(Ad)作为一种有效的基因传递载体受到了极大的关注，并且实际上是第一个进入严格治疗开发的DNA病毒，因为它具有明确的生物学特性、遗传稳定性、高基因转导效率和易于规模化生产。Ad血清型在趋向性方面不同，并进一步分为六个亚组A–G。病毒衣壳的差异描述了血清型之间的向性。病毒衣壳由衣壳蛋白、核心蛋白和水泥蛋白组成。这些不同的血清型可以产生范围广泛的治疗候选病毒。
腺病毒载体具有重要优势：首先，腺病毒是体内递送基因的最有效方式，因为大多数人类细胞表达初级腺病毒受体和次级整合素受体。因此，很容易被腺病毒载体感染，从而产生高水平的转基因表达。其次，“无病毒基因的”腺病毒载体的发展使我们能够规避抗腺病毒载体免疫。第三，腺病毒载体在许多不同的临床应用中有着丰富的经验，最安全的给药剂量和给药途径也已确立。第四，腺病毒载体为开发修饰病毒衣壳的策略提供了一个通用型平台，以增强治疗特性并提高病毒的靶向特异性。有趣的是，腺病毒的一些遗传缺陷，例如针对腺病毒衣壳的免疫力和腺病毒基因的低水平表达，现在可能被证明有利于抗癌免疫疗法的发展，即诱导抗癌免疫或直接杀死癌细胞是目标。此外，针对腺病毒的联合免疫以及较短的表达时间非常适合使用腺病毒作为开发疫苗的平台。然而，根据应用，使用稀有血清型2和5构建用于基因治疗的腺病毒载体可能有利于避免预先存在的免疫力。
腺病毒载体可以转导复制的细胞群和静止期细胞群，使其成为在体内和成熟组织内传递转基因的重要工具。与慢病毒载体相比，腺病毒载体可以传递更大的转基因，大小最大可达8kbp；然而，它们的DNA并没有整合到宿主基因组中，而是以游离形式存在于宿主细胞核中。这种游离型转导排除了插入诱变的风险，无需直接整合到宿主基因组中。
腺病毒基因组是线性的、不分段的双链DNA，大小为长度从26kb到45kb不等，具体取决于血清型。常用的人腺病毒5型(HAdV-5)的基因组约为36kb。基因组DNA或基因组序列的两侧在两端上是发夹状反向末端重复序列(ITR)，可用于多种用途。ITR的作用之一是作为自引物促进不依赖引物酶的DNA合成，使其成为DNA增殖的重要元件。ITR的另一个功能是促进整合到宿主基因组中。除了ITR之外，腺病毒的另一个遗传元件是包装信号，它位于基因组的左臂，是正确的病毒转录包装所必需的。病毒转录本分为早期或晚期。四个早期转录单位E1、E2、E3和E4负责表达具有调节功能的非结构蛋白，尤其是在病毒DNA复制中。晚期蛋白质编码Ad病毒体的结构成分。
为了建立腺病毒载体使用的安全性，消除了必需的病毒复制基因。第一代腺病毒载体是那些去除了调控基因E1a和E1b的载体——E1a和E1b是病毒生命周期中产生的第一个转录调控因子。该基因的耗尽导致复制缺陷型腺病毒载体，其初始转基因克隆能力为5.2kb。
为了增加克隆能力并继续降低病毒复制能力，第二代腺病毒载体是通过删除其他非结构基因(E2/E3/E4)以及第一代载体中不存在的原始E1基因而开发的。虽然第二代载体表现出更高的克隆能力和更低的细胞毒性，但它们仍会触发体内免疫反应，导致转导细胞的产量降低。
为了开发免疫原性较低的载体，开发了第三代腺病毒载体。这些也称为高容量腺病毒载体(HC-AdV)，也称为无病毒基因的AdV或辅助依赖性AdV(HD-AdV)。HC-AdV去除了所有病毒编码序列，导致载体除了包装信号外仅具有5’和3’ITR，从而为转基因克隆序列(36kb)提供了更大的容量。此外，HC-AdV的结构最大限度地降低了细胞毒性，从而能够延长治疗基因的表达，使HC-AdV成为迄今为止最有希望用于基因治疗的AdV。HC-AdV是有益的，因为其缺乏可引起宿主免疫反应的病毒成分。HC-AdV被认为是“辅助依赖性的”，因为虽然这些载体缺乏病毒遗传成分，但它们也缺乏必要的包装成分。互补病毒或辅助病毒(HV)可用于提供必要的反式蛋白质，用于包装基于Ad的载体。HV没有与所需的HC-AdV一起包装，因为它的包装序列侧翼是loxP识别位点，其被Cre重组酶充分切除，因此辅助病毒DNA保持未包装状态。虽然HV的包装能力受到阻碍，但HV以正常水平复制，因此可以反式表达复制和包装包含适当顺式作用元件的载体基因组所需的所有功能。
Lee等人(Genes Dis.2017Jun；4(2):43–63.doi:10.1016/j.gendis.2017.04.001)详细描述了重组腺病毒载体的生成和所需重组腺病毒基因组的生成和所需的技术是本领域技术人员已知的。此类腺病毒基因组的产生也从以下示例的描述中显而易见。
至少已经开发了四种常用的方法来生成和生产用于基因递送的腺病毒载体，这些方法都需要重组腺病毒基因组的线性化。第一种传统方法使用HEK-293细胞中的重组。感兴趣的基因(GOI)首先被克隆到一个穿梭载体中，该穿梭载体包含5’-ITR、包装信号和腺病毒基因组的同源区域。腺病毒是在HEK-293细胞中通过穿梭载体(在转染到生产细胞之前必须线性化)和腺病毒骨架载体(其本身不能产生病毒)之间的重组而产生的。第二种方法使用Cre/LoxP介导的重组。GOI被克隆到包含LoxP(多个)位点的穿梭载体中。Cre重组酶介导的重组发生在体外含有LoxP的腺病毒骨架载体或293-Cre细胞中，导致腺病毒的产生。第三种方法使用AdEasy系统。GOI被亚克隆到一个穿梭载体中，该穿梭载体包含5’-ITR和包装信号，以及一个侧翼带有同源臂的含卡那霉素的细菌复制单元。重组腺病毒质粒是通过在卡那霉素选择下的细菌菌株BJ5183细胞中线性化穿梭载体和氨苄青霉素抗性腺病毒骨架载体(例如pAdEasy1)之间的同源重组产生的。将所得腺病毒质粒线性化并用于在HEK-293细胞中生产腺病毒。第四种方法使用辅助腺病毒来生产HC-AdV(或HD-AdV，或无病毒基因的AdV)。GOI被克隆到仅包含ITR和包装信号的转移载体中。腺病毒是用辅助腺病毒产生的，由于修饰后的HEK-293细胞中包装信号缺失，辅助腺病毒不会被包装，通常通过Cre/LoxP或FLP/FRT切除系统。
术语“重组”腺病毒基因组是指本发明的环状DNA分子所包含的腺病毒基因组的基因组DNA序列是通过遗传重组的实验室方法(例如分子克隆)形成或组装的，以汇集来自多个来源的遗传物质，创建无法以其他方式找到的序列。此外，在腺病毒基因组的上下文中，应理解，该术语还指由被一种以上病毒株感染的细胞中的病毒基因组之间的重组产生的病毒基因组，这可以通过不同病毒株的基因组核酸链的同源重组发生。
关于术语“适用于拯救重组腺病毒的细胞”，应理解，其涉及已被发现为可用于递送重组腺病毒基因组和用于产生重组腺病毒颗粒的可能的其他成分之后产生病毒颗粒的细胞或细胞系。因此，此类细胞也称为生产细胞/细胞系或生产性细胞/细胞系。
如本文所解释和技术人员所知，腺病毒载体(也称为腺病毒颗粒)，特别是HAdV-5的那些，对于广泛的基因治疗、疫苗和病毒治疗应用具有高度吸引力。野生型HAdV-5病毒可以在多种组织类型中复制。然而，为了将Ad载体用于治疗目的，病毒基因组需要修饰，如本文所述和本领域已知。如果以干扰病毒生命周期的方式修改病毒基因组，则需要特定的生产细胞系提供反式互补以克服修饰并允许病毒生产。根据腺病毒载体的类型和重组病毒基因组，技术人员可以选择合适的细胞系来生产腺病毒颗粒。
可以通过两种方式提供反式互补；使用含有并入细胞基因组的特定腺病毒序列以进行反式互补的生产细胞系，或使用与修饰的Ad载体基因组天然互补的生产细胞系。合适的细胞系是本领域已知的并且可以由技术人员鉴定，例如基于诸如Kovesdi等人(Viruses.2010Aug；2(8):1681–1703.doi:10.3390/v2081681)的综述文章。在下面的示例中公开了用于本发明上下文中的合适的细胞系。
例如，当基因组的E1区域被表达盒取代以产生可用于治疗的基因产物(如自杀基因、抗原和抗体)时，需要含有腺病毒E1序列的生产细胞系来补充这个区域。相比之下，编码抵消宿主防御机制的产物的E3区域是可有可无的，对于病毒体外复制不是必需的，因此没有必要反式补充E3。为了反式补充E1的缺失，历史悠久的细胞系是HEK293。人胚肾(HEK)293细胞系是在30多年前通过将E1A和E1B序列(从核苷酸(nt)1到4344)插入19号染色体19q13.2开发的。另一种生产性细胞系(也称为生产细胞系)是通过质粒转染将Ad5 nt 79–5789掺入人胚胎成视网膜细胞(HER)细胞的基因组而生成的911细胞系。911细胞系被确定在斑块形成和产量获得方面优于HEK293，因此成为另一个受欢迎的细胞系。A549细胞系是一种肺癌细胞系，已被发现适用于腺病毒生产，最显著是复制腺病毒构建体不需要病毒致癌基因早期区域1A(E1A)的互补，该区域负责病毒基因转录。该细胞系进一步用作测量缺乏E1A的腺病毒的复制检测中的阴性对照，并作为靶细胞系检测具有复制能力的腺病毒(RCA)。
本发明的一大优势在于，包含重组腺病毒基因组的环状dsDNA分子的线性化不必在dsDNA转染到生产细胞之前发生，但它可以通过CRISPR/Cas系统产生双链断裂的裂解/生成在生产细胞内发生。细胞内的线性化是非常有利的，因为这样可以转染环状DNA，这比线性化DNA的转染更容易和更有效。此外，线性化步骤通过CRISPR/Cas技术在细胞内自动发生。如本文所用，“线性化”是指在环状DNA分子中诱导至少一个双链断裂。在实施例中，可以在环状DNA分子中产生多于一个DSB，从而产生包含重组腺病毒基因组的线性DNA分子。当环状dsDNA分子中重组腺病毒基因组的两个ITR与相邻于PAM序列的靶序列相关时，情况尤其如此，该PAM序列配置为在两个ITR中的每一个的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。
包含重组腺病毒基因组的本发明的环状DNA分子可以是任何合适种类的环状DNA分子，例如优选细菌人工染色体(BAC)或质粒，优选高拷贝质粒。
腺病毒载体可能具有较大的基因组(即36kb)，这使得通过经典克隆策略进行的遗传操作变得困难且无效。然而，有使用受益于BAC的大克隆能力的BAC的病毒克隆技术。细菌人工染色体(BAC)是一种DNA构建体，基于功能性生育质粒(或F质粒)，用于在细菌(通常是大肠杆菌)中进行转化和克隆。F质粒起着至关重要的作用，因为它们含有分区基因(partition gene)，可促进细菌细胞分裂后质粒的均匀分布。细菌人工染色体的通常插入片段大小为150–350kbp。也已从P1噬菌体的DNA中产生了称为PAC的类似克隆载体，也可用于本发明的实施例中。
质粒是环状DNA分子。在细胞内，质粒与染色体DNA物理分离，可以独立复制。它们最常见于细菌中的小环状双链DNA分子；然而，质粒有时存在于古细菌和真核生物中。在自然界中，质粒通常携带有利于生物体生存的基因，并赋予诸如抗生素抗性等选择性优势。虽然染色体很大并且包含在正常条件下生活的所有基本遗传信息，但质粒通常相对较小并且仅包含在某些情况或条件下可能有用的额外基因。
如本文所用，本发明的环状DNA分子可以认为是人工质粒。人工质粒通常被广泛用作分子克隆中的载体，用于驱动重组DNA序列在宿主生物体内的复制。在实验室中，可以通过转化将质粒引入细胞。为了使质粒在细胞内独立复制，它们必须拥有一段可以作为复制起点的DNA。自我复制单位，在这种情况下，质粒，被称为复制子。一个典型的细菌复制子可能由许多元件组成，例如质粒特异性复制起始蛋白(Rep)的基因、称为迭代子的重复单元、DnaA盒和相邻的富含AT的区域。较小的质粒利用宿主复制酶制作自身的多个拷贝，而较大的质粒可能携带这些质粒复制的特异性基因。少数类型的质粒也可以插入宿主染色体，这些整合质粒在原核生物中有时被称为附加体。人工构建的质粒可用作基因工程中的载体。这些质粒是遗传学和生物技术中的重要工具，通常用于克隆和扩增(制作多个拷贝)或表达特定基因。多种质粒可商购用于此类用途，并且已经描述了用于克隆重组腺病毒基因组和用于从生产细胞中拯救腺病毒载体的方法的多种质粒和环状DNA分子。
如本文所用，在生产细胞系中产生、优选收集和任选地分离/纯化重组腺病毒颗粒的过程称为“重组腺病毒的拯救”。这涉及将环状DNA引入合适的生产细胞系，通过在一个(最好是两个)ITR外部或紧邻外部切割RNA引导的核酸内切酶来线性化环状DNA，以及随后收集来自生产细胞的上清液的病毒颗粒。从细胞培养物中收集病毒颗粒是常规程序，包括收集细胞上清液，并优选将细胞与含有病毒颗粒的液体分离，例如通过过滤或离心。病毒颗粒可以通过本领域已知的常规技术进行定量并且可以例如通过超速离心进一步浓缩。
CRISPR是Clustered Regularly Interspaced Short Palindromic Repeats(成簇的规律间隔的短回文重复序列)的缩写，是细菌中的DNA序列家族。这些序列包含来自攻击细菌的病毒的DNA片段。细菌使用这些片段来检测和破坏DNA，使其免受类似病毒的进一步攻击。这些序列在细菌防御系统中发挥着关键作用，并构成了称为CRISPR/Cas的技术的基础，该技术可有效且特异性地改变生物体内的基因。
CRISPR基因座的序列被转录并加工成CRISPR RNA(crRNA)，其与反式激活crRNA(tracrRNA)一起与CRISPR相关(Cas)蛋白复合，以通过核酸之间的Watson-Crick碱基配对指示Cas核酸酶对DNA切割的特异性(Wiedenheft,B et al(2012).Nature 482:331–338；Horvath,P et al(2010).Science 327:167–170；Fineran,PC et a.(2012).Virology434:202–209)。
结果表明，II型CRISPR核酸酶系统所需的三个成分是Cas9蛋白、成熟的crRNA和tracrRNA，通过将crRNA和tracrRNA融合成单个向导RNA(sgRNA)，可以将其减少为两个成分，将Cas9/sgRNA复合物重新定位到新位点可以通过改变一小部分gRNA的序列来实现(Garneau,JE et al(2010).Nature 468:67–71；Deltcheva,E et al.(2011).Nature 471:602–607,Jinek,M et al(2012)Science 337:816–821)。
CRISPR-Cas系统是细菌和古细菌的RNA引导的适应性免疫系统，可提供针对病毒或其他入侵遗传物质的序列特异性抵抗力。根据负责目标识别和入侵核酸切割的效应子模块的结构，这种免疫样反应被分为两类(Makarova KS et al.Nat RevMicrobiol.2015Nov；13(11):722-36.)。第1类包含多亚基Cas蛋白效应子，第2类由单个大效应蛋白组成。1类和2类都使用CRISP RRNA(crRNA)将Cas核酸酶成分引导至其靶位点，在那里它会切割入侵的核酸。由于其简单性，2类CRISPR-Cas系统在基因组编辑方面研究最多且应用最广泛。使用最广泛的CRISPR-Cas系统是CRISPR-Cas9。
事实证明，CRISPR/Cas9系统可以设计用于修饰细胞内的双链DNA分子，例如哺乳动物细胞中的高效遗传。CRISPR/Cas系统的唯一序列限制似乎源于紧邻靶序列3’的原型间隔子相邻基序(PAM)的必要性。PAM序列特定于Cas9的种类。例如，PAM序列5’-NGG-3’是化脓性链球菌中常用的Cas9结合和切割DNA所必需的。然而，具有新型PAM的Cas9变体已经并且可能通过定向进化进行设计，从而显著扩大了潜在靶序列的数量。与crRNA和tracrRNA复合的Cas9发生构象变化，并与整个基因组中的PAM基序相关联，直接询问上游序列以确定与gRNA的序列互补性。在匹配的靶位点形成DNA-RNA异源双链体，允许Cas9-RNA复合物切割目标DNA。这些方法和机制在本领域中是众所周知的。
如本领域所知，CRISPR/Cas9已被用于开发用于在动物、植物和微生物中进行基因组操作的有效工具，但如本文所示，还可以用于操作已引入宿主细胞的外源DNA分子。RNA引导的Cas9核酸内切酶首先识别一个2到4个碱基对的保守序列，称为原型间隔子相邻基序(PAM)，它位于目标DNA位点的侧翼。与PAM结合后，Cas9会询问侧翼DNA序列以与向导RNA进行碱基配对互补。如果向导RNA的前12个碱基对((“种子”序列)与目标DNA链之间存在互补性，则RNA链入侵会伴随局部DNA解旋形成R环。Cas9的RuvC和HNH结构域对每条DNA链的精确切割会在原型间隔序列3’边缘上游三个碱基对的位置产生钝双链DNA(dsDNA)断裂(DSB)，通过PAM测量。
Cas9作为优选的RNA引导的DNA内切核酸酶的这种DSB诱导活性被本发明用于在引入包含合适的gRNA和Cas9的生产细胞后在本发明的环状DNA分子中产生DSB。
CRISPR/Cas9基因组编辑实验一直在利用宿主细胞机制在Cas9生成的DSB位点精确修复基因组。突变可以通过DSB的非同源末端连接(NHEJ)或同源定向修复(HDR)产生。NHEJ可以在切割位点产生小的插入或缺失(INDEL)，而HDR使用天然(或工程)DNA模板通过重组用替代序列替换目标等位基因。其他DNA修复途径，如单链退火、替代末端连接、微观同源介导的连接、错配以及碱基和核苷酸切除修复，也可以产生基因组编辑。
已生成衍生自化脓性链球菌Cas9(SpCas9)的Cas9变体，用作切口酶、双重切口酶或FokI融合变体。最近，Cas9直系同源物和源自2类CRISPR-Cas系统(包括Cpf1和C2c1)的其他核酸酶已添加到CRISPR工具箱中。这些正在进行的挖掘丰富的细菌和古细菌CRISPR-Cas系统的努力应该会增加研究人员可用的分子工具的范围。
在本发明的上下文中，术语“RNA引导的DNA核酸内切酶”是指与至少一种RNA分子相互作用的DNA核酸内切酶。在本发明的上下文中，术语RNA引导的DNA核酸内切酶和RNA引导的核酸内切酶可互换使用。DNA核酸内切酶是切割DNA多核苷酸链中磷酸二酯键的酶。在RNA引导的DNA核酸内切酶的情况下，相互作用的RNA分子可以将RNA引导的DNA核酸内切酶引导至核酸内切酶变得活跃的DNA位点或位置。具体而言，术语RNA引导的DNA核酸内切酶是指天然存在或基因修饰的Cas核酸酶成分或CRISPR-Cas系统，包括但不限于1类CRISPR-Cas系统的多亚基Cas蛋白效应子以及2类系统的单个大效应Cas蛋白。
CRISPR/Cas系统和合适的RNA引导的核酸内切酶的技术应用的细节是技术人员已知的并且已经在文献中详细描述，例如Barrangou R等人(Nat Biotechnol.2016Sep8；34(9):933-941)、Maeder ML等人(Mol Ther.2016Mar；24(3):430-46)和Cebrian-Serrano A等人(Mamm Genome.2017；28(7):247–261)。本发明不限于使用特定的RNA引导的核酸内切酶，因此包括适用于本文描述的方法的在本发明的意义上任何给定的RNA引导的核酸内切酶的使用。
根据本发明，可以使用本领域已知的任何RNA引导的DNA核酸内切酶。RNA引导的DNA核酸内切酶包括但不限于1类CRISPR-Cas系统的Cas蛋白，例如Cas3、Cas8a、Cas5、Cas8b、Cas8c、Cas10d、Cse1、Cse2、Csy1、Csy2、Csy3、GSU0054、Cas10、Csm2、Cmr5、Csx11、Csx10和Csf1；2类CRISPR-Cas系统的Cas蛋白，例如Cas9、Csn2、Cas4、Cpf1、C2c1、C2c3和C2c2；来自各种细菌和古细菌物种的相应直系同源酶/CRISPR效应子；工程化的CRISPR效应子，具有例如新的PAM特异性、更高的精确性，例如SpCas9-HF1/eSpCas9，或改变的功能，例如切口酶。本发明特别优选的RNA引导的DNA核酸内切酶是化脓性链球菌Cas9(SpCas9)、金黄色葡萄球菌Cas9、嗜热链球菌Cas9、脑膜炎奈瑟菌Cas9(NmCas9)、新凶手弗朗西丝菌Cas9(FnCas9)、空肠弯曲菌Cas9(CjCas9)、Cas12a(Cpf1)和Cas13a(C2C2)(Makarova KS et al.(November 2015).Nature Reviews Microbiology.13(11):722–36)。
本文提供的定义和解释主要集中在SpCas9 Crispr/Cas系统上。然而，本领域技术人员知道如何使用替代的Crispr/Cas系统以及提供或允许获得关于此类替代系统的细节的信息的工具和方法。
在实施例中，本发明的DNA分子可以配置为用于由不同于Cas9或SpCas9的RNA引导的核酸内切酶例如Cpf1介导的DSB的产生。Cpf1需要一个相关的向导RNA来产生交错/粘性末端切割，并且它会切割非分裂细胞，例如神经细胞。
RNA引导的DNA核酸内切酶，特别是Cas9也可以是修饰的蛋白质，其中蛋白质的核酸酶功能被改变成切口核酸内切酶功能，其仅切割dsDNA的两条DNA链之一。换句话说，天然存在的核酸内切酶切割双链靶DNA的两条链的功能被改变成仅切割(即切口)其中一条链的核酸内切酶。这种修饰的RNA引导的DNA核酸内切酶在本发明的上下文中也称为“切口酶”。相应地修饰RNA引导的DNA核酸内切酶如Cas9的手段和方法在本领域是众所周知的，并且包括例如将氨基酸置换引入Cas9中，这使得核酸酶结构域之一失活。更具体地说，天冬氨酸盐可以被化脓性链球菌Cas9位置10的丙氨酸取代(SpCas9 D10A；Cong et al.(2013)Science339:819-823)。进一步的例子是本领域已知的，例如SpCas9中的H840A替代(Mali P etal.Nat Biotechnol.2013Sep；31(9):833-8；Ran FA et al.Cell.2013Sep 12；154(6):1380-9)。
根据本发明的方法，RNA引导的DNA内切核酸酶可以作为蛋白质引入，但可选地，RNA引导的DNA内切核酸酶也可以编码所述蛋白质的核酸分子的形式引入。应当理解，核酸分子以可表达形式编码所述RNA引导的DNA内切核酸酶，使得在细胞中的表达产生功能性RNA引导的DNA内切核酸酶蛋白，例如Cas9蛋白。确保功能性多肽表达的手段和方法是本领域众所周知的。
例如，核酸内切酶的编码序列可以包含在载体中，例如质粒、粘粒、病毒、噬菌体或常规用于例如基因工程的另一种载体。插入载体中的编码序列可以例如通过标准方法合成或从天然来源分离。编码序列可以进一步连接到转录调控元件和/或其他氨基酸编码序列。此类调控序列是本领域技术人员众所周知的，并且包括但不限于确保转录起始的调控序列、内部核糖体进入位点(IRES)和任选的确保转录终止和转录物稳定的调控元件。确保转录起始的调节元件的非限制性实例包括翻译起始密码子、转录增强子例如SV40增强子、绝缘子和/或启动子例如巨细胞病毒(CMV)启动子、SV40启动子、RSV-启动子(劳氏肉瘤病毒)、lacZ启动子、鸡β-肌动蛋白启动子、CAG-启动子(鸡β-肌动蛋白启动子和巨细胞病毒立即早期增强子的组合)、gai10启动子、人延伸因子1a-启动子、A0X1启动子、GAL1启动子、CaM激酶启动子、Iac、trp或tac启动子、IacUV5启动子、苜蓿银纹夜蛾多核型多角体病毒(AcMNPV)多角体启动子或哺乳动物和其他动物细胞中的珠蛋白内含子。确保转录终止的调控元件的非限制性实例包括V40-poly-A位点、tk-poly-A位点或SV40、lacZ或AcMNPV多面体多聚腺苷酸化信号，它们将包含在本发明的核酸序列下游。额外的调控元件可能包括翻译增强子、Kozak序列和侧翼为RNA剪接的供体和受体位点的间插序列。此外，还可以包括诸如复制起点、耐药基因或调节因子(作为诱导型启动子的一部分)的元件。
编码所述RNA引导的DNA核酸内切酶的核酸分子包括DNA，例如cDNA或基因组DNA，以及RNA，特别是mRNA。技术人员将容易理解，由于遗传密码的简并性，超过一个核酸分子可以编码根据本发明的RNA引导的DNA核酸内切酶。简并性的结果是因为三联体密码指定了20个氨基酸和一个终止密码子。因为存在四个用于编码遗传信息的碱基，所以需要三联体密码子来产生至少21种不同的代码。三联体中碱基的可能e可能性给出了64个可能的密码子，这意味着一定存在一些简并性。结果，一些氨基酸由不止一个三联体编码，即最多达六个。简并性主要是由三联体中第三个位置的改变引起的。这意味着可以根据本发明使用具有不同序列但仍编码相同RNA引导的DNA核酸内切酶的核酸分子。
根据本发明使用的核酸分子可以是天然的以及(半)合成来源的。因此，核酸分子例如可以是根据有机化学的常规方案合成的核酸分子。本领域技术人员熟悉所述探针的制备和使用(参见，例如，Sambrook and Russel"Molecular Cloning,ALaboratory Manual",Cold Spring Harbor Laboratory,N.Y.(2001))。
本发明涉及环状dsDNA分子的双链断裂的产生。其中，本发明的环状DNA分子包含至少一个、优选两个靶序列，其与ITR相关联并且由与RNA引导的DNA核酸内切酶相关联的至少一种向导RNA靶向。
根据本发明，“靶序列”是dsDNA分子中的核苷酸序列，由于向导RNA包含的靶特异性序列，它被与RNA引导的核酸内切酶相关联的至少一种向导RNA识别。靶序列至少部分与向导RNA的目标特定序列互补，并与所谓的原型间隔区相邻基序(PAM)相关联。PAM是一个2-6个碱基对的DNA序列，相邻靶序列定位，可以位于靶序列的5’端(例如Crispr/Cpf1系统)或3’端(例如Crispr/Cas9系统)，取决于所使用的Crispr/Cas系统。如果识别的靶序列与PAM序列不相关，则RNA引导的核酸内切酶(例如Cas9或Cpf1)将无法成功结合并切割目标dsDNA分子。在靶序列和向导RNA的目标特定序列之间形成DNA-RNA异源双链体，允许通过向导RNA/RNA引导的核酸内切酶复合物切割目标DNA。靶向dsDNA分子的切割发生在靶序列内或与靶序列相邻的位点，具体取决于使用的RNA引导的核酸内切酶和CRISPR/Cas系统。
例如，在SpCas9的情况下，至少20个核苷酸的DNA靶序列直接位于不变的5’-NGG-3’PAM的上游/5’端。因此，在SpCas9用作RNA引导的核酸内切酶的情况下，可以理解，位于PAM附近的靶序列意味着靶序列直接从PAM序列上游开始，中间没有其他核苷酸。向导RNA与DNA靶序列的正确配对导致在靶序列内PAM上游3个碱基对(bp)的dsDNA分子中产生双链断裂(SpCas9对dsDNA分子的“切割”)。
然而，例如，如果使用CRISPR/Cpf1系统，Cpf1-crRNA复合物通过识别可能位于原型间隔子相邻基序(例如5’-YTN-3’(其中“Y”是嘧啶，“N”是任何核碱基)或5’-TTN-3’)的下游/3’端的靶序列来切割目标DNA。Cpf1可以引入粘性末端/交错末端DNA双链断裂。在AsCpf1和LbCpf1的情况下，可以产生带有4个核苷酸悬垂的双链断裂，它可以发生在目标(+)链PAM下游19bp和(-)链上PAM下游23bp处。
如以上实施例所示，双链断裂的确切位点取决于本发明方法中使用的Crispr/Cas系统或RNA引导的核酸内切酶，因此可以由本领域技术人员在选择RNA引导的核酸内切酶时确定。
在本发明的上下文中，靶序列也可称为“原型间隔子”。术语“靶位点”可以指包含靶序列和相关联的PAM的dsDNA分子中的位置或序列。
在本发明的上下文中，术语“双链断裂”或“DSB”是指dsDNA分子的两条链都被打断，导致位于双链断裂侧的上游和下游的dsDNA分子的部分分离。相反，单链断裂是指两条DNA链中只有一条断裂，不会导致位于双链断裂侧上游和下游的dsDNA分子部分分离。
在优选的实施例中，RNA引导的核酸内切酶产生平末端。在替代实施例中，RNA引导的核酸内切酶产生粘性末端。
在本发明的上下文中，双链断裂可由于两条链被一种RNA引导的核酸内切酶切割或由于切口酶对(+)和(-)链的两个单链切割而发生。
双链断裂可以通过在互补链上的相同/相应位置切割dsDNA的两条链而产生，导致dsDNA分子的所得分离末端形成平末端，因为它主要是Cas9介导切割的情况。然而，在非规范切割的情况下，Cas9也可能诱导形成具有粘性/交错末端的双链断裂，其中dsDNA的两条互补DNA链上的链断裂位于不同位置，导致形成裂解的dsDNA分子末端的链悬垂。
此外，某些RNA引导的核酸内切酶会规律产生粘性末端，例如Cpf1。也可以通过选择某些靶序列来影响RNA引导的核酸内切酶产生粘端或平端的趋势。
此外，通过靶向两条链上不同靶序列的各个切口酶在(+)和(-)链上诱导单链断裂，可以有意地产生特定配置的粘端双链断裂。通过使用这种方法，可以精确地选择单链断裂的位点。在不超过50个核苷酸的距离内在两条互补链上诱导两个单链断裂，优选不超过40nt、35nt、30nt或25，最优选不超过20、19、18、17、16、15、14、13、12、11、10、9、8、7、6、5、4、3、2或1nt，将导致dsDNA分子末端在相应单链断裂的远端和近端分离，导致形成具有相应长度的悬垂的粘性末端。通过使用这种诱导双链断裂的方法，可以精确地选择在dsDNA分子的分离末端产生什么样的悬垂。对于每个双链断裂，可能需要至少两个向导RNA分子。
应当理解，术语“表达盒”是指载体DNA的不同组分，其由编码序列(例如基因)和将由转染细胞表达的调控序列组成。在每次成功的转化中，表达盒都会指导细胞的机制来制造(表达)RNA并最终产生蛋白质，具体取决于表达盒的种类。有包含蛋白质表达调节序列的表达盒和特定于某些种类RNA表达的表达盒。一些表达盒设计用于RNA或蛋白质编码序列的模块化克隆，以便可以轻松地改变相同的表达盒以产生不同的RNA或蛋白质。例如，表达盒可以由一个或多个基因或编码序列和控制它们表达的序列组成。优选地，表达盒包含三个组分：启动子序列、开放阅读框、和3’非翻译区，其在真核生物中通常包含聚腺苷酸化位点。只要使用正确的调控序列，就可以将不同的表达盒转染到不同的生物体中，包括细菌、酵母、植物和哺乳动物细胞。
在本发明的实施例中，环状DNA分子包含一种或多种gRNA和/或Cas9的表达盒。此类表达盒位于腺病毒基因组序列外部的重组腺病毒基因组的两个ITR之间，即在环状DNA分子的主链中。此类实施例是其中重组腺病毒基因组包含在BAC中的优选实施例，因为BAC足够大以额外包含一个或两个或多个gRNA和/或Cas9或另一种合适的RNA引导的核酸内切酶的表达盒。
在本发明的实施例中，用于表达一种、两种或更多种gRNA和/或用于表达Cas9的表达盒存在于不同于包含重组腺病毒基因组的环状DNA分子的DNA分子中的生产细胞中。例如，这样的表达盒可以被引入不同的质粒或已经通过病毒载体被引入。表达盒可能已经整合到生产细胞的基因组中。合适的调节序列，例如用于介导gRNA和Cas9表达的启动子和/或增强子序列是本领域已知的，并且此类调节序列的具体实例在下文的示例部分中描述。
在实施例中，还可以通过RNA或蛋白质转染或本领域描述的其他方法将gRNA和Cas9引入细胞以提供CRISPR/Cas系统的这些组件。
本发明还涉及一种体外拯救重组腺病毒的方法，该方法包括
a.提供适合拯救重组腺病毒的细胞，例如293细胞，
b.向所述细胞中引入本发明的环状DNA分子，其包含重组腺病毒基因组，其具有两个位于基因组末端侧翼的反向末端重复序列
(ITR)，其中至少一个ITR与相邻于PAM序列的靶序列相关，其中每个靶序列配为置用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，
c.在细胞内提供RNA引导的DNA核酸内切酶和至少一种gRNA，
用于将RNA引导的DNA核酸内切酶靶向环状DNA分子的靶序列，
d.将细胞内包含两个ITR的重组腺病毒基因组线性化，
e.从细胞上清液中收集病毒颗粒。
如本文所用，术语“引入细胞中”涉及将蛋白质或核酸分子引入细胞中的任何已知方法。在细胞内提供蛋白质，例如RNA引导的DNA核酸内切酶、或核酸分子可以通过预先引入所述分子本身或通过引入能够表达所述分子的另一种分子来实现。将分子引入细胞的方法的非限制性实例包括显微注射、病毒载体感染、电穿孔、转染，例如使用具有阳离子脂质的制剂进行转染。将本发明的组分引入细胞的合适方法是本领域技术人员已知的。在实施例中，本发明的方法包括将编码RNA引导的DNA核酸内切酶和/或至少一种向导RNA的核酸分子引入生产细胞中。
如本文所用，“核酸”应指任何核酸分子，包括但不限于DNA、RNA及其杂交子或修饰变体。“外源核酸”或“外源遗传元件”涉及引入细胞中的任何核酸，其不是细胞“原始”或“天然”基因组的组分。外源核酸可以整合或不整合在靶细胞的遗传物质中，或与稳定转导的核酸有关。
根据本发明使用的核酸分子可以是本领域已知的核酸模拟分子，例如核酸分子的合成或半合成衍生物和混合聚合物。它们可以含有额外的非天然或衍生的核苷酸碱基，如本领域技术人员将容易理解的那样。根据本发明的核酸模拟分子或核酸衍生物包括但不限于硫代磷酸酯核酸、氨基磷酸酯核酸、吗啉代核酸、己糖醇核酸(HNA)、肽核酸(PNA)和锁核酸(LNA)。
此外，本发明的方法包括将至少一种向导RNA引入细胞。在本发明的上下文中，“向导RNA”是指与RNA引导的DNA核酸内切酶相互作用而导致识别将被RNA引导的DNA核酸内切酶切割的靶序列的RNA分子。根据本发明，术语“向导RNA”(或gRNA)因此包括但不限于靶序列特异性CRISPRRNA(crRNA)、反式激活crRNA(tracrRNA)和嵌合单向导RNA(sgRNA)。
crRNA因RNA引导的核酸内切酶和CRISPR/Cas系统而异，但通常包含长度为20至72个核苷酸的靶特异性序列，侧翼为两个长度为21至46个核苷酸的同向重复(DR)。在化脓性链球菌的情况下，DR长36个核苷酸，靶序列长30个核苷酸。crRNA位于3’的DR与相应的tracrRNA互补并杂交，后者又与Cas9蛋白结合。
如本文所用，术语“反式激活crRNA(tracrRNA)”是指小RNA，其与pre-crRNA(位于crRNA的3’的DR)互补并碱基配对，从而形成RNA双链体。然后，这种pre-crRNA被RNA特异性核糖核酸酶切割，形成crRNA/tracrRNA杂交体，随后作为核酸内切酶Cas9的向导，Cas9切割入侵的核酸。
如本文所述，编码CRISPR/Cas系统元件(例如Cas9、tracrRNA和crRNA)的基因通常组织在细菌基因组的操纵子中。DR序列与RNA引导的核酸内切酶(例如其他细菌物种的Cas9蛋白)一起发挥作用，可以通过以下鉴定：对出现在相应Crispr/Cas操纵子中的序列重复进行生物信息学分析，以及通过对Cas9蛋白和tracrRNA以及侧翼为假定的DR序列的靶序列的实验性结合研究。
优选地，可以使用包含这种靶序列特异性crRNA和tracrRNA的嵌合单向导RNA序列。这种嵌合(ch)RNA可以通过将20个或更多核苷酸(nt)的靶特异性序列与部分或整个DR序列(定义为crRNA的一部分)与全部或部分tracrRNA的融合来设计，如(Jinek etal.Science 337:816-821)所示。在嵌合RNA中，DR的一个片段和tracrRNA序列是互补的，能够杂交并形成发夹结构。
在实施例中，本发明的至少一种向导RNA也可以由引入细胞中的核酸分子编码。上述关于编码核酸内切酶的核酸分子的定义和优选实施例同样适用于编码这些RNA的核酸分子。用于表达RNA的调控元件是本领域技术人员已知的，例如U6启动子。
本公开内容还包括试剂盒、包装和多容器单元，其包含在本发明方法的上下文中使用的材料、分子和组分。
附图说明
通过以下附图进一步描述本发明。这些并非旨在限制本发明的范围，而是代表为更好地说明本文描述的本发明而提供的本发明方面的优选实施例。
附图简要说明：
图1：重组腺病毒基因组的DNA编码线性化策略的示意图。
图2：将CRISPR/Cas9介导的末端解析应用于腺病毒重建(CTR)的主要方法及其效率。
图3：使用CRISPR-Cas9介导的末端解析(CTR)方法的反向遗传系统的示意图。
图4：稳定转染pSG5-Cas9的不同293A-Cas9细胞克隆的Cas9蛋白相对表达水平。
图5：精确切割对重组HAdV-5和HAdV-4拯救效率的影响。
附图详细说明：
图1：A)腺病毒重建的传统方法是将携带rAd基因组的环状DNA线性化，并通过大肠杆菌中的细菌维持盒(bac)作为质粒或BAC维持。通过用限制性核酸内切酶处理纯化的DNA使构建体线性化，这些限制性内切酶专门识别病毒ITR(RE)旁边的位点。经过额外的纯化步骤后，线性化的DNA可以转染到适当的细胞中以产生复制病毒。B)本研究中测试的方法使用Cas9的靶向核酸内切酶活性，以促进体内的末端解析。因此，可以从大肠杆菌中提取质粒，直接导入到允许细胞中。C)为了允许体外终端解析，病毒ITR由CRISPR/Cas9靶序列(弹头；WH)和所需的PAM(灰色字母)扩展。弹头旨在靶向通用sgRNA(gRNA-Ex，下划线表示)，在来自ITR的Cas9 6-7bp存在的情况下诱导双链断裂。或者，相同的序列允许设计针对每种腺病毒类型特异的ITR的sgRNA(gRNA-Int)。这里以HAdV-C5的ITR序列为例。该sgRNA将在靠近基因组末端的Cas9存在的情况下引导双链断裂。显示的是序列SEQ ID NO.33(上)和相应的互补序列SEQ ID NO.34(下)代表桥接ITR外末端的区域中的DNA双链序列、引入的弹头序列和BAC的相邻序列。
图2：A)为末端解析提供CRISPR/Cas9组件的不同方式的示意图。i)表达sgRNA和Cas9蛋白的质粒与携带rAd基因组的构建体共转染的表示。ii)描绘了一种编码rAd基因组和所有CRISPR-Cas9组件的构建体。iii)Cas9通过用于拯救rAd的细胞系的组成型表达来递送，而编码rAd基因组的质粒与表达sgRNA的质粒一起共转染。iv)与iii)相同，但sgRNA由编码rAd基因组的相同构建体表达。B)作为灶/每转染微克基于HAdV-C5的rAd的DNA的重建效率，环状构建体pBWH-C5-mChe，在引入体外核酸内切酶(PacI)处理的rAd基因组后，携带彼此相邻的ITR的环状Ad基因组，以及将pBWH-C5-mChe和pAR-gRNA-Cas9-Amp共转染到293AC)或在体外用PacI或pBWH-D64-GFP与pAR-gRNA-Cas9-Amp一起处理pBAd19a-GF。D)用描述的构建体(pBW-C5-mChe-Cas9和pBWH-C5-mChe以及pAR-gRNA-Cas9-Amp)转染293A细胞后递送途径i和ii(在A中)的效率比较。E)当以指定浓度应用Shield-1时，将表达条件Cas9(DDD-Cas-9)的构建体(pBWH-C5-mChe-DD-Cas9)的重组效率与如上转染至293A后wt Cas9表达构建体(pBWH-C5-mChe-Cas9)进行比较。F)比较Cas9表达细胞系(途径iii和iv，如A中所示)中带弹头的rAd构建体(pAC05-CE-1或pBWH-C5-mChe)与应用于293A细胞中的基本方法(如A中的i所示)的重组效率。G)比较pBWH-C5-mChe和pBWH-D64-GFP分别与pSG5-Cas9和靶向弹头序列(gRNA-Ex)或ITR(分别是gRNA-IntC5或gRNA-IntD64)的sgRNA共转染的拯救效率。sgRNA-Ex的目标是与ITR相距6-7bp的双链断裂，而菌株特异性sgRNA-Ints的目标是双链断裂恰好位于ITR的5’端(参见图1C)。灶数量分别在转染后第4天或第7天确定。H)比较pBWH-C5-mChe和单个侧翼有ITR的构建体pBWH-L-C5-mChe和pBWH-R-C5-mChe的拯救效率，与靶向弹头序列(gRNA-Ex)的pAR-gRNA-Amp共转染293-Cas9细胞。在转染后第4天开始确定灶峰形成。
图3：从受感染的细胞中提取病毒DNA(深灰色，两侧为ITR的空心符号)，并使用两种不同的引物对通过PCR扩增细菌载体(浅灰色)。每对的外部引物侧翼是与相应的病毒ITR(空心符号)的同源性(40nt)，并且还包括弹头序列(黑条)。两个内部引物的侧翼彼此具有同源性(40nt)(灰色框)。病毒DNA和两个由此产生的PCR扩增子可以在Gibson组装(GA)反应中融合，使其为细菌转化做好准备。
图4：在G418选择下用pSG-Cas9稳定转染293A细胞后挑选单个克隆。在存在连续G418选择的情况下可以启动连续细胞系的所有克隆都描绘在x轴上。使用流式细胞术检测Cas9上的C末端Flag标签来确定Cas9表达水平。平均荧光强度(MFI)计算为与亲本293A细胞染色后恢复的信号相比的倍数变化。细胞克隆B2在所有三个独立实验中是具有最高表达水平的细胞系。在共转染环状pBWH-C5-mChe和pAR-gRNA后，还测试了所有克隆的重建HAdC5-mChe的能力。如果克隆在两个独立实验中支持rAd灶形成，则该克隆被认为是阳性的(允许性，灰色条)。不能重复支持rAd拯救的克隆被认为是非允许性(黑色条)。
图5：A)显示了pBWH-C5-mChe的新构建的ITR-杠粒边界之一，它可以被sgRNA-Ex(下链，PAM加下划线)靶向，诱导ITR外部6-7bp的双链断裂(仅由sgRNA靶向链上的黑色三角形表示)。另一种靶向ITR(粗体)的sgRNA(sgRNA-IntC5，上链，PAM带下划线)可以直接在ITR处诱导Cas9介导的切割。为了检查切割距离的影响，在ITR末端(参见下图，Ad5-18/19)和CRISPR/Cas9靶序列之间使用12bp长的间隔子延长了ITR，其被sgRNA-Ex靶向(下链，PAM带下划线)在ITR上游18-19bp处诱导双链断裂(黑色三角形)。显示的是序列SEQ ID NO.61(上)和相应的互补序列SEQ ID NO.62(下)代表桥接ITR外末端和BAC相邻序列的区域中的DNA双链序列。B)在存在sgRNA-IntC5(Ad5-Int5)或sgRNA-Ex(Ad5-Ex)的情况下，用PBWH-C5-mChe和Psg5-Cas9共转染293A细胞，或在存在sgRNA-Ex(Ad5-18/19-Ex)的情况下，用pBWH18/19-C5-mChe共转染293A细胞后，比较rAd重建效率。初级拯救效率如图2G所示获得。使用Welch ANOVA检验计算显著性。C)类似地，对于上述基于HAdV-5的构建体(上图)，构建了基于重组HAdV-4的杆粒，在其两个ITR处侧翼为弹头序列(PAM有下划线)(此处显示右侧ITR，白色字母)。该序列可以像基于HAdV-5的构造体一样被通用sgRNA-Ex靶向。这里还有另一个靶向HAdV-4ITR(粗体)的sgRNA(sgRNA-Int4，上链，PAM带下划线)可以直接在Ad4-ITR(灰色三角形)处诱导Cas9介导的切割。显示的是序列SEQ ID NO.63(上)和相应的互补序列SEQ ID NO.64(下)代表桥接右侧ITR外末端和BAC相邻序列的区域中的DNA双链序列。D)在用pBWH-E4-DE3与表达pAR-gRNA-Ex的sgRNA-Ex(E4-Ex)的Par-Grna-Ex或表达sgRNA-Int4的pAR-gRNA-Int4(E4-Int4)共转染293A细胞后确定rAd重组效率。如图2G所示获得初级拯救效率。使用非配对t检验计算显著性。
示例
通过以下实施例进一步描述本发明。这些并非旨在限制本发明的范围，而是代表为更好地说明此处描述的本发明而提供的本发明方面的优选实施例。
实施例的材料和方法
细胞、病毒、细菌
人胚肾细胞293A(Invitrogen，卡尔斯巴德，加利福尼亚州，美国)，它是293细胞系22的亚克隆，选择用于高效产生rAd，人肺腺癌细胞系A549(ATCC CCL-185)，HAdV-C5转化的人胚胎视网膜母细胞系91123(由苏黎世大学Urs Greber友情提供)和表达Cas9的A549-Cas9细胞系24在补充有胎牛血清(FCS 10％v/v，Sigma-Aldrich，圣路易斯，密苏里州，美国)和青霉素-链霉素(100U/ml，Gibco，卡尔斯巴德，加利福尼亚州，美国)的Dulbecco改良Eagle培养基(DMEM)中培养。此外，对于A549-Cas9，培养基中补充了1μg/ml杀稻瘟菌素(InvivoGen，圣地亚哥，加利福尼亚州，美国)。
为了生成稳定表达密码子优化的SpCas9(293A-Cas9-B2)的基于293A的细胞系，我们通过电穿孔将低传代293A细胞与NdeI线性化pSG5-Cas9(如下所述)和PvuI处理的pGC-neo25共转染，在310V和无限电阻下使用25.5ms方波方案，转染后2天，通过施用500μg/mlG418(Formedium，诺福克，英国)选择细胞。挑选单个克隆并通过流式细胞术分析Cas9表达，并通过共转染pBWH-C5-mChe和pAR-gRNA-Ex测试它们对rAd拯救的允许性(见下文)。其中一个克隆(B2)在两种测定中都表现良好，在本研究中被选择、扩增并用作腺病毒E1补充、表达Cas9的细胞系。
人腺病毒B型3(HAdV-B3)(原型株GB，ATCC VR-847，由汉诺威医学院ThomasAdrian友情提供)，人腺病毒E型4(HAdV-E4)(原型株RI-67，VR-1572)和猿猴腺病毒25型(SAdV-25，VR-594)获自ATCC。基于E1和E3缺失的人腺病毒C型5载体(Ad5-CMV/mCherry)的rAd载体，在hCMVie1启动子下表达报告基因mCherry，获自Sirion Biotech(普兰尼格，德国)。用于生成HAdV-B3和-E4初级结构以及用于Ad5-CMV/mCherry的rAd载体的病毒DNA如前所述26从感染细胞中收获。
大肠杆菌菌株NEB10beta(基因型：Δ(ara-leu)7697araD139 fhuAΔlacX74galK16galE15 e14-φ80dlacZΔM15 recA1 relA1 endA1 nupG rpsL(StrR)rph spoT1Δ(mrr-hsdRMS-mcrBC))和NEB5alpha(基因型：fhuA2Δ(argF-lacZ)U169 phoA glnV44Φ80Δ(lacZ)M15 gyrA96 recA1 relA1 endA1 thi-1hsdR17)购自德国法兰克福的新英格兰生物实验室。含有ori6Kγ质粒Pir-1的菌株(基因型：F-Δlac169 rpoS(Am)robA1creC510hsdR514 endA recA1 uidA(ΔMluI)::pir-116)购自Invitrogen(卡尔斯巴德，加利福尼亚州，美国)。
质粒
表1列出了用于质粒构建或BAC工程的寡核苷酸和合成DNA片段。表2和表3分别总结了本研究中产生的质粒和rAd构建体的基本特征，包括它们的登录号。
pO6-A5-mChe-WH的构建是为了通过将来自pmCherry-C1(Takara，草津市，日本)的Wh序列和mCherryORF引入pO6-A5-CMV-gfp，将sgRNA靶位点紧邻Ad5载体的左侧ITR(SirionBiotech，普兰尼格，德国)。类似地，pO6-A5-WH18/19-mChe是通过将相同的弹头(Wh)序列插入pO6-A5-CMV构建的，但在Wh序列和ITR之间具有12个碱基对的间隔子(CAAATTCCTTGG(SEQID NO.58))。表达盒DDD-Cas9是在pDD-Cas9(Addgene Plasmid#90086，来自SordellaRafella27的友情礼物)的基础上构建的，通过插入谷氨酰胺密码子而不是Cas9编码序列的第一个甲硫氨酸密码子，并且通过删除DD结构域在pDD-Cas9的基础上构建Cas9(wt)盒。通过将U6启动子(GenBank登录号JN255693.1)融合到包含低脱靶活性的gRNA靶向位点的sgRNA支架，合成了sgRNA表达盒，描述于Yuen et al.201728(来自IDT的gBlock，科拉尔维尔，爱荷华州，美国)。这种sgRNA构建体被称为sgRNA-Ex。pHg-RNA-DDD-iGFP和pH-gRNA-Cas9(wt)-iGFP是通过将sgRNA-Ex和野生型以及上述密码子优化版本的SpCas927表达盒插入载体pH-iGFP(GeneBank Acc 2324217)而构建。这些构建体用于将CRISPR/Cas组件插入到在其rox位点包含BAC的rAd基因组(见下文)。用于生成稳定表达Cas9的细胞系的pSG5-Cas9是通过将来自pH-gRNA-Cas9(wt)-Flag的Cas9 ORF插入pSG5表达载体(Agilent，圣克拉拉，加利福尼亚州，美国)构建的。高拷贝质粒pAR-gRNA-Cas9-Amp编码sgRNA-Ex和来自pH-gRNA-Cas9-Flag的Cas9(wt)表达盒是通过将各自的CRISPR/Cas组件插入pcDNA3.1的PCR扩增载体骨架构建的。单独编码sgRNA-Ex的pAR-gRNA-Ex是通过PCR扩增pAR-gRNA-Cas9-Amp的相应部分并重新连接EcoRI消化的扩增子构建的。通过将pAR-gRNA-Ex的外部靶向序列替换为相应的内部靶向序列(TATATTATTAGATAGCCTC(SEQ ID NO:59)，构建了编码精确切割HAdV-5ITRs(Int5)特异性sgRNA的pAR-gRNA-IntC5。通过将pAR-gRNA-Cas9-Amp的外部靶向序列替换为Int4的相应内部靶向序列(TATATTATATAGATAGCCTC(SEQ ID NO:60)，构建了编码用于精确切割HAdV-4和Cas9特异性sgRNA的pAR-gRNA-Int4。
通过将上述sgRNA-Ex序列、来自pKSB229的氯霉素抗性基因和rox位点插入Litmus28(New England Biolabs，法兰克福，德国)替换其氨苄青霉素抗性基因和MCS，构建质粒pAR-19，该质粒用作细菌载体骨架以将病毒基因组克隆到大肠杆菌中的高拷贝质粒。
基于已发布的Ad构建体编码重组腺病毒的质粒和BAC
细菌rAd构建体是通过修饰现有的rAd构建体产生的，以使它们与新的拯救技术兼容，通过在其ITR附近引入CRISPR-Cas靶位点(弹头)(在本章中描述)，或通过腺病毒基因组的从头克隆，使用Gibson组装成PCR扩增的高拷贝载体或BAC载体片段(在下一章中描述)。为了修饰基因组构建体，我们使用了基于重组工程或单步位点特异性重组3SR30。对于重组工程，我们使用基于辅助质粒pKD4631或pSC101-BAD-gab-tet(GeneBridges，柏林，德国)的方法，具体取决于要应用的选择标记。
为了使现有的rAd BAC适应CRISPR/Cas介导的体内末端解析，我们必须在Ad基因组末端附近引入sgRNA识别位点(弹头)。所得构建体称为pBWH-C5-mChe，代表分两步构建的基于HAdV-C5的第一代载体(ΔE1、ΔE3)。首先，我们通过Flp介导的单步位点特异性重组(Flp-3SR)30将pO6-A5-mChe-WH插入到pBA5-FRT3中。此插入将弹头序列传送到左侧ITR和mCherry表达盒附近。该构建体被命名为pBWH-L-C5-mChe。为了引入与右侧ITR相邻的第二个弹头序列，我们进行了两步重组工程31，同时允许i)在右侧ITR和E4启动子之间引入loxP位点，以便稍后插入第二个转录单元如Suzuki等人32所描述的这个载体，和ii)将rox位点33插入到BAC载体区域中，该区域于Dre介导的3SR(Dre-3SR)30的右侧ITR的侧翼。类似地，我们分两步构建了pBWH18/19-C5-mChe：首先通过对包含额外间隔序列的合成线性DNA片段进行重组工程来修饰右侧ITR，如图5A所示，然后通过3SR将pO6-A5-WH18/19-mChe插入pBA5-FRT-WH18/19。我们还以相同的方式修饰了pBA5-FRT生成构建体，仅在其右侧的ITR(pBWH-R-mChe)的侧翼是弹头序列。通过使用Dre-3SR将pH-gRNA插入pBWH-C5-mChe构建了在细菌载体骨架中携带sgRNA-Ex表达盒的构建体pBWH-C5-gRNA-mChe。通过Dre-3SR将pH-gRNA-Cas9(wt)-iGFP插入pBWH-C5-mChe构建仅在细菌载体骨架中携带Cas9核酸酶表达盒的pBWH-C5-Cas9。
构建体pBAd5-FG40-GFP类似于之前发布的pFG40构建体10。它是通过将pO6-A5-CMV-gfp(Sirion Biotech，普兰尼格，德国)的修饰版本插入到pBA5-FRT中构建的。该供体质粒携带来自pFG40的回文ITR序列而不是野生型IRT，从而在pBA5-FRT背景中复制pFG40Ad基因组末端。
ΔE1ΔE3第一代载体，BAd19 E1 E3-GFP是在HAdV-D64(以前创造的Ad19a)26的ME菌株的基础上构建的，也分两步针对体内末端接近进行了定制。首先，右侧ITR的侧翼是标记有氨苄青霉素抗性的弹头序列，然后，左侧ITR的侧翼是标记有Kn抗性的弹头序列的第二拷贝，通过重组工程使用引物对64REfor/64RErev和64LEfor/64LErev扩增的相应PCR片段导致pBWH-D64M-GFP。
从头构建用于CRISPR/Cas介导的末端解析(CTR)的rAd基因组
为了新构建能够进行CRISPR/Cas介导的末端解析的细菌质粒或BAC，我们使用Gibson组装34将纯化的基因组Ad DNA与PCR扩增的细菌载体序列组装在一起。本研究中用于从头构建rAd的一般工作流程如图3所示。
为了新生成可以通过CRISPR/Cas介导的末端解析来拯救的rAd，我们从物种C衍生的第一代rAd载体制备构建了rAd质粒(创造为pAC05-CE1)。如上所述，从Ad5-CMV/mChe(Sirion Biotech，普兰尼格，德国)感染的293A细胞中分离出基因组rAd DNA。根据制造商的说明(New England Biolabs，法兰克福，德国)使用NEBuilder试剂组装基因组Ad DNA，并使用通过PCR在pAR-19模板上生成的PCR扩增载体片段。PCR是用引物(LWHC5for/GHLrev和LWHC5rev/GHLfor)进行的，引物侧翼有弹头序列，分别与左侧和右侧ITR具有40bp同源性。由此产生的构建体也能够表达sgRNA-Ex并在右侧ITR附近携带rox位点用于Dre重组。NEB10beta细胞通过组装混合物进行电转化，并在氯霉素平板上进行选择。通过RFLP挑选单个菌落进行分析，并通过下一代测序验证选定的克隆。
通过使用Dre-3SR将质粒pH-gRNA-Cas9-Flag插入pAC05-CE1构建pAC05-mChe-Cas9。
在大肠杆菌中克隆重组HAdV-B3和HAdV-E4原则上遵循与上述相同的方案。在HAdV-B3的情况下(引物GHLrev/LWHBfor；GHLfor/LWHBrev)使用Litmus28(NEB，法兰克福，德国)和在HAdV-E4的情况下使用pKSB229制备，使用重叠延伸PCR生成用于Gibson组装的载体片段(引物GHBrev/BWHE4for；GHBfor/BWHE4rev)。在这些情况下，最终构建体不具备表达sgRNA的能力。根据制造商的说明使用NEBuilder试剂组装构建体。然后将2微升这种成品组装混合物电转化为有能力的大肠杆菌。分别在Amp和Cam+平板上选择B3和E4克隆的转化体。通过挑选和RFLP分析单个菌落，并通过下一代测序验证选定的克隆。经验证的分子克隆分别被命名为pLWH-B3和pBWH-E4。由于本研究中使用的基于HAdV-5的构建体都携带E3缺失以获得相当的基因组大小以用于拯救实验，我们通过重组工程删除了nt 27.002和nt 31.348之间的E3区域(根据参考序列GenBank登录号AY594253)。该构建体被创造为pBWH-E4-DE3，并在本研究中用于定量拯救实验(图5D)。
此外，重组猿猴Ad-BACmid(命名为pBWH-SE25)是从猿猴物种E腺病毒的基因组DNA构建的，该腺病毒从如上所述的感染细胞中分离出来。使用NEBuilder试剂根据制造商的说明(New England Biolabs，法兰克福，德国)与通过PCR在pKSB2模板上产生的两个PCR扩增载体片段组装基因组Ad DNA。PCR是用引物(GHBrev/BWHES25for和GHBfor和BWHES25rev)进行的，引物侧翼有弹头序列，并且分别与左侧和右侧ITR具有40bp同源性。NEB10beta细胞通过组装混合物进行电转化，并在氯霉素平板上进行选择。通过挑选和RFLP分析单个菌落，并通过下一代测序验证选定的克隆，并将其命名为pBWH-SE25。
通过末端解析拯救rAd
按照制造商的说明，使用NucleoBond Xtra-Midi-Kit(Macherey Nagel，恩辛根，瑞士)通过柱纯化从细菌中分离出待转染的DNA，并直接用于环状构建体的转染。如果线性化DNA被转染，5μg柱纯化DNA在100μl反应体积中使用30单位的核酸内切酶PacI(NewEngland Biolabs，法兰克福，德国)消化过夜。然后通过添加乙酸钠至终浓度为0.3M和3vol.无水乙醇(Honeywell，夏洛特，北卡罗来纳州，美国)。并在冰上沉淀1小时来沉淀DNA。然后通过离心收集DNA沉淀物并用乙醇(70％)洗涤两次。将沉淀物干燥并重新悬浮在40μl无菌H2O中。
根据制造商的说明，使用Lipofectamine 3000(ThermoFischer Scientific，沃尔瑟姆，马萨诸塞州，美国)进行293A、A549、A549-Cas9或293-Cas9细胞的转染。将6μlLipofectamine和5μl P3000用于转染混合物，其中包含1μg rAd质粒和(如果需要)500ng(摩尔比，1:3)辅助质粒DNA，应用于一百万个细胞，在转染前24小时接种。
将转染混合物直接添加到细胞培养基中，并将细胞孵育过夜。然后，通过胰蛋白酶消化收集转染的细胞，并将～1.25×105个活细胞接种到24孔板的至少4个孔中。每天观察细胞的灶/斑块形成，并在第一个灶/斑块出现一天后对灶/斑块进行计数。在没有斑块形成的情况下，观察培养物14天，然后得出阴性结论。最终灶/斑块计数归一化为1μg DNA。
下一代测序
根据制造商的说明，通过来自Macherey Nagel(迪伦，德国)的Xtra-Midi-kit从大肠杆菌中分离质粒或BAC DNA，通过应用组织培养试剂盒(Macherey Nagel，迪伦，德国)从感染细胞分离DNA。测序由Eurofins NSG服务使用Illumina MiSeq平台(1.5GB包)完成，并由Geneious Prime软件按照其参考序列介导的工作流程进行分析。
示例的结果
将重组腺病毒基因组与CRISPR-Cas9介导的末端分析相匹配
在转染允许细胞以拯救重组病毒之前，rAd基因组通常通过限制性核酸内切酶处理从其环状重组形式中释放出来(图1A)。本示例中描述的Ad拯救方法基于将Cas9核酸酶活性靶向与质粒或BAC克隆的Ad基因组的ITR相邻的序列，以便在转染后释放体内基因组末端(末端解析)(图1B)，允许腺病毒DNA复制。因此，CRISPR/Cas复合体的靶序列应位于紧邻两个ITR或与ITR部分重叠，使得实际Cas9介导的切割应发生在克隆的Ad基因组附近或末端(图1C)。为了测试这一原理，我们修改了Ad5(物种C)载体，这是最常用的重组Ad平台。我们插入了人工CRISPR/Cas靶序列，称为弹头(5’-TAATTGCAGTGGACCCCGG-3’(SEQ ID NO.30))；连同所需的PAM(5’-CGG-3’)在BAC的每个ITR分两步克隆第一代Ad5载体基因组。首先，将反向互补弹头序列直接插入pBAd5-FRT3右侧ITR的下游(图1B)。其次，我们通过相应修改的穿梭载体携带CMV启动子驱动的mCherry报告基因的Flp介导的插入30将弹头序列直接引入rAd5供体载体的左侧ITR上游。PAM的位置使我们能够用与ITR(Ex)外部的弹头序列互补的靶序列引导Cas9，或者与ITR(In)部分重叠(参见图1C)。为了表达Cas9核酸酶和适当的sgRNA，我们构建了一个单独的表达质粒，携带两个所需的转录单位(pAR-gRNA-Cas9-Amp。)我们还处理了两个对照构建体；一个包含(pBAd5-mChe)(根据标准方法35拯救的第一代rAd5基因组)；另一个对照包含pBAd5-FG40-GFP，也是第一代rAd5基因组，但它没有正常的ITR，而是具有Graham等人10描述的ITR融合体，表明在环状DNA转染后重组病毒的与通过体外线性化的常用方法一样高效。
通过CRISPR/Cas9介导的体内末端解析拯救第一代rAd载体。
在pBWH-C5-mChe和pAR-gRNA-Cas9-Amp共转染后，以及将线性化标准构建体或ITR融合的对照载体转染到293A细胞后，我们可以观察到斑块形成。然而，与线性拯救或ITR融合驱动的环状拯救(在转染后约9至11天产生灶)相比，CRISPR-Cas驱动的拯救产生了数量多得多的斑块(参见图2B)，并且可以在转染后3-4天明显更早地观察到灶。在我们手中，ITR融合构建体的拯救显示出略高的效率，尽管据报道效率与通过酶促线性化10重建相比是相等的。每当将环状pBWH-C5-mChe单独转染到293A中时，它在观察期(14天)内都没有产生感染性颗粒，表明Ad5-Warheads-mChe载体的拯救需要功能性CRISPR-Cas系统的存在(见图2B)。
接下来，我们想研究CRISPR/Cas介导的载体拯救是否也在源自另一物种Ad的重组Ad基因组的背景下发挥作用。因此，我们修改了重组HAdV-D64载体26以在其ITR侧翼携带相同的弹头序列，如上文针对Ad5所述(参见图1C)。请注意，由于设计原因，ITR外部的弹头序列(Ex方向)可以靶向Cas9核酸酶以通过通用gRNA切割ITR，而不管实际的ITR序列和要拯救的rAd基因组的类型。在用弹头修饰的物种D BAC pBWH-D64-GFP和pAR-gRNA-Cas9-Amp共转染293A细胞后，我们在转染后7天首先观察到病毒斑块形成，而在转染64-BAC26的PacI线性化版本后约14天斑块形成。此外，与线性化构建体的拯救相比，CRISPR/Cas介导的末端解析后载体拯救的效率再次显著提高(参见图2C)。
为了测试提供CRISPR/Cas辅助功能的最有效方法，我们首先将所有组件合并到一个构建体中，以避免共转染的不确定性。因此，我们构建了表达mCherry的rAd5BAC，除了弹头定制载体基因组(pBWH-C5-mChe-Cas9)之外，它还携带两个辅助转录单元。从该构建体中获救rAd5的效率与从双质粒环境中获救的效率一样(图2D)。
接下来，我们想确定Cas9的活性是否是体内末端解析所必需的。因此，我们通过用DD结构域调节的Cas9编码序列替换wt酶的ORF来修改Cas9表达单元27。DD结构域修饰的Cas9不稳定，因此在转染后活性低于wt Cas9。然而，它可以通过添加Shield-1(一种小分子稳定剂36)来稳定和恢复功能。我们在不存在和存在Shield-1的情况下用表达DDD-Cas9的构建体转染293A细胞。正如预期的那样，在不稳定的核酸酶存在的情况下，环状构建体转染后的拯救效率会急剧下降，而这种功能丧失几乎可以通过添加Shield-1来完全避免。该数据表明，弹头介导的末端解析对rAd的拯救确实依赖于Cas9活性。
将所有组件放在一个构建体中会大大增加重组DNA的大小，这不是问题，因为我们使用BAC克隆的基因组进行这些测试。然而，BAC构建体并不是高效应用的最佳选择，因为高拷贝质粒制剂的DNA质量优于BAC制剂的质量。因此，为了限制一体化构建体的大小，我们生成了一个基于293A细胞的细胞系，该细胞系在SV40早期启动子的控制下稳定表达Flag标记的SpCas9。测试了19个Cas9阳性克隆在共转染pBWH-C5-mChe和pAR-gRNA-Ex(一种表达sgRNA-Ex的构建体)后介导载体拯救的能力，并选择了克隆293A-Cas9-B2用于进一步研究，因为它能够支持末端解析，此外，还表达了最高水平的Cas9(见图4)。手头有表达Cas9的互补细胞系，使我们能够测试基于高拷贝质粒的弹头rAd构建体的效率，我们用pAC05-CE1转染了293A-Cas9-B2细胞。作为对照，我们用基本的Ad5BAC构建体pBWH-C5-mChe和pAR-gRNA-Ex共转染293A-Cas9-B2，或者用pBWH-C5-Cas9共转染293A细胞，其携带在一个构建体内有体内末端解析所需的所有组件。我们在所有三种环境中观察到具有相同动力学和效率的斑块形成(图2F)。因此，我们得出结论，CRISPR/Cas9组件可以从靶细胞系或通过(共)转染质粒提供用于体内末端解析，而不影响拯救效率。在ITR外插入Cas9核酸酶复合物的功能靶序列使我们能够使用通用gRNA进行在各种构建体进行拯救实验，甚至基于来自不同腺病毒物种的基因组拯救rAd。然而，基于这种设计，Cas9切割的性质只允许在距离基因组末端相对较远的位点(6-7个碱基对)进行DNA线性化。虽然这可能不是最佳的，但显然足以引起末端解析，如上所示。为了在更接近或甚至恰好在基因组末端诱导切割，我们设计了另一种sgRNA(sgRNA-Int)，它将Cas9活性靶向ITR末端，并从弹头序列中获取其PAM(见图1C)。为了评估更近距离切割的效率，我们分别用pBWH-C5-mChe与pSG5-Cas9和pAR-gRNA-Ex或pAR-gRNA-IntC5(5’-CTCCGTAGTAGTTATTATAT-3’(SEQ ID NO.31))共转染293A细胞。相比之下，pAR-gRNA-IntC5同时诱导的灶几乎是pAR-gRNA-Ex的三倍(图2G)，表明更靠近ITR的切割确实比远距离切割更有效。然而，靠近Ad基因组末端的设计需要特定的gRNA，靶向具有不同序列的ITR，这也可能以不同的(例如，不可预测的)效率进行处理。因此，我们使用pAR-gRNA-Ex或pAR-gRNA-IntD64(5’-ATTATTAGATAGTTAATTA-3’(SEQ ID NO.32))测试了pBWH-D64-GFP的拯救。如图2G所示，由Int构建体拯救的rAd的产量也增加了，但这对于物种D基因组的拯救没有达到统计学意义。这些数据表明，Cas9核酸酶位点越近，病毒拯救的效率就越好，但这种效率的程度很可能取决于实际靶序列，因此需要对每个新构建体进行测试。
如图2G所示，对于基于HAdV-C5的构建体，基于sgRNA-IntC5的CTR产生的病灶是使用sgRNA-Ex的CTR的两倍多，表明近端切割比远距离切割诱导更有效的拯救。为了进一步证实我们的结论，即切割位点与基因组末端的距离很重要，我们还分析了更远的切割位点对CTR的影响。我们构建了一个新的基于rAd5的构建体pBWH18/19-C5-mChe，它使Wh12碱基对远离ITR末端(参见图5A下图)。在此构建体上，sgRNA-Ex应诱导Cas9切割18/19核苷酸远离ITR末端。测试此设置的拯救效率表明，与其他两种设置相比，重组病毒拯救显著降低，如果与sgRNA-Ex介导的CTR或sgRNA-Int5介导的精确切割相比，则切割更接近(图5B)(如图2G)。这些数据证实，切割位点的位置对于基于rAd5的构建体的拯救效率是确定性的。
为了测试仅针对rAd基因组一个末端的CRISPR/Cas介导的末端解析是否足以拯救病毒，我们构建了rAd5 BACmids，其携带位于左侧(pBWH-R-C5-mChe)或右侧IRT(pBWH-R-C5-mChe)侧翼的CRISPR/Cas靶序列。这些构建体与原始HAdV-5-BACmid pBWH-C5-mChe(其携带位于其两个ITR侧翼的靶序列)一起，与pAR-gRNA-Ex共转染至293-Cas9细胞。如上所述，通过确定初级病灶形成来量化病毒拯救。如图2H所示，两个单一ITR标记构建体的环状DNA转染产生了病毒拯救。然而，与双标记的原始构建体相比，病毒拯救的效率有所降低。这种拯救效率的降低对于两个版本都是可见的，但仅对于携带位于右侧ITR侧翼的CRISPR/Cas靶标的构建体而言具有统计学意义。
具有CRISPR-Cas介导的末端解析的rAd新构建途径
如上所示，我们可以修改已经克隆的rAd基因组，以使它们与CRISPR/Cas介导的末端解析兼容。然而，我们也想测试基于CRISPR/Cas介导的拯救直接构建重组Ad是否可行。这可能不是微不足道的，因为引入完全相同的CRISPR/Cas靶序列会扩大位于基因组两侧的反向重复序列的大小。因此，我们设计了一个工作流程，用于使用扩展有弹头序列的ITR重组构建rAd质粒和BAC。为了测试这种方法，我们使用Gibson组装将野生型HAdV-B3和HAdV-E4基因组分别与高拷贝质粒和BAC载体相关联(详见图3和材料与方法部分)。这种方法导致细菌构建体携带侧翼有弹头的感染性rAd基因组(创造为pLWH-B03，用于HAdV-B03编码质粒，和pBWH-E04用于HAdV-E04编码杆粒)。在将pBWH-E04或pLWH-B03与pAR-gRNA-Ex共转染到A549-Cas924中后，我们在转染后4-6天内获得了具有斑块形成的感染性病毒的拯救。繁殖拯救的病毒，并通过下一代测序验证两个拯救的wt rAd分子克隆(一个用于B3，一个用于E4)的序列，并与从各自的起始病毒原种制备的原始基因组进行比较。该数据表明，带有弹头序列的ITR的扩大不影响rAd基因组的重组克隆，并且体内末端解析可以在不同细胞系中发挥作用。
我们还以同样的方式构建了携带猿猴腺病毒25型基因组DNA的BACmid。我们用纯化的BAC DNA转染了293-Cas9细胞，纯化的BAC DNA是由pBWH-SE25的两个序列验证克隆和辅助质粒pAR-gRNA-Ex制备的，如上所述。每天观察转染培养物的斑块形成。两个克隆都拯救了病毒，因为在转染后10-12天观察到斑块形成。两种拯救上清液都得到繁殖，并且两种拯救的wt SAdV-25分子克隆的序列都通过下一代测序进行了验证，并且与从各自的起始病毒原种制备的原始基因组相同。这些数据表明CRISPR/Cas介导的体内末端解析适用于拯救源自动物宿主物种的重组腺病毒。
为测试载体骨架中携带弹头序列部分同源性的gRNA转录单元的存在是否会影响我们新工作流程中rAd质粒组装的效率，我们将从通过Gibson组装的感染细胞中分离的Ad5-mCherry载体基因组重新克隆到PCR扩增的pAR19载体片段。这产生了pAC05-CE1。我们没有观察到使用携带pAR19载体片段的gRNA转录单元进行Gibson组装后的菌落形成与在用于克隆物种B和E Ad的标准载体实验中观察到的菌落形成之间的任何显著差异。初始病毒DNA的NGS与新拯救的Ad5-mChe-WH的比较证实，新的克隆程序和CRISPR/Cas介导的病毒拯救都不影响rAd的一级序列。
ITR附近的CRISPR-Cas介导的细胞裂解产生了基于HAdV-4的重组腺病毒的有效拯救
由于与基于HAdV-5的rAd的传统拯救方法相比，CTR后的初级拯救效率有所提高，因此我们想定量测试衍生自另一种腺病毒物种的rAd的CTR效率。为此，构建和修改了基于HAdV-4(物种E)的新rAd-bacmid(参见图5C中的ITR近序列与rAd5构建体的比较)，以便与基于HAdV-5的构建体进行更精确的比较，通过删除E3区域得到杆粒pBWH-E4-DE3。在用该杆粒和表达sgRNA-Ex和Cas9的辅助质粒pAR-gRNA-Cas9-Amp共转染293A细胞后，我们再次观察到病毒斑块形成。为了测试精确切割对基于HAdV-4的载体的影响，我们构建了一个新的辅助质粒，它表达了将Cas9核酸酶精确引导到HAdV-4基因组末端的sgRNA(pAR-gRNA-Int4，见图5D)。同样，对于基于HAdV-5的拯救，由精确切割诱导的CTR大大提高了拯救效率，表明以精确切割释放rAd末端提高了拯救效率。
示例讨论
重组Ad是体外和体内应用中最常用的病毒基因转移载剂之一。具有复制能力的rAd载体的生成已经很成熟。然而，从rAd质粒和杆粒中拯救载体是低效的。迄今为止，这阻止了该载体平台在任何基于转染后直接病毒拯救的技术中的使用，例如非辅助依赖性复制缺陷构建体的繁殖或基因组库应用。通过质粒转染繁殖高容量辅助无病毒rAd载体是可能的，但这种方法的效率很低。据先前报道，为了制备足以进行体内小鼠实验的病毒原种，需要转染约100个大组织培养皿37。因此，为了繁殖用于人类基因治疗的载体，这种方法无疑需要更高的效率。它的低效率可能是由相同的因素决定的，这对于拯救我们在本研究中使用的具有复制能力的载体很重要。我们发现，与使用线性DNA的传统方法相比，使用体内末端解析可将rAd重组的效率提高20-30倍。通过操纵Cas9的切割位点，这可以进一步增加三倍。测试这种整体80-100倍的效率提高是否可以转移到新描述的高容量rAd的基于质粒的繁殖将是有趣的。此外，我们相信，使用此处描述的新方法通过rAd拯救获得效率将允许构建基于rAd载体的库，其大小与慢病毒库相当。在最佳条件下，我们的新系统产生了大约30个斑块/cm2的细胞培养物。当转染代表20-30个大细胞培养皿的大规模细胞培养物时，这转化为具有104-105个单独克隆的库的生成，分别包含总共约8.7x104-1.3x105个单独的rAd克隆)。这与优化慢病毒库产品的多样性和繁殖条件相当38。然而，这两个平台之间存在相当大的差异，这与此类高内容库的扩增潜力有关。虽然慢病毒制剂的最大滴度约为～109颗粒/ml，但rAd滴度可以达到高达～1013颗粒/ml的滴度39。
最后，由本文方法所述的直接从质粒制剂拯救感染性rA的可能性为基于质粒递送后体内拯救病毒的新方法铺平了道路。这将允许设计一类新的疫苗，在将DNA传递给疫苗接种者后，这种疫苗将繁殖病毒颗粒以实现最佳免疫。与使用重组病毒颗粒进行疫苗接种相比，直接DNA递送更安全、更易于应用且更经济，因为它不需要冷链40。
据我们所知，这里呈现的CTR是允许在野生型ITR的末端从其环状形式精确切割rAd基因组的首个方法。我们的数据显示了准确切割与释放ITR的相关性，因为与更远的切割相比，近端切割导致显著更高的腺病毒拯救(图2B和5B)。这可以解释为什么限制性核酸内切酶介导的方法相对低效，因为它们总是在线性化rAd基因组的两端留下额外的核苷酸。
通过精确切割，物种C构建体的拯救提高了2-3倍，物种E构建体的拯救提高了6倍以上。根据计算机内活动评分(J.G.Doench,E.Hartenian,D.B.Graham,Z.Tothova,M.Hegde,I.Smith,M.Sullender,B.L.Ebert,R.J.Xavier and D.E.Root:Rational designof highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.NatBiotechnol,32(12),1262-7(2014))sgRNA-Ex(靶向E4和C5的活性得分分别为0.715和0.808)远比Int5或Int4更活跃(分别为0.069和0.067)，这绝对不能解释Int5或Int4引起的拯救效率的显著提高。我们认为，较弱的精确切割位点比远处位置最活跃的切割位点更有效地拯救这一事实强烈支持CTR效率的关键点是精确切割的能力。基于sgRNA-Ex的CTR对于HAdV-4拯救的效率低于HAdV-5拯救，但精确的切割导致增加，这使得基于HAdV-4的构建体几乎达到HAdV-5的水平，再次表明精确切割达到高效rAd拯救的重要性。这表明，与基于HAdV-5的研究最广泛的系统相比，远距离切割后掩蔽核苷酸的负面影响在其他物种(例如此处显示的物种E)中可能更成问题。
确定ITR与ITR外部的Cas9切割侧之间的优选距离并进一步提高效率
构建了新的杆粒，其携带侧翼带有用于Cas9切割靶序列的rAD基因组，这些靶序列与ITR的距离比上述示例中描述的更远(例如ITR外部约10-20个碱基对)，以找出多远可以从ITR的外末端移动Cas9切割。将转染这些构建体后的病毒拯救效率与构建体的拯救效率进行比较，后者在共表达适当的gRNA和Cas9表达的情况下在最近的可能外部位点被切割。特别是，比较了Cas9切割0/1、6/7、12/13和18/19核苷酸形成ITR的构建体的效率。还可以测试距离ITR更远距离切割的构建体。这些实验提供了有关成功拯救rAd的Cas9靶序列最远有用位置的信息。
sgRNA Int5和Int4的活性分数明显低于sgRNA Ex的活性分数。相比之下，靶向Int5和Int4位点的拯救效率要高得多。这清楚地表明主要因素是决定CTR效率的切割位点的距离。然而，尚不清楚切割效率是否起着可测量的作用。我们还在测试由Doench评分测量的切割效率对精确切割拯救效率的影响。通过修改ITR可变的前8个位置以及ITR和PAM序列之间的4个核苷酸，可以设计新的基因组末端和侧翼序列，这允许使用比这里表示的Int5和Int4设置的Doench评分高4-6倍的sgRNA。看看CRISPR/Cas靶向的改进是否会在多大程度上影响不同构建体的拯救效率将会很有趣。
示例表
表1.示例的寡核苷酸
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Figure BDA0004152002130000401
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Figure BDA0004152002130000411
表2.合成DNA片段
Figure BDA0004152002130000412
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Figure BDA0004152002130000421
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Figure BDA0004152002130000431
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Figure BDA0004152002130000441
表3.示例中所用的质粒构建体
Figure BDA0004152002130000442
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Figure BDA0004152002130000451
*Hashimoto-Gotoh,T.,Franklin,F.C.,Nordheim,A.&Timmis,K.N.Specific-purpose plasmid cloning vectors.I.Low copy number,temperature-sensitive,mobilization-defective pSC101-derived containment vectors.Gene 16,227-235,doi:10.1016/0378-1119(81)90079-2(1981).
表4.重组腺病毒质粒和BAC
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Figure BDA0004152002130000461
*Graham,F.L.Covalently closed circles of human adenovirus DNA areinfectious.The EMBO journal 3,2917-2922(1984).
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10Graham,F.L.Covalently closed circles of human adenovirus DNA areinfectious.The EMBO journal 3,2917-2922(1984).
11Hille,F.&Charpentier,E.CRISPR-Cas:biology,mechanisms andrelevance.Philosophical transactions of the Royal Society of London.Series B,Biological sciences 371,doi:10.1098/rstb.2015.0496(2016).
12Cong,L.et al.Multiplex genome engineering using CRISPR/Cassystems.Science 339,819-823,doi:10.1126/science.1231143(2013).
13Chu,V.T.et al.Increasing the efficiency of homology-directed repairfor CRISPR-Cas9-induced precise gene editing in mammalian cells.NatBiotechnol 33,543-548,doi:10.1038/nbt.3198(2015).
14Suenaga,T.,Kohyama,M.,Hirayasu,K.&Arase,H.Engineering large viralDNA genomes using the CRISPR-Cas9 system.Microbiol Immunol 58,513-522,doi:10.1111/1348-0421.12180(2014).
15 Bi,Y.et al.High-efficiency targeted editing of large viral genomesby RNA-guided nucleases.PLoS Pathog 10,e1004090,doi:10.1371/journal.ppat.1004090(2014).
16 Mali,P.et al.RNA-guided human genome engineering via Cas9.Science339,823-826,doi:10.1126/science.1232033(2013).
17 Hsu,P.D.,Lander,E.S.&Zhang,F.Development and applications ofCRISPR-Cas9 forgenome engineering.Cell 157,1262-1278,doi:10.1016/j.cell.2014.05.010(2014).
18 Rouet,P.,Smih,F.&Jasin,M.Introduction of double-strand breaks intothe genome of mouse cells by expression of a rare-cutting endonuclease.MolCell Biol 14,8096-8106,doi:10.1128/mcb.14.12.8096(1994).
19 Rouet,P.,Smih,F.&Jasin,M.Expression of a site-specificendonuclease stimulateshomologous recombination in mammaliancells.Proceedings of the National Academy of Sciences of the United States ofAmerica 91,6064-6068,doi:10.1073/pnas.91.13.6064(1994).
20 Jiang,F.et al.Structures of a CRISPR-Cas9 R-loop complex primedfor DNA cleavage.Science 351,867-871,doi:10.1126/science.aad8282(2016).
21 Jinek,M.et al.Structures of Cas9 endonucleases reveal RNA-mediatedconformational activation.Science 343,1247997,doi:10.1126/science.1247997(2014).
22 Graham,F.L.,Smiley,J.,Russell,W.C.&Nairn,R.Characteristics of ahuman cell line transformed by DNA from human adenovirus type 5.The Journalof general virology 36,59-74,doi:10.1099/0022-1317-36-1-59(1977).
23 Fallaux,F.J.et al.Characterization of 911:a new helper cell linefor the titration and propagation of early region 1-deleted adenoviralvectors.Hum Gene Ther 7,215-222,
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24 Karakus,U.et al.MHC class II proteins mediate cross-species entryof bat influenza viruses.Nature 567,109-112,doi:10.1038/s41586-019-0955-3(2019).
25 Hashimoto-Gotoh,T.,Franklin,F.C.,Nordheim,A.&Timmis,K.N.Specific-purpose plasmid cloning vectors.I.Low copy number,temperature-sensitive,mobilization-defective pSC101-derived containment vectors.Gene 16,227-235,doi:10.1016/0378-1119(81)90079-2(1981).
26 Ruzsics,Z.et al.Transposon-assisted cloning and tracelessmutagenesis of adenoviruses:Development of a novel vector based on speciesD.Journal of virology 80,8100-8113,doi:10.1128/JVI.00687-06(2006).
27 Senturk,S.et al.Rapid and tunable method to temporally controlgene editing based on conditional Cas9 stabilization.Nature communications 8,14370,doi:10.1038/ncomms14370(2017).28 Yuen,K.S.,Chan,C.P.,Kok,K.H.&Jin,D.Y.Mutagenesis and Genome Engineering of Epstein-Barr Virus in CulturedHuman Cells by CRISPR/Cas9.Methods Mol Biol 1498,23-31,doi:10.1007/978-1-4939-6472-7_2(2017).
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序列表
<110> 阿尔伯特-路德维希-弗赖堡大学
<120> 通过CRISPR/CAS介导的体内末端解析拯救重组腺病毒
<130> 2124/20WO
<150> EP 20198944.9
<151> 2020-09-29
<160> 64
<170> BiSSAP 1.3.6
<210> 1
<211> 31
<212> DNA
<213> 人工序列
<220>
<223> AmpEcoRI
<400> 1
gtgtgaattc gtcaggtggc acttttcggg g 31
<210> 2
<211> 31
<212> DNA
<213> 人工序列
<220>
<223> AmpPacI
<400> 2
gtgtttaatt aaacttggtc tgacagttac c 31
<210> 3
<211> 27
<212> DNA
<213> 人工序列
<220>
<223> AmpXho_for
<400> 3
gtgtctcgag tcaggtggca cttttcg 27
<210> 4
<211> 31
<212> DNA
<213> 人工序列
<220>
<223> pUCNsi_rev
<400> 4
gtgtatgcat cgcaggaaag aacatgtgag c 31
<210> 5
<211> 21
<212> DNA
<213> 人工序列
<220>
<223> Cas9for
<400> 5
gtgtaccggt tctagagcca c 21
<210> 6
<211> 22
<212> DNA
<213> 人工序列
<220>
<223> Cas9rev
<400> 6
ctgaagatct cttgcagata gc 22
<210> 7
<211> 29
<212> DNA
<213> 人工序列
<220>
<223> gRNANsi_for
<400> 7
gtgtatgcat tatcgtttca gacccacct 29
<210> 8
<211> 32
<212> DNA
<213> 人工序列
<220>
<223> gRNAEcoR_rev
<400> 8
tgtggaattc aagcttaaaa aagcaccgac tc 32
<210> 9
<211> 59
<212> DNA
<213> 人工序列
<220>
<223> Warhead-L-ITR19a_for
<400> 9
gtgtttaatt aataattgca gtggaccccg gaggctatct aataatatac cccacaaag 59
<210> 10
<211> 23
<212> DNA
<213> 人工序列
<220>
<223> Warhead-L-ITR19a_rev
<400> 10
tgtgcatatg atacacttga tgt 23
<210> 11
<211> 40
<212> DNA
<213> 人工序列
<220>
<223> GHBfor
<400> 11
ccgcgtgtgt acctctacct ggagtttttc ccacggtgga 40
<210> 12
<211> 40
<212> DNA
<213> 人工序列
<220>
<223> GHBrev
<400> 12
tccaccgtgg gaaaaactcc aggtagaggt acacacgcgg 40
<210> 13
<211> 40
<212> DNA
<213> 人工序列
<220>
<223> GHLfor
<400> 13
gtctatcagg gcgatggccc actacgtgaa ccatcaccca 40
<210> 14
<211> 40
<212> DNA
<213> 人工序列
<220>
<223> GHLrev
<400> 14
tgggtgatgg ttcacgtagt gggccatcgc cctgatagac 40
<210> 15
<211> 88
<212> DNA
<213> 人工序列
<220>
<223> BWHE4for
<400> 15
ttaactcaca caaaaaaaat aaggtatatt atatagatag cctccggggt ccactgcaat 60
tacttctcga ccaattctca tgtttgac 88
<210> 16
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> BWHE4rev
<400> 16
ttaactcaca caaaaaaaat aaggtatatt atatagatag cctccggggt ccactgcaat 60
tataaactcg acagcgacac acttgc 86
<210> 17
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> LWHB3for
<400> 17
gttggcacca ttccatctat aaggtatatt atatagatag cctccggggt ccactgcaat 60
taggtaccct ctagtcaagg ccttaa 86
<210> 18
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> LWHB3rev
<400> 18
gttggcacca ttccatctat aaggtatatt atatagatag cctccggggt ccactgcaat 60
tacggtgcgc gcgatgcatt cgaaga 86
<210> 19
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> LWHC5for
<400> 19
tattggcttc aatccaaaat aaggtatatt attgatgatg cctccggggt ccactgcaat 60
taggtaccct ctagtcaagg ccttaa 86
<210> 20
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> LWHC5rev
<400> 20
tattggcttc aatccaaaat aaggtatatt attgatgatg cctccggggt ccactgcaat 60
tacggtgcgc gcgatgcatt cgaaga 86
<210> 21
<211> 75
<212> DNA
<213> 人工序列
<220>
<223> 64LEfor
<400> 21
tgaatggcag aaattcgatg ataagctgtc aaacatgaga atgggtcgag aacaggttga 60
actgctgatc ttcag 75
<210> 22
<211> 101
<212> DNA
<213> 人工序列
<220>
<223> 64LErev
<400> 22
tcatttgcat attaactttt gtttactttg tggggtatat tattagatag cctccggggt 60
ccactgcaat tattaattaa gccagtgtta caaccaatta a 101
<210> 23
<211> 91
<212> DNA
<213> 人工序列
<220>
<223> 64REfor
<400> 23
tcatttgcat attaactttt gtttactttg tggggtatat tattagatag cctccggggt 60
ccactgcaat tataacttta aataatgcca a 91
<210> 24
<211> 72
<212> DNA
<213> 人工序列
<220>
<223> 64RErev
<400> 24
atccgatgca agtgtgtcgc tgtcgagttt aaacatgcat ccttaattaa acgcgtttac 60
caatgcttaa tc 72
<210> 25
<211> 88
<212> DNA
<213> 人工序列
<220>
<223> BWHSE25for
<400> 25
taacgcgcac aaaaagtttg aggtatatta ttgatgatgg cctccggggt ccactgcaat 60
tacttctcga ccaattctca tgtttgac 88
<210> 26
<211> 86
<212> DNA
<213> 人工序列
<220>
<223> BWHSE25rev
<400> 26
taacgcgcac aaaaagtttg aggtatatta ttgaagatgg cctccggggt ccactgcaat 60
tataaactcg acagcgacac acttgc 86
<210> 27
<211> 1732
<212> DNA
<213> 人工序列
<220>
<223> loxE4Amp
<400> 27
ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc gacacggcac ataacttcgt 60
atagcataca ttatacgaag ttatcagctc aatcagtcac agtgtaaaaa agggccaagt 120
gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac 180
ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct 240
caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa aactacaatt 300
cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc 360
cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt 420
atattattga tgatgttaat taagggcggc cgcacgggcc atcgatgggg atccatccgc 480
ggagaagctt ctcgaccaat tctcatgttt gacagcttat catcgaattt ctgccattca 540
tccgcttatt atcacttatt caggcgtagc aaccaggcgt ttaagggcac caataactgc 600
cttaaaaaaa aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg 660
cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg 720
actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc 780
aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc 840
cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa 900
ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc 960
cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg 1020
ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc 1080
cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat 1140
ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg 1200
tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc 1260
ggcgtcaaca cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg 1320
agaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat 1380
gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg 1440
gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg 1500
ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct 1560
catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac 1620
atttccccga aaagtgccac ctgacgtagt taacaaaaaa aagcccgccg aagcgggctt 1680
tatttagctt ccttagctcc tgaaaatctc gataactcaa aaaatacgcc cg 1732
<210> 28
<211> 1374
<212> DNA
<213> 人工序列
<220>
<223> ROXITRCam
<400> 28
ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc gacacggcac cagctcaatc 60
agtcacagtg taaaaaaggg ccaagtgcag agcgagtata tataggacta aaaaatgacg 120
taacggttaa agtccacaaa aaacacccag aaaaccgcac gcgaacctac gcccagaaac 180
gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc cgttttccca cgttacgtca 240
cttcccattt taagaaaact acaattccca acacatacaa gttactccgc cctaaaacct 300
acgtcacccg ccccgttccc acgccccgcg ccacgtcaca aactccaccc cctcattatc 360
atattggctt caatccaaaa taaggtatat tattgatgat gcctccgggg tccactgcaa 420
ttaataactt cgtatagcat acattatacg aagttattta attaagggcg gccgcacggg 480
ccatcgatgg ggatcctaac tttaaataat gccaattatt taaagttaat ccgcggagaa 540
gcttctcgac caattctcat gtttgacagc ttatcatcga atttctgcca ttcatccgct 600
tattatcact tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa 660
aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc 720
cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct 780
tgtcgccttg cgtataatat ttgcccatgg tgaaaacggg ggcgaagaag ttgtccatat 840
tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca 900
tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt 960
gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa 1020
acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca 1080
gctcaccgtc tttcattgcc atacggaatt ccggatgagc attcatcagg cgggcaagaa 1140
tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg 1200
taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa 1260
aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct 1320
ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccg 1374
<210> 29
<211> 1145
<212> DNA
<213> 人工序列
<220>
<223> Waroxamp
<400> 29
tcatttgcat attaactttt gtttactttg tggggtatat tattagatag cctccggggt 60
ccactgcaat tataacttta aataatgcca attatttaaa gttaatccgc ggagaacgcg 120
tgccgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 180
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 240
catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 300
ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 360
atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttc 420
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc 480
gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 540
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 600
ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 660
gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 720
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg 780
gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 840
ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 900
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt 960
gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 1020
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 1080
cattggtaaa cgcgtttaat taaggatgca tgtttaaact cgacagcgac acacttgcat 1140
cggat 1145
<210> 30
<211> 19
<212> DNA
<213> 人工序列
<220>
<223> 弹头靶向序列
<400> 30
taattgcagt ggaccccgg 19
<210> 31
<211> 20
<212> DNA
<213> 人工序列
<220>
<223> gRNA-IntC5
<400> 31
ctccgtagta gttattatat 20
<210> 32
<211> 19
<212> DNA
<213> 人工序列
<220>
<223> gRNA-IntD64
<400> 32
attattagat agttaatta 19
<210> 33
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图1的上序列
<400> 33
aaataaggta tattattgat gatgcctccg gggtccactg caattaataa cttcgtat 58
<210> 34
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图1的下序列
<400> 34
atacgaagtt attaattgca gtggaccccg gaggcatcat caataatata ccttattt 58
<210> 35
<211> 3496
<212> DNA
<213> 人工序列
<220>
<223> pO6-A5-mChe-WH
<400> 35
taacatatgg atttattcaa caaagccacg ttgtgtctca aaatctctga tgttacattg 60
cacaagataa aaatatatca tcatgaacaa taaaactgtc tgcttacata aacagtaata 120
caaggggtgt tatgagccat attcaacggg aaacgtcttg ctcgaggccg cgattaaatt 180
ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc gggcaatcag 240
gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg 300
gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac tggctgacgg 360
aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat gcatggttac 420
tcaccactgc gatccccggg aaaacagcat tccaggtatt agaagaatat cctgattcag 480
gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg attcctgttt 540
gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga 600
ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg cctgttgaac 660
aagtctggaa agaaatgcat aagcttttgc cattctcacc ggattcagtc gtcactcatg 720
gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt tgtattgatg 780
ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg aactgcctcg 840
gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt gataatcctg 900
atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaatca gaattggtta 960
attggttgta acactgggca tgctaattgc agtggacccc ggaggcatca tcaataatat 1020
accttatttt ggattgaagc caatatgata atgagggggt ggagtttgtg acgtggcgcg 1080
gggcgtggga acggggcggg tgacgtagta gtgtggcgga agtgtgatgt tgcaagtgtg 1140
gcggaacaca tgtaagcgac ggatgtggca aaagtgacgt ttttggtgtg cgccggtgta 1200
cacaggaagt gacaattttc gcgcggtttt aggcggatgt tgtagtaaat ttgggcgtaa 1260
ccgagtaaga tttggccatt ttcgcgggaa aactgaataa gaggaagtga aatctgaata 1320
attttgtgtt actcatagcg cgtaattact gaatagtaat caattacggg gtcattagtt 1380
catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga 1440
ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca 1500
atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca 1560
gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg 1620
cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc 1680
tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt 1740
ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt 1800
ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg 1860
acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tggtttagtg 1920
aaccgtcaga tccgctagcg ctaccggact cagatctcga gctcaagctt cgaattctgc 1980
agtcgacggt accgagctcg gatcccgcca ccatggtgag caagggcgag gaggataaca 2040
tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc gtgaacggcc 2100
acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc cagaccgcca 2160
agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg tcccctcagt 2220
tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac tacttgaagc 2280
tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg 2340
tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacaag gtgaagctgc 2400
gcggcaccaa cttcccctcc gacggccccg taatgcagaa gaagaccatg ggctgggagg 2460
cctcctccga gcggatgtac cccgaggacg gcgccctgaa gggcgagatc aagcagaggc 2520
tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa gaccacctac aaggccaaga 2580
agcccgtgca gctgcccggc gcctacaacg tcaacatcaa gttggacatc acctcccaca 2640
acgaggacta caccatcgtg gaacagtacg aacgcgccga gggccgccac tccaccggcg 2700
gcatggacga gctgtacaag taagaattct gcagatatcc agcacagtgg cggccgcgac 2760
tctagatcat aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc 2820
cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta 2880
ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat 2940
ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct taaatcgaat 3000
tcaagcttgt cgactcgaag atctgagctc acgcgtgaag ttcctattct ctagaaagta 3060
taggaacttc aattcccatg tcagccgtta agtgttcctg tgtcactcaa aattgctttg 3120
agaggctcta agggcttctc agtgcgttac atccctggct tgttgtccac aaccgttaaa 3180
ccttaaaagc tttaaaagcc ttatatattc ttttttttct tataaaactt aaaaccttag 3240
aggctattta agttgctgat ttatattaat tttattgttc aaacatgaga gcttagtacg 3300
tgaaacatga gagcttagta cgttagccat gagagcttag tacgttagcc atgagggttt 3360
agttcgttaa acatgagagc ttagtacgtt aaacatgaga gcttagtacg tgaaacatga 3420
gagcttagta cgtactatca acaggttgaa ctgctgatct tcagatcctc tacgccggac 3480
gcatcgtggc cttaat 3496
<210> 36
<211> 40933
<212> DNA
<213> 人工序列
<220>
<223> pBWH-C5-mChe
<400> 36
gtagtgatct tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc 60
attttcgcca aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt 120
attctgcgaa gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt 180
aaccgtcgca caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc 240
aggacctgga ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt 300
ccggtcacac cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata 360
ccgctgaaag ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac 420
acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag 480
tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat 540
ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt 600
atccactgag aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat 660
tattaatctc aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc 720
aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg 780
ttacgttgaa gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa 840
ccatgatgtg gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag 900
ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat 960
gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt tataattatt 1020
ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg 1080
ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac 1140
agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt 1200
tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa 1260
cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac 1320
gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct 1380
cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca 1440
ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg 1500
gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga 1560
aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt 1620
ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca 1680
acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta 1740
gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt 1800
atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt 1860
accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct 1920
gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag 1980
gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat 2040
agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact 2100
gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt 2160
ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt 2220
ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt 2280
tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt 2340
tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc 2400
ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta 2460
gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat 2520
tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat 2580
tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat 2640
ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc 2700
acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga 2760
agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg 2820
actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat 2880
tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt 2940
atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc 3000
tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa 3060
cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc 3120
agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa 3180
gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga 3240
aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct 3300
ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc 3360
taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac 3420
gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct 3480
gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata 3540
cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg 3600
aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg 3660
gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa 3720
tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg 3780
ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa 3840
ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg 3900
cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg 3960
aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca 4020
ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct 4080
tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa 4140
attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt 4200
ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg taacgattat 4260
cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt 4320
gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc 4380
tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa 4440
ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt 4500
aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa 4560
gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta 4620
agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg 4680
cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt 4740
aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct 4800
ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg 4860
cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt 4920
atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 4980
tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt 5040
cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg 5100
tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 5160
aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 5220
tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta 5280
tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga 5340
ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt 5400
aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa 5460
cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta 5520
accgggctgc atccgatgca agtgtgtcgc tgtcgagttt tcgggggagt ccagggtttt 5580
cccagtcacg acgttgtaaa acgacggcca gtgaattcga gctcggtacc cggggatctt 5640
gaagttccta ttctctagaa agtataggaa cttcaattcc catgtcagcc gttaagtgtt 5700
cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 5760
ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 5820
ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 5880
gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 5940
ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 6000
gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 6060
atcttcagat cctctacgcc ggacgcatcg tggccttaat taacatatgg atttattcaa 6120
caaagccacg ttgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca 6180
tcatgaacaa taaaactgtc tgcttacata aacagtaata caaggggtgt tatgagccat 6240
attcaacggg aaacgtcttg ctcgaggccg cgattaaatt ccaacatgga tgctgattta 6300
tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgattg 6360
tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat 6420
gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc 6480
atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccggg 6540
aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg 6600
ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc 6660
gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg 6720
agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat 6780
aagcttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac 6840
cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca 6900
gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta 6960
cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt 7020
catttgatgc tcgatgagtt tttctaatca gaattggtta attggttgta acactgggca 7080
tgctaattgc agtggacccc ggaggcatca tcaataatat accttatttt ggattgaagc 7140
caatatgata atgagggggt ggagtttgtg acgtggcgcg gggcgtggga acggggcggg 7200
tgacgtagta gtgtggcgga agtgtgatgt tgcaagtgtg gcggaacaca tgtaagcgac 7260
ggatgtggca aaagtgacgt ttttggtgtg cgccggtgta cacaggaagt gacaattttc 7320
gcgcggtttt aggcggatgt tgtagtaaat ttgggcgtaa ccgagtaaga tttggccatt 7380
ttcgcgggaa aactgaataa gaggaagtga aatctgaata attttgtgtt actcatagcg 7440
cgtaataata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg 7500
ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga 7560
cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat 7620
gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa 7680
gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca 7740
tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca 7800
tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 7860
ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 7920
actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 7980
ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagcgctacc 8040
ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccga gctcggatcc 8100
cgccaccatg gtgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg 8160
cttcaaggtg cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg 8220
cgagggccgc ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc 8280
cctgcccttc gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt 8340
gaagcacccc gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg 8400
ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct 8460
gcaggacggc gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg 8520
ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga 8580
ggacggcgcc ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta 8640
cgacgctgag gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta 8700
caacgtcaac atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca 8760
gtacgaacgc gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaaga 8820
attctgcaga tatccagcac agtggcggcc gcgactctag atcataatca gccataccac 8880
atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 8940
taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 9000
aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 9060
tttgtccaaa ctcatcaatg tatcttaaat cgaattcaag cttgtcgact cgaagatctg 9120
agctcacgcg tgaagttcct attccgaagt tcctattctc tagaaagtat aggaacttca 9180
gagcgctttt gaagctgggg tgggcgaaga actccagcat gagatcccca gagcgctttt 9240
gaagctgcgt ttaaacgcga tatcccggga gctcccgata tcgcgtttaa acgcagcttg 9300
gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 9360
aacatacgag ccggaagact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 9420
aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 9480
ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 9540
ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 9600
actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 9660
ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 9720
gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 9780
ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 9840
atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 9900
taaataaaaa accagactct gtttggattt ggatcaagca agtgtcttgc tgtctttatt 9960
taggggtttt gcgcgcgcgg taggcccggg accagcggtc tcggtcgttg agggtcctgt 10020
gtattttttc caggacgtgg taaaggtgac tctggatgtt cagatacatg ggcataagcc 10080
cgtctctggg gtggaggtag caccactgca gagcttcatg ctgcggggtg gtgttgtaga 10140
tgatccagtc gtagcaggag cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc 10200
tgattgccag gggcaggccc ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt 10260
gcatacgtgg ggatatgaga tgcatcttgg actgtatttt taggttggct atgttcccag 10320
ccatatccct ccggggattc atgttgtgca gaaccaccag cacagtgtat ccggtgcact 10380
tgggaaattt gtcatgtagc ttagaaggaa atgcgtggaa gaacttggag acgcccttgt 10440
gacctccaag attttccatg cattcgtcca taatgatggc aatgggccca cgggcggcgg 10500
cctgggcgaa gatatttctg ggatcactaa cgtcatagtt gtgttccagg atgagatcgt 10560
cataggccat ttttacaaag cgcgggcgga gggtgccaga ctgcggtata atggttccat 10620
ccggcccagg ggcgtagtta ccctcacaga tttgcatttc ccacgctttg agttcagatg 10680
gggggatcat gtctacctgc ggggcgatga agaaaacggt ttccggggta ggggagatca 10740
gctgggaaga aagcaggttc ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa 10800
tcacacctat taccgggtgc aactggtagt taagagagct gcagctgccg tcatccctga 10860
gcaggggggc cacttcgtta agcatgtccc tgactcgcat gttttccctg accaaatccg 10920
ccagaaggcg ctcgccgccc agcgatagca gttcttgcaa ggaagcaaag tttttcaacg 10980
gtttgagacc gtccgccgta ggcatgcttt tgagcgtttg accaagcagt tccaggcggt 11040
cccacagctc ggtcacctgc tctacggcat ctcgatccag catatctcct cgtttcgcgg 11100
gttggggcgg ctttcgctgt acggcagtag tcggtgctcg tccagacggg ccagggtcat 11160
gtctttccac gggcgcaggg tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc 11220
tccgggctgc gcgctggcca gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg 11280
ccggtcttcg ccctgcgcgt cggccaggta gcatttgacc atggtgtcat agtccagccc 11340
ctccgcggcg tggcccttgg cgcgcagctt gcccttggag gaggcgccgc acgaggggca 11400
gtgcagactt ttgagggcgt agagcttggg cgcgagaaat accgattccg gggagtaggc 11460
atccgcgccg caggccccgc agacggtctc gcattccacg agccaggtga gctctggccg 11520
ttcggggtca aaaaccaggt ttcccccatg ctttttgatg cgtttcttac ctctggtttc 11580
catgagccgg tgtccacgct cggtgacgaa aaggctgtcc gtgtccccgt atacagactt 11640
gagaggcctg tcctcgagcg gtgttccgcg gtcctcctcg tatagaaact cggaccactc 11700
tgagacaaag gctcgcgtcc aggccagcac gaaggaggct aagtgggagg ggtagcggtc 11760
gttgtccact agggggtcca ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc 11820
atcaaggaag gtgattggtt tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg 11880
gctataaaag ggggtggggg cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag 11940
ggccagctgt tggggtgagt actccctctg aaaagcgggc atgacttctg cgctaagatt 12000
gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag 12060
ggtggccgca tccatctggt cagaaaagac aatctttttg ttgtcaagct tggtggcaaa 12120
cgacccgtag agggcgttgg acagcaactt ggcgatggag cgcagggttt ggtttttgtc 12180
gcgatcggcg cgctccttgg ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg 12240
ccattcggga aagacggtgg tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt 12300
gtgcagggtg acaaggtcaa cgctggtggc tacctctccg cgtaggcgct cgttggtcca 12360
gcagaggcgg ccgcccttgc gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc 12420
cggggggtct gcgtccacgg taaagacccc gggcagcagg cgcgcgtcga agtagtctat 12480
cttgcatcct tgcaagtcta gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta 12540
tgggttgagt gggggacccc atggcatggg gtgggtgagc gcggaggcgt acatgccgca 12600
aatgtcgtaa acgtagaggg gctctctgag tattccaaga tatgtagggt agcatcttcc 12660
accgcggatg ctggcgcgca cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg 12720
accgaggttg ctacgggcgg gctgctctgc tcggaagact atctgcctga agatggcatg 12780
tgagttggat gatatggttg gacgctggaa gacgttgaag ctggcgtctg tgagacctac 12840
cgcgtcacgc acgaaggagg cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac 12900
ctgcacgtct agggcgcagt agtccagggt ttccttgatg atgtcatact tatcctgtcc 12960
cttttttttc cacagctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg 13020
gatcggaaac ccgtcggcct ccgaacggta agagcctagc atgtagaact ggttgacggc 13080
ctggtaggcg cagcatccct tttctacggg tagcgcgtat gcctgcgcgg ccttccggag 13140
cgaggtgtgg gtgagcgcaa aggtgtccct gaccatgact ttgaggtact ggtatttgaa 13200
gtcagtgtcg tcgcatccgc cctgctccca gagcaaaaag tccgtgcgct ttttggaacg 13260
cggatttggc agggcgaagg tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa 13320
gttgcgtgtg atgcggaagg gtcccggcac ctcggaacgg ttgttaatta cctgggcggc 13380
gagcacgatc tcgtcaaagc cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg 13440
cgggatgccc ttgatggaag gcaatttttt aagttcctcg taggtgagct cttcagggga 13500
gctgagcccg tgctctgaaa gggcccagtc tgcaagatga gggttggaag cgacgaatga 13560
gctccacagg tcacgggcca ttagcatttg caggtggtcg cgaaaggtcc taaactggcg 13620
acctatggcc attttttctg gggtgatgca gtagaaggta agcgggtctt gttcccagcg 13680
gtcccatcca aggttcgcgg ctaggtctcg cgcggcagtc actagaggct catctccgcc 13740
gaacttcatg accagcatga agggcacgag ctgcttccca aaggccccca tccaagtata 13800
ggtctctaca tcgtaggtga caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa 13860
gaactggatc tcccgccacc aattggagga gtggctattg atgtggtgaa agtagaagtc 13920
cctgcgacgg gccgaacact cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg 13980
gtgcacgggc tgtacatcct gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag 14040
tgggaatttg agcccctcgc ctggcgggtt tggctggtgg tcttctactt cggctgcttg 14100
tccttgaccg tctggctgct cgaggggagt tacggtggat cggaccacca cgccgcgcga 14160
gcccaaagtc cagatgtccg cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg 14220
ggagctgtcc atggtctgga gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt 14280
tacctcgcat agacgggtca gggcgcgggc tagatccagg tgatacctaa tttccagggg 14340
ctggttggtg gcggcgtcga tggcttgcaa gaggccgcat ccccgcggcg cgactacggt 14400
accgcgcggc gggcggtggg ccgcgggggt gtccttggat gatgcatcta aaagcggtga 14460
cgcgggcgag cccccggagg tagggggggc tccggacccg ccgggagagg gggcaggggc 14520
acgtcggcgc cgcgcgcggg caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg 14580
acgacgcggc ggttgatctc ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg 14640
agcttgagcc tgaaagagag ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg 14700
cgcaaaatct cctgcacgtc tcctgagttg tcttgatagg cgatctcggc catgaactgc 14760
tcgatctctt cctcctggag atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg 14820
ttggaaatgc gggccatgag ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg 14880
ctgtagacca cgcccccttc ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc 14940
tccacgtgcc gggcgaagac ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg 15000
gtggcggtgt gttctgccac gaagaagtac ataacccagc gtcgcaacgt ggattcgttg 15060
atatccccca aggcctcaag gcgctccatg gcctcgtaga agtccacggc gaagttgaaa 15120
aactgggagt tgcgcgccga cacggttaac tcctcctcca gaagacggat gagctcggcg 15180
acagtgtcgc gcacctcgcg ctcaaaggct acaggggcct cttcttcttc ttcaatctcc 15240
tcttccataa gggcctcccc ttcttcttct tctggcggcg gtgggggagg ggggacacgg 15300
cggcgacgac ggcgcaccgg gaggcggtcg acaaagcgct cgatcatctc cccgcggcga 15360
cggcgcatgg tctcggtgac ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg 15420
cccgtcatgt cccggttatg ggttggcggg gggctgccat gcggcaggga tacggcgcta 15480
acgatgcatc tcaacaattg ttgtgtaggt actccgccgc cgagggacct gagcgagtcc 15540
gcatcgaccg gatcggaaaa cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt 15600
aggctgagca ccgtggcggg cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg 15660
ctgctgatga tgtaattaaa gtaggcggtc ttgagacggc ggatggtcga cagaagcacc 15720
atgtccttgg gtccggcctg ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt 15780
tgacatcggc gcaggtcttt gtagtagtct tgcatgagcc tttctaccgg cacttcttct 15840
tctccttcct cttgtcctgc atctcttgca tctatcgctg cggcggcggc ggagtttggc 15900
cgtaggtggc gccctcttcc tcccatgcgt gtgaccccga agcccctcat cggctgaagc 15960
agggctaggt cggcgacaac gcgctcggct aatatggcct gctgcacctg cgtgagggta 16020
gactggaagt catccatgtc cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg 16080
cagttggcca taacggacca gttaacggtc tggtgacccg gctgcgagag ctcggtgtac 16140
ctgagacgcg agtaagccct cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac 16200
tggtatccca ccaaaaagtg cggcggcggc tggcggtaga ggggccagcg tagggtggcc 16260
ggggctccgg gggcgagatc ttccaacata aggcgatgat atccgtagat gtacctggac 16320
atccaggtga tgccggcggc ggtggtggag gcgcgcggaa agtcgcggac gcggttccag 16380
atgttgcgca gcggcaaaaa gtgctccatg gtcgggacgc tctggccggt caggcgcgcg 16440
caatcgttga cgctctagac cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg 16500
tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag ccccgtatcc 16560
ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc 16620
agacaacggg ggagtgctcc ttttggcttc cttccaggcg cggcggctgc tgcgctagct 16680
tttttggcca ctggccgcgc gcagcgtaag cggttaggct ggaaagcgaa agcattaagt 16740
ggctcgctcc ctgtagccgg agggttattt tccaagggtt gagtcgcggg acccccggtt 16800
cgagtctcgg accggccgga ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc 16860
ccgcttgcaa attcctccgg aaacagggac gagccccttt tttgcttttc ccagatgcat 16920
ccggtgctgc ggcagatgcg cccccctcct cagcagcggc aagagcaaga gcagcggcag 16980
acatgcaggg caccctcccc tcctcctacc gcgtcaggag gggcgacatc cgcggttgac 17040
gcggcagcag atggtgatta cgaacccccg cggcgccggg cccggcacta cctggacttg 17100
gaggagggcg agggcctggc gcggctagga gcgccctctc ctgagcggta cccaagggtg 17160
cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc 17220
gagggagagg agcccgagga gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg 17280
catggcctga atcgcgagcg gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc 17340
gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc tggtaaccgc atacgagcag 17400
acggtgaacc aggagattaa ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg 17460
gcgcgcgagg aggtggctat aggactgatg catctgtggg actttgtaag cgcgctggag 17520
caaaacccaa atagcaagcc gctcatggcg cagctgttcc ttatagtgca gcacagcagg 17580
gacaacgagg cattcaggga tgcgctgcta aacatagtag agcccgaggg ccgctggctg 17640
ctcgatttga taaacatcct gcagagcata gtggtgcagg agcgcagctt gagcctggct 17700
gacaaggtgg ccgccatcaa ctattccatg cttagcctgg gcaagtttta cgcccgcaag 17760
atataccata ccccttacgt tcccatagac aaggaggtaa agatcgaggg gttctacatg 17820
cgcatggcgc tgaaggtgct taccttgagc gacgacctgg gcgtttatcg caacgagcgc 17880
atccacaagg ccgtgagcgt gagccggcgg cgcgagctca gcgaccgcga gctgatgcac 17940
agcctgcaaa gggccctggc tggcacgggc agcggcgata gagaggccga gtcctacttt 18000
gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg ccctggaggc agctggggcc 18060
ggacctgggc tggcggtggc acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat 18120
gacgaggacg atgagtacga gccagaggac ggcgagtact aagcggtgat gtttctgatc 18180
agatgatgca agacgcaacg gacccggcgg tgcgggcggc gctgcagagc cagccgtccg 18240
gccttaactc cacggacgac tggcgccagg tcatggaccg catcatgtcg ctgactgcgc 18300
gcaatcctga cgcgttccgg cagcagccgc aggccaaccg gctctccgca attctggaag 18360
cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc 18420
tggccgaaaa cagggccatc cggcccgacg aggccggcct ggtctacgac gcgctgcttc 18480
agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg 18540
atgtgcgcga ggccgtggcg cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca 18600
tggttgcact aaacgccttc ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg 18660
actacaccaa ctttgtgagc gcactgcggc taatggtgac tgagacaccg caaagtgagg 18720
tgtaccagtc tgggccagac tattttttcc agaccagtag acaaggcctg cagaccgtaa 18780
acctgagcca ggctttcaaa aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg 18840
accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag 18900
cgcccttcac ggacagtggc agcgtgtccc gggacacata cctaggtcac ttgctgacac 18960
tgtaccgcga ggccataggt caggcgcatg tggacgagca tactttccag gagattacaa 19020
gtgtcagccg cgcgctgggg caggaggaca cgggcagcct ggaggcaacc ctaaactacc 19080
tgctgaccaa ccggcggcag aagatcccct cgttgcacag tttaaacagc gaggaggagc 19140
gcattttgcg ctacgtgcag cagagcgtga gccttaacct gatgcgcgac ggggtaacgc 19200
ccagcgtggc gctggacatg accgcgcgca acatggaacc gggcatgtat gcctcaaacc 19260
ggccgtttat caaccgccta atggactact tgcatcgcgc ggccgccgtg aaccccgagt 19320
atttcaccaa tgccatcttg aacccgcact ggctaccgcc ccctggtttc tacaccgggg 19380
gattcgaggt gcccgagggt aacgatggat tcctctggga cgacatagac gacagcgtgt 19440
tttccccgca accgcagacc ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc 19500
tgcgaaagga aagcttccgc aggccaagca gcttgtccga tctaggcgct gcggccccgc 19560
ggtcagatgc tagtagccca tttccaagct tgatagggtc tcttaccagc actcgcacca 19620
cccgcccgcg cctgctgggc gaggaggagt acctaaacaa ctcgctgctg cagccgcagc 19680
gcgaaaaaaa cctgcctccg gcatttccca acaacgggat agagagccta gtggacaaga 19740
tgagtagatg gaagacgtac gcgcaggagc acagggacgt gccaggcccg cgcccgccca 19800
cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg ggaggacgat gactcggcag 19860
acgacagcag cgtcctggat ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca 19920
ggctggggag aatgttttaa aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg 19980
ccatggcacc gagcgttggt tttcttgtat tccccttagt atgcggcgcg cggcgatgta 20040
tgaggaaggt cctcctccct cctacgagag tgtggtgagc gcggcgccag tggcggcggc 20100
gctgggttct cccttcgatg ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg 20160
gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat tcgacaccac 20220
ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca tccctgaact accagaacga 20280
ccacagcaac tttctgacca cggtcattca aaacaatgac tacagcccgg gggaggcaag 20340
cacacagacc atcaatcttg acgaccggtc gcactggggc ggcgacctga aaaccatcct 20400
gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta aggcgcgggt 20460
gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga 20520
gttcacgctg cccgagggca actactccga gaccatgacc atagacctta tgaacaacgc 20580
gatcgtggag cactacttga aagtgggcag acagaacggg gttctggaaa gcgacatcgg 20640
ggtaaagttt gacacccgca acttcagact ggggtttgac cccgtcactg gtcttgtcat 20700
gcctggggta tatacaaacg aagccttcca tccagacatc attttgctgc caggatgcgg 20760
ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt 20820
ccaggagggc tttaggatca cctacgatga tctggagggt ggtaacattc ccgcactgtt 20880
ggatgtggac gcctaccagg cgagcttgaa agatgacacc gaacagggcg ggggtggcgc 20940
aggcggcagc aacagcagtg gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc 21000
aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct ttgccacacg 21060
ggctgaggag aagcgcgctg aggccgaagc agcggccgaa gctgccgccc ccgctgcgca 21120
acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag aggacagcaa 21180
gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc gcagctggta 21240
ccttgcatac aactacggcg accctcagac cggaatccgc tcatggaccc tgctttgcac 21300
tcctgacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca tgatgcaaga 21360
ccccgtgacc ttccgctcca cgcgccagat cagcaacttt ccggtggtgg gcgccgagct 21420
gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc aactcatccg 21480
ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 21540
cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg 21600
gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta ctgacgccag 21660
acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc gcgtcctatc 21720
gagccgcact ttttgagcaa gcatgtccat ccttatatcg cccagcaata acacaggctg 21780
gggcctgcgc ttcccaagca agatgtttgg cggggccaag aagcgctccg accaacaccc 21840
agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg 21900
gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag gaggcgcgca actacacgcc 21960
cacgccgcca ccagtgtcca cagtggacgc ggccattcag accgtggtgc gcggagcccg 22020
gcgctatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc gccgccgacc 22080
cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg 22140
acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt attgtcactg tgccccccag 22200
gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga ctcagggtcg 22260
caggggcaac gtgtattggg tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac 22320
ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact gttgtatgta 22380
tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatcaaag aagagatgct 22440
ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg attacaagcc 22500
ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga 22560
ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt 22620
aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg cccggtgagc gctccacccg 22680
cacctacaag cgcgtgtatg atgaggtgta cggcgacgag gacctgcttg agcaggccaa 22740
cgagcgcctc ggggagtttg cctacggaaa gcggcataag gacatgctgg cgttgccgct 22800
ggacgagggc aacccaacac ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc 22860
gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag tctggtgact tggcacccac 22920
cgtgcagctg atggtaccca agcgccagcg actggaagat gtcttggaaa aaatgaccgt 22980
ggaacctggg ctggagcccg aggtccgcgt gcggccaatc aagcaggtgg cgccgggact 23040
gggcgtgcag accgtggacg ttcagatacc cactaccagt agcaccagta ttgccaccgc 23100
cacagagggc atggagacac aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt 23160
gcaggcggtc gctgcggccg cgtccaagac ctctacggag gtgcaaacgg acccgtggat 23220
gtttcgcgtt tcagcccccc ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc 23280
gctactgccc gaatatgccc tacatccttc cattgcgcct acccccggct atcgtggcta 23340
cacctaccgc cccagaagac gagcaactac ccgacgccga accaccactg gaacccgccg 23400
ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga 23460
aggaggcagg accctggtgc tgccaacagc gcgctaccac cccagcatcg tttaaaagcc 23520
ggtctttgtg gttcttgcag atatggccct cacctgccgc ctccgtttcc cggtgccggg 23580
attccgagga agaatgcacc gtaggagggg catggccggc cacggcctga cgggcggcat 23640
gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct 23700
gcccctcctt attccactga tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt 23760
ggccttgcag gcgcagagac actgattaaa aacaagttgc atgtggaaaa atcaaaataa 23820
aaagtctgga ctctcacgct cgcttggtcc tgtaactatt ttgtagaatg gaagacatca 23880
actttgcgtc tctggccccg cgacacggct cgcgcccgtt catgggaaac tggcaagata 23940
tcggcaccag caatatgagc ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta 24000
aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc ctggaacagc agcacaggcc 24060
agatgctgag ggataagttg aaagagcaaa atttccaaca aaaggtggta gatggcctgg 24120
cctctggcat tagcggggtg gtggacctgg ccaaccaggc agtgcaaaat aagattaaca 24180
gtaagcttga tccccgccct cccgtagagg agcctccacc ggccgtggag acagtgtctc 24240
cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa 24300
tagacgagcc tccctcgtac gaggaggcac taaagcaagg cctgcccacc acccgtccca 24360
tcgcgcccat ggctaccgga gtgctgggcc agcacacacc cgtaacgctg gacctgcctc 24420
cccccgccga cacccagcag aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc 24480
gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag 24540
ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg tctgggggtg caatccctga 24600
agcgccgacg atgcttctga atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg 24660
tcgccgccag aggagctgct gagccgccgc gcgcccgctt tccaagatgg ctaccccttc 24720
gatgatgccg cagtggtctt acatgcacat ctcgggccag gacgcctcgg agtacctgag 24780
ccccgggctg gtgcagtttg cccgcgccac cgagacgtac ttcagcctga ataacaagtt 24840
tagaaacccc acggtggcgc ctacgcacga cgtgaccaca gaccggtccc agcgtttgac 24900
gctgcggttc atccctgtgg accgtgagga tactgcgtac tcgtacaagg cgcggttcac 24960
cctagctgtg ggtgataacc gtgtgctgga catggcttcc acgtactttg acatccgcgg 25020
cgtgctggac aggggcccta cttttaagcc ctactctggc actgcctaca acgccctggc 25080
tcccaagggt gccccaaatc cttgcgaatg ggatgaagct gctactgctc ttgaaataaa 25140
cctagaagaa gaggacgatg acaacgaaga cgaagtagac gagcaagctg agcagcaaaa 25200
aactcacgta tttgggcagg cgccttattc tggtataaat attacaaagg agggtattca 25260
aataggtgtc gaaggtcaaa cacctaaata tgccgataaa acatttcaac ctgaacctca 25320
aataggagaa tctcagtggt acgaaactga aattaatcat gcagctggga gagtccttaa 25380
aaagactacc ccaatgaaac catgttacgg ttcatatgca aaacccacaa atgaaaatgg 25440
agggcaaggc attcttgtaa agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca 25500
atttttctca actactgagg cgaccgcagg caatggtgat aacttgactc ctaaagtggt 25560
attgtacagt gaagatgtag atatagaaac cccagacact catatttctt acatgcccac 25620
tattaaggaa ggtaactcac gagaactaat gggccaacaa tctatgccca acaggcctaa 25680
ttacattgct tttagggaca attttattgg tctaatgtat tacaacagca cgggtaatat 25740
gggtgttctg gcgggccaag catcgcagtt gaatgctgtt gtagatttgc aagacagaaa 25800
cacagagctt tcataccagc ttttgcttga ttccattggt gatagaacca ggtacttttc 25860
tatgtggaat caggctgttg acagctatga tccagatgtt agaattattg aaaatcatgg 25920
aactgaagat gaacttccaa attactgctt tccactggga ggtgtgatta atacagagac 25980
tcttaccaag gtaaaaccta aaacaggtca ggaaaatgga tgggaaaaag atgctacaga 26040
attttcagat aaaaatgaaa taagagttgg aaataatttt gccatggaaa tcaatctaaa 26100
tgccaacctg tggagaaatt tcctgtactc caacatagcg ctgtatttgc ccgacaagct 26160
aaagtacagt ccttccaacg taaaaatttc tgataaccca aacacctacg actacatgaa 26220
caagcgagtg gtggctcccg ggttagtgga ctgctacatt aaccttggag cacgctggtc 26280
ccttgactat atggacaacg tcaacccatt taaccaccac cgcaatgctg gcctgcgcta 26340
ccgctcaatg ttgctgggca atggtcgcta tgtgcccttc cacatccagg tgcctcagaa 26400
gttctttgcc attaaaaacc tccttctcct gccgggctca tacacctacg agtggaactt 26460
caggaaggat gttaacatgg ttctgcagag ctccctagga aatgacctaa gggttgacgg 26520
agccagcatt aagtttgata gcatttgcct ttacgccacc ttcttcccca tggcccacaa 26580
caccgcctcc acgcttgagg ccatgcttag aaacgacacc aacgaccagt cctttaacga 26640
ctatctctcc gccgccaaca tgctctaccc tatacccgcc aacgctacca acgtgcccat 26700
atccatcccc tcccgcaact gggcggcttt ccgcggctgg gccttcacgc gccttaagac 26760
taaggaaacc ccatcactgg gctcgggcta cgacccttat tacacctact ctggctctat 26820
accctaccta gatggaacct tttacctcaa ccacaccttt aagaaggtgg ccattacctt 26880
tgactcttct gtcagctggc ctggcaatga ccgcctgctt acccccaacg agtttgaaat 26940
taagcgctca gttgacgggg agggttacaa cgttgcccag tgtaacatga ccaaagactg 27000
gttcctggta caaatgctag ctaactacaa cattggctac cagggcttct atatcccaga 27060
gagctacaag gaccgcatgt actccttctt tagaaacttc cagcccatga gccgtcaggt 27120
ggtggatgat actaaataca aggactacca acaggtgggc atcctacacc aacacaacaa 27180
ctctggattt gttggctacc ttgcccccac catgcgcgaa ggacaggcct accctgctaa 27240
cttcccctat ccgcttatag gcaagaccgc agttgacagc attacccaga aaaagtttct 27300
ttgcgatcgc accctttggc gcatcccatt ctccagtaac tttatgtcca tgggcgcact 27360
cacagacctg ggccaaaacc ttctctacgc caactccgcc cacgcgctag acatgacttt 27420
tgaggtggat cccatggacg agcccaccct tctttatgtt ttgtttgaag tctttgacgt 27480
ggtccgtgtg caccggccgc accgcggcgt catcgaaacc gtgtacctgc gcacgccctt 27540
ctcggccggc aacgccacaa cataaagaag caagcaacat caacaacagc tgccgccatg 27600
ggctccagtg agcaggaact gaaagccatt gtcaaagatc ttggttgtgg gccatatttt 27660
ttgggcacct atgacaagcg ctttccaggc tttgtttctc cacacaagct cgcctgcgcc 27720
atagtcaata cggccggtcg cgagactggg ggcgtacact ggatggcctt tgcctggaac 27780
ccgcactcaa aaacatgcta cctctttgag ccctttggct tttctgacca gcgactcaag 27840
caggtttacc agtttgagta cgagtcactc ctgcgccgta gcgccattgc ttcttccccc 27900
gaccgctgta taacgctgga aaagtccacc caaagcgtac aggggcccaa ctcggccgcc 27960
tgtggactat tctgctgcat gtttctccac gcctttgcca actggcccca aactcccatg 28020
gatcacaacc ccaccatgaa ccttattacc ggggtaccca actccatgct caacagtccc 28080
caggtacagc ccaccctgcg tcgcaaccag gaacagctct acagcttcct ggagcgccac 28140
tcgccctact tccgcagcca cagtgcgcag attaggagcg ccacttcttt ttgtcacttg 28200
aaaaacatgt aaaaataatg tactagagac actttcaata aaggcaaatg cttttatttg 28260
tacactctcg ggtgattatt tacccccacc cttgccgtct gcgccgttta aaaatcaaag 28320
gggttctgcc gcgcatcgct atgcgccact ggcagggaca cgttgcgata ctggtgttta 28380
gtgctccact taaactcagg cacaaccatc cgcggcagct cggtgaagtt ttcactccac 28440
aggctgcgca ccatcaccaa cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag 28500
ttggggcctc cgccctgcgc gcgcgagttg cgatacacag ggttgcagca ctggaacact 28560
atcagcgccg ggtggtgcac gctggccagc acgctcttgt cggagatcag atccgcgtcc 28620
aggtcctccg cgttgctcag ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag 28680
ggcgcgtgcc caggctttga gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc 28740
ccggtctggg cgttaggata cagcgcctgc ataaaagcct tgatctgctt aaaagccacc 28800
tgagcctttg cgccttcaga gaagaacatg ccgcaagact tgccggaaaa ctgattggcc 28860
ggacaggccg cgtcgtgcac gcagcacctt gcgtcggtgt tggagatctg caccacattt 28920
cggccccacc ggttcttcac gatcttggcc ttgctagact gctccttcag cgcgcgctgc 28980
ccgttttcgc tcgtcacatc catttcaatc acgtgctcct tatttatcat aatgcttccg 29040
tgtagacact taagctcgcc ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc 29100
gtgggctcgt gatgcttgta ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat 29160
cgccccatca tcgtcacaaa ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc 29220
tcctcgttca gccaggtctt gcatacggcc gccagagctt ccacttggtc aggcagtagt 29280
ttgaagttcg cctttagatc gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc 29340
tccatgccct tctcccacgc agacacgatc ggcacactca gcgggttcat caccgtaatt 29400
tcactttccg cttcgctggg ctcttcctct tcctcttgcg tccgcatacc acgcgccact 29460
gggtcgtctt cattcagccg ccgcactgtg cgcttacctc ctttgccatg cttgattagc 29520
accggtgggt tgctgaaacc caccatttgt agcgccacat cttctctttc ttcctcgctg 29580
tccacgatta cctctggtga tggcgggcgc tcgggcttgg gagaagggcg cttctttttc 29640
ttcttgggcg caatggccaa atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc 29700
ggcaccagcg cgtcttgtga tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc 29760
cgcttttttg ggggcgcccg gggaggcggc ggcgacgggg acggggacga cacgtcctcc 29820
atggttgggg gacgtcgcgc cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc 29880
tcttcccgac tggccatttc cttctcctat aggcagaaaa agatcatgga gtcagtcgag 29940
aagaaggaca gcctaaccgc cccctctgag ttcgccacca ccgcctccac cgatgccgcc 30000
aacgcgccta ccaccttccc cgtcgaggca cccccgcttg aggaggagga agtgattatc 30060
gagcaggacc caggttttgt aagcgaagac gacgaggacc gctcagtacc aacagaggat 30120
aaaaagcaag accaggacaa cgcagaggca aacgaggaac aagtcgggcg gggggacgaa 30180
aggcatggcg actacctaga tgtgggagac gacgtgctgt tgaagcatct gcagcgccag 30240
tgcgccatta tctgcgacgc gttgcaagag cgcagcgatg tgcccctcgc catagcggat 30300
gtcagccttg cctacgaacg ccacctattc tcaccgcgcg taccccccaa acgccaagaa 30360
aacggcacat gcgagcccaa cccgcgcctc aacttctacc ccgtatttgc cgtgccagag 30420
gtgcttgcca cctatcacat ctttttccaa aactgcaaga tacccctatc ctgccgtgcc 30480
aaccgcagcc gagcggacaa gcagctggcc ttgcggcagg gcgctgtcat acctgatatc 30540
gcctcgctca acgaagtgcc aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg 30600
gcaaacgctc tgcaacagga aaacagcgaa aatgaaagtc actctggagt gttggtggaa 30660
ctcgagggtg acaacgcgcg cctagccgta ctaaaacgca gcatcgaggt cacccacttt 30720
gcctacccgg cacttaacct accccccaag gtcatgagca cagtcatgag tgagctgatc 30780
gtgcgccgtg cgcagcccct ggagagggat gcaaatttgc aagaacaaac agaggagggc 30840
ctacccgcag ttggcgacga gcagctagcg cgctggcttc aaacgcgcga gcctgccgac 30900
ttggaggagc gacgcaaact aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc 30960
atgcagcggt tctttgctga cccggagatg cagcgcaagc tagaggaaac attgcactac 31020
acctttcgac agggctacgt acgccaggcc tgcaagatct ccaacgtgga gctctgcaac 31080
ctggtctcct accttggaat tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc 31140
acgctcaagg gcgaggcgcg ccgcgactac gtccgcgact gcgtttactt atttctatgc 31200
tacacctggc agacggccat gggcgtttgg cagcagtgct tggaggagtg caacctcaag 31260
gagctgcaga aactgctaaa gcaaaacttg aaggacctat ggacggcctt caacgagcgc 31320
tccgtggccg cgcacctggc ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa 31380
cagggtctgc cagacttcac cagtcaaagc atgttgcaga actttaggaa ctttatccta 31440
gagcgctcag gaatcttgcc cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt 31500
aagtaccgcg aatgccctcc gccgctttgg ggccactgct accttctgca gctagccaac 31560
taccttgcct accactctga cataatggaa gacgtgagcg gtgacggtct actggagtgt 31620
cactgtcgct gcaacctatg caccccgcac cgctccctgg tttgcaattc gcagctgctt 31680
aacgaaagtc aaattatcgg tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc 31740
gcggctccgg ggttgaaact cactccgggg ctgtggacgt cggcttacct tcgcaaattt 31800
gtacctgagg actaccacgc ccacgagatt aggttctacg aagaccaatc ccgcccgcca 31860
aatgcggagc ttaccgcctg cgtcattacc cagggccaca ttcttggcca attgcaagcc 31920
atcaacaaag cccgccaaga gtttctgcta cgaaagggac ggggggttta cttggacccc 31980
cagtccggcg aggagctcaa cccaatcccc ccgccgccgc agccctatca gcagcagccg 32040
cgggcccttg cttcccagga tggcacccaa aaagaagctg cagctgccgc cgccacccac 32100
ggacgaggag gaatactggg acagtcaggc agaggaggtt ttggacgagg aggaggagga 32160
catgatggaa gactgggaga gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga 32220
cgaaacaccg tcaccctcgg tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg 32280
ttccagcatg gctacaacct ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc 32340
caaccgtaga tgggacacca ctggaaccag ggccggtaag tccaagcagc cgccgccgtt 32400
agcccaagag caacaacagc gccaaggcta ccgctcatgg cgcgggcaca agaacgccat 32460
agttgcttgc ttgcaagact gtgggggcaa catctccttc gcccgccgct ttcttctcta 32520
ccatcacggc gtggccttcc cccgtaacat cctgcattac taccgtcatc tctacagccc 32580
atactgcacc ggcggcagcg gcagcggcag caacagcagc ggccacacag aagcaaaggc 32640
gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag 32700
gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga 32760
tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa 32820
taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc 32880
agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc 32940
ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc 33000
ggccacaccc ggcgccagca cctgtcgtca gcgccattat gagcaaggaa attcccacgc 33060
cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact 33120
caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatcc 33180
gcgcccaccg aaaccgaatt ctcttggaac aggcggctat taccaccaca cctcgtaata 33240
accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca 33300
ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc 33360
ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa 33420
tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc 33480
cggacgggac atttcagatc ggcggcgccg gccgtccttc attcacgcct cgtcaggcaa 33540
tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat 33600
ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact 33660
atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact 33720
gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc 33780
acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata 33840
tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga 33900
ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca 33960
ctgtgatttg caactgtcct aaccttggat tacatcaaga tctttgttgc catctctgtg 34020
ctgagtataa taaatacaga aattaaaata tactggggct cctatcgcca tcctgtaaac 34080
gccaccgtct tcacccgccc aagcaaacca aggcgaacct tacctggtac ttttaacatc 34140
tctccctctg tgatttacaa cagtttcaac ccagacggag tgagtctacg agagaacctc 34200
tccgagctca gctactccat cagaaaaaac accaccctcc ttacctgccg ggaacgtacg 34260
agtgcgtcac cggccgctgc accacaccta ccgcctgacc gtaaaccaga ctttttccgg 34320
acagacctca ataactctgt ttaccagaac aggaggtgag cttagaaaac ccttagggta 34380
ttaggccaaa ggcgcagcta ctgtggggtt tatgaacaat tcaagcaact ctacgggcta 34440
ttctaattca ggtttctcta gaaatggacg gaattattac agagcagcgc ctgctagaaa 34500
gacgcagggc agcggccgag caacagcgca tgaatcaaga gctccaagac atggttaact 34560
tgcaccagtg caaaaggggt atcttttgtc tggtaaagca ggccaaagtc acctacgaca 34620
gtaataccac cggacaccgc cttagctaca agttgccaac caagcgtcag aaattggtgg 34680
tcatggtggg agaaaagccc attaccataa ctcagcactc ggtagaaacc gaaggctgca 34740
ttcactcacc ttgtcaagga cctgaggatc tctgcaccct tattaagacc ctgtgcggtc 34800
tcaaagatct tattcccttt aactaataaa aaaaaataat aaagcatcac ttacttaaaa 34860
tcagttagca aatttctgtc cagtttattc agcagcacct ccttgccctc ctcccagctc 34920
tggtattgca gcttcctcct ggctgcaaac tttctccaca atctaaatgg aatgtcagtt 34980
tcctcctgtt cctgtccatc cgcacccact atcttcatgt tgttgcagat gaagcgcgca 35040
agaccgtctg aagatacctt caaccccgtg tatccatatg acacggaaac cggtcctcca 35100
actgtgcctt ttcttactcc tccctttgta tcccccaatg ggtttcaaga gagtccccct 35160
ggggtactct ctttgcgcct atccgaacct ctagttacct ccaatggcat gcttgcgctc 35220
aaaatgggca acggcctctc tctggacgag gccggcaacc ttacctccca aaatgtaacc 35280
actgtgagcc cacctctcaa aaaaaccaag tcaaacataa acctggaaat atctgcaccc 35340
ctcacagtta cctcagaagc cctaactgtg gctgccgccg cacctctaat ggtcgcgggc 35400
aacacactca ccatgcaatc acaggccccg ctaaccgtgc acgactccaa acttagcatt 35460
gccacccaag gacccctcac agtgtcagaa ggaaagctag ccctgcaaac atcaggcccc 35520
ctcaccacca ccgatagcag tacccttact atcactgcct caccccctct aactactgcc 35580
actggtagct tgggcattga cttgaaagag cccatttata cacaaaatgg aaaactagga 35640
ctaaagtacg gggctccttt gcatgtaaca gacgacctaa acactttgac cgtagcaact 35700
ggtccaggtg tgactattaa taatacttcc ttgcaaacta aagttactgg agccttgggt 35760
tttgattcac aaggcaatat gcaacttaat gtagcaggag gactaaggat tgattctcaa 35820
aacagacgcc ttatacttga tgttagttat ccgtttgatg ctcaaaacca actaaatcta 35880
agactaggac agggccctct ttttataaac tcagcccaca acttggatat taactacaac 35940
aaaggccttt acttgtttac agcttcaaac aattccaaaa agcttgaggt taacctaagc 36000
actgccaagg ggttgatgtt tgacgctaca gccatagcca ttaatgcagg agatgggctt 36060
gaatttggtt cacctaatgc accaaacaca aatcccctca aaacaaaaat tggccatggc 36120
ctagaatttg attcaaacaa ggctatggtt cctaaactag gaactggcct tagttttgac 36180
agcacaggtg ccattacagt aggaaacaaa aataatgata agctaacttt gtggaccaca 36240
ccagctccat ctcctaactg tagactaaat gcagagaaag atgctaaact cactttggtc 36300
ttaacaaaat gtggcagtca aatacttgct acagtttcag ttttggctgt taaaggcagt 36360
ttggctccaa tatctggaac agttcaaagt gctcatctta ttataagatt tgacgaaaat 36420
ggagtgctac taaacaattc cttcctggac ccagaatatt ggaactttag aaatggagat 36480
cttactgaag gcacagccta tacaaacgct gttggattta tgcctaacct atcagcttat 36540
ccaaaatctc acggtaaaac tgccaaaagt aacattgtca gtcaagttta cttaaacgga 36600
gacaaaacta aacctgtaac actaaccatt acactaaacg gtacacagga aacaggagac 36660
acaactccaa gtgcatactc tatgtcattt tcatgggact ggtctggcca caactacatt 36720
aatgaaatat ttgccacatc ctcttacact ttttcataca ttgcccaaga ataaagaatc 36780
gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcga atcatttttc 36840
attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac 36900
tcacagaacc ctagtattca acctgccacc tccctcccaa cacacagagt acacagtcct 36960
ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt 37020
tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa taaactcccc 37080
gggcagctca cttaagttca tgtcgctgtc cagctgctga gccacaggct gctgtccaac 37140
ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg tagagtcata 37200
atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact gctgccgccg 37260
ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga ttcgcaccgc 37320
ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct cacttaaatc 37380
agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct 37440
gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc acaagcgcag 37500
gtagattaag tggcgacccc tcataaacac gctggacata aacattacct cttttggcat 37560
gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg cgccatccac 37620
caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca gggaaccggg 37680
actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca tgctcgtcat 37740
gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga ttacaagctc 37800
ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg taaatcccac 37860
actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg 37920
cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag gaggtagacg 37980
atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc 38040
aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa 38100
cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg tagtatatcc 38160
actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact ccttcatgcg 38220
ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa cctacacatt 38280
cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg tttttttttt 38340
tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct 38400
ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt aagatgttgc 38460
acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag gctaaaccct 38520
tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa ataattctca 38580
tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc ggccattgta 38640
aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat gattgcaaaa 38700
attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca aaaataccgc 38760
gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct gcacggacca 38820
gcgcggccac ttccccgcca ggaaccttga caaaagaacc cacactgatt atgacacgca 38880
tactcggagc tatgctaacc agcgtagccc cgatgtaagc tttgttgcat gggcggcgat 38940
ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 39000
tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 39060
accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 39120
aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 39180
gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 39240
ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 39300
gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc 39360
gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 39420
aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 39480
gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 39540
aaaacctatt aaaaaaacac cactcgacac ggcaccataa cttcgtatag catacattat 39600
acgaagttat agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat 39660
ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg 39720
cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc 39780
gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag 39840
ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa 39900
actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt attgatgatg 39960
cctccggggt ccactgcaat taataacttc gtatagcata cattatacga agttatttaa 40020
ttaagggcgg ccgcacgggc catcgatggg gatcctaact ttaaataatg ccaattattt 40080
aaagttaatc cgcggagaag cttctcgacc aattctcatg tttgacagct tatcatcgaa 40140
tttctgccat tcatccgctt attatcactt attcaggcgt agcaaccagg cgtttaaggg 40200
caccaataac tgccttaaaa aaattacgcc ccgccctgcc actcatcgca gtactgttgt 40260
aattcattaa gcattctgcc gacatggaag ccatcacaga cggcatgatg aacctgaatc 40320
gccagcggca tcagcacctt gtcgccttgc gtataatatt tgcccatggt gaaaacgggg 40380
gcgaagaagt tgtccatatt ggccacgttt aaatcaaaac tggtgaaact cacccaggga 40440
ttggctgaga cgaaaaacat attctcaata aaccctttag ggaaataggc caggttttca 40500
ccgtaacacg ccacatcttg cgaatatatg tgtagaaact gccggaaatc gtcgtggtat 40560
tcactccaga gcgatgaaaa cgtttcagtt tgctcatgga aaacggtgta acaagggtga 40620
acactatccc atatcaccag ctcaccgtct ttcattgcca tacggaattc cggatgagca 40680
ttcatcaggc gggcaagaat gtgaataaag gccggataaa acttgtgctt atttttcttt 40740
acggtcttta aaaaggccgt aatatccagc tgaacggtct ggttataggt acattgagca 40800
actgactgaa atgcctcaaa atgttcttta cgatgccatt gggatatatc aacggtggta 40860
tatccagtga tttttttctc cattttagct tccttagctc ctgaaaatct cgataactca 40920
aaaaatacgc ccg 40933
<210> 37
<211> 48803
<212> DNA
<213> 人工序列
<220>
<223> pBWH-C5-mChe-Cas9
<400> 37
taactttaaa taatgccaat tatttaaagt taatccgcgg agaagcttct cgaccaattc 60
tcatgtttga cagcttatca tcgaatttct gccattcatc cgcttattat cacttattca 120
ggcgtagcaa ccaggcgttt aagggcacca ataactgcct taaaaaaatt acgccccgcc 180
ctgccactca tcgcagtact gttgtaattc attaagcatt ctgccgacat ggaagccatc 240
acagacggca tgatgaacct gaatcgccag cggcatcagc accttgtcgc cttgcgtata 300
atatttgccc atggtgaaaa cgggggcgaa gaagttgtcc atattggcca cgtttaaatc 360
aaaactggtg aaactcaccc agggattggc tgagacgaaa aacatattct caataaaccc 420
tttagggaaa taggccaggt tttcaccgta acacgccaca tcttgcgaat atatgtgtag 480
aaactgccgg aaatcgtcgt ggtattcact ccagagcgat gaaaacgttt cagtttgctc 540
atggaaaacg gtgtaacaag ggtgaacact atcccatatc accagctcac cgtctttcat 600
tgccatacgg aattccggat gagcattcat caggcgggca agaatgtgaa taaaggccgg 660
ataaaacttg tgcttatttt tctttacggt ctttaaaaag gccgtaatat ccagctgaac 720
ggtctggtta taggtacatt gagcaactga ctgaaatgcc tcaaaatgtt ctttacgatg 780
ccattgggat atatcaacgg tggtatatcc agtgattttt ttctccattt tagcttcctt 840
agctcctgaa aatctcgata actcaaaaaa tacgcccggt agtgatctta tttcattatg 900
gtgaaagttg gaacctctta cgtgccgatc aacgtctcat tttcgccaaa agttggccca 960
gggcttcccg gtatcaacag ggacaccagg atttatttat tctgcgaagt gatcttccgt 1020
cacaggtatt tattcgcgat aagctcatgg agcggcgtaa ccgtcgcaca ggaaggacag 1080
agaaagcgcg gatctgggaa gtgacggaca gaacggtcag gacctggatt ggggaggcgg 1140
ttgccgccgc tgctgctgac ggtgtgacgt tctctgttcc ggtcacacca catacgttcc 1200
gccattccta tgcgatgcac atgctgtatg ccggtatacc gctgaaagtt ctgcaaagcc 1260
tgatgggaca taagtccatc agttcaacgg aagtctacac gaaggttttt gcgctggatg 1320
tggctgcccg gcaccgggtg cagtttgcga tgccggagtc tgatgcggtt gcgatgctga 1380
aacaattatc ctgagaataa atgccttggc ctttatatgg aaatgtggaa ctgagtggat 1440
atgctgtttt tgtctgttaa acagagaagc tggctgttat ccactgagaa gcgaacgaaa 1500
cagtcgggaa aatctcccat tatcgtagag atccgcatta ttaatctcag gagcctgtgt 1560
agcgtttata ggaagtagtg ttctgtcatg atgcctgcaa gcggtaacga aaacgatttg 1620
aatatgcctt caggaacaat agaaatcttc gtgcggtgtt acgttgaagt ggagcggatt 1680
atgtcagcaa tggacagaac aacctaatga acacagaacc atgatgtggt ctgtcctttt 1740
acagccagta ggctcgccgc agtcgagcga cggcgaagcc ctcgagtgag cgaggaagca 1800
ccagggaaca gcacttatat attctgctta cacacgatgc ctgaaaaaac ttcccttggg 1860
gttatccact tatccacggg gatattttta taattatttt ttttatagtt tttagatctt 1920
cttttttaga gcgccttgta ggcctttatc catgctggtt ctagagaagg tgttgtgaca 1980
aattgccctt tcagtgtgac aaatcaccct caaatgacag tcctgtctgt gacaaattgc 2040
ccttaaccct gtgacaaatt gccctcagaa gaagctgttt tttcacaaag ttatccctgc 2100
ttattgactc ttttttattt agtgtgacaa tctaaaaact tgtcacactt cacatggatc 2160
tgtcatggcg gaaacagcgg ttatcaatca caagaaacgt aaaaatagcc cgcgaatcgt 2220
ccagtcaaac gacctcactg aggcggcata tagtctctcc cgggatcaaa aacgtatgct 2280
gtatctgttc gttgaccaga tcagaaaatc tgatggcacc ctacaggaac atgacggtat 2340
ctgcgagatc catgttgcta aatatgctga aatattcgga ttgacctctg cggaagccag 2400
taaggatata cggcaggcat tgaagagttt cgcggggaag gaagtggttt tttatcgccc 2460
tgaagaggat gccggcgatg aaaaaggcta tgaatctttt ccttggttta tcaaacgtgc 2520
gcacagtcca tccagagggc tttacagtgt acatatcaac ccatatctca ttcccttctt 2580
tatcgggtta cagaaccggt ttacgcagtt tcggcttagt gaaacaaaag aaatcaccaa 2640
tccgtatgcc atgcgtttat acgaatccct gtgtcagtat cgtaagccgg atggctcagg 2700
catcgtctct ctgaaaatcg actggatcat agagcgttac cagctgcctc aaagttacca 2760
gcgtatgcct gacttccgcc gccgcttcct gcaggtctgt gttaatgaga tcaacagcag 2820
aactccaatg cgcctctcat acattgagaa aaagaaaggc cgccagacga ctcatatcgt 2880
attttccttc cgcgatatca cttccatgac gacaggatag tctgagggtt atctgtcaca 2940
gatttgaggg tggttcgtca catttgttct gacctactga gggtaatttg tcacagtttt 3000
gctgtttcct tcagcctgca tggattttct catacttttt gaactgtaat ttttaaggaa 3060
gccaaatttg agggcagttt gtcacagttg atttccttct ctttcccttc gtcatgtgac 3120
ctgatatcgg gggttagttc gtcatcattg atgagggttg attatcacag tttattactc 3180
tgaattggct atccgcgtgt gtacctctac ctggagtttt tcccacggtg gatatttctt 3240
cttgcgctga gcgtaagagc tatctgacag aacagttctt ctttgcttcc tcgccagttc 3300
gctcgctatg ctcggttaca cggctgcggc gagcgctagt gataataagt gactgaggta 3360
tgtgctcttc ttatctcctt ttgtagtgtt gctcttattt taaacaactt tgcggttttt 3420
tgatgacttt gcgattttgt tgttgctttg cagtaaattg caagatttaa taaaaaaacg 3480
caaagcaatg attaaaggat gttcagaatg aaactcatgg aaacacttaa ccagtgcata 3540
aacgctggtc atgaaatgac gaaggctatc gccattgcac agtttaatga tgacagcccg 3600
gaagcgagga aaataacccg gcgctggaga ataggtgaag cagcggattt agttggggtt 3660
tcttctcagg ctatcagaga tgccgagaaa gcagggcgac taccgcaccc ggatatggaa 3720
attcgaggac gggttgagca acgtgttggt tatacaattg aacaaattaa tcatatgcgt 3780
gatgtgtttg gtacgcgatt gcgacgtgct gaagacgtat ttccaccggt gatcggggtt 3840
gctgcccata aaggtggcgt ttacaaaacc tcagtttctg ttcatcttgc tcaggatctg 3900
gctctgaagg ggctacgtgt tttgctcgtg gaaggtaacg acccccaggg aacagcctca 3960
atgtatcacg gatgggtacc agatcttcat attcatgcag aagacactct cctgcctttc 4020
tatcttgggg aaaaggacga tgtcacttat gcaataaagc ccacttgctg gccggggctt 4080
gacattattc cttcctgtct ggctctgcac cgtattgaaa ctgagttaat gggcaaattt 4140
gatgaaggta aactgcccac cgatccacac ctgatgctcc gactggccat tgaaactgtt 4200
gctcatgact atgatgtcat agttattgac agcgcgccta acctgggtat cggcacgatt 4260
aatgtcgtat gtgctgctga tgtgctgatt gttcccacgc ctgctgagtt gtttgactac 4320
acctccgcac tgcagttttt cgatatgctt cgtgatctgc tcaagaacgt tgatcttaaa 4380
gggttcgagc ctgatgtacg tattttgctt accaaataca gcaatagtaa tggctctcag 4440
tccccgtgga tggaggagca aattcgggat gcctggggaa gcatggttct aaaaaatgtt 4500
gtacgtgaaa cggatgaagt tggtaaaggt cagatccgga tgagaactgt ttttgaacag 4560
gccattgatc aacgctcttc aactggtgcc tggagaaatg ctctttctat ttgggaacct 4620
gtctgcaatg aaattttcga tcgtctgatt aaaccacgct gggagattag ataatgaagc 4680
gtgcgcctgt tattccaaaa catacgctca atactcaacc ggttgaagat acttcgttat 4740
cgacaccagc tgccccgatg gtggattcgt taattgcgcg cgtaggagta atggctcgcg 4800
gtaatgccat tactttgcct gtatgtggtc gggatgtgaa gtttactctt gaagtgctcc 4860
ggggtgatag tgttgagaag acctctcggg tatggtcagg taatgaacgt gaccaggagc 4920
tgcttactga ggacgcactg gatgatctca tcccttcttt tctactgact ggtcaacaga 4980
caccggcgtt cggtcgaaga gtatctggtg tcatagaaat tgccgatggg agtcgccgtc 5040
gtaaagctgc tgcacttacc gaaagtgatt atcgtgttct ggttggcgag ctggatgatg 5100
agcagatggc tgcattatcc agattgggta acgattatcg cccaacaagt gcttatgaac 5160
gtggtcagcg ttatgcaagc cgattgcaga atgaatttgc tggaaatatt tctgcgctgg 5220
ctgatgcgga aaatatttca cgtaagatta ttacccgctg tatcaacacc gccaaattgc 5280
ctaaatcagt tgttgctctt ttttctcacc ccggtgaact atctgcccgg tcaggtgatg 5340
cacttcaaaa agcctttaca gataaagagg aattacttaa gcagcaggca tctaaccttc 5400
atgagcagaa aaaagctggg gtgatatttg aagctgaaga agttatcact cttttaactt 5460
ctgtgcttaa aacgtcatct gcatcaagaa ctagtttaag ctcacgacat cagtttgctc 5520
ctggagcgac agtattgtat aagggcgata aaatggtgct taacctggac aggtctcgtg 5580
ttccaactga gtgtatagag aaaattgagg ccattcttaa ggaacttgaa aagccagcac 5640
cctgatgcga ccacgtttta gtctacgttt atctgtcttt acttaatgtc ctttgttaca 5700
ggccagaaag cataactggc ctgaatattc tctctgggcc cactgttcca cttgtatcgt 5760
cggtctgata atcagactgg gaccacggtc ccactcgtat cgtcggtctg attattagtc 5820
tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 5880
tcgtatcgtc ggtctgataa tcagactggg accacggtcc cactcgtatc gtcggtctga 5940
ttattagtct gggaccatgg tcccactcgt atcgtcggtc tgattattag tctgggacca 6000
cggtcccact cgtatcgtcg gtctgattat tagtctggaa ccacggtccc actcgtatcg 6060
tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 6120
ctgggaccac gatcccactc gtgttgtcgg tctgattatc ggtctgggac cacggtccca 6180
cttgtattgt cgatcagact atcagcgtga gactacgatt ccatcaatgc ctgtcaaggg 6240
caagtattga catgtcgtcg taacctgtag aacggagtaa cctcggtgtg cggttgtatg 6300
cctgctgtgg attgctgctg tgtcctgctt atccacaaca ttttgcgcac ggttatgtgg 6360
acaaaatacc tggttaccca ggccgtgccg gcacgttaac cgggctgcat ccgatgcaag 6420
tgtgtcgctg tcgagttttc gggggagtcc agggttttcc cagtcacgac gttgtaaaac 6480
gacggccagt gaattcgagc tcggtacccg gggatcttga agttcctatt ctctagaaag 6540
tataggaact tcaattccca tgtcagccgt taagtgttcc tgtgtcactc aaaattgctt 6600
tgagaggctc taagggcttc tcagtgcgtt acatccctgg cttgttgtcc acaaccgtta 6660
aaccttaaaa gctttaaaag ccttatatat tctttttttt cttataaaac ttaaaacctt 6720
agaggctatt taagttgctg atttatatta attttattgt tcaaacatga gagcttagta 6780
cgtgaaacat gagagcttag tacgttagcc atgagagctt agtacgttag ccatgagggt 6840
ttagttcgtt aaacatgaga gcttagtacg ttaaacatga gagcttagta cgtgaaacat 6900
gagagcttag tacgtactat caacaggttg aactgctgat cttcagatcc tctacgccgg 6960
acgcatcgtg gccttaatta acatatggat ttattcaaca aagccacgtt gtgtctcaaa 7020
atctctgatg ttacattgca caagataaaa atatatcatc atgaacaata aaactgtctg 7080
cttacataaa cagtaataca aggggtgtta tgagccatat tcaacgggaa acgtcttgct 7140
cgaggccgcg attaaattcc aacatggatg ctgatttata tgggtataaa tgggctcgcg 7200
ataatgtcgg gcaatcaggt gcgacaatct atcgattgta tgggaagccc gatgcgccag 7260
agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat gagatggtca 7320
gactaaactg gctgacggaa tttatgcctc ttccgaccat caagcatttt atccgtactc 7380
ctgatgatgc atggttactc accactgcga tccccgggaa aacagcattc caggtattag 7440
aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt 7500
tgcattcgat tcctgtttgt aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc 7560
aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat gacgagcgta 7620
atggctggcc tgttgaacaa gtctggaaag aaatgcataa gcttttgcca ttctcaccgg 7680
attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac gaggggaaat 7740
taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag gatcttgcca 7800
tcctatggaa ctgcctcggt gagttttctc cttcattaca gaaacggctt tttcaaaaat 7860
atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc gatgagtttt 7920
tctaatcaga attggttaat tggttgtaac actgggcatg ctaattgcag tggaccccgg 7980
aggcatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg 8040
agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag 8100
tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt 8160
ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg 8220
tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga 8280
ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taataatagt aatcaattac 8340
ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg 8400
cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc 8460
catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac 8520
tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa 8580
tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac 8640
ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta 8700
catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga 8760
cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa 8820
ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag 8880
agctggttta gtgaaccgtc agatccgcta gcgctaccgg actcagatct cgagctcaag 8940
cttcgaattc tgcagtcgac ggtaccgagc tcggatcccg ccaccatggt gagcaagggc 9000
gaggaggata acatggccat catcaaggag ttcatgcgct tcaaggtgca catggagggc 9060
tccgtgaacg gccacgagtt cgagatcgag ggcgagggcg agggccgccc ctacgagggc 9120
acccagaccg ccaagctgaa ggtgaccaag ggtggccccc tgcccttcgc ctgggacatc 9180
ctgtcccctc agttcatgta cggctccaag gcctacgtga agcaccccgc cgacatcccc 9240
gactacttga agctgtcctt ccccgagggc ttcaagtggg agcgcgtgat gaacttcgag 9300
gacggcggcg tggtgaccgt gacccaggac tcctccctgc aggacggcga gttcatctac 9360
aaggtgaagc tgcgcggcac caacttcccc tccgacggcc ccgtaatgca gaagaagacc 9420
atgggctggg aggcctcctc cgagcggatg taccccgagg acggcgccct gaagggcgag 9480
atcaagcaga ggctgaagct gaaggacggc ggccactacg acgctgaggt caagaccacc 9540
tacaaggcca agaagcccgt gcagctgccc ggcgcctaca acgtcaacat caagttggac 9600
atcacctccc acaacgagga ctacaccatc gtggaacagt acgaacgcgc cgagggccgc 9660
cactccaccg gcggcatgga cgagctgtac aagtaagaat tctgcagata tccagcacag 9720
tggcggccgc gactctagat cataatcagc cataccacat ttgtagaggt tttacttgct 9780
ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc aattgttgtt 9840
gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 9900
acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta 9960
tcttaaatcg aattcaagct tgtcgactcg aagatctgag ctcacgcgtg aagttcctat 10020
tccgaagttc ctattctcta gaaagtatag gaacttcaga gcgcttttga agctggggtg 10080
ggcgaagaac tccagcatga gatccccaga gcgcttttga agctgcgttt aaacgcgata 10140
tcccgggagc tcccgatatc gcgtttaaac gcagcttggc gtaatcatgg tcatagctgt 10200
ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc ggaagactga 10260
aatgtgtggg cgtggcttaa gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt 10320
ttgtatctgt tttgcagcag ccgccgccgc catgagcacc aactcgtttg atggaagcat 10380
tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 10440
gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 10500
gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 10560
caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 10620
ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 10680
gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 10740
cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 10800
ttggatttgg atcaagcaag tgtcttgctg tctttattta ggggttttgc gcgcgcggta 10860
ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt attttttcca ggacgtggta 10920
aaggtgactc tggatgttca gatacatggg cataagcccg tctctggggt ggaggtagca 10980
ccactgcaga gcttcatgct gcggggtggt gttgtagatg atccagtcgt agcaggagcg 11040
ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg attgccaggg gcaggccctt 11100
ggtgtaagtg tttacaaagc ggttaagctg ggatgggtgc atacgtgggg atatgagatg 11160
catcttggac tgtattttta ggttggctat gttcccagcc atatccctcc ggggattcat 11220
gttgtgcaga accaccagca cagtgtatcc ggtgcacttg ggaaatttgt catgtagctt 11280
agaaggaaat gcgtggaaga acttggagac gcccttgtga cctccaagat tttccatgca 11340
ttcgtccata atgatggcaa tgggcccacg ggcggcggcc tgggcgaaga tatttctggg 11400
atcactaacg tcatagttgt gttccaggat gagatcgtca taggccattt ttacaaagcg 11460
cgggcggagg gtgccagact gcggtataat ggttccatcc ggcccagggg cgtagttacc 11520
ctcacagatt tgcatttccc acgctttgag ttcagatggg gggatcatgt ctacctgcgg 11580
ggcgatgaag aaaacggttt ccggggtagg ggagatcagc tgggaagaaa gcaggttcct 11640
gagcagctgc gacttaccgc agccggtggg cccgtaaatc acacctatta ccgggtgcaa 11700
ctggtagtta agagagctgc agctgccgtc atccctgagc aggggggcca cttcgttaag 11760
catgtccctg actcgcatgt tttccctgac caaatccgcc agaaggcgct cgccgcccag 11820
cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt ttgagaccgt ccgccgtagg 11880
catgcttttg agcgtttgac caagcagttc caggcggtcc cacagctcgg tcacctgctc 11940
tacggcatct cgatccagca tatctcctcg tttcgcgggt tggggcggct ttcgctgtac 12000
ggcagtagtc ggtgctcgtc cagacgggcc agggtcatgt ctttccacgg gcgcagggtc 12060
ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc cgggctgcgc gctggccagg 12120
gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc ggtcttcgcc ctgcgcgtcg 12180
gccaggtagc atttgaccat ggtgtcatag tccagcccct ccgcggcgtg gcccttggcg 12240
cgcagcttgc ccttggagga ggcgccgcac gaggggcagt gcagactttt gagggcgtag 12300
agcttgggcg cgagaaatac cgattccggg gagtaggcat ccgcgccgca ggccccgcag 12360
acggtctcgc attccacgag ccaggtgagc tctggccgtt cggggtcaaa aaccaggttt 12420
cccccatgct ttttgatgcg tttcttacct ctggtttcca tgagccggtg tccacgctcg 12480
gtgacgaaaa ggctgtccgt gtccccgtat acagacttga gaggcctgtc ctcgagcggt 12540
gttccgcggt cctcctcgta tagaaactcg gaccactctg agacaaaggc tcgcgtccag 12600
gccagcacga aggaggctaa gtgggagggg tagcggtcgt tgtccactag ggggtccact 12660
cgctccaggg tgtgaagaca catgtcgccc tcttcggcat caaggaaggt gattggtttg 12720
taggtgtagg ccacgtgacc gggtgttcct gaaggggggc tataaaaggg ggtgggggcg 12780
cgttcgtcct cactctcttc cgcatcgctg tctgcgaggg ccagctgttg gggtgagtac 12840
tccctctgaa aagcgggcat gacttctgcg ctaagattgt cagtttccaa aaacgaggag 12900
gatttgatat tcacctggcc cgcggtgatg cctttgaggg tggccgcatc catctggtca 12960
gaaaagacaa tctttttgtt gtcaagcttg gtggcaaacg acccgtagag ggcgttggac 13020
agcaacttgg cgatggagcg cagggtttgg tttttgtcgc gatcggcgcg ctccttggcc 13080
gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc attcgggaaa gacggtggtg 13140
cgctcgtcgg gcaccaggtg cacgcgccaa ccgcggttgt gcagggtgac aaggtcaacg 13200
ctggtggcta cctctccgcg taggcgctcg ttggtccagc agaggcggcc gcccttgcgc 13260
gagcagaatg gcggtagggg gtctagctgc gtctcgtccg gggggtctgc gtccacggta 13320
aagaccccgg gcagcaggcg cgcgtcgaag tagtctatct tgcatccttg caagtctagc 13380
gcctgctgcc atgcgcgggc ggcaagcgcg cgctcgtatg ggttgagtgg gggaccccat 13440
ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa tgtcgtaaac gtagaggggc 13500
tctctgagta ttccaagata tgtagggtag catcttccac cgcggatgct ggcgcgcacg 13560
taatcgtata gttcgtgcga gggagcgagg aggtcgggac cgaggttgct acgggcgggc 13620
tgctctgctc ggaagactat ctgcctgaag atggcatgtg agttggatga tatggttgga 13680
cgctggaaga cgttgaagct ggcgtctgtg agacctaccg cgtcacgcac gaaggaggcg 13740
taggagtcgc gcagcttgtt gaccagctcg gcggtgacct gcacgtctag ggcgcagtag 13800
tccagggttt ccttgatgat gtcatactta tcctgtccct tttttttcca cagctcgcgg 13860
ttgaggacaa actcttcgcg gtctttccag tactcttgga tcggaaaccc gtcggcctcc 13920
gaacggtaag agcctagcat gtagaactgg ttgacggcct ggtaggcgca gcatcccttt 13980
tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg aggtgtgggt gagcgcaaag 14040
gtgtccctga ccatgacttt gaggtactgg tatttgaagt cagtgtcgtc gcatccgccc 14100
tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg gatttggcag ggcgaaggtg 14160
acatcgttga agagtatctt tcccgcgcga ggcataaagt tgcgtgtgat gcggaagggt 14220
cccggcacct cggaacggtt gttaattacc tgggcggcga gcacgatctc gtcaaagccg 14280
ttgatgttgt ggcccacaat gtaaagttcc aagaagcgcg ggatgccctt gatggaaggc 14340
aattttttaa gttcctcgta ggtgagctct tcaggggagc tgagcccgtg ctctgaaagg 14400
gcccagtctg caagatgagg gttggaagcg acgaatgagc tccacaggtc acgggccatt 14460
agcatttgca ggtggtcgcg aaaggtccta aactggcgac ctatggccat tttttctggg 14520
gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt cccatccaag gttcgcggct 14580
aggtctcgcg cggcagtcac tagaggctca tctccgccga acttcatgac cagcatgaag 14640
ggcacgagct gcttcccaaa ggcccccatc caagtatagg tctctacatc gtaggtgaca 14700
aagagacgct cggtgcgagg atgcgagccg atcgggaaga actggatctc ccgccaccaa 14760
ttggaggagt ggctattgat gtggtgaaag tagaagtccc tgcgacgggc cgaacactcg 14820
tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt gcacgggctg tacatcctgc 14880
acgaggttga cctgacgacc gcgcacaagg aagcagagtg ggaatttgag cccctcgcct 14940
ggcgggtttg gctggtggtc ttctacttcg gctgcttgtc cttgaccgtc tggctgctcg 15000
aggggagtta cggtggatcg gaccaccacg ccgcgcgagc ccaaagtcca gatgtccgcg 15060
cgcggcggtc ggagcttgat gacaacatcg cgcagatggg agctgtccat ggtctggagc 15120
tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta cctcgcatag acgggtcagg 15180
gcgcgggcta gatccaggtg atacctaatt tccaggggct ggttggtggc ggcgtcgatg 15240
gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac cgcgcggcgg gcggtgggcc 15300
gcgggggtgt ccttggatga tgcatctaaa agcggtgacg cgggcgagcc cccggaggta 15360
gggggggctc cggacccgcc gggagagggg gcaggggcac gtcggcgccg cgcgcgggca 15420
ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac gacgcggcgg ttgatctcct 15480
gaatctggcg cctctgcgtg aagacgacgg gcccggtgag cttgagcctg aaagagagtt 15540
cgacagaatc aatttcggtg tcgttgacgg cggcctggcg caaaatctcc tgcacgtctc 15600
ctgagttgtc ttgataggcg atctcggcca tgaactgctc gatctcttcc tcctggagat 15660
ctccgcgtcc ggctcgctcc acggtggcgg cgaggtcgtt ggaaatgcgg gccatgagct 15720
gcgagaaggc gttgaggcct ccctcgttcc agacgcggct gtagaccacg cccccttcgg 15780
catcgcgggc gcgcatgacc acctgcgcga gattgagctc cacgtgccgg gcgaagacgg 15840
cgtagtttcg caggcgctga aagaggtagt tgagggtggt ggcggtgtgt tctgccacga 15900
agaagtacat aacccagcgt cgcaacgtgg attcgttgat atcccccaag gcctcaaggc 15960
gctccatggc ctcgtagaag tccacggcga agttgaaaaa ctgggagttg cgcgccgaca 16020
cggttaactc ctcctccaga agacggatga gctcggcgac agtgtcgcgc acctcgcgct 16080
caaaggctac aggggcctct tcttcttctt caatctcctc ttccataagg gcctcccctt 16140
cttcttcttc tggcggcggt gggggagggg ggacacggcg gcgacgacgg cgcaccggga 16200
ggcggtcgac aaagcgctcg atcatctccc cgcggcgacg gcgcatggtc tcggtgacgg 16260
cgcggccgtt ctcgcggggg cgcagttgga agacgccgcc cgtcatgtcc cggttatggg 16320
ttggcggggg gctgccatgc ggcagggata cggcgctaac gatgcatctc aacaattgtt 16380
gtgtaggtac tccgccgccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc 16440
tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg 16500
gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt 16560
aggcggtctt gagacggcgg atggtcgaca gaagcaccat gtccttgggt ccggcctgct 16620
gaatgcgcag gcggtcggcc atgccccagg cttcgttttg acatcggcgc aggtctttgt 16680
agtagtcttg catgagcctt tctaccggca cttcttcttc tccttcctct tgtcctgcat 16740
ctcttgcatc tatcgctgcg gcggcggcgg agtttggccg taggtggcgc cctcttcctc 16800
ccatgcgtgt gaccccgaag cccctcatcg gctgaagcag ggctaggtcg gcgacaacgc 16860
gctcggctaa tatggcctgc tgcacctgcg tgagggtaga ctggaagtca tccatgtcca 16920
caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca gttggccata acggaccagt 16980
taacggtctg gtgacccggc tgcgagagct cggtgtacct gagacgcgag taagccctcg 17040
agtcaaatac gtagtcgttg caagtccgca ccaggtactg gtatcccacc aaaaagtgcg 17100
gcggcggctg gcggtagagg ggccagcgta gggtggccgg ggctccgggg gcgagatctt 17160
ccaacataag gcgatgatat ccgtagatgt acctggacat ccaggtgatg ccggcggcgg 17220
tggtggaggc gcgcggaaag tcgcggacgc ggttccagat gttgcgcagc ggcaaaaagt 17280
gctccatggt cgggacgctc tggccggtca ggcgcgcgca atcgttgacg ctctagaccg 17340
tgcaaaagga gagcctgtaa gcgggcactc ttccgtggtc tggtggataa attcgcaagg 17400
gtatcatggc ggacgaccgg ggttcgagcc ccgtatccgg ccgtccgccg tgatccatgc 17460
ggttaccgcc cgcgtgtcga acccaggtgt gcgacgtcag acaacggggg agtgctcctt 17520
ttggcttcct tccaggcgcg gcggctgctg cgctagcttt tttggccact ggccgcgcgc 17580
agcgtaagcg gttaggctgg aaagcgaaag cattaagtgg ctcgctccct gtagccggag 17640
ggttattttc caagggttga gtcgcgggac ccccggttcg agtctcggac cggccggact 17700
gcggcgaacg ggggtttgcc tccccgtcat gcaagacccc gcttgcaaat tcctccggaa 17760
acagggacga gccccttttt tgcttttccc agatgcatcc ggtgctgcgg cagatgcgcc 17820
cccctcctca gcagcggcaa gagcaagagc agcggcagac atgcagggca ccctcccctc 17880
ctcctaccgc gtcaggaggg gcgacatccg cggttgacgc ggcagcagat ggtgattacg 17940
aacccccgcg gcgccgggcc cggcactacc tggacttgga ggagggcgag ggcctggcgc 18000
ggctaggagc gccctctcct gagcggtacc caagggtgca gctgaagcgt gatacgcgtg 18060
aggcgtacgt gccgcggcag aacctgtttc gcgaccgcga gggagaggag cccgaggaga 18120
tgcgggatcg aaagttccac gcagggcgcg agctgcggca tggcctgaat cgcgagcggt 18180
tgctgcgcga ggaggacttt gagcccgacg cgcgaaccgg gattagtccc gcgcgcgcac 18240
acgtggcggc cgccgacctg gtaaccgcat acgagcagac ggtgaaccag gagattaact 18300
ttcaaaaaag ctttaacaac cacgtgcgta cgcttgtggc gcgcgaggag gtggctatag 18360
gactgatgca tctgtgggac tttgtaagcg cgctggagca aaacccaaat agcaagccgc 18420
tcatggcgca gctgttcctt atagtgcagc acagcaggga caacgaggca ttcagggatg 18480
cgctgctaaa catagtagag cccgagggcc gctggctgct cgatttgata aacatcctgc 18540
agagcatagt ggtgcaggag cgcagcttga gcctggctga caaggtggcc gccatcaact 18600
attccatgct tagcctgggc aagttttacg cccgcaagat ataccatacc ccttacgttc 18660
ccatagacaa ggaggtaaag atcgaggggt tctacatgcg catggcgctg aaggtgctta 18720
ccttgagcga cgacctgggc gtttatcgca acgagcgcat ccacaaggcc gtgagcgtga 18780
gccggcggcg cgagctcagc gaccgcgagc tgatgcacag cctgcaaagg gccctggctg 18840
gcacgggcag cggcgataga gaggccgagt cctactttga cgcgggcgct gacctgcgct 18900
gggccccaag ccgacgcgcc ctggaggcag ctggggccgg acctgggctg gcggtggcac 18960
ccgcgcgcgc tggcaacgtc ggcggcgtgg aggaatatga cgaggacgat gagtacgagc 19020
cagaggacgg cgagtactaa gcggtgatgt ttctgatcag atgatgcaag acgcaacgga 19080
cccggcggtg cgggcggcgc tgcagagcca gccgtccggc cttaactcca cggacgactg 19140
gcgccaggtc atggaccgca tcatgtcgct gactgcgcgc aatcctgacg cgttccggca 19200
gcagccgcag gccaaccggc tctccgcaat tctggaagcg gtggtcccgg cgcgcgcaaa 19260
ccccacgcac gagaaggtgc tggcgatcgt aaacgcgctg gccgaaaaca gggccatccg 19320
gcccgacgag gccggcctgg tctacgacgc gctgcttcag cgcgtggctc gttacaacag 19380
cggcaacgtg cagaccaacc tggaccggct ggtgggggat gtgcgcgagg ccgtggcgca 19440
gcgtgagcgc gcgcagcagc agggcaacct gggctccatg gttgcactaa acgccttcct 19500
gagtacacag cccgccaacg tgccgcgggg acaggaggac tacaccaact ttgtgagcgc 19560
actgcggcta atggtgactg agacaccgca aagtgaggtg taccagtctg ggccagacta 19620
ttttttccag accagtagac aaggcctgca gaccgtaaac ctgagccagg ctttcaaaaa 19680
cttgcagggg ctgtgggggg tgcgggctcc cacaggcgac cgcgcgaccg tgtctagctt 19740
gctgacgccc aactcgcgcc tgttgctgct gctaatagcg cccttcacgg acagtggcag 19800
cgtgtcccgg gacacatacc taggtcactt gctgacactg taccgcgagg ccataggtca 19860
ggcgcatgtg gacgagcata ctttccagga gattacaagt gtcagccgcg cgctggggca 19920
ggaggacacg ggcagcctgg aggcaaccct aaactacctg ctgaccaacc ggcggcagaa 19980
gatcccctcg ttgcacagtt taaacagcga ggaggagcgc attttgcgct acgtgcagca 20040
gagcgtgagc cttaacctga tgcgcgacgg ggtaacgccc agcgtggcgc tggacatgac 20100
cgcgcgcaac atggaaccgg gcatgtatgc ctcaaaccgg ccgtttatca accgcctaat 20160
ggactacttg catcgcgcgg ccgccgtgaa ccccgagtat ttcaccaatg ccatcttgaa 20220
cccgcactgg ctaccgcccc ctggtttcta caccggggga ttcgaggtgc ccgagggtaa 20280
cgatggattc ctctgggacg acatagacga cagcgtgttt tccccgcaac cgcagaccct 20340
gctagagttg caacagcgcg agcaggcaga ggcggcgctg cgaaaggaaa gcttccgcag 20400
gccaagcagc ttgtccgatc taggcgctgc ggccccgcgg tcagatgcta gtagcccatt 20460
tccaagcttg atagggtctc ttaccagcac tcgcaccacc cgcccgcgcc tgctgggcga 20520
ggaggagtac ctaaacaact cgctgctgca gccgcagcgc gaaaaaaacc tgcctccggc 20580
atttcccaac aacgggatag agagcctagt ggacaagatg agtagatgga agacgtacgc 20640
gcaggagcac agggacgtgc caggcccgcg cccgcccacc cgtcgtcaaa ggcacgaccg 20700
tcagcggggt ctggtgtggg aggacgatga ctcggcagac gacagcagcg tcctggattt 20760
gggagggagt ggcaacccgt ttgcgcacct tcgccccagg ctggggagaa tgttttaaaa 20820
aaaaaaaagc atgatgcaaa ataaaaaact caccaaggcc atggcaccga gcgttggttt 20880
tcttgtattc cccttagtat gcggcgcgcg gcgatgtatg aggaaggtcc tcctccctcc 20940
tacgagagtg tggtgagcgc ggcgccagtg gcggcggcgc tgggttctcc cttcgatgct 21000
cccctggacc cgccgtttgt gcctccgcgg tacctgcggc ctaccggggg gagaaacagc 21060
atccgttact ctgagttggc acccctattc gacaccaccc gtgtgtacct ggtggacaac 21120
aagtcaacgg atgtggcatc cctgaactac cagaacgacc acagcaactt tctgaccacg 21180
gtcattcaaa acaatgacta cagcccgggg gaggcaagca cacagaccat caatcttgac 21240
gaccggtcgc actggggcgg cgacctgaaa accatcctgc ataccaacat gccaaatgtg 21300
aacgagttca tgtttaccaa taagtttaag gcgcgggtga tggtgtcgcg cttgcctact 21360
aaggacaatc aggtggagct gaaatacgag tgggtggagt tcacgctgcc cgagggcaac 21420
tactccgaga ccatgaccat agaccttatg aacaacgcga tcgtggagca ctacttgaaa 21480
gtgggcagac agaacggggt tctggaaagc gacatcgggg taaagtttga cacccgcaac 21540
ttcagactgg ggtttgaccc cgtcactggt cttgtcatgc ctggggtata tacaaacgaa 21600
gccttccatc cagacatcat tttgctgcca ggatgcgggg tggacttcac ccacagccgc 21660
ctgagcaact tgttgggcat ccgcaagcgg caacccttcc aggagggctt taggatcacc 21720
tacgatgatc tggagggtgg taacattccc gcactgttgg atgtggacgc ctaccaggcg 21780
agcttgaaag atgacaccga acagggcggg ggtggcgcag gcggcagcaa cagcagtggc 21840
agcggcgcgg aagagaactc caacgcggca gccgcggcaa tgcagccggt ggaggacatg 21900
aacgatcatg ccattcgcgg cgacaccttt gccacacggg ctgaggagaa gcgcgctgag 21960
gccgaagcag cggccgaagc tgccgccccc gctgcgcaac ccgaggtcga gaagcctcag 22020
aagaaaccgg tgatcaaacc cctgacagag gacagcaaga aacgcagtta caacctaata 22080
agcaatgaca gcaccttcac ccagtaccgc agctggtacc ttgcatacaa ctacggcgac 22140
cctcagaccg gaatccgctc atggaccctg ctttgcactc ctgacgtaac ctgcggctcg 22200
gagcaggtct actggtcgtt gccagacatg atgcaagacc ccgtgacctt ccgctccacg 22260
cgccagatca gcaactttcc ggtggtgggc gccgagctgt tgcccgtgca ctccaagagc 22320
ttctacaacg accaggccgt ctactcccaa ctcatccgcc agtttacctc tctgacccac 22380
gtgttcaatc gctttcccga gaaccagatt ttggcgcgcc cgccagcccc caccatcacc 22440
accgtcagtg aaaacgttcc tgctctcaca gatcacggga cgctaccgct gcgcaacagc 22500
atcggaggag tccagcgagt gaccattact gacgccagac gccgcacctg cccctacgtt 22560
tacaaggccc tgggcatagt ctcgccgcgc gtcctatcga gccgcacttt ttgagcaagc 22620
atgtccatcc ttatatcgcc cagcaataac acaggctggg gcctgcgctt cccaagcaag 22680
atgtttggcg gggccaagaa gcgctccgac caacacccag tgcgcgtgcg cgggcactac 22740
cgcgcgccct ggggcgcgca caaacgcggc cgcactgggc gcaccaccgt cgatgacgcc 22800
atcgacgcgg tggtggagga ggcgcgcaac tacacgccca cgccgccacc agtgtccaca 22860
gtggacgcgg ccattcagac cgtggtgcgc ggagcccggc gctatgctaa aatgaagaga 22920
cggcggaggc gcgtagcacg tcgccaccgc cgccgacccg gcactgccgc ccaacgcgcg 22980
gcggcggccc tgcttaaccg cgcacgtcgc accggccgac gggcggccat gcgggccgct 23040
cgaaggctgg ccgcgggtat tgtcactgtg ccccccaggt ccaggcgacg agcggccgcc 23100
gcagcagccg cggccattag tgctatgact cagggtcgca ggggcaacgt gtattgggtg 23160
cgcgactcgg ttagcggcct gcgcgtgccc gtgcgcaccc gccccccgcg caactagatt 23220
gcaagaaaaa actacttaga ctcgtactgt tgtatgtatc cagcggcggc ggcgcgcaac 23280
gaagctatgt ccaagcgcaa aatcaaagaa gagatgctcc aggtcatcgc gccggagatc 23340
tatggccccc cgaagaagga agagcaggat tacaagcccc gaaagctaaa gcgggtcaaa 23400
aagaaaaaga aagatgatga tgatgaactt gacgacgagg tggaactgct gcacgctacc 23460
gcgcccaggc gacgggtaca gtggaaaggt cgacgcgtaa aacgtgtttt gcgacccggc 23520
accaccgtag tctttacgcc cggtgagcgc tccacccgca cctacaagcg cgtgtatgat 23580
gaggtgtacg gcgacgagga cctgcttgag caggccaacg agcgcctcgg ggagtttgcc 23640
tacggaaagc ggcataagga catgctggcg ttgccgctgg acgagggcaa cccaacacct 23700
agcctaaagc ccgtaacact gcagcaggtg ctgcccgcgc ttgcaccgtc cgaagaaaag 23760
cgcggcctaa agcgcgagtc tggtgacttg gcacccaccg tgcagctgat ggtacccaag 23820
cgccagcgac tggaagatgt cttggaaaaa atgaccgtgg aacctgggct ggagcccgag 23880
gtccgcgtgc ggccaatcaa gcaggtggcg ccgggactgg gcgtgcagac cgtggacgtt 23940
cagataccca ctaccagtag caccagtatt gccaccgcca cagagggcat ggagacacaa 24000
acgtccccgg ttgcctcagc ggtggcggat gccgcggtgc aggcggtcgc tgcggccgcg 24060
tccaagacct ctacggaggt gcaaacggac ccgtggatgt ttcgcgtttc agccccccgg 24120
cgcccgcgcg gttcgaggaa gtacggcgcc gccagcgcgc tactgcccga atatgcccta 24180
catccttcca ttgcgcctac ccccggctat cgtggctaca cctaccgccc cagaagacga 24240
gcaactaccc gacgccgaac caccactgga acccgccgcc gccgtcgccg tcgccagccc 24300
gtgctggccc cgatttccgt gcgcagggtg gctcgcgaag gaggcaggac cctggtgctg 24360
ccaacagcgc gctaccaccc cagcatcgtt taaaagccgg tctttgtggt tcttgcagat 24420
atggccctca cctgccgcct ccgtttcccg gtgccgggat tccgaggaag aatgcaccgt 24480
aggaggggca tggccggcca cggcctgacg ggcggcatgc gtcgtgcgca ccaccggcgg 24540
cggcgcgcgt cgcaccgtcg catgcgcggc ggtatcctgc ccctccttat tccactgatc 24600
gccgcggcga ttggcgccgt gcccggaatt gcatccgtgg ccttgcaggc gcagagacac 24660
tgattaaaaa caagttgcat gtggaaaaat caaaataaaa agtctggact ctcacgctcg 24720
cttggtcctg taactatttt gtagaatgga agacatcaac tttgcgtctc tggccccgcg 24780
acacggctcg cgcccgttca tgggaaactg gcaagatatc ggcaccagca atatgagcgg 24840
tggcgccttc agctggggct cgctgtggag cggcattaaa aatttcggtt ccaccgttaa 24900
gaactatggc agcaaggcct ggaacagcag cacaggccag atgctgaggg ataagttgaa 24960
agagcaaaat ttccaacaaa aggtggtaga tggcctggcc tctggcatta gcggggtggt 25020
ggacctggcc aaccaggcag tgcaaaataa gattaacagt aagcttgatc cccgccctcc 25080
cgtagaggag cctccaccgg ccgtggagac agtgtctcca gaggggcgtg gcgaaaagcg 25140
tccgcgcccc gacagggaag aaactctggt gacgcaaata gacgagcctc cctcgtacga 25200
ggaggcacta aagcaaggcc tgcccaccac ccgtcccatc gcgcccatgg ctaccggagt 25260
gctgggccag cacacacccg taacgctgga cctgcctccc cccgccgaca cccagcagaa 25320
acctgtgctg ccaggcccga ccgccgttgt tgtaacccgt cctagccgcg cgtccctgcg 25380
ccgcgccgcc agcggtccgc gatcgttgcg gcccgtagcc agtggcaact ggcaaagcac 25440
actgaacagc atcgtgggtc tgggggtgca atccctgaag cgccgacgat gcttctgaat 25500
agctaacgtg tcgtatgtgt gtcatgtatg cgtccatgtc gccgccagag gagctgctga 25560
gccgccgcgc gcccgctttc caagatggct accccttcga tgatgccgca gtggtcttac 25620
atgcacatct cgggccagga cgcctcggag tacctgagcc ccgggctggt gcagtttgcc 25680
cgcgccaccg agacgtactt cagcctgaat aacaagttta gaaaccccac ggtggcgcct 25740
acgcacgacg tgaccacaga ccggtcccag cgtttgacgc tgcggttcat ccctgtggac 25800
cgtgaggata ctgcgtactc gtacaaggcg cggttcaccc tagctgtggg tgataaccgt 25860
gtgctggaca tggcttccac gtactttgac atccgcggcg tgctggacag gggccctact 25920
tttaagccct actctggcac tgcctacaac gccctggctc ccaagggtgc cccaaatcct 25980
tgcgaatggg atgaagctgc tactgctctt gaaataaacc tagaagaaga ggacgatgac 26040
aacgaagacg aagtagacga gcaagctgag cagcaaaaaa ctcacgtatt tgggcaggcg 26100
ccttattctg gtataaatat tacaaaggag ggtattcaaa taggtgtcga aggtcaaaca 26160
cctaaatatg ccgataaaac atttcaacct gaacctcaaa taggagaatc tcagtggtac 26220
gaaactgaaa ttaatcatgc agctgggaga gtccttaaaa agactacccc aatgaaacca 26280
tgttacggtt catatgcaaa acccacaaat gaaaatggag ggcaaggcat tcttgtaaag 26340
caacaaaatg gaaagctaga aagtcaagtg gaaatgcaat ttttctcaac tactgaggcg 26400
accgcaggca atggtgataa cttgactcct aaagtggtat tgtacagtga agatgtagat 26460
atagaaaccc cagacactca tatttcttac atgcccacta ttaaggaagg taactcacga 26520
gaactaatgg gccaacaatc tatgcccaac aggcctaatt acattgcttt tagggacaat 26580
tttattggtc taatgtatta caacagcacg ggtaatatgg gtgttctggc gggccaagca 26640
tcgcagttga atgctgttgt agatttgcaa gacagaaaca cagagctttc ataccagctt 26700
ttgcttgatt ccattggtga tagaaccagg tacttttcta tgtggaatca ggctgttgac 26760
agctatgatc cagatgttag aattattgaa aatcatggaa ctgaagatga acttccaaat 26820
tactgctttc cactgggagg tgtgattaat acagagactc ttaccaaggt aaaacctaaa 26880
acaggtcagg aaaatggatg ggaaaaagat gctacagaat tttcagataa aaatgaaata 26940
agagttggaa ataattttgc catggaaatc aatctaaatg ccaacctgtg gagaaatttc 27000
ctgtactcca acatagcgct gtatttgccc gacaagctaa agtacagtcc ttccaacgta 27060
aaaatttctg ataacccaaa cacctacgac tacatgaaca agcgagtggt ggctcccggg 27120
ttagtggact gctacattaa ccttggagca cgctggtccc ttgactatat ggacaacgtc 27180
aacccattta accaccaccg caatgctggc ctgcgctacc gctcaatgtt gctgggcaat 27240
ggtcgctatg tgcccttcca catccaggtg cctcagaagt tctttgccat taaaaacctc 27300
cttctcctgc cgggctcata cacctacgag tggaacttca ggaaggatgt taacatggtt 27360
ctgcagagct ccctaggaaa tgacctaagg gttgacggag ccagcattaa gtttgatagc 27420
atttgccttt acgccacctt cttccccatg gcccacaaca ccgcctccac gcttgaggcc 27480
atgcttagaa acgacaccaa cgaccagtcc tttaacgact atctctccgc cgccaacatg 27540
ctctacccta tacccgccaa cgctaccaac gtgcccatat ccatcccctc ccgcaactgg 27600
gcggctttcc gcggctgggc cttcacgcgc cttaagacta aggaaacccc atcactgggc 27660
tcgggctacg acccttatta cacctactct ggctctatac cctacctaga tggaaccttt 27720
tacctcaacc acacctttaa gaaggtggcc attacctttg actcttctgt cagctggcct 27780
ggcaatgacc gcctgcttac ccccaacgag tttgaaatta agcgctcagt tgacggggag 27840
ggttacaacg ttgcccagtg taacatgacc aaagactggt tcctggtaca aatgctagct 27900
aactacaaca ttggctacca gggcttctat atcccagaga gctacaagga ccgcatgtac 27960
tccttcttta gaaacttcca gcccatgagc cgtcaggtgg tggatgatac taaatacaag 28020
gactaccaac aggtgggcat cctacaccaa cacaacaact ctggatttgt tggctacctt 28080
gcccccacca tgcgcgaagg acaggcctac cctgctaact tcccctatcc gcttataggc 28140
aagaccgcag ttgacagcat tacccagaaa aagtttcttt gcgatcgcac cctttggcgc 28200
atcccattct ccagtaactt tatgtccatg ggcgcactca cagacctggg ccaaaacctt 28260
ctctacgcca actccgccca cgcgctagac atgacttttg aggtggatcc catggacgag 28320
cccacccttc tttatgtttt gtttgaagtc tttgacgtgg tccgtgtgca ccggccgcac 28380
cgcggcgtca tcgaaaccgt gtacctgcgc acgcccttct cggccggcaa cgccacaaca 28440
taaagaagca agcaacatca acaacagctg ccgccatggg ctccagtgag caggaactga 28500
aagccattgt caaagatctt ggttgtgggc catatttttt gggcacctat gacaagcgct 28560
ttccaggctt tgtttctcca cacaagctcg cctgcgccat agtcaatacg gccggtcgcg 28620
agactggggg cgtacactgg atggcctttg cctggaaccc gcactcaaaa acatgctacc 28680
tctttgagcc ctttggcttt tctgaccagc gactcaagca ggtttaccag tttgagtacg 28740
agtcactcct gcgccgtagc gccattgctt cttcccccga ccgctgtata acgctggaaa 28800
agtccaccca aagcgtacag gggcccaact cggccgcctg tggactattc tgctgcatgt 28860
ttctccacgc ctttgccaac tggccccaaa ctcccatgga tcacaacccc accatgaacc 28920
ttattaccgg ggtacccaac tccatgctca acagtcccca ggtacagccc accctgcgtc 28980
gcaaccagga acagctctac agcttcctgg agcgccactc gccctacttc cgcagccaca 29040
gtgcgcagat taggagcgcc acttcttttt gtcacttgaa aaacatgtaa aaataatgta 29100
ctagagacac tttcaataaa ggcaaatgct tttatttgta cactctcggg tgattattta 29160
cccccaccct tgccgtctgc gccgtttaaa aatcaaaggg gttctgccgc gcatcgctat 29220
gcgccactgg cagggacacg ttgcgatact ggtgtttagt gctccactta aactcaggca 29280
caaccatccg cggcagctcg gtgaagtttt cactccacag gctgcgcacc atcaccaacg 29340
cgtttagcag gtcgggcgcc gatatcttga agtcgcagtt ggggcctccg ccctgcgcgc 29400
gcgagttgcg atacacaggg ttgcagcact ggaacactat cagcgccggg tggtgcacgc 29460
tggccagcac gctcttgtcg gagatcagat ccgcgtccag gtcctccgcg ttgctcaggg 29520
cgaacggagt caactttggt agctgccttc ccaaaaaggg cgcgtgccca ggctttgagt 29580
tgcactcgca ccgtagtggc atcaaaaggt gaccgtgccc ggtctgggcg ttaggataca 29640
gcgcctgcat aaaagccttg atctgcttaa aagccacctg agcctttgcg ccttcagaga 29700
agaacatgcc gcaagacttg ccggaaaact gattggccgg acaggccgcg tcgtgcacgc 29760
agcaccttgc gtcggtgttg gagatctgca ccacatttcg gccccaccgg ttcttcacga 29820
tcttggcctt gctagactgc tccttcagcg cgcgctgccc gttttcgctc gtcacatcca 29880
tttcaatcac gtgctcctta tttatcataa tgcttccgtg tagacactta agctcgcctt 29940
cgatctcagc gcagcggtgc agccacaacg cgcagcccgt gggctcgtga tgcttgtagg 30000
tcacctctgc aaacgactgc aggtacgcct gcaggaatcg ccccatcatc gtcacaaagg 30060
tcttgttgct ggtgaaggtc agctgcaacc cgcggtgctc ctcgttcagc caggtcttgc 30120
atacggccgc cagagcttcc acttggtcag gcagtagttt gaagttcgcc tttagatcgt 30180
tatccacgtg gtacttgtcc atcagcgcgc gcgcagcctc catgcccttc tcccacgcag 30240
acacgatcgg cacactcagc gggttcatca ccgtaatttc actttccgct tcgctgggct 30300
cttcctcttc ctcttgcgtc cgcataccac gcgccactgg gtcgtcttca ttcagccgcc 30360
gcactgtgcg cttacctcct ttgccatgct tgattagcac cggtgggttg ctgaaaccca 30420
ccatttgtag cgccacatct tctctttctt cctcgctgtc cacgattacc tctggtgatg 30480
gcgggcgctc gggcttggga gaagggcgct tctttttctt cttgggcgca atggccaaat 30540
ccgccgccga ggtcgatggc cgcgggctgg gtgtgcgcgg caccagcgcg tcttgtgatg 30600
agtcttcctc gtcctcggac tcgatacgcc gcctcatccg cttttttggg ggcgcccggg 30660
gaggcggcgg cgacggggac ggggacgaca cgtcctccat ggttggggga cgtcgcgccg 30720
caccgcgtcc gcgctcgggg gtggtttcgc gctgctcctc ttcccgactg gccatttcct 30780
tctcctatag gcagaaaaag atcatggagt cagtcgagaa gaaggacagc ctaaccgccc 30840
cctctgagtt cgccaccacc gcctccaccg atgccgccaa cgcgcctacc accttccccg 30900
tcgaggcacc cccgcttgag gaggaggaag tgattatcga gcaggaccca ggttttgtaa 30960
gcgaagacga cgaggaccgc tcagtaccaa cagaggataa aaagcaagac caggacaacg 31020
cagaggcaaa cgaggaacaa gtcgggcggg gggacgaaag gcatggcgac tacctagatg 31080
tgggagacga cgtgctgttg aagcatctgc agcgccagtg cgccattatc tgcgacgcgt 31140
tgcaagagcg cagcgatgtg cccctcgcca tagcggatgt cagccttgcc tacgaacgcc 31200
acctattctc accgcgcgta ccccccaaac gccaagaaaa cggcacatgc gagcccaacc 31260
cgcgcctcaa cttctacccc gtatttgccg tgccagaggt gcttgccacc tatcacatct 31320
ttttccaaaa ctgcaagata cccctatcct gccgtgccaa ccgcagccga gcggacaagc 31380
agctggcctt gcggcagggc gctgtcatac ctgatatcgc ctcgctcaac gaagtgccaa 31440
aaatctttga gggtcttgga cgcgacgaga agcgcgcggc aaacgctctg caacaggaaa 31500
acagcgaaaa tgaaagtcac tctggagtgt tggtggaact cgagggtgac aacgcgcgcc 31560
tagccgtact aaaacgcagc atcgaggtca cccactttgc ctacccggca cttaacctac 31620
cccccaaggt catgagcaca gtcatgagtg agctgatcgt gcgccgtgcg cagcccctgg 31680
agagggatgc aaatttgcaa gaacaaacag aggagggcct acccgcagtt ggcgacgagc 31740
agctagcgcg ctggcttcaa acgcgcgagc ctgccgactt ggaggagcga cgcaaactaa 31800
tgatggccgc agtgctcgtt accgtggagc ttgagtgcat gcagcggttc tttgctgacc 31860
cggagatgca gcgcaagcta gaggaaacat tgcactacac ctttcgacag ggctacgtac 31920
gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac cttggaattt 31980
tgcacgaaaa ccgccttggg caaaacgtgc ttcattccac gctcaagggc gaggcgcgcc 32040
gcgactacgt ccgcgactgc gtttacttat ttctatgcta cacctggcag acggccatgg 32100
gcgtttggca gcagtgcttg gaggagtgca acctcaagga gctgcagaaa ctgctaaagc 32160
aaaacttgaa ggacctatgg acggccttca acgagcgctc cgtggccgcg cacctggcgg 32220
acatcatttt ccccgaacgc ctgcttaaaa ccctgcaaca gggtctgcca gacttcacca 32280
gtcaaagcat gttgcagaac tttaggaact ttatcctaga gcgctcagga atcttgcccg 32340
ccacctgctg tgcacttcct agcgactttg tgcccattaa gtaccgcgaa tgccctccgc 32400
cgctttgggg ccactgctac cttctgcagc tagccaacta ccttgcctac cactctgaca 32460
taatggaaga cgtgagcggt gacggtctac tggagtgtca ctgtcgctgc aacctatgca 32520
ccccgcaccg ctccctggtt tgcaattcgc agctgcttaa cgaaagtcaa attatcggta 32580
cctttgagct gcagggtccc tcgcctgacg aaaagtccgc ggctccgggg ttgaaactca 32640
ctccggggct gtggacgtcg gcttaccttc gcaaatttgt acctgaggac taccacgccc 32700
acgagattag gttctacgaa gaccaatccc gcccgccaaa tgcggagctt accgcctgcg 32760
tcattaccca gggccacatt cttggccaat tgcaagccat caacaaagcc cgccaagagt 32820
ttctgctacg aaagggacgg ggggtttact tggaccccca gtccggcgag gagctcaacc 32880
caatcccccc gccgccgcag ccctatcagc agcagccgcg ggcccttgct tcccaggatg 32940
gcacccaaaa agaagctgca gctgccgccg ccacccacgg acgaggagga atactgggac 33000
agtcaggcag aggaggtttt ggacgaggag gaggaggaca tgatggaaga ctgggagagc 33060
ctagacgagg aagcttccga ggtcgaagag gtgtcagacg aaacaccgtc accctcggtc 33120
gcattcccct cgccggcgcc ccagaaatcg gcaaccggtt ccagcatggc tacaacctcc 33180
gctcctcagg cgccgccggc actgcccgtt cgccgaccca accgtagatg ggacaccact 33240
ggaaccaggg ccggtaagtc caagcagccg ccgccgttag cccaagagca acaacagcgc 33300
caaggctacc gctcatggcg cgggcacaag aacgccatag ttgcttgctt gcaagactgt 33360
gggggcaaca tctccttcgc ccgccgcttt cttctctacc atcacggcgt ggccttcccc 33420
cgtaacatcc tgcattacta ccgtcatctc tacagcccat actgcaccgg cggcagcggc 33480
agcggcagca acagcagcgg ccacacagaa gcaaaggcga ccggatagca agactctgac 33540
aaagcccaag aaatccacag cggcggcagc agcaggagga ggagcgctgc gtctggcgcc 33600
caacgaaccc gtatcgaccc gcgagcttag aaacaggatt tttcccactc tgtatgctat 33660
atttcaacag agcaggggcc aagaacaaga gctgaaaata aaaaacaggt ctctgcgatc 33720
cctcacccgc agctgcctgt atcacaaaag cgaagatcag cttcggcgca cgctggaaga 33780
cgcggaggct ctcttcagta aatactgcgc gctgactctt aaggactagt ttcgcgccct 33840
ttctcaaatt taagcgcgaa aactacgtca tctccagcgg ccacacccgg cgccagcacc 33900
tgtcgtcagc gccattatga gcaaggaaat tcccacgccc tacatgtgga gttaccagcc 33960
acaaatggga cttgcggctg gagctgccca agactactca acccgaataa actacatgag 34020
cgcgggaccc cacatgatat cccgggtcaa cggaatccgc gcccaccgaa accgaattct 34080
cttggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc gtagttggcc 34140
cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc ccagagacgc 34200
ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag 34260
ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag gtattcagct 34320
caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat ttcagatcgg 34380
cggcgccggc cgtccttcat tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc 34440
ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt ttgtgccatc 34500
ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat ttattcctaa 34560
ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg gagaggcaga 34620
gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg cccgcgactc 34680
cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg cgcacggcgt 34740
ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta cccagcgccc 34800
cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca actgtcctaa 34860
ccttggatta catcaagatc tttgttgcca tctctgtgct gagtataata aatacagaaa 34920
ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa 34980
gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg atttacaaca 35040
gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc tactccatca 35100
gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg gccgctgcac 35160
cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat aactctgttt 35220
accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg cgcagctact 35280
gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg tttctctaga 35340
aatggacgga attattacag agcagcgcct gctagaaaga cgcagggcag cggccgagca 35400
acagcgcatg aatcaagagc tccaagacat ggttaacttg caccagtgca aaaggggtat 35460
cttttgtctg gtaaagcagg ccaaagtcac ctacgacagt aataccaccg gacaccgcct 35520
tagctacaag ttgccaacca agcgtcagaa attggtggtc atggtgggag aaaagcccat 35580
taccataact cagcactcgg tagaaaccga aggctgcatt cactcacctt gtcaaggacc 35640
tgaggatctc tgcaccctta ttaagaccct gtgcggtctc aaagatctta ttccctttaa 35700
ctaataaaaa aaaataataa agcatcactt acttaaaatc agttagcaaa tttctgtcca 35760
gtttattcag cagcacctcc ttgccctcct cccagctctg gtattgcagc ttcctcctgg 35820
ctgcaaactt tctccacaat ctaaatggaa tgtcagtttc ctcctgttcc tgtccatccg 35880
cacccactat cttcatgttg ttgcagatga agcgcgcaag accgtctgaa gataccttca 35940
accccgtgta tccatatgac acggaaaccg gtcctccaac tgtgcctttt cttactcctc 36000
cctttgtatc ccccaatggg tttcaagaga gtccccctgg ggtactctct ttgcgcctat 36060
ccgaacctct agttacctcc aatggcatgc ttgcgctcaa aatgggcaac ggcctctctc 36120
tggacgaggc cggcaacctt acctcccaaa atgtaaccac tgtgagccca cctctcaaaa 36180
aaaccaagtc aaacataaac ctggaaatat ctgcacccct cacagttacc tcagaagccc 36240
taactgtggc tgccgccgca cctctaatgg tcgcgggcaa cacactcacc atgcaatcac 36300
aggccccgct aaccgtgcac gactccaaac ttagcattgc cacccaagga cccctcacag 36360
tgtcagaagg aaagctagcc ctgcaaacat caggccccct caccaccacc gatagcagta 36420
cccttactat cactgcctca ccccctctaa ctactgccac tggtagcttg ggcattgact 36480
tgaaagagcc catttataca caaaatggaa aactaggact aaagtacggg gctcctttgc 36540
atgtaacaga cgacctaaac actttgaccg tagcaactgg tccaggtgtg actattaata 36600
atacttcctt gcaaactaaa gttactggag ccttgggttt tgattcacaa ggcaatatgc 36660
aacttaatgt agcaggagga ctaaggattg attctcaaaa cagacgcctt atacttgatg 36720
ttagttatcc gtttgatgct caaaaccaac taaatctaag actaggacag ggccctcttt 36780
ttataaactc agcccacaac ttggatatta actacaacaa aggcctttac ttgtttacag 36840
cttcaaacaa ttccaaaaag cttgaggtta acctaagcac tgccaagggg ttgatgtttg 36900
acgctacagc catagccatt aatgcaggag atgggcttga atttggttca cctaatgcac 36960
caaacacaaa tcccctcaaa acaaaaattg gccatggcct agaatttgat tcaaacaagg 37020
ctatggttcc taaactagga actggcctta gttttgacag cacaggtgcc attacagtag 37080
gaaacaaaaa taatgataag ctaactttgt ggaccacacc agctccatct cctaactgta 37140
gactaaatgc agagaaagat gctaaactca ctttggtctt aacaaaatgt ggcagtcaaa 37200
tacttgctac agtttcagtt ttggctgtta aaggcagttt ggctccaata tctggaacag 37260
ttcaaagtgc tcatcttatt ataagatttg acgaaaatgg agtgctacta aacaattcct 37320
tcctggaccc agaatattgg aactttagaa atggagatct tactgaaggc acagcctata 37380
caaacgctgt tggatttatg cctaacctat cagcttatcc aaaatctcac ggtaaaactg 37440
ccaaaagtaa cattgtcagt caagtttact taaacggaga caaaactaaa cctgtaacac 37500
taaccattac actaaacggt acacaggaaa caggagacac aactccaagt gcatactcta 37560
tgtcattttc atgggactgg tctggccaca actacattaa tgaaatattt gccacatcct 37620
cttacacttt ttcatacatt gcccaagaat aaagaatcgt ttgtgttatg tttcaacgtg 37680
tttatttttc aattgcagaa aatttcgaat catttttcat tcagtagtat agccccacca 37740
ccacatagct tatacagatc accgtacctt aatcaaactc acagaaccct agtattcaac 37800
ctgccacctc cctcccaaca cacagagtac acagtccttt ctccccggct ggccttaaaa 37860
agcatcatat catgggtaac agacatattc ttaggtgtta tattccacac ggtttcctgt 37920
cgagccaaac gctcatcagt gatattaata aactccccgg gcagctcact taagttcatg 37980
tcgctgtcca gctgctgagc cacaggctgc tgtccaactt gcggttgctt aacgggcggc 38040
gaaggagaag tccacgccta catgggggta gagtcataat cgtgcatcag gatagggcgg 38100
tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct gcaggaatac 38160
aacatggcag tggtctcctc agcgatgatt cgcaccgccc gcagcataag gcgccttgtc 38220
ctccgggcac agcagcgcac cctgatctca cttaaatcag cacagtaact gcagcacagc 38280
accacaatat tgttcaaaat cccacagtgc aaggcgctgt atccaaagct catggcgggg 38340
accacagaac ccacgtggcc atcataccac aagcgcaggt agattaagtg gcgacccctc 38400
ataaacacgc tggacataaa cattacctct tttggcatgt tgtaattcac cacctcccgg 38460
taccatataa acctctgatt aaacatggcg ccatccacca ccatcctaaa ccagctggcc 38520
aaaacctgcc cgccggctat acactgcagg gaaccgggac tggaacaatg acagtggaga 38580
gcccaggact cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac 38640
aggcacacgt gcatacactt cctcaggatt acaagctcct cccgcgttag aaccatatcc 38700
cagggaacaa cccattcctg aatcagcgta aatcccacac tgcagggaag acctcgcacg 38760
taactcacgt tgtgcattgt caaagtgtta cattcgggca gcagcggatg atcctccagt 38820
atggtagcgc gggtttctgt ctcaaaagga ggtagacgat ccctactgta cggagtgcgc 38880
cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc 38940
atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg 39000
ccgcttagat cgctctgtgt agtagttgta gtatatccac tctctcaaag catccaggcg 39060
ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga taacatccac 39120
caccgcagaa taagccacac ccagccaacc tacacattcg ttctgcgagt cacacacggg 39180
aggagcggga agagctggaa gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa 39240
cctcaaaatg aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta 39300
cagccaaaga acagataatg gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa 39360
cggccctcac gtccaagtgg acgtaaaggc taaacccttc agggtgaatc tcctctataa 39420
acattccagc accttcaacc atgcccaaat aattctcatc tcgccacctt ctcaatatat 39480
ctctaagcaa atcccgaata ttaagtccgg ccattgtaaa aatctgctcc agagcgccct 39540
ccaccttcag cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct cacagacctg 39600
tataagattc aaaagcggaa cattaacaaa aataccgcga tcccgtaggt cccttcgcag 39660
ggccagctga acataatcgt gcaggtctgc acggaccagc gcggccactt ccccgccagg 39720
aaccttgaca aaagaaccca cactgattat gacacgcata ctcggagcta tgctaaccag 39780
cgtagccccg atgtaagctt tgttgcatgg gcggcgatat aaaatgcaag gtgctgctca 39840
aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc gtagtcatgc tcatgcagat 39900
aaaggcaggt aagctccgga accaccacag aaaaagacac catttttctc tcaaacatgt 39960
ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa aacatttaaa cattagaagc 40020
ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg ccatgccggc 40080
gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagct cctcggtcat 40140
gtccggagtc ataatgtaag actcggtaaa cacatcaggt tgattcacat cggtcagtgc 40200
taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag acaacattac 40260
agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa cacctgaaaa 40320
accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca gcgcttccac 40380
agcggcagcc ataacagtca gccttaccag taaaaaagaa aacctattaa aaaaacacca 40440
ctcgacacgg cacataactt cgtatagcat acattatacg aagttatcag ctcaatcagt 40500
cacagtgtaa aaaagggcca agtgcagagc gagtatatat aggactaaaa aatgacgtaa 40560
cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg aacctacgcc cagaaacgaa 40620
agccaaaaaa cccacaactt cctcaaatcg tcacttccgt tttcccacgt tacgtcactt 40680
cccattttaa gaaaactaca attcccaaca catacaagtt actccgccct aaaacctacg 40740
tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac tccaccccct cattatcata 40800
ttggcttcaa tccaaaataa ggtatattat tgatgatgcc tccggggtcc actgcaatta 40860
ataacttcgt atagcataca ttatacgaag ttatttaatt aagggcggcc gcacgggcca 40920
tcgatgggga tcctaacttt aaataatgcc aattatttaa agttaccaac tattttgtcc 40980
gcccacaggt accctgtgaa tgcgcaaacc aacccttggc agaacatatc catcgcgtcc 41040
gccatctcca gcagccgcac gcggcgcatc tcgggcagcg ttgggtcctg gccacgggtg 41100
cgcatgatcg tgctcctgtc gttgaggacc cggctaggct ggcggggttg ccttactggt 41160
tagcagaatg aatcaccgat acgcgagcga acgtgaagcg actgctgctg caaaacgtct 41220
gcgacctgag caacaacatg aatggtcttc ggtttccgtg tttcgtaaag tctggaaacg 41280
cggaagtcag cgccctgcac cattatgttc cggaacgtac gaagcatgct aattttgtgt 41340
tactcatgca ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct 41400
atttcccatg attccttcat atttgcatat acgatacaag gctgttagag agataattag 41460
aattaatttg actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata 41520
atttcttggg tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac 41580
cgtaacttga aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac 41640
ctaattgcag tggaccccgg gttttagagc tagaaatagc aagttaaaat aaggctagtc 41700
cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttaagcttga attcgctagc 41760
taggtcttga aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg 41820
cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg 41880
tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt 41940
gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt 42000
gccgccagaa cacaggaccg gttctagagc caccatggac aagaagtaca gcatcggcct 42060
ggacatcggc accaactctg tgggctgggc cgtgatcacc gacgagtaca aggtgcccag 42120
caagaaattc aaggtgctgg gcaacaccga ccggcacagc atcaagaaga acctgatcgg 42180
agccctgctg ttcgacagcg gcgaaacagc cgaggccacc cggctgaaga gaaccgccag 42240
aagaagatac accagacgga agaaccggat ctgctatctg caagagatct tcagcaacga 42300
gatggccaag gtggacgaca gcttcttcca cagactggaa gagtccttcc tggtggaaga 42360
ggataagaag cacgagcggc accccatctt cggcaacatc gtggacgagg tggcctacca 42420
cgagaagtac cccaccatct accacctgag aaagaaactg gtggacagca ccgacaaggc 42480
cgacctgcgg ctgatctatc tggccctggc ccacatgatc aagttccggg gccacttcct 42540
gatcgagggc gacctgaacc ccgacaacag cgacgtggac aagctgttca tccagctggt 42600
gcagacctac aaccagctgt tcgaggaaaa ccccatcaac gccagcggcg tggacgccaa 42660
ggccatcctg tctgccagac tgagcaagag cagacggctg gaaaatctga tcgcccagct 42720
gcccggcgag aagaagaatg gcctgttcgg aaacctgatt gccctgagcc tgggcctgac 42780
ccccaacttc aagagcaact tcgacctggc cgaggatgcc aaactgcagc tgagcaagga 42840
cacctacgac gacgacctgg acaacctgct ggcccagatc ggcgaccagt acgccgacct 42900
gtttctggcc gccaagaacc tgtccgacgc catcctgctg agcgacatcc tgagagtgaa 42960
caccgagatc accaaggccc ccctgagcgc ctctatgatc aagagatacg acgagcacca 43020
ccaggacctg accctgctga aagctctcgt gcggcagcag ctgcctgaga agtacaaaga 43080
gattttcttc gaccagagca agaacggcta cgccggctac attgacggcg gagccagcca 43140
ggaagagttc tacaagttca tcaagcccat cctggaaaag atggacggca ccgaggaact 43200
gctcgtgaag ctgaacagag aggacctgct gcggaagcag cggaccttcg acaacggcag 43260
catcccccac cagatccacc tgggagagct gcacgccatt ctgcggcggc aggaagattt 43320
ttacccattc ctgaaggaca accgggaaaa gatcgagaag atcctgacct tccgcatccc 43380
ctactacgtg ggccctctgg ccaggggaaa cagcagattc gcctggatga ccagaaagag 43440
cgaggaaacc atcaccccct ggaacttcga ggaagtggtg gacaagggcg cttccgccca 43500
gagcttcatc gagcggatga ccaacttcga taagaacctg cccaacgaga aggtgctgcc 43560
caagcacagc ctgctgtacg agtacttcac cgtgtataac gagctgacca aagtgaaata 43620
cgtgaccgag ggaatgagaa agcccgcctt cctgagcggc gagcagaaaa aggccatcgt 43680
ggacctgctg ttcaagacca accggaaagt gaccgtgaag cagctgaaag aggactactt 43740
caagaaaatc gagtgcttcg actccgtgga aatctccggc gtggaagatc ggttcaacgc 43800
ctccctgggc acataccacg atctgctgaa aattatcaag gacaaggact tcctggacaa 43860
tgaggaaaac gaggacattc tggaagatat cgtgctgacc ctgacactgt ttgaggacag 43920
agagatgatc gaggaacggc tgaaaaccta tgcccacctg ttcgacgaca aagtgatgaa 43980
gcagctgaag cggcggagat acaccggctg gggcaggctg agccggaagc tgatcaacgg 44040
catccgggac aagcagtccg gcaagacaat cctggatttc ctgaagtccg acggcttcgc 44100
caacagaaac ttcatgcagc tgatccacga cgacagcctg acctttaaag aggacatcca 44160
gaaagcccag gtgtccggcc agggcgatag cctgcacgag cacattgcca atctggccgg 44220
cagccccgcc attaagaagg gcatcctgca gacagtgaag gtggtggacg agctcgtgaa 44280
agtgatgggc cggcacaagc ccgagaacat cgtgatcgaa atggccagag agaaccagac 44340
cacccagaag ggacagaaga acagccgcga gagaatgaag cggatcgaag agggcatcaa 44400
agagctgggc agccagatcc tgaaagaaca ccccgtggaa aacacccagc tgcagaacga 44460
gaagctgtac ctgtactacc tgcagaatgg gcgggatatg tacgtggacc aggaactgga 44520
catcaaccgg ctgtccgact acgatgtgga ccatatcgtg cctcagagct ttctgaagga 44580
cgactccatc gacaacaagg tgctgaccag aagcgacaag aaccggggca agagcgacaa 44640
cgtgccctcc gaagaggtcg tgaagaagat gaagaactac tggcggcagc tgctgaacgc 44700
caagctgatt acccagagaa agttcgacaa tctgaccaag gccgagagag gcggcctgag 44760
cgaactggat aaggccggct tcatcaagag acagctggtg gaaacccggc agatcacaaa 44820
gcacgtggca cagatcctgg actcccggat gaacactaag tacgacgaga atgacaagct 44880
gatccgggaa gtgaaagtga tcaccctgaa gtccaagctg gtgtccgatt tccggaagga 44940
tttccagttt tacaaagtgc gcgagatcaa caactaccac cacgcccacg acgcctacct 45000
gaacgccgtc gtgggaaccg ccctgatcaa aaagtaccct aagctggaaa gcgagttcgt 45060
gtacggcgac tacaaggtgt acgacgtgcg gaagatgatc gccaagagcg agcaggaaat 45120
cggcaaggct accgccaagt acttcttcta cagcaacatc atgaactttt tcaagaccga 45180
gattaccctg gccaacggcg agatccggaa gcggcctctg atcgagacaa acggcgaaac 45240
cggggagatc gtgtgggata agggccggga ttttgccacc gtgcggaaag tgctgagcat 45300
gccccaagtg aatatcgtga aaaagaccga ggtgcagaca ggcggcttca gcaaagagtc 45360
tatcctgccc aagaggaaca gcgataagct gatcgccaga aagaaggact gggaccctaa 45420
gaagtacggc ggcttcgaca gccccaccgt ggcctattct gtgctggtgg tggccaaagt 45480
ggaaaagggc aagtccaaga aactgaagag tgtgaaagag ctgctgggga tcaccatcat 45540
ggaaagaagc agcttcgaga agaatcccat cgactttctg gaagccaagg gctacaaaga 45600
agtgaaaaag gacctgatca tcaagctgcc taagtactcc ctgttcgagc tggaaaacgg 45660
ccggaagaga atgctggcct ctgccggcga actgcagaag ggaaacgaac tggccctgcc 45720
ctccaaatat gtgaacttcc tgtacctggc cagccactat gagaagctga agggctcccc 45780
cgaggataat gagcagaaac agctgtttgt ggaacagcac aagcactacc tggacgagat 45840
catcgagcag atcagcgagt tctccaagag agtgatcctg gccgacgcta atctggacaa 45900
agtgctgtcc gcctacaaca agcaccggga taagcccatc agagagcagg ccgagaatat 45960
catccacctg tttaccctga ccaatctggg agcccctgcc gccttcaagt actttgacac 46020
caccatcgac cggaagaggt acaccagcac caaagaggtg ctggacgcca ccctgatcca 46080
ccagagcatc accggcctgt acgagacacg gatcgacctg tctcagctgg gaggcgacaa 46140
gcgacctgcc gccacaaaga aggctggaca ggctaagaag aagaaagatt acaaagacga 46200
tgacgataag tgactcgagt aaggatccgc ccctctccct cccccccccc taacgttact 46260
ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata 46320
ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt 46380
cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa 46440
gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag 46500
cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca 46560
cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc 46620
aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat 46680
tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta 46740
aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga 46800
taatatggcc acaaccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat 46860
cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga 46920
gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc 46980
cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta 47040
ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca 47100
ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt 47160
cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg 47220
caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc 47280
cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg 47340
cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct 47400
gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa 47460
gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga 47520
cgagctgtac aagtaaagcg gccgcgactc tagatcataa tcagccatac cacatttgta 47580
gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 47640
aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 47700
agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 47760
aaactcatca atgtatctta aatcgaattg gtcaggtggc acttttcggg gaaatgtgcg 47820
cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca 47880
ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt 47940
ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga 48000
aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga 48060
actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttctccaat 48120
gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca 48180
agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt 48240
cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac 48300
catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct 48360
aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga 48420
gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac 48480
aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat 48540
agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg 48600
ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc 48660
actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc 48720
aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg 48780
gtaactgtca gaccaagttt aat 48803
<210> 38
<211> 40811
<212> DNA
<213> 人工序列
<220>
<223> pBWH-L-C5-mChe
<400> 38
taacatatgg atttattcaa caaagccacg ttgtgtctca aaatctctga tgttacattg 60
cacaagataa aaatatatca tcatgaacaa taaaactgtc tgcttacata aacagtaata 120
caaggggtgt tatgagccat attcaacggg aaacgtcttg ctcgaggccg cgattaaatt 180
ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc gggcaatcag 240
gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg 300
gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac tggctgacgg 360
aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat gcatggttac 420
tcaccactgc gatccccggg aaaacagcat tccaggtatt agaagaatat cctgattcag 480
gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg attcctgttt 540
gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga 600
ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg cctgttgaac 660
aagtctggaa agaaatgcat aagcttttgc cattctcacc ggattcagtc gtcactcatg 720
gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt tgtattgatg 780
ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg aactgcctcg 840
gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt gataatcctg 900
atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaatca gaattggtta 960
attggttgta acactgggca tgctaattgc agtggacccc ggaggcatca tcaataatat 1020
accttatttt ggattgaagc caatatgata atgagggggt ggagtttgtg acgtggcgcg 1080
gggcgtggga acggggcggg tgacgtagta gtgtggcgga agtgtgatgt tgcaagtgtg 1140
gcggaacaca tgtaagcgac ggatgtggca aaagtgacgt ttttggtgtg cgccggtgta 1200
cacaggaagt gacaattttc gcgcggtttt aggcggatgt tgtagtaaat ttgggcgtaa 1260
ccgagtaaga tttggccatt ttcgcgggaa aactgaataa gaggaagtga aatctgaata 1320
attttgtgtt actcatagcg cgtaataata gtaatcaatt acggggtcat tagttcatag 1380
cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc 1440
caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg 1500
gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca 1560
tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc 1620
ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt 1680
attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata 1740
gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt 1800
ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca 1860
aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctggtt tagtgaaccg 1920
tcagatccgc tagcgctacc ggactcagat ctcgagctca agcttcgaat tctgcagtcg 1980
acggtaccga gctcggatcc cgccaccatg gtgagcaagg gcgaggagga taacatggcc 2040
atcatcaagg agttcatgcg cttcaaggtg cacatggagg gctccgtgaa cggccacgag 2100
ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg 2160
aaggtgacca agggtggccc cctgcccttc gcctgggaca tcctgtcccc tcagttcatg 2220
tacggctcca aggcctacgt gaagcacccc gccgacatcc ccgactactt gaagctgtcc 2280
ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc 2340
gtgacccagg actcctccct gcaggacggc gagttcatct acaaggtgaa gctgcgcggc 2400
accaacttcc cctccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc 2460
tccgagcgga tgtaccccga ggacggcgcc ctgaagggcg agatcaagca gaggctgaag 2520
ctgaaggacg gcggccacta cgacgctgag gtcaagacca cctacaaggc caagaagccc 2580
gtgcagctgc ccggcgccta caacgtcaac atcaagttgg acatcacctc ccacaacgag 2640
gactacacca tcgtggaaca gtacgaacgc gccgagggcc gccactccac cggcggcatg 2700
gacgagctgt acaagtaaga attctgcaga tatccagcac agtggcggcc gcgactctag 2760
atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa cctcccacac 2820
ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt gtttattgca 2880
gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt 2940
tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttaaat cgaattcaag 3000
cttgtcgact cgaagatctg agctcacgcg tgaagttcct attccgaagt tcctattctc 3060
tagaaagtat aggaacttca gagcgctttt gaagctgggg tgggcgaaga actccagcat 3120
gagatcccca gagcgctttt gaagctgcgt ttaaacgcga tatcccggga gctcccgata 3180
tcgcgtttaa acgcagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt 3240
atccgctcac aattccacac aacatacgag ccggaagact gaaatgtgtg ggcgtggctt 3300
aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 3360
agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 3420
aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 3480
tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 3540
gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 3600
gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 3660
cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 3720
cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 3780
tcccaatgcg gtttaaaaca taaataaaaa accagactct gtttggattt ggatcaagca 3840
agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg accagcggtc 3900
tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac tctggatgtt 3960
cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca gagcttcatg 4020
ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt ggtgcctaaa 4080
aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag tgtttacaaa 4140
gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg actgtatttt 4200
taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca gaaccaccag 4260
cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa atgcgtggaa 4320
gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca taatgatggc 4380
aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa cgtcatagtt 4440
gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga gggtgccaga 4500
ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga tttgcatttc 4560
ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga agaaaacggt 4620
ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct gcgacttacc 4680
gcagccggtg ggcccgtaaa tcacacctat taccgggtgc aactggtagt taagagagct 4740
gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc tgactcgcat 4800
gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca gttcttgcaa 4860
ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt tgagcgtttg 4920
accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat ctcgatccag 4980
catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag tcggtgctcg 5040
tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag cgtagtctgg 5100
gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt gaggctggtc 5160
ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta gcatttgacc 5220
atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt gcccttggag 5280
gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg cgcgagaaat 5340
accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc gcattccacg 5400
agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg ctttttgatg 5460
cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa aaggctgtcc 5520
gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg gtcctcctcg 5580
tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac gaaggaggct 5640
aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag ggtgtgaaga 5700
cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta ggccacgtga 5760
ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc ctcactctct 5820
tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg aaaagcgggc 5880
atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg 5940
cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac aatctttttg 6000
ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt ggcgatggag 6060
cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt tagctgcacg 6120
tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc gggcaccagg 6180
tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc tacctctccg 6240
cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa tggcggtagg 6300
gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc gggcagcagg 6360
cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg ccatgcgcgg 6420
gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg gtgggtgagc 6480
gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag tattccaaga 6540
tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta tagttcgtgc 6600
gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc tcggaagact 6660
atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa gacgttgaag 6720
ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc gcgcagcttg 6780
ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt ttccttgatg 6840
atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac aaactcttcg 6900
cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta agagcctagc 6960
atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg tagcgcgtat 7020
gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa aggtgtccct gaccatgact 7080
ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc cctgctccca gagcaaaaag 7140
tccgtgcgct ttttggaacg cggatttggc agggcgaagg tgacatcgtt gaagagtatc 7200
tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg gtcccggcac ctcggaacgg 7260
ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc cgttgatgtt gtggcccaca 7320
atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag gcaatttttt aagttcctcg 7380
taggtgagct cttcagggga gctgagcccg tgctctgaaa gggcccagtc tgcaagatga 7440
gggttggaag cgacgaatga gctccacagg tcacgggcca ttagcatttg caggtggtcg 7500
cgaaaggtcc taaactggcg acctatggcc attttttctg gggtgatgca gtagaaggta 7560
agcgggtctt gttcccagcg gtcccatcca aggttcgcgg ctaggtctcg cgcggcagtc 7620
actagaggct catctccgcc gaacttcatg accagcatga agggcacgag ctgcttccca 7680
aaggccccca tccaagtata ggtctctaca tcgtaggtga caaagagacg ctcggtgcga 7740
ggatgcgagc cgatcgggaa gaactggatc tcccgccacc aattggagga gtggctattg 7800
atgtggtgaa agtagaagtc cctgcgacgg gccgaacact cgtgctggct tttgtaaaaa 7860
cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct gcacgaggtt gacctgacga 7920
ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc ctggcgggtt tggctggtgg 7980
tcttctactt cggctgcttg tccttgaccg tctggctgct cgaggggagt tacggtggat 8040
cggaccacca cgccgcgcga gcccaaagtc cagatgtccg cgcgcggcgg tcggagcttg 8100
atgacaacat cgcgcagatg ggagctgtcc atggtctgga gctcccgcgg cgtcaggtca 8160
ggcgggagct cctgcaggtt tacctcgcat agacgggtca gggcgcgggc tagatccagg 8220
tgatacctaa tttccagggg ctggttggtg gcggcgtcga tggcttgcaa gaggccgcat 8280
ccccgcggcg cgactacggt accgcgcggc gggcggtggg ccgcgggggt gtccttggat 8340
gatgcatcta aaagcggtga cgcgggcgag cccccggagg tagggggggc tccggacccg 8400
ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg caggagctgg tgctgcgcgc 8460
gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc ctgaatctgg cgcctctgcg 8520
tgaagacgac gggcccggtg agcttgagcc tgaaagagag ttcgacagaa tcaatttcgg 8580
tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc tcctgagttg tcttgatagg 8640
cgatctcggc catgaactgc tcgatctctt cctcctggag atctccgcgt ccggctcgct 8700
ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag ctgcgagaag gcgttgaggc 8760
ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc ggcatcgcgg gcgcgcatga 8820
ccacctgcgc gagattgagc tccacgtgcc gggcgaagac ggcgtagttt cgcaggcgct 8880
gaaagaggta gttgagggtg gtggcggtgt gttctgccac gaagaagtac ataacccagc 8940
gtcgcaacgt ggattcgttg atatccccca aggcctcaag gcgctccatg gcctcgtaga 9000
agtccacggc gaagttgaaa aactgggagt tgcgcgccga cacggttaac tcctcctcca 9060
gaagacggat gagctcggcg acagtgtcgc gcacctcgcg ctcaaaggct acaggggcct 9120
cttcttcttc ttcaatctcc tcttccataa gggcctcccc ttcttcttct tctggcggcg 9180
gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg gaggcggtcg acaaagcgct 9240
cgatcatctc cccgcggcga cggcgcatgg tctcggtgac ggcgcggccg ttctcgcggg 9300
ggcgcagttg gaagacgccg cccgtcatgt cccggttatg ggttggcggg gggctgccat 9360
gcggcaggga tacggcgcta acgatgcatc tcaacaattg ttgtgtaggt actccgccgc 9420
cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa cctctcgaga aaggcgtcta 9480
accagtcaca gtcgcaaggt aggctgagca ccgtggcggg cggcagcggg cggcggtcgg 9540
ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa gtaggcggtc ttgagacggc 9600
ggatggtcga cagaagcacc atgtccttgg gtccggcctg ctgaatgcgc aggcggtcgg 9660
ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt gtagtagtct tgcatgagcc 9720
tttctaccgg cacttcttct tctccttcct cttgtcctgc atctcttgca tctatcgctg 9780
cggcggcggc ggagtttggc cgtaggtggc gccctcttcc tcccatgcgt gtgaccccga 9840
agcccctcat cggctgaagc agggctaggt cggcgacaac gcgctcggct aatatggcct 9900
gctgcacctg cgtgagggta gactggaagt catccatgtc cacaaagcgg tggtatgcgc 9960
ccgtgttgat ggtgtaagtg cagttggcca taacggacca gttaacggtc tggtgacccg 10020
gctgcgagag ctcggtgtac ctgagacgcg agtaagccct cgagtcaaat acgtagtcgt 10080
tgcaagtccg caccaggtac tggtatccca ccaaaaagtg cggcggcggc tggcggtaga 10140
ggggccagcg tagggtggcc ggggctccgg gggcgagatc ttccaacata aggcgatgat 10200
atccgtagat gtacctggac atccaggtga tgccggcggc ggtggtggag gcgcgcggaa 10260
agtcgcggac gcggttccag atgttgcgca gcggcaaaaa gtgctccatg gtcgggacgc 10320
tctggccggt caggcgcgcg caatcgttga cgctctagac cgtgcaaaag gagagcctgt 10380
aagcgggcac tcttccgtgg tctggtggat aaattcgcaa gggtatcatg gcggacgacc 10440
ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc 10500
gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc ttttggcttc cttccaggcg 10560
cggcggctgc tgcgctagct tttttggcca ctggccgcgc gcagcgtaag cggttaggct 10620
ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg agggttattt tccaagggtt 10680
gagtcgcggg acccccggtt cgagtctcgg accggccgga ctgcggcgaa cgggggtttg 10740
cctccccgtc atgcaagacc ccgcttgcaa attcctccgg aaacagggac gagccccttt 10800
tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg cccccctcct cagcagcggc 10860
aagagcaaga gcagcggcag acatgcaggg caccctcccc tcctcctacc gcgtcaggag 10920
gggcgacatc cgcggttgac gcggcagcag atggtgatta cgaacccccg cggcgccggg 10980
cccggcacta cctggacttg gaggagggcg agggcctggc gcggctagga gcgccctctc 11040
ctgagcggta cccaagggtg cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc 11100
agaacctgtt tcgcgaccgc gagggagagg agcccgagga gatgcgggat cgaaagttcc 11160
acgcagggcg cgagctgcgg catggcctga atcgcgagcg gttgctgcgc gaggaggact 11220
ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc 11280
tggtaaccgc atacgagcag acggtgaacc aggagattaa ctttcaaaaa agctttaaca 11340
accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat aggactgatg catctgtggg 11400
actttgtaag cgcgctggag caaaacccaa atagcaagcc gctcatggcg cagctgttcc 11460
ttatagtgca gcacagcagg gacaacgagg cattcaggga tgcgctgcta aacatagtag 11520
agcccgaggg ccgctggctg ctcgatttga taaacatcct gcagagcata gtggtgcagg 11580
agcgcagctt gagcctggct gacaaggtgg ccgccatcaa ctattccatg cttagcctgg 11640
gcaagtttta cgcccgcaag atataccata ccccttacgt tcccatagac aaggaggtaa 11700
agatcgaggg gttctacatg cgcatggcgc tgaaggtgct taccttgagc gacgacctgg 11760
gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt gagccggcgg cgcgagctca 11820
gcgaccgcga gctgatgcac agcctgcaaa gggccctggc tggcacgggc agcggcgata 11880
gagaggccga gtcctacttt gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg 11940
ccctggaggc agctggggcc ggacctgggc tggcggtggc acccgcgcgc gctggcaacg 12000
tcggcggcgt ggaggaatat gacgaggacg atgagtacga gccagaggac ggcgagtact 12060
aagcggtgat gtttctgatc agatgatgca agacgcaacg gacccggcgg tgcgggcggc 12120
gctgcagagc cagccgtccg gccttaactc cacggacgac tggcgccagg tcatggaccg 12180
catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg cagcagccgc aggccaaccg 12240
gctctccgca attctggaag cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt 12300
gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc cggcccgacg aggccggcct 12360
ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa 12420
cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg cagcgtgagc gcgcgcagca 12480
gcagggcaac ctgggctcca tggttgcact aaacgccttc ctgagtacac agcccgccaa 12540
cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc gcactgcggc taatggtgac 12600
tgagacaccg caaagtgagg tgtaccagtc tgggccagac tattttttcc agaccagtag 12660
acaaggcctg cagaccgtaa acctgagcca ggctttcaaa aacttgcagg ggctgtgggg 12720
ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg 12780
cctgttgctg ctgctaatag cgcccttcac ggacagtggc agcgtgtccc gggacacata 12840
cctaggtcac ttgctgacac tgtaccgcga ggccataggt caggcgcatg tggacgagca 12900
tactttccag gagattacaa gtgtcagccg cgcgctgggg caggaggaca cgggcagcct 12960
ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag aagatcccct cgttgcacag 13020
tttaaacagc gaggaggagc gcattttgcg ctacgtgcag cagagcgtga gccttaacct 13080
gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg accgcgcgca acatggaacc 13140
gggcatgtat gcctcaaacc ggccgtttat caaccgccta atggactact tgcatcgcgc 13200
ggccgccgtg aaccccgagt atttcaccaa tgccatcttg aacccgcact ggctaccgcc 13260
ccctggtttc tacaccgggg gattcgaggt gcccgagggt aacgatggat tcctctggga 13320
cgacatagac gacagcgtgt tttccccgca accgcagacc ctgctagagt tgcaacagcg 13380
cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc aggccaagca gcttgtccga 13440
tctaggcgct gcggccccgc ggtcagatgc tagtagccca tttccaagct tgatagggtc 13500
tcttaccagc actcgcacca cccgcccgcg cctgctgggc gaggaggagt acctaaacaa 13560
ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg gcatttccca acaacgggat 13620
agagagccta gtggacaaga tgagtagatg gaagacgtac gcgcaggagc acagggacgt 13680
gccaggcccg cgcccgccca cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg 13740
ggaggacgat gactcggcag acgacagcag cgtcctggat ttgggaggga gtggcaaccc 13800
gtttgcgcac cttcgcccca ggctggggag aatgttttaa aaaaaaaaaa gcatgatgca 13860
aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt tttcttgtat tccccttagt 13920
atgcggcgcg cggcgatgta tgaggaaggt cctcctccct cctacgagag tgtggtgagc 13980
gcggcgccag tggcggcggc gctgggttct cccttcgatg ctcccctgga cccgccgttt 14040
gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca gcatccgtta ctctgagttg 14100
gcacccctat tcgacaccac ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca 14160
tccctgaact accagaacga ccacagcaac tttctgacca cggtcattca aaacaatgac 14220
tacagcccgg gggaggcaag cacacagacc atcaatcttg acgaccggtc gcactggggc 14280
ggcgacctga aaaccatcct gcataccaac atgccaaatg tgaacgagtt catgtttacc 14340
aataagttta aggcgcgggt gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag 14400
ctgaaatacg agtgggtgga gttcacgctg cccgagggca actactccga gaccatgacc 14460
atagacctta tgaacaacgc gatcgtggag cactacttga aagtgggcag acagaacggg 14520
gttctggaaa gcgacatcgg ggtaaagttt gacacccgca acttcagact ggggtttgac 14580
cccgtcactg gtcttgtcat gcctggggta tatacaaacg aagccttcca tccagacatc 14640
attttgctgc caggatgcgg ggtggacttc acccacagcc gcctgagcaa cttgttgggc 14700
atccgcaagc ggcaaccctt ccaggagggc tttaggatca cctacgatga tctggagggt 14760
ggtaacattc ccgcactgtt ggatgtggac gcctaccagg cgagcttgaa agatgacacc 14820
gaacagggcg ggggtggcgc aggcggcagc aacagcagtg gcagcggcgc ggaagagaac 14880
tccaacgcgg cagccgcggc aatgcagccg gtggaggaca tgaacgatca tgccattcgc 14940
ggcgacacct ttgccacacg ggctgaggag aagcgcgctg aggccgaagc agcggccgaa 15000
gctgccgccc ccgctgcgca acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa 15060
cccctgacag aggacagcaa gaaacgcagt tacaacctaa taagcaatga cagcaccttc 15120
acccagtacc gcagctggta ccttgcatac aactacggcg accctcagac cggaatccgc 15180
tcatggaccc tgctttgcac tcctgacgta acctgcggct cggagcaggt ctactggtcg 15240
ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca cgcgccagat cagcaacttt 15300
ccggtggtgg gcgccgagct gttgcccgtg cactccaaga gcttctacaa cgaccaggcc 15360
gtctactccc aactcatccg ccagtttacc tctctgaccc acgtgttcaa tcgctttccc 15420
gagaaccaga ttttggcgcg cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt 15480
cctgctctca cagatcacgg gacgctaccg ctgcgcaaca gcatcggagg agtccagcga 15540
gtgaccatta ctgacgccag acgccgcacc tgcccctacg tttacaaggc cctgggcata 15600
gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa gcatgtccat ccttatatcg 15660
cccagcaata acacaggctg gggcctgcgc ttcccaagca agatgtttgg cggggccaag 15720
aagcgctccg accaacaccc agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg 15780
cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag 15840
gaggcgcgca actacacgcc cacgccgcca ccagtgtcca cagtggacgc ggccattcag 15900
accgtggtgc gcggagcccg gcgctatgct aaaatgaaga gacggcggag gcgcgtagca 15960
cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg cggcggcggc cctgcttaac 16020
cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt 16080
attgtcactg tgccccccag gtccaggcga cgagcggccg ccgcagcagc cgcggccatt 16140
agtgctatga ctcagggtcg caggggcaac gtgtattggg tgcgcgactc ggttagcggc 16200
ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga ttgcaagaaa aaactactta 16260
gactcgtact gttgtatgta tccagcggcg gcggcgcgca acgaagctat gtccaagcgc 16320
aaaatcaaag aagagatgct ccaggtcatc gcgccggaga tctatggccc cccgaagaag 16380
gaagagcagg attacaagcc ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat 16440
gatgatgaac ttgacgacga ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta 16500
cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg 16560
cccggtgagc gctccacccg cacctacaag cgcgtgtatg atgaggtgta cggcgacgag 16620
gacctgcttg agcaggccaa cgagcgcctc ggggagtttg cctacggaaa gcggcataag 16680
gacatgctgg cgttgccgct ggacgagggc aacccaacac ctagcctaaa gcccgtaaca 16740
ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag 16800
tctggtgact tggcacccac cgtgcagctg atggtaccca agcgccagcg actggaagat 16860
gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg aggtccgcgt gcggccaatc 16920
aagcaggtgg cgccgggact gggcgtgcag accgtggacg ttcagatacc cactaccagt 16980
agcaccagta ttgccaccgc cacagagggc atggagacac aaacgtcccc ggttgcctca 17040
gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg cgtccaagac ctctacggag 17100
gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc ggcgcccgcg cggttcgagg 17160
aagtacggcg ccgccagcgc gctactgccc gaatatgccc tacatccttc cattgcgcct 17220
acccccggct atcgtggcta cacctaccgc cccagaagac gagcaactac ccgacgccga 17280
accaccactg gaacccgccg ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc 17340
gtgcgcaggg tggctcgcga aggaggcagg accctggtgc tgccaacagc gcgctaccac 17400
cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag atatggccct cacctgccgc 17460
ctccgtttcc cggtgccggg attccgagga agaatgcacc gtaggagggg catggccggc 17520
cacggcctga cgggcggcat gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt 17580
cgcatgcgcg gcggtatcct gcccctcctt attccactga tcgccgcggc gattggcgcc 17640
gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac actgattaaa aacaagttgc 17700
atgtggaaaa atcaaaataa aaagtctgga ctctcacgct cgcttggtcc tgtaactatt 17760
ttgtagaatg gaagacatca actttgcgtc tctggccccg cgacacggct cgcgcccgtt 17820
catgggaaac tggcaagata tcggcaccag caatatgagc ggtggcgcct tcagctgggg 17880
ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc 17940
ctggaacagc agcacaggcc agatgctgag ggataagttg aaagagcaaa atttccaaca 18000
aaaggtggta gatggcctgg cctctggcat tagcggggtg gtggacctgg ccaaccaggc 18060
agtgcaaaat aagattaaca gtaagcttga tccccgccct cccgtagagg agcctccacc 18120
ggccgtggag acagtgtctc cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga 18180
agaaactctg gtgacgcaaa tagacgagcc tccctcgtac gaggaggcac taaagcaagg 18240
cctgcccacc acccgtccca tcgcgcccat ggctaccgga gtgctgggcc agcacacacc 18300
cgtaacgctg gacctgcctc cccccgccga cacccagcag aaacctgtgc tgccaggccc 18360
gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc 18420
gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg 18480
tctgggggtg caatccctga agcgccgacg atgcttctga atagctaacg tgtcgtatgt 18540
gtgtcatgta tgcgtccatg tcgccgccag aggagctgct gagccgccgc gcgcccgctt 18600
tccaagatgg ctaccccttc gatgatgccg cagtggtctt acatgcacat ctcgggccag 18660
gacgcctcgg agtacctgag ccccgggctg gtgcagtttg cccgcgccac cgagacgtac 18720
ttcagcctga ataacaagtt tagaaacccc acggtggcgc ctacgcacga cgtgaccaca 18780
gaccggtccc agcgtttgac gctgcggttc atccctgtgg accgtgagga tactgcgtac 18840
tcgtacaagg cgcggttcac cctagctgtg ggtgataacc gtgtgctgga catggcttcc 18900
acgtactttg acatccgcgg cgtgctggac aggggcccta cttttaagcc ctactctggc 18960
actgcctaca acgccctggc tcccaagggt gccccaaatc cttgcgaatg ggatgaagct 19020
gctactgctc ttgaaataaa cctagaagaa gaggacgatg acaacgaaga cgaagtagac 19080
gagcaagctg agcagcaaaa aactcacgta tttgggcagg cgccttattc tggtataaat 19140
attacaaagg agggtattca aataggtgtc gaaggtcaaa cacctaaata tgccgataaa 19200
acatttcaac ctgaacctca aataggagaa tctcagtggt acgaaactga aattaatcat 19260
gcagctggga gagtccttaa aaagactacc ccaatgaaac catgttacgg ttcatatgca 19320
aaacccacaa atgaaaatgg agggcaaggc attcttgtaa agcaacaaaa tggaaagcta 19380
gaaagtcaag tggaaatgca atttttctca actactgagg cgaccgcagg caatggtgat 19440
aacttgactc ctaaagtggt attgtacagt gaagatgtag atatagaaac cccagacact 19500
catatttctt acatgcccac tattaaggaa ggtaactcac gagaactaat gggccaacaa 19560
tctatgccca acaggcctaa ttacattgct tttagggaca attttattgg tctaatgtat 19620
tacaacagca cgggtaatat gggtgttctg gcgggccaag catcgcagtt gaatgctgtt 19680
gtagatttgc aagacagaaa cacagagctt tcataccagc ttttgcttga ttccattggt 19740
gatagaacca ggtacttttc tatgtggaat caggctgttg acagctatga tccagatgtt 19800
agaattattg aaaatcatgg aactgaagat gaacttccaa attactgctt tccactggga 19860
ggtgtgatta atacagagac tcttaccaag gtaaaaccta aaacaggtca ggaaaatgga 19920
tgggaaaaag atgctacaga attttcagat aaaaatgaaa taagagttgg aaataatttt 19980
gccatggaaa tcaatctaaa tgccaacctg tggagaaatt tcctgtactc caacatagcg 20040
ctgtatttgc ccgacaagct aaagtacagt ccttccaacg taaaaatttc tgataaccca 20100
aacacctacg actacatgaa caagcgagtg gtggctcccg ggttagtgga ctgctacatt 20160
aaccttggag cacgctggtc ccttgactat atggacaacg tcaacccatt taaccaccac 20220
cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca atggtcgcta tgtgcccttc 20280
cacatccagg tgcctcagaa gttctttgcc attaaaaacc tccttctcct gccgggctca 20340
tacacctacg agtggaactt caggaaggat gttaacatgg ttctgcagag ctccctagga 20400
aatgacctaa gggttgacgg agccagcatt aagtttgata gcatttgcct ttacgccacc 20460
ttcttcccca tggcccacaa caccgcctcc acgcttgagg ccatgcttag aaacgacacc 20520
aacgaccagt cctttaacga ctatctctcc gccgccaaca tgctctaccc tatacccgcc 20580
aacgctacca acgtgcccat atccatcccc tcccgcaact gggcggcttt ccgcggctgg 20640
gccttcacgc gccttaagac taaggaaacc ccatcactgg gctcgggcta cgacccttat 20700
tacacctact ctggctctat accctaccta gatggaacct tttacctcaa ccacaccttt 20760
aagaaggtgg ccattacctt tgactcttct gtcagctggc ctggcaatga ccgcctgctt 20820
acccccaacg agtttgaaat taagcgctca gttgacgggg agggttacaa cgttgcccag 20880
tgtaacatga ccaaagactg gttcctggta caaatgctag ctaactacaa cattggctac 20940
cagggcttct atatcccaga gagctacaag gaccgcatgt actccttctt tagaaacttc 21000
cagcccatga gccgtcaggt ggtggatgat actaaataca aggactacca acaggtgggc 21060
atcctacacc aacacaacaa ctctggattt gttggctacc ttgcccccac catgcgcgaa 21120
ggacaggcct accctgctaa cttcccctat ccgcttatag gcaagaccgc agttgacagc 21180
attacccaga aaaagtttct ttgcgatcgc accctttggc gcatcccatt ctccagtaac 21240
tttatgtcca tgggcgcact cacagacctg ggccaaaacc ttctctacgc caactccgcc 21300
cacgcgctag acatgacttt tgaggtggat cccatggacg agcccaccct tctttatgtt 21360
ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc accgcggcgt catcgaaacc 21420
gtgtacctgc gcacgccctt ctcggccggc aacgccacaa cataaagaag caagcaacat 21480
caacaacagc tgccgccatg ggctccagtg agcaggaact gaaagccatt gtcaaagatc 21540
ttggttgtgg gccatatttt ttgggcacct atgacaagcg ctttccaggc tttgtttctc 21600
cacacaagct cgcctgcgcc atagtcaata cggccggtcg cgagactggg ggcgtacact 21660
ggatggcctt tgcctggaac ccgcactcaa aaacatgcta cctctttgag ccctttggct 21720
tttctgacca gcgactcaag caggtttacc agtttgagta cgagtcactc ctgcgccgta 21780
gcgccattgc ttcttccccc gaccgctgta taacgctgga aaagtccacc caaagcgtac 21840
aggggcccaa ctcggccgcc tgtggactat tctgctgcat gtttctccac gcctttgcca 21900
actggcccca aactcccatg gatcacaacc ccaccatgaa ccttattacc ggggtaccca 21960
actccatgct caacagtccc caggtacagc ccaccctgcg tcgcaaccag gaacagctct 22020
acagcttcct ggagcgccac tcgccctact tccgcagcca cagtgcgcag attaggagcg 22080
ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg tactagagac actttcaata 22140
aaggcaaatg cttttatttg tacactctcg ggtgattatt tacccccacc cttgccgtct 22200
gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct atgcgccact ggcagggaca 22260
cgttgcgata ctggtgttta gtgctccact taaactcagg cacaaccatc cgcggcagct 22320
cggtgaagtt ttcactccac aggctgcgca ccatcaccaa cgcgtttagc aggtcgggcg 22380
ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc gcgcgagttg cgatacacag 22440
ggttgcagca ctggaacact atcagcgccg ggtggtgcac gctggccagc acgctcttgt 22500
cggagatcag atccgcgtcc aggtcctccg cgttgctcag ggcgaacgga gtcaactttg 22560
gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga gttgcactcg caccgtagtg 22620
gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata cagcgcctgc ataaaagcct 22680
tgatctgctt aaaagccacc tgagcctttg cgccttcaga gaagaacatg ccgcaagact 22740
tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac gcagcacctt gcgtcggtgt 22800
tggagatctg caccacattt cggccccacc ggttcttcac gatcttggcc ttgctagact 22860
gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc catttcaatc acgtgctcct 22920
tatttatcat aatgcttccg tgtagacact taagctcgcc ttcgatctca gcgcagcggt 22980
gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta ggtcacctct gcaaacgact 23040
gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa ggtcttgttg ctggtgaagg 23100
tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt gcatacggcc gccagagctt 23160
ccacttggtc aggcagtagt ttgaagttcg cctttagatc gttatccacg tggtacttgt 23220
ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc agacacgatc ggcacactca 23280
gcgggttcat caccgtaatt tcactttccg cttcgctggg ctcttcctct tcctcttgcg 23340
tccgcatacc acgcgccact gggtcgtctt cattcagccg ccgcactgtg cgcttacctc 23400
ctttgccatg cttgattagc accggtgggt tgctgaaacc caccatttgt agcgccacat 23460
cttctctttc ttcctcgctg tccacgatta cctctggtga tggcgggcgc tcgggcttgg 23520
gagaagggcg cttctttttc ttcttgggcg caatggccaa atccgccgcc gaggtcgatg 23580
gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga tgagtcttcc tcgtcctcgg 23640
actcgatacg ccgcctcatc cgcttttttg ggggcgcccg gggaggcggc ggcgacgggg 23700
acggggacga cacgtcctcc atggttgggg gacgtcgcgc cgcaccgcgt ccgcgctcgg 23760
gggtggtttc gcgctgctcc tcttcccgac tggccatttc cttctcctat aggcagaaaa 23820
agatcatgga gtcagtcgag aagaaggaca gcctaaccgc cccctctgag ttcgccacca 23880
ccgcctccac cgatgccgcc aacgcgccta ccaccttccc cgtcgaggca cccccgcttg 23940
aggaggagga agtgattatc gagcaggacc caggttttgt aagcgaagac gacgaggacc 24000
gctcagtacc aacagaggat aaaaagcaag accaggacaa cgcagaggca aacgaggaac 24060
aagtcgggcg gggggacgaa aggcatggcg actacctaga tgtgggagac gacgtgctgt 24120
tgaagcatct gcagcgccag tgcgccatta tctgcgacgc gttgcaagag cgcagcgatg 24180
tgcccctcgc catagcggat gtcagccttg cctacgaacg ccacctattc tcaccgcgcg 24240
taccccccaa acgccaagaa aacggcacat gcgagcccaa cccgcgcctc aacttctacc 24300
ccgtatttgc cgtgccagag gtgcttgcca cctatcacat ctttttccaa aactgcaaga 24360
tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa gcagctggcc ttgcggcagg 24420
gcgctgtcat acctgatatc gcctcgctca acgaagtgcc aaaaatcttt gagggtcttg 24480
gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga aaacagcgaa aatgaaagtc 24540
actctggagt gttggtggaa ctcgagggtg acaacgcgcg cctagccgta ctaaaacgca 24600
gcatcgaggt cacccacttt gcctacccgg cacttaacct accccccaag gtcatgagca 24660
cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct ggagagggat gcaaatttgc 24720
aagaacaaac agaggagggc ctacccgcag ttggcgacga gcagctagcg cgctggcttc 24780
aaacgcgcga gcctgccgac ttggaggagc gacgcaaact aatgatggcc gcagtgctcg 24840
ttaccgtgga gcttgagtgc atgcagcggt tctttgctga cccggagatg cagcgcaagc 24900
tagaggaaac attgcactac acctttcgac agggctacgt acgccaggcc tgcaagatct 24960
ccaacgtgga gctctgcaac ctggtctcct accttggaat tttgcacgaa aaccgccttg 25020
ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg ccgcgactac gtccgcgact 25080
gcgtttactt atttctatgc tacacctggc agacggccat gggcgtttgg cagcagtgct 25140
tggaggagtg caacctcaag gagctgcaga aactgctaaa gcaaaacttg aaggacctat 25200
ggacggcctt caacgagcgc tccgtggccg cgcacctggc ggacatcatt ttccccgaac 25260
gcctgcttaa aaccctgcaa cagggtctgc cagacttcac cagtcaaagc atgttgcaga 25320
actttaggaa ctttatccta gagcgctcag gaatcttgcc cgccacctgc tgtgcacttc 25380
ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc gccgctttgg ggccactgct 25440
accttctgca gctagccaac taccttgcct accactctga cataatggaa gacgtgagcg 25500
gtgacggtct actggagtgt cactgtcgct gcaacctatg caccccgcac cgctccctgg 25560
tttgcaattc gcagctgctt aacgaaagtc aaattatcgg tacctttgag ctgcagggtc 25620
cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact cactccgggg ctgtggacgt 25680
cggcttacct tcgcaaattt gtacctgagg actaccacgc ccacgagatt aggttctacg 25740
aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg cgtcattacc cagggccaca 25800
ttcttggcca attgcaagcc atcaacaaag cccgccaaga gtttctgcta cgaaagggac 25860
ggggggttta cttggacccc cagtccggcg aggagctcaa cccaatcccc ccgccgccgc 25920
agccctatca gcagcagccg cgggcccttg cttcccagga tggcacccaa aaagaagctg 25980
cagctgccgc cgccacccac ggacgaggag gaatactggg acagtcaggc agaggaggtt 26040
ttggacgagg aggaggagga catgatggaa gactgggaga gcctagacga ggaagcttcc 26100
gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg tcgcattccc ctcgccggcg 26160
ccccagaaat cggcaaccgg ttccagcatg gctacaacct ccgctcctca ggcgccgccg 26220
gcactgcccg ttcgccgacc caaccgtaga tgggacacca ctggaaccag ggccggtaag 26280
tccaagcagc cgccgccgtt agcccaagag caacaacagc gccaaggcta ccgctcatgg 26340
cgcgggcaca agaacgccat agttgcttgc ttgcaagact gtgggggcaa catctccttc 26400
gcccgccgct ttcttctcta ccatcacggc gtggccttcc cccgtaacat cctgcattac 26460
taccgtcatc tctacagccc atactgcacc ggcggcagcg gcagcggcag caacagcagc 26520
ggccacacag aagcaaaggc gaccggatag caagactctg acaaagccca agaaatccac 26580
agcggcggca gcagcaggag gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac 26640
ccgcgagctt agaaacagga tttttcccac tctgtatgct atatttcaac agagcagggg 26700
ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga tccctcaccc gcagctgcct 26760
gtatcacaaa agcgaagatc agcttcggcg cacgctggaa gacgcggagg ctctcttcag 26820
taaatactgc gcgctgactc ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg 26880
aaaactacgt catctccagc ggccacaccc ggcgccagca cctgtcgtca gcgccattat 26940
gagcaaggaa attcccacgc cctacatgtg gagttaccag ccacaaatgg gacttgcggc 27000
tggagctgcc caagactact caacccgaat aaactacatg agcgcgggac cccacatgat 27060
atcccgggtc aacggaatcc gcgcccaccg aaaccgaatt ctcttggaac aggcggctat 27120
taccaccaca cctcgtaata accttaatcc ccgtagttgg cccgctgccc tggtgtacca 27180
ggaaagtccc gctcccacca ctgtggtact tcccagagac gcccaggccg aagttcagat 27240
gactaactca ggggcgcagc ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca 27300
gggtataact cacctgacaa tcagagggcg aggtattcag ctcaacgacg agtcggtgag 27360
ctcctcgctt ggtctccgtc cggacgggac atttcagatc ggcggcgccg gccgtccttc 27420
attcacgcct cgtcaggcaa tcctaactct gcagacctcg tcctctgagc cgcgctctgg 27480
aggcattgga actctgcaat ttattgagga gtttgtgcca tcggtctact ttaacccctt 27540
ctcgggacct cccggccact atccggatca atttattcct aactttgacg cggtaaagga 27600
ctcggcggac ggctacgact gaatgttaag tggagaggca gagcaactgc gcctgaaaca 27660
cctggtccac tgtcgccgcc acaagtgctt tgcccgcgac tccggtgagt tttgctactt 27720
tgaattgccc gaggatcata tcgagggccc ggcgcacggc gtccggctta ccgcccaggg 27780
agagcttgcc cgtagcctga ttcgggagtt tacccagcgc cccctgctag ttgagcggga 27840
caggggaccc tgtgttctca ctgtgatttg caactgtcct aaccttggat tacatcaaga 27900
tctttgttgc catctctgtg ctgagtataa taaatacaga aattaaaata tactggggct 27960
cctatcgcca tcctgtaaac gccaccgtct tcacccgccc aagcaaacca aggcgaacct 28020
tacctggtac ttttaacatc tctccctctg tgatttacaa cagtttcaac ccagacggag 28080
tgagtctacg agagaacctc tccgagctca gctactccat cagaaaaaac accaccctcc 28140
ttacctgccg ggaacgtacg agtgcgtcac cggccgctgc accacaccta ccgcctgacc 28200
gtaaaccaga ctttttccgg acagacctca ataactctgt ttaccagaac aggaggtgag 28260
cttagaaaac ccttagggta ttaggccaaa ggcgcagcta ctgtggggtt tatgaacaat 28320
tcaagcaact ctacgggcta ttctaattca ggtttctcta gaaatggacg gaattattac 28380
agagcagcgc ctgctagaaa gacgcagggc agcggccgag caacagcgca tgaatcaaga 28440
gctccaagac atggttaact tgcaccagtg caaaaggggt atcttttgtc tggtaaagca 28500
ggccaaagtc acctacgaca gtaataccac cggacaccgc cttagctaca agttgccaac 28560
caagcgtcag aaattggtgg tcatggtggg agaaaagccc attaccataa ctcagcactc 28620
ggtagaaacc gaaggctgca ttcactcacc ttgtcaagga cctgaggatc tctgcaccct 28680
tattaagacc ctgtgcggtc tcaaagatct tattcccttt aactaataaa aaaaaataat 28740
aaagcatcac ttacttaaaa tcagttagca aatttctgtc cagtttattc agcagcacct 28800
ccttgccctc ctcccagctc tggtattgca gcttcctcct ggctgcaaac tttctccaca 28860
atctaaatgg aatgtcagtt tcctcctgtt cctgtccatc cgcacccact atcttcatgt 28920
tgttgcagat gaagcgcgca agaccgtctg aagatacctt caaccccgtg tatccatatg 28980
acacggaaac cggtcctcca actgtgcctt ttcttactcc tccctttgta tcccccaatg 29040
ggtttcaaga gagtccccct ggggtactct ctttgcgcct atccgaacct ctagttacct 29100
ccaatggcat gcttgcgctc aaaatgggca acggcctctc tctggacgag gccggcaacc 29160
ttacctccca aaatgtaacc actgtgagcc cacctctcaa aaaaaccaag tcaaacataa 29220
acctggaaat atctgcaccc ctcacagtta cctcagaagc cctaactgtg gctgccgccg 29280
cacctctaat ggtcgcgggc aacacactca ccatgcaatc acaggccccg ctaaccgtgc 29340
acgactccaa acttagcatt gccacccaag gacccctcac agtgtcagaa ggaaagctag 29400
ccctgcaaac atcaggcccc ctcaccacca ccgatagcag tacccttact atcactgcct 29460
caccccctct aactactgcc actggtagct tgggcattga cttgaaagag cccatttata 29520
cacaaaatgg aaaactagga ctaaagtacg gggctccttt gcatgtaaca gacgacctaa 29580
acactttgac cgtagcaact ggtccaggtg tgactattaa taatacttcc ttgcaaacta 29640
aagttactgg agccttgggt tttgattcac aaggcaatat gcaacttaat gtagcaggag 29700
gactaaggat tgattctcaa aacagacgcc ttatacttga tgttagttat ccgtttgatg 29760
ctcaaaacca actaaatcta agactaggac agggccctct ttttataaac tcagcccaca 29820
acttggatat taactacaac aaaggccttt acttgtttac agcttcaaac aattccaaaa 29880
agcttgaggt taacctaagc actgccaagg ggttgatgtt tgacgctaca gccatagcca 29940
ttaatgcagg agatgggctt gaatttggtt cacctaatgc accaaacaca aatcccctca 30000
aaacaaaaat tggccatggc ctagaatttg attcaaacaa ggctatggtt cctaaactag 30060
gaactggcct tagttttgac agcacaggtg ccattacagt aggaaacaaa aataatgata 30120
agctaacttt gtggaccaca ccagctccat ctcctaactg tagactaaat gcagagaaag 30180
atgctaaact cactttggtc ttaacaaaat gtggcagtca aatacttgct acagtttcag 30240
ttttggctgt taaaggcagt ttggctccaa tatctggaac agttcaaagt gctcatctta 30300
ttataagatt tgacgaaaat ggagtgctac taaacaattc cttcctggac ccagaatatt 30360
ggaactttag aaatggagat cttactgaag gcacagccta tacaaacgct gttggattta 30420
tgcctaacct atcagcttat ccaaaatctc acggtaaaac tgccaaaagt aacattgtca 30480
gtcaagttta cttaaacgga gacaaaacta aacctgtaac actaaccatt acactaaacg 30540
gtacacagga aacaggagac acaactccaa gtgcatactc tatgtcattt tcatgggact 30600
ggtctggcca caactacatt aatgaaatat ttgccacatc ctcttacact ttttcataca 30660
ttgcccaaga ataaagaatc gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag 30720
aaaatttcga atcatttttc attcagtagt atagccccac caccacatag cttatacaga 30780
tcaccgtacc ttaatcaaac tcacagaacc ctagtattca acctgccacc tccctcccaa 30840
cacacagagt acacagtcct ttctccccgg ctggccttaa aaagcatcat atcatgggta 30900
acagacatat tcttaggtgt tatattccac acggtttcct gtcgagccaa acgctcatca 30960
gtgatattaa taaactcccc gggcagctca cttaagttca tgtcgctgtc cagctgctga 31020
gccacaggct gctgtccaac ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc 31080
tacatggggg tagagtcata atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg 31140
cgaataaact gctgccgccg ccgctccgtc ctgcaggaat acaacatggc agtggtctcc 31200
tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg tcctccgggc acagcagcgc 31260
accctgatct cacttaaatc agcacagtaa ctgcagcaca gcaccacaat attgttcaaa 31320
atcccacagt gcaaggcgct gtatccaaag ctcatggcgg ggaccacaga acccacgtgg 31380
ccatcatacc acaagcgcag gtagattaag tggcgacccc tcataaacac gctggacata 31440
aacattacct cttttggcat gttgtaattc accacctccc ggtaccatat aaacctctga 31500
ttaaacatgg cgccatccac caccatccta aaccagctgg ccaaaacctg cccgccggct 31560
atacactgca gggaaccggg actggaacaa tgacagtgga gagcccagga ctcgtaacca 31620
tggatcatca tgctcgtcat gatatcaatg ttggcacaac acaggcacac gtgcatacac 31680
ttcctcagga ttacaagctc ctcccgcgtt agaaccatat cccagggaac aacccattcc 31740
tgaatcagcg taaatcccac actgcaggga agacctcgca cgtaactcac gttgtgcatt 31800
gtcaaagtgt tacattcggg cagcagcgga tgatcctcca gtatggtagc gcgggtttct 31860
gtctcaaaag gaggtagacg atccctactg tacggagtgc gccgagacaa ccgagatcgt 31920
gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa 31980
ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct cgccgcttag atcgctctgt 32040
gtagtagttg tagtatatcc actctctcaa agcatccagg cgccccctgg cttcgggttc 32100
tatgtaaact ccttcatgcg ccgctgccct gataacatcc accaccgcag aataagccac 32160
acccagccaa cctacacatt cgttctgcga gtcacacacg ggaggagcgg gaagagctgg 32220
aagaaccatg tttttttttt tattccaaaa gattatccaa aacctcaaaa tgaagatcta 32280
ttaagtgaac gcgctcccct ccggtggcgt ggtcaaactc tacagccaaa gaacagataa 32340
tggcatttgt aagatgttgc acaatggctt ccaaaaggca aacggccctc acgtccaagt 32400
ggacgtaaag gctaaaccct tcagggtgaa tctcctctat aaacattcca gcaccttcaa 32460
ccatgcccaa ataattctca tctcgccacc ttctcaatat atctctaagc aaatcccgaa 32520
tattaagtcc ggccattgta aaaatctgct ccagagcgcc ctccaccttc agcctcaagc 32580
agcgaatcat gattgcaaaa attcaggttc ctcacagacc tgtataagat tcaaaagcgg 32640
aacattaaca aaaataccgc gatcccgtag gtcccttcgc agggccagct gaacataatc 32700
gtgcaggtct gcacggacca gcgcggccac ttccccgcca ggaaccttga caaaagaacc 32760
cacactgatt atgacacgca tactcggagc tatgctaacc agcgtagccc cgatgtaagc 32820
tttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct 32880
cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg 32940
gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa 33000
acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa 33060
aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg 33120
gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta 33180
agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata 33240
gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat 33300
aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa 33360
aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt 33420
cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct 33480
caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa 33540
tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca 33600
gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta 33660
cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa 33720
aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca 33780
ttatcatatt ggcttcaatc caaaataagg tatattattg atgatgttaa ttaagggcgg 33840
ccgcacgggc catcgatggg gatccatccg cggagaagct tctcgaccaa ttctcatgtt 33900
tgacagctta tcatcgaatt tctgccattc atccgcttat tatcacttat tcaggcgtag 33960
caaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac 34020
tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg 34080
gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg 34140
cccatggtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg 34200
gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg 34260
aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc 34320
cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa 34380
acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata 34440
cggaattccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac 34500
ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg 34560
ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg 34620
gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct 34680
gaaaatctcg ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag 34740
ttggaacctc ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc 34800
ccggtatcaa cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt 34860
atttattcgc gataagctca tggagcggcg taaccgtcgc acaggaagga cagagaaagc 34920
gcggatctgg gaagtgacgg acagaacggt caggacctgg attggggagg cggttgccgc 34980
cgctgctgct gacggtgtga cgttctctgt tccggtcaca ccacatacgt tccgccattc 35040
ctatgcgatg cacatgctgt atgccggtat accgctgaaa gttctgcaaa gcctgatggg 35100
acataagtcc atcagttcaa cggaagtcta cacgaaggtt tttgcgctgg atgtggctgc 35160
ccggcaccgg gtgcagtttg cgatgccgga gtctgatgcg gttgcgatgc tgaaacaatt 35220
atcctgagaa taaatgcctt ggcctttata tggaaatgtg gaactgagtg gatatgctgt 35280
ttttgtctgt taaacagaga agctggctgt tatccactga gaagcgaacg aaacagtcgg 35340
gaaaatctcc cattatcgta gagatccgca ttattaatct caggagcctg tgtagcgttt 35400
ataggaagta gtgttctgtc atgatgcctg caagcggtaa cgaaaacgat ttgaatatgc 35460
cttcaggaac aatagaaatc ttcgtgcggt gttacgttga agtggagcgg attatgtcag 35520
caatggacag aacaacctaa tgaacacaga accatgatgt ggtctgtcct tttacagcca 35580
gtaggctcgc cgcagtcgag cgacggcgaa gccctcgagt gagcgaggaa gcaccaggga 35640
acagcactta tatattctgc ttacacacga tgcctgaaaa aacttccctt ggggttatcc 35700
acttatccac ggggatattt ttataattat tttttttata gtttttagat cttctttttt 35760
agagcgcctt gtaggccttt atccatgctg gttctagaga aggtgttgtg acaaattgcc 35820
ctttcagtgt gacaaatcac cctcaaatga cagtcctgtc tgtgacaaat tgcccttaac 35880
cctgtgacaa attgccctca gaagaagctg ttttttcaca aagttatccc tgcttattga 35940
ctctttttta tttagtgtga caatctaaaa acttgtcaca cttcacatgg atctgtcatg 36000
gcggaaacag cggttatcaa tcacaagaaa cgtaaaaata gcccgcgaat cgtccagtca 36060
aacgacctca ctgaggcggc atatagtctc tcccgggatc aaaaacgtat gctgtatctg 36120
ttcgttgacc agatcagaaa atctgatggc accctacagg aacatgacgg tatctgcgag 36180
atccatgttg ctaaatatgc tgaaatattc ggattgacct ctgcggaagc cagtaaggat 36240
atacggcagg cattgaagag tttcgcgggg aaggaagtgg ttttttatcg ccctgaagag 36300
gatgccggcg atgaaaaagg ctatgaatct tttccttggt ttatcaaacg tgcgcacagt 36360
ccatccagag ggctttacag tgtacatatc aacccatatc tcattccctt ctttatcggg 36420
ttacagaacc ggtttacgca gtttcggctt agtgaaacaa aagaaatcac caatccgtat 36480
gccatgcgtt tatacgaatc cctgtgtcag tatcgtaagc cggatggctc aggcatcgtc 36540
tctctgaaaa tcgactggat catagagcgt taccagctgc ctcaaagtta ccagcgtatg 36600
cctgacttcc gccgccgctt cctgcaggtc tgtgttaatg agatcaacag cagaactcca 36660
atgcgcctct catacattga gaaaaagaaa ggccgccaga cgactcatat cgtattttcc 36720
ttccgcgata tcacttccat gacgacagga tagtctgagg gttatctgtc acagatttga 36780
gggtggttcg tcacatttgt tctgacctac tgagggtaat ttgtcacagt tttgctgttt 36840
ccttcagcct gcatggattt tctcatactt tttgaactgt aatttttaag gaagccaaat 36900
ttgagggcag tttgtcacag ttgatttcct tctctttccc ttcgtcatgt gacctgatat 36960
cgggggttag ttcgtcatca ttgatgaggg ttgattatca cagtttatta ctctgaattg 37020
gctatccgcg tgtgtacctc tacctggagt ttttcccacg gtggatattt cttcttgcgc 37080
tgagcgtaag agctatctga cagaacagtt cttctttgct tcctcgccag ttcgctcgct 37140
atgctcggtt acacggctgc ggcgagcgct agtgataata agtgactgag gtatgtgctc 37200
ttcttatctc cttttgtagt gttgctctta ttttaaacaa ctttgcggtt ttttgatgac 37260
tttgcgattt tgttgttgct ttgcagtaaa ttgcaagatt taataaaaaa acgcaaagca 37320
atgattaaag gatgttcaga atgaaactca tggaaacact taaccagtgc ataaacgctg 37380
gtcatgaaat gacgaaggct atcgccattg cacagtttaa tgatgacagc ccggaagcga 37440
ggaaaataac ccggcgctgg agaataggtg aagcagcgga tttagttggg gtttcttctc 37500
aggctatcag agatgccgag aaagcagggc gactaccgca cccggatatg gaaattcgag 37560
gacgggttga gcaacgtgtt ggttatacaa ttgaacaaat taatcatatg cgtgatgtgt 37620
ttggtacgcg attgcgacgt gctgaagacg tatttccacc ggtgatcggg gttgctgccc 37680
ataaaggtgg cgtttacaaa acctcagttt ctgttcatct tgctcaggat ctggctctga 37740
aggggctacg tgttttgctc gtggaaggta acgaccccca gggaacagcc tcaatgtatc 37800
acggatgggt accagatctt catattcatg cagaagacac tctcctgcct ttctatcttg 37860
gggaaaagga cgatgtcact tatgcaataa agcccacttg ctggccgggg cttgacatta 37920
ttccttcctg tctggctctg caccgtattg aaactgagtt aatgggcaaa tttgatgaag 37980
gtaaactgcc caccgatcca cacctgatgc tccgactggc cattgaaact gttgctcatg 38040
actatgatgt catagttatt gacagcgcgc ctaacctggg tatcggcacg attaatgtcg 38100
tatgtgctgc tgatgtgctg attgttccca cgcctgctga gttgtttgac tacacctccg 38160
cactgcagtt tttcgatatg cttcgtgatc tgctcaagaa cgttgatctt aaagggttcg 38220
agcctgatgt acgtattttg cttaccaaat acagcaatag taatggctct cagtccccgt 38280
ggatggagga gcaaattcgg gatgcctggg gaagcatggt tctaaaaaat gttgtacgtg 38340
aaacggatga agttggtaaa ggtcagatcc ggatgagaac tgtttttgaa caggccattg 38400
atcaacgctc ttcaactggt gcctggagaa atgctctttc tatttgggaa cctgtctgca 38460
atgaaatttt cgatcgtctg attaaaccac gctgggagat tagataatga agcgtgcgcc 38520
tgttattcca aaacatacgc tcaatactca accggttgaa gatacttcgt tatcgacacc 38580
agctgccccg atggtggatt cgttaattgc gcgcgtagga gtaatggctc gcggtaatgc 38640
cattactttg cctgtatgtg gtcgggatgt gaagtttact cttgaagtgc tccggggtga 38700
tagtgttgag aagacctctc gggtatggtc aggtaatgaa cgtgaccagg agctgcttac 38760
tgaggacgca ctggatgatc tcatcccttc ttttctactg actggtcaac agacaccggc 38820
gttcggtcga agagtatctg gtgtcataga aattgccgat gggagtcgcc gtcgtaaagc 38880
tgctgcactt accgaaagtg attatcgtgt tctggttggc gagctggatg atgagcagat 38940
ggctgcatta tccagattgg gtaacgatta tcgcccaaca agtgcttatg aacgtggtca 39000
gcgttatgca agccgattgc agaatgaatt tgctggaaat atttctgcgc tggctgatgc 39060
ggaaaatatt tcacgtaaga ttattacccg ctgtatcaac accgccaaat tgcctaaatc 39120
agttgttgct cttttttctc accccggtga actatctgcc cggtcaggtg atgcacttca 39180
aaaagccttt acagataaag aggaattact taagcagcag gcatctaacc ttcatgagca 39240
gaaaaaagct ggggtgatat ttgaagctga agaagttatc actcttttaa cttctgtgct 39300
taaaacgtca tctgcatcaa gaactagttt aagctcacga catcagtttg ctcctggagc 39360
gacagtattg tataagggcg ataaaatggt gcttaacctg gacaggtctc gtgttccaac 39420
tgagtgtata gagaaaattg aggccattct taaggaactt gaaaagccag caccctgatg 39480
cgaccacgtt ttagtctacg tttatctgtc tttacttaat gtcctttgtt acaggccaga 39540
aagcataact ggcctgaata ttctctctgg gcccactgtt ccacttgtat cgtcggtctg 39600
ataatcagac tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc 39660
acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc 39720
gtcggtctga taatcagact gggaccacgg tcccactcgt atcgtcggtc tgattattag 39780
tctgggacca tggtcccact cgtatcgtcg gtctgattat tagtctggga ccacggtccc 39840
actcgtatcg tcggtctgat tattagtctg gaaccacggt cccactcgta tcgtcggtct 39900
gattattagt ctgggaccac ggtcccactc gtatcgtcgg tctgattatt agtctgggac 39960
cacgatccca ctcgtgttgt cggtctgatt atcggtctgg gaccacggtc ccacttgtat 40020
tgtcgatcag actatcagcg tgagactacg attccatcaa tgcctgtcaa gggcaagtat 40080
tgacatgtcg tcgtaacctg tagaacggag taacctcggt gtgcggttgt atgcctgctg 40140
tggattgctg ctgtgtcctg cttatccaca acattttgcg cacggttatg tggacaaaat 40200
acctggttac ccaggccgtg ccggcacgtt aaccgggctg catccgatgc aagtgtgtcg 40260
ctgtcgagtt ttcgggggag tccagggttt tcccagtcac gacgttgtaa aacgacggcc 40320
agtgaattcg agctcggtac ccggggatct tgaagttcct attctctaga aagtatagga 40380
acttcaattc ccatgtcagc cgttaagtgt tcctgtgtca ctcaaaattg ctttgagagg 40440
ctctaagggc ttctcagtgc gttacatccc tggcttgttg tccacaaccg ttaaacctta 40500
aaagctttaa aagccttata tattcttttt tttcttataa aacttaaaac cttagaggct 40560
atttaagttg ctgatttata ttaattttat tgttcaaaca tgagagctta gtacgtgaaa 40620
catgagagct tagtacgtta gccatgagag cttagtacgt tagccatgag ggtttagttc 40680
gttaaacatg agagcttagt acgttaaaca tgagagctta gtacgtgaaa catgagagct 40740
tagtacgtac tatcaacagg ttgaactgct gatcttcaga tcctctacgc cggacgcatc 40800
gtggccttaa t 40811
<210> 39
<211> 40863
<212> DNA
<213> 人工序列
<220>
<223> pBWH-R-C5-mChe
<400> 39
agagcgcttt tgaagctggg gtgggcgaag aactccagca tgagatcccc agagcgcttt 60
tgaagctgcg tttaaacgcg atatcccggg agctcccgat atcgcgttta aacgcagctt 120
ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca 180
caacatacga gccggaagac tgaaatgtgt gggcgtggct taagggtggg aaagaatata 240
taaggtgggg gtcttatgta gttttgtatc tgttttgcag cagccgccgc cgccatgagc 300
accaactcgt ttgatggaag cattgtgagc tcatatttga caacgcgcat gcccccatgg 360
gccggggtgc gtcagaatgt gatgggctcc agcattgatg gtcgccccgt cctgcccgca 420
aactctacta ccttgaccta cgagaccgtg tctggaacgc cgttggagac tgcagcctcc 480
gccgccgctt cagccgctgc agccaccgcc cgcgggattg tgactgactt tgctttcctg 540
agcccgcttg caagcagtgc agcttcccgt tcatccgccc gcgatgacaa gttgacggct 600
cttttggcac aattggattc tttgacccgg gaacttaatg tcgtttctca gcagctgttg 660
gatctgcgcc agcaggtttc tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac 720
ataaataaaa aaccagactc tgtttggatt tggatcaagc aagtgtcttg ctgtctttat 780
ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg 840
tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc 900
ccgtctctgg ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag 960
atgatccagt cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag 1020
ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg 1080
tgcatacgtg gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca 1140
gccatatccc tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac 1200
ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg 1260
tgacctccaa gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg 1320
gcctgggcga agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg 1380
tcataggcca tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca 1440
tccggcccag gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat 1500
ggggggatca tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc 1560
agctgggaag aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa 1620
atcacaccta ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg 1680
agcagggggg ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc 1740
gccagaaggc gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac 1800
ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg 1860
tcccacagct cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg 1920
ggttggggcg gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca 1980
tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg 2040
ctccgggctg cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct 2100
gccggtcttc gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc 2160
cctccgcggc gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc 2220
agtgcagact tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg 2280
catccgcgcc gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc 2340
gttcggggtc aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt 2400
ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact 2460
tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact 2520
ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt 2580
cgttgtccac tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg 2640
catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg 2700
ggctataaaa gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga 2760
gggccagctg ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat 2820
tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga 2880
gggtggccgc atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa 2940
acgacccgta gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt 3000
cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc 3060
gccattcggg aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt 3120
tgtgcagggt gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc 3180
agcagaggcg gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt 3240
ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta 3300
tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt 3360
atgggttgag tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc 3420
aaatgtcgta aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc 3480
caccgcggat gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg 3540
gaccgaggtt gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat 3600
gtgagttgga tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta 3660
ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga 3720
cctgcacgtc tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc 3780
cctttttttt ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt 3840
ggatcggaaa cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg 3900
cctggtaggc gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga 3960
gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga 4020
agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac 4080
gcggatttgg cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa 4140
agttgcgtgt gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg 4200
cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc 4260
gcgggatgcc cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg 4320
agctgagccc gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg 4380
agctccacag gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc 4440
gacctatggc cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc 4500
ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc 4560
cgaacttcat gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat 4620
aggtctctac atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga 4680
agaactggat ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt 4740
ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc 4800
ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga 4860
gtgggaattt gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt 4920
gtccttgacc gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg 4980
agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat 5040
gggagctgtc catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt 5100
ttacctcgca tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg 5160
gctggttggt ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg 5220
taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg 5280
acgcgggcga gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg 5340
cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc 5400
gacgacgcgg cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt 5460
gagcttgagc ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg 5520
gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg 5580
ctcgatctct tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc 5640
gttggaaatg cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg 5700
gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag 5760
ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt 5820
ggtggcggtg tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt 5880
gatatccccc aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa 5940
aaactgggag ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc 6000
gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc 6060
ctcttccata agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg 6120
gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg 6180
acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc 6240
gcccgtcatg tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct 6300
aacgatgcat ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc 6360
cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 6420
taggctgagc accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt 6480
gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac 6540
catgtccttg ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt 6600
ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc 6660
ttctccttcc tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg 6720
ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag 6780
cagggctagg tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt 6840
agactggaag tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt 6900
gcagttggcc ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta 6960
cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta 7020
ctggtatccc accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc 7080
cggggctccg ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga 7140
catccaggtg atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca 7200
gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc 7260
gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 7320
gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 7380
cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 7440
cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 7500
ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 7560
tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 7620
tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 7680
cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 7740
tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 7800
gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 7860
cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 7920
ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggt acccaagggt 7980
gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 8040
cgagggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 8100
gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 8160
cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 8220
gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 8280
ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 8340
gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 8400
ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 8460
gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 8520
tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 8580
gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 8640
gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 8700
catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 8760
cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 8820
tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 8880
cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 8940
tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 9000
cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 9060
ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 9120
cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 9180
gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 9240
ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 9300
cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 9360
gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 9420
atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 9480
gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 9540
gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 9600
aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 9660
gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 9720
gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 9780
ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 9840
agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 9900
ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 9960
cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 10020
cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 10080
cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 10140
tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 10200
ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 10260
ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 10320
ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 10380
cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 10440
acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 10500
cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 10560
atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 10620
acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 10680
gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 10740
aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 10800
gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 10860
atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 10920
cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 10980
ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 11040
cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 11100
accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 11160
gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 11220
tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 11280
tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 11340
agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 11400
cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 11460
gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 11520
tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 11580
gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 11640
tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 11700
tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 11760
caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 11820
caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgacacc tttgccacac 11880
gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 11940
aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 12000
agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 12060
accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 12120
ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 12180
accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 12240
tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 12300
gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 12360
gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 12420
ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 12480
gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 12540
cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 12600
ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 12660
cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 12720
ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 12780
ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 12840
ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 12900
ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 12960
gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 13020
ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 13080
gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 13140
cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 13200
atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 13260
tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 13320
cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 13380
aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 13440
taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 13500
gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 13560
acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 13620
tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 13680
cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 13740
ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 13800
tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 13860
tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 13920
ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 13980
tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 14040
tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag gaagtacggc gccgccagcg 14100
cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 14160
acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 14220
gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 14280
aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 14340
cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 14400
gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 14460
tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 14520
tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 14580
tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 14640
aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 14700
aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 14760
atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 14820
aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 14880
cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 14940
gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 15000
agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 15060
ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 15120
atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 15180
atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 15240
ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 15300
cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 15360
gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 15420
aagcgccgac gatgcttctg aatagctaac gtgtcgtatg tgtgtcatgt atgcgtccat 15480
gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct ttccaagatg gctacccctt 15540
cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg gagtacctga 15600
gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg aataacaagt 15660
ttagaaaccc cacggtggcg cctacgcacg acgtgaccac agaccggtcc cagcgtttga 15720
cgctgcggtt catccctgtg gaccgtgagg atactgcgta ctcgtacaag gcgcggttca 15780
ccctagctgt gggtgataac cgtgtgctgg acatggcttc cacgtacttt gacatccgcg 15840
gcgtgctgga caggggccct acttttaagc cctactctgg cactgcctac aacgccctgg 15900
ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc tgctactgct cttgaaataa 15960
acctagaaga agaggacgat gacaacgaag acgaagtaga cgagcaagct gagcagcaaa 16020
aaactcacgt atttgggcag gcgccttatt ctggtataaa tattacaaag gagggtattc 16080
aaataggtgt cgaaggtcaa acacctaaat atgccgataa aacatttcaa cctgaacctc 16140
aaataggaga atctcagtgg tacgaaactg aaattaatca tgcagctggg agagtcctta 16200
aaaagactac cccaatgaaa ccatgttacg gttcatatgc aaaacccaca aatgaaaatg 16260
gagggcaagg cattcttgta aagcaacaaa atggaaagct agaaagtcaa gtggaaatgc 16320
aatttttctc aactactgag gcgaccgcag gcaatggtga taacttgact cctaaagtgg 16380
tattgtacag tgaagatgta gatatagaaa ccccagacac tcatatttct tacatgccca 16440
ctattaagga aggtaactca cgagaactaa tgggccaaca atctatgccc aacaggccta 16500
attacattgc ttttagggac aattttattg gtctaatgta ttacaacagc acgggtaata 16560
tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt tgtagatttg caagacagaa 16620
acacagagct ttcataccag cttttgcttg attccattgg tgatagaacc aggtactttt 16680
ctatgtggaa tcaggctgtt gacagctatg atccagatgt tagaattatt gaaaatcatg 16740
gaactgaaga tgaacttcca aattactgct ttccactggg aggtgtgatt aatacagaga 16800
ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg atgggaaaaa gatgctacag 16860
aattttcaga taaaaatgaa ataagagttg gaaataattt tgccatggaa atcaatctaa 16920
atgccaacct gtggagaaat ttcctgtact ccaacatagc gctgtatttg cccgacaagc 16980
taaagtacag tccttccaac gtaaaaattt ctgataaccc aaacacctac gactacatga 17040
acaagcgagt ggtggctccc gggttagtgg actgctacat taaccttgga gcacgctggt 17100
cccttgacta tatggacaac gtcaacccat ttaaccacca ccgcaatgct ggcctgcgct 17160
accgctcaat gttgctgggc aatggtcgct atgtgccctt ccacatccag gtgcctcaga 17220
agttctttgc cattaaaaac ctccttctcc tgccgggctc atacacctac gagtggaact 17280
tcaggaagga tgttaacatg gttctgcaga gctccctagg aaatgaccta agggttgacg 17340
gagccagcat taagtttgat agcatttgcc tttacgccac cttcttcccc atggcccaca 17400
acaccgcctc cacgcttgag gccatgctta gaaacgacac caacgaccag tcctttaacg 17460
actatctctc cgccgccaac atgctctacc ctatacccgc caacgctacc aacgtgccca 17520
tatccatccc ctcccgcaac tgggcggctt tccgcggctg ggccttcacg cgccttaaga 17580
ctaaggaaac cccatcactg ggctcgggct acgaccctta ttacacctac tctggctcta 17640
taccctacct agatggaacc ttttacctca accacacctt taagaaggtg gccattacct 17700
ttgactcttc tgtcagctgg cctggcaatg accgcctgct tacccccaac gagtttgaaa 17760
ttaagcgctc agttgacggg gagggttaca acgttgccca gtgtaacatg accaaagact 17820
ggttcctggt acaaatgcta gctaactaca acattggcta ccagggcttc tatatcccag 17880
agagctacaa ggaccgcatg tactccttct ttagaaactt ccagcccatg agccgtcagg 17940
tggtggatga tactaaatac aaggactacc aacaggtggg catcctacac caacacaaca 18000
actctggatt tgttggctac cttgccccca ccatgcgcga aggacaggcc taccctgcta 18060
acttccccta tccgcttata ggcaagaccg cagttgacag cattacccag aaaaagtttc 18120
tttgcgatcg caccctttgg cgcatcccat tctccagtaa ctttatgtcc atgggcgcac 18180
tcacagacct gggccaaaac cttctctacg ccaactccgc ccacgcgcta gacatgactt 18240
ttgaggtgga tcccatggac gagcccaccc ttctttatgt tttgtttgaa gtctttgacg 18300
tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct 18360
tctcggccgg caacgccaca acataaagaa gcaagcaaca tcaacaacag ctgccgccat 18420
gggctccagt gagcaggaac tgaaagccat tgtcaaagat cttggttgtg ggccatattt 18480
tttgggcacc tatgacaagc gctttccagg ctttgtttct ccacacaagc tcgcctgcgc 18540
catagtcaat acggccggtc gcgagactgg gggcgtacac tggatggcct ttgcctggaa 18600
cccgcactca aaaacatgct acctctttga gccctttggc ttttctgacc agcgactcaa 18660
gcaggtttac cagtttgagt acgagtcact cctgcgccgt agcgccattg cttcttcccc 18720
cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta caggggccca actcggccgc 18780
ctgtggacta ttctgctgca tgtttctcca cgcctttgcc aactggcccc aaactcccat 18840
ggatcacaac cccaccatga accttattac cggggtaccc aactccatgc tcaacagtcc 18900
ccaggtacag cccaccctgc gtcgcaacca ggaacagctc tacagcttcc tggagcgcca 18960
ctcgccctac ttccgcagcc acagtgcgca gattaggagc gccacttctt tttgtcactt 19020
gaaaaacatg taaaaataat gtactagaga cactttcaat aaaggcaaat gcttttattt 19080
gtacactctc gggtgattat ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa 19140
ggggttctgc cgcgcatcgc tatgcgccac tggcagggac acgttgcgat actggtgttt 19200
agtgctccac ttaaactcag gcacaaccat ccgcggcagc tcggtgaagt tttcactcca 19260
caggctgcgc accatcacca acgcgtttag caggtcgggc gccgatatct tgaagtcgca 19320
gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca gggttgcagc actggaacac 19380
tatcagcgcc gggtggtgca cgctggccag cacgctcttg tcggagatca gatccgcgtc 19440
caggtcctcc gcgttgctca gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa 19500
gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg 19560
cccggtctgg gcgttaggat acagcgcctg cataaaagcc ttgatctgct taaaagccac 19620
ctgagccttt gcgccttcag agaagaacat gccgcaagac ttgccggaaa actgattggc 19680
cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg ttggagatct gcaccacatt 19740
tcggccccac cggttcttca cgatcttggc cttgctagac tgctccttca gcgcgcgctg 19800
cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc ttatttatca taatgcttcc 19860
gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc 19920
cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa 19980
tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag gtcagctgca acccgcggtg 20040
ctcctcgttc agccaggtct tgcatacggc cgccagagct tccacttggt caggcagtag 20100
tttgaagttc gcctttagat cgttatccac gtggtacttg tccatcagcg cgcgcgcagc 20160
ctccatgccc ttctcccacg cagacacgat cggcacactc agcgggttca tcaccgtaat 20220
ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc gtccgcatac cacgcgccac 20280
tgggtcgtct tcattcagcc gccgcactgt gcgcttacct cctttgccat gcttgattag 20340
caccggtggg ttgctgaaac ccaccatttg tagcgccaca tcttctcttt cttcctcgct 20400
gtccacgatt acctctggtg atggcgggcg ctcgggcttg ggagaagggc gcttcttttt 20460
cttcttgggc gcaatggcca aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg 20520
cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg gactcgatac gccgcctcat 20580
ccgctttttt gggggcgccc ggggaggcgg cggcgacggg gacggggacg acacgtcctc 20640
catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc 20700
ctcttcccga ctggccattt ccttctccta taggcagaaa aagatcatgg agtcagtcga 20760
gaagaaggac agcctaaccg ccccctctga gttcgccacc accgcctcca ccgatgccgc 20820
caacgcgcct accaccttcc ccgtcgaggc acccccgctt gaggaggagg aagtgattat 20880
cgagcaggac ccaggttttg taagcgaaga cgacgaggac cgctcagtac caacagagga 20940
taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa caagtcgggc ggggggacga 21000
aaggcatggc gactacctag atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca 21060
gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga 21120
tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc gtacccccca aacgccaaga 21180
aaacggcaca tgcgagccca acccgcgcct caacttctac cccgtatttg ccgtgccaga 21240
ggtgcttgcc acctatcaca tctttttcca aaactgcaag atacccctat cctgccgtgc 21300
caaccgcagc cgagcggaca agcagctggc cttgcggcag ggcgctgtca tacctgatat 21360
cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc 21420
ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt cactctggag tgttggtgga 21480
actcgagggt gacaacgcgc gcctagccgt actaaaacgc agcatcgagg tcacccactt 21540
tgcctacccg gcacttaacc taccccccaa ggtcatgagc acagtcatga gtgagctgat 21600
cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg caagaacaaa cagaggaggg 21660
cctacccgca gttggcgacg agcagctagc gcgctggctt caaacgcgcg agcctgccga 21720
cttggaggag cgacgcaaac taatgatggc cgcagtgctc gttaccgtgg agcttgagtg 21780
catgcagcgg ttctttgctg acccggagat gcagcgcaag ctagaggaaa cattgcacta 21840
cacctttcga cagggctacg tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa 21900
cctggtctcc taccttggaa ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc 21960
cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac tgcgtttact tatttctatg 22020
ctacacctgg cagacggcca tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa 22080
ggagctgcag aaactgctaa agcaaaactt gaaggaccta tggacggcct tcaacgagcg 22140
ctccgtggcc gcgcacctgg cggacatcat tttccccgaa cgcctgctta aaaccctgca 22200
acagggtctg ccagacttca ccagtcaaag catgttgcag aactttagga actttatcct 22260
agagcgctca ggaatcttgc ccgccacctg ctgtgcactt cctagcgact ttgtgcccat 22320
taagtaccgc gaatgccctc cgccgctttg gggccactgc taccttctgc agctagccaa 22380
ctaccttgcc taccactctg acataatgga agacgtgagc ggtgacggtc tactggagtg 22440
tcactgtcgc tgcaacctat gcaccccgca ccgctccctg gtttgcaatt cgcagctgct 22500
taacgaaagt caaattatcg gtacctttga gctgcagggt ccctcgcctg acgaaaagtc 22560
cgcggctccg gggttgaaac tcactccggg gctgtggacg tcggcttacc ttcgcaaatt 22620
tgtacctgag gactaccacg cccacgagat taggttctac gaagaccaat cccgcccgcc 22680
aaatgcggag cttaccgcct gcgtcattac ccagggccac attcttggcc aattgcaagc 22740
catcaacaaa gcccgccaag agtttctgct acgaaaggga cggggggttt acttggaccc 22800
ccagtccggc gaggagctca acccaatccc cccgccgccg cagccctatc agcagcagcc 22860
gcgggccctt gcttcccagg atggcaccca aaaagaagct gcagctgccg ccgccaccca 22920
cggacgagga ggaatactgg gacagtcagg cagaggaggt tttggacgag gaggaggagg 22980
acatgatgga agactgggag agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag 23040
acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg 23100
gttccagcat ggctacaacc tccgctcctc aggcgccgcc ggcactgccc gttcgccgac 23160
ccaaccgtag atgggacacc actggaacca gggccggtaa gtccaagcag ccgccgccgt 23220
tagcccaaga gcaacaacag cgccaaggct accgctcatg gcgcgggcac aagaacgcca 23280
tagttgcttg cttgcaagac tgtgggggca acatctcctt cgcccgccgc tttcttctct 23340
accatcacgg cgtggccttc ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc 23400
catactgcac cggcggcagc ggcagcggca gcaacagcag cggccacaca gaagcaaagg 23460
cgaccggata gcaagactct gacaaagccc aagaaatcca cagcggcggc agcagcagga 23520
ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga cccgcgagct tagaaacagg 23580
atttttccca ctctgtatgc tatatttcaa cagagcaggg gccaagaaca agagctgaaa 23640
ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc tgtatcacaa aagcgaagat 23700
cagcttcggc gcacgctgga agacgcggag gctctcttca gtaaatactg cgcgctgact 23760
cttaaggact agtttcgcgc cctttctcaa atttaagcgc gaaaactacg tcatctccag 23820
cggccacacc cggcgccagc acctgtcgtc agcgccatta tgagcaagga aattcccacg 23880
ccctacatgt ggagttacca gccacaaatg ggacttgcgg ctggagctgc ccaagactac 23940
tcaacccgaa taaactacat gagcgcggga ccccacatga tatcccgggt caacggaatc 24000
cgcgcccacc gaaaccgaat tctcttggaa caggcggcta ttaccaccac acctcgtaat 24060
aaccttaatc cccgtagttg gcccgctgcc ctggtgtacc aggaaagtcc cgctcccacc 24120
actgtggtac ttcccagaga cgcccaggcc gaagttcaga tgactaactc aggggcgcag 24180
cttgcgggcg gctttcgtca cagggtgcgg tcgcccgggc agggtataac tcacctgaca 24240
atcagagggc gaggtattca gctcaacgac gagtcggtga gctcctcgct tggtctccgt 24300
ccggacggga catttcagat cggcggcgcc ggccgtcctt cattcacgcc tcgtcaggca 24360
atcctaactc tgcagacctc gtcctctgag ccgcgctctg gaggcattgg aactctgcaa 24420
tttattgagg agtttgtgcc atcggtctac tttaacccct tctcgggacc tcccggccac 24480
tatccggatc aatttattcc taactttgac gcggtaaagg actcggcgga cggctacgac 24540
tgaatgttaa gtggagaggc agagcaactg cgcctgaaac acctggtcca ctgtcgccgc 24600
cacaagtgct ttgcccgcga ctccggtgag ttttgctact ttgaattgcc cgaggatcat 24660
atcgagggcc cggcgcacgg cgtccggctt accgcccagg gagagcttgc ccgtagcctg 24720
attcgggagt ttacccagcg ccccctgcta gttgagcggg acaggggacc ctgtgttctc 24780
actgtgattt gcaactgtcc taaccttgga ttacatcaag atctttgttg ccatctctgt 24840
gctgagtata ataaatacag aaattaaaat atactggggc tcctatcgcc atcctgtaaa 24900
cgccaccgtc ttcacccgcc caagcaaacc aaggcgaacc ttacctggta cttttaacat 24960
ctctccctct gtgatttaca acagtttcaa cccagacgga gtgagtctac gagagaacct 25020
ctccgagctc agctactcca tcagaaaaaa caccaccctc cttacctgcc gggaacgtac 25080
gagtgcgtca ccggccgctg caccacacct accgcctgac cgtaaaccag actttttccg 25140
gacagacctc aataactctg tttaccagaa caggaggtga gcttagaaaa cccttagggt 25200
attaggccaa aggcgcagct actgtggggt ttatgaacaa ttcaagcaac tctacgggct 25260
attctaattc aggtttctct agaaatggac ggaattatta cagagcagcg cctgctagaa 25320
agacgcaggg cagcggccga gcaacagcgc atgaatcaag agctccaaga catggttaac 25380
ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc aggccaaagt cacctacgac 25440
agtaatacca ccggacaccg ccttagctac aagttgccaa ccaagcgtca gaaattggtg 25500
gtcatggtgg gagaaaagcc cattaccata actcagcact cggtagaaac cgaaggctgc 25560
attcactcac cttgtcaagg acctgaggat ctctgcaccc ttattaagac cctgtgcggt 25620
ctcaaagatc ttattccctt taactaataa aaaaaaataa taaagcatca cttacttaaa 25680
atcagttagc aaatttctgt ccagtttatt cagcagcacc tccttgccct cctcccagct 25740
ctggtattgc agcttcctcc tggctgcaaa ctttctccac aatctaaatg gaatgtcagt 25800
ttcctcctgt tcctgtccat ccgcacccac tatcttcatg ttgttgcaga tgaagcgcgc 25860
aagaccgtct gaagatacct tcaaccccgt gtatccatat gacacggaaa ccggtcctcc 25920
aactgtgcct tttcttactc ctccctttgt atcccccaat gggtttcaag agagtccccc 25980
tggggtactc tctttgcgcc tatccgaacc tctagttacc tccaatggca tgcttgcgct 26040
caaaatgggc aacggcctct ctctggacga ggccggcaac cttacctccc aaaatgtaac 26100
cactgtgagc ccacctctca aaaaaaccaa gtcaaacata aacctggaaa tatctgcacc 26160
cctcacagtt acctcagaag ccctaactgt ggctgccgcc gcacctctaa tggtcgcggg 26220
caacacactc accatgcaat cacaggcccc gctaaccgtg cacgactcca aacttagcat 26280
tgccacccaa ggacccctca cagtgtcaga aggaaagcta gccctgcaaa catcaggccc 26340
cctcaccacc accgatagca gtacccttac tatcactgcc tcaccccctc taactactgc 26400
cactggtagc ttgggcattg acttgaaaga gcccatttat acacaaaatg gaaaactagg 26460
actaaagtac ggggctcctt tgcatgtaac agacgaccta aacactttga ccgtagcaac 26520
tggtccaggt gtgactatta ataatacttc cttgcaaact aaagttactg gagccttggg 26580
ttttgattca caaggcaata tgcaacttaa tgtagcagga ggactaagga ttgattctca 26640
aaacagacgc cttatacttg atgttagtta tccgtttgat gctcaaaacc aactaaatct 26700
aagactagga cagggccctc tttttataaa ctcagcccac aacttggata ttaactacaa 26760
caaaggcctt tacttgttta cagcttcaaa caattccaaa aagcttgagg ttaacctaag 26820
cactgccaag gggttgatgt ttgacgctac agccatagcc attaatgcag gagatgggct 26880
tgaatttggt tcacctaatg caccaaacac aaatcccctc aaaacaaaaa ttggccatgg 26940
cctagaattt gattcaaaca aggctatggt tcctaaacta ggaactggcc ttagttttga 27000
cagcacaggt gccattacag taggaaacaa aaataatgat aagctaactt tgtggaccac 27060
accagctcca tctcctaact gtagactaaa tgcagagaaa gatgctaaac tcactttggt 27120
cttaacaaaa tgtggcagtc aaatacttgc tacagtttca gttttggctg ttaaaggcag 27180
tttggctcca atatctggaa cagttcaaag tgctcatctt attataagat ttgacgaaaa 27240
tggagtgcta ctaaacaatt ccttcctgga cccagaatat tggaacttta gaaatggaga 27300
tcttactgaa ggcacagcct atacaaacgc tgttggattt atgcctaacc tatcagctta 27360
tccaaaatct cacggtaaaa ctgccaaaag taacattgtc agtcaagttt acttaaacgg 27420
agacaaaact aaacctgtaa cactaaccat tacactaaac ggtacacagg aaacaggaga 27480
cacaactcca agtgcatact ctatgtcatt ttcatgggac tggtctggcc acaactacat 27540
taatgaaata tttgccacat cctcttacac tttttcatac attgcccaag aataaagaat 27600
cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttcg aatcattttt 27660
cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa 27720
ctcacagaac cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc 27780
tttctccccg gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg 27840
ttatattcca cacggtttcc tgtcgagcca aacgctcatc agtgatatta ataaactccc 27900
cgggcagctc acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa 27960
cttgcggttg cttaacgggc ggcgaaggag aagtccacgc ctacatgggg gtagagtcat 28020
aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc 28080
gccgctccgt cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg 28140
cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc tcacttaaat 28200
cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc 28260
tgtatccaaa gctcatggcg gggaccacag aacccacgtg gccatcatac cacaagcgca 28320
ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca 28380
tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca 28440
ccaccatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc agggaaccgg 28500
gactggaaca atgacagtgg agagcccagg actcgtaacc atggatcatc atgctcgtca 28560
tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg attacaagct 28620
cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc gtaaatccca 28680
cactgcaggg aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg ttacattcgg 28740
gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 28800
gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 28860
caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 28920
acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc 28980
cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 29040
gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 29100
tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gttttttttt 29160
ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 29220
tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 29280
cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 29340
ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 29400
atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt 29460
aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 29520
aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac aaaaataccg 29580
cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc 29640
agcgcggcca cttccccgcc aggaaccttg acaaaagaac ccacactgat tatgacacgc 29700
atactcggag ctatgctaac cagcgtagcc ccgatgtaag ctttgttgca tgggcggcga 29760
tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac 29820
atcgtagtca tgctcatgca gataaaggca ggtaagctcc ggaaccacca cagaaaaaga 29880
caccattttt ctctcaaaca tgtctgcggg tttctgcata aacacaaaat aaaataacaa 29940
aaaaacattt aaacattaga agcctgtctt acaacaggaa aaacaaccct tataagcata 30000
agacggacta cggccatgcc ggcgtgaccg taaaaaaact ggtcaccgtg attaaaaagc 30060
accaccgaca gctcctcggt catgtccgga gtcataatgt aagactcggt aaacacatca 30120
ggttgattca catcggtcag tgctaaaaag cgaccgaaat agcccggggg aatacatacc 30180
cgcaggcgta gagacaacat tacagccccc ataggaggta taacaaaatt aataggagag 30240
aaaaacacat aaacacctga aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc 30300
agaacaacat acagcgcttc cacagcggca gccataacag tcagccttac cagtaaaaaa 30360
gaaaacctat taaaaaaaca ccactcgaca cggcaccagc tcaatcagtc acagtgtaaa 30420
aaagggccaa gtgcagagcg agtatatata ggactaaaaa atgacgtaac ggttaaagtc 30480
cacaaaaaac acccagaaaa ccgcacgcga acctacgccc agaaacgaaa gccaaaaaac 30540
ccacaacttc ctcaaatcgt cacttccgtt ttcccacgtt acgtcacttc ccattttaag 30600
aaaactacaa ttcccaacac atacaagtta ctccgcccta aaacctacgt cacccgcccc 30660
gttcccacgc cccgcgccac gtcacaaact ccaccccctc attatcatat tggcttcaat 30720
ccaaaataag gtatattatt gatgatgcct ccggggtcca ctgcaattaa taacttcgta 30780
tagcatacat tatacgaagt tatttaatta agggcggccg cacgggccat cgatggggat 30840
cctaacttta aataatgcca attatttaaa gttaatccgc ggagaagctt ctcgaccaat 30900
tctcatgttt gacagcttat catcgaattt ctgccattca tccgcttatt atcacttatt 30960
caggcgtagc aaccaggcgt ttaagggcac caataactgc cttaaaaaaa ttacgccccg 31020
ccctgccact catcgcagta ctgttgtaat tcattaagca ttctgccgac atggaagcca 31080
tcacagacgg catgatgaac ctgaatcgcc agcggcatca gcaccttgtc gccttgcgta 31140
taatatttgc ccatggtgaa aacgggggcg aagaagttgt ccatattggc cacgtttaaa 31200
tcaaaactgg tgaaactcac ccagggattg gctgagacga aaaacatatt ctcaataaac 31260
cctttaggga aataggccag gttttcaccg taacacgcca catcttgcga atatatgtgt 31320
agaaactgcc ggaaatcgtc gtggtattca ctccagagcg atgaaaacgt ttcagtttgc 31380
tcatggaaaa cggtgtaaca agggtgaaca ctatcccata tcaccagctc accgtctttc 31440
attgccatac ggaattccgg atgagcattc atcaggcggg caagaatgtg aataaaggcc 31500
ggataaaact tgtgcttatt tttctttacg gtctttaaaa aggccgtaat atccagctga 31560
acggtctggt tataggtaca ttgagcaact gactgaaatg cctcaaaatg ttctttacga 31620
tgccattggg atatatcaac ggtggtatat ccagtgattt ttttctccat tttagcttcc 31680
ttagctcctg aaaatctcga taactcaaaa aatacgcccg gtagtgatct tatttcatta 31740
tggtgaaagt tggaacctct tacgtgccga tcaacgtctc attttcgcca aaagttggcc 31800
cagggcttcc cggtatcaac agggacacca ggatttattt attctgcgaa gtgatcttcc 31860
gtcacaggta tttattcgcg ataagctcat ggagcggcgt aaccgtcgca caggaaggac 31920
agagaaagcg cggatctggg aagtgacgga cagaacggtc aggacctgga ttggggaggc 31980
ggttgccgcc gctgctgctg acggtgtgac gttctctgtt ccggtcacac cacatacgtt 32040
ccgccattcc tatgcgatgc acatgctgta tgccggtata ccgctgaaag ttctgcaaag 32100
cctgatggga cataagtcca tcagttcaac ggaagtctac acgaaggttt ttgcgctgga 32160
tgtggctgcc cggcaccggg tgcagtttgc gatgccggag tctgatgcgg ttgcgatgct 32220
gaaacaatta tcctgagaat aaatgccttg gcctttatat ggaaatgtgg aactgagtgg 32280
atatgctgtt tttgtctgtt aaacagagaa gctggctgtt atccactgag aagcgaacga 32340
aacagtcggg aaaatctccc attatcgtag agatccgcat tattaatctc aggagcctgt 32400
gtagcgttta taggaagtag tgttctgtca tgatgcctgc aagcggtaac gaaaacgatt 32460
tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg ttacgttgaa gtggagcgga 32520
ttatgtcagc aatggacaga acaacctaat gaacacagaa ccatgatgtg gtctgtcctt 32580
ttacagccag taggctcgcc gcagtcgagc gacggcgaag ccctcgagtg agcgaggaag 32640
caccagggaa cagcacttat atattctgct tacacacgat gcctgaaaaa acttcccttg 32700
gggttatcca cttatccacg gggatatttt tataattatt ttttttatag tttttagatc 32760
ttctttttta gagcgccttg taggccttta tccatgctgg ttctagagaa ggtgttgtga 32820
caaattgccc tttcagtgtg acaaatcacc ctcaaatgac agtcctgtct gtgacaaatt 32880
gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt tttttcacaa agttatccct 32940
gcttattgac tcttttttat ttagtgtgac aatctaaaaa cttgtcacac ttcacatgga 33000
tctgtcatgg cggaaacagc ggttatcaat cacaagaaac gtaaaaatag cccgcgaatc 33060
gtccagtcaa acgacctcac tgaggcggca tatagtctct cccgggatca aaaacgtatg 33120
ctgtatctgt tcgttgacca gatcagaaaa tctgatggca ccctacagga acatgacggt 33180
atctgcgaga tccatgttgc taaatatgct gaaatattcg gattgacctc tgcggaagcc 33240
agtaaggata tacggcaggc attgaagagt ttcgcgggga aggaagtggt tttttatcgc 33300
cctgaagagg atgccggcga tgaaaaaggc tatgaatctt ttccttggtt tatcaaacgt 33360
gcgcacagtc catccagagg gctttacagt gtacatatca acccatatct cattcccttc 33420
tttatcgggt tacagaaccg gtttacgcag tttcggctta gtgaaacaaa agaaatcacc 33480
aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt atcgtaagcc ggatggctca 33540
ggcatcgtct ctctgaaaat cgactggatc atagagcgtt accagctgcc tcaaagttac 33600
cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct gtgttaatga gatcaacagc 33660
agaactccaa tgcgcctctc atacattgag aaaaagaaag gccgccagac gactcatatc 33720
gtattttcct tccgcgatat cacttccatg acgacaggat agtctgaggg ttatctgtca 33780
cagatttgag ggtggttcgt cacatttgtt ctgacctact gagggtaatt tgtcacagtt 33840
ttgctgtttc cttcagcctg catggatttt ctcatacttt ttgaactgta atttttaagg 33900
aagccaaatt tgagggcagt ttgtcacagt tgatttcctt ctctttccct tcgtcatgtg 33960
acctgatatc gggggttagt tcgtcatcat tgatgagggt tgattatcac agtttattac 34020
tctgaattgg ctatccgcgt gtgtacctct acctggagtt tttcccacgg tggatatttc 34080
ttcttgcgct gagcgtaaga gctatctgac agaacagttc ttctttgctt cctcgccagt 34140
tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta gtgataataa gtgactgagg 34200
tatgtgctct tcttatctcc ttttgtagtg ttgctcttat tttaaacaac tttgcggttt 34260
tttgatgact ttgcgatttt gttgttgctt tgcagtaaat tgcaagattt aataaaaaaa 34320
cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat ggaaacactt aaccagtgca 34380
taaacgctgg tcatgaaatg acgaaggcta tcgccattgc acagtttaat gatgacagcc 34440
cggaagcgag gaaaataacc cggcgctgga gaataggtga agcagcggat ttagttgggg 34500
tttcttctca ggctatcaga gatgccgaga aagcagggcg actaccgcac ccggatatgg 34560
aaattcgagg acgggttgag caacgtgttg gttatacaat tgaacaaatt aatcatatgc 34620
gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt atttccaccg gtgatcgggg 34680
ttgctgccca taaaggtggc gtttacaaaa cctcagtttc tgttcatctt gctcaggatc 34740
tggctctgaa ggggctacgt gttttgctcg tggaaggtaa cgacccccag ggaacagcct 34800
caatgtatca cggatgggta ccagatcttc atattcatgc agaagacact ctcctgcctt 34860
tctatcttgg ggaaaaggac gatgtcactt atgcaataaa gcccacttgc tggccggggc 34920
ttgacattat tccttcctgt ctggctctgc accgtattga aactgagtta atgggcaaat 34980
ttgatgaagg taaactgccc accgatccac acctgatgct ccgactggcc attgaaactg 35040
ttgctcatga ctatgatgtc atagttattg acagcgcgcc taacctgggt atcggcacga 35100
ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac gcctgctgag ttgtttgact 35160
acacctccgc actgcagttt ttcgatatgc ttcgtgatct gctcaagaac gttgatctta 35220
aagggttcga gcctgatgta cgtattttgc ttaccaaata cagcaatagt aatggctctc 35280
agtccccgtg gatggaggag caaattcggg atgcctgggg aagcatggtt ctaaaaaatg 35340
ttgtacgtga aacggatgaa gttggtaaag gtcagatccg gatgagaact gtttttgaac 35400
aggccattga tcaacgctct tcaactggtg cctggagaaa tgctctttct atttgggaac 35460
ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg ctgggagatt agataatgaa 35520
gcgtgcgcct gttattccaa aacatacgct caatactcaa ccggttgaag atacttcgtt 35580
atcgacacca gctgccccga tggtggattc gttaattgcg cgcgtaggag taatggctcg 35640
cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg aagtttactc ttgaagtgct 35700
ccggggtgat agtgttgaga agacctctcg ggtatggtca ggtaatgaac gtgaccagga 35760
gctgcttact gaggacgcac tggatgatct catcccttct tttctactga ctggtcaaca 35820
gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa attgccgatg ggagtcgccg 35880
tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt ctggttggcg agctggatga 35940
tgagcagatg gctgcattat ccagattggg taacgattat cgcccaacaa gtgcttatga 36000
acgtggtcag cgttatgcaa gccgattgca gaatgaattt gctggaaata tttctgcgct 36060
ggctgatgcg gaaaatattt cacgtaagat tattacccgc tgtatcaaca ccgccaaatt 36120
gcctaaatca gttgttgctc ttttttctca ccccggtgaa ctatctgccc ggtcaggtga 36180
tgcacttcaa aaagccttta cagataaaga ggaattactt aagcagcagg catctaacct 36240
tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa gaagttatca ctcttttaac 36300
ttctgtgctt aaaacgtcat ctgcatcaag aactagttta agctcacgac atcagtttgc 36360
tcctggagcg acagtattgt ataagggcga taaaatggtg cttaacctgg acaggtctcg 36420
tgttccaact gagtgtatag agaaaattga ggccattctt aaggaacttg aaaagccagc 36480
accctgatgc gaccacgttt tagtctacgt ttatctgtct ttacttaatg tcctttgtta 36540
caggccagaa agcataactg gcctgaatat tctctctggg cccactgttc cacttgtatc 36600
gtcggtctga taatcagact gggaccacgg tcccactcgt atcgtcggtc tgattattag 36660
tctgggacca cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacggtccc 36720
actcgtatcg tcggtctgat aatcagactg ggaccacggt cccactcgta tcgtcggtct 36780
gattattagt ctgggaccat ggtcccactc gtatcgtcgg tctgattatt agtctgggac 36840
cacggtccca ctcgtatcgt cggtctgatt attagtctgg aaccacggtc ccactcgtat 36900
cgtcggtctg attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta 36960
gtctgggacc acgatcccac tcgtgttgtc ggtctgatta tcggtctggg accacggtcc 37020
cacttgtatt gtcgatcaga ctatcagcgt gagactacga ttccatcaat gcctgtcaag 37080
ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt aacctcggtg tgcggttgta 37140
tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa cattttgcgc acggttatgt 37200
ggacaaaata cctggttacc caggccgtgc cggcacgtta accgggctgc atccgatgca 37260
agtgtgtcgc tgtcgagttt tcgggggagt ccagggtttt cccagtcacg acgttgtaaa 37320
acgacggcca gtgaattcga gctcggtacc cggggatctt gaagttccta ttctctagaa 37380
agtataggaa cttcaattcc catgtcagcc gttaagtgtt cctgtgtcac tcaaaattgc 37440
tttgagaggc tctaagggct tctcagtgcg ttacatccct ggcttgttgt ccacaaccgt 37500
taaaccttaa aagctttaaa agccttatat attctttttt ttcttataaa acttaaaacc 37560
ttagaggcta tttaagttgc tgatttatat taattttatt gttcaaacat gagagcttag 37620
tacgtgaaac atgagagctt agtacgttag ccatgagagc ttagtacgtt agccatgagg 37680
gtttagttcg ttaaacatga gagcttagta cgttaaacat gagagcttag tacgtgaaac 37740
atgagagctt agtacgtact atcaacaggt tgaactgctg atcttcagat cctctacgcc 37800
ggacgcatcg tggccttaat taacatatgg atttattcaa caaagccacg ttgtgtctca 37860
aaatctctga tgttacattg cacaagataa aaatatatca tcatgaacaa taaaactgtc 37920
tgcttacata aacagtaata caaggggtgt tatgagccat attcaacggg aaacgtcttg 37980
ctcgaggccg cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg 38040
cgataatgtc gggcaatcag gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc 38100
agagttgttt ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt 38160
cagactaaac tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac 38220
tcctgatgat gcatggttac tcaccactgc gatccccggg aaaacagcat tccaggtatt 38280
agaagaatat cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg 38340
gttgcattcg attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc 38400
tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg 38460
taatggctgg cctgttgaac aagtctggaa agaaatgcat aagcttttgc cattctcacc 38520
ggattcagtc gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa 38580
attaataggt tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc 38640
catcctatgg aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa 38700
atatggtatt gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt 38760
tttctaatca gaattggtta attggttgta acactgggca tgccatcatc aataatatac 38820
cttattttgg attgaagcca atatgataat gagggggtgg agtttgtgac gtggcgcggg 38880
gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag tgtgatgttg caagtgtggc 38940
ggaacacatg taagcgacgg atgtggcaaa agtgacgttt ttggtgtgcg ccggtgtaca 39000
caggaagtga caattttcgc gcggttttag gcggatgttg tagtaaattt gggcgtaacc 39060
gagtaagatt tggccatttt cgcgggaaaa ctgaataaga ggaagtgaaa tctgaataat 39120
tttgtgttac tcatagcgcg taataatagt aatcaattac ggggtcatta gttcatagcc 39180
catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca 39240
acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga 39300
ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc 39360
aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct 39420
ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat 39480
tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc 39540
ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt 39600
ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa 39660
tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc 39720
agatccgcta gcgctaccgg actcagatct cgagctcaag cttcgaattc tgcagtcgac 39780
ggtaccgagc tcggatcccg ccaccatggt gagcaagggc gaggaggata acatggccat 39840
catcaaggag ttcatgcgct tcaaggtgca catggagggc tccgtgaacg gccacgagtt 39900
cgagatcgag ggcgagggcg agggccgccc ctacgagggc acccagaccg ccaagctgaa 39960
ggtgaccaag ggtggccccc tgcccttcgc ctgggacatc ctgtcccctc agttcatgta 40020
cggctccaag gcctacgtga agcaccccgc cgacatcccc gactacttga agctgtcctt 40080
ccccgagggc ttcaagtggg agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt 40140
gacccaggac tcctccctgc aggacggcga gttcatctac aaggtgaagc tgcgcggcac 40200
caacttcccc tccgacggcc ccgtaatgca gaagaagacc atgggctggg aggcctcctc 40260
cgagcggatg taccccgagg acggcgccct gaagggcgag atcaagcaga ggctgaagct 40320
gaaggacggc ggccactacg acgctgaggt caagaccacc tacaaggcca agaagcccgt 40380
gcagctgccc ggcgcctaca acgtcaacat caagttggac atcacctccc acaacgagga 40440
ctacaccatc gtggaacagt acgaacgcgc cgagggccgc cactccaccg gcggcatgga 40500
cgagctgtac aagtaagaat tctgcagata tccagcacag tggcggccgc gactctagat 40560
cataatcagc cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct 40620
ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc 40680
ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc 40740
actgcattct agttgtggtt tgtccaaact catcaatgta tcttaaatcg aattcaagct 40800
tgtcgactcg aagatctgag ctcacgcgtg aagttcctat tctctagaaa gtataggaac 40860
ttc 40863
<210> 40
<211> 44348
<212> DNA
<213> 人工序列
<220>
<223> pBWH-C5-gRNA-mChe
<400> 40
gtagtgatct tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc 60
attttcgcca aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt 120
attctgcgaa gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt 180
aaccgtcgca caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc 240
aggacctgga ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt 300
ccggtcacac cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata 360
ccgctgaaag ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac 420
acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag 480
tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat 540
ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt 600
atccactgag aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat 660
tattaatctc aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc 720
aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg 780
ttacgttgaa gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa 840
ccatgatgtg gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag 900
ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat 960
gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt tataattatt 1020
ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg 1080
ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac 1140
agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt 1200
tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa 1260
cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac 1320
gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct 1380
cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca 1440
ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg 1500
gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga 1560
aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt 1620
ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca 1680
acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta 1740
gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt 1800
atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt 1860
accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct 1920
gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag 1980
gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat 2040
agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact 2100
gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt 2160
ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt 2220
ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt 2280
tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt 2340
tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc 2400
ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta 2460
gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat 2520
tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat 2580
tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat 2640
ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc 2700
acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga 2760
agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg 2820
actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat 2880
tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt 2940
atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc 3000
tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa 3060
cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc 3120
agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa 3180
gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga 3240
aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct 3300
ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc 3360
taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac 3420
gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct 3480
gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata 3540
cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg 3600
aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg 3660
gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa 3720
tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg 3780
ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa 3840
ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg 3900
cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg 3960
aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca 4020
ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct 4080
tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa 4140
attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt 4200
ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg taacgattat 4260
cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt 4320
gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc 4380
tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa 4440
ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt 4500
aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa 4560
gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta 4620
agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg 4680
cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt 4740
aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct 4800
ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg 4860
cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt 4920
atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 4980
tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt 5040
cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg 5100
tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 5160
aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 5220
tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta 5280
tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga 5340
ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt 5400
aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa 5460
cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta 5520
accgggctgc atccgatgca agtgtgtcgc tgtcgagttt tcgggggagt ccagggtttt 5580
cccagtcacg acgttgtaaa acgacggcca gtgaattcga gctcggtacc cggggatctt 5640
gaagttccta ttctctagaa agtataggaa cttcaattcc catgtcagcc gttaagtgtt 5700
cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 5760
ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 5820
ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 5880
gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 5940
ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 6000
gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 6060
atcttcagat cctctacgcc ggacgcatcg tggccttaat taacatatgg atttattcaa 6120
caaagccacg ttgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca 6180
tcatgaacaa taaaactgtc tgcttacata aacagtaata caaggggtgt tatgagccat 6240
attcaacggg aaacgtcttg ctcgaggccg cgattaaatt ccaacatgga tgctgattta 6300
tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgattg 6360
tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat 6420
gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc 6480
atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccggg 6540
aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg 6600
ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc 6660
gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg 6720
agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat 6780
aagcttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac 6840
cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca 6900
gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta 6960
cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt 7020
catttgatgc tcgatgagtt tttctaatca gaattggtta attggttgta acactgggca 7080
tgctaattgc agtggacccc ggaggcatca tcaataatat accttatttt ggattgaagc 7140
caatatgata atgagggggt ggagtttgtg acgtggcgcg gggcgtggga acggggcggg 7200
tgacgtagta gtgtggcgga agtgtgatgt tgcaagtgtg gcggaacaca tgtaagcgac 7260
ggatgtggca aaagtgacgt ttttggtgtg cgccggtgta cacaggaagt gacaattttc 7320
gcgcggtttt aggcggatgt tgtagtaaat ttgggcgtaa ccgagtaaga tttggccatt 7380
ttcgcgggaa aactgaataa gaggaagtga aatctgaata attttgtgtt actcatagcg 7440
cgtaataata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg 7500
ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga 7560
cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat 7620
gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa 7680
gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca 7740
tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca 7800
tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 7860
ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 7920
actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 7980
ggtgggaggt ctatataagc agagctggtt tagtgaaccg tcagatccgc tagcgctacc 8040
ggactcagat ctcgagctca agcttcgaat tctgcagtcg acggtaccga gctcggatcc 8100
cgccaccatg gtgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg 8160
cttcaaggtg cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg 8220
cgagggccgc ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc 8280
cctgcccttc gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt 8340
gaagcacccc gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg 8400
ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct 8460
gcaggacggc gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg 8520
ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga 8580
ggacggcgcc ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta 8640
cgacgctgag gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta 8700
caacgtcaac atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca 8760
gtacgaacgc gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaaga 8820
attctgcaga tatccagcac agtggcggcc gcgactctag atcataatca gccataccac 8880
atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 8940
taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 9000
aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 9060
tttgtccaaa ctcatcaatg tatcttaaat cgaattcaag cttgtcgact cgaagatctg 9120
agctcacgcg tgaagttcct attccgaagt tcctattctc tagaaagtat aggaacttca 9180
gagcgctttt gaagctgggg tgggcgaaga actccagcat gagatcccca gagcgctttt 9240
gaagctgcgt ttaaacgcga tatcccggga gctcccgata tcgcgtttaa acgcagcttg 9300
gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 9360
aacatacgag ccggaagact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 9420
aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 9480
ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 9540
ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 9600
actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 9660
ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 9720
gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 9780
ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 9840
atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 9900
taaataaaaa accagactct gtttggattt ggatcaagca agtgtcttgc tgtctttatt 9960
taggggtttt gcgcgcgcgg taggcccggg accagcggtc tcggtcgttg agggtcctgt 10020
gtattttttc caggacgtgg taaaggtgac tctggatgtt cagatacatg ggcataagcc 10080
cgtctctggg gtggaggtag caccactgca gagcttcatg ctgcggggtg gtgttgtaga 10140
tgatccagtc gtagcaggag cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc 10200
tgattgccag gggcaggccc ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt 10260
gcatacgtgg ggatatgaga tgcatcttgg actgtatttt taggttggct atgttcccag 10320
ccatatccct ccggggattc atgttgtgca gaaccaccag cacagtgtat ccggtgcact 10380
tgggaaattt gtcatgtagc ttagaaggaa atgcgtggaa gaacttggag acgcccttgt 10440
gacctccaag attttccatg cattcgtcca taatgatggc aatgggccca cgggcggcgg 10500
cctgggcgaa gatatttctg ggatcactaa cgtcatagtt gtgttccagg atgagatcgt 10560
cataggccat ttttacaaag cgcgggcgga gggtgccaga ctgcggtata atggttccat 10620
ccggcccagg ggcgtagtta ccctcacaga tttgcatttc ccacgctttg agttcagatg 10680
gggggatcat gtctacctgc ggggcgatga agaaaacggt ttccggggta ggggagatca 10740
gctgggaaga aagcaggttc ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa 10800
tcacacctat taccgggtgc aactggtagt taagagagct gcagctgccg tcatccctga 10860
gcaggggggc cacttcgtta agcatgtccc tgactcgcat gttttccctg accaaatccg 10920
ccagaaggcg ctcgccgccc agcgatagca gttcttgcaa ggaagcaaag tttttcaacg 10980
gtttgagacc gtccgccgta ggcatgcttt tgagcgtttg accaagcagt tccaggcggt 11040
cccacagctc ggtcacctgc tctacggcat ctcgatccag catatctcct cgtttcgcgg 11100
gttggggcgg ctttcgctgt acggcagtag tcggtgctcg tccagacggg ccagggtcat 11160
gtctttccac gggcgcaggg tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc 11220
tccgggctgc gcgctggcca gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg 11280
ccggtcttcg ccctgcgcgt cggccaggta gcatttgacc atggtgtcat agtccagccc 11340
ctccgcggcg tggcccttgg cgcgcagctt gcccttggag gaggcgccgc acgaggggca 11400
gtgcagactt ttgagggcgt agagcttggg cgcgagaaat accgattccg gggagtaggc 11460
atccgcgccg caggccccgc agacggtctc gcattccacg agccaggtga gctctggccg 11520
ttcggggtca aaaaccaggt ttcccccatg ctttttgatg cgtttcttac ctctggtttc 11580
catgagccgg tgtccacgct cggtgacgaa aaggctgtcc gtgtccccgt atacagactt 11640
gagaggcctg tcctcgagcg gtgttccgcg gtcctcctcg tatagaaact cggaccactc 11700
tgagacaaag gctcgcgtcc aggccagcac gaaggaggct aagtgggagg ggtagcggtc 11760
gttgtccact agggggtcca ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc 11820
atcaaggaag gtgattggtt tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg 11880
gctataaaag ggggtggggg cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag 11940
ggccagctgt tggggtgagt actccctctg aaaagcgggc atgacttctg cgctaagatt 12000
gtcagtttcc aaaaacgagg aggatttgat attcacctgg cccgcggtga tgcctttgag 12060
ggtggccgca tccatctggt cagaaaagac aatctttttg ttgtcaagct tggtggcaaa 12120
cgacccgtag agggcgttgg acagcaactt ggcgatggag cgcagggttt ggtttttgtc 12180
gcgatcggcg cgctccttgg ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg 12240
ccattcggga aagacggtgg tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt 12300
gtgcagggtg acaaggtcaa cgctggtggc tacctctccg cgtaggcgct cgttggtcca 12360
gcagaggcgg ccgcccttgc gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc 12420
cggggggtct gcgtccacgg taaagacccc gggcagcagg cgcgcgtcga agtagtctat 12480
cttgcatcct tgcaagtcta gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta 12540
tgggttgagt gggggacccc atggcatggg gtgggtgagc gcggaggcgt acatgccgca 12600
aatgtcgtaa acgtagaggg gctctctgag tattccaaga tatgtagggt agcatcttcc 12660
accgcggatg ctggcgcgca cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg 12720
accgaggttg ctacgggcgg gctgctctgc tcggaagact atctgcctga agatggcatg 12780
tgagttggat gatatggttg gacgctggaa gacgttgaag ctggcgtctg tgagacctac 12840
cgcgtcacgc acgaaggagg cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac 12900
ctgcacgtct agggcgcagt agtccagggt ttccttgatg atgtcatact tatcctgtcc 12960
cttttttttc cacagctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg 13020
gatcggaaac ccgtcggcct ccgaacggta agagcctagc atgtagaact ggttgacggc 13080
ctggtaggcg cagcatccct tttctacggg tagcgcgtat gcctgcgcgg ccttccggag 13140
cgaggtgtgg gtgagcgcaa aggtgtccct gaccatgact ttgaggtact ggtatttgaa 13200
gtcagtgtcg tcgcatccgc cctgctccca gagcaaaaag tccgtgcgct ttttggaacg 13260
cggatttggc agggcgaagg tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa 13320
gttgcgtgtg atgcggaagg gtcccggcac ctcggaacgg ttgttaatta cctgggcggc 13380
gagcacgatc tcgtcaaagc cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg 13440
cgggatgccc ttgatggaag gcaatttttt aagttcctcg taggtgagct cttcagggga 13500
gctgagcccg tgctctgaaa gggcccagtc tgcaagatga gggttggaag cgacgaatga 13560
gctccacagg tcacgggcca ttagcatttg caggtggtcg cgaaaggtcc taaactggcg 13620
acctatggcc attttttctg gggtgatgca gtagaaggta agcgggtctt gttcccagcg 13680
gtcccatcca aggttcgcgg ctaggtctcg cgcggcagtc actagaggct catctccgcc 13740
gaacttcatg accagcatga agggcacgag ctgcttccca aaggccccca tccaagtata 13800
ggtctctaca tcgtaggtga caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa 13860
gaactggatc tcccgccacc aattggagga gtggctattg atgtggtgaa agtagaagtc 13920
cctgcgacgg gccgaacact cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg 13980
gtgcacgggc tgtacatcct gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag 14040
tgggaatttg agcccctcgc ctggcgggtt tggctggtgg tcttctactt cggctgcttg 14100
tccttgaccg tctggctgct cgaggggagt tacggtggat cggaccacca cgccgcgcga 14160
gcccaaagtc cagatgtccg cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg 14220
ggagctgtcc atggtctgga gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt 14280
tacctcgcat agacgggtca gggcgcgggc tagatccagg tgatacctaa tttccagggg 14340
ctggttggtg gcggcgtcga tggcttgcaa gaggccgcat ccccgcggcg cgactacggt 14400
accgcgcggc gggcggtggg ccgcgggggt gtccttggat gatgcatcta aaagcggtga 14460
cgcgggcgag cccccggagg tagggggggc tccggacccg ccgggagagg gggcaggggc 14520
acgtcggcgc cgcgcgcggg caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg 14580
acgacgcggc ggttgatctc ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg 14640
agcttgagcc tgaaagagag ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg 14700
cgcaaaatct cctgcacgtc tcctgagttg tcttgatagg cgatctcggc catgaactgc 14760
tcgatctctt cctcctggag atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg 14820
ttggaaatgc gggccatgag ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg 14880
ctgtagacca cgcccccttc ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc 14940
tccacgtgcc gggcgaagac ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg 15000
gtggcggtgt gttctgccac gaagaagtac ataacccagc gtcgcaacgt ggattcgttg 15060
atatccccca aggcctcaag gcgctccatg gcctcgtaga agtccacggc gaagttgaaa 15120
aactgggagt tgcgcgccga cacggttaac tcctcctcca gaagacggat gagctcggcg 15180
acagtgtcgc gcacctcgcg ctcaaaggct acaggggcct cttcttcttc ttcaatctcc 15240
tcttccataa gggcctcccc ttcttcttct tctggcggcg gtgggggagg ggggacacgg 15300
cggcgacgac ggcgcaccgg gaggcggtcg acaaagcgct cgatcatctc cccgcggcga 15360
cggcgcatgg tctcggtgac ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg 15420
cccgtcatgt cccggttatg ggttggcggg gggctgccat gcggcaggga tacggcgcta 15480
acgatgcatc tcaacaattg ttgtgtaggt actccgccgc cgagggacct gagcgagtcc 15540
gcatcgaccg gatcggaaaa cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt 15600
aggctgagca ccgtggcggg cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg 15660
ctgctgatga tgtaattaaa gtaggcggtc ttgagacggc ggatggtcga cagaagcacc 15720
atgtccttgg gtccggcctg ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt 15780
tgacatcggc gcaggtcttt gtagtagtct tgcatgagcc tttctaccgg cacttcttct 15840
tctccttcct cttgtcctgc atctcttgca tctatcgctg cggcggcggc ggagtttggc 15900
cgtaggtggc gccctcttcc tcccatgcgt gtgaccccga agcccctcat cggctgaagc 15960
agggctaggt cggcgacaac gcgctcggct aatatggcct gctgcacctg cgtgagggta 16020
gactggaagt catccatgtc cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg 16080
cagttggcca taacggacca gttaacggtc tggtgacccg gctgcgagag ctcggtgtac 16140
ctgagacgcg agtaagccct cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac 16200
tggtatccca ccaaaaagtg cggcggcggc tggcggtaga ggggccagcg tagggtggcc 16260
ggggctccgg gggcgagatc ttccaacata aggcgatgat atccgtagat gtacctggac 16320
atccaggtga tgccggcggc ggtggtggag gcgcgcggaa agtcgcggac gcggttccag 16380
atgttgcgca gcggcaaaaa gtgctccatg gtcgggacgc tctggccggt caggcgcgcg 16440
caatcgttga cgctctagac cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg 16500
tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag ccccgtatcc 16560
ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc 16620
agacaacggg ggagtgctcc ttttggcttc cttccaggcg cggcggctgc tgcgctagct 16680
tttttggcca ctggccgcgc gcagcgtaag cggttaggct ggaaagcgaa agcattaagt 16740
ggctcgctcc ctgtagccgg agggttattt tccaagggtt gagtcgcggg acccccggtt 16800
cgagtctcgg accggccgga ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc 16860
ccgcttgcaa attcctccgg aaacagggac gagccccttt tttgcttttc ccagatgcat 16920
ccggtgctgc ggcagatgcg cccccctcct cagcagcggc aagagcaaga gcagcggcag 16980
acatgcaggg caccctcccc tcctcctacc gcgtcaggag gggcgacatc cgcggttgac 17040
gcggcagcag atggtgatta cgaacccccg cggcgccggg cccggcacta cctggacttg 17100
gaggagggcg agggcctggc gcggctagga gcgccctctc ctgagcggta cccaagggtg 17160
cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc 17220
gagggagagg agcccgagga gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg 17280
catggcctga atcgcgagcg gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc 17340
gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc tggtaaccgc atacgagcag 17400
acggtgaacc aggagattaa ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg 17460
gcgcgcgagg aggtggctat aggactgatg catctgtggg actttgtaag cgcgctggag 17520
caaaacccaa atagcaagcc gctcatggcg cagctgttcc ttatagtgca gcacagcagg 17580
gacaacgagg cattcaggga tgcgctgcta aacatagtag agcccgaggg ccgctggctg 17640
ctcgatttga taaacatcct gcagagcata gtggtgcagg agcgcagctt gagcctggct 17700
gacaaggtgg ccgccatcaa ctattccatg cttagcctgg gcaagtttta cgcccgcaag 17760
atataccata ccccttacgt tcccatagac aaggaggtaa agatcgaggg gttctacatg 17820
cgcatggcgc tgaaggtgct taccttgagc gacgacctgg gcgtttatcg caacgagcgc 17880
atccacaagg ccgtgagcgt gagccggcgg cgcgagctca gcgaccgcga gctgatgcac 17940
agcctgcaaa gggccctggc tggcacgggc agcggcgata gagaggccga gtcctacttt 18000
gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg ccctggaggc agctggggcc 18060
ggacctgggc tggcggtggc acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat 18120
gacgaggacg atgagtacga gccagaggac ggcgagtact aagcggtgat gtttctgatc 18180
agatgatgca agacgcaacg gacccggcgg tgcgggcggc gctgcagagc cagccgtccg 18240
gccttaactc cacggacgac tggcgccagg tcatggaccg catcatgtcg ctgactgcgc 18300
gcaatcctga cgcgttccgg cagcagccgc aggccaaccg gctctccgca attctggaag 18360
cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc 18420
tggccgaaaa cagggccatc cggcccgacg aggccggcct ggtctacgac gcgctgcttc 18480
agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa cctggaccgg ctggtggggg 18540
atgtgcgcga ggccgtggcg cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca 18600
tggttgcact aaacgccttc ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg 18660
actacaccaa ctttgtgagc gcactgcggc taatggtgac tgagacaccg caaagtgagg 18720
tgtaccagtc tgggccagac tattttttcc agaccagtag acaaggcctg cagaccgtaa 18780
acctgagcca ggctttcaaa aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg 18840
accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag 18900
cgcccttcac ggacagtggc agcgtgtccc gggacacata cctaggtcac ttgctgacac 18960
tgtaccgcga ggccataggt caggcgcatg tggacgagca tactttccag gagattacaa 19020
gtgtcagccg cgcgctgggg caggaggaca cgggcagcct ggaggcaacc ctaaactacc 19080
tgctgaccaa ccggcggcag aagatcccct cgttgcacag tttaaacagc gaggaggagc 19140
gcattttgcg ctacgtgcag cagagcgtga gccttaacct gatgcgcgac ggggtaacgc 19200
ccagcgtggc gctggacatg accgcgcgca acatggaacc gggcatgtat gcctcaaacc 19260
ggccgtttat caaccgccta atggactact tgcatcgcgc ggccgccgtg aaccccgagt 19320
atttcaccaa tgccatcttg aacccgcact ggctaccgcc ccctggtttc tacaccgggg 19380
gattcgaggt gcccgagggt aacgatggat tcctctggga cgacatagac gacagcgtgt 19440
tttccccgca accgcagacc ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc 19500
tgcgaaagga aagcttccgc aggccaagca gcttgtccga tctaggcgct gcggccccgc 19560
ggtcagatgc tagtagccca tttccaagct tgatagggtc tcttaccagc actcgcacca 19620
cccgcccgcg cctgctgggc gaggaggagt acctaaacaa ctcgctgctg cagccgcagc 19680
gcgaaaaaaa cctgcctccg gcatttccca acaacgggat agagagccta gtggacaaga 19740
tgagtagatg gaagacgtac gcgcaggagc acagggacgt gccaggcccg cgcccgccca 19800
cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg ggaggacgat gactcggcag 19860
acgacagcag cgtcctggat ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca 19920
ggctggggag aatgttttaa aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg 19980
ccatggcacc gagcgttggt tttcttgtat tccccttagt atgcggcgcg cggcgatgta 20040
tgaggaaggt cctcctccct cctacgagag tgtggtgagc gcggcgccag tggcggcggc 20100
gctgggttct cccttcgatg ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg 20160
gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat tcgacaccac 20220
ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca tccctgaact accagaacga 20280
ccacagcaac tttctgacca cggtcattca aaacaatgac tacagcccgg gggaggcaag 20340
cacacagacc atcaatcttg acgaccggtc gcactggggc ggcgacctga aaaccatcct 20400
gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta aggcgcgggt 20460
gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga 20520
gttcacgctg cccgagggca actactccga gaccatgacc atagacctta tgaacaacgc 20580
gatcgtggag cactacttga aagtgggcag acagaacggg gttctggaaa gcgacatcgg 20640
ggtaaagttt gacacccgca acttcagact ggggtttgac cccgtcactg gtcttgtcat 20700
gcctggggta tatacaaacg aagccttcca tccagacatc attttgctgc caggatgcgg 20760
ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt 20820
ccaggagggc tttaggatca cctacgatga tctggagggt ggtaacattc ccgcactgtt 20880
ggatgtggac gcctaccagg cgagcttgaa agatgacacc gaacagggcg ggggtggcgc 20940
aggcggcagc aacagcagtg gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc 21000
aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct ttgccacacg 21060
ggctgaggag aagcgcgctg aggccgaagc agcggccgaa gctgccgccc ccgctgcgca 21120
acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag aggacagcaa 21180
gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc gcagctggta 21240
ccttgcatac aactacggcg accctcagac cggaatccgc tcatggaccc tgctttgcac 21300
tcctgacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca tgatgcaaga 21360
ccccgtgacc ttccgctcca cgcgccagat cagcaacttt ccggtggtgg gcgccgagct 21420
gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc aactcatccg 21480
ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg 21540
cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg 21600
gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta ctgacgccag 21660
acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc gcgtcctatc 21720
gagccgcact ttttgagcaa gcatgtccat ccttatatcg cccagcaata acacaggctg 21780
gggcctgcgc ttcccaagca agatgtttgg cggggccaag aagcgctccg accaacaccc 21840
agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg 21900
gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag gaggcgcgca actacacgcc 21960
cacgccgcca ccagtgtcca cagtggacgc ggccattcag accgtggtgc gcggagcccg 22020
gcgctatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc gccgccgacc 22080
cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg 22140
acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt attgtcactg tgccccccag 22200
gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga ctcagggtcg 22260
caggggcaac gtgtattggg tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac 22320
ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact gttgtatgta 22380
tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatcaaag aagagatgct 22440
ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg attacaagcc 22500
ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga 22560
ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt 22620
aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg cccggtgagc gctccacccg 22680
cacctacaag cgcgtgtatg atgaggtgta cggcgacgag gacctgcttg agcaggccaa 22740
cgagcgcctc ggggagtttg cctacggaaa gcggcataag gacatgctgg cgttgccgct 22800
ggacgagggc aacccaacac ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc 22860
gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag tctggtgact tggcacccac 22920
cgtgcagctg atggtaccca agcgccagcg actggaagat gtcttggaaa aaatgaccgt 22980
ggaacctggg ctggagcccg aggtccgcgt gcggccaatc aagcaggtgg cgccgggact 23040
gggcgtgcag accgtggacg ttcagatacc cactaccagt agcaccagta ttgccaccgc 23100
cacagagggc atggagacac aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt 23160
gcaggcggtc gctgcggccg cgtccaagac ctctacggag gtgcaaacgg acccgtggat 23220
gtttcgcgtt tcagcccccc ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc 23280
gctactgccc gaatatgccc tacatccttc cattgcgcct acccccggct atcgtggcta 23340
cacctaccgc cccagaagac gagcaactac ccgacgccga accaccactg gaacccgccg 23400
ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga 23460
aggaggcagg accctggtgc tgccaacagc gcgctaccac cccagcatcg tttaaaagcc 23520
ggtctttgtg gttcttgcag atatggccct cacctgccgc ctccgtttcc cggtgccggg 23580
attccgagga agaatgcacc gtaggagggg catggccggc cacggcctga cgggcggcat 23640
gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct 23700
gcccctcctt attccactga tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt 23760
ggccttgcag gcgcagagac actgattaaa aacaagttgc atgtggaaaa atcaaaataa 23820
aaagtctgga ctctcacgct cgcttggtcc tgtaactatt ttgtagaatg gaagacatca 23880
actttgcgtc tctggccccg cgacacggct cgcgcccgtt catgggaaac tggcaagata 23940
tcggcaccag caatatgagc ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta 24000
aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc ctggaacagc agcacaggcc 24060
agatgctgag ggataagttg aaagagcaaa atttccaaca aaaggtggta gatggcctgg 24120
cctctggcat tagcggggtg gtggacctgg ccaaccaggc agtgcaaaat aagattaaca 24180
gtaagcttga tccccgccct cccgtagagg agcctccacc ggccgtggag acagtgtctc 24240
cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa 24300
tagacgagcc tccctcgtac gaggaggcac taaagcaagg cctgcccacc acccgtccca 24360
tcgcgcccat ggctaccgga gtgctgggcc agcacacacc cgtaacgctg gacctgcctc 24420
cccccgccga cacccagcag aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc 24480
gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag 24540
ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg tctgggggtg caatccctga 24600
agcgccgacg atgcttctga atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg 24660
tcgccgccag aggagctgct gagccgccgc gcgcccgctt tccaagatgg ctaccccttc 24720
gatgatgccg cagtggtctt acatgcacat ctcgggccag gacgcctcgg agtacctgag 24780
ccccgggctg gtgcagtttg cccgcgccac cgagacgtac ttcagcctga ataacaagtt 24840
tagaaacccc acggtggcgc ctacgcacga cgtgaccaca gaccggtccc agcgtttgac 24900
gctgcggttc atccctgtgg accgtgagga tactgcgtac tcgtacaagg cgcggttcac 24960
cctagctgtg ggtgataacc gtgtgctgga catggcttcc acgtactttg acatccgcgg 25020
cgtgctggac aggggcccta cttttaagcc ctactctggc actgcctaca acgccctggc 25080
tcccaagggt gccccaaatc cttgcgaatg ggatgaagct gctactgctc ttgaaataaa 25140
cctagaagaa gaggacgatg acaacgaaga cgaagtagac gagcaagctg agcagcaaaa 25200
aactcacgta tttgggcagg cgccttattc tggtataaat attacaaagg agggtattca 25260
aataggtgtc gaaggtcaaa cacctaaata tgccgataaa acatttcaac ctgaacctca 25320
aataggagaa tctcagtggt acgaaactga aattaatcat gcagctggga gagtccttaa 25380
aaagactacc ccaatgaaac catgttacgg ttcatatgca aaacccacaa atgaaaatgg 25440
agggcaaggc attcttgtaa agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca 25500
atttttctca actactgagg cgaccgcagg caatggtgat aacttgactc ctaaagtggt 25560
attgtacagt gaagatgtag atatagaaac cccagacact catatttctt acatgcccac 25620
tattaaggaa ggtaactcac gagaactaat gggccaacaa tctatgccca acaggcctaa 25680
ttacattgct tttagggaca attttattgg tctaatgtat tacaacagca cgggtaatat 25740
gggtgttctg gcgggccaag catcgcagtt gaatgctgtt gtagatttgc aagacagaaa 25800
cacagagctt tcataccagc ttttgcttga ttccattggt gatagaacca ggtacttttc 25860
tatgtggaat caggctgttg acagctatga tccagatgtt agaattattg aaaatcatgg 25920
aactgaagat gaacttccaa attactgctt tccactggga ggtgtgatta atacagagac 25980
tcttaccaag gtaaaaccta aaacaggtca ggaaaatgga tgggaaaaag atgctacaga 26040
attttcagat aaaaatgaaa taagagttgg aaataatttt gccatggaaa tcaatctaaa 26100
tgccaacctg tggagaaatt tcctgtactc caacatagcg ctgtatttgc ccgacaagct 26160
aaagtacagt ccttccaacg taaaaatttc tgataaccca aacacctacg actacatgaa 26220
caagcgagtg gtggctcccg ggttagtgga ctgctacatt aaccttggag cacgctggtc 26280
ccttgactat atggacaacg tcaacccatt taaccaccac cgcaatgctg gcctgcgcta 26340
ccgctcaatg ttgctgggca atggtcgcta tgtgcccttc cacatccagg tgcctcagaa 26400
gttctttgcc attaaaaacc tccttctcct gccgggctca tacacctacg agtggaactt 26460
caggaaggat gttaacatgg ttctgcagag ctccctagga aatgacctaa gggttgacgg 26520
agccagcatt aagtttgata gcatttgcct ttacgccacc ttcttcccca tggcccacaa 26580
caccgcctcc acgcttgagg ccatgcttag aaacgacacc aacgaccagt cctttaacga 26640
ctatctctcc gccgccaaca tgctctaccc tatacccgcc aacgctacca acgtgcccat 26700
atccatcccc tcccgcaact gggcggcttt ccgcggctgg gccttcacgc gccttaagac 26760
taaggaaacc ccatcactgg gctcgggcta cgacccttat tacacctact ctggctctat 26820
accctaccta gatggaacct tttacctcaa ccacaccttt aagaaggtgg ccattacctt 26880
tgactcttct gtcagctggc ctggcaatga ccgcctgctt acccccaacg agtttgaaat 26940
taagcgctca gttgacgggg agggttacaa cgttgcccag tgtaacatga ccaaagactg 27000
gttcctggta caaatgctag ctaactacaa cattggctac cagggcttct atatcccaga 27060
gagctacaag gaccgcatgt actccttctt tagaaacttc cagcccatga gccgtcaggt 27120
ggtggatgat actaaataca aggactacca acaggtgggc atcctacacc aacacaacaa 27180
ctctggattt gttggctacc ttgcccccac catgcgcgaa ggacaggcct accctgctaa 27240
cttcccctat ccgcttatag gcaagaccgc agttgacagc attacccaga aaaagtttct 27300
ttgcgatcgc accctttggc gcatcccatt ctccagtaac tttatgtcca tgggcgcact 27360
cacagacctg ggccaaaacc ttctctacgc caactccgcc cacgcgctag acatgacttt 27420
tgaggtggat cccatggacg agcccaccct tctttatgtt ttgtttgaag tctttgacgt 27480
ggtccgtgtg caccggccgc accgcggcgt catcgaaacc gtgtacctgc gcacgccctt 27540
ctcggccggc aacgccacaa cataaagaag caagcaacat caacaacagc tgccgccatg 27600
ggctccagtg agcaggaact gaaagccatt gtcaaagatc ttggttgtgg gccatatttt 27660
ttgggcacct atgacaagcg ctttccaggc tttgtttctc cacacaagct cgcctgcgcc 27720
atagtcaata cggccggtcg cgagactggg ggcgtacact ggatggcctt tgcctggaac 27780
ccgcactcaa aaacatgcta cctctttgag ccctttggct tttctgacca gcgactcaag 27840
caggtttacc agtttgagta cgagtcactc ctgcgccgta gcgccattgc ttcttccccc 27900
gaccgctgta taacgctgga aaagtccacc caaagcgtac aggggcccaa ctcggccgcc 27960
tgtggactat tctgctgcat gtttctccac gcctttgcca actggcccca aactcccatg 28020
gatcacaacc ccaccatgaa ccttattacc ggggtaccca actccatgct caacagtccc 28080
caggtacagc ccaccctgcg tcgcaaccag gaacagctct acagcttcct ggagcgccac 28140
tcgccctact tccgcagcca cagtgcgcag attaggagcg ccacttcttt ttgtcacttg 28200
aaaaacatgt aaaaataatg tactagagac actttcaata aaggcaaatg cttttatttg 28260
tacactctcg ggtgattatt tacccccacc cttgccgtct gcgccgttta aaaatcaaag 28320
gggttctgcc gcgcatcgct atgcgccact ggcagggaca cgttgcgata ctggtgttta 28380
gtgctccact taaactcagg cacaaccatc cgcggcagct cggtgaagtt ttcactccac 28440
aggctgcgca ccatcaccaa cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag 28500
ttggggcctc cgccctgcgc gcgcgagttg cgatacacag ggttgcagca ctggaacact 28560
atcagcgccg ggtggtgcac gctggccagc acgctcttgt cggagatcag atccgcgtcc 28620
aggtcctccg cgttgctcag ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag 28680
ggcgcgtgcc caggctttga gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc 28740
ccggtctggg cgttaggata cagcgcctgc ataaaagcct tgatctgctt aaaagccacc 28800
tgagcctttg cgccttcaga gaagaacatg ccgcaagact tgccggaaaa ctgattggcc 28860
ggacaggccg cgtcgtgcac gcagcacctt gcgtcggtgt tggagatctg caccacattt 28920
cggccccacc ggttcttcac gatcttggcc ttgctagact gctccttcag cgcgcgctgc 28980
ccgttttcgc tcgtcacatc catttcaatc acgtgctcct tatttatcat aatgcttccg 29040
tgtagacact taagctcgcc ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc 29100
gtgggctcgt gatgcttgta ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat 29160
cgccccatca tcgtcacaaa ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc 29220
tcctcgttca gccaggtctt gcatacggcc gccagagctt ccacttggtc aggcagtagt 29280
ttgaagttcg cctttagatc gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc 29340
tccatgccct tctcccacgc agacacgatc ggcacactca gcgggttcat caccgtaatt 29400
tcactttccg cttcgctggg ctcttcctct tcctcttgcg tccgcatacc acgcgccact 29460
gggtcgtctt cattcagccg ccgcactgtg cgcttacctc ctttgccatg cttgattagc 29520
accggtgggt tgctgaaacc caccatttgt agcgccacat cttctctttc ttcctcgctg 29580
tccacgatta cctctggtga tggcgggcgc tcgggcttgg gagaagggcg cttctttttc 29640
ttcttgggcg caatggccaa atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc 29700
ggcaccagcg cgtcttgtga tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc 29760
cgcttttttg ggggcgcccg gggaggcggc ggcgacgggg acggggacga cacgtcctcc 29820
atggttgggg gacgtcgcgc cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc 29880
tcttcccgac tggccatttc cttctcctat aggcagaaaa agatcatgga gtcagtcgag 29940
aagaaggaca gcctaaccgc cccctctgag ttcgccacca ccgcctccac cgatgccgcc 30000
aacgcgccta ccaccttccc cgtcgaggca cccccgcttg aggaggagga agtgattatc 30060
gagcaggacc caggttttgt aagcgaagac gacgaggacc gctcagtacc aacagaggat 30120
aaaaagcaag accaggacaa cgcagaggca aacgaggaac aagtcgggcg gggggacgaa 30180
aggcatggcg actacctaga tgtgggagac gacgtgctgt tgaagcatct gcagcgccag 30240
tgcgccatta tctgcgacgc gttgcaagag cgcagcgatg tgcccctcgc catagcggat 30300
gtcagccttg cctacgaacg ccacctattc tcaccgcgcg taccccccaa acgccaagaa 30360
aacggcacat gcgagcccaa cccgcgcctc aacttctacc ccgtatttgc cgtgccagag 30420
gtgcttgcca cctatcacat ctttttccaa aactgcaaga tacccctatc ctgccgtgcc 30480
aaccgcagcc gagcggacaa gcagctggcc ttgcggcagg gcgctgtcat acctgatatc 30540
gcctcgctca acgaagtgcc aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg 30600
gcaaacgctc tgcaacagga aaacagcgaa aatgaaagtc actctggagt gttggtggaa 30660
ctcgagggtg acaacgcgcg cctagccgta ctaaaacgca gcatcgaggt cacccacttt 30720
gcctacccgg cacttaacct accccccaag gtcatgagca cagtcatgag tgagctgatc 30780
gtgcgccgtg cgcagcccct ggagagggat gcaaatttgc aagaacaaac agaggagggc 30840
ctacccgcag ttggcgacga gcagctagcg cgctggcttc aaacgcgcga gcctgccgac 30900
ttggaggagc gacgcaaact aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc 30960
atgcagcggt tctttgctga cccggagatg cagcgcaagc tagaggaaac attgcactac 31020
acctttcgac agggctacgt acgccaggcc tgcaagatct ccaacgtgga gctctgcaac 31080
ctggtctcct accttggaat tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc 31140
acgctcaagg gcgaggcgcg ccgcgactac gtccgcgact gcgtttactt atttctatgc 31200
tacacctggc agacggccat gggcgtttgg cagcagtgct tggaggagtg caacctcaag 31260
gagctgcaga aactgctaaa gcaaaacttg aaggacctat ggacggcctt caacgagcgc 31320
tccgtggccg cgcacctggc ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa 31380
cagggtctgc cagacttcac cagtcaaagc atgttgcaga actttaggaa ctttatccta 31440
gagcgctcag gaatcttgcc cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt 31500
aagtaccgcg aatgccctcc gccgctttgg ggccactgct accttctgca gctagccaac 31560
taccttgcct accactctga cataatggaa gacgtgagcg gtgacggtct actggagtgt 31620
cactgtcgct gcaacctatg caccccgcac cgctccctgg tttgcaattc gcagctgctt 31680
aacgaaagtc aaattatcgg tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc 31740
gcggctccgg ggttgaaact cactccgggg ctgtggacgt cggcttacct tcgcaaattt 31800
gtacctgagg actaccacgc ccacgagatt aggttctacg aagaccaatc ccgcccgcca 31860
aatgcggagc ttaccgcctg cgtcattacc cagggccaca ttcttggcca attgcaagcc 31920
atcaacaaag cccgccaaga gtttctgcta cgaaagggac ggggggttta cttggacccc 31980
cagtccggcg aggagctcaa cccaatcccc ccgccgccgc agccctatca gcagcagccg 32040
cgggcccttg cttcccagga tggcacccaa aaagaagctg cagctgccgc cgccacccac 32100
ggacgaggag gaatactggg acagtcaggc agaggaggtt ttggacgagg aggaggagga 32160
catgatggaa gactgggaga gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga 32220
cgaaacaccg tcaccctcgg tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg 32280
ttccagcatg gctacaacct ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc 32340
caaccgtaga tgggacacca ctggaaccag ggccggtaag tccaagcagc cgccgccgtt 32400
agcccaagag caacaacagc gccaaggcta ccgctcatgg cgcgggcaca agaacgccat 32460
agttgcttgc ttgcaagact gtgggggcaa catctccttc gcccgccgct ttcttctcta 32520
ccatcacggc gtggccttcc cccgtaacat cctgcattac taccgtcatc tctacagccc 32580
atactgcacc ggcggcagcg gcagcggcag caacagcagc ggccacacag aagcaaaggc 32640
gaccggatag caagactctg acaaagccca agaaatccac agcggcggca gcagcaggag 32700
gaggagcgct gcgtctggcg cccaacgaac ccgtatcgac ccgcgagctt agaaacagga 32760
tttttcccac tctgtatgct atatttcaac agagcagggg ccaagaacaa gagctgaaaa 32820
taaaaaacag gtctctgcga tccctcaccc gcagctgcct gtatcacaaa agcgaagatc 32880
agcttcggcg cacgctggaa gacgcggagg ctctcttcag taaatactgc gcgctgactc 32940
ttaaggacta gtttcgcgcc ctttctcaaa tttaagcgcg aaaactacgt catctccagc 33000
ggccacaccc ggcgccagca cctgtcgtca gcgccattat gagcaaggaa attcccacgc 33060
cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc caagactact 33120
caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc aacggaatcc 33180
gcgcccaccg aaaccgaatt ctcttggaac aggcggctat taccaccaca cctcgtaata 33240
accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc gctcccacca 33300
ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca ggggcgcagc 33360
ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact cacctgacaa 33420
tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc 33480
cggacgggac atttcagatc ggcggcgccg gccgtccttc attcacgcct cgtcaggcaa 33540
tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga actctgcaat 33600
ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct cccggccact 33660
atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac ggctacgact 33720
gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc 33780
acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc gaggatcata 33840
tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc cgtagcctga 33900
ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc tgtgttctca 33960
ctgtgatttg caactgtcct aaccttggat tacatcaaga tctttgttgc catctctgtg 34020
ctgagtataa taaatacaga aattaaaata tactggggct cctatcgcca tcctgtaaac 34080
gccaccgtct tcacccgccc aagcaaacca aggcgaacct tacctggtac ttttaacatc 34140
tctccctctg tgatttacaa cagtttcaac ccagacggag tgagtctacg agagaacctc 34200
tccgagctca gctactccat cagaaaaaac accaccctcc ttacctgccg ggaacgtacg 34260
agtgcgtcac cggccgctgc accacaccta ccgcctgacc gtaaaccaga ctttttccgg 34320
acagacctca ataactctgt ttaccagaac aggaggtgag cttagaaaac ccttagggta 34380
ttaggccaaa ggcgcagcta ctgtggggtt tatgaacaat tcaagcaact ctacgggcta 34440
ttctaattca ggtttctcta gaaatggacg gaattattac agagcagcgc ctgctagaaa 34500
gacgcagggc agcggccgag caacagcgca tgaatcaaga gctccaagac atggttaact 34560
tgcaccagtg caaaaggggt atcttttgtc tggtaaagca ggccaaagtc acctacgaca 34620
gtaataccac cggacaccgc cttagctaca agttgccaac caagcgtcag aaattggtgg 34680
tcatggtggg agaaaagccc attaccataa ctcagcactc ggtagaaacc gaaggctgca 34740
ttcactcacc ttgtcaagga cctgaggatc tctgcaccct tattaagacc ctgtgcggtc 34800
tcaaagatct tattcccttt aactaataaa aaaaaataat aaagcatcac ttacttaaaa 34860
tcagttagca aatttctgtc cagtttattc agcagcacct ccttgccctc ctcccagctc 34920
tggtattgca gcttcctcct ggctgcaaac tttctccaca atctaaatgg aatgtcagtt 34980
tcctcctgtt cctgtccatc cgcacccact atcttcatgt tgttgcagat gaagcgcgca 35040
agaccgtctg aagatacctt caaccccgtg tatccatatg acacggaaac cggtcctcca 35100
actgtgcctt ttcttactcc tccctttgta tcccccaatg ggtttcaaga gagtccccct 35160
ggggtactct ctttgcgcct atccgaacct ctagttacct ccaatggcat gcttgcgctc 35220
aaaatgggca acggcctctc tctggacgag gccggcaacc ttacctccca aaatgtaacc 35280
actgtgagcc cacctctcaa aaaaaccaag tcaaacataa acctggaaat atctgcaccc 35340
ctcacagtta cctcagaagc cctaactgtg gctgccgccg cacctctaat ggtcgcgggc 35400
aacacactca ccatgcaatc acaggccccg ctaaccgtgc acgactccaa acttagcatt 35460
gccacccaag gacccctcac agtgtcagaa ggaaagctag ccctgcaaac atcaggcccc 35520
ctcaccacca ccgatagcag tacccttact atcactgcct caccccctct aactactgcc 35580
actggtagct tgggcattga cttgaaagag cccatttata cacaaaatgg aaaactagga 35640
ctaaagtacg gggctccttt gcatgtaaca gacgacctaa acactttgac cgtagcaact 35700
ggtccaggtg tgactattaa taatacttcc ttgcaaacta aagttactgg agccttgggt 35760
tttgattcac aaggcaatat gcaacttaat gtagcaggag gactaaggat tgattctcaa 35820
aacagacgcc ttatacttga tgttagttat ccgtttgatg ctcaaaacca actaaatcta 35880
agactaggac agggccctct ttttataaac tcagcccaca acttggatat taactacaac 35940
aaaggccttt acttgtttac agcttcaaac aattccaaaa agcttgaggt taacctaagc 36000
actgccaagg ggttgatgtt tgacgctaca gccatagcca ttaatgcagg agatgggctt 36060
gaatttggtt cacctaatgc accaaacaca aatcccctca aaacaaaaat tggccatggc 36120
ctagaatttg attcaaacaa ggctatggtt cctaaactag gaactggcct tagttttgac 36180
agcacaggtg ccattacagt aggaaacaaa aataatgata agctaacttt gtggaccaca 36240
ccagctccat ctcctaactg tagactaaat gcagagaaag atgctaaact cactttggtc 36300
ttaacaaaat gtggcagtca aatacttgct acagtttcag ttttggctgt taaaggcagt 36360
ttggctccaa tatctggaac agttcaaagt gctcatctta ttataagatt tgacgaaaat 36420
ggagtgctac taaacaattc cttcctggac ccagaatatt ggaactttag aaatggagat 36480
cttactgaag gcacagccta tacaaacgct gttggattta tgcctaacct atcagcttat 36540
ccaaaatctc acggtaaaac tgccaaaagt aacattgtca gtcaagttta cttaaacgga 36600
gacaaaacta aacctgtaac actaaccatt acactaaacg gtacacagga aacaggagac 36660
acaactccaa gtgcatactc tatgtcattt tcatgggact ggtctggcca caactacatt 36720
aatgaaatat ttgccacatc ctcttacact ttttcataca ttgcccaaga ataaagaatc 36780
gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcga atcatttttc 36840
attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac 36900
tcacagaacc ctagtattca acctgccacc tccctcccaa cacacagagt acacagtcct 36960
ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt 37020
tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa taaactcccc 37080
gggcagctca cttaagttca tgtcgctgtc cagctgctga gccacaggct gctgtccaac 37140
ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg tagagtcata 37200
atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact gctgccgccg 37260
ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga ttcgcaccgc 37320
ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct cacttaaatc 37380
agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct 37440
gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc acaagcgcag 37500
gtagattaag tggcgacccc tcataaacac gctggacata aacattacct cttttggcat 37560
gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg cgccatccac 37620
caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca gggaaccggg 37680
actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca tgctcgtcat 37740
gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga ttacaagctc 37800
ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg taaatcccac 37860
actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg 37920
cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag gaggtagacg 37980
atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc 38040
aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa 38100
cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg tagtatatcc 38160
actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact ccttcatgcg 38220
ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa cctacacatt 38280
cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg tttttttttt 38340
tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct 38400
ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt aagatgttgc 38460
acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag gctaaaccct 38520
tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa ataattctca 38580
tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc ggccattgta 38640
aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat gattgcaaaa 38700
attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca aaaataccgc 38760
gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct gcacggacca 38820
gcgcggccac ttccccgcca ggaaccttga caaaagaacc cacactgatt atgacacgca 38880
tactcggagc tatgctaacc agcgtagccc cgatgtaagc tttgttgcat gggcggcgat 38940
ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 39000
tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 39060
accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 39120
aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 39180
gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 39240
ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 39300
gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc 39360
gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 39420
aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 39480
gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 39540
aaaacctatt aaaaaaacac cactcgacac ggcacataac ttcgtatagc atacattata 39600
cgaagttatc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat 39660
ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg 39720
cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc 39780
gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag 39840
ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa 39900
actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt attgatgatg 39960
cctccggggt ccactgcaat taataacttc gtatagcata cattatacga agttatttaa 40020
ttaagggcgg ccgcacgggc catcgatggg gatcctaact ttaaataatg ccaattattt 40080
aaagttacca actattttgt ccgcccacag gtaccctgtg aatgcgcaaa ccaacccttg 40140
gcagaacata tccatcgcgt ccgccatctc cagcagccgc acgcggcgca tctcgggcag 40200
cgttgggtcc tggccacggg tgcgcatgat cgtgctcctg tcgttgagga cccggctagg 40260
ctggcggggt tgccttactg gttagcagaa tgaatcaccg atacgcgagc gaacgtgaag 40320
cgactgctgc tgcaaaacgt ctgcgacctg agcaacaaca tgaatggtct tcggtttccg 40380
tgtttcgtaa agtctggaaa cgcggaagtc agcgccctgc accattatgt tccggaacgt 40440
acgaagcatg ctaattttgt gttactcatg cattatcgtt tcagacccac ctcccaaccc 40500
cgaggggacc cagagagggc ctatttccca tgattccttc atatttgcat atacgataca 40560
aggctgttag agagataatt agaattaatt tgactgtaaa cacaaagata ttagtacaaa 40620
atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa ttatgtttta 40680
aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg gctttatata 40740
tcttgtggaa aggacgaaac acctaattgc agtggacccc gggttttaga gctagaaata 40800
gcaagttaaa ataaggctag tccgttatca acttgaaaaa gtggcaccga gtcggtgctt 40860
ttttaagctt gaattcacac ctcgagtaag gatccgcccc tctccctccc ccccccctaa 40920
cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc 40980
caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac 41040
gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt 41100
gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg 41160
caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata 41220
agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga 41280
aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt 41340
accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc 41400
gaggttaaaa aaacgtctag gccccccgaa ccacggggac gtggttttcc tttgaaaaac 41460
acgatgataa tatggccaca accatggtga gcaagggcga ggagctgttc accggggtgg 41520
tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg 41580
agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca 41640
agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca 41700
gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct 41760
acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg 41820
tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg 41880
aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata 41940
tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg 42000
aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc 42060
ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca 42120
acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg 42180
gcatggacga gctgtacaag taaagcggcc gcgactctag atcataatca gccataccac 42240
atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 42300
taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 42360
aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 42420
tttgtccaaa ctcatcaatg tatcttaaat cgaattggtc aggtggcact tttcggggaa 42480
atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca 42540
tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc 42600
aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc 42660
acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt 42720
acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt 42780
ctccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtgttgacg 42840
ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact 42900
caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg 42960
ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga 43020
aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg 43080
aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa 43140
tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac 43200
aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc 43260
cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca 43320
ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga 43380
gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta 43440
agcattggta actgtcagac caagtttaat taactttaaa taatgccaat tatttaaagt 43500
taatccgcgg agaagcttct cgaccaattc tcatgtttga cagcttatca tcgaatttct 43560
gccattcatc cgcttattat cacttattca ggcgtagcaa ccaggcgttt aagggcacca 43620
ataactgcct taaaaaaatt acgccccgcc ctgccactca tcgcagtact gttgtaattc 43680
attaagcatt ctgccgacat ggaagccatc acagacggca tgatgaacct gaatcgccag 43740
cggcatcagc accttgtcgc cttgcgtata atatttgccc atggtgaaaa cgggggcgaa 43800
gaagttgtcc atattggcca cgtttaaatc aaaactggtg aaactcaccc agggattggc 43860
tgagacgaaa aacatattct caataaaccc tttagggaaa taggccaggt tttcaccgta 43920
acacgccaca tcttgcgaat atatgtgtag aaactgccgg aaatcgtcgt ggtattcact 43980
ccagagcgat gaaaacgttt cagtttgctc atggaaaacg gtgtaacaag ggtgaacact 44040
atcccatatc accagctcac cgtctttcat tgccatacgg aattccggat gagcattcat 44100
caggcgggca agaatgtgaa taaaggccgg ataaaacttg tgcttatttt tctttacggt 44160
ctttaaaaag gccgtaatat ccagctgaac ggtctggtta taggtacatt gagcaactga 44220
ctgaaatgcc tcaaaatgtt ctttacgatg ccattgggat atatcaacgg tggtatatcc 44280
agtgattttt ttctccattt tagcttcctt agctcctgaa aatctcgata actcaaaaaa 44340
tacgcccg 44348
<210> 41
<211> 38742
<212> DNA
<213> 人工序列
<220>
<223> pBWH-D64M-GFP
<400> 41
agcggacttt agacccggaa acggccgatt ttcccgcggc cacgcccgga tatgaggtaa 60
ttctgggcgg atgcaagtga aattaggtca ttttggcgcc aaaactgaat gaggaagtga 120
aaagtgaaaa atacctgtcc cgcccagggc ggaatattta ccgagggccg agagactttg 180
accgattacg tggggtttcg attgcggtgt ttttttcgcg agaaggtaaa ctgcccactt 240
ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa 300
atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta 360
catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg 420
gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg 480
gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc 540
attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctggttt 600
agtgaaccgt cagatccgct agcgctaccg gactcagatc tcgagctcaa gcttcgaatt 660
ctgcagtcga cggtaccgcg ggcccgggat ccaccggtcg ccaccatggt gagcaagggc 720
gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc 780
cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg 840
aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg 900
acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc 960
aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc 1020
aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag 1080
ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac 1140
tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac 1200
ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag 1260
aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag 1320
tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg 1380
accgccgccg ggatcactct cggcatggac gagctgtaca agtaaagcgg ccgcgactct 1440
agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 1500
acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 1560
cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 1620
tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttaa ggcgtaaatt 1680
gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt 1740
aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg 1800
ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc 1860
aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca 1920
agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga 1980
tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa 2040
ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc 2100
gccgcgctta atgcgccgct acagggcgcg tcaggtggca cttttcgggg aaatgtgcgc 2160
ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa 2220
taaccctgat aaatgcttca ataatattga aaaaggaaga gtcctgaggc ggaaagaacc 2280
agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa 2340
gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc 2400
cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc 2460
taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct 2520
gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga 2580
agtagtgagg aggctttttt ggagggggtg gggtaccagg taagtgtacc caattcgccc 2640
tatagtgagt cgtattacaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac 2700
cctggcgtta cccaacgtga gaccagacca cctggtgatg gcctgtaccg ggaccgagtt 2760
cagctccagt ggggaggaca cagattagag gtaggtttga gtagtgggcg tggctaatgt 2820
gagtataaag gcgggtgtct tacgagggtc tttttgcttt tctgcagaca tcatgaacgg 2880
gaccggcggg gccttcgaag gggggctttt tagcccttat ttgacaaccc gcctgccggg 2940
atgggccgga gttcgtcaga atgtgatggg atctacggtg gatgggcgtc cagtgcttcc 3000
agcaaattcc tcgaccatga cctacgcgac cgtggggagc tcgtcgcttg acagcaccgc 3060
cgcagccgcg gcagccgcag ccgccatgac agcgacgaga ctggcctcga gctatatgcc 3120
cagcagcggt agcagcccct ctgtgcccag ttccatcatc gccgaggaga aactgctggc 3180
cctgctggcc gagctggaag ccctgagccg ccagctggcc gccctgaccc agcaggtgtc 3240
cgatctccgc gagcaacagc agcagcaaaa taaatgaatt caataaacac agattctgat 3300
tcaaacagca aagcatcttt attatttatt ttttcgcgcg cggtaggccc tggtccacct 3360
ctcccgatca ttgagagtgc ggtggatttt ttccaggacc cggtagaggt gggattggat 3420
gttgaggtac atgggcatga gcccgtcccg ggggtggagg tagcaccact gcatggcctc 3480
gtgctctggg gtcgtgttgt agataatcca gtcatagcag gggcgctggg cgtggtgctg 3540
gatgatgtcc ttgaggagga gactgatggc cacggggagc cccttggtgt aggtgttggc 3600
aaagcggtta agctgggagg gatgcatgcg gggggagatg atgtgcagtt tggcctggat 3660
cttgaggttg gcgatgttgc cacccagatc ccgccggggg ttcatattgt gcaggaccac 3720
cagaacggtg tagcccgtgc acttggggaa cttatcatgc aacttggaag ggaatgcgtg 3780
gaagaatttg gagacgccct tgtgcccgcc caggttttcc atgcactcat ccatgatgat 3840
ggcaatgggc ccgtgggctg cggctttggc aaaaacgttt ctggggtcag agacatcata 3900
attatgctcc tgggtgagat catcataaga cattttaatg aatttggggc gaagggtgcc 3960
agattggggg acgatcgttc cctcgggccc cggggcgaag ttcccctcgc agatctgcat 4020
ctcccaggct ttcatctcgg agggggggat catgtccacc tgcggggcga tgaaaaaaac 4080
ggtttccggg gcgggggtga tgagctgcga ggagagcagg tttcttaaca gctgggactt 4140
gccgcacccg gtcgggccgt agatgacccc gatgacgggt tgcaggtggt agttcaagga 4200
gatgcagctg ccgtcgtccc ggaggagggg ggccacctcg ttgagcatgt ctctcacttg 4260
gaggttttcc cggacgagct cgccgaggag gcggtccccg cccagcgaga gcagctcttg 4320
cagggaagca aagtttttca ggggcttgag cccgtcggcc atgggcatct tggcaagggt 4380
ctgcgagagg agctccaggc ggtcccatag ctcggtgacg tgctctacgg catctcgatc 4440
cagcagactt cctcgtttcg ggggttggga cgactgcgac tgtagggcac gagacgatgg 4500
gcgtccagcg cggccagcgt catgtccttc cagggtctca gggtccgagt gagggtggtc 4560
tccgtcacgg tgaaggggtg ggccccgggc tgggcgcttg caagggtgcg cttgagactc 4620
atcctgctgg tgctgaaacg ggcacggtct tcgccctgcg cgtcggcgag atagcagttg 4680
accatgagct tgtagttaag ggcctcggcg gcgtggccct tggcacggag cttgcctttg 4740
gaagagcgcc cgcaggcggg acagaggagg gattgcaggg cgtagagctt gggtgcgaga 4800
aagacggact cgggagcgaa ggcgtccgct ccgcagtggg cgcagacggt ctcgcactcg 4860
acgagccagg tgagctcggg ctgctcgggg tcaaaaacca gttttccccc gttctttttg 4920
atgcgcttct tacctcgcgt ctccatgagt ctgtgtccgc gttcggtgac aaacaggctg 4980
tctgtgtccc cgtagacgga cttgattggc ctgtcctgca ggggcgtccc gcggtcctcc 5040
tcgtagagaa actcggacca ctctgagaca aaggcgcgcg tccacgccaa gacaaaggag 5100
gccacgtgcg aggggtagcg gtcgttgtcc accagggggt ccaccttttc caccgtgtgc 5160
agacacatgt ccccctcctc cgcatccaag aaggtgattg gcttgtaggt gtaggccacg 5220
tgaccggggg tccccgacgg gggggtataa aagggggcgg gtctgtgctc gtcctcactc 5280
tcttccgcgt cgctgtccac gagcgccagc tgttggggta ggtattccct ctcgagagcg 5340
ggcatgacct cggcactcag gttgtcagtt tctagaaacg aggaggattt gatgttggcc 5400
tgccctgccg caatgctttt taggagactt tcatccatct ggtcagaaaa gactattttt 5460
ttattgtcaa gcttggtggc aaaggagcca tagagggcgt tggagagaag cttggcgatg 5520
gatctcatgg tctgattttt gtcacggtcg gcgcgctcct tggccgcgat gttgagctgg 5580
acatactcgc gcgcgacaca cttccattct gggaagacgg tggtgcgctc gtcgggcacg 5640
atcctgacgc gccagccgcg attatgcagg gtgaccaggt ccacgctggt ggccacctcg 5700
ccgcgcaggg gctcgttggt ccagcagagg cgtccgccct tgcgcgagca gaacgggggc 5760
agcacatcaa gcagatgctc gtcagggggg tccgcatcga tggtgaagat gcccggacag 5820
agttccttgt caaaataatc gatttttgag gatgcatcat ccaaggccat ctgccactcg 5880
cgggcggcca gcgctcgctc gtaggggttg aggggcggac cccagggcat gggatgcgtg 5940
agggcggagg cgtacatgcc gcagatgtcg tagacataga tgggctccga gaggatgccg 6000
atgtaggtgg gataacagcg ccccccgcgg atgctggcgc gcacatagtc atacaactcg 6060
tgcgaggggg ccaagaaagc ggggccgaga ttggtgcgct ggggctgctc ggcgcggaag 6120
acgatctggc gaaagatggc atgcgagttg gaggagatgg tgggccgttg gaagatgtta 6180
aagtgggcgt ggggcaagcg gaccgagtcg cggatgaagt gcgcgtagga gtcttgcagc 6240
ttggcaacga gctcggcggt gacaaggacg tccatggcgc agtagtccag cgtttcacgg 6300
atgatgtcat aacccgcctc ttctttcttc tcccacagcg cgcggttgag ggcgtactcc 6360
tcgtcatcct tccagtactc ccggagcggg aatcctcgat cgtccgcacg gtaagagccc 6420
agcatgtaga aatggttcac ggccttgtag ggacagcagc ccttctccac ggggagggcg 6480
taagcttgag cggccttgcg gagcgaggtg tgcgtcaggg cgaaggtatc cctaaccatg 6540
actttcaaga actggtactt gaaatccgag tcgtcgcagc cgccgtgctc ccagagctcg 6600
aaatcggtgc gcttcttcga gagggggtta ggcagagcga aagtgacgtc attgaagaga 6660
atcttgcctg cccgcggcat gaaattgcgg gtgatgcgga aagggcccgg aacggaggct 6720
cggttgttga tgacctgggc ggcgaggacg atctcgtcga agccgttgat gttgtgcccg 6780
acgatgtaga gttccatgaa tcgcgggcgg cctttgatgt gcggcagctt tttgagttcc 6840
tcgtaggtga ggtcctcggg gcattgcagg ccgtgctgct cgagcgccca ctcctggaga 6900
tgtgggttgg cttgcatgaa tgaagcccag agctcgcggg ccatgagggt ctggagctcg 6960
tcgcgaaaga ggcggaactg ctggcccacg gccatctttt ctggggtgac gcagtagaag 7020
gtgagggggt cccgctccca gcgatcccag cgtaagcgca cggcgagatc gcgagcgagg 7080
gcgaccagct cggggtcccc ggagaatttc atgaccagca tgaaggggac gagctgcttg 7140
ccgaaggacc ccatccaggt gtaggtttct acatcgtagg tgacaaagag ccgctccgtg 7200
cgaggatgag agccgattgg gaagaactgg atttcctgcc accagttggt cgagtggctg 7260
ttgatgtgat gaaagtagaa atcccgccgg cgaaccgagc actcgtgctg atgcttgtaa 7320
aagcgtccgc agtactcgca gcgctgcacg ggctgtacct catccacgag atacacagcg 7380
cgtcccttga ggaggaactt caggagtggc ggccctggct ggtggttttc atgttcgcct 7440
gcgtgggact caccctgggg ctcctcgagg acggagaggc tgacgagccc gcgcgggagc 7500
caggtccaga tttcggcgcg gcgggggcgg agagcgaaaa cgagggcgcg cagttgggag 7560
ctgtccatgg tgtcgcggag atccaggtcc gggggcaggg ttctgaggtt gacctcgtag 7620
aggcgggtga gggcgtgctt gagatgcaga tggtacttga tctccacggg tgagttggtg 7680
gtcgtgtcca cgcattgcat gagcccgtag ctgcgcgggg ccacgaccgt gccgcggtgc 7740
gcttttagaa gcggtgtcgc ggacgcgctc ccggcggcag cggcggttcc ggccccgcgg 7800
gcagtggcgg tagaggcacg tcggcgtggc gctcgggcag gtcccggtgc tgcgccctga 7860
gagcgctggc gtgcgcgacg acgcggcggt tgacatcctg gatctgccgc ctttgcgtga 7920
agaccacggg ccccgtgact ttgaacctga aagacagttc aacagaatca atctcggcgt 7980
cattgacggc ggcctgacgc aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga 8040
tctcggacat gaactgctcg atttcctcct cctggagatc gccgcggccc gcgcgctcta 8100
cggtggcggc aaggtcattc gagatgcgac ccatgagctg cgagaaggcg cccaggccgc 8160
tctcgttcca gacgcggctg taaaccacgt ccccgtcggc gtcgcgcgcg cgcatgacca 8220
cctgcgcgag gttgagctcc acgtgccgcg taaagacggc gtagttgcgc aggcgctgga 8280
agaggtagtt gagggtggtg gcgatgtgct cggtgacgaa gaagtacata atccagcggc 8340
gcaggggcat ttcgctgatg tcgccaatgg cctccagcct ttccatggcc tcgtagaaat 8400
ccacggcgaa gttgaaaaac tgggcgttgc gggccgagac cgtgagctcg tcttccagga 8460
gcctgatgag ttcggcgatg gtggcgcgca cctcgcgctc gaaatcccag ggggcctcct 8520
cctcttcctc ttcttccatg acgacctctt cttctatttc ttcctctggg ggcggtggtg 8580
gtggcggggc ccgacgacga cggcgacgca ccgggagacg gtcgacgaag cgctcgatca 8640
tctccccgcg gcggcgacgc atggtttcgg tgacggcgcg accccgttcg cgaggacgca 8700
gcgtgaagac gccgccggtc atctcccggt aatggggtgg gtccccgttg ggcagcgata 8760
gggcgctgac aatgcatctt atcaattgcg gtgtagggca cgtgagcgcg tcgagatcga 8820
ccggatcgga gaatctttcg aggaaagcgt ctagccaatc gcagtcgcaa ggtaagctca 8880
aacacgtagc agccctgtgg acgctgttag aattgcggtt gctgatgatg taattgaagt 8940
aggcgttttt gaggcggcgg atggtggcga ggaggaccag gtccttgggt cccgcttgct 9000
ggatgcggag ccgctcggcc atgccccagg cctggccctg acaccggctc aggttcttgt 9060
agtagtcatg catgagcctc tcgatgtcat cactggcgga ggcggagtct tccatgcggg 9120
tgaccccgac gcccctgaac ggctgcacga gcgccaggtc ggcgacgacg cgctcggcga 9180
ggatggcctg ttgcacgcgg gtgagggtgt cctggaagtc gtccatgtcg acgaagcggt 9240
ggtaggcccc tgtgttgatg gtgtaagtgc agttggccat aagcgaccag ttgacggtct 9300
gcaggccggg ttgcacgacc tcggagtacc tgagccgcga gaaggcgcgc gagtcgaaga 9360
catagtcgtt gcaggtgcgc acgaggtact ggtatccgac tagaaagtgc ggcggcggct 9420
ggcggtagag cggccagcgc tgggtggccg gcgcgcccgg ggccaggtcc tcaagcatga 9480
gtcggtggta gccgtagagg tagcgggaca tccaggtgat gccggcggcg gtggtggagg 9540
cgcgcgggaa ctcgcggacg cggttccaga tgttgcgcag gggcaggaaa tagtccatgg 9600
tcggcacggt ctggccggtg agacgcgcgc agtcattgat gctctagagg caaaaacgaa 9660
agcggttgag cgggctcttc ctccgtagcc tggcggaacg caaacgggtt aggccgcgtg 9720
tgtaccccgg ttcgagtccc ctcgaatcag gctggagccg cgactaacgt ggtattggca 9780
ctcccgtctc gacccaagcc cgatagccgc caggatacgg cggagagccc tttttgtcgg 9840
ccgaggggag tcgctagact tgaaagcggc cgaaaaccct gccgggtagt ggctcgcgcc 9900
cgtagtctgg agaagcatcg ccagggttga gtcgcggcag aacccggttc aaggacggcc 9960
gcggcgagcg ggacttggtc accccgccga tttaaagacc cacagccagc cgacttctcc 10020
agttacggga gcgagccccc ttttttcttt ttgccagatg catcccgtcc tgcgccaaat 10080
gcgtcccacc cccccggcga ccaccgcgac cgcggccgta gcaggcgccg gcgctagcca 10140
gccacagcca cagacagaga tggacttgga agagggcgaa gggctggcga gactgggggc 10200
gccgtccccg gagcgacatc cccgcgtgca gctgcagaag gacgtgcgcc cggcgtacgt 10260
gcctgcgcag aacctgttca gggaccgcag cggggaggag cccgaggaga tgcgcgactg 10320
ccggtttcgg gcgggcaggg agctgcgcga gggcctggac cgccagcgcg tgctgcgcga 10380
cgaggatttc gagccgaacg agcagacggg gatcagcccc gcgcgcgcgc acgtggcggc 10440
ggccaacctg gtgacagcct acgagcagac ggtgaagcag gaacgcaact ttcaaaagag 10500
tttcaacaac cacgtgcgca ccctgatcgc gcgcgaggag gtggccctgg gcctgatgca 10560
cctgtgggac ctggcggagg ccattgtgca gaacccggac agcaagcctc tgacggcaca 10620
actgttcctg gtggtgcagc acagcaggga caacgaggcg ttcagggagg cgctgctaaa 10680
catcgccgag cccgagggcc gctggctgct ggagctgatc aacatcttgc aaagcatcgt 10740
agtgcaggag cgcagcctga gcttggccga gaaggtggcg gcgatcaact actcggtgct 10800
aagcctgggc aagttttacg cgcgcaagat ttacaagacg ccgtacgtgc ccatagacaa 10860
ggaggtgaaa atagacagct tttacatgcg catggcgctc aaggtgctga cgctgagcga 10920
cgacctgggc gtgtaccgca acgaccgcat ccacaaggcc gtgagcacga gccggcggcg 10980
cgagctgagc gaccgcgagc tgatgctaag cctgcgccgg gcgctggtag gtggcgccgc 11040
cggcggcgag gagtcctact tcgacatggg ggcggacctg cattggcagc cgagccggcg 11100
cgccttggag gccgcctacg gtccagagga cttggatgag gatgaggaag aggaggagga 11160
tgcacccgtt gcggggtact gacgcctccg tgatgtgttt ttagatgtcc cagcagcaag 11220
ccccggaccc cgccataagg gcggcgctgc aaagccagcc gtccggtcta gcatcggacg 11280
actgggaggc cgcgatgcaa cgcatcatgg ccctgacgac ccgcaacccc gagtccttta 11340
gacaacagcc gcaggccaac agactttcga ccattctgga ggcggtggtc ccctctcgga 11400
ccaaccccac gcacgagaag gtgctggcga tcgtgaacgc gctggcggag aacaaggcta 11460
ttcgtcccga cgaggctggg ctggtataca acgccctgct ggagcgcgtg ggccgctaca 11520
acagcacgaa cgtgcagtcc aacctggacc ggctggtgac ggacgtgcgc gaggccgtgg 11580
cgcagcgcga gcggttcaag aacgagggcc tgggctcgct ggtggcgctg aacgccttcc 11640
tggcgacgca gccggcgaac gtgccgcgcg ggcaggacga ttataccaac tttatcagcg 11700
cgctgcggct gatggtgacc gaggttcccc agagcgaggt gtaccagtcg ggcccggact 11760
actttttcca gactagcaga cagggcctgc agacggtgaa cctgagccag gctttcaaga 11820
acctgcgcgg gctgtggggc gtgcaggcgc ccgtgggcga ccggtcgacg gtgagcagct 11880
tgctgacgcc caactcgcgg ctgctgctgc tgctgatcgc gcccttcacc gacagcggca 11940
gcgtgaaccg caactcgtac ctgggtcacc tgctgacgct gtaccgcgag gccataggcc 12000
aggcacaggt ggacgagcag accttccagg agatcactag tgtaagccgc gcgctgggtc 12060
agaacgacac cgacagtctg agggccaccc tgaacttctt gctgaccaat agacagcaga 12120
agatcccggc gcagtatgcg ctgtcggccg aggaggagcg catcctgaga tatgtgcagc 12180
agagcgtagg gctgtttctg atgcaggagg gggccacccc cagcgccgcg ctggacatga 12240
ccgcgcgcaa catggaacct agcatgtacg ccgccaaccg gccgtttatc aataagctga 12300
tggactacct gcaccgcgcg gcgtccatga actcggacta ctttaccaat gccattttga 12360
acccgcactg gctcccgccg ccggggttct acacgggcga gtacgacatg cctgacccca 12420
acgacgggtt tttgtgggac gacgtggaca gcgcggtgtt ctcaccgacc ttgcaaaagc 12480
gccaggaggc ggtgcgcacg cccgcgagcg agggcgcggt gggtcggagc ccctttccta 12540
gcttagggag tttgcatagc ttgccgggct cggtgaacag cggcagggtg agccggccgc 12600
gcttgctggg cgaggacgag tacctaaacg actcgctgct gcagccgccg cgggtcaaga 12660
acgccatggc caataacggg atagagagtc tggtggacaa actgaaccgc tggaagacct 12720
acgctcagga ccatagggag cctgcgcccg cgccgcggcg acagcgccac gaccggcagc 12780
ggggcctggt gtgggacgac gaggactcgg ccgacgatag cagcgtgttg gacttgggcg 12840
ggagcggtgg ggtcaacccg ttcgcgcatc tgcagcccaa actggggcga cggatgtttt 12900
gaatgcaaaa taaaactcac caaggccata gcgtgcgttc tcttccttgt tagagatgag 12960
gcgtgcggtg gtgtcttcct ctcctcctcc ctcgtacgag agcgtgatgg cgcaggcgac 13020
cctggaggtt ccgtttgtgc ctccgcggta tatggctcct acggagggca gaaacagcat 13080
tcgttactca gagctggctc cgctgtacga caccactcgc gtgtacttgg tggacaacaa 13140
gtcggcggac atcgcttccc tgaactacca aaacgaccac agcaactttc tgaccacggt 13200
ggtgcaaaac aacgatttca cccccgccga ggctagcacg cagacgataa attttgacga 13260
gcggtcgcgg tggggcggtg atctgaagac cattctgcac accaacatgc ccaatgtgaa 13320
cgagtacatg tttaccagca agtttaaggc gcgggtgatg gtggctagga aacacccaca 13380
gggggtagaa gcaacagatt taagcaagga tatcttagag taccagtggt ttgagtttac 13440
cctgcccgag ggcaactttt ccgagaccat gaccatagac ctgatgaaca acgccatctt 13500
ggaaaactac ttgcaagtgg ggcggcaaaa tggcgtgctg gagagcgata tcggagtcaa 13560
gtttgacagc aggaatttca agctgggctg ggaccccgtg accaagctgg tgatgccagg 13620
ggtctacacc tatgaggcct tccacccgga cgtggtgctg ctgcctggct gcggggtgga 13680
cttcaccgag agccgcctaa gcaaccttct gggcattcgc aagaagcaac ctttccaaga 13740
gggcttcaga atcatgtatg aggatctcga agggggcaac attcccgcac ttctgaatgt 13800
gaccaagtac ctggaaagca agaagaagct agaggagaat gccgctaagg ctaatggtcc 13860
tgcaagagga gacagtagtg tctcaagaga ggtggaaaag gcagctgaaa aagagcttgt 13920
cattgagccc atcaagcaag atgatagcaa gagaagttac aacctcattg agggtaccca 13980
tgacaccctg taccgaagct ggtacctgtc ctatacctac ggggaccccg agaagggggt 14040
gcagtcgtgg acgctgctca ccaccccgga cggtcactgc ggcgcggagc aagtctactg 14100
gtcgctgccg gacctcatgc aagaccccgt caccttccgc tctacccagc aagtcagcaa 14160
ctaccccgtg gtcggcgccg agctcatgcc tttccgcgcc aagagctttt acaacgacct 14220
cgccgtctac tcccagctca tccgcagcta cacctccctc acccacgtct tcaaccgctt 14280
ccccgacaac cagatcctct gccgcccgcc cgcgcccacc atcaccaccg tcagtgaaaa 14340
cgtgcctgct ctcacagatc acgggacgct accgctgcgc agcagtatcc gcggagtcca 14400
gcgagtgacc gtcactgacg cccgtcgccg cacctgtccc tacgtctaca aggccctggg 14460
catagtcgcg ccgcgcgtgc tttccagtcg caccttctaa aaaatgtcta ttctcatctc 14520
gcccagcaat aacaccggct ggggtcttac taggcccagc accatgtacg gaggagccaa 14580
gaaacgctcc cagcagcacc ccgtccgcgt ccgcggccac tttcgcgctc cctggggcgc 14640
atacaagcgc gggcggactt ccaccgccgc cgccgtgcgc accaccgtcg acgacgtcat 14700
cgactcggtg gtcgccgatg cgcgcaacta tacccccgcc ccctccaccg tggacgcggt 14760
cattgacagc gtggtggccg acgcgcgcga ctatgccaga cgcaagagcc ggcggcgacg 14820
gatcgccagg cgccaccgga gcacgcccgc catgcgcgcc gcccgggctc tgctgcgccg 14880
cgccagacgc acgggccgcc gggccatgat gcgagccgcg cgccgcgctg ccactgcacc 14940
cacccccgca ggcaggactc gcagacgagc ggccgctgcc gccgccgcgg ccatctctag 15000
catgaccaga cccaggcgcg gaaacgtgta ctgggtgcgc gactccgtca cgggcgtgcg 15060
cgtgcccgtg cgcactcgtc ctcctcgtcc ctgatctaat gcttgtgtcc tcccccgcaa 15120
gcgacgatgt caaagcgcaa aatcaaggag gagatgctcc aggtcgtcgc cccggagatt 15180
tacggacccc cggaccagaa accccgcaaa atcaagcggg ttaaaaaaaa ggatgaggtg 15240
gacgaggggg cagtagagtt tgtgcgcgag ttcgctccgc ggcggcgcgt aaattggaag 15300
gggcgcaggg tgcagcgtgt gttgcggccc ggcacggcgg tggtgttcac gcccggcgag 15360
cggtcctcgg tcaggagcaa gcgtagctat gacgaggtgt acggcgacga cgacatcctg 15420
gaccaggcgg cggagcgggc gggcgagttc gcctacggga agcggtcgcg cgaagaggag 15480
ctgatctcgc tgccgctgga cgaaagcaac cccacgccga gcctgaagcc cgtgaccctg 15540
cagcaggtgc tgccccaggc ggtgctgctg ccgagccgcg gggttaagcg cgagggcgag 15600
agcatgtacc cgaccatgca gatcatggtg cccaagcgcc ggcgcgtgga ggacgtgctg 15660
gacaccgtga aaatggatgt ggagcccgag gtcaaggtgc gccccatcaa gcaggtggcg 15720
ccgggcctgg gcgtgcaaac cgtggacatt cagatcccca ccgacatgga tgtcgacaaa 15780
aaaccctcga ccagcatcga ggtgcaaacc gacccctggc tcccagcctc caccgctacc 15840
gccgccacgg ccaccgagcc tcccaggagg cgaagatggg gccctgccaa ccggctgatg 15900
cccaactacg tgttgcatcc ttccatcatc ccgacgccgg gctaccgcgg cacccggtac 15960
tacgccagcc gcaggcgccc agccagtaaa cgccgccgcc gcaccgccac ccgccgccgt 16020
ctggcccccg cccgcgtgcg ccgcgtgacc acgcgccggg gccgctcgct cgttctgccc 16080
accgtgcgct accaccccag catcctttaa tccgtgtgct gtgatactgt tgcagagaga 16140
tggctctcac ttgccgcctg cgcatccccg tcccgaatta ccgaggaaga tcccgccgca 16200
ggagaggcat ggcaggcagt ggcctgaacc gccgccggcg gcgggccatg cgcaggcgcc 16260
tgagtggcgg ctttctgccc gcgctcatcc ccataatcgc cgcggccatc ggcacgatcc 16320
cgggcatagc ttccgttgcg ctgcaggcgt cgcagcgccg ttgatgtgcg aataaagcct 16380
ctttagactc tgacacacct ggtcctgtat atttttagaa tggaagacat caattttgcg 16440
tccctggctc cgcggcacgg cacgcggccg ttcatgggca cctggaacga gatcggcacc 16500
agccagctga acgggggcgc cttcaattgg agcagtgtct ggagcgggct taaaaatttc 16560
ggctcgacgc tccggaccta tgggaacaag gcctggaata gtagcactgg gcagttgtta 16620
agggaaaagc tcaaagacca gaacttccag caaaaggtgg tggacgggct ggcctcgggc 16680
attaacgggg tggtggacat cgcgaaccca ggccgtgcag cgcgagataa acaaccgcct 16740
ggacccgcgg ccgcccacgg tggtggagat ggaagatgca actcctccgc cgcccaaggg 16800
cgagaagcga ccgcggcccg acgcggagga gacgatcctg caggtggacg agccgccctc 16860
gtacgaggag gccgtaaagg ccggcatgcc caccacgcgc atcatcgcgc cactggccac 16920
gggtgtaatg aaacccgcca cccttgacct gcctccacca cccacgcccg ctccaccgaa 16980
ggcagctccg gtagtgcagc cccctccggt ggcgaccgcc gtgcgccgcg tccccgcccg 17040
ccgccaggcc caaaactggc aaagcacgct gcacagtatt gtgggcctgg gagtgaaaag 17100
tctgaagcgc cgccgatgct attgaaagag aggaaggaag acactaaagg gagagcttaa 17160
cttgtatgtg ccttaccgcc agagaacgcg cgaagatggc caccccctcg atgatgccgc 17220
agtgggcgta catgcacatc gccgggcagg acgcctcgga gtacctgagc ccgggtctgg 17280
tgcagtttgc ccgcgccacc gacacgtact tcagcctggg caacaagttt aggaacccca 17340
cggtggcccc aacccacgat gtgaccacgg accggtccca gcgtctgacg ctgcgcttcg 17400
tgcccgtgga tcgcgaggac accacgtact cgtacaaggc gcgcttcact ctggccgtgg 17460
gcgacaaccg ggtgctagac atggccagca cttactttga catccgcggc gttctggacc 17520
gcggccccag cttcaaaccc tactcgggca cggcttacaa cagcctggcc cccaagggcg 17580
cccccaattc cagtcagtgg gatgctcaag aaaaaaatgg acaaggagga aatgacatgg 17640
ttaccaaaac tcacacattt ggcgtggctg ctatgggagg aacaaatatt acaaaccagg 17700
gtttgttaat tggaactgaa gaaacagccg ataatcctcc aaaggaaatc tttgcagaca 17760
aattattcca gccagaacct caagtaggag aggaaaactg gcaagacagc aatgcattct 17820
atggaggcag ggctcttaag aaggaaacta aaatgaaacc atgctatgga tcttatgcta 17880
gaccaacaaa cacaagtggc ggacaggcta agcttaaaac tggtgacaat atcgatccta 17940
ccaaggattt cgacatagat cttgctttct tcgatactcc tggcggaaat cctccagcag 18000
gtggtagtgg aacggaagaa tacaaagcag atattgttat gtacactgaa aatgtcaacc 18060
ttgaaacacc tgacactcat gtggtgtaca aaccagccaa agaggatgaa agttctcagg 18120
ccaacttggt tcagcagtcc atgcccaaca gacccaacta cattggcttc agagacaatt 18180
ttgtggggct catgtattac aacagcactg gcaacatggg agtgctggct ggtcaggcct 18240
ctcagttgaa tgctgtggtg gacttgcaag acagaaacac agagctgtct taccagctct 18300
tgctagattc tctgggtgac agaaccagat actttagcat gtggaactct gcggtggaca 18360
gctatgatcc agatgtcaga atcattgaaa atcacggtgt ggaagatgag cttccaaact 18420
attgctttcc attggatggc tctggtacca atgctgccta ccaaggtgta aaggttcaag 18480
atggtgaaga cggggataaa gaaactgaat gggaaaaaga taccaaagtc gcagatcgta 18540
accaactgtg caagggtaac atcttcgcca tggagatcaa cctccaggcc aacctgtgga 18600
agagttttct gtactcgaac gtggccctgt acctgcccga ctcctacaag tacacgccgg 18660
ccaacatcac gctgcccgcc aacaccaaca cctacgagta catgaacggc cgcgtggtag 18720
ccccctcgct ggtggacgca tacgtcaaca tcggtgcgcg ctggtcgctg gaccccatgg 18780
acaacgtcaa ccccttcaac caccaccgca acgcgggcct gcgctaccgc tccatgcttc 18840
tcggcaacgg ccgctacgtg cccttccaca tccaagtgcc ccaaaagttc tttgccatta 18900
agaacctgct cctgctcccc ggctcctaca cctacgagtg gaacttccgc aaggatgtca 18960
acatgatcct gcagagttcc ctcggaaacg acctgcgcgt cgacggcgcc tccgtgcgct 19020
tcgacagcgt caacctctac gctaccttct tccccatggc gcacaacacc gcctccaccc 19080
tggaagccat gctgcgcaac gacaccaacg accagtcctt taacgactac ctctcggccg 19140
ccaacatgct ctaccccata ccggccaagg ccaccaacgt gcccatctcc atcccctcgc 19200
gcaactgggc tgccttccgc ggctggagtt tcacccggct caagaccaag gaaactcctt 19260
cccttggctc gggtttcgac ccctactttg tctactcggg ctccatcccc tacctcgacg 19320
ggaccttcta cctcaaccac accttcaaaa aggtgtccat tatgttcgac tcctcggtca 19380
gctggcccgg caacgaccgg ctgctcacgc cgaatgagtt cgagatcaag cgcagcgtcg 19440
acggggaggg ctacaacgtg gcccaatgca acataaccaa ggactggttc ctcgtccaga 19500
tgctctccca ctacaacatc ggctaccagg gcttccacgt gcccgagggc tacaaggacc 19560
gcatgtactc ctttttccgc aacttccagc ccatgagcag gcaggtggtg gatgagatca 19620
actacaagga ctacaaggcc gtcaccctgc ccttccagca caacaactct ggcttcaccg 19680
gctacctcgc acccaccatg cgtcaggggc agccttaccc cgccaacttc ccttacccgc 19740
tcatcggctc caccgcagtc ccctccgtca cccagaaaaa gttcctctgc gacagggtca 19800
tgtggcgcat ccccttctcc agcaacttca tgtccatggg tgccctcacc gacctgggtc 19860
agaacatgct ctatgccaac tcggcccacg cgctcgacat gaccttcgag gtggacccca 19920
tggatgagcc caccctcctc tatcttctct tcgaagtttt cgacgtggtc agagtgcacc 19980
agccgcaccg cggcgtcatc gaggccgtct acctgcgcac acccttctcc gccggcaacg 20040
ccaccaccta agcatgagcg gttccagcga acgagaactc gcggccatcg tgcgcgacct 20100
gggctgcggg ccctactttt tgggcaccca cgacaagcgc ttcccgggct tcctagccgg 20160
cgacaagctg gcctgcgcca tcgtcaacac ggccggccgc gagaccggag gcgtgcactg 20220
gctcgccttc ggctggaacc cgcgctcgcg cacctgctac atgttcgacc cctttgggtt 20280
ctcggaccgc cggctcaagc agatttacag cttcgagtac gaggccatgc tgcgccgaag 20340
cgccctggcc tcctcgcccg accgctgtct cagcctcgaa cagtccaccc agaccgtgca 20400
ggggcccgac tccgccgcct gcggactttt ttgttgcatg ttcttgcatg cgttcgtgca 20460
ctggcccgac cgacccatgg acggaaaccc caccatgaac ttgctgacgg gggtgcccaa 20520
cggcatgcta caatcgccac aggtgctgcc caccctccgg cgcaaccagg aggagctcta 20580
ccgcttcctc gcgcgccact ccccttactt ccgatcccac cgcgccgcca tcgaacacgc 20640
caccgctttt gacaaaatga aacaactgcg tgtatctcaa taaacagcac tttttatttt 20700
acatgcactg gagtatatgc aagttattta aaagtcgaag gggttctcgc gctcgtcgtt 20760
gtgcgccgcg ctggggaggg ccacgttgcg gtactggtac ttggaaagcc acttgaactc 20820
ggggatcacc agtttgggca ctggggtctc ggggaaggtc tcgctccaca tgcgccggct 20880
catctgcagg gcgcccagca tgtcagggcc ggagatcttg aaatcacagt tggggccggt 20940
gctctgcgcg cgcgagttgc ggtacacggg gttgcagcac tggaacacca tcagactggg 21000
gtacttcaca ctggcaagca cgctcttgtc gctaatctga tccttgtcca ggtcctcggc 21060
gttgctcagg ccgaacgggg tcatcttgca cagctggcgg cccaggaagg gcacgctctg 21120
aggcttgtgg ttacactcgc agtgcacggg catcagcatc atccccgcgc cgcgctgcat 21180
attcgggtag agggccttga cgaaggccgc gatctgcttg aaagcttgct gggccttggc 21240
cccctcgctg aagaacagac cgcagctctt cccgctgaac tggttattcc cgcacccggc 21300
atcatgcacg cagcagcgcg cgtcatggct ggtcagttgc accacgctcc gtccccagcg 21360
gttctgggtc accttagcct tgctgggctg ctccttcagc gcgcgctgtc cgttctcgct 21420
ggtcacatcc atctccacca cgtggtcctt gtgaatcatc accgttccat gcagacactt 21480
gagctgacct tccacctcgg tgcagccgtg atcccacagg acgcagccgg tgcactccca 21540
attcttgtgc gcgatcccgc tgtggctgaa aatgtaacct tgcaacaggc gacccataat 21600
ggtgctaaat gatttctggg tggtgaatgt cagttgcatc ccgcgggcct cctcgttcat 21660
ccaggtctgg cacatcttct ggaagatctc ggtctgctcc ggcatgagct tgtaagcatc 21720
gcgcaagccg ctgtcgacgc ggtagcgttc catcagcacg ttcatggtat ccatgccctt 21780
ctcccatgac gagaccagag gcagactcag ggggttgcgc acgttcagga caccaggggt 21840
cgcgggctcg acgatgcgtt ttccgtcctt gccttccttc aacagaaccg gaggctggct 21900
gaatcccact cccacgatca cggcgtcttc ctggggcatc tcttcgtcgg ggtctacctt 21960
ggtcacatgc ttggtctttc tggcttgctt cttttttgga gggctgtcca cggggaccac 22020
gtcctcctcg gaagacccgg agcccacccg ctgatacttt cggcgcttgg tgggcagagg 22080
aggtggcggc ggcgaggggc tcctctcctg ctccggcgga tagcgcgccg acccgtggcc 22140
ccggggcgga gtggcctctc gctccatgaa ccggcgcacg tcctgactgc cgccggccat 22200
tgtttcctag gggaagatgg aggagcagcc gcgtaagcag gagcaggagg aggacttaac 22260
cacccacgag caacccaaaa tcgagcagga cctgggcttc gaagagccgg ctcgtctaaa 22320
acccccacag gatgaacagg agcacgagca agacgcaggc caggaggaga ccgacgctgg 22380
gctcgagcat ggctacctgg gaggagagga ggatgtgctg ctaaaacacc tgcagcgcca 22440
gtccctcatc ctccgggacg ccctggccga ccggagcgaa acccccctca gcgtcgagga 22500
gctgtgtcgg gcctacgagc tcaacctctt ctcgccgcgc gtgcccccca aacgccagcc 22560
caacggcacc tgcgagccca acccgcgtct caacttctat cccgtctttg cggtccccga 22620
ggcccttgcc acctatcaca tctttttcaa gaaccaaaag atccccatct cctgtcgcgc 22680
caatcgcact cgcgccgacg cgctcctcgc tctggggccc ggcgcgcgca tacctgatat 22740
cgcttccctg gaagaggtgc ccaagatctt cgaagggctc ggtcgggacg agacgcgcgc 22800
ggcaaacgct ctgaaagaaa cagcagagga agagggttac actagcgccc tggtagagtt 22860
ggaaggcgac aacgccaggc tggccgtgct taagcgcagc gtcgagctca cccatttcgc 22920
ctaccccgcc gtcaacctcc cgcccaaggt catgcgtcgc atcatggatc agctcatcat 22980
gccccacatc gaggcccttg atgaaagtca ggaacagcgc cccgagaacg cccagcccgt 23040
ggtcagcgac gagatgctcg cgcgctggct cgggacccgc gacccccagg ccctggagca 23100
gcggcgcaag ctcatgctgg ccgtggtcct ggtcaccctt gagctcgaat gcatgcgccg 23160
cttttttacc gaccccgaga ccctgcgcaa ggtcgaggag accctgcact acactttcag 23220
acacggtttc gtcaggcagg cctgcaagat ctccaacgtg gagctgacca acctggtctc 23280
ctgcctgggg atcctacacg agaaccgctt gggacagacc gtgctccact ctaccctgaa 23340
gggcgaggcg cggcgggact acatccgcga ctgcgtcttt ctctttctct gccacacatg 23400
gcaagcggcc atgggcgtgt ggcagcagtg tctcgaggac gagaacctga aggagctgga 23460
caagcttctt gctagaaacc ttaaaaagct gtggacgggc ttcgacgagc gcaccgtcgc 23520
ctcggacctg gccgagatcg tcttccccga gcgcctgagg cagacgctga aaggagggct 23580
gcccgacttc atgagccaga gcatgttgca aaactaccgc actttcattc tcgagcgatc 23640
tgggatgctg cccgccacct gcaacgcctt cccctccgac tttgtcccgc tgagctaccg 23700
cgagtgtccc ccgccgctgt ggagccactg ctacctcttg cagctggcca actacattgc 23760
ccaccactcg gatgtgatcg aggacgtgag cggcgagggg ctgctcgagt gccactgtcg 23820
ctgcaaccta tgctccccgc accgctccct ggtctgcaac ccccagctac tgagcgagac 23880
ccaggtcatc ggtacctttg agctgcaagg tccgcaggag tccaccgctc cgctgaaact 23940
cacgccgggg ttgtggactt ccgcgtacct gcgcaaattt gtacccgagg actactacgc 24000
ccatgagata aagttcttcg aggaccaatc gcgtccgcag cacgcggatc tcacggcctg 24060
cgtcatcacc cagggcgcga tcctcgccca attgcacgcc atccaaaaat cccgccaaga 24120
gtttcttctg aaaaagggta gaggggtcta cctggacccc cagacgggcg aggtgctcaa 24180
cccgggtctc ccccagcatg ccgaggaaga agcaggagcc gctagtggag gagatggaag 24240
aagaatggga cagccaggca gaggaggacg aatgggagga ggagacagag gaggaagact 24300
tggaagaggt ggaagaggag caggcaacag agcagcccgt cgccgcacca tccgcgccgg 24360
cagcccctcc ggtcacggat acaacctccg cagctccggc caagcctcct cgtagatggg 24420
atcgagtgaa gggtgacggt aagcacgagc gacagggcta ccgatcatgg agggcccaca 24480
aagccgcgat catcgcctgc ttgcaagact gcggggggaa catcgctttc gcccgccgct 24540
acctgctctt ccaccgcggg gtgaacatcc cccgcaacgt gttgcattac taccgtcacc 24600
ttcacagcta agaaaaagca agtcaaagga gtcgccggag gaggaggcct gaggatcgcg 24660
gcgaacgagc ccttgaccac cagggagctg aggaaccgga tcttccccac tctttatgcc 24720
atttttcagc aaagtcgagg tcagcagcaa gagctcaaag taaaaaaccg gtctctgcgc 24780
tcgctcaccc gcagttgctt gtaccacaaa aacgaagatc agctgcagcg cactctcgaa 24840
gacgccgagg ctctgttcca caagtactgc gcgctgactc ttaaagacta aggcgcgccc 24900
acccggaaaa aaggcgggaa ttacctcatc gccaccatga gcaaggagat tcccacccct 24960
tacatgtgga gctatcagcc ccagatgggc ctggccgcgg gcgcctccca ggactactcc 25020
acccgcatga actggcttag tgccggcccc tcgatgatct cacgggtcaa cggggtccgt 25080
aaccatcgaa accagatatt gttgcagcag gcggcggtca cctccacgcc cagggcaaag 25140
ctcaacccgc gtaattggcc ctccaccctg gtgtatcagg aaatccccgg gccgactacc 25200
gtactacttc cgcgtgacgc actggccgaa gtccgcatga ctaactcagg tgtccagctg 25260
gccggcggcg cttcccggtg cccgctccgc ccacaatcgg gtataaaaac cctggtgatc 25320
cgaggcagag gcacacagct caacgacgag ttggtgagct cttacaatcg tctgcgaccg 25380
gacggagtgt tccaactagc cggagccggg agatcgtcct tcactcccaa ccaggcctac 25440
ctgaccttgc agagcagctc ttcggagcct cgctcgggag gcatcggaac ccaccagttc 25500
gtggaggagt ttgtgccctc ggtctacttc aaccccttct cgggctcgcc aggcctctac 25560
ccggacgagt ttataccgaa cttcgacgca gtgagagaag cggtggacgg ctacgactga 25620
agcttgttga ttaaaagccc agaaaccaat cagacccttc ctcatttccc catcccaata 25680
ctcataagaa taaatcattg gaattaatca ttcaataaag atcacttact tgaaatctga 25740
aagtatgtct ctggtgtagt tgctcagcaa cacctcggta ccctcctccc agctctggta 25800
ctccagtccc cggcgggcgg cgaacttcct ccacaccttg aaagggatgt caaagaggct 25860
ccgggtggaa gatgacttca accccgtcta cccctatggc tacgcgcgga atcagaatat 25920
ccccttcctc actcccccct ttgtctcctc cgatggattc aaaaacttcc cccctggggt 25980
actgtcactc aaactggctg atccaatcac cattaccaat ggggatgtat ccctcaaggt 26040
gggaggtggt ctcactttgc aagatggaag cctaactgta aaccctaagg ctccactgca 26100
agttaatact gataaaaaac ttgagcttgc atatgataat ccatttgaaa gtagtgctaa 26160
taaacttagt ttaaaagtag gacatggatt aaaagtatta gatgaaaaaa gtgctgcggg 26220
gttaaaagat ttaattggca aacttgtggt tttaacagga aaaggaatag gcactgaaaa 26280
tttagaaaat acagatggta gcagcagagg aattggtata aatgtaagag caagagaagg 26340
gttgacattt gacaatgatg gatacttggt agcatggaac ccaaagtatg acacgcgcac 26400
actttggaca acaccagaca catctccaaa ctgcacaatt gctcaagata aggactctaa 26460
actcactttg gtacttacaa agtgtggaag tcaaatatta gctaatgtgt ctttgattgt 26520
ggtcgcagga aagtaccaca tcataaataa taagacaaat ccaaaaataa aaagttttac 26580
tattaaactg ctatttaata agaacggagt gcttttagac aactcaaatc ttggaaaagc 26640
ttattggaac tttagaagtg gaaattccaa tgtttcgaca gcttatgaaa aagcaattgg 26700
ttttatgcct aatttggtag cgtatccaaa acccagtaat tctaaaaaat atgcaagaga 26760
catagtttat ggaactatat atcttggtgg aaaacctgat cagccagcag tcattaaaac 26820
tacctttaac caagaaactg gatgtgaata ctctatcaca tttaacttta gttggtccaa 26880
aacctatgaa aatgttgaat ttgaaaccac ctcttttacc ttctcctata ttgcccaaga 26940
atgaaagacc aataaacgtg tttttcattt gaaattttca tgtatcttta ttgattttta 27000
caccagcacg agtagacagt ctcccaccac cagcccattt tacagtgtac acggttctct 27060
cagcacgggt agccttaaat agggaaatat tctcattagt gcgggaattg gacttggggt 27120
ctataatcca cacagtttcc tggcgagcca aacgggggtc ggtgattgaa ataaagccgt 27180
cctctgaaaa gtcatccaag cgggcctcac agtccaaggt cacagtctgg tggaacgaga 27240
agaacgcaca gattcatact cggaaaacag gatgggtctg tgcctctcca tcagcgccct 27300
cagcagtctc tgccgccggg gctcggtgcg gctgctgcaa atgggatcgg gatcacaagt 27360
ctctctgact atgatcccaa cagccttcag catcagtctc ctggtgcgac gggcacagca 27420
ccgcatcctg atctctgcca tgttctcaca gtaagtgcag cacataatca ccatgttatt 27480
cagcagccca taattcaggg cgctccagcc aaagctcatg ttgggaatga tggaacccac 27540
gtgaccatcg taccagatgc gacagtatat cagatgcctg cccctcatga acacactgcc 27600
catgtacatg atctctttgg gcatgtttct gtttacaatc tggcggtacc aggggaagcg 27660
ctggttgaac atgcacccgt aaatgactct cctgaaccac acggccagca gggtgcctcc 27720
cgcccgacac tgcagggagc caggggatga acagtggcaa tgcaggatcc agcgctcgta 27780
cccgctcacc atttgagctc ttaccaagtc cagggtagcg gggcacaggc acactgacat 27840
acatcttttt aaaattttta tttcctctgt ggtgaggatc atatcccagg ggactggaaa 27900
ctcttggagc agggtaaagc cagcagcaca tggtaatcca cggacagaac ttacattatg 27960
ataatctgca tgatcacaat cgggcaacag gggatgttgt tcagtcagtg aagccctggt 28020
ttcctcatca gatcgtggta aacgggccct gcgatatgga tgatggcgga gcgagctgga 28080
ttgaatctcg gtttgcattg tagtggattc tcttgcgtac cttgtcgtac ttctgccagc 28140
agaaatgggc ccttgaacag catatacccc tcctacggcc gtcctttcgc tgctgccgct 28200
cagtcatcca actaaagtac atccattctc gaagattctg gagaagttcc tctgcatctg 28260
ataaaataaa aaacccgtcc atgcgaattc ccctcatcac atcagccagg actctgtagg 28320
ccatccccat ccagttaatg ctgccttgtc tatcattcag agggggcggt ggcaggactg 28380
gaagaaccat ttttattcca aacggtctcg aaggacgata aagtgcaagt cacgcaggtg 28440
acagcgttcc cctccgctgt gctggtggaa acagacagcc aggtcaaaac ccactctatt 28500
ttcaaggtgc tcgaccgtgg cttcgagcag tggctctacg cgcacatcca gcataagaat 28560
cacattaaag gctggccctc catcgatttc atcaatcatc aggttacatt cctgcaccat 28620
ccccaggtaa ttctcatttt tccagccttg gattatctct acaaattgtt ggtgtaagtc 28680
cactccgcac atgtggaaaa gctcccacag tgccccctcc actttcataa tcaggcagac 28740
cttcataata gaaacagatc ctgctgctcc accacctgca gcgtgttcaa aacaacaaga 28800
ttcaataagg ttctgccctc cgccctgagc tcgcgcctca atgtcagctg caaaaagtca 28860
cttaagtcct gggccactac agctgacaat tcagagccag ggctaagcgt gggactggca 28920
agcgtaaggg aaaactttaa tgctccaaag ctagcaccca aaaactgcat gctggaataa 28980
gctctctttg tgtctccggt gatgccttcc aaaatgtgag tgataaagcg tggtagtttt 29040
tctttaatca tttgcgtaat agaaaagtcc tctaaataag tcactaggac cccagggacc 29100
acaatgtggt agcttacacc gcgtcgctga agcatggtta gtagagatga gagtctgaaa 29160
aacagaaagc atgcactaaa ctaaggtggc tattttcact gaaggaaaaa tcactctctc 29220
cagcagcagg gtacccactg ggtggccctt gcggacatac aaaaatcggt ccgtgtgatt 29280
aaaaagcagc acagtaagtt cctgtcttct tccggcaaaa atcacatcag actgggttag 29340
tatgtccctg gcatggtagt cattcaaggc cataaatctg ccctgatatc cagtaggaac 29400
cagcacactc acttttaggt gaagcaatac caccccatgc ggaggaatgt ggaaagattc 29460
agggcaaaaa aattatatct attgctagcc ccttcctgga cgggagcaat ccctccagga 29520
ctatctataa aagcatacag agattcagcc atagcttagc ccgcttacca gtagacagaa 29580
agcacagcag tacaagcgcc aacagcagca actgactacc cactgaccca gctccctatt 29640
taaaggcacc ttacactgac gtaatgacca aaggtctaaa aaccccgcca aaaaaaacac 29700
acacgccctg ggtgtttttc acaaaaacac ttccgcgttc tcacttcctc gtatcgattt 29760
tgtgactcaa cttccgggtt cccacgttac gtcacttctg cccttacatg taacttggcc 29820
gtatggcgcc atcttgccca cgtccaaaat ggctttcatg accggccacg cctccgcgcc 29880
ggccgttagc cgtgcgtcgt gacgttattt gcatcaccgc ttctcgtcca atcagcgttg 29940
gctccgcccc aaaaccgtta aaattcaaaa gctcatttgc atattaactt ttgtttactt 30000
tgtggggtat attattagat agcctccggg gtccactgca attataactt taaataatgc 30060
caattattta aagttaatcc gcggagaacg cgtgccgcgg aacccctatt tgtttatttt 30120
tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat 30180
aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt 30240
ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg 30300
ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga 30360
tccttgagag ttttcgcccc gaagaacgtt tcccaatgat gagcactttt aaagttctgc 30420
tatgtggcgc ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac 30480
actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg 30540
gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca 30600
acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg 30660
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 30720
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 30780
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 30840
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 30900
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 30960
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 31020
agatcgctga gataggtgcc tcactgatta agcattggta aacgcgttta attaagttaa 31080
ttaaggatgc atgtttaaac tcgacagcga cacacttgca tcggatgcag cccggttaac 31140
gtgccggcac ggcctgggta accaggtatt ttgtccacat aaccgtgcgc aaaatgttgt 31200
ggataagcag gacacagcag caatccacag caggcataca accgcacacc gaggttactc 31260
cgttctacag gttacgacga catgtcaata cttgcccttg acaggcattg atggaatcgt 31320
agtctcacgc tgatagtctg atcgacaata caagtgggac cgtggtccca gaccgataat 31380
cagaccgaca acacgagtgg gatcgtggtc ccagactaat aatcagaccg acgatacgag 31440
tgggaccgtg gtcccagact aataatcaga ccgacgatac gagtgggacc gtggttccag 31500
actaataatc agaccgacga tacgagtggg accgtggtcc cagactaata atcagaccga 31560
cgatacgagt gggaccatgg tcccagacta ataatcagac cgacgatacg agtgggaccg 31620
tggtcccagt ctgattatca gaccgacgat acgagtggga ccgtggtccc agactaataa 31680
tcagaccgac gatacgagtg ggaccgtggt cccagactaa taatcagacc gacgatacga 31740
gtgggaccgt ggtcccagtc tgattatcag accgacgata caagtggaac agtgggccca 31800
gagagaatat tcaggccagt tatgctttct ggcctgtaac aaaggacatt aagtaaagac 31860
agataaacgt agactaaaac gtggtcgcat cagggtgctg gcttttcaag ttccttaaga 31920
atggcctcaa ttttctctat acactcagtt ggaacacgag acctgtccag gttaagcacc 31980
attttatcgc ccttatacaa tactgtcgct ccaggagcaa actgatgtcg tgagcttaaa 32040
ctagttcttg atgcagatga cgttttaagc acagaagtta aaagagtgat aacttcttca 32100
gcttcaaata tcaccccagc ttttttctgc tcatgaaggt tagatgcctg ctgcttaagt 32160
aattcctctt tatctgtaaa ggctttttga agtgcatcac ctgaccgggc agatagttca 32220
ccggggtgag aaaaaagagc aacaactgat ttaggcaatt tggcggtgtt gatacagcgg 32280
gtaataatct tacgtgaaat attttccgca tcagccagcg cagaaatatt tccagcaaat 32340
tcattctgca atcggcttgc ataacgctga ccacgttcat aagcacttgt tgggcgataa 32400
tcgttaccca atctggataa tgcagccatc tgctcatcat ccagctcgcc aaccagaaca 32460
cgataatcac tttcggtaag tgcagcagct ttacgacggc gactcccatc ggcaatttct 32520
atgacaccag atactcttcg accgaacgcc ggtgtctgtt gaccagtcag tagaaaagaa 32580
gggatgagat catccagtgc gtcctcagta agcagctcct ggtcacgttc attacctgac 32640
catacccgag aggtcttctc aacactatca ccccggagca cttcaagagt aaacttcaca 32700
tcccgaccac atacaggcaa agtaatggca ttaccgcgag ccattactcc tacgcgcgca 32760
attaacgaat ccaccatcgg ggcagctggt gtcgataacg aagtatcttc aaccggttga 32820
gtattgagcg tatgttttgg aataacaggc gcacgcttca ttatctaatc tcccagcgtg 32880
gtttaatcag acgatcgaaa atttcattgc agacaggttc ccaaatagaa agagcatttc 32940
tccaggcacc agttgaagag cgttgatcaa tggcctgttc aaaaacagtt ctcatccgga 33000
tctgaccttt accaacttca tccgtttcac gtacaacatt ttttagaacc atgcttcccc 33060
aggcatcccg aatttgctcc tccatccacg gggactgaga gccattacta ttgctgtatt 33120
tggtaagcaa aatacgtaca tcaggctcga accctttaag atcaacgttc ttgagcagat 33180
cacgaagcat atcgaaaaac tgcagtgcgg aggtgtagtc aaacaactca gcaggcgtgg 33240
gaacaatcag cacatcagca gcacatacga cattaatcgt gccgataccc aggttaggcg 33300
cgctgtcaat aactatgaca tcatagtcat gagcaacagt ttcaatggcc agtcggagca 33360
tcaggtgtgg atcggtgggc agtttacctt catcaaattt gcccattaac tcagtttcaa 33420
tacggtgcag agccagacag gaaggaataa tgtcaagccc cggccagcaa gtgggcttta 33480
ttgcataagt gacatcgtcc ttttccccaa gatagaaagg caggagagtg tcttctgcat 33540
gaatatgaag atctggtacc catccgtgat acattgaggc tgttccctgg gggtcgttac 33600
cttccacgag caaaacacgt agccccttca gagccagatc ctgagcaaga tgaacagaaa 33660
ctgaggtttt gtaaacgcca cctttatggg cagcaacccc gatcaccggt ggaaatacgt 33720
cttcagcacg tcgcaatcgc gtaccaaaca catcacgcat atgattaatt tgttcaattg 33780
tataaccaac acgttgctca acccgtcctc gaatttccat atccgggtgc ggtagtcgcc 33840
ctgctttctc ggcatctctg atagcctgag aagaaacccc aactaaatcc gctgcttcac 33900
ctattctcca gcgccgggtt attttcctcg cttccgggct gtcatcatta aactgtgcaa 33960
tggcgatagc cttcgtcatt tcatgaccag cgtttatgca ctggttaagt gtttccatga 34020
gtttcattct gaacatcctt taatcattgc tttgcgtttt tttattaaat cttgcaattt 34080
actgcaaagc aacaacaaaa tcgcaaagtc atcaaaaaac cgcaaagttg tttaaaataa 34140
gagcaacact acaaaaggag ataagaagag cacatacctc agtcacttat tatcactagc 34200
gctcgccgca gccgtgtaac cgagcatagc gagcgaactg gcgaggaagc aaagaagaac 34260
tgttctgtca gatagctctt acgctcagcg caagaagaaa tatccaccgt gggaaaaact 34320
ccaggtagag gtacacacgc ggatagccaa ttcagagtaa taaactgtga taatcaaccc 34380
tcatcaatga tgacgaacta acccccgata tcaggtcaca tgacgaaggg aaagagaagg 34440
aaatcaactg tgacaaactg ccctcaaatt tggcttcctt aaaaattaca gttcaaaaag 34500
tatgagaaaa tccatgcagg ctgaaggaaa cagcaaaact gtgacaaatt accctcagta 34560
ggtcagaaca aatgtgacga accaccctca aatctgtgac agataaccct cagactatcc 34620
tgtcgtcatg gaagtgatat cgcggaagga aaatacgata tgagtcgtct ggcggccttt 34680
ctttttctca atgtatgaga ggcgcattgg agttctgctg ttgatctcat taacacagac 34740
ctgcaggaag cggcggcgga agtcaggcat acgctggtaa ctttgaggca gctggtaacg 34800
ctctatgatc cagtcgattt tcagagagac gatgcctgag ccatccggct tacgatactg 34860
acacagggat tcgtataaac gcatggcata cggattggtg atttcttttg tttcactaag 34920
ccgaaactgc gtaaaccggt tctgtaaccc gataaagaag ggaatgagat atgggttgat 34980
atgtacactg taaagccctc tggatggact gtgcgcacgt ttgataaacc aaggaaaaga 35040
ttcatagcct ttttcatcgc cggcatcctc ttcagggcga taaaaaacca cttccttccc 35100
cgcgaaactc ttcaatgcct gccgtatatc cttactggct tccgcagagg tcaatccgaa 35160
tatttcagca tatttagcaa catggatctc gcagataccg tcatgttcct gtagggtgcc 35220
atcagatttt ctgatctggt caacgaacag atacagcata cgtttttgat cccgggagag 35280
actatatgcc gcctcagtga ggtcgtttga ctggacgatt cgcgggctat ttttacgttt 35340
cttgtgattg ataaccgctg tttccgccat gacagatcca tgtgaagtgt gacaagtttt 35400
tagattgtca cactaaataa aaaagagtca ataagcaggg ataactttgt gaaaaaacag 35460
cttcttctga gggcaatttg tcacagggtt aagggcaatt tgtcacagac aggactgtca 35520
tttgagggtg atttgtcaca ctgaaagggc aatttgtcac aacaccttct ctagaaccag 35580
catggataaa ggcctacaag gcgctctaaa aaagaagatc taaaaactat aaaaaaaata 35640
attataaaaa tatccccgtg gataagtgga taaccccaag ggaagttttt tcaggcatcg 35700
tgtgtaagca gaatatataa gtgctgttcc ctggtgcttc ctcgctcact cgagggcttc 35760
gccgtcgctc gactgcggcg agcctactgg ctgtaaaagg acagaccaca tcatggttct 35820
gtgttcatta ggttgttctg tccattgctg acataatccg ctccacttca acgtaacacc 35880
gcacgaagat ttctattgtt cctgaaggca tattcaaatc gttttcgtta ccgcttgcag 35940
gcatcatgac agaacactac ttcctataaa cgctacacag gctcctgaga ttaataatgc 36000
ggatctctac gataatggga gattttcccg actgtttcgt tcgcttctca gtggataaca 36060
gccagcttct ctgtttaaca gacaaaaaca gcatatccac tcagttccac atttccatat 36120
aaaggccaag gcatttattc tcaggataat tgtttcagca tcgcaaccgc atcagactcc 36180
ggcatcgcaa actgcacccg gtgccgggca gccacatcca gcgcaaaaac cttcgtgtag 36240
acttccgttg aactgatgga cttatgtccc atcaggcttt gcagaacttt cagcggtata 36300
ccggcataca gcatgtgcat cgcataggaa tggcggaacg tatgtggtgt gaccggaaca 36360
gagaacgtca caccgtcagc agcagcggcg gcaaccgcct ccccaatcca ggtcctgacc 36420
gttctgtccg tcacttccca gatccgcgct ttctctgtcc ttcctgtgcg acggttacgc 36480
cgctccatga gcttatcgcg aataaatacc tgtgacggaa gatcacttcg cagaataaat 36540
aaatcctggt gtccctgttg ataccgggaa gccctgggcc aacttttggc gaaaatgaga 36600
cgttgatcgg cacgtaagag gttccaactt tcaccataat gaaataagat cactaccggg 36660
cgtatttttt gagttatcga gattttcagg agctaaggaa gctaaaatgg agaaaaaaat 36720
cactggatat accaccgttg atatatccca atggcatcgt aaagaacatt ttgaggcatt 36780
tcagtcagtt gctcaatgta cctataacca gaccgttcag ctggatatta cggccttttt 36840
aaagaccgta aagaaaaata agcacaagtt ttatccggcc tttattcaca ttcttgcccg 36900
cctgatgaat gctcatccgg aattccgtat ggcaatgaaa gacggtgagc tggtgatatg 36960
ggatagtgtt cacccttgtt acaccgtttt ccatgagcaa actgaaacgt tttcatcgct 37020
ctggagtgaa taccacgacg atttccggca gtttctacac atatattcgc aagatgtggc 37080
gtgttacggt gaaaacctgg cctatttccc taaagggttt attgagaata tgtttttcgt 37140
ctcagccaat ccctgggtga gtttcaccag ttttgattta aacgtggcca atatggacaa 37200
cttcttcgcc cccgttttca ccatgggcaa atattatacg caaggcgaca aggtgctgat 37260
gccgctggcg attcaggttc atcatgccgt ctgtgatggc ttccatgtcg gcagaatgct 37320
taatgaatta caacagtact gcgatgagtg gcagggcggg gcgtaatttt tttaaggcag 37380
ttattggtgc ccttaaacgc ctggttgcta cgcctgaata agtgataata agcggatgaa 37440
tggcagaaat tcgatgataa gctgtcaaac atgagaatgg gtcgagaaca ggttgaactg 37500
ctgatcttca gatcctctac gccggacgca tcgtggccgg atccgattta ttcaacaaag 37560
ccacgttgtg tctcaaaatc tctgatgtta cattgcacaa gataaaaata tatcatcatg 37620
aacaataaaa ctgtctgctt acataaacag taatacaagg ggtgttatga gccatattca 37680
acgggaaacg tcttgctcga ggccgcgatt aaattccaac atggatgctg atttatatgg 37740
gtataaatgg gctcgcgata atgtcgggca atcaggtgcg acaatctatc gattgtatgg 37800
gaagcccgat gcgccagagt tgtttctgaa acatggcaaa ggtagcgttg ccaatgatgt 37860
tacagatgag atggtcagac taaactggct gacggaattt atgcctcttc cgaccatcaa 37920
gcattttatc cgtactcctg atgatgcatg gttactcacc actgcgatcc ccgggaaaac 37980
agcattccag gtattagaag aatatcctga ttcaggtgaa aatattgttg atgcgctggc 38040
agtgttcctg cgccggttgc attcgattcc tgtttgtaat tgtcctttta acagcgatcg 38100
cgtatttcgt ctcgctcagg cgcaatcacg aatgaataac ggtttggttg atgcgagtga 38160
ttttgatgac gagcgtaatg gctggcctgt tgaacaagtc tggaaagaaa tgcataagct 38220
tttgccattc tcaccggatt cagtcgtcac tcatggtgat ttctcacttg ataaccttat 38280
ttttgacgag gggaaattaa taggttgtat tgatgttgga cgagtcggaa tcgcagaccg 38340
ataccaggat cttgccatcc tatggaactg cctcggtgag ttttctcctt cattacagaa 38400
acggcttttt caaaaatatg gtattgataa tcctgatatg aataaattgc agtttcattt 38460
gatgctcgat gagtttttct aatcagaatt ggttaattgg ttgtaacact ggcttaatta 38520
ataattgcag tggaccccgg aggctatcta ataatatacc ccacaaagta aacaaaagtt 38580
aatatgcaaa tgagcttttg aattttaacg gttttggggc ggagccaacg ctgattggac 38640
gagaagcggt gatgcaaata acgtcacgac gcacggctaa cggccggcgc ggaggcgtgg 38700
cctaggccgg aagcaagtcg cggggctaat gacgtataaa aa 38742
<210> 42
<211> 42428
<212> DNA
<213> 人工序列
<220>
<223> pBWH-E04
<400> 42
ctatctatat aatatacctt attttttttg tgtgagttaa tatgcaaata aggcgtgaaa 60
atttggggat ggggcgcgct gattggctgt gacagcggcg ttcgttaggg gcggggcagg 120
tgacgttttg atgacgcgac tatgaggagg agttagtttg caagttctgg tggggaaaag 180
tgacgtcaaa cgaggtgtgg tttaaacacg gaaatactca attttcccac gctgtctaac 240
aggaaatgag gtgtttttgg gcggatgcaa gtgaaaacgg accattttcg cgcgaaaact 300
gaatgaggaa gtgaaatctg agtaatttag tgtttatgac agggaggagt atttgccgag 360
ggccgagtag actttgaccg tttacgtggg ggtttcgatt accgtgtttt tcacctaaag 420
ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgtcagggta 480
tttaaacctg cgctctgcag tcaagaggcc actcttgagt gccagcgaga agagttttct 540
cctccgcgcc gcgagtcaga tctacacttt gaaatatgag gcacctaaga gacctgcccg 600
atgaggaaat tatcatcgct tccgggagcg agattctgga actggtggta aatgctatga 660
tgggcgacga ccatccggaa ccccccaccc catttgagac accttcgctg cacgatttgt 720
atgatctgga ggtggatgtg cccgaggacg accccaacga gaaggcggta aatgatttat 780
ttagcgatgc cgcgctgcta gctgccgagg aggcttcaag ccctagctca gacagcgact 840
cttcactgca tacccctaga cacgacagag gtgagaaaga gatccccggg cttaaatggg 900
aaaagatgga cttgcgttgc tatgaggaat gcctgccccc aagcgatgat gaggacgagc 960
aggcgattca gaacgcagcg agccatggag tgcaagccgt cagcgagagc tttgcactgg 1020
actgcccgcc tttgcccgga cacggctgta agtcttgtga atttcatcgc atcaatactg 1080
gagataaagc tgtgttatgt gcactttgct atatgagagc gtacaaccat tgtgtttaca 1140
gtaagtgtga ttaagtgaac tttaaaggga ggcaaagagt agggtgactg ggtgatgact 1200
ggtttattta tgtatatctg ttttttatat aggtcccgtt tctgacgcag atgatgagac 1260
ccccactaca gagtccactt tgtcaccccc tgaaattggc acgtctccat ctgacaatat 1320
tgttagacca gttcctgtaa gagccactgg gaggagagca gctgtagaat gtttggatga 1380
tttgcttcag ggtggagatg aacctttgga cttgtgtacc cggaaacgcc ccaggcatta 1440
agtgccacac atgtgtgttt acttgaggtg atgtcagtat ttatagggtg tggagtgcaa 1500
taaaatatgt gttgacttta agtgcgtggt ttatgactca ggggagggga ctttgggtat 1560
ataagcaggt gcagacctgt gtggttagct cagagcggta tggagatttg gacggttttg 1620
gaagactttc acaagactag gcagctgcta gagaacgcct cgaacggagt ctcttacctg 1680
tggagattct gcttcggcgg tgacctagct aagctagtct atagggccaa acaggattat 1740
agggaacaat ttgaggatat tttgagagag tgtcctggtc tttttgacgc tcttaacttg 1800
ggccatcagt ctcactttaa ccagagaatt tcaagagccc ttgactttac tactcctggc 1860
agaaccactg cagcagtagc cttttttgct tttatttttg acaaatggag tcaagaaacc 1920
catttcagca gggattacca gctggatttc ttagcagtag ctttgtggag aacatggaag 1980
tgccagcgcc tgaatgcaat ctccggctac ttgccggtac agccgctaga cactctgagg 2040
atcctgagtc tccagcagca ggaggatcaa gaagagaatc cgagagccgg cctggaccct 2100
ccggcggagg agtagctgac ctgtttcctg aactgcaccg ggtgctgact aggtcttcga 2160
gtggtcggga gaggggtatt aagcgggaga ggcatgatga gactaatcac agaattgaac 2220
tgactgtggg tctgatgagc cgcaagcgtc cagaaacagt gtggtggtat gaggtgcagt 2280
caactggcac agatgaggtg tcagtcatgc atgagagatt ttccctagaa caagtcaaga 2340
cttgttggtt ggagcctgag gatgattggg aggtagccat caggaattat gccaagctgg 2400
ctctgaggcc agatagaaag tacaagatta ctaagctgat aaatatcaga aatgcctgct 2460
acatctcagg gaatggggct gaagtggaga tctgtctcca ggatagagtg gctttcagat 2520
gctgcatgat gaatatgtac ccgggagtgg tggacatgga tggggtcacc tttatgaaca 2580
tgaggttcag gggagatggg tataatggga cggtctttat ggccaatacc aagctgacag 2640
tgcatggatg ctccttcttt gggtttaata acacctgcat cgaggcttgg ggtcaggtcg 2700
gtgttaaggg gtgcagtttt tcagccaact ggatgggggt agtgggcagg accaagagta 2760
tgctgtctgt gaagaaatgc ttgtttgaga ggtgccacct gggggtgatg agcgagggcg 2820
aagccagaat ccgccactgt gcctctaccg agacgggctg ttttgtgctg tgcaagggca 2880
atgccaagat caagcataat atgatctgtg gagcctcgga cgagcgcggc taccagatgc 2940
tgacctgcgc cggtgggaac agtcatatgc tggccgccgt gcatgtggct tcccattccc 3000
gcaagccctg gcctgagttc gagcacaatg tcatgaccag gtgcaatatg catctggggg 3060
ctcgccgagg catgtttatg ccctaccagt gcaacctgaa ttatgtaaag gtgctcctgg 3120
agcccgatgt catgtccaga gtgagcctga cgggggtgtt tgacatgaat gtggaagtgt 3180
ggaagattct aagatatgat gaatacaaga ccaggtgtcg agcctgcgag tgcggaggga 3240
agcatgccag gttccagccc gtgtgtgtgg atgtgacgga ggacctgcga cccgatcatt 3300
tggtgttgtc ctgcaccggg acggagttcg gctccagtgg ggaagaatct gactagagtg 3360
agtagtgttt tggggaggga gaggacctgc ataaggggca gaatgattaa aatctgtgct 3420
tttctgtgtg ttgcagcagc atgagcggaa acggctcctt tgagggaggg gtattcagcc 3480
cttatctgac ggggcgtctc ccctcctggg cgggagtgcg tcaaaatgtg atgggatcca 3540
cggtggacgg ccggcccgta cagcccgcga actcttcaac cctgacctat gcaaccctga 3600
gctcctcgtc ggtggacgca gctgccgccg cagctgctgc ttctgccgcc agcgccgtgc 3660
gcggaatggc catgggcgcc ggctattacg gcactctggt ggccaactcg agttccacta 3720
ataatcccgc cagcctgaac gaggagaagc tgctgctgtt gatggcccag ctcgaggcct 3780
tgacccagcg cctgggcgag ctgacccagc aggtggctca gctgcaggag cagacgcggg 3840
ccgcggttgc cacggtgaaa tccaaataaa aaatgaatca ataaataaac ggagacggtt 3900
gttgatttta aaaatcagag tctgaatctt tatttgattt ttcgcgcacg gtaggccctg 3960
gaccaccggc ctcgatcatt gagcacccgg tggatctttt ccaagacccg gtagaggtgg 4020
gattggatat tgaggtacat gggcatgagc ccgtcccggg ggtgaaggta gctccattgc 4080
agggcctcgt gctcgggggt ggtgttgtaa atcacccagt catagcaggg acgcagggcg 4140
tggtgttgca caatatcttt gaggaggaga ctgatggcca cgggcagccc tttggtgtag 4200
gtgtttacaa acctgttgag ctgggaggga tgcatgcggg gggagatgag gtgcatctta 4260
gcctggatct tcagattggc gatgttaccg cccagatccc gcctgggatt catgttgtgc 4320
aggaccacca gcacggtgta tccggtgcac ttggggaatt tgtcatgcaa cttggaaggg 4380
aaggcatgaa agaatttgga gacgcccttg tggccgccca ggttttccat gcactcatcc 4440
atgataatgg ctatgggccc gtgggcggcg gcttgggcaa agacgtttcg ggggtcggac 4500
acatcgtagt tgtggtcctg ggtgagatct tcataggcca ttttaatgaa tttggggcgg 4560
agggtgcccg attgggggac gaaggtaccc tcaatcccgg gggcgtagtt tccctcacag 4620
atctgcatct cccaggcctt aagctccgag ggggggatca tgtccacctg cggggcgata 4680
aagaaaacgg tttccggggc gggggagatg agctgggcgg aaagcaggtt gcggagtagc 4740
tgggacttac cgcagccggt ggggccgtag ataaccccaa tgaccggctg caggtggtag 4800
ttgagggaga cacagctgcc gtcctcccta agaagggggg ccacctcgtt catcatttgg 4860
cgcacgtgca tgttctcgcg caccagttcc gccaggagtc gctctccgcc cagcgagagg 4920
agctcctgga gcgaggcgaa gtttttcagc ggcttgagcc cgtcggccat gggcattttg 4980
gaaagggtct gttgcaggag ttccaagcgg tcccagagct cggtgatgtg ctctacggca 5040
tctcgatcca gcagacctcc tcgtttcgcg ggttggggcg actgcgggag tagggcgcca 5100
gacgatgggc gtccagcgcg gccagggtcc ggtccttcca gggtcgcagc gtccgcgtca 5160
gggtggtctc cgtcacggta aaggggtgcg cgccgggctg ggcgcttgcg agggtgcgct 5220
tcaggctcat ccggctggtc gagaaccgct cccgatcggc gccctgtgcg tcggccaggt 5280
agcaattgac catgagttcg tagttgagcg cctcggccgc gtggcctttg gcgcggagct 5340
tacctttgga agtctgccca caggcgggac agaggaggga cttgagggcg tagagcttgg 5400
gggcgaggaa gacggactcg ggggcgtagg cgtccgcgcc gcagtgggcg cagacggtct 5460
cgcactccac gagccaggtg aggtcgggct gattgggatc aaaaaccagt tttccgccgt 5520
tctttttgat gcgtttctta cctctggtct ccatgagctc gtgtccccgc tgggtgacaa 5580
agaggctgtc cgtgtccccg taaaccgact ttatgggtcg gtcctcgagt gggacgccgc 5640
ggtcctcgtc gtagaggaaa cccgaccact ctgagacgaa ggcccgggtc caagccagca 5700
cgaaggaggc cacgtgggag ggatagcggt cgttatccac cagcgggtcc accttctcca 5760
gtgtatgcaa acacatgtcc ccctcgtcca catccaggaa ggtgattggc ttgtaagtgt 5820
aggccacgtg accgggggtc ccggccgggg gggtataaaa gggggcgggc cgctgctcgt 5880
cttcactgtc ttccggatcg ctgtccagga gcgccagctg ttggggtagg tattccctct 5940
caaaggcggg catgacctcc gcactcaggt tgtcagtttc tagaaacgag gaggatttga 6000
tattgacggt gccggcggag atgcctttca agagcccctc gtccatctgg tcagaaaaga 6060
caatcttttt gttgtcgagt ttggtggcga aggagccgta gagggcgttg gagaggagct 6120
tggcgatgga gcgcatggtc tggttctttt ccttgtcggc gcgctccttg gcggcgatgt 6180
tgagctgcac gtactcgcgc gccacgcact tccattcggg gaagacggtg gttagctcgt 6240
ctggcacgat tctgacctgc cagccccggt tatgcagggt gatgaggtca acgctggtgg 6300
ccacctcgcc gcgcaggggc tcgttggtcc agcagaggcg gccgcccttg cgcgagcaga 6360
aggggggcag ggggtccagc ataagctcgt cgggggggtc agcatcgatg gtgaagatgc 6420
ctggcaggag gtcggggtcg aagtagctta tgcaggtgcc cagatcgtcc agagaagctt 6480
gccattcgcg cacggccagc gcgcgctcgt agggactaag gggcgtgccc cagggcatgg 6540
ggtgggtgag cgcggaggcg tacatgccgc agatgtcgta gacgtagagg ggctcatcaa 6600
ggatgccaat gtaggtgggg tagcagcggc ccccgcggat gctggcgcgc acgtagtcat 6660
acaactcgtg cgagggggcg aggagcccgg ctccgagatt ggcgcggctg ggtttttcgg 6720
cgcggtagac gatctgacgg aagatggcgt gggagttgga ggagatggtg ggtctttgga 6780
agatgttgaa gtgggcgtgg ggcaggccga ccgagtcgcg gatgaagtgg gcgtaggagt 6840
cttgcagctt ggcgacaagc tcggcggtga cgaggacgtc cagggcgcag tagtcaaggg 6900
tctcttggat gatgtcatac ttgagctggc ccttttgttt ccacagctcg cggttgagaa 6960
ggaactcttc gcggtccttc cagtactctt caagggggaa cccgtcctgg tcggcacggt 7020
aagagcctag catgtagaac tggttaacgg ccttgtaggc gcagcagccc ttctccacgg 7080
ggagggcata ggcctgggcg gccttgcgca gggaggtgtg cgtgagggcg aaggtgtccc 7140
tgaccatgac ctttaggaac tggtgcttga agtcgatatc gtcgcagccc ccctgctccc 7200
agagctggaa gtccgtgcgc ttcttgtagg cggggttggg caaagcgaaa gtaacatcgt 7260
tgaagaggat cttgcccgcg cggggcataa agttgcgagt gatgcggaaa ggctggggca 7320
cctcggcccg gttgttgatg acctgggcgg cgagcacgat ctcgtcgaag ccgttaatgt 7380
tgtggcccac aatgtatagt tccacgaacc gcgggcggcc cttgacgtgg ggcagtttct 7440
tgagctcctc gtaggtgagc tcgtcggggt cgctgagccc gtgctgctcg agggcccagt 7500
cggcgagatg ggggttggcg cggaggaagg aagtccagag atccacggcc agggcggttt 7560
gcagacgatc ccggtactgg cggaactgct gacccacggc cattttttcg ggggtgacgc 7620
agtagaaggt gcgggggtcg ccgtgccaac ggtcccattt tagctggagg gcgagatcaa 7680
gggcgagctc aacgagccgg tcgtccccgg agagtttcat gaccagcatg aaggggacga 7740
gctgcttgcc gaaggacccc atccaggtgt aggtttccac atcgtaggtg aggaagagcc 7800
tttcggtgcg aggatgcgag ccgatgggga agaactggat ctcctgccac cagttggagg 7860
aatggctgtt gatgtgatgg aagtagaaat gccgacggcg cgccgaacat tcgtgcttgt 7920
gtttatacaa gcggccacag tgctcgcaac gctgcacggg atgcacgtgc tgcacgagct 7980
gtacctgggt tcctttgacg aggaatttca gtgggaagtg gagtcgtggc gcctgcatct 8040
ggtgctgtac tacgtcgtgg tggtcggcct ggccctcttc tgcctcgatg gtggtcatgc 8100
tgacgagccc gcgcgggagg caggtccaga cctcggcgcg aacgggtcgg agagcgagga 8160
cgagggcgcg caggccggag ctgtccaggg tcctgagacg ctgcggagtc aggtcagtgg 8220
gcagcggcgg cgcgcggttg acttgcagga gtttttcaag ggcgcgcggg aggtccagat 8280
ggtacttgat ctccaccgcg ccgttggtgg cgacgtcgat ggcttgcagt gtcccgtgcc 8340
cctggggagt gaccaccgtc ccccgtttct tcttggcggg cggaagcggt ttggcttcca 8400
tggttaaaag cggcggcgag gacgcgcgcc gggcggtagg ggcggctcgg gacccggagg 8460
cagtggtggc aggggcacgt cggcgccgcg cgcgggcagg ttctggtact gcgcccggag 8520
aagactggcg tgagcgacga cgcgacggtt gacgtcctgg atctgacgcc tctgggtgaa 8580
ggccacggga cccgtgagtt tgaacctgaa agacagttcg acagaatcaa tctcggtatc 8640
attgacggcg gcctgccgca gaatctcttg cacgtcgccc gagttgtcct ggtaggcaat 8700
ctcggtcatg aactgctcga tctcctcctc ctgaaggtct ccgcggccgg cgcgctccac 8760
ggtggccgcg aggtcgttgg agatgcggcc catgagctgc gagaaggcgt tcatgcccgc 8820
ctcgttccag acgcggctgt aaaccacggc gccctcggga tcgcgggcgc gcatgaccac 8880
ctgggcgagg ttgagctcca cgtggcgcgc aaaaaccgcg tagttgcaga ggcgctggta 8940
gaggtagttg agcgtggtgg caatgtgctc agtgacaaag aagtacataa tccagcggcg 9000
gagcggcatt tcgctgacgt cgcccagggc ttccaagcgc tccatggcct cgtaaaagtc 9060
cacggcgaag ttgaaaaact gggagttgcg tgcagatacg gtcaagtcct cctccagaag 9120
acggatgagc tcggcgatgg tggcgcgcac ctcgcgctcg aaggctcccg ggagttcctc 9180
cacttcctcc tcttcatcca ctaacatctc ttctacttcc tcctcaggcg gtggtggcgg 9240
gggagggggc ctgcgtcgcc ggcggcgcac gggcagacgg tcgatgaaac gctcgatggt 9300
ctcgccgcgc cggcgtcgca tggtctcggt gacggcgcgc ccgtcctcgc ggggtcgcag 9360
cgtaaagacg ccgccgcgca tctccaggtg gcccgggggg tccccgttgg gcagggagag 9420
tgcgctgacg atgcatctta tcaattgccc cgtagggact ccgcgcaagg acctaagcgt 9480
ctctagatcc acgggatctg aaaaccgttg aacgaaggct tcgagccagt cgcagtcgca 9540
aggtaggctg agcacggttt cttctggcgg cggtggggtg tgggcggggg cgatgctgct 9600
ggtgatgaag ttgaaatagg cggttctgag acggcggatg gtggcgagga gcaccaggtc 9660
tttgggcccg gcttgctgga tgcgcagacg gtcggccatg ccccaggcgt ggtcctgaca 9720
cctggccagg tccttgtagt agtcctgcat gagccgctcc acgggcacct cctcctcgcc 9780
cgcgcggccg tgcatacgcg tgagcccaaa cccgcgctgc ggctggacga gcgccaggtc 9840
agcgacgacg cgctcggcga ggatggcctg ctggatctgg gtgagggtgg tctggaagtc 9900
gtcaaagtcg acgaagcggt ggtaggctcc ggtgttaatg gtgtaggagc agttggccat 9960
gacggaccag ttgacagtct ggtgaccggg ccgcgcgagc tcgtggtact tgaggcgcga 10020
gtaggcgcgc gagtcgaaga tgtagtcgtt gcaggtgcgc accaggtact ggtagccgat 10080
gaggaagtgc ggcggcggct ggcggtagag cggccatcgc tcggtggcgg gggcgccggg 10140
cgctaggtcc tcgagcatgg tgcggtggta gccgtagatg taccttgaca tccaggtgat 10200
gccggcggcg gtggtggagg cgcgagggaa ctcgcggacg cggttccaga tgttgcgcag 10260
cggcaggaag tagttcatgg tgggcacggt ctggcccgtg aggcgcgcgc agtcgttgat 10320
gctctagaca tacgggcaaa aacgaaagcg gtcagcggct cgactccgtg gcctggaggc 10380
taagcgaacg ggttgggctg cgcgtgtacc ccggttcgaa tctcgaatca ggctggagcc 10440
gcagctaacg tggtactggc actcccgtct cgacccaggc ctgcacaaaa cctccaggat 10500
acggaggcgg gtcgttttgc aaatttttgg cggtcgaaaa aagctagtaa gcgcggaaag 10560
cggccgaccg caatggctca ctgccgtaga ttggagaaga atcgccaggg ttgcgttgcg 10620
gtgtgccccg gttcgagacc gctcgggtcg gccgaattcc gcggctaacg agggcgtggc 10680
tgccccgtcg tttccaagac cccataagcc agccgacttc tccagttacg gagcgagccc 10740
ctcttttgtt ttgttttttg ccagatgcat cccgtactgc ggcagatgcg cccccaccct 10800
ccaccgcaac agcagccccc tcctacgcaa cagccggcgc ttctgcctcc gccccagcag 10860
cagcaacttc cagccactac cgccgcggcc gccgtgagcg gggccgggca gagtcagtat 10920
gacctggctt tggaagaggg cgaggggctg gcgcgcctgg gggcgtcgtc gccggagcgg 10980
cacccgcgcg tgcagatgaa aagggacgct cgcgaggcct acgtgcccaa gcagaacctg 11040
ttcagagaca ggagcggcga ggagcccgag gagatgcgcg cagcccgttt ccacgcgggg 11100
cgggagctgc ggcgcggcct ggacagaaag agggtgctga gggacgagga tttcgaggcg 11160
gacgagctga cggggatcag ccctgcgcgc gcgcacgtgg ccgcggccaa cctggtcacg 11220
gcgtacgagc agaccgtgaa ggaggagagc aacttccaaa aatccttcaa caaccacgtg 11280
cgcaccctga tcgcgcgcga ggaggtgacc ctgggcctga tgcacctgtg ggacctgctg 11340
gaggccattg tgcagaaccc caccagcaaa ccgctgacgg cgcagctgtt cctggtggtg 11400
cagcacagtc gggacaacga gacttttagg gaggcgctgc tgaatatcac cgagcccgag 11460
ggccgctggc ttctggacct ggtgaatatt ctgcagagca tcgtggtgca ggagcgcggg 11520
ctgccgctgt ccgagaagct ggcggccatc aacttttcgg tgctgagttt gggcaagtac 11580
tacgctagga agatctacaa gaccccgtac gtgcccatag acaaggaggt gaagatcgac 11640
gggttttaca tgcgcatgac cctgaaagtg ctgaccctga gcgacgatct gggggtgtac 11700
cgcaacgaca ggatgcgccg cgcggtaagc gccagcaggc ggcgcgagct gagcgatcag 11760
gagctgatgc acagcctgca gcgggccctg accggggccg ggaccgaggg ggagagctac 11820
tttgacatgg gcgcggacct gcactggcag cccagccgcc gggtcttgga agccgcggcg 11880
gtcccttacg tagaagaggt ggacgatgag gatgagggcg agtacctgga agactgatgg 11940
cgcgaccgta tttttgctag atgcagcaac agccacctcc tgatcccgca atgcgggcgg 12000
cgctgcagag ccagccgtcc ggcattaact cctcggacga ttggacccag gccatgcaac 12060
gcatcatggc gctgacgacc cgcaaccccg aagcctttag acagcagccc caggccaacc 12120
ggctctcggc catcctggag gccgtggtgc cctcgcgctc caaccccacg cacgagaagg 12180
tgctggccat cgtgaacgcg ctggttgaga acaaggccat tcgcggcgac gaggccgggc 12240
tggtgtacaa cgcactgctg gagcgcgtgg cccgctacaa cagcaccaac gtgcagacca 12300
acctggaccg catggtgacc gacgtgcgcg aagccgtggc ccagcgcgaa cggttccacc 12360
gcgagtccaa cctgggatcc atggtggcac tgaacgcctt cctcagcacg cagcccgcca 12420
acgtgccccg gggccaggag gactacacca acttcattag cgccctgcgg ctaatggtga 12480
ccgaggtgcc ccagagcgag gtgtaccagt cgggcccgga ctacttcttc cagaccagtc 12540
gccagggctt gcagaccgtg aacctgagtc aggctttcaa gaacttgcag ggactgtggg 12600
gcgtgcaggc tccggtcggg gaccgcgcga cggtgtcgag cctgctgacg ccgaactcgc 12660
gcctgctgct gctgctggtg gcgcccttca cggacagcgg tagtatcaac cgcaactcgt 12720
acctgggcta cctgattaac ctgtaccgcg aggccattgg ccaggcgcac gtggacgagc 12780
agacctacca ggagattacc cacgtgagcc gcgccctcgg ccaggacgac ccgggcaatc 12840
tggaagccac cctgaacttc ttgctgacca accggtcgca gaagatcccg ccccagtacg 12900
cgctgagcgc cgaggaggag cgtatattga gatacgtgca gcaaagtgtg ggactgttcc 12960
tgatgcagga gggggccacc cccagcgccg cgctcgacat gaccgcgcgc aacatggagc 13020
ccagcatgta cgccagtaat cgcccgttta ttaataagct gatggactac ctgcatcggg 13080
cggccgccat gaactctgac tatttcacca acgccatcct gaacccccac tggctcccgc 13140
cgccggggtt ctacacgggc gagtacgaca tgcccgaccc caatgacggg tttctgtggg 13200
acgacgtgga cagcagcgtg ttctcccccc gaccgggtgc taacgagcgc cccttgtgga 13260
agaaagaggg cagcgaccgg cgcccgtcct cggcgctgtc cggccgcacg ggtgctgccg 13320
cagcggtgcc cgaggccgcc agtccctttc cgagcttgtc actgaacagc gtccgcagta 13380
gcgagctggg caggatcacg cgcccgcgct tgctgggcga ggaggagtac ttaaataact 13440
cgctgttgag gcccgagcgg gagaagaact tccccaataa cgggatagag agtctggtgg 13500
ataagatgag ccgctggaag acgtacgcgc atgagcacag ggacgatccc cgggcaacgc 13560
agggggccac cagccggggc agtgccgccc gtaaacgccg ctggcacgac aggcagcggg 13620
gactgatgtg ggacgatgag gattccgccg acgacagcag cgtgttggac ttgggcggga 13680
gtggtggtgg taacccgttc gctcacctgc gcccccgcgt cgggcgcctg atgtaaaaag 13740
aaaccaaaaa taaatggtac tcaccaaggc catggcgacc agcgtgcgtt cgtttcttct 13800
ctgttgtatc tagtatgatg aggcgtgcgt acccggaggg tcctcctccc tcgtacgaga 13860
gcgtgatgca gcaggcaatg gcggcggcgg cggcgatgca gcccccgctg gaggctcctt 13920
acgtgccacc gcggtacctg gcgcctacgg aggggcgaaa cagcattcgt tactcggagc 13980
tggcaccctt gtacgatacc acccggttgt acctggtgga caacaagtcg gcggacatcg 14040
cctcgctgaa ctaccagaac gaccacagca actttctgac caccgtggtg cagaacaacg 14100
atttcacccc cacggaggcc agcacccaga ccatcaactt tgacgagcgc tcgcggtggg 14160
gcggtcagct gaaaaccatc atgcatacca acatgcccaa cgtgaacgag ttcatgtaca 14220
gcaacaagtt caaggcgcgg gtcatggtct cccgcaagac ccccaacggg gtgacagtag 14280
gggatgatta tgatggtagt caggatgagc tgaaatacga gtgggtggag tttgagctgc 14340
ccgaaggcaa cttctcggtg accatgacca ttgacctgat gaacaacgcc atcatcgaca 14400
attacttggc agtggggcgg cagaacgggg tgctggagag cgacatcggc gtgaagttcg 14460
acacccggaa cttcaggctg ggttgggacc ccgtgaccga gctggtcatg cccggggtgt 14520
acaccaacga ggccttccac cccgacatcg tgctgttgcc cggctgcggg gtggacttta 14580
ccgagagccg cctcagtaat atgctgggca tccgcaagag gcagcccttc caggagggtt 14640
tccagatcat gtacgaggac ctggatggag gtaacatccc cgcgctcttg gatgtcgagg 14700
cctatgagaa aagcaaggag gagagcgtcg ccgcgtcaac cgcagccgta gccaccgcct 14760
ctaccgaggt ccggggcgat aattttgcta gcgccgcagc agtggcggcg gccaaggctg 14820
atgaaaccga aagtaagata gttattcagc cggtggagaa ggatagcaag gataggagct 14880
acaacgtgct ctcggacaag aaaaacaccg cctaccgcag ctggtacctg gcctacaact 14940
atggcgacca cgagaagggc gtgcgctcct ggacgctgct caccacctcg gacgtcacct 15000
gcggcgtgga gcaagtctac tggtcgctgc ccgacatgat gcaagacccg gtcaccttcc 15060
gctccacgcg tcaagttagc aactacccgg tggtgggcgc cgagctcatg cccgtctact 15120
ccaagagctt cttcaacgag caggccgtct actcgcagca gctgcgcgcc ttcacctcgc 15180
tcacgcacgt cttcaaccgc ttccctgaga accagatcct cgtccgcccg cccgcgccca 15240
ccattaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacc ctgccgctgc 15300
gcagcagtat ccggggagtc cagcgcgtga ccgttactga cgccagacgc cgcacctgcc 15360
cctacgtcta caaggccctg ggcatagtcg cgccgcgcgt cctctcgagc cgcaccttct 15420
aaaaaatgtc cattctcatc tcgcccagta ataacaccgg ttggggtctg cgcgcgccca 15480
gcaagatgta cggaggcgct cgccaacgct ccacgcaaca ccccgtgcgc gtgcgcgggc 15540
acttccgcgc tccctggggc gccctcaagg gccgcgtgcg gtcgcgcacc accgtcgacg 15600
acgtgatcga ccaggtggtg gccgacgctc gcaactacac ccccgccgcc gcgcccgtct 15660
ccaccgtgga cgccgtcatt gacagcgtgg tgtccgacgc gcgccggtac gcccgcgcca 15720
agagccggcg gcggcgcatc gcccggcggc accgtagcac caccgccatg cgtgcggcgc 15780
gagccttgct gcgcagggcc aggcgcacgg gacgcagggc catgctcagg gcggccagac 15840
gcgcggcttc aggcgccagc gccggcagga ctcggagacg cgcggccacg gcggcggcag 15900
cggccatagc cagcatgtcc cgcccgcggc gagggaacgt gtactgggtg cgcgacgccg 15960
ccaccggtgt gcgcgtgccc gtgcgcaccc gcccccctcg cacttgaaga tgttcacttc 16020
gcgatgttga tgtgtcccag cggcgaggag aaggatgtcc aagcgcaaat tcaaggaaga 16080
gatgctccag gtcatcgcgc ctgagatcta cggccccgcg gcggcggtga aggatgaaag 16140
aaatccccgc aaaatcaagc gggtcaaaaa ggacaaaaag gaagaagatg atgtggacga 16200
tatggtagag tttgtgcgcg agtttgcccc ccggaggcgc gtgcagtggc gcgggcggaa 16260
agtgcgtccg gtgctgagac ccggcaccac ggtggttttc gcgcctggcg agcggtccgg 16320
cacgacatcc aagcgctcct acgatgaggt gtacggggac gaggatattc tcgagcaggc 16380
ggccgagcgc ctgggcgagt ttgcttacgg caagcgcaac cgccttgcgc ccctgaagga 16440
agaggtggtg tccatcccgc tggaccacgg caaccccacg ccgagtctta agcccgtgac 16500
cctgcagcag gtgctgccga gcgcggcgcc gcgtcggggc ttgaagcgcg agggcgagga 16560
tgtgtacccc accatgcagc tgatggtgcc caagcgccag aagctggaag acgtgctgga 16620
gaccatgaag gtggacccgg acgtgcagcc cgaggtcaag gtgaggccca tcaagcaggt 16680
ggccccgggc cttggcgtgc agaccgtgga catcaagatc cccacggagc ccatggaaac 16740
gcagaccgag gtcgtgaagc ccatcaccag caccatggag gtgcagacgg atccttggat 16800
gccggcggcg ccccgaaaac cccggcgcaa gtacggcgcg gccagcctgc tgatgcccaa 16860
ctacgcgctg catccttcca tcatccccac gccgggctac cgcggcacgc gcttctacca 16920
cggctatacc ggctcccgcc gccgcaagac caccacccgc cgccgtcgtc gccgcacagc 16980
tgcaactccc gctgccgccc tggtgcggag agtgtaccgc cgcggccgcg cgcctctgac 17040
cctgccgcgg gcgcgctacc acccgagcat taccatttaa ctttgccgtc gcctttgcag 17100
atatggctct cacatgccgc attcgcgtcc ccattacggg ctaccgagga agaaaaccgc 17160
gccgtagaag gctggcggga agcgggatgc gccgccaccc ccaccggcgg cggcgcgcca 17220
tcagcaagcg gttgggggga ggcttcctgc ccgcgctgat ccccatcatc gccgcggcga 17280
tcggggcgat ccccggcatt gcttccgtgg cggtgcaggc ctctcagcgc cactgagaca 17340
cacacttgga aattgtaata aacccgaatg gactctgacg ctcctggtcc tgtgatgtgt 17400
ttttgtagac agatggaaga catcaatttt tcgtccctgg ctccgcgaca cggcacgcgg 17460
ccgtttatgg gcacctggag cgacatcggc accagccaac tgaacggggg cgccttcaat 17520
tggagcagtc tctggagcgg gcttaagaat tttgggtcca cgcttaaaac ctatggcagc 17580
aaggcgtgga acagcaccac agggcaggcg ctgagagata agctgaaaga gcagaacttc 17640
cagcagaagg tagtcgatgg cctcgcctca ggcatcaacg gggtggtgga cctggccaat 17700
caggccgtgc agcggcagat caacagccgc ctggacccgg ttccccccgc cggctccgtg 17760
gagatgccgc aggtggagga ggagctgcct cccctggaca agcggggcga caagcgtccc 17820
cgtcccgacg cggaggagac gctgctgacg cacacggacg aaccgccccc gtacgaggag 17880
gcggtgaaac tgggcctgcc caccacgcgt cccattgcgc ctctagctac cggggtgctg 17940
aaacccgaga gtagtaagcc cgcgaccttg gacttgcctc ctccgcccac tccccgcccc 18000
tccacagtgg ctaagcccct gccgccggtg gccgtggccc gcgcgcgacc gggggctcgc 18060
cctcaggcga actggcagag cactctgaac agcatcgtgg gtctgggagt gcagagtgtg 18120
aagcgccgcc gctgttatta aaaaacactg tagcgcttaa cttgcttgtc tgtgtatatg 18180
tgtatgtccg ccgccgctgc tgtccagaag gaggagtgaa gagaaaggcg cgtcgtcgag 18240
ttgcaagatg gccaccccat cgatgctgcc ccagtgggcg tacatgcaca tcgccggaca 18300
ggacgcttcg gagtacctga gtccgggtct ggtgcagttc gcccgcgcca cagacaccta 18360
cttcagtctg gggaacaagt ttaggaaccc cacggtggcg cctacccacg atgtgaccac 18420
cgaccgcagc cagcggctga cgctgcgctt tgtgcccgtg gaccgggagg acaacaccta 18480
ctcgtacaaa gtgcgctaca cgctggccgt gggcgacaac cgcgtgctgg acatggccag 18540
cacctacttt gacatccgcg gcgtgctgga tcggggccct agcttcaaac cctactccgg 18600
cactgcctac aacagcctgg ctcccaaggg agcgcccaac acctgccagt ggaaggattc 18660
tgacagcaaa atgcatacct ttggggcagc tgccatgccc ggtgttactg ggaaaaagat 18720
agaagctgat gggctgccta ttagaataga ttcaacttct ggaactgaca cagtaattta 18780
tgctgataaa actttccaac cagaaccaca agttggaaat gacagttggg ttgacaccaa 18840
tggtgcagag gaaaaatatg gaggcagagc tctaaaggac actacaaaaa tgaaaccctg 18900
ttatggttca ttcgccaagc ctaccaacaa agaaggtggt caggctaact taaaagattc 18960
agaacccgcc gccaccactc ctaactatga tatagacctg gctttctttg acagcaaaac 19020
tattgttgct aactacgatc cagatattgt aatgtacaca gaaaatgttg acttgcagac 19080
tccagatact catattgtat acaaacctgg aacagaggac accagctctg aatccaattt 19140
gggtcagcag gccatgccta acagacccaa ctacattggc ttcagagaca attttatcgg 19200
gctcatgtac tacaacagca ctggcaatat gggggtgctg gccggtcagg cctctcagct 19260
gaatgctgtg gttgacttgc aagacagaaa cactgaactg tcctaccagc tcttgcttga 19320
ctctctgggt gacagaaccc ggtatttcag tatgtggaat caggcggtgg acagctatga 19380
tcctgatgtg cgcattattg aaaaccatgg tgtggaggat gaattgccaa actattgctt 19440
tccgttgaat ggtgtgggat tgacagacac ttaccagggt gttaaagtta aaacagatgc 19500
aggttctgaa aagtgggaca aagatgacac cacagttagt aatgctaatg aaatccatgt 19560
aggcaatcct tttgccatgg aaatcaacat ccaagccaac ctgtggagga acttcctcta 19620
tgccaatgtt gccctctatt tgcctgataa atacaaatac acaccggcca acatcaccct 19680
gcccaccaac accaacacct acgagtacat gaacggccgg gtggtggcgc cctcgctggt 19740
ggacgcctac attaacattg gggcgcgctg gtcgctggac cccatggaca acgtaaatcc 19800
cttcaaccac caccgcaatg cgggcttgcg ctaccgctcc atgctcctgg gcaacgggcg 19860
ctacgtgcca ttccacatcc wggtgcccca gaaatttttt gccattaaga gcctcctgct 19920
cctgcccggg tcctacacct acgagtggaa cttccgcaag gacgtcaaca tgatcctgca 19980
gagttccctt ggcaacgacc tgcgcacaga cggggcctcc atcaccttca ccagcattaa 20040
cctctacgcc accttcttcc ccatggcgca caacaccgcc tccacgcttg aggccatgct 20100
gcgcaacgac accaatgacc aatccttcaa cgactacctc tcggcggcca acatgctcta 20160
tcccatcccg gccaacgcca ccaacgtgcc catctccatc ccctcgcgca actgggccgc 20220
ctttcgcggc tggtccttca cgcgactcaa gaccaaagag acgccctcgc tgggctccgg 20280
gttcgacccc tacttcgtct actcgggctc catcccctac ctcgacggca ccttctacct 20340
caaccacacc ttcaagaagg tctccatcac cttcgactct tccgtcagct ggcccggcaa 20400
cgaccggctc ctgacgccca acgagttcga aatcaagcgc accgtcgacg gcgagggata 20460
caacgtggcc cagtgcaaca tgaccaagga ctggttcctg gtccagatgc tggcccacta 20520
caacatcggc taccagggct tctacgtgcc cgagggctac aaggaccgca tgtactcctt 20580
cttccgcaac ttccagccca tgagccgcca ggtggtggac gaggttaact acaaggacta 20640
ccaggccgtc accctggcct accaacacaa caactcgggc ttcgttggat acctcgcgcc 20700
cactatgcgc cagggccagc cctaccccgc caactacccc tacccgctca tcggcaagag 20760
cgccgttacc agcgtcaccc agaaaaagtt catctgcgac agggtcatgt ggcgcatccc 20820
cttctccagc aacttcatgt ccatgggcgc gctcaccgac ctcggccaga acatgctcta 20880
tgctaactcc gcccacgcgc tagacatgaa tttcgaagtc gaccccatgg atgagtccac 20940
ccttctctat gttgtcttcg aagtcttcga cgtcgtccga gtgcaccagc cccaccgcgg 21000
cgtcattgag gccgtctacc tgcgcacccc cttctcagcc ggtaacgcca ccacataaat 21060
tcttgcttct tgcaagaagc catggccgcg ggctccggcg agcaggagct cagggccatc 21120
atccgcgacc tggggtgcgg gccctacttc ctgggcacct tcgataagcg attcccggga 21180
ttcatggccc cgcacaaggt ggcctgcgcc atcgtcaaca cggccggccg cgagaccggg 21240
ggcgagcatt ggctggcctt cgcctggaac ccgcgctcga acacctgcta cctcttcgac 21300
cccttcgggt tctcggacca gcgcctcaag caaatctacc agttcgagta cgagggactg 21360
ctgcgccgca gcgccctggc caccaaggac cgctgcgtta ccctggaaaa gtccacccag 21420
accgtgcagg gtccgcgttc ggccgcctgc gggcttttct gctgcatgtt cctacacgcc 21480
ttcgtgcact ggcccaaccg ccccatggac aaaaatccca ccatgaactt gctgacgggg 21540
gtgcccaacg gcatgctcca gtcgccccag gtggaaccta ccctgcgccg caaccaggag 21600
gcactctacc gcttcctcaa ctcccactct gcatactttc gctctcaccg cgcgcgcatt 21660
gagaaggcca ccgccttcga ccgcatgaat caagacatgt aacagtgtgt tttaaaatat 21720
gtttaataaa cagcactttt tatgtgacac atgcatttga gataatttta ttcttaaaaa 21780
tcgaaggggt tctgccggga ggtttcggca tggcccgcgg gcagggacac gttgcggaac 21840
tggtacttgg ccagccactt gaactcgggg atcagcagtt tcggcagcag ggtgtcgggg 21900
aacgagtcgg tccacagctt ccgcgtcagt tgcagggcgc ccagcaggtc gggcgcggag 21960
atcttgaaat cgcagttggg acccgcgttt tgcgcgcgag agttgcggta cacagggttg 22020
cagcactgga acaccatcag ggccggatgc ttcacgctcg ccagcaccgt agcgtcggtg 22080
atcccgtcca cgtcgaggtc ttcggcgttg gccatcccga agggggtcat cttgcaggtc 22140
tgccggccca tggtgggcac gcagccgggc ttgtggttgc aatcgcagtg cagggggatc 22200
agcatcatct gggcctggtc ggcgttcatc cccgggtaca tggccttcat gaaagcctcc 22260
agctgcttaa acgcctgctg ggccttggct ccctcggtga agaagacccc gcaggacttg 22320
ctagaaaact ggttggtagc gcacccggcg tcgtgcacgc agcagcgcgc gtcgttgttg 22380
gccagctgca ccacgctgcg cccccagcgg ttctgggtaa tcttggcccg gtcggggttc 22440
tcctttagcg cgcgttgccc gttctcgctt gccacatcca tctcgatcat gtgctccttc 22500
tggatcatgg tggtcccgtg caggcaccgc agcttgccct cgacttcggt acagccgtgc 22560
agccacagcg cgcaccccgt gctctcccag ttcttgtggg cgatctggga atgcgcatgc 22620
acgaacccct gcaggaagcg gcccatcatg gtcgtcaggg tcttgttact ggtaaaggtc 22680
agcggaatgc cgcggtgctc ctcgttgatg tacaggtggc agatgcggcg atacacctcg 22740
ccctgctcgg gcatcagttg gaagttggat tttaggtcgc tttccacacg gtagcgctcc 22800
atcagcatat tcatgatttc catgcccttc tcccaggccg atacaatggg caggctcagg 22860
gggttcgtca ccgccatctt agcgctagca gccttcgtca gcgggtcgtt ctcattgaga 22920
gtctcaaagc tccgcttgcc gtccttctcg gtgatccgca cgggggggta gctgaagccc 22980
acggccgcca gctcctcctc ggcctctctt tcgtcctcgc tgtcctggct gacgtcctgc 23040
aggggcacat gcttcgtttt gcggggtttc tttttgggcg gctgctgcgg cggcggtggt 23100
tgttcctgag gcgaggggga gcgcgagttc tcgctcacca ctactatctc ttcttcttgg 23160
tccgaggcca cgcggcggta ggtatgtctc ttcaggggca gaggcggagg cgacgggctc 23220
tcgcggcccg gcgggtggct ggcagagccc cttccgcgat cgggggtgcg ctcccggcgg 23280
cgctctaact gacttcctcc gcggccggcc attgtgttct cctagggaac aacaacaagc 23340
atggagactc agccatcgtc gccaacctcg ccatctgccc ccaccgccga caagaagcag 23400
cagcagaatg agagcttaac cgccccgccg cccagccccg ccacctttgt cgcggcccca 23460
gacatgcaag agatggagga atccattcag attgacctgg gctatgtgac gcccgcggag 23520
cacgaggagg agcttgcagt gcgcttttca acccaggaag agatacacca agaacagcca 23580
gagcaggaag caaagagcga gcatgactac ctccaccaga gcggggggga ggacgccctc 23640
atcaagcatc tggcccggca ggccatcatc gtcaaggacg cgctgcttga ccgcaccgag 23700
gtgcccctca gcgtggagga gctcagccgc gcctacgagc tcaacctctt ctcgccgcgc 23760
gtgcccccca agcgccagcc caacggcacc tgcgagccca acccacgcct caacttctac 23820
ccggtcttcg cggtgcccga ggccctggcc acctaccaca tctttttcaa gaaccaaagg 23880
atccctgtct cctgtcgcgc caaccgcacc cgcgccgact cccttttcaa cctgggcccc 23940
ggtgcccgcc tacctgatat cgcctccttg gaagaggttc ccaagatctt cgagggtctg 24000
ggcagcgacg agactcgggc cgcaaacgct ctgcaaggag aaggaggaga tcatgagcac 24060
cacagcgccc tggtggagtt ggaaggcgac aacgcgcgtc tggcggtgct caagcgcacg 24120
atcgagctga cccatttcgc ctacccggcg cttaacctgc cccccaaagt catgagcacg 24180
gttatggacc aggtgctcat caagcgcgcg tcgcccatct ccaaggagat gcaagacccc 24240
gagagctccg aggagggcaa gcccgtggtc agcgacgagc agctggcgcg gtggctggga 24300
ccccaagcta gtccccagag cttggaagag cggcgcaagc tcataatggc cgtggtcctg 24360
gtgaccgcgg agctggagtg tctgcgccgc ttcttcgccg acgcagaaac tctgcgcaag 24420
gtcgaggaga acctgcacta catcttcagg cacgggttcg tacgccaggc ctgcaagatc 24480
tccaacgtgg agctgaccaa cctggtctcc tacatgggca tcttgcacga gaaccgcctg 24540
gggcagaacg tgctgcacac caccctgcgc ggggaggccc gccgcgacta catccgcgac 24600
tgcgtttacc tctacctctg ccacacctgg cagacagcca tgggcgtgtg gcagcagtgt 24660
ctggaggagc agaacctaaa agagctctgc aagctcctgc agaagaacct caaggccctg 24720
tggaccgggt tcgacgagcg caccaccgcc tcggacctgg cagacctcat tttccccgag 24780
cgtctcaggc tgacgctgcg caacggtttg cccgacttta tgagtcaaag catgttgcaa 24840
aactttcgct ctttcatcct cgaacgctcc gggatcctgc cggccacctg ctccgcgctg 24900
ccctcggact tcgtgccgct gaccttccgc gagtgccccc cgccgctgtg gagccactgc 24960
tacctgctgc gcttggccaa ctacctggcc taccactcgg acgtgatcga ggacgtcagc 25020
agcgagggcc tgctcgagtg ccactgccgc tgcaacctct gcacgccgca ccgctccctg 25080
gcctgcaacc cccagctgct gagcgagacc cagatcatcg gcaccttcga gttgcaaggg 25140
cccggcgatg agggttctgc cgccaagggg ggtctgaaac tcaccccggg gctgtggacc 25200
tcggcctact tgcgcaagtt cgtgcccgag gactaccatc ccttcgagat caggttctac 25260
gaggaccaat cccagccgcc caaggccgag ctgtcggcct gcgtcatcac ccagggggcg 25320
atcctggccc aattgcaagc tatccagaaa tcccgccaag aattcttgct gaaaaagggc 25380
cgcggggtct accttgatcc ccagaccggt gaggagctta accccggctt cccccaggat 25440
gccccgagga agcagcaaga agctgaaagt ggagctgccg cccgtggagg atttggagga 25500
agactgggag agcagtcagg cagaggagga ggagatggaa gactgggaca gcactcaggc 25560
agaggacagc ctgcaagaca gtctggaaga cgaggaggag gcagaggagg tggaagaagt 25620
agccgccgcc gccagaccgt cgtcctcggc ggagaaagca agcagcacgg ataccatctc 25680
cgctccgggt cggggtcccg ctcgacccca cagtagatgg gacgagaccg ggcgattccc 25740
gaaccccacc acccagaccg gtaagaagga gcggcaggga tacaagtcct ggcgggggca 25800
caaaaacgcc atcgtctcct gcttgcaagc ttgcgggggc aacatctcat tcacccggcg 25860
ctacctgctc tttcaccgcg gggtgaactt cccccgcaac atcttgcatt actaccgtca 25920
cctccacagc ccctactact tccaagaaga ggcagaaaaa gacaaaacca gcagctagaa 25980
aatccacagc ggcggcggca ggtggactga ggatcgcggc gaacgagccg gcgcagaccc 26040
gggaactgag gaaccggatc tttcccaccc tctatgccat cttccagcag agtcgggggc 26100
aggagcagga actgaaagtc aagaaccgtt ctctgcgctc gctcacccgc agttgtctgt 26160
atcacaagag cgaagaccaa cttcagcgca cgcttgagga cgccgaggct ctcttcaaca 26220
agtactgcgc actcactctt aaagagtagc ccgcgcccgc ccacacacgg aaaaaggcgg 26280
gaattacgtc acctgtgcac ccccacccag caccgctatg agcaaagaaa ttcccacgcc 26340
ttacatgtgg agctaccagc cccagatggg cctggccgcc ggcgccgccc aggactactc 26400
cacccgcatg aattggctca gcgccgggcc cgggatgatc tcacgggtga atgacatccg 26460
cgcccaccga aaccagatac tcctagaaca gtcagcgctc accgccacgc cccgcaatca 26520
cctcaatccg cgtaattggc ccgccgccct agtgtaccag gaaattcccc agcccacgac 26580
cgtactactt ccgcgagacg cccaggccga agtccagctg actaactcag gtgtccagct 26640
ggcgggcggc gccaccctgt gtcgtcacca ccccgctcag ggtataaagc ggctggtgat 26700
ccggggcaga ggcacacagc tcaacgacga ggtggtgagc tcttcactgg gtttgcgacc 26760
tgacggagtc ttccaactcg ccggatcggg aagatcttcc ttcacgcctc gtcaggccgt 26820
gctgactttg gagagttctt cctcgcaacc tcgctcgggc ggcatcggca ctctccagtt 26880
tgtggaggag ttcactccct cggtctactt caaccccttc tccggctccc ccggccacta 26940
tccggacgag ttcatcccga acttcgatgc catcagcgaa tcggtagacg gctacgattg 27000
aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga cacctggacc actgccgccg 27060
ctttcgctgc ttcgctcggg acctcgccga gtttacctac tttgagctgt ccgaggagca 27120
ccctcagggc ccggcccacg gagtgcggat cgtcgtcgaa gggggcctag actcccacct 27180
gcttcgtatc ttcagccagc gcccgatcct ggtccagcgc caacagggca acaccctcct 27240
gaccctttac tgcatctgca accaccccgg cctgcatgaa agtctttgtt gtctgctgtg 27300
tactgagtat aataaaagct gagatcagcg actactccgg actcgattgt gttcctgcat 27360
ccctcaacca gtctctgacc ttcaccggga acgaaacaga gctccatctc cagtgtaagc 27420
cccacaaaaa gtacctcacc tggctgcacc agggctcccc aatcgccgtt gttaaccact 27480
gcaacgacga cggagtcctg ctgaacggcc ccgccaacct tactttttcc acccgcagaa 27540
gcaagctact gctcttccga cccttcctac cagggatcta tcagtgcgtc tcgggaccct 27600
gccatcacac cttccacctg atcccgaata ccacctcttc cccagcgccg ctcctcacta 27660
acaaccaaac taaccaccac caacgctacc gtcgagacct cgttgaatct aataccaccc 27720
acaccggagg tgagctccga ggtcctcagt catctgggat ttattacggt ccctgggagg 27780
tggtggggtt aatagcttta ggcttagtag cgggtgggct tttggctctt tgctacctat 27840
acctcccttg cttttcctac ttagtggtgc tttgttgctg gtttaagaaa tggggaagat 27900
caccctagtg tgcggtgtgc tggtggcggt actttcgatt ttgggtctgg gcagcgcggc 27960
tgtagtgacg gagaaggccg atccctgctt gacttttaac cccgacaaat gccagctgag 28020
ttttcagcca gatggcaatc ggtgcgcggt gttgattaag tgcggatggg aatgccagag 28080
cgtggcgatc cagtataaaa acaagacgcg gaacaatact ctcgcgtcca catggcagcc 28140
cggggacccc gagtggtaca ccgtctctgt ccctggtgct gacggcttcc ttcgcacggt 28200
aaacaacact tttatttttg agcacatgtg caataccgcc atgttcatga gcaggcagta 28260
ccatatgtgg cccccacgga aagagaatat cgtggtcttc tccatcgctt acagcttgtg 28320
cacggtgcta atcaccgcga tcgtgtgcct gagcattcac atgctcatcg ctattcgccc 28380
cagaaataat gctgagaaag agaaacagcc ataacaccat tttttcacac acctttttca 28440
gaccatggcc tctgttacag ccattattta ttttttgggt cttctgggat ttatcaacag 28500
ttttgaccat aaaaacgtaa ctgcttatgt tggttctaac tgtgtactaa ctgggtacca 28560
gtcacaccaa cgggtttcat ggtactggtt tgataaaaaa aacacagctt atacactttg 28620
caaaggtaat cagcggccca cacagcgcag tggtctttat tacagctgca ctaataataa 28680
tatcacacta cttcaagtga ctaaacaata ttctgggaca tactatggaa ccaattttaa 28740
cacggaacag gacacttact atagtgtcaa agtattggat ccaactactc ccagaactac 28800
taccaaacat accacaacta aaaagcccac tatacctaaa accactaaat taacaaccac 28860
aaccagcacc acacttgctg tgacctcaca ggcaactact gaaaacgaat tggttgccct 28920
gttgcagaat ggggagaata atagcagcag tcctctgcct accaccccca gtgagcaaat 28980
tcccagatcc atgattggca ttatcgctgc tgtggtggtg tgtatggtca ttatcatctt 29040
gtgcatgatg tactatgcct gctactacag aaaacacaga ctgaacaaca agctggaccc 29100
ctactgaatt ttgattttta attacaaatt aattgtggtt gatcccacta cacctccacc 29160
caccacaact accacagaca cacaagaacc cactccagag gcagtagcag agttagcaaa 29220
gcagatttat gaagattcct ttgttgctaa tactcccaca cacctcggac cgcaatgtcc 29280
agggttagta gtcagcggca tcgtcggtgt gctttgtggg ttagcagtta taatcatctg 29340
catgttcatt tttgcttgct gctacagaag gcttcaccga cagaaatcag acccactgct 29400
gaacctctat gtttaatttt tgattttcca gagccatgaa ggcacttagc actttagttt 29460
ttttgtcctt gattggcatt gtttttagta atcctattcc tagagttagc tttattaaac 29520
cagttaatgt tactgaaggg agcaatgtga cactggtagg tgtagagggt gctaaaaaca 29580
ccacctggac aaaatatcac cttaatgggt ggaaagatat ctgcaattgg agtgtgacag 29640
tttatacatg cgagggagtt aatcttacca ttgtcaatgc aacctcagct caaaatggta 29700
gaattcaagg gcaaagtgtt agtgattctg aggggtatta tacccaacat acttttatct 29760
atgacattaa ggtcatacca ttgccaacac ccagcccacc tagcactact caaaccacta 29820
catcaactca gcccaccgcc accacaacag cagaggcatt tttgttgctg ccaccatcta 29880
gcagtcccac tgctagtacc aataagcaga ctactaaatt tttgtccact actgaaagcc 29940
acaccacagc taccttgaga gccttctcta gcaccgctaa tcttacctcg ctttcctata 30000
cattaatcag ttctgttact acctctaccc cagcttctct tcccactccc ctgaagcaaa 30060
ccgaaggcgg tttgcaatgg cagatcaccc tactcattgt gatcggggtg gtcatcctag 30120
cgatgctgct ctacttcatc ttctgccgcc gcatccccaa cgcgaaaccg gtctacaagc 30180
ccatcgttat cgggcagccg gagccgcttc aggtggaggg aggtctaagg aatcttctct 30240
tctcttttac agtatggtga tttgaactat gattcctaga cagttcttta tcattggtct 30300
tctctgcgcg ctccaagtct gtgccaccct cgctctggtg gctaatgcga gtccagactg 30360
cattggaccg ttcgcctcct acgtgctctt tgccttcatc acctgcatct gctgctgtag 30420
catagtctgc ctgcttatta ccttcttcca gttcgttgac tgggtctttg tgcgcatcgc 30480
ctacctgcgc caccaccccc agtaccgcga ccaaagagtg gcgcagctgc tcaggctcat 30540
ctgataagca tgcgggcttt gctacttctc atgcttctac tattgctagc tcccctggtc 30600
gccccctttc ccctcaaatc ccccacccag tcccccaaag aggttcgaaa ctgtaaattc 30660
caagaaccct ggaaattcct caaatgctac cagctcaaat cagacatgca ccccagctgg 30720
ataattatca tgggaatcgt gaacatcctt gcctgcacct tcttttcctt tgtgatttac 30780
ccccgctttg actttggttg gaacgcaccc gaggcgctct ggctcccgcc tgatcccgac 30840
acaccaccac agcagcagca aaatcaggca cacgcaccac caccacagcc taggccccaa 30900
tacatgccca tcttaaacta tgaggccgag ccacaacgag ccatgcttcc tgctattagt 30960
tacttcaatc taaccggtgg agatgactga cccactcaac aacactgtca acgacctcct 31020
ggacatggac ggccgcggct cggagcagcg tctcgcccaa ctccgcattc gccagcagca 31080
ggagagagcc gtcaaggagc tgcaggacgc agtggccatc caccagtgca agaaaggcat 31140
cttctgcctg gtgaagcagg ccaagatctc cttcgaggtc acttccaccg accatcgcct 31200
ctcctacgag ctcctgcagc agcgccagaa gttcacctgc ctggtcggag tcaaccccat 31260
cgtcatcacc cagcagtctg gcgataccaa gggttgcatc cactgctcct gcgactcccc 31320
cgagtgcgtt cacaccctga tcaagaccct atgcggcctc cgcgacctcc tccccatgaa 31380
ctaatcaact aaccccttac cccattaccc atccagtaaa aaaaataaag attaaagaga 31440
cgatgatttt gaattgatca ataaagaatc acttacttga aatctgaaac caggtctctg 31500
tccatgtttt ctgtcagcag cacttcgctc ccctcttccc agctctggta ctgcaggccc 31560
cggcgggctg caaacttcct ccacactctg aaggggatgt caaattcctc ctgtccctca 31620
atcttcattt tttatttcta ttagatgtcc aaaaagcgcg cgcgggtgga tgatggcttc 31680
gaccccgtgt atccctacga tgcagacaac gcaccgaccg tgcccttcat caaccctccc 31740
ttcgtctctt cagatggatt ccaagaaaag cccctggggg tgttgtccct taggctggcc 31800
gaccctgtca ccaccaagaa tggggaaatt accctcaagc tgggggaggg ggtggacctt 31860
gacgactcgg gaaaactcat tgcaaacaca gtaaacaagg ccattgcccc tctcagtttt 31920
tccaacaaca ccatttccct taacatggat acccctttat acaccaaaga tggaaaacta 31980
tccttacaag tttctccacc attaagtata ttaaaatcaa caattttgaa tacattagct 32040
ctagcttttg gctcaggttt aggactcagt ggcagcgccc tggcagtaca gttagcctct 32100
ccacttacat ttgatgataa agggaatata aagattaccc taaacagggg attgcatgtt 32160
acaacaggag atgcaattga aagcaacatc agttgggcta aaggtataaa atttgaagat 32220
ggtgccatag ctacaaacat tggtaagggg ctagagttcg gaaccagtag tacagaaaca 32280
ggagttaata atgcttatcc aatccaagtt aaacttggct ctggtctcag ctttgacagc 32340
acaggagcca taatggctgg caataaagac tatgataaat taactttgtg gacaacgcct 32400
gacccatcac caaactgtca aatacttgca gaaaatgatg caaaactaac actttgctta 32460
actaagtgtg acagtcaaat actggccact gtatcagttt tggttgttag aagtggaaac 32520
ttaaacccaa ttactggcac agtaagcagt gctcaagttt ttctacgttt tgatgcaaat 32580
ggtgttcttt taacagaaca ctctacacta aaaaaatact ggggctacaa gcaaggagat 32640
agcatagatg gcactccata caccaatgct gttggtttta tgccaaattc aacagcttat 32700
ccaaagaccc aaagttctac tactaaaaat aatatagtgg gtcaagtata catgaatgga 32760
gatgtttcaa aacccatgct tcttactata actcttaatg gtactgatga caccaccagt 32820
gcatactcaa tgtcattttc atacacctgg actaacggaa gctatatcgg agcaacattt 32880
ggagctaact catacacctt ctcctacata gcccaacaat aatcccaccc tgcatgccaa 32940
cccacctttt ccctctattt ataaatggaa actgaaacaa aaataaagtt caagtgtttt 33000
attgattcaa cagtttttca caggattcga gtagttattt tccctccacc ctcccatctc 33060
atggaataca ctatcctctc cccacgcaca gccttaaaca tctgaatgct attggtaatg 33120
gacatggttt tgatctccac attccacaca gtttcagagc gagacagtct cgggtcggtc 33180
aaggagatga aaccctccgg gcactcctgc atctgcacct cacagttcaa cagctgaggg 33240
ctgtcctcgg tgattggaat cacagttatc tggaataaga gcgatgagaa tcataatccg 33300
caaacgggat cgggcggttg tggcgcatca ggccccgcag cagtcgctgt ctgcgccgct 33360
ccgtcaagct gctactcaag gggtccgggt ccagggactc cctgcgcatg atgccaatgg 33420
ccctgagcat cagtcgcctg gtacggcggg cgcagcagcg gatgcggatc tcactcaggt 33480
cggagcagta cgtgcagcac agcaccacca agttgttcaa cagtccatag ttcaacgtgc 33540
tccagccaaa actcatttgt ggaactatgc tgcccacatg tccatcgtac cagatcctga 33600
tgtaaatcag gtggcgtccc ctccagaaca cactgcccat gtacatgatc tccttgggca 33660
tgtgcaggtt caccacctcc cggtaccaca tcacccgctg gttgaacatg cagccctgga 33720
taattctgcg gaaccagatg gcaagtaccg tcccgcccgc catgcagcgc agggaccccg 33780
ggttctggca atggcagtgg atcacccacc gctcgcgacc gtggatcaac tgggaactaa 33840
acaagtctat gttggcacag cacaggcaca cgctcatgca tgtcttcagc actctcaatt 33900
cctcgggggt caggaccata tcccagggca cagggaactc ttgcaggaca gtgaacccgg 33960
ccgaacaggg caatcctcgc acggaactta cattgtgcat ggacagggta tcgcaatcag 34020
gcagcaccgg atgatcctcc accagagaag cgcggctctc ggtctcctca cagcgaggta 34080
aggtggccgg cggttggtac ggatgatggc gagataacgc taatcgtgtt ctggatcgtg 34140
tcatgatgga gctgtttccg gacattttcg tatttcacaa agcagaacct ggtccgggca 34200
ctgcacaccg ctcgtcggcg acggtctcgg cgcttcgagc gctcaatgtt gaagttatag 34260
aacagccact ccctcagaac gtgcagtatc tcctgagcct cttgggtgat gaaaatccca 34320
tccgccctga tggctctgat tacatcaacc acggtggaat gggccaaacc cagccagatg 34380
atgcaatttt gttgggtttc ggtgacggcg ggggagggaa gaacaggaag aaccatgatt 34440
aactttattc caaacggtct cggaacactt caaaatgcag gtcccggagg tggcacctct 34500
cgcccccact gtgttggtgg aaaataacag ccaggtcaaa ggtaacacgg ttctcgagat 34560
gttccacggt ggcttccagc aaagcctcca cgcgcacatc cagaaacaag aggacagcga 34620
aagcgggagc gttttctaat tcctcaatca tcatattaca ctcctgcacc atgcctagat 34680
aattttcatt tttccagcct tgaatgattc gtattagttc ctgaggtaaa tccaagccag 34740
ccatgataaa aagctcgcgc agagcgccct ccaccggcat tcttaagcac accctcataa 34800
ttccaacaga ttctgctcct ggttcacctg tagtagatta acaagtggaa tatcaattgc 34860
tctgccgcaa tccctaagct cctcccttag cagtaactgt atgtactcat tcatatcttc 34920
tccgaaattt ttagccatag gaccaccagg aacaagagaa gggcaagcca cattacagat 34980
aaagcgaagt cctccccagt gagcattgcc aaatgtaaga ttgaaataag catgctggct 35040
agacccggtg atatcttcca gataactgga cagaaaatca ggcaagcaat ttttaagaaa 35100
attaacaaaa gaaaagtcgt ctaggtgcac gtttagagcc tcaggaacaa cgatggaata 35160
agtgcaagga gtacgttcca gcatggttag tgtttttggt gatctgtaga acaaaaaata 35220
aacatgcaat attaaaccat gctagcctgg cgaacaggtg gataaatcac tctttccaac 35280
accaggcagg ctacagggtc tccggcgcga ccattgtaga agctgacatt atgattaaaa 35340
agcatcaccg acagaccttc ccggtggccg gcatggatga ttcgagaaga agcatacact 35400
ccgggaacat tggcgtccgt gagtgaaaaa aagcgaccta taaagccttg aggcactaca 35460
atgcttaatc ttaattccag caaagcgacc ccatgcggat gaagcacaaa attggcaggt 35520
gcgtaaaaaa tgtaattact ccccttctgc acaggcagca aagcccccgc tccctccaga 35580
aacacataca aaacctgagc gtccatagct taccgagcac ggcaggcgca agagtcagag 35640
aaaaagctga gctctaacct aactgcccgc ttctgtactc aatatatagc cctaacctca 35700
ctgacgtaaa ggccaaggtc taaaaatacc cgccaacacg cccagaaacc ggtgacacac 35760
taaaaaaata cgtgcacttc ctcaaacgcc caaactggcg tcatttccgg tttcccacgc 35820
tacgtcacct ctcaacgact ttcaaattcc gtcgaccgtt aaacacatca gttaccccgc 35880
ccctaacgaa cgccgctgtc acagccaatc agcgcgcccc atccccaaat tttcacgcct 35940
tatttgcata ttaactcaca caaaaaaaat aaggtatatt atatagatag cctccggggt 36000
ccactgcaat tacttctcga ccaattctca tgtttgacag cttatcatcg aatttctgcc 36060
attcatccgc ttattatcac ttattcaggc gtagcaacca ggcgtttaag ggcaccaata 36120
actgccttaa aaaaattacg ccccgccctg ccactcatcg cagtactgtt gtaattcatt 36180
aagcattctg ccgacatgga agccatcaca gacggcatga tgaacctgaa tcgccagcgg 36240
catcagcacc ttgtcgcctt gcgtataata tttgcccatg gtgaaaacgg gggcgaagaa 36300
gttgtccata ttggccacgt ttaaatcaaa actggtgaaa ctcacccagg gattggctga 36360
gacgaaaaac atattctcaa taaacccttt agggaaatag gccaggtttt caccgtaaca 36420
cgccacatct tgcgaatata tgtgtagaaa ctgccggaaa tcgtcgtggt attcactcca 36480
gagcgatgaa aacgtttcag tttgctcatg gaaaacggtg taacaagggt gaacactatc 36540
ccatatcacc agctcaccgt ctttcattgc catacggaat tccggatgag cattcatcag 36600
gcgggcaaga atgtgaataa aggccggata aaacttgtgc ttatttttct ttacggtctt 36660
taaaaaggcc gtaatatcca gctgaacggt ctggttatag gtacattgag caactgactg 36720
aaatgcctca aaatgttctt tacgatgcca ttgggatata tcaacggtgg tatatccagt 36780
gatttttttc tccattttag cttccttagc tcctgaaaat ctcgataact caaaaaatac 36840
gcccggtagt gatcttattt cattatggtg aaagttggaa cctcttacgt gccgatcaac 36900
gtctcatttt cgccaaaagt tggcccaggg cttcccggta tcaacaggga caccaggatt 36960
tatttattct gcgaagtgat cttccgtcac aggtatttat tcgcgataag ctcatggagc 37020
ggcgtaaccg tcgcacagga aggacagaga aagcgcggat ctgggaagtg acggacagaa 37080
cggtcaggac ctggattggg gaggcggttg ccgccgctgc tgctgacggt gtgacgttct 37140
ctgttccggt cacaccacat acgttccgcc attcctatgc gatgcacatg ctgtatgccg 37200
gtataccgct gaaagttctg caaagcctga tgggacataa gtccatcagt tcaacggaag 37260
tctacacgaa ggtttttgcg ctggatgtgg ctgcccggca ccgggtgcag tttgcgatgc 37320
cggagtctga tgcggttgcg atgctgaaac aattatcctg agaataaatg ccttggcctt 37380
tatatggaaa tgtggaactg agtggatatg ctgtttttgt ctgttaaaca gagaagctgg 37440
ctgttatcca ctgagaagcg aacgaaacag tcgggaaaat ctcccattat cgtagagatc 37500
cgcattatta atctcaggag cctgtgtagc gtttatagga agtagtgttc tgtcatgatg 37560
cctgcaagcg gtaacgaaaa cgatttgaat atgccttcag gaacaataga aatcttcgtg 37620
cggtgttacg ttgaagtgga gcggattatg tcagcaatgg acagaacaac ctaatgaaca 37680
cagaaccatg atgtggtctg tccttttaca gccagtaggc tcgccgcagt cgagcgacgg 37740
cgaagccctc gagtgagcga ggaagcacca gggaacagca cttatatatt ctgcttacac 37800
acgatgcctg aaaaaacttc ccttggggtt atccacttat ccacggggat atttttataa 37860
ttattttttt tatagttttt agatcttctt ttttagagcg ccttgtaggc ctttatccat 37920
gctggttcta gagaaggtgt tgtgacaaat tgccctttca gtgtgacaaa tcaccctcaa 37980
atgacagtcc tgtctgtgac aaattgccct taaccctgtg acaaattgcc ctcagaagaa 38040
gctgtttttt cacaaagtta tccctgctta ttgactcttt tttatttagt gtgacaatct 38100
aaaaacttgt cacacttcac atggatctgt catggcggaa acagcggtta tcaatcacaa 38160
gaaacgtaaa aatagcccgc gaatcgtcca gtcaaacgac ctcactgagg cggcatatag 38220
tctctcccgg gatcaaaaac gtatgctgta tctgttcgtt gaccagatca gaaaatctga 38280
tggcacccta caggaacatg acggtatctg cgagatccat gttgctaaat atgctgaaat 38340
attcggattg acctctgcgg aagccagtaa ggatatacgg caggcattga agagtttcgc 38400
ggggaaggaa gtggtttttt atcgccctga agaggatgcc ggcgatgaaa aaggctatga 38460
atcttttcct tggtttatca aacgtgcgca cagtccatcc agagggcttt acagtgtaca 38520
tatcaaccca tatctcattc ccttctttat cgggttacag aaccggttta cgcagtttcg 38580
gcttagtgaa acaaaagaaa tcaccaatcc gtatgccatg cgtttatacg aatccctgtg 38640
tcagtatcgt aagccggatg gctcaggcat cgtctctctg aaaatcgact ggatcataga 38700
gcgttaccag ctgcctcaaa gttaccagcg tatgcctgac ttccgccgcc gcttcctgca 38760
ggtctgtgtt aatgagatca acagcagaac tccaatgcgc ctctcataca ttgagaaaaa 38820
gaaaggccgc cagacgactc atatcgtatt ttccttccgc gatatcactt ccatgacgac 38880
aggatagtct gagggttatc tgtcacagat ttgagggtgg ttcgtcacat ttgttctgac 38940
ctactgaggg taatttgtca cagttttgct gtttccttca gcctgcatgg attttctcat 39000
actttttgaa ctgtaatttt taaggaagcc aaatttgagg gcagtttgtc acagttgatt 39060
tccttctctt tcccttcgtc atgtgacctg atatcggggg ttagttcgtc atcattgatg 39120
agggttgatt atcacagttt attactctga attggctatc cgcgtgtgta cctctacctg 39180
gagtttttcc cacggtggat atttcttctt gcgctgagcg taagagctat ctgacagaac 39240
agttcttctt tgcttcctcg ccagttcgct cgctatgctc ggttacacgg ctgcggcgag 39300
cgctagtgat aataagtgac tgaggtatgt gctcttctta tctccttttg tagtgttgct 39360
cttattttaa acaactttgc ggttttttga tgactttgcg attttgttgt tgctttgcag 39420
taaattgcaa gatttaataa aaaaacgcaa agcaatgatt aaaggatgtt cagaatgaaa 39480
ctcatggaaa cacttaacca gtgcataaac gctggtcatg aaatgacgaa ggctatcgcc 39540
attgcacagt ttaatgatga cagcccggaa gcgaggaaaa taacccggcg ctggagaata 39600
ggtgaagcag cggatttagt tggggtttct tctcaggcta tcagagatgc cgagaaagca 39660
gggcgactac cgcacccgga tatggaaatt cgaggacggg ttgagcaacg tgttggttat 39720
acaattgaac aaattaatca tatgcgtgat gtgtttggta cgcgattgcg acgtgctgaa 39780
gacgtatttc caccggtgat cggggttgct gcccataaag gtggcgttta caaaacctca 39840
gtttctgttc atcttgctca ggatctggct ctgaaggggc tacgtgtttt gctcgtggaa 39900
ggtaacgacc cccagggaac agcctcaatg tatcacggat gggtaccaga tcttcatatt 39960
catgcagaag acactctcct gcctttctat cttggggaaa aggacgatgt cacttatgca 40020
ataaagccca cttgctggcc ggggcttgac attattcctt cctgtctggc tctgcaccgt 40080
attgaaactg agttaatggg caaatttgat gaaggtaaac tgcccaccga tccacacctg 40140
atgctccgac tggccattga aactgttgct catgactatg atgtcatagt tattgacagc 40200
gcgcctaacc tgggtatcgg cacgattaat gtcgtatgtg ctgctgatgt gctgattgtt 40260
cccacgcctg ctgagttgtt tgactacacc tccgcactgc agtttttcga tatgcttcgt 40320
gatctgctca agaacgttga tcttaaaggg ttcgagcctg atgtacgtat tttgcttacc 40380
aaatacagca atagtaatgg ctctcagtcc ccgtggatgg aggagcaaat tcgggatgcc 40440
tggggaagca tggttctaaa aaatgttgta cgtgaaacgg atgaagttgg taaaggtcag 40500
atccggatga gaactgtttt tgaacaggcc attgatcaac gctcttcaac tggtgcctgg 40560
agaaatgctc tttctatttg ggaacctgtc tgcaatgaaa ttttcgatcg tctgattaaa 40620
ccacgctggg agattagata atgaagcgtg cgcctgttat tccaaaacat acgctcaata 40680
ctcaaccggt tgaagatact tcgttatcga caccagctgc cccgatggtg gattcgttaa 40740
ttgcgcgcgt aggagtaatg gctcgcggta atgccattac tttgcctgta tgtggtcggg 40800
atgtgaagtt tactcttgaa gtgctccggg gtgatagtgt tgagaagacc tctcgggtat 40860
ggtcaggtaa tgaacgtgac caggagctgc ttactgagga cgcactggat gatctcatcc 40920
cttcttttct actgactggt caacagacac cggcgttcgg tcgaagagta tctggtgtca 40980
tagaaattgc cgatgggagt cgccgtcgta aagctgctgc acttaccgaa agtgattatc 41040
gtgttctggt tggcgagctg gatgatgagc agatggctgc attatccaga ttgggtaacg 41100
attatcgccc aacaagtgct tatgaacgtg gtcagcgtta tgcaagccga ttgcagaatg 41160
aatttgctgg aaatatttct gcgctggctg atgcggaaaa tatttcacgt aagattatta 41220
cccgctgtat caacaccgcc aaattgccta aatcagttgt tgctcttttt tctcaccccg 41280
gtgaactatc tgcccggtca ggtgatgcac ttcaaaaagc ctttacagat aaagaggaat 41340
tacttaagca gcaggcatct aaccttcatg agcagaaaaa agctggggtg atatttgaag 41400
ctgaagaagt tatcactctt ttaacttctg tgcttaaaac gtcatctgca tcaagaacta 41460
gtttaagctc acgacatcag tttgctcctg gagcgacagt attgtataag ggcgataaaa 41520
tggtgcttaa cctggacagg tctcgtgttc caactgagtg tatagagaaa attgaggcca 41580
ttcttaagga acttgaaaag ccagcaccct gatgcgacca cgttttagtc tacgtttatc 41640
tgtctttact taatgtcctt tgttacaggc cagaaagcat aactggcctg aatattctct 41700
ctgggcccac tgttccactt gtatcgtcgg tctgataatc agactgggac cacggtccca 41760
ctcgtatcgt cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg 41820
attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgataatca gactgggacc 41880
acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accatggtcc cactcgtatc 41940
gtcggtctga ttattagtct gggaccacgg tcccactcgt atcgtcggtc tgattattag 42000
tctggaacca cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacggtccc 42060
actcgtatcg tcggtctgat tattagtctg ggaccacgat cccactcgtg ttgtcggtct 42120
gattatcggt ctgggaccac ggtcccactt gtattgtcga tcagactatc agcgtgagac 42180
tacgattcca tcaatgcctg tcaagggcaa gtattgacat gtcgtcgtaa cctgtagaac 42240
ggagtaacct cggtgtgcgg ttgtatgcct gctgtggatt gctgctgtgt cctgcttatc 42300
cacaacattt tgcgcacggt tatgtggaca aaatacctgg ttacccaggc cgtgccggca 42360
cgttaaccgg gctgcatccg atgcaagtgt gtcgctgtcg agtttataat tgcagtggac 42420
cccggagg 42428
<210> 43
<211> 42957
<212> DNA
<213> 人工序列
<220>
<223> pBWH-SE25
<400> 43
ccacggtccc actcgtatcg tcggtctgat tattagtctg ggaccacggt cccactcgta 60
tcgtcggtct gataatcaga ctgggaccac ggtcccactc gtatcgtcgg tctgattatt 120
agtctgggac catggtccca ctcgtatcgt cggtctgatt attagtctgg gaccacggtc 180
ccactcgtat cgtcggtctg attattagtc tggaaccacg gtcccactcg tatcgtcggt 240
ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgatta ttagtctggg 300
accacgatcc cactcgtgtt gtcggtctga ttatcggtct gggaccacgg tcccacttgt 360
attgtcgatc agactatcag cgtgagacta cgattccatc aatgcctgtc aagggcaagt 420
attgacatgt cgtcgtaacc tgtagaacgg agtaacctcg gtgtgcggtt gtatgcctgc 480
tgtggattgc tgctgtgtcc tgcttatcca caacattttg cgcacggtta tgtggacaaa 540
atacctggtt acccaggccg tgccggcacg ttaaccgggc tgcatccgat gcaagtgtgt 600
cgctgtcgag tttataattg cagtggaccc cggaggccat cttcaataat atacctcaaa 660
ctttttgtgc gcgttaatat gcaaatgagg cgtttgaatt tggggaggaa gggcggtgat 720
tggtcgaggg atgagcgacc gttaggggcg gggcgagtga cgttttgatg acgtggttgc 780
gaggaggagc cagtttgcaa gttctcgtgg gaaaagtgac gtcaaacgag gtgtggtttg 840
aacacggaaa tactcaattt tcccgcgctc tctgacagga aatgaggtgt ttctgggcgg 900
atgcaagtga aaacgggcca ttttcgcgcg aaaactgaat gaggaagtga aaatctgagt 960
aatttcgcgt ttatggcagg gaggagtatt tgccgagggc cgagtagact ttgaccgatt 1020
acgtgggggt ttcgattacc gtgtttttca cctaaatttc cgcgtacggt gtcaaagtcc 1080
ggtgttttta cgtaggtgtc agctgatcgc cagggtattt aaacctgcgc tctccagtca 1140
agaggccact cttgagtgcc agcgagaaga gttttctcct ccgcgccgcg agtcagatct 1200
acactttgaa agatgaggca cctgagagac ctgcccgatg agaaaatcat catcgcttcc 1260
gggaacgaga ttctggaact ggtggtaaat gccatgatgg gcgacgaccc tccggagccc 1320
cccaccccat ttgagacacc ttcgctgcac gatttgtatg atctggaggt ggatgtgccc 1380
gaggacgatc ccaatgagga ggcggtaaat gattttttta gcgatgccgc gctgctagct 1440
gccgaggagg cttcgagctc tagctcagac agcgactctt cactgcatac ccctagaccc 1500
ggcagaggtg agaaaaagat ccccgagctt aaaggggaag agatggactt gcgctgctat 1560
gaggaatgct tgcccccgag cgatgatgag gacgagcagg cgatccagaa cgcagcgagc 1620
cagggagtgc aagccgccag cgagagcttt gcgctggact gcccgcctct gcccggacac 1680
ggctgtaagt cttgtgaatt tcatcgcatg aatactggag ataaagctgt gttgtgtgca 1740
ctttgctata tgagagctta caaccattgt gtttacagta agtgtgatta agttgaactt 1800
tagagggagg cagagagcag ggtgactggg cgatgactgg tttatttatg tatatatgtt 1860
ctttatatag gtcccgtctc tgacgcagat gatgagaccc ccactacaaa gtccacttcg 1920
tcacccccag aaattggcac atctccacct gagaatattg ttagaccagt tcctgttaga 1980
gccactggga ggagagcagc tgtggaatgt ttggatgact tgctacaggg tggggttgaa 2040
cctttggact tgtgtacccg gaaacgcccc aggcactaag tgccacacat gtgtgtttac 2100
ttgaggtgat gtcagtattt atagggtgtg gagtgcaata aaaaatgtgt tgactttaag 2160
tgcgtggttt atgactcagg ggtggggact gtgagtatat aagcaggtgc agacctgtgt 2220
ggttagctca gagcggcatg gagatttgga cggtcttgga agactttcac aagactagac 2280
agctgctaga gaacgcctcg aacggagtct cttacctgtg gagattctgc ttcggtggcg 2340
acctagctag gctagtctac agggccaaac aggattatag tgaacaattt gaggttattt 2400
tgagagagtg ttctggtctt tttgacgctc ttaacttggg ccatcagtct cactttaacc 2460
agaggatttc gagagccctt gattttacta ctcctggcag aaccactgca gcagtagcct 2520
tttttgcttt tattcttgac aaatggagtc aagaaaccca tttcagcagg gattaccagc 2580
tggatttctt agcagtagct ttgtggagaa catggaagtg ccagcgcctg aatgcaatct 2640
ccggctactt gccggtacag ccgctagaca ctctgaggat cctgaatctc caggagagtc 2700
ccagggcacg ccaacgtcgc cagcagcagc agcaggagga ggatcaagaa gagaacccga 2760
gagccggcct ggaccctccg gcggaggagg aggagtagct gacctgtttc ctgaactgcg 2820
ccgggtgctg actaggtctt cgagtggtcg ggagaggggg attaagcggg agaggcatga 2880
tgagactaat cacagaactg aactgactgt gggtctgatg agtcgcaagc gcccagaaac 2940
agtgtggtgg catgaggtgc agtcgactgg cacagatgag gtgtcggtga tgcatgagag 3000
gttttctcta gaacaagtca agacttgttg gttagagcct gaggatgatt gggaggtagc 3060
catcaggaat tatgccaagc tggctctgag gccagacaag aagtacaaga ttactaagct 3120
gataaatatc agaaatgcct gctacatctc agggaatggg gctgaagtgg agatctgtct 3180
ccaggaaagg gtggctttca gatgctgcat gatgaatatg tacccgggag tggtgggcat 3240
ggatggggtt acctttatga acatgaggtt caggggagat gggtataatg gcacggtctt 3300
tatggccaat accaagctga cagtccatgg ctgctccttc tttgggttta ataacacctg 3360
catcgaggcc tggggtcagg tcggtgtgag gggctgcagt ttttcagcca actggatggg 3420
ggtcgtgggc aggaccaaga gtatgctgtc cgtgaagaaa tgcttgtttg agaggtgcca 3480
cctgggggtg atgagcgagg gcgaagccag aatccgccac tgcgcctcta ccgagacggg 3540
ctgctttgtg ctgtgcaagg gcaatgctaa gatcaagcat aatatgatct gtggagcctc 3600
ggacgagcgc ggctaccaga tgctgacctg cgccggcggg aacagccata tgctggccac 3660
cgtacatgtg gcttcccatg ctcgcaagcc ctggcccgag ttcgagcaca atgtcatgac 3720
caggtgcaat atgcatctgg ggtcccgccg aggcatgttc atgccctacc agtgcaacct 3780
gaattatgtg aaggtgctgc tggagcccga tgccatgtcc agagtgagcc tgacgggggt 3840
gtttgacatg aatgtggagg tgtggaagat tctgagatat gatgaatcca agaccaggtg 3900
ccgagcctgc gagtgcggag ggaagcatgc caggttccag cccgtgtgtg tggatgtgac 3960
ggaggacctg cgacccgatc atttggtgtt gccctgcacc gggacggagt tcggttccag 4020
cggggaagaa tctgactaga gtgagtagtg ttctggggcg ggggaggacc tgcatgaggg 4080
ccagaataac tgaaatctgt gcttttctgt gtgttgcagc agcatgagcg gaagcggctc 4140
ctttgaggga ggggtattca gcccttatct gacggggcgt ctcccctcct gggcgggagt 4200
gcgtcagaat gtgatgggat ccacggtgga cggccggccc gtgcagcccg cgaactcttc 4260
aaccctgacc tatgcaaccc tgagctcttc gtcgttggac gcagctgccg ccgcagctgc 4320
tgcatctgcc gccagcgccg tgcgcggaat ggccatgggc gccggctact acggcactct 4380
ggtggccaac tcgagttcca ccaataatcc cgccagcctg aacgaggaga agctgttgct 4440
gctgatggcc cagctcgagg ccttgaccca gcgcctgggc gagctgaccc agcaggtggc 4500
tcagctgcag gagcagacgc gggccgcggt tgccacggtg aaatccaaat aaaaaatgaa 4560
tcaataaata aacggagacg gttgttgatt ttaacacaga gtctgaatct ttatttgatt 4620
tttcgcgcgc ggtaggccct ggaccaccgg tctcgatcat tgagcacccg gtggatcttt 4680
tccaggaccc ggtagaggtg ggcttggatg ttgaggtaca tgggcatgag cccgtcccgg 4740
gggtggaggt agctccattg cagggcctcg tgctcggggg tggtgttgta aatcacccag 4800
tcatagcagg ggcgcagggc atggtgttgc acaatatctt tgaggaggag actgatggcc 4860
acgggcagcc ctttggtgta ggtgtttaca aatctgttga gctgggaggg atgcatgcgg 4920
ggggagatga ggtgcatctt ggcctggatc ttgagattgg cgatgttacc gcccagatcc 4980
cgcctggggt tcatgttgtg caggaccacc agcacggtgt atccggtgca cttggggaat 5040
ttatcatgca acttggaagg gaaggcgtga aagaatttgg cgacgccttt gtgcccgccc 5100
aggttttcca tgcactcatc catgatgatg gcgatgggcc cgtgggcggc ggcctgggca 5160
aagacgtttc gggggtcgga cacatcatag ttgtggtcct gggtgaggtc atcataggcc 5220
attttaatga atttggggcg gagggtgccg gactggggga caaaggtacc ctcgatcccg 5280
ggggcgtagt tcccctcaca gatctgcatc tcccaggctt tgagctcgga gggggggatc 5340
atgtccacct gcggggcgat aaagaacacg gtttccgggg cgggggagat gagctgggcc 5400
gaaagcaagt tccggagcag ctgggacttg ccgcagccgg tggggccgta gatgaccccg 5460
atgaccggct gcaggtggta gttgagggag agacagctgc cgtcctcccg gaggaggggg 5520
gccacctcgt tcatcatctc gcgcacgtgc atgttctcgc gcaccagttc cgccaggagg 5580
cgctctcccc ccagggatag gagctcctgg agcgaggcga agtttttcag cggcttgagt 5640
ccgtcggcca tgggcatttt ggagagggtt tgttgcaaga gttccaggcg gtcccagagc 5700
tcggtgatgt gctctacggc atctcgatcc agcagacctc ctcgtttcgc gggttgggac 5760
ggctgcggga gtagggcacc agacgatggg cgtccagcgc agccagggtc cggtccttcc 5820
agggtcgcag cgtccgcgtc agggtggtct ccgtcacggt gaaggggtgc gcgccgggct 5880
gggcgcttgc gagggtgcgc ttcaggctca tccggctggt cgaaaaccgc tcccgatcgg 5940
cgccctgcgc gtcggccagg tagcaattga ccatgagttc gtagttgagc gcctcggccg 6000
cgtggccttt ggcgcggagc ttacctttgg aagtctgccc gcaggcggga cagaggaggg 6060
acttgagggc gtagagcttg ggggcgagga agacggactc gggggcgtag gcgtccgcgc 6120
cgcagtgggc gcagacggtc tcgcactcca cgagccaggt gaggtcgggc tggtcggggt 6180
caaaaaccag tttcccgccg ttctttttga tgcgtttctt acctttggtc tccatgagct 6240
cgtgtccccg ctgggtgaca aagaggctgt ccgtgtcccc gtagaccgac tttatgggcc 6300
ggtcctcgag cggtgtgccg cggtcctcct cgtagaggaa ccccgcccac tccgagacga 6360
aagcccgggt ccaggccagc acgaaggagg ccacgtggga cgggtagcgg tcgttgtcca 6420
ccagcgggtc caccttttcc agggtatgca aacacatgtc cccctcgtcc acatccagga 6480
aggtgattgg cttgtaagtg taggccacgt gaccgggggt cccggccggg ggggtataaa 6540
agggtgcggg tccctgctcg tcctcactgt cttccggatc gctgtccagg agcgccagct 6600
gttggggtag gtattccctc tcgaaggcgg gcatgacctc ggcactcagg ttgtcagttt 6660
ctagaaacga ggaggatttg atattgacgg tgccggcgga gatgcctttc aagagcccct 6720
cgtccatctg gtcagaaaag acgatctttt tgttgtcgag cttggtggcg aaggagccgt 6780
agagggcgtt ggagaggagc ttggcgatgg agcgcatggt ctggtttttt tccttgtcgg 6840
cgcgctcctt ggcggcgatg ttgagctgca cgtactcgcg cgccacgcac ttccattcgg 6900
ggaagacggt ggtcagctcg tcgggcacga ttctgacctg ccagccccga ttatgcaggg 6960
tgatgaggtc cacactggtg gccacctcgc cgcgcagggg ctcattagtc cagcagaggc 7020
gtccgccctt gcgcgagcag aaggggggca gggggtccag catgacctcg tcgggggggt 7080
cggcatcgat ggtgaagatg ccgggcagga ggtcggggtc aaagtagctg atggaagtgg 7140
ccagatcgtc cagggcagct tgccattcgc gcacggccag cgcgcgctcg tagggactga 7200
ggggcgtgcc ccagggcatg ggatgggtaa gcgcggaggc gtacatgccg cagatgtcgt 7260
agacgtagag gggctcctcg aggatgccga tgtaggtggg gtagcagcgc cccccgcgga 7320
tgctggcgcg cacgtagtca tacagctcgt gcgagggggc gaggagcccc gggcccaggt 7380
tggtgcgact gggcttttcg gcgcggtaga cgatctggcg gaaaatggca tgcgagttgg 7440
aggagatggt gggcctttgg aagatgttga agtgggcgtg gggcagtccg accgagtcgc 7500
ggatgaagtg ggcgtaggag tcttgcagct tggcgacgag ctcggcggtg actaggacgt 7560
ccagagcgca gtagtcgagg gtctcctgga tgatgtcata cttgagctgt cccttttgtt 7620
tccacagctc gcggttgaga aggaactctt cgcggtcctt ccagtactct tcgaggggga 7680
acccgtcctg atctgcacgg taagagccta gcatgtagaa ctggttgacg gccttgtagg 7740
cgcagcagcc cttctccacg gggagggcgt aggcctgggc ggccttgcgc agggaggtgt 7800
gcgtgagggc gaaagtgtcc ctgaccatga ccttgaggaa ctggtgcttg aagtcgatat 7860
cgtcgcagcc cccctgctcc cagagctgga agtccgtgcg cttcttgtag gcggggttgg 7920
gcaaagcgaa agtaacatcg ttgaagagga tcttgcccgc gcggggcata aagttgcgag 7980
tgatgcggaa aggttggggc acctcggccc ggttgttgat gacctgggcg gcgagcacga 8040
tctcgtcgaa gccgttgatg ttgtggccca cgatgtagag ttccacgaat cgcggacggc 8100
ccttgacgtg gggcagtttc ttgagctcct cgtaggtgag ctcgtcgggg tcgctgagcc 8160
cgtgctgctc gagcgcccag tcggcgagat gggggttggc gcggaggaag gaagtccaga 8220
gatccacggc cagggcggtt tgcagacggt cccggtactg acggaactgc tgcccgacgg 8280
ccattttttc gggggtgacg cagtagaagg tgcgggggtc cccgtgccag cgatcccatt 8340
tgagctggag ggcgagatcg agggcgagct cgacgagccg gtcgtccccg gagagtttca 8400
tgaccagcat gaaggggacg agctgcttgc cgaaggaccc catccaggtg taggtttcca 8460
catcgtaggt gaggaagagc ctttcggtgc gaggatgcga gccgatgggg aagaactgga 8520
tctcctgcca ccaattggag gaatggctgt tgatgtgatg gaagtagaaa tgccgacggc 8580
gcgccgaaca ctcgtgcttg tgtttataca agcggccaca gtgctcgcaa cgctgcacgg 8640
gatgcacgtg ctgcacgagc tgtacctgag ttcctttgac gaggaatttc agtgggaagt 8700
ggagtcgtgg cgcctgcatc tcgtgctgta ctacgtcgtg gtggtcggcc tggccctctt 8760
ctgcctcgat ggtggtcatg ctgacgagcc cgcgcgggag gcaggtccag acctcggcgc 8820
gagcgggtcg gagagcgagg acgagggcgc gcaggccgga gctgtccagg gtcctgagac 8880
gctgcggagt caggtcagtg ggcagcggcg gcgcgcggtt gacttgcagg agtttttcca 8940
gggcgcgcgg gaggtccaga tggtacttga tctccaccgc gccattggtg gcgacgtcga 9000
tggcttgcag ggtcccgtgc ccctggggtg tgaccaccgt cccccgtttc ttcttgggcg 9060
gctggggcga cgggggcggt gcctcttcca tggttagaag cggcggcgag gacgcgcgcc 9120
gggcggcagg ggcggctcgg ggcccggagg caggggcggc aggggcacgt cggcgccgcg 9180
cgcgggtagg ttctggtact gcgcccggag aagactggcg tgagcgacga cgcgacggtt 9240
gacgtcctgg atctgacgcc tctgggtgaa ggccacggga cccgtgagtt tgaacctgaa 9300
agagagttcg acagaatcaa tctcggtatc gttgacggcg gcctgccgca ggatctcttg 9360
cacgtcgccc gagttgtcct ggtaggcgat ctcggtcatg aactgctcga tctcctcctc 9420
ttgaaggtct ccgcggccgg cgcgctccac ggtggccgcg aggtcgttgg agatgcggcc 9480
catgagctgc gagaaggcgt tcatgcccgc ctcgttccag acgcggctgt agaccacgac 9540
gccctcggga tcgccggcgc gcatgaccac ctgggcgagg ttgagctcca cgtggcgcgt 9600
gaagaccgcg tagttgcaga ggcgctggta gaggtagttg agcgtggtgg cgatgtgctc 9660
ggtgacgaag aaatacatga tccagcggcg gagcggcatc tcgctgacgt cgcccagcgc 9720
ctccaaacgt tccatggcct cgtaaaagtc cacggcgaag ttgaaaaact gggagttgcg 9780
cgccgagacg gtcaactcct cctccagaag acggatgagc tcggcgatgg tggcgcgcac 9840
ctcgcgctcg aaggcccccg ggagttcctc cacttcctct tcttcctcct ccactaacat 9900
ctcttctact tcctcctcag gcggcagtgg tggcggggga gggggcctgc gtcgccggcg 9960
gcgcacgggc agacggtcga tgaagcgctc gatggtctcg ccgcgccggc gtcgcatggt 10020
ctcggtgacg gcgcgcccgt cctcgcgggg ccgcagcgtg aagacgccgc cgcgcatctc 10080
caggtggccg ggggggtccc cgttgggcag ggagagggcg ctgacgatgc atcttatcaa 10140
ttgccccgta gggactccgc gcaaggacct gagcgtctcg agatccacgg gatctgaaaa 10200
ccgctgaacg aaggcttcga gccagtcgca gtcgcaaggt aggctgagca cggtttcttc 10260
tggcgggtca tgttggttgg gagcggggcg ggcgatgctg ctggtgatga agttgaaata 10320
ggcggttctg agacggcgga tggtggcgag gagcaccagg tctttgggcc cggcttgctg 10380
gatgcgcaga cggtcggcca tgccccaggc gtggtcctga cacctggcca ggtccttgta 10440
gtagtcctgc atgagccgct ccacgggcac ctcctcctcg cccgcgcggc cgtgcatgcg 10500
cgtgagcccg aagccgcgct ggggctggac gagcgccagg tcggcgacga cgcgctcggc 10560
gaggatggct tgctggatct gggtgagggt ggtctggaag tcatcaaagt cgacgaagcg 10620
gtggtaggct ccggtgttga tggtgtagga gcagttggcc atgacggacc agttgacggt 10680
ctggtggccc ggacgcacga gctcgtggta cttgaggcgc gagtaggcgc gcgtgtcgaa 10740
gatgtagtcg ttgcaggtgc gcaccaggta ctggtagccg atgaggaagt gcggcggcgg 10800
ctggcggtag agcggccatc gctcggtggc gggggcgccg ggcgcgaggt cctcgagcat 10860
ggtgcggtgg tagccgtaga tgtacctgga catccaggtg atgccggcgg cggtggtgga 10920
ggcgcgcggg aactcgcgga cgcggttcca gatgttgcgc agcggcagga agtagttcat 10980
ggtgggcacg gtctggcccg tgaggcgcgc gcagtcgtgg atgctctata cgggcaaaaa 11040
cgaaagcggt cagcggctcg actccgtggc ctggaggcta agcgaacggg ttgggctgcg 11100
cgtgtacccc ggttcgaatc tcgaatcagg ctggagccgc agctaacgtg gtattggcac 11160
tcccgtctcg acccaagcct gcaccaaccc tccaggatac ggaggcgggt cgttttgcaa 11220
cttttttttg gaggccggat gagactagta agcgcggaaa gcggccgacc gcgatggctc 11280
gctgccgtag tctggagaag aatcgccagg gttgcgttgc ggtgtgcccc ggttcgaggc 11340
cggccggatt ccgcggctaa cgagggcgtg gctgccccgt cgtttccaag accccatagc 11400
cagccgactt ctccagttac ggagcgagcc cctcttttgt tttgtttgtt tttgccagat 11460
gcatcccgta ctgcggcaga tgcgccccca ccaccctcca ccgcaacaac agccccctcc 11520
acagccggcg cttctgcccc cgccccagca gcaacttcca gccacgaccg ccgcggccgc 11580
cgtgagcggg gctggacaga gttatgatca ccagctggcc ttggaagagg gcgaggggct 11640
ggcgcgcctg ggggcgtcgt cgccggagcg gcacccgcgc gtgcagatga aaagggacgc 11700
tcgcgaggcc tacgtgccca agcagaacct gttcagagac aggagcggcg aggagcccga 11760
ggagatgcgc gcggcccggt tccacgcggg gcgggagctg cggcgcggcc tggaccgaaa 11820
gagggtgctg agggacgagg atttcgaggc ggacgagctg acggggatca gccccgcgcg 11880
cgcgcacgtg gccgcggcca acctggtcac ggcgtacgag cagaccgtga aggaggagag 11940
caacttccaa aaatccttca acaaccacgt gcgcaccctg atcgcgcgcg aggaggtgac 12000
cctgggcctg atgcacctgt gggacctgct ggaggccatc gtgcagaacc ccaccagcaa 12060
gccgctgacg gcgcagctgt tcctggtggt gcagcatagt cgggacaacg aagcgttcag 12120
ggaggcgctg ctgaatatca ccgagcccga gggccgctgg ctcctggacc tggtgaacat 12180
tctgcagagc atcgtggtgc aggagcgcgg gctgccgctg tccgagaagc tggcggccat 12240
caacttctcg gtgctgagtt tgggcaagta ctacgctagg aagatctaca agaccccgta 12300
cgtgcccata gacaaggagg tgaagatcga cgggttttac atgcgcatga ccctgaaagt 12360
gctgaccctg agcgacgatc tgggggtgta ccgcaacgac aggatgcacc gtgcggtgag 12420
cgccagcagg cggcgcgagc tgagcgacca ggagctgatg catagtctgc agcgggccct 12480
gaccggggcc gggaccgagg gggagagcta ctttgacatg ggcgcggacc tgcactggca 12540
gcccagccgc cgggccttgg aggcggcggc aggaccctac gtagaagagg tggacgatga 12600
ggtggacgag gagggcgagt acctggaaga ctgatggcgc gaccgtattt ttgctagatg 12660
caacaacaac agccacctcc tgatcccgcg atgcgggcgg cgctgcagag ccagccgtcc 12720
ggcattaact cctcggacga ttggacccag gccatgcaac gcatcatggc gctgacgacc 12780
cgcaaccccg aagcctttag acagcagccc caggccaacc ggctctcggc catcctggag 12840
gccgtggtgc cctcgcgctc caaccccacg cacgagaagg tcctggccat cgtgaacgcg 12900
ctggtggaga acaaggccat ccgcggcgac gaggccggcc tggtgtacaa cgcgctgctg 12960
gagcgcgtgg cccgctacaa cagcaccaac gtgcagacca acctggaccg catggtgacc 13020
gacgtgcgcg aggccgtggc ccagcgcgag cggttccacc gcgagtccaa cctgggatcc 13080
atggtggcgc tgaacgcctt cctcagcacc cagcccgcca acgtgccccg gggccaggag 13140
gactacacca acttcatcag cgccctgcgc ctgatggtga ccgaggtgcc ccagagcgag 13200
gtgtaccagt ccgggccgga ctacttcttc cagaccagtc gccagggctt gcagaccgtg 13260
aacctgagcc aggctttcaa gaacttgcag ggcctgtggg gcgtgcaggc cccggtcggg 13320
gaccgcgcga cggtgtcgag cctgctgacg ccgaactcgc gcctgctgct gctgctggtg 13380
gcccccttca cggacagcgg cagcatcaac cgcaactcgt acctgggcta cctgattaac 13440
ctgtaccgcg aggccatcgg ccaggcgcac gtggacgagc agacctacca ggagatcacc 13500
cacgtgagcc gcgccctggg ccaggacgac ccgggcaacc tggaagccac cctgaacttt 13560
ttgctgacca accggtcgca gaagatcccg ccccagtacg cgctcagcac cgaggaggag 13620
cgcatcctgc gttacgtgca gcagagcgtg ggcctgttcc tgatgcagga gggggccacc 13680
cccagcgccg cgctcgacat gaccgcgcgc aacatggagc ccagcatgta cgccagcaac 13740
cgcccgttca tcaataaact gatggactac ttgcatcggg cggccgccat gaactctgac 13800
tatttcacca acgccatcct gaatccccac tggctcccgc cgccggggtt ctacacgggc 13860
gagtacgaca tgcccgaccc caatgacggg ttcctgtggg acgatgtgga cagcagcgtg 13920
ttctcccccc gaccgggtgc taacgagcgc cccttgtgga agaaggaagg cagcgaccga 13980
cgcccgtcct cggcgctgtc cggccgcgag ggtgctgccg cggcggtgcc cgaggccgcc 14040
agtcctttcc cgagcttgcc cttctcgctg aacagtatcc gcagcagcga gctgggcagg 14100
atcacgcgcc cgcgcttgct gggcgaagag gagtacttga atgactcgct gttgagaccc 14160
gagcgggaga agaacttccc caataacggg atagaaagcc tggtggacaa gatgagccgc 14220
tggaagacgt atgcgcagga gcacagggac gatccccggg cgtcgcaggg ggccacgagc 14280
cggggcagcg ccgcccgtaa acgccggtgg cacgacaggc agcggggaca gatgtgggac 14340
gatgaggact ccgccgacga cagcagcgtg ttggacttgg gtgggagtgg taacccgttc 14400
gctcacctgc gcccccgtat cgggcgcatg atgtaagaga aaccgaaaat aaatgatact 14460
caccaaggcc atggcgacca gcgtgcgttc gtttcttctc tgttgttgtt gtatctagta 14520
tgatgaggcg tgcgtacccg gagggtcctc ctccctcgta cgagagcgtg atgcagcagg 14580
cgatggcggc ggcggcgatg cagcccccgc tggaggctcc ttacgtgccc ccgcggtacc 14640
tggcgcctac ggaggggcgg aacagcattc gttactcgga gctggcaccc ttgtacgata 14700
ccacccggtt gtacctggtg gacaacaagt cggcggacat cgcctcgctg aactaccaga 14760
acgaccacag caacttcctg accaccgtgg tgcagaacaa tgacttcacc cccacggagg 14820
ccagcaccca gaccatcaac tttgacgagc gctcgcggtg gggcggccag ctgaaaacca 14880
tcatgcacac caacatgccc aacgtgaacg agttcatgta cagcaacaag ttcaaggcgc 14940
gggtgatggt ctcccgcaag acccccaatg gggtgacagt gacagaggat tatgatggta 15000
gtcaggatga gctgaagtat gaatgggtgg aatttgagct gcccgaaggc aacttctcgg 15060
tgaccatgac catcgacctg atgaacaacg ccatcatcga caattacttg gcggtggggc 15120
ggcagaacgg ggtgctggag agcgacatcg gcgtgaagtt cgacactagg aacttcaggc 15180
tgggctggga ccccgtgacc gagctggtca tgcccggggt gtacaccaac gaggctttcc 15240
atcccgatat tgtcttgctg cccggctgcg gggtggactt caccgagagc cgcctcagca 15300
acctgctggg cattcgcaag aggcagccct tccaggaagg cttccagatc atgtacgagg 15360
atctggaggg gggcaacatc cccgcgctcc tggatgtcga cgcctatgag aaaagcaagg 15420
aggatgcagc agctgaagca actgcagccg tagctaccgc ctctaccgag gtcaggggcg 15480
ataattttgc aagcgccgca gcagtggcag cggccgaggc ggctgaaacc gaaagtaaga 15540
tagtcattca gccggtggag aaggatagca agaacaggag ctacaacgta ctaccggaca 15600
agataaacac cgcctaccgc agctggtacc tagcctacaa ctatggcgac cccgagaagg 15660
gcgtgcgctc ctggacgctg ctcaccacct cggacgtcac ctgcggcgtg gagcaagtct 15720
actggtcgct gcccgacatg atgcaagacc cggtcacctt ccgctccacg cgtcaagtta 15780
gcaactaccc ggtggtgggc gccgagctcc tgcccgtcta ctccaagagc ttcttcaacg 15840
agcaggccgt ctactcgcag cagctgcgcg ccttcacctc gcttacgcac gtcttcaacc 15900
gcttccccga gaaccagatc ctcgtccgcc cgcccgcgcc caccattacc accgtcagtg 15960
aaaacgttcc tgctctcaca gatcacggga ccctgccgct gcgcagcagt atccggggag 16020
tccagcgcgt gaccgttact gacgccagac gccgcacctg cccctacgtc tacaaggccc 16080
tgggcatagt cgcgccgcgc gtcctctcga gccgcacctt ctaaatgtcc attctcatct 16140
cgcccagtaa taacaccggt tggggcctgc gcgcgcccag caagatgtac ggaggcgctc 16200
gccaacgctc cacgcaacac cccgtgcgcg tgcgcgggca cttccgcgct ccctggggcg 16260
ccctcaaggg ccgcgtgcgg tcgcgcacca ccgtcgacga cgtgatcgac caggtggtgg 16320
ccgacgcgcg caactacacc cccgccgccg cgcccgtctc caccgtggac gccgtcatcg 16380
acagcgtggt ggcggacgcg cgccggtacg cccgcgccaa gagccggcgg cggcgcatcg 16440
cccggcggca ccggagcacc cccgccatgc gcgcggcgcg agccttgctg cgcagggcca 16500
ggcgcacggg acgcagggcc atgctcaggg cggccagacg cgcggcttca ggcgccagcg 16560
ccggcaggac ccggagacgc gcggccacgg cggcggcagc ggccatcgcc agcatgtccc 16620
gcccgcggcg agggaacgtg tactgggtgc gcgacgccgc caccggtgtg cgcgtgcccg 16680
tgcgcacccg cccccctcgc acttgaagat gttcacttcg cgatgttgat gtgtcccagc 16740
ggcgaggagg atgtccaagc gcaaattcaa ggaagagatg ctccaggtca tcgcgcctga 16800
gatctacggc cctgcggtgg tgaaggagga aagaaagccc cgcaaaatca agcgggtcaa 16860
aaaggacaaa aaggaagaag aaagtgatgt ggacggattg gtggagtttg tgcgcgagtt 16920
cgccccccgg cggcgcgtgc agtggcgcgg gcggaaggtg caaccggtgc tgagacccgg 16980
caccaccgtg gtcttcacgc ccggcgagcg ctccggcacc gcttccaagc gctcctacga 17040
cgaggtgtac ggggatgatg atattctgga gcaggcggcc gagcgcctgg gcgagtttgc 17100
ttacggcaag cgcagccgtt ccgcaccgaa ggaagaggcg gtgtccatcc cgctggacca 17160
cggcaacccc acgccgagcc tcaagcccgt gaccttgcag caggtgctgc cgaccgcggc 17220
gccgcgccgg gggttcaagc gcgagggcga ggatctgtac cccaccatgc agctgatggt 17280
gcccaagcgc cagaagctgg aagacgtgct ggagaccatg aaggtggacc cggacgtgca 17340
gcccgaggtc aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt 17400
ggacatcaag attcccacgg agcccatgga aacgcagacc gagcccatga tcaagcccag 17460
caccagcacc atggaggtgc agacggatcc ctggatgcca tcggctccta gtcgaagacc 17520
ccggcgcaag tacggcgcgg ccagcctgct gatgcccaac tacgcgctgc atccttccat 17580
catccccacg ccgggctacc gcggcacgcg cttctaccgc ggtcatacca gcagccgccg 17640
ccgcaagacc accactcgcc gccgccgtcg ccgcaccgcc gctgcaacca cccctgccgc 17700
cctggtgcgg agagtgtacc gccgcggccg cgcacctctg accctgccgc gcgcgcgcta 17760
ccacccgagc atcgccattt aaactttcgc cagctttgca gatcaatggc cctcacatgc 17820
cgccttcgcg ttcccattac gggctaccga ggaagaaaac cgcgccgtag aaggctggcg 17880
gggaacggga tgcgtcgcca ccaccaccgg cggcggcgcg ccatcagcaa gcggttgggg 17940
ggaggcttcc tgcccgcgct gatccccatc atcgccgcgg cgatcggggc gatccccggc 18000
attgcttccg tggcggtgca ggcctctcag cgccactgag acacacttgg aaacatcttg 18060
taataaaccc atggactctg acgctcctgg tcctgtgatg tgttttcgta gacagatgga 18120
agacatcaat ttttcgtccc tggctccgcg acacggcacg cggccgttca tgggcacctg 18180
gagcgacatc ggcaccagcc aactgaacgg gggcgccttc aattggagca gtctctggag 18240
cgggcttaag aatttcgggt ccacgcttaa aacctatggc agcaaggcgt ggaacagcac 18300
cacagggcag gcgctgaggg ataagctgaa agagcagaac ttccagcaga aggtggtcga 18360
tgggctcgcc tcgggcatca acggggtggt ggacctggcc aaccaggccg tgcagcggca 18420
gatcaacagc cgcctggacc cggtgccgcc cgccggctcc gtggagatgc cgcaggtgga 18480
ggaggagctg cctcccctgg acaagcgggg cgagaagcga ccccgccccg atgcggagga 18540
gacgctgctg acgcacacgg acgagccgcc cccgtacgag gaggcggtga aactgggtct 18600
gcccaccacg cggcccatcg cgcccctggc caccggggtg ctgaaacccg aaaagcccgc 18660
gaccctggac ttgcctcctc cccagccttc ccgcccctct acagtggcta agcccctgcc 18720
gccggtggcc gtggcccgcg cgcgacccgg gggcaccgcc cgccctcatg cgaactggca 18780
gagcactctg aacagcatcg tgggtctggg agtgcagagt gtgaagcgcc gccgctgcta 18840
ttaaacctac cgtagcgctt aacttgcttg tctgtgtgtg tatgtattat gtcgccgccg 18900
ccgctgtcca ccagaaggag gagtgaagag gcgcgtcgcc gagttgcaag atggccaccc 18960
catcgatgct gccccagtgg gcgtacatgc acatcgccgg acaggacgct tcggagtacc 19020
tgagtccggg tctggtgcag tttgcccgcg ccacagacac ctacttcagt ctggggaaca 19080
agtttaggaa ccccacggtg gcgcccacgc acgatgtgac caccgaccgc agccagcggc 19140
tgacgctgcg cttcgtgccc gtggaccgcg aggacaacac ctactcgtac aaagtgcgct 19200
acacgctggc cgtgggcgac aaccgcgtgc tggacatggc cagcacctac tttgacatcc 19260
gcggcgtgct ggatcggggc cctagcttca aaccctactc cggcaccgcc tacaacagtc 19320
tggcccccaa gggagcaccc aacacttgtc agtggacata taaagccgat ggtgaaactg 19380
ccacagaaaa aacctataca tatggaaatg cacccgtgca gggcattaac atcacaaaag 19440
atggtattca acttggaact gacaccgatg atcagccaat ctacgcagat aaaacctatc 19500
agcctgaacc tcaagtgggt gatgctgaat ggcatgacat cactggtact gatgaaaagt 19560
atggaggcag agctcttaag cctgatacca aaatgaagcc ttgttatggt tcttttgcca 19620
agcctactaa taaagaagga ggtcaggcaa atgtgaaaac aggaacaggc actactaaag 19680
aatatgacat agacatggct ttctttgaca acagaagtgc ggctgctgct ggcctagctc 19740
cagaaattgt tttgtatact gaaaatgtgg atttggaaac tccagatacc catattgtat 19800
acaaagcagg cacagatgac agcagctctt ctattaattt gggtcagcaa gccatgccca 19860
acagacctaa ctacattggt ttcagagaca actttatcgg gctcatgtac tacaacagca 19920
ctggcaatat gggggtgctg gccggtcagg cttctcagct gaatgctgtg gttgacttgc 19980
aagacagaaa caccgagctg tcctaccagc tcttgcttga ctctctgggt gacagaaccc 20040
ggtatttcag tatgtggaat caggcggtgg acagctatga tcctgatgtg cgcattattg 20100
aaaatcatgg tgtggaggat gaacttccca actattgttt ccctctggat gctgttggca 20160
gaacagatac ttatcaggga attaaggcta atggaactga tcaaaccaca tggaccaaag 20220
atgacagtgt caatgatgct aatgagatag gcaagggtaa tccattcgcc atggaaatca 20280
acatccaagc caacctgtgg aggaacttcc tctacgccaa cgtggccctg tacctgcccg 20340
actcttacaa gtacacgccg gccaatgtta ccctgcccac caacaccaac acctacgatt 20400
acatgaacgg ccgggtggtg gcgccctcgc tggtggactc ctacatcaac atcggggcgc 20460
gctggtcgct ggatcccatg gacaacgtga accccttcaa ccaccaccgc aatgcggggc 20520
tgcgctaccg ctccatgctc ctgggcaacg ggcgctacgt gcccttccac atccaggtgc 20580
cccagaaatt tttcgccatc aagagcctcc tgctcctgcc cgggtcctac acctacgagt 20640
ggaacttccg caaggacgtc aacatgatcc tgcagagctc cctcggcaac gacctgcgca 20700
cggacggggc ctccatctcc ttcaccagca tcaacctcta cgccaccttc ttccccatgg 20760
cgcacaacac ggcctccacg ctcgaggcca tgctgcgcaa cgacaccaac gaccagtcct 20820
tcaacgacta cctctcggcg gccaacatgc tctaccccat cccggccaac gccaccaacg 20880
tgcccatctc catcccctcg cgcaactggg ccgccttccg cggctggtcc ttcacgcgtc 20940
tcaagaccaa ggagacgccc tcgctgggct ccgggttcga cccctacttc gtctactcgg 21000
gctccatccc ctacctcgac ggcaccttct acctcaacca caccttcaag aaggtctcca 21060
tcaccttcga ctcctccgtc agctggcccg gcaacgaccg gctcctgacg cccaacgagt 21120
tcgaaatcaa gcgcaccgtc gacggcgagg gctacaacgt ggcccagtgc aacatgacca 21180
aggactggtt cctggtccag atgctggccc actacaacat cggctaccag ggcttctacg 21240
tgcccgaggg ctacaaggac cgcatgtact ccttcttccg caacttccag cccatgagcc 21300
gccaggtggt ggacgaggtc aactacaagg actaccaggc cgtcaccctg gcctaccagc 21360
acaacaactc gggcttcgtc ggctacctcg cgcccaccat gcgccagggc cagccctacc 21420
ccgccaacta cccctacccg ctcatcggca agagcgccgt caccagcgtc acccagaaaa 21480
agttcctctg cgacagggtc atgtggcgca tccccttctc cagcaacttc atgtccatgg 21540
gcgcgctcac cgacctcggc cagaacatgc tctatgccaa ctccgcccac gcgctagaca 21600
tgaatttcga agtcgacccc atggatgagt ccacccttct ctatgttgtc ttcgaagtct 21660
tcgacgtcgt ccgagtgcac cagccccacc gcggcgtcat cgaggccgtc tacctgcgca 21720
cccccttctc ggccggtaac gccaccacct aagctcttgc ttcttgcaag ccatggccgc 21780
gggctccggc gagcaggagc tcagggccat catccgcgac ctgggctgcg ggccctactt 21840
cctgggcacc ttcgataagc gcttcccggg attcatggcc ccgcacaagc tggcctgcgc 21900
catcgtcaac acggccggcc gcgagaccgg gggcgagcac tggctggcct tcgcctggaa 21960
cccgcgctcg aacacctgct acctcttcga ccccttcggg ttctcggacg agcgcctcaa 22020
gcagatctac cagttcgagt acgagggcct gctgcgccgc agcgccctgg ccaccgagga 22080
ccgctgcgtc accctggaaa agtccaccca gaccgtgcag ggtccgcgct cggccgcctg 22140
cgggctcttc tgctgcatgt tcctgcacgc cttcgtgcac tggcccgacc gccccatgga 22200
caagaacccc accatgaact tgctgacggg ggtgcccaac ggcatgctcc agtcgcccca 22260
ggtggaaccc accctgcgcc gcaaccagga ggcgctctac cgcttcctca actcccactc 22320
cgcctacttt cgctcccacc gcgcgcgcat cgagaaggcc accgccttcg accgcatgaa 22380
tcaagacatg taaaccgtgt gtgtatgtta aatgtcttta ataaacagca ctttcatgtt 22440
acacatgcat ctgagatgat ttatttagaa atcgaaaggg ttctgccggg tctcggcatg 22500
gcccgcgggc agggacacgt tgcggaactg gtacttggcc agccacttga actcggggat 22560
cagcagtttg ggcagcgggg tgtcggggaa ggagtcggtc cacagcttcc gcgtcagttg 22620
cagggcgccc agcaggtcgg gcgcggagat cttgaaatcg cagttgggac ccgcgttctg 22680
cgcgcgggag ttgcggtaca cggggttgca gcactggaac accatcaggg ccgggtgctt 22740
cacgctcgcc agcaccgtcg cgtcggtgat gctctccacg tcgaggtcct cggcgttggc 22800
catcccgaag ggggtcatct tgcaggtctg ccttcccatg gtgggcacgc acccgggctt 22860
gtggttgcaa tcgcagtgca gggggatcag catcatctgg gcctggtcgg cgttcatccc 22920
cgggtacatg gccttcatga aagcctccaa ttgcctgaac gcctgctggg ccttggctcc 22980
ctcggtgaag aagaccccgc aggacttgct agagaactgg ttggtggcgc acccggcgtc 23040
gtgcacgcag cagcgcgcgt cgttgttggc cagctgcacc acgctgcgcc cccagcggtt 23100
ctgggtgatc ttggcccggt cggggttctc cttcagcgcg cgctgcccgt tctcgctcgc 23160
cacatccatc tcgatcatgt gctccttctg gatcatggtg gtcccgtgca ggcaccgcag 23220
cttgccctcg gcctcggtgc acccgtgcag ccacagcgcg cacccggtgc actcccagtt 23280
cttgtgggcg atctgggaat gcgcgtgcac gaagccctgc aggaagcggc ccatcatggt 23340
ggtcagggtc ttgttgctag tgaaggtcag cggaatgccg cggtgctcct cgttgatgta 23400
caggtggcag atgcggcggt acacctcgcc ctgctcgggc atcagctgga agttggcttt 23460
caggtcggtc tccacgcggt agcggtccat cagcatagtc atgatttcca tacccttctc 23520
ccaggccgag acgatgggca ggctcatagg gttcttcacc atcatcttag cgctagcagc 23580
cgcggccagg gggtcgctct cgtccagggt ctcaaagctc cgcttgccgt ccttctcggt 23640
gatccgcacc ggggggtagc tgaagcccac ggccgccagc tcctcctcgg cctgtctttc 23700
gtcctcgctg tcctggctga cgtcctgcag gaccacatgc ttggtcttgc ggggtttctt 23760
cttgggcggc agcggcggcg gagatgttgg agatggcgag ggggagcgcg agttctcgct 23820
caccactact atctcttcct cttcttggtc cgaggccacg cggcggtagg tatgtctctt 23880
cgggggcaga ggcggaggcg acgggctctc gccgccgcga cttggcggat ggctggcaga 23940
gccccttccg cgttcggggg tgcgctcccg gcggcgctct gactgacttc ctccgcggcc 24000
ggccattgtg ttctcctagg gaggaacaac aagcatggag actcagccat cgccaacctc 24060
gccatctgcc cccaccgccg acgagaagca gcagcagcag aatgaaagct taaccgcccc 24120
gccgcccagc cccgccacct ccgacgcggc cgtcccagac atgcaagaga tggaggaatc 24180
catcgagatt gacctgggct atgtgacgcc cgcggagcac gaggaggagc tggcagtgcg 24240
cttttcacaa gaagagatac accaagaaca gccagagcag gaagcagaga atgagcagag 24300
tcaggctggg ctcgagcatg acggcgacta cctccacctg agcggggggg aggacgcgct 24360
catcaagcat ctggcccggc aggccaccat cgtcaaggat gcgctgctcg accgcaccga 24420
ggtgcccctc agcgtggagg agctcagccg cgcctacgag ttgaacctct tctcgccgcg 24480
cgtgcccccc aagcgccagc ccaatggcac ctgcgagccc aacccgcgcc tcaacttcta 24540
cccggtcttc gcggtgcccg aggccctggc cacctaccac atctttttca agaaccaaaa 24600
gatccccgtc tcctgccgcg ccaaccgcac ccgcgccgac gcccttttca acctgggtcc 24660
cggcgcccgc ctacctgata tcgcctcctt ggaagaggtt cccaagatct tcgagggtct 24720
gggcagcgac gagactcggg ccgcgaacgc tctgcaagga gaaggaggag agcatgagca 24780
ccacagcgcc ctggtcgagt tggaaggcga caacgcgcgg ctggcggtgc tcaaacgcac 24840
ggtcgagctg acccatttcg cctacccggc tctgaacctg ccccccaaag tcatgagcgc 24900
ggtcatggac caggtgctca tcaagcgcgc gtcgcccatc tccgaggacg agggcatgca 24960
agactccgag gagggcaagc ccgtggtcag cgacgagcag ctggcccggt ggctgggtcc 25020
taatgctagt ccccagagtt tggaagagcg gcgcaaactc atgatggccg tggtcctggt 25080
gaccgtggag ctggagtgcc tgcgccgctt cttcgccgac gcggagaccc tgcgcaaggt 25140
cgaggagaac ctgcactacc tcttcaggca cgggttcgtg cgccaggcct gcaagatctc 25200
caacgtggag ctgaccaacc tggtctccta catgggcatc ttgcacgaga accgcctggg 25260
gcagaacgtg ctgcacacca ccctgcgcgg ggaggcccgg cgcgactaca tccgcgactg 25320
cgtctacctc tacctctgcc acacctggca gacgggcatg ggcgtgtggc agcagtgtct 25380
ggaggagcag aacctgaaag agctctgcaa gctcctgcag aagaacctca agggtctgtg 25440
gaccgggttc gacgagcgca ccaccgcctc ggacctggcc gacctcattt tccccgagcg 25500
cctcaggctg acgctgcgca acggcctgcc cgactttatg agccaaagca tgttgcaaaa 25560
ctttcgctct ttcatcctcg aacgctccgg aatcctgccc gccacctgct ccgcgctgcc 25620
ctcggacttc gtgccgctga ccttccgcga gtgccccccg ccgctgtgga gccactgcta 25680
cctgctgcgc ctggccaact acctggccta ccactcggac gtgatcgagg acgtcagcgg 25740
cgagggcctg ctcgagtgcc actgccgctg caacctctgc acgccgcacc gctccctggc 25800
ctgcaacccc cagctgctga gcgagaccca gatcatcggc accttcgagt tgcaagggcc 25860
cagcgaaggc gagggttcag ccgccaaggg gggtctgaaa ctcaccccgg ggctgtggac 25920
ctcggcctac ttgcgcaagt tcgtgcccga ggactaccat cccttcgaga tcaggttcta 25980
cgaggaccaa tcccatccgc ccaaggccga gctgtcggcc tgcgtcatca cccagggggc 26040
gatcctggcc caattgcaag ccatccagaa atcccgccaa gaattcttgc tgaaaaaggg 26100
ccgcggggtc tacctcgacc cccagaccgg tgaggagctc aaccccggct tcccccagga 26160
tgccccgagg aaacaagaag ctgaaagtgg agctgccgcc cgtggaggat ttggaggaag 26220
actgggagaa cagcagtcag gcagaggagg aggagatgga ggaagactgg gacagcactc 26280
aggcagagga ggacagcctg caagacagtc tggaggaaga cgaggaggag gcagaggagg 26340
aggtggaaga agcagccgcc gccagaccgt cgtcctcggc gggggagaaa gcaagcagca 26400
cggataccat ctccgctccg ggtcggggtc ccgctcgacc acacagtaga tgggacgaga 26460
ccggacgatt cccgaacccc accacccaga ccggtaagaa ggagcggcag ggatacaagt 26520
cctggcgggg gcacaaaaac gccatcgtct cctgcttgca ggcctgcggg ggcaacatct 26580
ccttcacccg gcgctacctg ctcttccacc gcggggtgaa ctttccccgc aacatcttgc 26640
attactaccg tcacctccac agcccctact acttccaaga agaggcagca gcagcagaaa 26700
aagaccagca gaaaaccagc agctagaaaa tccacagcgg cggcagcagg tggactgagg 26760
atcgcggcga acgagccggc gcaaacccgg gagctgagga accggatctt tcccaccctc 26820
tatgccatct tccagcagag tcgggggcag gagcaggaac tgaaagtcaa gaaccgttct 26880
ctgcgctcgc tcacccgcag ttgtctgtat cacaagagcg aagaccaact tcagcgcact 26940
ctcgaggacg ccgaggctct cttcaacaag tactgcgcgc tcactcttaa agagtagccc 27000
gcgcccgccc agtcgcagaa aaaggcggga attacgtcac ctgtgccctt cgccctagcc 27060
gcctccaccc atcatcatga gcaaagagat tcccacgcct tacatgtgga gctaccagcc 27120
ccagatgggc ctggccgccg gtgccgccca ggactactcc acccgcatga attggctcag 27180
cgccgggccc gcgatgatct cacgggtgaa tgacatccgc gcccaccgaa accagatact 27240
cctagaacag tcagcgctca ccgccacgcc ccgcaatcac ctcaatccgc gtaattggcc 27300
cgccgccctg gtgtaccagg aaattcccca gcccacgacc gtactacttc cgcgagacgc 27360
ccaggccgaa gtccagctga ctaactcagg tgtccagctg gcgggcggcg ccaccctgtg 27420
tcgtcaccgc cccgctcagg gtataaagcg gctggtgatc cggggcagag gcacacagct 27480
caacgacgag gtggtgagct cttcgctggg tctgcgacct gacggagtct tccaactcgc 27540
cggatcgggg agatcttcct tcacgcctcg tcaggccgtc ctgactttgg agagttcgtc 27600
ctcgcagccc cgctcgggtg gcatcggcac tctccagttc gtggaggagt tcactccctc 27660
ggtctacttc aaccccttct ccggctcccc cggccactac ccggacgagt tcatcccgaa 27720
cttcgacgcc atcagcgagt cggtggacgg ctacgattga atgtcccatg gtggcgcagc 27780
tgacctagct cggcttcgac acctggacca ctgccgccgc ttccgctgct tcgctcggga 27840
tctcgccgag tttgcctact ttgagctgcc cgaggagcac cctcagggcc cggcccacgg 27900
agtgcggatc gtcgtcgaag ggggcctcga ctcccacctg cttcggatct tcagccagcg 27960
tccgatcctg gtcgagcgcg agcaaggaca gacccttctg actctgtact gcatctgcaa 28020
ccaccccggc ctgcatgaaa gtctttgttg tctgctgtgt actgagtata ataaaagctg 28080
agatcagcga ctactccgga cttccgtgtg ttcctgaatc catcaaccag tctttgttct 28140
tcaccgggaa cgagaccgag ctccagctcc agtgtaagcc ccacaagaag tacctcacct 28200
ggctgttcca gggctccccg atcgccgttg tcaaccactg cgacaacgac ggagtcctgc 28260
tgagcggccc tgccaacctt actttttcca cccgcagaag caagctccag ctcttccaac 28320
ccttcctccc cgggacctat cagtgcgtct cgggaccctg ccatcacacc ttccacctga 28380
tcccgaatac cacagcgtcg ctccccgcta ctaacaacca aactaacctc caccaacgcc 28440
accgtcgcga cctttctgaa tctaatacta ccacccacac cggaggtgag ctccgaggtc 28500
aaccaacctc tgggatttac tacggcccct gggaggtggt tgggttaata gcgctaggcc 28560
tagttgcggg tgggcttttg gttctctgct acctatacct cccttgctgt tcgtacttag 28620
tggtgctgtg ttgctggttt aagaaatggg gaagatcacc ctagtgagct gcggtgcgct 28680
ggtggcggtg ttgctttcga ttgtgggact gggcggtgcg gctgtagtga aggagaaggc 28740
cgatccctgc ttgcatttca atcccaacaa atgccagctg agttttcagc ccgatggcaa 28800
tcggtgcgcg gtactgatca agtgcggatg ggaatgcgag aacgtgagaa tcgagtacaa 28860
taacaagact cggaacaata ctctcgcgtc cgtgtggcag cccggggacc ccgagtggta 28920
caccgtctct gtccccggtg ctgacggctc cccgcgcacc gtgaataata ctttcatttt 28980
tgcgcacatg tgcgacacgg tcatgtggat gagcaagcag tacgatatgt ggccccccac 29040
gaaggagaac atcgtggtct tctccatcgc ttacagcctg tgcacggcgc taatcaccgc 29100
tatcgtgtgc ctgagcattc acatgctcat cgctattcgc cccagaaata atgccgaaaa 29160
agaaaaacag ccataacgtt ttttttcaca cctttttcag accatggcct ctgttaaatt 29220
tttgctttta tttgccagtc tcattgccgt cattcatgga atgagtaatg agaaaattac 29280
tatttacact ggcactaatc acacattgaa aggtccagaa aaagccacag aagtttcatg 29340
gtattgttat tttaatgaat cagatgtatc tactgaactc tgtggaaaca ataacaaaaa 29400
aaatgagagc attactctca tcaagtttca atgtggatct gacttaaccc taattaacat 29460
cactagagac tatgtaggta tgtattatgg aactacagca ggcatttcgg acatggaatt 29520
ttatcaagtt tctgtgtctg aacccaccac gcctagaatg accacaacca caaaaactac 29580
acctgttacc actatgcagc tcactaccaa taacattttt gccatgcgtc aaatggtcaa 29640
caatagcact caacccaccc cacccagtga ggaaattccc aaatccatga ttggcattat 29700
tgttgctgta gtggtgtgca tgttgatcat cgccttgtgc atggtgtact atgccttctg 29760
ctacagaaag cacagactga acgacaagct ggaacactta ctaagtgttg aattttaatt 29820
ttttagaacc atgaagatcc taggcctttt aattttttct atcattacct ctgctctatg 29880
caattctgac aatgaggacg ttactgtcgt tgtcggatca aattatacac tgaaaggtcc 29940
agcgaagggt atgctttcgt ggtattgcta ttttggatct gacactacag aaactgaatt 30000
atgcaatctt aagaatggca aaattcaaaa ttctaaaatt aacaattata tatgcaatgg 30060
tactgatctg atactcctca atatcacgaa atcatatgct ggcagttaca cctgccctgg 30120
agatgatgct gacagtatga ttttttacaa agtaactgtt gttgatccca ctactccacc 30180
tccacccacc acaactactc acaccacaca cacagatcaa accgcagcag aggaggcagc 30240
aaagttagcc ttgcaggtcc aagacagttc atttgttggc attaccccta cacctgatca 30300
gcggtgtccg gggctgctag tcagcggcat tgtcggtgtg ctttcgggat tagcagtcat 30360
aatcatctgc atgttcattt ttgcttgctg ctatagaagg ctttaccgac aaaaatcaga 30420
cccactgctg aacctctatg tttaattttt tccagagtca tgaaggcagt tagcgctcta 30480
gttttttgtt ctttgattgg cattgttttt tgcaatccta ttcctaaagt tagctttatt 30540
aaagatgtga atgttactga ggggggcaat gtgacactgg taggtgtaga gggtgctgaa 30600
aacaccacct ggacaaaata ccacctcaat gggtggaaag atatttgcaa ttggagtgta 30660
ttagtttata catgtgaggg agttaatctt accattgtca atgccacctc agctcaaaat 30720
ggtagaattc aaggacaaag tgtcagtgta tctaatgggt attttaccca acatactttt 30780
atctatgacg ttaaagtcat accactgcct acgcctagcc cacctagcac taccacacag 30840
acaacccaca ctacacagac aaccacatac agtacattaa atcagcctac caccactaca 30900
gcagcagagg ttgccagctc gtctggggtc cgagtggcat ttttgatgtg ggccccatct 30960
agcagtccca ctgctagtac caatgagcag actactgaat ttttgtccac tgtcgagagc 31020
cacaccacag ctacctccag tgccttctct agcaccgcca atctctcctc gctttcctct 31080
acaccaatca gtcccgctac tactcctagc cccgctcctc ttcccactcc cctgaagcaa 31140
acagacggcg gcatgcaatg gcagatcacc ctgctcattg tgatcgggtt ggtcatcctg 31200
gccgtgttgc tctactacat cttctgccgc cgcattccca acgcgcaccg caagccggtc 31260
tacaagccca tcattgtcgg gcagccggag ccgcttcagg tggaaggggg tctaaggaat 31320
cttctcttct cttttacagt atggtgattg aactatgatt cctagacaat tcttgatcac 31380
tattcttatc tgcctcctcc aagtctgtgc caccctcgct ctggtggcca acgccagtcc 31440
agactgtatt gggcccttcg cctcctacgt gctctttgcc ttcaccacct gcatctgctg 31500
ctgtagcata gtctgcctgc ttatcacctt cttccagttc attgactgga tctttgtgcg 31560
catcgcctac ctgcgccacc acccccagta ccgcgaccag cgagtggcgc ggctgctcag 31620
gctcctctga taagcatgcg ggctctgcta cttctcgcgc ttctgctgtt agtgctcccc 31680
cgtcccgtcg acccccggtc ccccacccag tcccccgagg aggtccgcaa atgcaaattc 31740
caagaaccct ggaaattcct caaatgctac cgccaaaaat cagacatgca tcccagctgg 31800
atcatgatca ttgggatcgt gaacattctg gcctgcaccc tcatctcctt tgtgatttac 31860
ccctgctttg actttggttg gaactcgcca gaggcgctct atctcccgcc tgaacctgac 31920
acaccaccac agcaacctca ggcacacgca ctaccaccac tacagcctag gccacaatac 31980
atgcccatat tagactatga ggccgagcca cagcgaccca tgctccccgc tattagttac 32040
ttcaatctaa ccggcggaga tgactgaccc actggccaac aacaacgtca acgaccttct 32100
cctggacatg gacggccgcg cctcggagca gcgactcgcc caacttcgca ttcgccagca 32160
gcaggagaga gccgtcaagg agctgcagga tgcggtggcc atccaccagt gcaagagagg 32220
catcttctgc ctggtgaaac aggccaagat ctcctacgag gtcactccaa acgaccatcg 32280
cctctcctac gagctcctgc agcagcgcca gaagttcacc tgcctggtcg gagtcaaccc 32340
catcgtcatc acccagcagt ctggcgatac caaggggtgc atccactgct cctgcgactc 32400
ccccgactgc gtccacactc tgatcaagac cctctgcggc ctccgcgacc tcctccccat 32460
gaactaatca cccccttatc cagtgaaata aagatcatat tgatgatgat tttacagaaa 32520
taaaaaataa tcatttgatt tgaaataaag atacaatcat attgatgatt tgagtttaac 32580
aaaaaaataa agaatcactt acttgaaatc tgataccagg tctctgtcca tgttttctgc 32640
caacaccact tcactcccct cttcccagct ctggtactgc aggccccggc gggctgcaaa 32700
cttcctccac acgctgaagg ggatgtcaaa ttcctcctgt ccctcaatct tcattttatc 32760
ttctatcaga tgtccaaaaa gcgcgtccgg gtggatgatg acttcgaccc cgtctacccc 32820
tacgatgcag acaacgcacc gaccgtgccc ttcatcaacc cccccttcgt ctcttcagat 32880
ggattccaag agaagcccct gggggtgttg tccctgcgac tggccgaccc cgtcaccacc 32940
aagaacgggg aaatcaccct caagctggga gagggggtgg acctcgattc ctcgggaaaa 33000
ctcatctcca acacggccac caaggccgcc gcccctctca gtttttccaa caacaccatt 33060
tcccttaaca tggatcaccc cttttacact aaagatggaa aattatcctt acaagtttct 33120
ccaccattaa atatactgag aacaagcatt ctaaacacac tagctttagg ttttggatca 33180
ggtttaggac tccgtggctc tgccttggca gtacagttag tctctccact tacatttgat 33240
actgatggaa acataaagct taccttagac agaggtttgc atgttacaac aggagatgca 33300
attgaaagca acataagctg ggctaaaggt ttaaaatttg aagatggagc catagcaacc 33360
aacattggaa atgggttaga gtttggaagc agtagtacag aaacaggtgt tgatgatgct 33420
tacccaatcc aagttaaact tggatctggc cttagctttg acagtacagg agccataatg 33480
gctggtaaca aagaagacga taaactcact ttgtggacaa cacctgatcc atcaccaaac 33540
tgtcaaatac tcgcagaaaa tgatgcaaaa ctaacacttt gcttgactaa atgtggtagt 33600
caaatactgg ccactgtgtc agtcttagtt gtaggaagtg gaaacctaaa ccccattact 33660
ggcaccgtaa gcagtgctca ggtgtttcta cgttttgatg caaacggtgt tcttttaaca 33720
gaacattcta cactaaaaaa atactggggg tataggcagg gagatagcat agatggcact 33780
ccatatacca atgctgtagg attcatgccc aatttaaaag cttatccaaa gtcacaaagt 33840
tctactacta aaaataatat agtagggcaa gtatacatga atggagatgt ttcaaaacct 33900
atgcttctca ctataaccct caatggtact gatgacagca acagtacata ttcaatgtca 33960
ttttcataca cctggactaa tggaagctat gttggagcaa catttggggc taactcttat 34020
accttctcat acatcgccca agaatgaaca ctgtatccca ccctgcatgc caacccttcc 34080
caccccactc tgtggaacaa actctgaaac acaaaataaa ataaagttca agtgttttat 34140
tgattcaaca gttttacagg attcgagcag ttatttttcc tccaccctcc caggacatgg 34200
aatacaccac cctctccccc cgcacagcct tgaacatctg aatgccattg gtgatggaca 34260
tgcttttggt ctccacgttc cacacagttt cagagcgagc cagtctcggg tcggtcaggg 34320
agatgaaacc ctccgggcac tcccgcatct gcacctcaca gctcaacagc tgaggattgt 34380
cctcggtggt cgggatcacg gttatctgga agaagcagaa gagcggcggt gggaatcata 34440
gtccgcgaac gggatcggcc ggtggtgtcg catcaggccc cgcagcagtc gctgccgccg 34500
ccgctccgtc aagctgctgc tcagggggtc cgggtccagg gactccctca gcatgatgcc 34560
cacggccctc agcatcagtc gtctggtgcg gcgggcgcag cagcgcatgc ggatctcgct 34620
caggtcgctg cagtacgtgc aacacagaac caccaggttg ttcaacagtc catagttcaa 34680
cacgctccag ccgaaactca tcgcgggaag gatgctaccc acgtggccgt cgtaccagat 34740
cctcaggtaa atcaagtggt gccccctcca gaacacgctg cccacgtaca tgatctcctt 34800
gggcatgtgg cggttcacca cctcccggta ccacatcacc ctctggttga acatgcagcc 34860
ccggatgatc ctgcggaacc acagggccag caccgccccg cccgccatgc agcgaagaga 34920
ccccgggtcc cggcaatggc aatggaggac ccaccgctcg tacccgtgga tcatctggga 34980
gctgaacaag tctatgttgg cacagcacag gcatatgctc atgcatctct tcagcactct 35040
caactcctcg ggggtcaaaa ccatatccca gggcacgggg aactcttgca ggacagcgaa 35100
ccccgcagaa cagggcaatc ctcgcacaga acttacattg tgcatggaca gggtatcgca 35160
atcaggcagc accgggtgat cctccaccag agaagcgcgg gtctcggtct cctcacagcg 35220
tggtaagggg gccggccgat acgggtgatg gcgggacgcg gctgatcgtg ttcgcgaccg 35280
tgtcatgatg cagttgcttt cggacatttt cgtacttgct gtagcagaac ctggtccggg 35340
cgctgcacac cgatcgccgg cggcggtctc ggcgcttgga acgctcggtg ttgaaattgt 35400
aaaacagcca ctctctcaga ccgtgcagca gatctagggc ctcaggagtg atgaagatcc 35460
catcatgcct gatggctctg atcacatcga ccaccgtgga atgggccaga cccagccaga 35520
tgatgcaatt ttgttgggtt tcggtgacgg cgggggaggg aagaacagga agaaccatga 35580
ttaactttta atccaaacgg tctcggagta cttcaaaatg aagatcgcgg agatggcacc 35640
tctcgccccc gctgtgttgg tggaaaataa cagccaggtc aaaggtgata cggttctcga 35700
gatgttccac ggtggcttcc agcaaagcct ccacgcgcac atccagaaac aagacaatag 35760
cgaaagcggg agggttctct aattcctcaa tcatcatgtt acactcctgc accatcccca 35820
gataattttc atttttccag ccttgaatga ttcgaactag ttcgtgaggt aaatccaagc 35880
cagccatgat aaagagctcg cgcagagcgc cctccaccgg cattcttaag cacaccctca 35940
taattccaag atattctgct cctggttcac ctgcagcaga ttgacaagcg gaatatcaaa 36000
atctctgccg cgatccctga gctcctccct cagcaataac tgtaagtact ctttcatatc 36060
ctctccgaaa tttttagcca taggaccacc aggaataaga ttagggcaag ccacagtaca 36120
gataaaccga agtcctcccc agtgagcatt gccaaatgca agactgctat aagcatgctg 36180
gctagacccg gtgatatctt ccagataact ggacagaaaa tcgcccaggc aatttttaag 36240
aaaatcaaca aaagaaaaat cctccaggtg gacgtttaga gcctcgggaa caacgatgaa 36300
gtaaatgcaa gcggtgcgtt ccagcatggt tagttagctg atctgtagaa aaaacaaaaa 36360
tgaacattaa accatgctag cctggcgaac aggtgggtaa atcgttctct ccagcaccag 36420
gcaggccacg gggtctccgg cgcgaccctc gtaaaaattg tcgctatgat tgaaaaccat 36480
cacagagaga cgttcccggt ggccggcgtg aatgattcga caagatgaat acacccccgg 36540
aacattggcg tccgcgagtg aaaaaaagcg cccgaggaag caataaggca ctacaatgct 36600
cagtctcaag tccagcaaag cgatgccatg cggatgaagc acaaaattct caggtgcgta 36660
caaaatgtaa ttactcccct cctgcacagg cagcaaagcc cccgatccct ccaggtacac 36720
atacaaagcc tcagcgtcca tagcttaccg agcagcagca cacaacaggc gcaagagtca 36780
gagaaaggct gagctctaac ctgtccaccc gctctctgct caatatatag cccagatcta 36840
cactgacgta aaggccaaag tctaaaaata cccgccaaat aatcacacac gcccagcaca 36900
cgcccagaaa ccggtgacac actcaaaaaa atacgcgcac ttcctcaaac gcccaaaact 36960
gccgtcattt ccgggttccc acgctacgtc atcaaaacac gactttcaaa ttccgtcgac 37020
cgttaaaaac gtcacccgcc ccgcccctaa cggtcgcccg tctctcagcc aatcagcgcc 37080
ccgcatcccc aaattcaaac acctcatttg catattaacg cgcacaaaaa gtttgaggta 37140
tattattgat gatggcctcc ggggtccact gcaattactt ctcgaccaat tctcatgttt 37200
gacagcttat catcgaattt ctgccattca tccgcttatt atcacttatt caggcgtagc 37260
aaccaggcgt ttaagggcac caataactgc cttaaaaaaa ttacgccccg ccctgccact 37320
catcgcagta ctgttgtaat tcattaagca ttctgccgac atggaagcca tcacagacgg 37380
catgatgaac ctgaatcgcc agcggcatca gcaccttgtc gccttgcgta taatatttgc 37440
ccatggtgaa aacgggggcg aagaagttgt ccatattggc cacgtttaaa tcaaaactgg 37500
tgaaactcac ccagggattg gctgagacga aaaacatatt ctcaataaac cctttaggga 37560
aataggccag gttttcaccg taacacgcca catcttgcga atatatgtgt agaaactgcc 37620
ggaaatcgtc gtggtattca ctccagagcg atgaaaacgt ttcagtttgc tcatggaaaa 37680
cggtgtaaca agggtgaaca ctatcccata tcaccagctc accgtctttc attgccatac 37740
ggaattccgg atgagcattc atcaggcggg caagaatgtg aataaaggcc ggataaaact 37800
tgtgcttatt tttctttacg gtctttaaaa aggccgtaat atccagctga acggtctggt 37860
tataggtaca ttgagcaact gactgaaatg cctcaaaatg ttctttacga tgccattggg 37920
atatatcaac ggtggtatat ccagtgattt ttttctccat tttagcttcc ttagctcctg 37980
aaaatctcga taactcaaaa aatacgcccg gtagtgatct tatttcatta tggtgaaagt 38040
tggaacctct tacgtgccga tcaacgtctc attttcgcca aaagttggcc cagggcttcc 38100
cggtatcaac agggacacca ggatttattt attctgcgaa gtgatcttcc gtcacaggta 38160
tttattcgcg ataagctcat ggagcggcgt aaccgtcgca caggaaggac agagaaagcg 38220
cggatctggg aagtgacgga cagaacggtc aggacctgga ttggggaggc ggttgccgcc 38280
gctgctgctg acggtgtgac gttctctgtt ccggtcacac cacatacgtt ccgccattcc 38340
tatgcgatgc acatgctgta tgccggtata ccgctgaaag ttctgcaaag cctgatggga 38400
cataagtcca tcagttcaac ggaagtctac acgaaggttt ttgcgctgga tgtggctgcc 38460
cggcaccggg tgcagtttgc gatgccggag tctgatgcgg ttgcgatgct gaaacaatta 38520
tcctgagaat aaatgccttg gcctttatat ggaaatgtgg aactgagtgg atatgctgtt 38580
tttgtctgtt aaacagagaa gctggctgtt atccactgag aagcgaacga aacagtcggg 38640
aaaatctccc attatcgtag agatccgcat tattaatctc aggagcctgt gtagcgttta 38700
taggaagtag tgttctgtca tgatgcctgc aagcggtaac gaaaacgatt tgaatatgcc 38760
ttcaggaaca atagaaatct tcgtgcggtg ttacgttgaa gtggagcgga ttatgtcagc 38820
aatggacaga acaacctaat gaacacagaa ccatgatgtg gtctgtcctt ttacagccag 38880
taggctcgcc gcagtcgagc gacggcgaag ccctcgagtg agcgaggaag caccagggaa 38940
cagcacttat atattctgct tacacacgat gcctgaaaaa acttcccttg gggttatcca 39000
cttatccacg gggatatttt tataattatt ttttttatag tttttagatc ttctttttta 39060
gagcgccttg taggccttta tccatgctgg ttctagagaa ggtgttgtga caaattgccc 39120
tttcagtgtg acaaatcacc ctcaaatgac agtcctgtct gtgacaaatt gcccttaacc 39180
ctgtgacaaa ttgccctcag aagaagctgt tttttcacaa agttatccct gcttattgac 39240
tcttttttat ttagtgtgac aatctaaaaa cttgtcacac ttcacatgga tctgtcatgg 39300
cggaaacagc ggttatcaat cacaagaaac gtaaaaatag cccgcgaatc gtccagtcaa 39360
acgacctcac tgaggcggca tatagtctct cccgggatca aaaacgtatg ctgtatctgt 39420
tcgttgacca gatcagaaaa tctgatggca ccctacagga acatgacggt atctgcgaga 39480
tccatgttgc taaatatgct gaaatattcg gattgacctc tgcggaagcc agtaaggata 39540
tacggcaggc attgaagagt ttcgcgggga aggaagtggt tttttatcgc cctgaagagg 39600
atgccggcga tgaaaaaggc tatgaatctt ttccttggtt tatcaaacgt gcgcacagtc 39660
catccagagg gctttacagt gtacatatca acccatatct cattcccttc tttatcgggt 39720
tacagaaccg gtttacgcag tttcggctta gtgaaacaaa agaaatcacc aatccgtatg 39780
ccatgcgttt atacgaatcc ctgtgtcagt atcgtaagcc ggatggctca ggcatcgtct 39840
ctctgaaaat cgactggatc atagagcgtt accagctgcc tcaaagttac cagcgtatgc 39900
ctgacttccg ccgccgcttc ctgcaggtct gtgttaatga gatcaacagc agaactccaa 39960
tgcgcctctc atacattgag aaaaagaaag gccgccagac gactcatatc gtattttcct 40020
tccgcgatat cacttccatg acgacaggat agtctgaggg ttatctgtca cagatttgag 40080
ggtggttcgt cacatttgtt ctgacctact gagggtaatt tgtcacagtt ttgctgtttc 40140
cttcagcctg catggatttt ctcatacttt ttgaactgta atttttaagg aagccaaatt 40200
tgagggcagt ttgtcacagt tgatttcctt ctctttccct tcgtcatgtg acctgatatc 40260
gggggttagt tcgtcatcat tgatgagggt tgattatcac agtttattac tctgaattgg 40320
ctatccgcgt gtgtacctct acctggagtt tttcccacgg tggatatttc ttcttgcgct 40380
gagcgtaaga gctatctgac agaacagttc ttctttgctt cctcgccagt tcgctcgcta 40440
tgctcggtta cacggctgcg gcgagcgcta gtgataataa gtgactgagg tatgtgctct 40500
tcttatctcc ttttgtagtg ttgctcttat tttaaacaac tttgcggttt tttgatgact 40560
ttgcgatttt gttgttgctt tgcagtaaat tgcaagattt aataaaaaaa cgcaaagcaa 40620
tgattaaagg atgttcagaa tgaaactcat ggaaacactt aaccagtgca taaacgctgg 40680
tcatgaaatg acgaaggcta tcgccattgc acagtttaat gatgacagcc cggaagcgag 40740
gaaaataacc cggcgctgga gaataggtga agcagcggat ttagttgggg tttcttctca 40800
ggctatcaga gatgccgaga aagcagggcg actaccgcac ccggatatgg aaattcgagg 40860
acgggttgag caacgtgttg gttatacaat tgaacaaatt aatcatatgc gtgatgtgtt 40920
tggtacgcga ttgcgacgtg ctgaagacgt atttccaccg gtgatcgggg ttgctgccca 40980
taaaggtggc gtttacaaaa cctcagtttc tgttcatctt gctcaggatc tggctctgaa 41040
ggggctacgt gttttgctcg tggaaggtaa cgacccccag ggaacagcct caatgtatca 41100
cggatgggta ccagatcttc atattcatgc agaagacact ctcctgcctt tctatcttgg 41160
ggaaaaggac gatgtcactt atgcaataaa gcccacttgc tggccggggc ttgacattat 41220
tccttcctgt ctggctctgc accgtattga aactgagtta atgggcaaat ttgatgaagg 41280
taaactgccc accgatccac acctgatgct ccgactggcc attgaaactg ttgctcatga 41340
ctatgatgtc atagttattg acagcgcgcc taacctgggt atcggcacga ttaatgtcgt 41400
atgtgctgct gatgtgctga ttgttcccac gcctgctgag ttgtttgact acacctccgc 41460
actgcagttt ttcgatatgc ttcgtgatct gctcaagaac gttgatctta aagggttcga 41520
gcctgatgta cgtattttgc ttaccaaata cagcaatagt aatggctctc agtccccgtg 41580
gatggaggag caaattcggg atgcctgggg aagcatggtt ctaaaaaatg ttgtacgtga 41640
aacggatgaa gttggtaaag gtcagatccg gatgagaact gtttttgaac aggccattga 41700
tcaacgctct tcaactggtg cctggagaaa tgctctttct atttgggaac ctgtctgcaa 41760
tgaaattttc gatcgtctga ttaaaccacg ctgggagatt agataatgaa gcgtgcgcct 41820
gttattccaa aacatacgct caatactcaa ccggttgaag atacttcgtt atcgacacca 41880
gctgccccga tggtggattc gttaattgcg cgcgtaggag taatggctcg cggtaatgcc 41940
attactttgc ctgtatgtgg tcgggatgtg aagtttactc ttgaagtgct ccggggtgat 42000
agtgttgaga agacctctcg ggtatggtca ggtaatgaac gtgaccagga gctgcttact 42060
gaggacgcac tggatgatct catcccttct tttctactga ctggtcaaca gacaccggcg 42120
ttcggtcgaa gagtatctgg tgtcatagaa attgccgatg ggagtcgccg tcgtaaagct 42180
gctgcactta ccgaaagtga ttatcgtgtt ctggttggcg agctggatga tgagcagatg 42240
gctgcattat ccagattggg taacgattat cgcccaacaa gtgcttatga acgtggtcag 42300
cgttatgcaa gccgattgca gaatgaattt gctggaaata tttctgcgct ggctgatgcg 42360
gaaaatattt cacgtaagat tattacccgc tgtatcaaca ccgccaaatt gcctaaatca 42420
gttgttgctc ttttttctca ccccggtgaa ctatctgccc ggtcaggtga tgcacttcaa 42480
aaagccttta cagataaaga ggaattactt aagcagcagg catctaacct tcatgagcag 42540
aaaaaagctg gggtgatatt tgaagctgaa gaagttatca ctcttttaac ttctgtgctt 42600
aaaacgtcat ctgcatcaag aactagttta agctcacgac atcagtttgc tcctggagcg 42660
acagtattgt ataagggcga taaaatggtg cttaacctgg acaggtctcg tgttccaact 42720
gagtgtatag agaaaattga ggccattctt aaggaacttg aaaagccagc accctgatgc 42780
gaccacgttt tagtctacgt ttatctgtct ttacttaatg tcctttgtta caggccagaa 42840
agcataactg gcctgaatat tctctctggg cccactgttc cacttgtatc gtcggtctga 42900
taatcagact gggaccacgg tcccactcgt atcgtcggtc tgattattag tctggga 42957
<210> 44
<211> 38123
<212> DNA
<213> 人工序列
<220>
<223> pLWH-B03
<400> 44
ctatctatat aatatacctt atagatggaa tggtgccaac atgtaaatga ggtaatttaa 60
aaaagtgcgc gctgtgtggt gattggctgc ggggttaacg gctaaaaggg gcggcgcgac 120
cgtgggaaaa tgacgtgact tatgtgggag gagttatgtt gcaagttatt acggtaaatg 180
tgacgtaaaa cgaggtgtgg tttgaacacg gaagtagaca gttttcccac gcttactgac 240
aggatatgag gtagttttgg gcggatgcaa gtgaaaattc tccattttcg cgcgaaaact 300
aaatgaggaa gtgaatttct gagtcatttc gcggttatgc cagggtggag tatttgccga 360
gggccgagta gactttgacc gtttacgtgg aggtttcgat taccgtgttt ttcacctaaa 420
tttccgcgta cggtgtcaaa gttctgtgtt tttacgtagg tgtcagctga tcgctagggt 480
atttaaacct gacgagttcc gtcaagaggc cactcttgag tgccagcgag aagagttttc 540
tcctccgcgc cgcaagtcag ttctgcgctt tgaaaatgag acacctgcgc ttcctgccac 600
aggaggttat ctccagtgag accgggatcg aaatactgga gtttgtggta aataccctaa 660
tgggagacga cccggaaccg ccagtgcagc ctttcgatcc acctacgctg cacgatctgt 720
atgatttaga gatagacggg ccggaggatc ccaatgagga agctgtgaat gggtttttta 780
ctgattctat gctgctagct gctgatgaag gattggacat aaaccctcct cctgagacac 840
ttgttacccc aggggtggtt gtggaaagcg gcataggtgg gaaaaaattg cctgatctgg 900
gagcagctga aatggacttg cgttgttatg aagagggttt tcctcccagt gatgatgaag 960
atggggaaac tgagcagtcc atccataccg cagtaaatga gggagtaaaa gctgccagcg 1020
atgtttttaa gttggactgt ccggagctgc ctggacatgg ctgtaagtct tgtgaatttc 1080
acaggaataa cactggaatg aaagaactat tgtgctcgct ttgctatatg agaatgcact 1140
gccactttat ttacagtaag tgtatttaag tgaaatttaa aggaatagtg tagctattta 1200
ataactgttg aatggtagat ttatgttttt ttcttgcgat tttttgtagg tcctgtgtct 1260
gatgatgagt caccttctcc tgattcaact acctcacctc ctgaaattca ggcgcccgca 1320
cctgcaaacg tatgcaagcc cattcctgtg aagcctaagc ctgggaaacg ccctgctgtg 1380
gataagcttg aggacttgtt ggagggtggg gatggacctt tggaccttag tacccggaaa 1440
ctgccaaggc aatgagtgcc ctgcagctgt gtttatttaa tgtgacgtca tgtaataaaa 1500
ttatgtcagc tgctgagtgt tttattactt cttgggtggg gacttggata tataagtagg 1560
agcagatctg tgtggttagc tcacagcaac ctgctgccat ccatggaggt ttgggctatc 1620
ttggaagacc tcagacagac taagctactg ctagaaaacg cctcggacgg agtctctggc 1680
ctttggagat tctggttcgg tggtgatcta gctaggctag tgtttaggat aaaacaggac 1740
tacagggaag aatttgaaaa gttattggac gatagtccgg gactttttga agctcttaac 1800
ttgggtcatc aggctcattt taaggagaag gttttatcag ttttagattt ttctactcct 1860
ggtagaactg ctgctgctgt agcttttctt acttttatat tggataaatg gatccgccaa 1920
actcacttca gcaagggata cgttttggat ttcatagcag cagctttgtg gagaacatgg 1980
aaggctcgca ggatgaggac aatcttagat tactggccag tgcagcctct gggagtagca 2040
gggatactga gacacccacc gaccatgcca gcggttctgc aggaggagca gcaggaggac 2100
aatccgagag ccggcctgga ccctccggtg gaggagtagc tgacctgttt cctgaactgc 2160
gacgggtgct tactaggtct acgaccagtg gacagaacag gggaattaag agggagagga 2220
atcctagtgg gaataattca agaaccgagt tggctttaag tttaatgagc cgcaggcgtc 2280
ctgaaactgt ttggtggcat gaggttcaga gcgaaggcag ggatgaagtt tcaatattgc 2340
aggagaaata ttcactagaa caacttaaga cctgttggtt ggaacctgag gatgattggg 2400
aggtggccat taggaattat gctaagatat ctctgaggcc tgataaacaa tatagaatta 2460
ctaagaagat taatattaga aatgcatgct acatatcagg gaatggggca gaggttataa 2520
tagatacaca agataaagca gtttttagat gttgtatgat gggtatgtgg ccaggggttg 2580
tcggcatgga agcagtaaca cttatgaata ttaggtttaa aggggatggg tataatggca 2640
ttgtatttat ggctaacact aagctgattc tacatggttg tagctttttt gggtttaata 2700
atacgtgtgt agaagcttgg gggcaagtta gtgtgagggg ttgtagtttt tatgcatgct 2760
ggattgcaac atcaggtagg gtcaagagtc agttgtctgt gaagaaatgc atgtttgaga 2820
gatgtaatct tggcatactg aatgaaggtg aagcaagggt ccgccactgc gcagctacag 2880
aaactggctg cttcattcta ataaagggaa atgccagtgt gaagcataat atgatctgtg 2940
gacattcgga tgagaggcct tatcagatgc tgacctgcgc tggtggacat tgcaatattc 3000
ttgctaccgt gcatatcgtt tcacatgcac gcaaaaaatg gcctgtattt gaacataatg 3060
tgattaccaa gtgcaccatg cacataggtg gtcgcagggg aatgtttatg ccttaccagt 3120
gtaacatgaa tcatgtgaag gtaatgttgg aaccagatgc cttttccaga gtgagcttaa 3180
caggaatctt tgatatgaat attcaactat ggaagatcct gagatatgat gacactaaac 3240
caagggtgcg cgcatgcgaa tgcggaggca agcatgctag attccagccg gtgtgcgtgg 3300
atgtgactga agacttgaga cccgatcatt tggtgcttgc ctgcactgga gcggagttcg 3360
gttctagtgg tgaagaaact gactaaagtg agtagtgggg caagatgtgg atggggactt 3420
tcaggttggt aaggtgggca gattgggtaa attttgttaa tttctgtctt gcagctgcca 3480
tgagtggaag cgcttctttt gaggggggag tatttagccc ttatctgacg ggcaggctcc 3540
caccatgggc aggagttcgt cagaatgtca tgggatccac tgtggatggg agacccgtcc 3600
agcccgccaa ttcctcaacg ctgacctatg ccactttgag ttcgtcacca ttggatgcag 3660
ctgcagccgc cgccgctact gctgccgcca acaccatcct tggaatgggc tattatggaa 3720
gcatcgttgc caattccagt tcctctaata acccttcaac cctggctgag gacaagctac 3780
ttgttctctt ggcgcagctc gaggccttaa cccaacgctt aggcgaactg tctaagcagg 3840
tggcccagtt gcgtgagcaa actgagtctg ctgttgccac agcaaagtct aaataaagat 3900
ctcaaatcaa taaataaaga aatacttgat ataaaacaaa tgaatgttta tttgattttt 3960
cgcgcgcggt atgccctgga ccatcggtct cgatcattga gaacgcggtg gatcttttcc 4020
agtaccctgt aaaggtggga ttgaatgttt agatacatgg gcattagtcc gtctcggggg 4080
tggagatagc tccattgaag agcctcttgc tccggggtag tgttataaat cacccagtca 4140
tagcaaggtc ggagtgcatg gtgttgcaca atatctttta ggagcagact aattgcaacg 4200
gggaggccct tagtgtaggt gtttacaaat ctgttgagct gggacgggtg catccggggt 4260
gaaattatat gcattttgga ctggatcttg aggttggcaa tgttgccgcc tagatcccgt 4320
ctcgggttca tattgtgcag gaccaccaag acagtgtatc cggtgcactt gggaaattta 4380
tcatgcagct tagagggaaa agcatgaaaa aatttggaga cgcctttgtg accccccaga 4440
ttctccatgc actcatccat aatgatagcg atggggccgt gggcagcggc acgggcgaac 4500
acgttccggg ggtctgaaac atcatagtta tgctcctgag tcaggtcatc ataagccatt 4560
ttaataaact ttgggcggag ggtgccagat tgggggatga aagttccctc tggcccggga 4620
gcatagtttc cctcacatat ttgcatttcc caggctttca gttcagaggg ggggatcatg 4680
tccacctgcg gggctataaa aaataccgtt tctggagccg gggtgattaa ctgggacgag 4740
agcaaattcc taagcagctg agacttgccg cacccagtgg gaccgtaaat gaccccaatt 4800
acgggttgca gatggtagtt tagggaacga cagctgccgt cctcccggag caggggggcc 4860
acttcgttca tcatttccct tacatggata ttttcccgca ccaagtccgt taggaggcgc 4920
tctcccccaa gggatagaag ctcctggagc gaggagaagt ttttcagcgg cttcagcccg 4980
tcagccatgg gcattttgga aagagtctgt tgcaagagct cgagccggtc ccagagctcg 5040
gtgatgtgct ctatggcatc tcgatccagc agacctcctc gtttcgcggg ttgggacggc 5100
tcctggagta gggaatcaga cgatgggcgt ccagcgctgc cagggtccga tccttccatg 5160
gtcgcagcgt ccgagtcagg gttgtttccg tcacggtgaa ggggtgcgcg cctggttggg 5220
cgcttgcgag ggtgcgcttc agactcatcc tgctggtcga gaaccgctgc cgattggcgc 5280
cctgcatgtc ggccaggtag cagtttacca tgagttcgta gttgagcgcc tcggccgcgt 5340
ggcctttggc acggagctta cctttggaag ttttatggca ggcggggcag tagatacatt 5400
tgagggcata caacttgggc gcgaggaaaa tggattcggg ggagtatgca tccgcaccgc 5460
aggaggcgca gacggtttcg cactccacga gccaggtcag atccggctca tcggggtcaa 5520
aaacaagttt tccgccatgt tttttgatgc gtttcttacc tttggtttcc atgagttcgt 5580
gtccccgctg ggtgacaaag aggctgtccg tgtccccgta gaccgacttt atgggcctgt 5640
cctcgagcgg agtgcctcgg tcctcttcgt agaggaaccc agcccactct gatacaaaag 5700
cgcgtgtcca ggccagcaca aaggaggcca cgtgggaggg gtagcggtcg ttgtcaacca 5760
gggggtccac cttctctacg gtatgtaaac acatgtcccc ctcctccaca tccaagaatg 5820
tgattggctt gtaagtgtag gccacgtgac caggggtccc cgccgggggg gtataaaagg 5880
gggcgggcct ctgttcgtcc tcactgtctt ccggatcgct gtccaggagc gccagctgtt 5940
ggggtaggta ttccctctcg aaggcgggca tgacctctgc actcaggttg tcagtttcta 6000
ggaacgagga ggatttgata ttgacagtac cagcagagat gcctttcata agactctcgt 6060
ccatctggtc agaaaacaca atcttcttgt tgtccagctt ggtggcaaat gatccataga 6120
gggcattgga tagaagcttg gcgatggagc gcatggtttg gttcttttcc ttgtccgcgc 6180
gctccttggc ggtgatgtta agctggacgt actcgcgcgc cacacatttc cattcaggaa 6240
agatggttgt cagttcatcc ggaactattc tgattcgcca tcccctattg tgcagggtta 6300
tcagatccac actggtggcc acctcgcctc ggaggggctc attggtccag cagagtcgac 6360
ctccttttct tgaacagaaa ggggggaggg ggtctagcat gaactcatca ggggggtccg 6420
catctatggt aaatattccc ggtagcaaat ctttgtcaaa atagctgatg gtggcgggat 6480
catccaaggt catctgccat tctcgaactg ccagcgcgcg ctcatagggg ttaagagggg 6540
tgccccaggg catggggtgg gtgagcgcgg aggcatacat gccacagata tcgtagacat 6600
agaggggctc ttcgaggatg ccgatgtaag tgggataaca tcgcccccct ctgatgcttg 6660
ctcgcacata gtcatagagt tcatgtgagg gggcaagaag acccgggccc agattggtgc 6720
ggttgggttt ttccgccctg taaacgatct ggcgaaagat ggcatgggaa ttggaagaga 6780
tagtaggtct ctggaatatg ttaaaatggg catgaggtaa gcctacagag tcccttatga 6840
agtgggcata tgactcttgc agcttggcta ccagctcggc ggtgatgagt acatccaggg 6900
cacagtagtc gagagtttcc tggatgatgt cataacgcgg ttggcttttc ttttcccaca 6960
gctcgcggtt gagaaggtat tcttcgtgat ccttccagta ctcttcgagg ggaaacccgt 7020
ctttttctgc acggtaagag cccaacatgt agaactgatt gactgccttg tagggacagc 7080
atcccttctc cactgggaga gagtatgctt gggctgcatt gcgcagcgag gtatgagtga 7140
gggcaaaagt gtccctgacc atgactttga ggaattgata cttgaagtcg atgtcatcac 7200
aggccccctg ttcccagagt tggaagtcca cccgcttctt gtaggcgggg ttgggcaaag 7260
cgaaagtaac atcattgaag aggatcttgc cggccctggg catgaaattt cgggtgattt 7320
tgaaaggctg aggaacctct gctcggttat tgataacctg agcggccaag acgatctcat 7380
caaagccatt gatgttgtgc cccactatgt acagttctaa gaatcgaggg gtgcccctga 7440
catgaggcag cttcttgagt tcttcaaaag tgagatctgt agggtcagtg agagcatagt 7500
gttcgagggc ccattcgtgc acgtgagggt tcgctttaag gaaggaggac cagaggtcca 7560
ctgccagtgc tgtttgtaac tggtcccggt actgacgaaa atgctgtccg actgccatct 7620
tttctggggt gacgcaatag aaggtttggg ggtcctgccg ccagcgatcc cacttgagtt 7680
ttatggcgag gtcataggcg atgttgacga gccgctggtc tccagagagt ttcatgacca 7740
gcatgaaggg gattagctgc ttgccaaagg accccatcca ggtgtaggtt tccacatcgt 7800
aggtgagaaa gagcctttct gtgcgaggat gagagccaat cgggaagaac tggatctcct 7860
gccaccagtt ggaggaatgg ctgttgatgt gatggaagta gaactccctg cgacgcgccg 7920
agcattcatg cttgtgcttg tacagacggc cgcagtactc gcagcgattc acgggatgca 7980
ccttatgaat gagttgtacc tgacttcctt tgacgagaaa tttcagtgga aaattgaggc 8040
ctggcgcttg tacctcgcgc tttactatgt tgtctgcatc ggcatgacca tcttctgtct 8100
cgatggtggt catgctgacg agccctcgcg ggaggcaagt ccagacctcg gcgcggcagg 8160
ggcggagctc gaggacgaga gcgcgcaggc cggagctgtc cagggtcctg agacgctgcg 8220
gagtcaggtt agtaggcagt gtcaggagat taacttgcat gatcttttgg agggcgtgag 8280
ggaggttcag atagtacttg atctcaacgg gtccgttggt ggagatgtcg atggcttgca 8340
gggttccgtg tcccttgggc gctaccaccg tgcccttgtt tttcattttg gacggcggtg 8400
gctctgttgc ttcttgcatg tttagaagcg gtgtcgaggg cgcgcaccgg gcggcagggg 8460
cggctcggga cccggcggca tggctggcag tggtacgtcg gcgccgcgcg cgggtaggtt 8520
ctggtactgc gccctgagaa gactcgcatg cgcgacgacg cggcggttga catcctggat 8580
ctgacgcctc tgggtgaaag ctaccggccc cgtgagcttg aacctgaaag agagttcaac 8640
agaatcaatc tcggtatcgt tgacggcggc ttgcctaagg atttcttgca cgtcgccaga 8700
gttgtcctgg taggcgatct cggccatgaa ctgctcgatc tcttcctctt gaagatctcc 8760
gcggcccgct ctctcgacgg tggccgcgag gtcgttggag atgcgcccaa tgagttgaga 8820
gaatgcattc atgcccgcct cgttccagac gcggctgtag accacagccc ccacgggatc 8880
tctcgcgcgc atgaccacct gggcgaggtt gagctccacg tggcgggtga agaccgcata 8940
gttgcatagg cgctggaaaa ggtagttgag tgtggtggcg atgtgctcgg tgacgaagaa 9000
atacatgatc catcgtctca gcggcatctc gctgacatcg cccagcgctt ccaagcgctc 9060
catggcctcg tagaagtcca cggcaaagtt aaaaaactgg gagttacgcg cggacacggt 9120
caactcctct tccagaagac ggataagttc ggcgatggtg gtgcgcacct cgcgctcgaa 9180
agcccctggg atttcttcct caatctcttc ttcttccact aacatctctt cctcttcagg 9240
tggggctgca ggaggagggg gaacgcggcg acgccggcgg cgcacgggca gacggtcgat 9300
gaatctttca atgacctctc cgcggcggcg gcgcatggtc tcggtgacgg cacgaccgtt 9360
ctccctgggt ctcagagtga agacgcctcc gcgcatctcc ctgaagtggt gactgggagg 9420
ctctccgttg ggcagggaca ccgcgctgat tatgcatttt atcaattgcc ccgtaggtac 9480
tccgcgcaag gacctgatcg tctcaagatc cacgggatct gaaaaccttt cgacgaaagc 9540
gtctaaccag tcgcaatcgc aaggtaggct gagcactgtt tcttgcgggc gggggcggct 9600
agacgctcgg tcggggttct ctctttcttc tccttcctcc tcttgggagg gtgagacgat 9660
gctgctggtg atgaaattaa aataggcagt tttgagacgg cggatggtgg cgaggagcac 9720
caggtctttg ggtccggctt gttggatacg caggcgatga gccattcccc aagcattatc 9780
ctgacatctg gccagatctt tatagtagtc ttgcatgagt cgttccacgg gcacttcttc 9840
ttcgcccgct ctgccatgca tgcgagtgat cccgaacccg cgcatgggct ggacaagtgc 9900
caggtccgct acaacccttt cggcgaggat ggcttgctgc acctgggtga gggtggcttg 9960
gaagtcgtca aagtccacga agcggtggta ggccccggtg ttgattgtgt aggagcagtt 10020
ggccatgact gaccagttga ctgtctggtg cccagggcgc acgagctcgg tgtacttgag 10080
gcgcgagtat gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca ggtactggta 10140
gccaatgaga aagtgtggcg gtggctggcg gtacaggggc catcgctctg tagccggggc 10200
tccgggggcg aggtcttcca gcatgaggcg gtggtagccg tagatgtacc tggacatcca 10260
ggtgataccg gaggcggtgg tggatgcacg tgggaactcg cgcacgcggt tccagatgtt 10320
gcgcagcggc atgaagtagt tcatggtagg cacggtctgg ccagtgaggc gcgcgcagtc 10380
attgacgctc tgtagacacg gagaaaacga aagcgatgag cggctcgact ccgtggtctg 10440
ggggaacgtg aacgggttgg gtcgcggtgt accccggttc gagtccaaag ctaagcgatc 10500
acgctcggat cggccggagc cgcggctaac gtggtattgg ctatcccgtc tcgacccagc 10560
cgacgaatat ccagggtacg gagtagagtc gtttttgctg ctttttcctg gacgtgtgcc 10620
attgccacgt caagctttag aacgctcagt tctcgggccg tgagtggctc gcgcccgtag 10680
tctggagaat cagtcgccag ggttgcgttg cggtatgccc cggttggagc ctaagcgcgg 10740
ctcgtatcgg ccggtttccg cgacaagcga gggtttggca gccccgttat ttccaagacc 10800
ccgccagccg acttctccag tttacgggag cgagcccttt tttttttttt tttgtttttg 10860
tcgcccagat gcatccagtg ctgcgacaga tgcgccccca gcaacaggcc ccttctcagc 10920
aacagccaca aaaggctctt cttgctcctg caactactgc agctgcagcc gtgagcggcg 10980
cgggacagcc cgcctatgat ctggacttgg aagagggcga gggattggcg cgcctggggg 11040
ctccatcgcc cgagcggcac ccgcgggtgc aactaaaaaa ggactctcgc gaggcgtacg 11100
tgccccagca gaacctgttc agggacagga gcggcgagga gccagaggag atgcgagcat 11160
ctcgatttaa cgcgggtcgc gagctgcgcc acggtctgga tcgaagacgg gtgctgcaag 11220
acgaggattt tgaggtcgat gaagtcacag ggatcagccc agctagggca catgtggccg 11280
cggccaacct agtctcggcc tacgagcaga ccgtgaagga ggagcgcaac ttccaaaaat 11340
cttttaacaa ccatgtgcgc accctgatcg cccgcgagga agtgaccctg ggtctgatgc 11400
atctgtggga cctgatggag gctatcgccc aaaaccccac tagcaaacca ctgacagctc 11460
agctgtttct ggtggttcaa catagcaggg acaacgaggc attcagggag gcgttgttga 11520
acatcaccga gcctgatggg agatggctgt atgatctgat caacatcctg caaagtatta 11580
tagtgcagga acgtagcctg ggtttggctg agaaagtggc agctatcaac tactcggtct 11640
tgagcctggg caaatactac gctcgcaaga tctacaagac cccctacgta cccatagaca 11700
aggaggtgaa gatagatggg ttttacatgc gcatgactct gaaggtgctg actctgagcg 11760
acgatctggg ggtgtatcgc aatgacagga tgcaccgcgc ggtgagcgcc agcaggaggc 11820
gcgagctgag cgacagagaa cttatgcaca gcttgcaaag agctctaacg ggggccggga 11880
ctgatgggga gaactacttt gacatgggag cggatttgca atggcaaccc agtcgcaggg 11940
ccatggaggc tgcagggtgt gagcttcctt acatagaaga ggtggatgaa gtcgaggacg 12000
aggagggcga gtacttggaa gactgatggc gcgacccgta tttttgctag atggaacagc 12060
agcaggcacc ggaccccgca atgcgggcgg cgctgcagag ccagccgtcc ggcattaact 12120
cctcggacga ttggacccag gccatgcaac gcataatggc gctgacgacc cgcaaccccg 12180
aagcctttag acagcaaccc caggccaacc gcctttctgc catactggag gccgtagtgc 12240
cctcccgctc caaccccacc cacgagaagg tcctggctat cgtgaacgcg ctggtggaga 12300
acaaggccat ccgtcccgat gaggccgggc tggtatacaa tgctctcttg gagcgcgtgg 12360
cccgttacaa cagcagcaac gtgcaaacca acctggaccg gatggtgacc gatgtgcgcg 12420
aggccgtgtc tcagcgcgag cgattccagc gcgacgccaa cttggggtcg ttggtagcgc 12480
taaacgcttt cctcagcacc cagcccgcca acgtgccccg tggtcagcaa gactatacaa 12540
actttttgag tgcattgaga ctcatggtag ctgaggtgcc ccagagcgag gtgtaccagt 12600
ccgggccaga ttacttcttc cagaccagca gacagggctt gcagacagtg aacctgactc 12660
aggctttcaa gaacctgaag ggtctgtggg gagtgcacgc cccagtaggg gatcgcgcga 12720
ccgtgtctag cttgctgact cccaactccc gcctgctgct gctgctggta tcccccttta 12780
ctgacagcgg tagcattgac cgcaactcgt acttgggcta cctgcttaac ctgtatcgcg 12840
aggccatagg acagagccag gtggacgagc agacctatca agaaatcacc caagtgagcc 12900
gcgccctggg tcaggaagac acgggcagtt tggaagccac cctgaacttc ttgctaacca 12960
accggtcaca gaagatccct cctcagtatg cgcttaccgc tgaggaggag cggatcctca 13020
gatacgtgca acagagcgtt ggactgttcc tgatgcagga gggggcgaca cctaccgccg 13080
cgctggacat gacagctcga aacatggagc ccagcatgta tgctagtaac aggcctttca 13140
ttaacaaact gctggactac ctgcacaggg cggccgccat gaactctgat tatttcacca 13200
atgctatcct gaacccacac tggctgcccc cacctggttt ctacactggc gagtacgaca 13260
tgcccgaccc caatgacggg ttcctgtggg acgatgtgga cagcagcata ttttccccgc 13320
ctcccggtta tacagtttgg aagaaggaag ggggcgatag aagacactct tccgtgtcgc 13380
tatccggaac ggctggtgct gccgcgaccg tgcccgaagc tgcaagtcct ttccctagct 13440
tgcccttttc actaaacagc gttcgcagca gtgaactggg gagaataacc cgcccgcgct 13500
tgatgggcga ggatgagtac ttgaatgact ctttgctgag gccagagagg gaaaagaact 13560
tccccaacaa tggaatagag agtctggtgg ataagatgag tagatggaag acctatgcgc 13620
aggatcacag agacgagccc aggatcttgg gggctacaag cagaccgatc cgtagacgcc 13680
agcgccacga caggcagatg ggtcttgtgt gggacgatga ggactctgcc gatgatagca 13740
gcgtgttgga cttgggtgga agaggagggg gcaacccgtt cgctcatctg cgtcccagat 13800
tcgggcgcat gttgtaaaag tgaaagtaaa ataaaaaggc aactcaccaa ggccatggcg 13860
accgagcgtg cgttcgttct tttttgttat ctgtgtctag tacgatgagg agacgagccg 13920
tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcttacgag agcgtgatgc 13980
agcaacaggc ggcgatgata cagcccccac tggaggctcc cttcgtaccc ccacggtacc 14040
tggcgcctac ggaagggaga aacagcattc gttactcgga gctgtcgccc ctgtacgata 14100
ccaccaagtt gtatctggtg gacaacaagt cggcggacat cgcctccctg aactatcaga 14160
acgaccacag caacttcctg accacggtgg tgcagaacaa tgactttacc cccacggagg 14220
ctagcaccca gaccatcaac tttgacgagc ggtcgcgatg gggcggtcag ctgaagacca 14280
tcatgcacac caacatgccc aacgtgaacg agtacatgtt cagcaacaag ttcaaggcga 14340
gggtgatggt gtccagaaaa gctcctgaag gtgttacagt aaatgacacc tatgatcata 14400
aagaggatat cttgaagtat gagtggtttg agttcatttt accagaaggc aacttttcag 14460
ccaccatgac gatcgacctg atgaacaatg ccatcattga caactacctg gaaattggca 14520
gacagaatgg agtgctggaa agtgacattg gtgttaagtt tgacactaga aatttcaggc 14580
tcgggtggga ccccgaaact aagttgatta tgccaggtgt ctacacttat gaggcattcc 14640
atcctgacat tgtattgctg cctggttgcg gggtagactt tactgaaagc cgacttagca 14700
acttgcttgg catcaggaag agacatccat tccaggaggg tttcaaaatc atgtatgaag 14760
atcttgaagg gggtaatatt cctgcccttt tggatgtcac tgcctatgag gaaagcaaaa 14820
aggataccac tactgaaaca accacactgg ctgttgcaga ggaaactagt gaagatgatg 14880
atataactag aggagatacc tatataactg aaaaacaaaa acgtgaagct gcagctgctg 14940
aagttaaaaa agagttaaag atccaacctc tagaaaaaga cagcaagagt agaagctaca 15000
atgtcttgga agacaaaatc aacacagcct accgcagttg gtacctgtcc tacaattacg 15060
gtaaccctga gaaaggaata aggtcttgga cactgctcac cacttcagat gtcacctgtg 15120
gggcagagca ggtctactgg tcgctccctg acatgatgca agacccagtc accttccgct 15180
ccacaagaca agtcaacaac tacccagtgg tgggtgcaga gcttatgccc gtcttctcaa 15240
agagtttcta caatgagcaa gccgtgtact ctcagcagct ccgacaggcc acttcgctca 15300
cgcacgtctt caaccgcttc cctgagaacc agatcctcat ccgcccgccg gcgcccacaa 15360
ttaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggaccctg ccgttacgca 15420
gcagtatccg gggagtccag cgcgtgaccg ttactgacgc cagacgccgc acctgtccct 15480
acgtttacaa ggccctgggc atagtcgcgc cgcgcgttct ttcaagccgc actttctaaa 15540
aaaaaaaaaa atgtccattc tcatctcgcc cagtaataat accggttggg gactgtatgc 15600
gcccaccaag atgtatggag gcgcccgcaa gcgctctacc cagcatcctg tgcgcgttcg 15660
cggtcatttc cgcgctccct ggggcgcact caagggtcgt acccgcactc ggaccacggt 15720
cgatgatgtg atcgaccagg tggtcgccga tgctcgtaat tatactccta ctgcgcctac 15780
atctactgtg gatgcagtta ttgacagtgt ggtggcagac gcccgcgcct atgctcgccg 15840
gaagagccga aggaggcgca tcgccaggcg ccacagggct actcccgcca tgcgagccgc 15900
aaaagctatt ctgcggaggg ccaaacgtgt ggggcgaaga gccatgctta gagcggccag 15960
acgcgcggct tcaggtgcca gcagcggcag gtcccgcagg cgcgcggcca cggcggcagc 16020
agcggccatt gccaacatgg cccaaccgcg aagaggcaat gtgtactggg tgcgtgatgc 16080
cactaccggc cagcgcgtgc ccgtgcgcac ccgcccccct cgcacttaga agatactgag 16140
cagtctccga tgttgtgtcc cagcggcaag tatgtccaag cgcaaataca aggaagagat 16200
gctccaggtc atcgcgcctg aaatctacgg tccgccggtg aaggatgaaa aaaagccccg 16260
caaaatcaag cgggtcaaaa ataacaaaaa ggaagaagat gacgatgatg ggctggtgga 16320
gtttgtgcgc gagttcgccc caagacggcg cgtgcagtgg cgcgggcgca aagtgcgtca 16380
agtgctcaga cccgggacca ctgtggtttt tacacctggc gagcgttcca gcactacttt 16440
taaacggtcc tatgatgagg tgtacgggga tgacgatatt cttgagcagg cggcagaccg 16500
ccttgacgag tttgcttatg gcaagcgcac tagatccagt cccaaagagg aggctgtgtc 16560
cattcctttg gatcatggaa atcccacccc cagcctcaaa ccagtcaccc tgcagcaagt 16620
gctgcccgtg cctgcgcgga gaggcgtaaa gcgcgagggt gaggacctat atcccaccat 16680
gcagctaatg gtgcccaagc gccagaggct agaagacgta ctggagaaaa tgaaagtgga 16740
tgccgatatc cagcctgagg tcaaagtaag acctatcaag gaagtggcgc caggtttggg 16800
agtacaaacc ttcgacatca agattcccac cgagtccatg gaagtgcaga ccgaacctgc 16860
aaaacccacc acctcaattg aggtgcaaac ggaaccctgg atgcccgcgc ccgttgccgc 16920
ccccagcacc actcgaagat cacgacgaaa gtacggccca gcaagtctgc taatgcccaa 16980
ctatgctctg cacccatcca tcattcccac tccgggttac agaggcactc gctactatcg 17040
aaaccggagc aacacctctc gccgccgcaa accacctgca agtcgcactc gccgtcgccg 17100
ccgccgcaac actgccagca aattgactcc cgccgccctg gtgcggagag tgtaccgcga 17160
tggtcgcgct gaacctctga cgctgccgcg cgcgcgctac catccaagca tcaccactta 17220
atgactgttg acgctgcctc cttgcagata tggccctcac ttgccgcctt cgcgtcccca 17280
ttactggcta ccgaggaaga aactcgcgcc gtagaaggat gttggggcga gggatgcgcc 17340
gccacagacg aaggcgcgct atcagcagac gattaggggg tggctttttg ccagctctta 17400
tacccatcat cgccgcagcg atcggggcga taccaggcat agcttcagtg gcggttcagg 17460
cctcgcagcg ccactaacat tggaaaaaac ttataaataa aaaatagaat ggactctgac 17520
gctcctggtc ctgtgactat gtttttgtag agatggaaga catcaatttt tcatccctgg 17580
ctccgcgaca cggcacgagg ccgtacatgg gcacctggag cgacatcggc acgagccaac 17640
tgaacggggg cgccttcaat tggagcagta tctggagcgg gcttaaaaat tttggctcga 17700
ccgtaaaaac ctatgggaac aaagcttgga acagcagcac agggcaggct ctgagaaata 17760
agcttaagga acaaaacttc caacagaagg tggtcgatgg gatcgcctct ggtattaacg 17820
gcgtagtgga tctggccaac caggctgtac aaaaacagat aaacagccgc ctggacccgc 17880
cgcccgcaac ccctggtgaa atggaagtgg aggaagaact tcctccgctg gaaaagcggg 17940
gcgacaagcg tccgcgaccc gagctagagc agacgctggt gacgcgcgca gacgagcccc 18000
cttcatatga ggaggcagta aagctcggaa tgcccactac caggcctgta gctcacatgg 18060
ctaccggggt gatgaaacct tctcagtcac atcgacccgc caccttggac ttgcctcctc 18120
cccctgcttc tgcggcgcct gttcccaaac ctgtcgctac cagaaagccc accgccgtac 18180
agcccgtcgc cgtagccaga ccgcgtcctg ggggcacacc gcgcccgaaa gcaaactggc 18240
aaagtactct gaacagcatc gtgggtctgg gcgtgcagag tgtaaagcgc cgtcgctgct 18300
attaattaaa tatggagtag cgcttaactt gcttgtctgt gtgtatgtat catcaccacg 18360
ccgccgcagc agaggagaaa ggaagaggtc gcgcgccgag gctgagttgc tttcaagatg 18420
gccaccccat cgatgatgcc ccaatgggca tacatgcaca tcgccggaca ggatgcttcg 18480
gagtacctca gtccgggtct ggtgcagttc gcccgtgcaa cagacaccta cttcagtatg 18540
gggaacaaat ttagaaaccc cacagtggcg cccacccacg atgtgaccac cgaccgtagc 18600
cagcgcctga tgctgcgctt cgtgcccgtt gaccgggaag acaataccta ctcttacaaa 18660
gttcgctaca cgctggctgt aggcgacaac agagtgcttg acatggccag cacattcttt 18720
gacattcggg gggtgcttga tagaggtcct agcttcaagc catattccgg cacagcttac 18780
aattcactcg ctcctaaggg cgcgcccaat acatctcagt ggatagttac aacaaatggg 18840
gacaatgcag taactaccac cacaaacaca tttggcattg cttccatgaa gggagacaat 18900
attactaaag aaggtttgca aattgggaaa gacattacca ctactgaagg agaagaaaag 18960
cccatttatg ccgataaaac atatcagcca gagcctcaag ttggagaaga atcatggact 19020
gatactgatg gaacaaatga aaagtttggt ggaagagccc ttaaaccagc taccaacatg 19080
aagccatgct acgggtcttt tgcaagacct acaaacataa aagggggcca agctaaaaac 19140
agaaaagtaa aaccaacaac cgaaggaggg gttgaaactg aggaaccaga tattgatatg 19200
gaatttttcg atggtagaga tgctgttgca ggagctttag cgcctgaaat tgtgctttat 19260
acggaaaatg taaatttgga aactccagac agtcatgtgg tatataaacc agaaacgtct 19320
aataactctc atgcaaattt gggtcaacaa gccatgccta acagacccaa ttacattggc 19380
ttcagggata acttcgtagg cctaatgtac tacaacagta ctggaaatat gggagttttg 19440
gctggccaag catcacaact gaatgcagtg gttgacttgc aggacagaaa tactgaactg 19500
tcatatcagc ttttgcttga ttctctggga gacagaacca gatacttcag catgtggaat 19560
caggctgtgg acagttacga tcccgatgtt cgcattattg aaaatcatgg catcgaggat 19620
gaactgccta attactgttt tcctctgaat ggcataggac cagggcacac atatcaaggc 19680
attaaagtta aaaccgatga cactaatgga tgggaaaaag atgctaatgt tgctccagct 19740
aatgaaataa ccataggcaa caacctggct atggaaatta atatccaagc taacctttgg 19800
agaagttttc tgtactctaa tgtggctttg taccttccag atgtttacaa gtacacgcca 19860
cctaacatta ctttgcccac taacaccaac acctatgagt acatgaacgg gcgagtggta 19920
tccccatccc tggttgattc atacatcaac attggcgcca ggtggtctct tgacccaatg 19980
gacaatgtga atccattcaa ccaccaccgc aatgctggtc tgcgctacag gtccatgctt 20040
ctgggaaatg gtcgttatgt gcctttccac atacaagtgc ctcagaaatt ctttgctgtc 20100
aagaacctac ttcttctacc tggctcctac acctacgagt ggaacttccg aaaggatgtg 20160
aacatggtcc tgcaaagttc ccttggaaat gacctcagaa cggatggtgc taccataagt 20220
ttcaccagca tcaatctcta tgccaccttc ttccccatgg ctcacaacac agcttccacc 20280
cttgaagcca tgctgcgcaa cgataccaat gatcagtcat ttaacgacta cctctctgca 20340
gctaacatgc tttaccccat tcctgccaat gcaaccaaca ttccaatttc catcccatct 20400
cgcaactggg cagccttcag gggctggtcc ttcaccagac tcaaaaccaa ggagactcca 20460
tctcttggat cagggttcga tccctacttc gtatattctg gatctattcc ctacctggat 20520
ggcacctttt accttaacca cactttcaag aaggtctcca tcatgtttga ctcctcagtc 20580
agctggcctg gcaatgacag gctgttgagt ccaaatgagt ttgaaatcaa gcgcactgtg 20640
gacggggaag gatacaacgt ggcacaatgc aacatgacca aagactggtt cctggttcag 20700
atgcttgcca attacaacat tggctaccag ggcttttaca tccctgaggg atacaaggat 20760
cgcatgtact cctttttcag aaacttccag cctatgagca ggcaggtggt tgatgaggtt 20820
aattacactg actacaaagc cgtcacctta ccataccaac acaacaactc tggctttgta 20880
gggtaccttg cacctactat gagacaaggg gaaccttacc cagccaatta tccatacccg 20940
ctcatcggaa ctactgccgt taagagtgtc acccagaaaa agttcctgtg cgacaggacc 21000
atgtggcgca ttcccttctc cagcaacttc atgtccatgg gggcccttac cgacctggga 21060
cagaacatgc tctatgccaa ctcagcccat gcgctggaca tgacttttga ggtggatccc 21120
atggatgagc ccaccctgct ttatcttctt ttcgaagtct tcgacgtggt cagagtgcac 21180
cagccacacc gcggcgtcat cgaggccgtc tacctgcgca caccgttctc ggccggcaac 21240
gccaccacat aagaagcctc ttgcttcttg caagcagcag ctgcagccat gacatgcggg 21300
tccggaaacg gctccagcga gcaagagctc aaagccatcg tccgagacct gggctgcgga 21360
ccctatttcc tgggaacctt tgacaagcgt ttcccggggt tcatggcccc cgacaagctc 21420
gcctgcgcca tagtcaacac tgccggacgc gagacggggg gagagcactg gctggctttt 21480
ggttggaacc cgcgctacaa cacctgctac ctttttgatc cttttgggtt ctcggatgag 21540
cggctcaaac agatttacca gtttgagtac gaggggctcc tgcgtcgcag tgcccttgct 21600
accaaagacc gctgcatcac cctggagaag tctacccaaa gcgtgcaggg tccgcgctca 21660
gccgcctgtg gacttttttg ctgtatgttc cttcatgcct ttgtgcactg gcccgaccgc 21720
cccatggacg gaaaccccac catgaagttg ctgactgggg tgtccaacag catgctccaa 21780
tcaccccaag tccagcccac cctgcgccgc aaccaggagg tgctataccg cttcctaaac 21840
acccactcat cttactttcg ttctcaccgc gcgcgcattg aaagggccac cgcgtttgac 21900
cgtatggata tgcaataagt catgtaaaac cgtgttcaat aaacagcact ttatttttac 21960
atgcactgag gctctggttt tgctcatttg tttcatcatt tactcagaag tcgaatgggt 22020
tctggcggga gtcagagtga cccgcgggca gggatacgtt gcggaactgt aacctgttct 22080
gccacttgaa ctcggggatt accagcttgg gaactggaat ctcgggaaag gtgtcttgcc 22140
acaactttct ggtcagttgc atagcgccaa gcaggtcagg agcagagatc ttgaaatcac 22200
agttggggcc ggcattctgg acacgggagt tgcgatacac tgggttgcaa cactggaaca 22260
ctatcaacgc tgggtgtctt acgcttgcca acacggttgg gtcactgatg gtagtcacat 22320
ccaagtcttc agcattggcc atcccaaagg gggtcatctt acatgtctgc ctgcccatca 22380
cgggagcgca gcctggcttg tggttgcaat cacaatgaat ggggatcagc atcatcctgg 22440
cttggtcggg agttatccct gggtacacag ccttcatgaa ggcttcgtac tgcttaaaag 22500
cttcctgggc cttacttccc tcggtgtaga acatcccaca ggacttgctg gaaaattgat 22560
tagtagtaca gttggcatca ttcacacaac agcgggcatc gttgttggcc aactgaacca 22620
catttctgcc ccagcggttt tgggtgatct tggctctgtc tggattctcc ttcatagcgc 22680
gctgcccgtt ctcgctcgcc acatccatct cgataatgtg gtccttctgg atcatgatag 22740
tgccatgcag gcatttcacc ttgccttcat aatcggtgca tccatgagcc cacagagcgc 22800
acccggtgca ctcccaatta ttgtgggcga tctcagaata ataatgtacc aatccctgca 22860
tgaatcttcc catcattgtt gtcaaggtct tcatgctggt aaatgtcagc gggatgccac 22920
ggtgctcctc gttcacatac tggtggcaga tacgcttgta ttgctcgtgc tgctctggca 22980
tcagcttgaa agaggttctc agatcattat ccagcctgta cctttccatt agcacagcca 23040
tcacttccat gcccttctcc caggcagata ccaggggcag actcaaagga ttcctaacag 23100
caataaaagt agctccttta gctatagggt cattcttgtc gatcttctca acacttctct 23160
tgccatcctt ctcaatgatg cgcaccgggg ggtagctgaa gcccacggcc accaactgag 23220
cctgttctct ttcttcttca ctatcctggc tgatgtcttg cagagggaca tgcttggtct 23280
tcctgggctt cttcttggga gggatcgggg gaggactgtt gctccgctcc ggagacaggg 23340
atgactgcga agtttcgctt accaatacca cctggctctc ggtagaagaa ccggacccca 23400
cacgacggta ggtgttcctc ttcgggggca gaggtggagg cgactgagat gggctgcggt 23460
ctggccttgg aggcggatgg ctggcagagc tcattccgcg ttcgggggtg tgctcccggt 23520
ggcggtcgct tgactgattt cctccgcggc tggccattgt gttctcctag gcagagaaac 23580
aacagacatg gaaactcagc catcactgcc aacatcgctg caagcaccat cacacctcgc 23640
ccccagcagc gacgaggagg agagcttaac caccccacca cccagtcccg ctaccaccac 23700
ctctaccctc gatgatgagg aggaggtcga cgcagcccag gagatgcagg cgcaggataa 23760
tgtgaaaacg gaagagattg aggcagatgt cgagcaggac ccgggctatg tgacgccggc 23820
ggagcaccag gaggagctga aacgctttct agacagagag gatgacgacc gcccagagca 23880
tcaagcagat ggcgtttacc aggaggctgg gatcagggat catgtcgccg actacctcac 23940
cggccttggt ggggaggacg tgctcctcaa acatctagca aggcagtcga tcatagttaa 24000
agacgcattg ctcgatctca ctgaagtgcc catcagtgtg gaagagctta gccgcgccta 24060
cgagctgaac ctcttttcgc ctcaggtacc ccccaagcgg cagccaaacg gcacctgcga 24120
ggccaaccct cgactcaact tctatccagc ttttactatc cccgaagtgt tggccaccta 24180
ccacatcttt ttcaagaacc aaaagattcc agtctcctgc cgcgccaacc gcacccgcgc 24240
cgatgccctg ctcaacttgg gtccgggagc tcgcttacct gatatagctt ccttggaaga 24300
ggttccaaag atctttgagg gtctgggaag tgatgagaca cgggccgcaa atgctctgca 24360
acagggagag aatgacatgg atgaacacca cagcgctctg gtggaactgg agggtgacaa 24420
tgcccggatt gcagtgctca agcgcagtat cgtggtcacc cattttgcct accccgctgt 24480
taacctgccc cccaaagtta tgagcgctgt catggaccat ctgctcatca aacgagcaag 24540
acctctttca gaaaaccaga acatgcagga tccagacgcc tcggacgagg gcaagccggt 24600
agtcagtgac gagcagctat ctcgctggct gggtaccaac tccccccgag atttggaaga 24660
gaggcgcaag cttatgatgg ctgtagtgct agtaactgtg gagctggagt gtctgcgccg 24720
ctttttcacc gaccctgaga ccctgcgcaa gctagaggag aacctgcact acacctttag 24780
acatggcttc gtgcggcagg catgcaagat ctccaacgtg gagcttacca acctggtttc 24840
ttacatgggc attttgcatg agaaccgact agggcagagc gtcctgcaca ccacccttaa 24900
aggggaggcc cgccgtgact acatccgaga ctgtgtctac ctctacctct gccatacctg 24960
gcaaactggt atgggtgtgt ggcaacagtg tttggaagag cagaacctaa aagagctgga 25020
caagctcttg cagagatccc tcaaagccct gtggacaggt tttgatgagc gcaccgtcgc 25080
ctcggacctg gcagacatca tcttccccga gcgtctcagg gttactctgc gaaacggcct 25140
gccagacttt atgagccaga gcatgcttaa caactttcgc tctttcatcc tggaacgctc 25200
cggtatcctg cctgccacct gctgtgcgct gccctccgac tttgtgcctc tcacctaccg 25260
cgagtgccca ccgccgctat ggagccactg ctacctgttc cgcctggcca actacctctc 25320
ctaccactcg gatgttatag aggatgtgag cggagacggc ctgctggaat gccactgccg 25380
ctgcaatctt tgcacacccc accgctccct tgcctgcaac ccccagttgc tgagcgagac 25440
ccagattatc ggcaccttcg agctgcaggg tcccagaagt aaaggcgagg ggtcttctcc 25500
ggggcagagt ttgaaactga caccggggct gtggacctcc gcctacctgc gcaagtttca 25560
ccccgaggac taccatccct atgagatcag gttctatgag gaccaatcac atcctcccaa 25620
agtcgagctc tcagcctgcg tcatcaccca gggagcaatt ctggcccaat tgcaagccat 25680
ccaaaaatct cgccaagaat ttctgctaaa aaagggaaac ggggtctacc ttgaccctca 25740
gaccggtgag gagctcaaca caaggttccc ccaggatgtc ccatcgccga ggaagcaaga 25800
agttgaaggt gcagctgtcg cccccagagg atatgaagga agactgggac agtcaggcag 25860
aggaggagat ggaagattgg gacagccagg cagaggaggt ggacagcctg gaggaagaca 25920
gtttggagga ggaagacgag gaggcagagg aggtggaaga agcaaccgcc gccaaacagt 25980
tgtcatcggc ggcggagaca agcaagtccc cagacagcag cacggctacc atctccgctc 26040
cgggtcgggg ggcccagcgg cggcccaaca gtagatggga cgagaccggg cgattcccaa 26100
acccgaccac cgcttccaag accggtaaga aggagcgaca gggatacaag tcctggcgtg 26160
gacataaaaa cgctatcatc tcctgcttgc atgaatgcgg gggcaacata tccttcaccc 26220
ggcgatacct gctcttccac cacggtgtaa acttcccccg caatatcttg cattactacc 26280
gtcacctcca cagcccctac tgcagtcagc aagtcccggc aaccccgaca gaaaaataca 26340
gcagcgacaa cggtgaccag aaaaccagca gttagaaaat ccacaacaag tgcaccagga 26400
ggaggactga ggatcacagc gaacgagcca gcgcagacca gagagctgag gaaccggatc 26460
tttccaaccc tctatgccat tttccagcag agtcgggggc aagagcagga actgaaagta 26520
aaaaaccgat ctctgcgctc gctcaccaga agttgtttgt atcacaagag cgaagaccaa 26580
cttcagcgca ctctcgagga cgccgaggct ctcttcaaca agtactgcgc gctgactctt 26640
aaagagtagc ccttgcccgc gctcattttg aaaacggcgg gaatcacgtc acccttggca 26700
cctgtccttt gcccttgtca tgagtaaaga gattcccacg ccttacatgt ggagctatca 26760
gccccaaatg gggttggcag caggcgcttc ccaggactac tccacccgca tgaattggct 26820
tagcgccggg ccctcaatga tatcacgggt taatgatata cgagcttatc gaaaccagtt 26880
actcctagaa cagtcagctc tcaccaccac accccgtcaa caccttaatc cccgaaattg 26940
gcccgccacc ctggtgtacc aggaaaatcc cgctcccacc accgtactac ttcctcgaga 27000
cgcccaggcc gaagttcaga tgactaacgc aggtgtacag ctggcgggcg gttccgccct 27060
atgtcgtcac cgacctcaac agagtataaa acgcctggtg attagaggcc gaggtatcca 27120
gctcaacgac gagtcggtta gctcttcgct tggtctgcga ccagacggag tcttccaaat 27180
cgccggctgt gggagatctt ccttcactcc tcgtcaggct gtgctgactt tggagagttc 27240
gtcctcgcag ccccgctcgg gcggcattgg aactctccag tttgtggagg agtttactcc 27300
ctctgtctac ttcaacccct tctccggctc tcctggccag tacccggacg agttcatacc 27360
aaacttcgac gcaatcagcg agtcagtgga tggctatgat tgatgtctaa tggtggtgcg 27420
gctgagctag ctcgactgcg acacctagac cactgccgcc gctttcgctg cttcgcccgg 27480
gaactcaccg agttcatcta cttcgaactc tccgaggagc accctcaggg tccggcccac 27540
ggagtgcgga ttaccatcga agggggaata gactctcgcc tgcatcgcat cttctcccag 27600
cggcccgtgc taattgaacg cgaccaggga aatacaacca tctccatcta ctgcatctgt 27660
aaccaccccg gattgcatga aagcctttgc tgtcttgttt gtgctgagtt taataaaaac 27720
tgagttaaga ccctcctacg gactaccgct tcttcaatca ggactttaca acaccaacca 27780
gatcttccag aagacccaga cccttcctcc tttcatccag gactctaact ctaccttacc 27840
agcaccctcc actactaacc ttcccgaaac aaacaagctt gcatctcatc tgcaacaccg 27900
cctttcacga agccttcttt ctgccaatac taccactccc aaaaccggag gtgagctccg 27960
cggtcttcct actgacgacc cctgggtggt agcgggtttt gtaacgttag gagtagttgc 28020
gggtgggctt gtgctgatcc tttgctacct atacacacct tgctgtgcat atttagtcat 28080
attgtgctgt tggtttaaga aatgggggcc atactagtcg tgcttgcttt actttcgctt 28140
ttgggtctgg gctctgctaa tctcaatcct ctcgatcacg atccatgttt agacttcgac 28200
ccagaaaact gcacacttac ttttgcaccc gacacaagcc gtctctgtgg agttcttatt 28260
aagtgcggat gggactgcag gtccgttgaa attacacata ataacaaaac atggaacaat 28320
accttatcca ccacatggga gccaggagtt ccccagtggt atactgtctc tgtccgaggt 28380
cctgacggtt ccatccgcat tagtaacaac actttcattt tttctgaaat gtgcgatctg 28440
gccatgttca tgagcagaca gtatgaccta tggcctccca gcaaagagaa cattgtggca 28500
ttttccattg cttattgctt ggtaacatgc atcatcactg ctatcatttg tgtgtgcata 28560
cacttgctta tagttattcg ccctagacaa agcaatgagg aaaaagagaa aatgccttaa 28620
cctttttcct catacctttt ctttacagca tggcttctgt tacagctcta attattgcca 28680
gcattgtcac tgtcgctcac gggcaaacaa ttgtccatat taccttagga cataatcaca 28740
ctcttgtagg gcccccaatt acttcagagg ttatttggac caaacttgga agtgttgatt 28800
attttgatat aatttgcaac aaaactaaac caatatttgt aatctgtaac agacaaaatc 28860
tcacgttaat taatgttagc aaaatttata acggttacta ttatggttat gacagatcca 28920
gtagtcaata taaaaattac ttagttcgca taactcagcc caaattaaca gtgccaacta 28980
tgacaataat taaaatggct aataaagcat tagaaaattt tacatcacca acaacaccca 29040
atgaaaaaaa cattccaaat tcaatgattg caattattgc ggcggtggca ttgggaatgg 29100
cactaataat aatatgcatg ctcctatatg cttgttacta taaaaagttt caacataaac 29160
aggatccact actaaatttt aacatttaat tttttataca gatgatttcc actacaattt 29220
ttatcattac tagccttgca gctgtaactt atggccgttc acacctaact gtacctgttg 29280
gctcaacatg tacactacaa ggaccccaag aaggctatgt cacttggtgg agaatatatg 29340
ataatggagg gttcgctaga ccatgtgatc agcctggtac aaaattttca tgcaacggaa 29400
gagacttgac cattattaac ataacatcaa atgagcaagg cttctattat ggaaccaact 29460
ataaaaatag tttagattac aacattattg tagtgccagc caccacttct gctccccgca 29520
aatccacttt ctctagcagc agtgccaaag caagcacaat tcctaaaaca gcttctgcta 29580
tgttaaagct tccaaaaatc gctttaagta attccacagc cgctcccaat acaattccta 29640
aatcaacaat tggcatcatt actgccgtgg tagtgggatt aatgattata tttttgtgta 29700
taatgtacta cgcctgctgc tatagaaaac atgaacaaaa aggtgatgca ttactaaatt 29760
ttgatattta attttttata gaattatgat attgtttcaa tcaaatacca ctacctccta 29820
tgcatacaca aacattcagc ctaaatacgc tatgcaacta gaaatcacaa tactaattgt 29880
aattggaatt cttatactat ctgttattct ttattttata ttctgccgtc aaatacccaa 29940
tgttcataga aattctaaaa gacgtcccat ctattctcct atgattagtc gtccccatat 30000
ggctctgaat gaaatctaag atcttttttt ttttctctta cagtatggtg aacatcaatc 30060
atgatcccta gaaatttctt cttcaccata ctcatctgtg cttttaatgt ctgtgctact 30120
ttcacagcag tagccactgc aagcccagac tgtataggac catttgcttc ctatgcactt 30180
tttgccttcg ttacttgcat ctgcgtgtgt agcatagtct gcctggttat taattttttc 30240
caactggtag actggatctt tgtgcgaatt gcctacctac gtcaccatcc cgaataccgc 30300
aatcaaaatg ttgcggcact tcttaggctt atttaaaacc atgcaggcta tgctaccagt 30360
cattttaatt ttgctactac cctgcattcc cctagcttcc accgccactc gcgctacacc 30420
tgaacaactt agaaaatgca aatttcaaca accatggtca tttcttgatt gctaccatga 30480
aaaatctgat tttcccacat actggatagt gattgttgga ataattaaca tactttcatg 30540
tacctttttc tcaatcacaa tataccccac atttaatttt gggtggaatt ctcccaatgc 30600
actgggttac ccacaagaac cagatgaaca tattccacta caacacatac aacaaccact 30660
agcactggta cagtatgaaa atgagccaca accttcactg ccccctgcca ttagttactt 30720
caacctaacc ggcggagatg actgacccaa tcgccacatc atccaccgct gccaaggagc 30780
tgctggacat ggacggacgt gcctcagaac agcgactcat ccaactacgc attcgtcagc 30840
agcaggaacg agcagtaaaa gagctaaggg atgccattgg gattcaccag tgcaaaaaag 30900
gcatattctg cttagtaaaa caatccaaaa tctcctacga gatcaccgct actgaccatc 30960
gtctctcata cgagctcggt ccgcagcgac aaaaattcac ctgcatggtg ggaatcaacc 31020
ccatagttat cacccagcag tctggagata ctaagggttg tatccagtgt tcctgtgatt 31080
ccaccgagtg catctacaca ctgctgaaga ccctctgcgg ccttcgagac ctcctaccca 31140
tgaactaatc attgccccta ccttacccaa tcaaaatatt aataaagaca cttacttgaa 31200
atcagcaata cagtctttgt caaaactttc taccagcagc acctcaccct cttcccaact 31260
ctggtactct aaacgtcgga gggtggcata ctttctccac actttgaaag ggatgtcaaa 31320
ttttatttcc tcttctttgc ccacaatctt catttcttta tccccagatg gccaagcgag 31380
ctcggctaag cacttccttc aacccggtgt acccttatga agatgaaagc agctcacaac 31440
acccatttat aaatcctggt ttcatttccc ctgacgggtt cacacaaagt ccaaacgggg 31500
ttttaagtct taaatgtgtt aatccactta ccactgcaag cggctccctc caacttaaag 31560
tgggaagtgg tcttacagta gacactactg atggatcctt agaagaaaac atcaaagtta 31620
acacccccct aacaaagtca aaccattcta taaatttacc aataggaaac ggtttgcaaa 31680
tagaacaaaa caaactttgc agtaaactcg gaaatggtct tacatttgac tcttccaatt 31740
ctattgcact gaaaaataac actttatgga caggtccaaa accagaagcc aactgcataa 31800
ttgaatacgg gaaacaaaac ccagatagca aactaacttt aatccttgta aaaaatggag 31860
gaattgttaa tggatatgta acgctaatgg gagcctcaga ctacgttaac accttattta 31920
aaaacaaaaa tgtctccatt aatgtagaac tatactttga tgccactggt catatattac 31980
cagactcatc ttctcttaaa acagatctag aactaaaata caagcaaacc gctgacttta 32040
gtgcaagagg ttttatgcca agtactacag cgtatccatt tgtccttcct aatgcgggaa 32100
cacataatga aaattatatt tttggtcaat gctactacaa agcaagcgat ggtgcccttt 32160
ttccgttgga agttactgtt atgcttaata aacgcctgcc agatagtcgc acatcctatg 32220
ttatgacttt tttatggtcc ttgaatgctg gtctagctcc agaaactact caggcaaccc 32280
tcataacctc cccatttacc ttttcctata ttagagaaga tgactgacaa caaaaataaa 32340
gttcaacatt ttttattgaa attcctttta cagtattcga gtagttattt tgcctccccc 32400
ttcccattta acagaataca ccaatctctc cccacgcaca gctttaaaca tttggatacc 32460
attagagata gacatagttt tagattccac attccaaaca gtttcagagc gagccaatct 32520
ggggtcagta atacataaaa atgcatcggg atagtctttt aaagcgcttt cacagtccaa 32580
ctgttgcgga tgcgactccg gagtctgaat cacggtcatc tggaagaaga acgatgggaa 32640
tcataatccg aaaacggaat cgggcgattg tgtctcatca aacccacaag caaccgctgt 32700
ctgcgtcgct ccgtgcgact gctgtttatg ggatcggggt ccgcagtgtc ctgaagcatg 32760
attttaatag cccttaacat taactttctg gtgcgatgcg cgcagcaacg cattctgatt 32820
tcacttagat tactacagta ggtacagcac attatcacaa tattgtttaa taaaccataa 32880
ttaaaagcgc tccagccaaa actcatatct gatataatcg cccctgcatg accatcatac 32940
caaagtttaa tataaattaa atgtcgttcc ctcaaaaaca cactacccac atacatgatc 33000
tcttttggca tgtgcatatt aacaatttgt ctgtaccatg gacaacgttg gttaatcatg 33060
caacccaata taaccttccg gaaccacact gccaacaccg ctcccccagc catgcattga 33120
agtgaaccct gctgattaca atgacaatga agaacccaat tctctcgacc atgaatcact 33180
tgagactgaa aaatatctat agtagcacaa caaagacata aatgcatgca tcttctcata 33240
atttttaact cctctggatt taaaaacata tcccaaggaa tgggaaactc ttgcagaaca 33300
gtaaagctgg cagaacaagg aagaccacga acacaactta cactatgcat agtcatagta 33360
tcacaatctg gcaacagcgg gtggtcttca gtcatagaag ctcgggtttc attttcctca 33420
catcgtggta attgggctct ggtgtaaggg tgatgtctgg cgcatgatgt ggagcgtgcg 33480
cgcaaccttg tcataatgga gttgcttcct gacattctcg tattttgtat agcaaaacgc 33540
tgccctggca caacacactc ttcttcgtct tctatcctgc cgcttagtgt gttccgtctg 33600
ataattcaag tacagccaca ctcttaagtt ggtcaaaaga atgctggctt cagttgtaat 33660
caaaactcca tcatatttaa ttgttctaag gaaatcatcc acggtagcat atgcaaatcc 33720
caaccaagca atgcaactgg attgcgtttc aagcagcaga ggagagggaa gagacggaag 33780
aatcatgtta atttttattc caaacgatct cgcagtactt caaattgtag atcgcgcaga 33840
tggcatctat cgcccccact gtgttggtga aaaagcacag ctaaatcaaa agaaatgcga 33900
ttttcaaggt gctcaacggt ggcttccaac aaagcctcca cgcgcacatc caaaaacaaa 33960
agaataccaa aagaaggagc attttctaac tcctcaaaca tcatattaca ttcctgcacc 34020
attcccagat aattttcagc tttccagcct tgaattattc gtgtcagttc ttgtggtaaa 34080
tccaaaccac acattacaaa caggtcccgg agggcgccct ccaccaccat tcttaaacac 34140
accctcataa tgacaaaata tcttgctcct gtgtcacctg tagcaaatta agaatggcat 34200
catcaattga catgcccttg gctctaagtt cttctctaag ttctagttgt agatactctc 34260
tcatattatc accaaactgc ttagccagaa gccccccggg aacaatagca ggggacgcta 34320
cagtgcagta caagcgcaga cctccccaat tggctccagc aaaaacaaga ttagaataag 34380
catactggga accaccagta atatcatcaa agttgctgga aatataatca ggcagagttt 34440
cttgtaaaaa ttgaataaaa gaaaaatttt ccaaagaaac attcaaaacc gttgggatgc 34500
aaatacaata ggttaccgcg ctgcgctcca acattgttag ttttgaatta gtctgcaaaa 34560
taaaagaaac aagcgtcata tcatagtagc ctgtcgaaca ggtggaaaaa tcagtctttc 34620
catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt cattgtgatt 34680
aaacaacagc accgaaagtt cctcgcggtg gccagcatga ataattcttg atgaagcata 34740
caatccagac atgttagcat cagttaaaga gaaaaaacag ccaacatagc ctctgggtat 34800
aattatgctt aattttaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34860
aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgttg ctcccggtcc 34920
ctctaaatag acatacaaag cctcatcagc catggcttac caggcaaagt acagcgggcg 34980
cacaaagcac aagctctaaa gaagctctaa aaacactctc caacctctcc acaatatata 35040
cacaagccct aaactgacgt aatgggagta aagtgaaaaa aaaataccgc caagcccaac 35100
acacaccccg aaactgcgtc agcaggaaaa agtacagttt cacttccgca ttcccaacaa 35160
gcgtaacttc ctctttctca tggtacgtca catccgatta acttgcaacg tcattttccc 35220
acggtcgcgc cgcccctttt agccgttaac cccgcagcca atcaccacac agcgcgcact 35280
tttttaaatt acctcattta catgttggca ccattccatc tataaggtat attatataga 35340
tagcctccgg ggtccactgc aattacggtg cgcgcgatgc attcgaagat ctgcccacta 35400
gtgagtcgta ttacgtagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg 35460
ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg 35520
tgcctaatga gtgagctaac tcacattaca tgtgagcaaa aggccagcaa aaggccagga 35580
accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc 35640
acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg 35700
cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat 35760
acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt 35820
atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc 35880
agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg 35940
acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg 36000
gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg 36060
gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg 36120
gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca 36180
gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga 36240
acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga 36300
tccttttacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc 36360
gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt 36420
ctcgccacgt tcgctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 36480
ttagtgcttt acggcacctc gaccccaaaa aacttgattt gggtgatggt tcacgtagtg 36540
ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 36600
gtggactctt gttccaaact ggaacaacac tcaaccctat ctcgggctat tcttttgatt 36660
tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 36720
ttaacgcgaa ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct 36780
tcctgttttt ggggcttttc tgattatcaa ccggggtaaa tcaatctaaa gtatatatga 36840
gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg 36900
tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga 36960
gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc 37020
agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac 37080
tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc 37140
agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc 37200
gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc 37260
catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt 37320
ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc 37380
atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg 37440
tatgcggcga ccgagttgct cttgcccggc gtcaacacgg gataataccg cgccacatag 37500
cagaacttta aaagtgctca tcattggaga acgttcttcg gggcgaaaac tctcaaggat 37560
cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc 37620
atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa 37680
aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta 37740
ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa 37800
aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtagttaa 37860
caaaaaaaag cccgccgaag cgggctttat taccaagcga agcgccattc gccattcagg 37920
ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctggcg 37980
aaagggggat gtgctgcaag gcgattaagt tgggtaacgc cagggttttc ccagtcacga 38040
cgttgtaaaa cgacggccag tccgtaatac gactcactta aggccttgac tagagggtac 38100
ctaattgcag tggaccccgg agg 38123
<210> 45
<211> 36071
<212> DNA
<213> 人工序列
<220>
<223> pAC05-CE1
<400> 45
cggtgcgcgc gatgcattcg aagatctgcc cactagtgag tcgtattacg tagcttggcg 60
taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac 120
atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca 180
ttacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc 240
gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag 300
gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt 360
gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg 420
aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg 480
ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg 540
taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac 600
tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg 660
gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt 720
taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg 780
tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc 840
tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt 900
ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttacgcgccc tgtagcggcg 960
cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc 1020
tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgct ttccccgtca 1080
agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 1140
caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 1200
tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 1260
aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc cgatttcggc 1320
ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt 1380
aacgtttaca atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt 1440
atcaaccggg gtaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa 1500
tgtatcgttt cagacccacc tcccaacccc gaggggaccc agagagggcc tatttcccat 1560
gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta gaattaattt 1620
gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg 1680
gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta ccgtaacttg 1740
aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca cctaattgca 1800
gtggaccccg ggttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa 1860
cttgaaaaag tggcaccgag tcggtgcttt tttaagcttg aattgtaact ttaaataatt 1920
ggcattattt aaagttagaa tttctgccat tcatccgctt attatcactt attcaggcgt 1980
agcaaccagg cgtttaaggg caccaataac tgccttaaaa aaattacgcc ccgccctgcc 2040
actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag ccatcacaga 2100
cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc gtataatatt 2160
tgcccatggt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt aaatcaaaac 2220
tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata aaccctttag 2280
ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg tgtagaaact 2340
gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt tgctcatgga 2400
aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct ttcattgcca 2460
tacggaattc cggatgagca ttcatcaggc gggcaagaat gtgaataaag gccggataaa 2520
acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc tgaacggtct 2580
ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta cgatgccatt 2640
gggatatatc aacggtggta tatccagtga tttttttctc cattttagct tccttagctc 2700
ctgaaaatct cgataactca aaaaatacgc ccggtagtga tcttatttca ttatggtgaa 2760
agttggaacc tcttacgtgc cgatcaacgt ctcattttcg ccaaaagttg gcccagggct 2820
tcccggtatc aacagggaca ccaggattta tttattctgc gaagtgatct tccgtcacag 2880
gtatttattc gcgataagct catggagcgg cgtaaccgtc gcacaggaag gacagagaaa 2940
gcggtaccta ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tagttaacaa 3000
aaaaaagccc gccgaagcgg gctttattac caagcgaagc gccattcgcc attcaggctg 3060
cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca gctggcgaaa 3120
gggggatgtg ctgcaaggcg attaagttgg gtaacgccag ggttttccca gtcacgacgt 3180
tgtaaaacga cggccagtcc gtaatacgac tcacttaagg ccttgactag agggtaccta 3240
attgcagtgg accccggagg catcatcaat aatatacctt attttggatt gaagccaata 3300
tgataatgag ggggtggagt ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg 3360
tagtagtgtg gcggaagtgt gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg 3420
tggcaaaagt gacgtttttg gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg 3480
gttttaggcg gatgttgtag taaatttggg cgtaaccgag taagatttgg ccattttcgc 3540
gggaaaactg aataagagga agtgaaatct gaataatttt gtgttactca tagcgcgtaa 3600
taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca 3660
taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 3720
ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg 3780
gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg 3840
ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc 3900
ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg 3960
atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca 4020
agtctccacc ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt 4080
ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg 4140
gaggtctata taagcagagc tggtttagtg aaccgtcaga tccgctagcg ctaccggtcg 4200
ccaccatggt gagcaagggc gaggaggata acatggccat catcaaggag ttcatgcgct 4260
tcaaggtgca catggagggc tccgtgaacg gccacgagtt cgagatcgag ggcgagggcg 4320
agggccgccc ctacgagggc acccagaccg ccaagctgaa ggtgaccaag ggtggccccc 4380
tgcccttcgc ctgggacatc ctgtcccctc agttcatgta cggctccaag gcctacgtga 4440
agcaccccgc cgacatcccc gactacttga agctgtcctt ccccgagggc ttcaagtggg 4500
agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt gacccaggac tcctccctgc 4560
aggacggcga gttcatctac aaggtgaagc tgcgcggcac caacttcccc tccgacggcc 4620
ccgtaatgca gaagaagacc atgggctggg aggcctcctc cgagcggatg taccccgagg 4680
acggcgccct gaagggcgag atcaagcaga ggctgaagct gaaggacggc ggccactacg 4740
acgctgaggt caagaccacc tacaaggcca agaagcccgt gcagctgccc ggcgcctaca 4800
acgtcaacat caagttggac atcacctccc acaacgagga ctacaccatc gtggaacagt 4860
acgaacgcgc cgagggccgc cactccaccg gcggcatgga cgagctgtac aagtccggac 4920
tcagatctcg agctcaagct tcgaattctg cagtcgacgg taccgcgggc ccgggatcca 4980
ccggatctag ataactgatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt 5040
taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 5100
ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 5160
caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 5220
cttaaatcga attcaagctt gtcgactcga agatctgagc tcacgcgtga agttcctatt 5280
ctctagaaag tataggaact tcagagcgct tttgaagctg gggtgggcga agaactccag 5340
catgagatcc ccagagcgct tttgaagctg cgtttaaacg cgatatcccg ggagctcccg 5400
atatcgcgtt taaacgcagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt 5460
gttatccgct cacaattcca cacaacatac gagccggaag actgaaatgt gtgggcgtgg 5520
cttaagggtg ggaaagaata tataaggtgg gggtcttatg tagttttgta tctgttttgc 5580
agcagccgcc gccgccatga gcaccaactc gtttgatgga agcattgtga gctcatattt 5640
gacaacgcgc atgcccccat gggccggggt gcgtcagaat gtgatgggct ccagcattga 5700
tggtcgcccc gtcctgcccg caaactctac taccttgacc tacgagaccg tgtctggaac 5760
gccgttggag actgcagcct ccgccgccgc ttcagccgct gcagccaccg cccgcgggat 5820
tgtgactgac tttgctttcc tgagcccgct tgcaagcagt gcagcttccc gttcatccgc 5880
ccgcgatgac aagttgacgg ctcttttggc acaattggat tctttgaccc gggaacttaa 5940
tgtcgtttct cagcagctgt tggatctgcg ccagcaggtt tctgccctga aggcttcctc 6000
ccctcccaat gcggtttaaa acataaataa aaaaccagac tctgtttgga tttggatcaa 6060
gcaagtgtct tgctgtcttt atttaggggt tttgcgcgcg cggtaggccc gggaccagcg 6120
gtctcggtcg ttgagggtcc tgtgtatttt ttccaggacg tggtaaaggt gactctggat 6180
gttcagatac atgggcataa gcccgtctct ggggtggagg tagcaccact gcagagcttc 6240
atgctgcggg gtggtgttgt agatgatcca gtcgtagcag gagcgctggg cgtggtgcct 6300
aaaaatgtct ttcagtagca agctgattgc caggggcagg cccttggtgt aagtgtttac 6360
aaagcggtta agctgggatg ggtgcatacg tggggatatg agatgcatct tggactgtat 6420
ttttaggttg gctatgttcc cagccatatc cctccgggga ttcatgttgt gcagaaccac 6480
cagcacagtg tatccggtgc acttgggaaa tttgtcatgt agcttagaag gaaatgcgtg 6540
gaagaacttg gagacgccct tgtgacctcc aagattttcc atgcattcgt ccataatgat 6600
ggcaatgggc ccacgggcgg cggcctgggc gaagatattt ctgggatcac taacgtcata 6660
gttgtgttcc aggatgagat cgtcataggc catttttaca aagcgcgggc ggagggtgcc 6720
agactgcggt ataatggttc catccggccc aggggcgtag ttaccctcac agatttgcat 6780
ttcccacgct ttgagttcag atggggggat catgtctacc tgcggggcga tgaagaaaac 6840
ggtttccggg gtaggggaga tcagctggga agaaagcagg ttcctgagca gctgcgactt 6900
accgcagccg gtgggcccgt aaatcacacc tattaccggg tgcaactggt agttaagaga 6960
gctgcagctg ccgtcatccc tgagcagggg ggccacttcg ttaagcatgt ccctgactcg 7020
catgttttcc ctgaccaaat ccgccagaag gcgctcgccg cccagcgata gcagttcttg 7080
caaggaagca aagtttttca acggtttgag accgtccgcc gtaggcatgc ttttgagcgt 7140
ttgaccaagc agttccaggc ggtcccacag ctcggtcacc tgctctacgg catctcgatc 7200
cagcatatct cctcgtttcg cgggttgggg cggctttcgc tgtacggcag tagtcggtgc 7260
tcgtccagac gggccagggt catgtctttc cacgggcgca gggtcctcgt cagcgtagtc 7320
tgggtcacgg tgaaggggtg cgctccgggc tgcgcgctgg ccagggtgcg cttgaggctg 7380
gtcctgctgg tgctgaagcg ctgccggtct tcgccctgcg cgtcggccag gtagcatttg 7440
accatggtgt catagtccag cccctccgcg gcgtggccct tggcgcgcag cttgcccttg 7500
gaggaggcgc cgcacgaggg gcagtgcaga cttttgaggg cgtagagctt gggcgcgaga 7560
aataccgatt ccggggagta ggcatccgcg ccgcaggccc cgcagacggt ctcgcattcc 7620
acgagccagg tgagctctgg ccgttcgggg tcaaaaacca ggtttccccc atgctttttg 7680
atgcgtttct tacctctggt ttccatgagc cggtgtccac gctcggtgac gaaaaggctg 7740
tccgtgtccc cgtatacaga cttgagaggc ctgtcctcga gcggtgttcc gcggtcctcc 7800
tcgtatagaa actcggacca ctctgagaca aaggctcgcg tccaggccag cacgaaggag 7860
gctaagtggg aggggtagcg gtcgttgtcc actagggggt ccactcgctc cagggtgtga 7920
agacacatgt cgccctcttc ggcatcaagg aaggtgattg gtttgtaggt gtaggccacg 7980
tgaccgggtg ttcctgaagg ggggctataa aagggggtgg gggcgcgttc gtcctcactc 8040
tcttccgcat cgctgtctgc gagggccagc tgttggggtg agtactccct ctgaaaagcg 8100
ggcatgactt ctgcgctaag attgtcagtt tccaaaaacg aggaggattt gatattcacc 8160
tggcccgcgg tgatgccttt gagggtggcc gcatccatct ggtcagaaaa gacaatcttt 8220
ttgttgtcaa gcttggtggc aaacgacccg tagagggcgt tggacagcaa cttggcgatg 8280
gagcgcaggg tttggttttt gtcgcgatcg gcgcgctcct tggccgcgat gtttagctgc 8340
acgtattcgc gcgcaacgca ccgccattcg ggaaagacgg tggtgcgctc gtcgggcacc 8400
aggtgcacgc gccaaccgcg gttgtgcagg gtgacaaggt caacgctggt ggctacctct 8460
ccgcgtaggc gctcgttggt ccagcagagg cggccgccct tgcgcgagca gaatggcggt 8520
agggggtcta gctgcgtctc gtccgggggg tctgcgtcca cggtaaagac cccgggcagc 8580
aggcgcgcgt cgaagtagtc tatcttgcat ccttgcaagt ctagcgcctg ctgccatgcg 8640
cgggcggcaa gcgcgcgctc gtatgggttg agtgggggac cccatggcat ggggtgggtg 8700
agcgcggagg cgtacatgcc gcaaatgtcg taaacgtaga ggggctctct gagtattcca 8760
agatatgtag ggtagcatct tccaccgcgg atgctggcgc gcacgtaatc gtatagttcg 8820
tgcgagggag cgaggaggtc gggaccgagg ttgctacggg cgggctgctc tgctcggaag 8880
actatctgcc tgaagatggc atgtgagttg gatgatatgg ttggacgctg gaagacgttg 8940
aagctggcgt ctgtgagacc taccgcgtca cgcacgaagg aggcgtagga gtcgcgcagc 9000
ttgttgacca gctcggcggt gacctgcacg tctagggcgc agtagtccag ggtttccttg 9060
atgatgtcat acttatcctg tccctttttt ttccacagct cgcggttgag gacaaactct 9120
tcgcggtctt tccagtactc ttggatcgga aacccgtcgg cctccgaacg gtaagagcct 9180
agcatgtaga actggttgac ggcctggtag gcgcagcatc ccttttctac gggtagcgcg 9240
tatgcctgcg cggccttccg gagcgaggtg tgggtgagcg caaaggtgtc cctgaccatg 9300
actttgaggt actggtattt gaagtcagtg tcgtcgcatc cgccctgctc ccagagcaaa 9360
aagtccgtgc gctttttgga acgcggattt ggcagggcga aggtgacatc gttgaagagt 9420
atctttcccg cgcgaggcat aaagttgcgt gtgatgcgga agggtcccgg cacctcggaa 9480
cggttgttaa ttacctgggc ggcgagcacg atctcgtcaa agccgttgat gttgtggccc 9540
acaatgtaaa gttccaagaa gcgcgggatg cccttgatgg aaggcaattt tttaagttcc 9600
tcgtaggtga gctcttcagg ggagctgagc ccgtgctctg aaagggccca gtctgcaaga 9660
tgagggttgg aagcgacgaa tgagctccac aggtcacggg ccattagcat ttgcaggtgg 9720
tcgcgaaagg tcctaaactg gcgacctatg gccatttttt ctggggtgat gcagtagaag 9780
gtaagcgggt cttgttccca gcggtcccat ccaaggttcg cggctaggtc tcgcgcggca 9840
gtcactagag gctcatctcc gccgaacttc atgaccagca tgaagggcac gagctgcttc 9900
ccaaaggccc ccatccaagt ataggtctct acatcgtagg tgacaaagag acgctcggtg 9960
cgaggatgcg agccgatcgg gaagaactgg atctcccgcc accaattgga ggagtggcta 10020
ttgatgtggt gaaagtagaa gtccctgcga cgggccgaac actcgtgctg gcttttgtaa 10080
aaacgtgcgc agtactggca gcggtgcacg ggctgtacat cctgcacgag gttgacctga 10140
cgaccgcgca caaggaagca gagtgggaat ttgagcccct cgcctggcgg gtttggctgg 10200
tggtcttcta cttcggctgc ttgtccttga ccgtctggct gctcgagggg agttacggtg 10260
gatcggacca ccacgccgcg cgagcccaaa gtccagatgt ccgcgcgcgg cggtcggagc 10320
ttgatgacaa catcgcgcag atgggagctg tccatggtct ggagctcccg cggcgtcagg 10380
tcaggcggga gctcctgcag gtttacctcg catagacggg tcagggcgcg ggctagatcc 10440
aggtgatacc taatttccag gggctggttg gtggcggcgt cgatggcttg caagaggccg 10500
catccccgcg gcgcgactac ggtaccgcgc ggcgggcggt gggccgcggg ggtgtccttg 10560
gatgatgcat ctaaaagcgg tgacgcgggc gagcccccgg aggtaggggg ggctccggac 10620
ccgccgggag agggggcagg ggcacgtcgg cgccgcgcgc gggcaggagc tggtgctgcg 10680
cgcgtaggtt gctggcgaac gcgacgacgc ggcggttgat ctcctgaatc tggcgcctct 10740
gcgtgaagac gacgggcccg gtgagcttga gcctgaaaga gagttcgaca gaatcaattt 10800
cggtgtcgtt gacggcggcc tggcgcaaaa tctcctgcac gtctcctgag ttgtcttgat 10860
aggcgatctc ggccatgaac tgctcgatct cttcctcctg gagatctccg cgtccggctc 10920
gctccacggt ggcggcgagg tcgttggaaa tgcgggccat gagctgcgag aaggcgttga 10980
ggcctccctc gttccagacg cggctgtaga ccacgccccc ttcggcatcg cgggcgcgca 11040
tgaccacctg cgcgagattg agctccacgt gccgggcgaa gacggcgtag tttcgcaggc 11100
gctgaaagag gtagttgagg gtggtggcgg tgtgttctgc cacgaagaag tacataaccc 11160
agcgtcgcaa cgtggattcg ttgatatccc ccaaggcctc aaggcgctcc atggcctcgt 11220
agaagtccac ggcgaagttg aaaaactggg agttgcgcgc cgacacggtt aactcctcct 11280
ccagaagacg gatgagctcg gcgacagtgt cgcgcacctc gcgctcaaag gctacagggg 11340
cctcttcttc ttcttcaatc tcctcttcca taagggcctc cccttcttct tcttctggcg 11400
gcggtggggg aggggggaca cggcggcgac gacggcgcac cgggaggcgg tcgacaaagc 11460
gctcgatcat ctccccgcgg cgacggcgca tggtctcggt gacggcgcgg ccgttctcgc 11520
gggggcgcag ttggaagacg ccgcccgtca tgtcccggtt atgggttggc ggggggctgc 11580
catgcggcag ggatacggcg ctaacgatgc atctcaacaa ttgttgtgta ggtactccgc 11640
cgccgaggga cctgagcgag tccgcatcga ccggatcgga aaacctctcg agaaaggcgt 11700
ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc gggcggcagc gggcggcggt 11760
cggggttgtt tctggcggag gtgctgctga tgatgtaatt aaagtaggcg gtcttgagac 11820
ggcggatggt cgacagaagc accatgtcct tgggtccggc ctgctgaatg cgcaggcggt 11880
cggccatgcc ccaggcttcg ttttgacatc ggcgcaggtc tttgtagtag tcttgcatga 11940
gcctttctac cggcacttct tcttctcctt cctcttgtcc tgcatctctt gcatctatcg 12000
ctgcggcggc ggcggagttt ggccgtaggt ggcgccctct tcctcccatg cgtgtgaccc 12060
cgaagcccct catcggctga agcagggcta ggtcggcgac aacgcgctcg gctaatatgg 12120
cctgctgcac ctgcgtgagg gtagactgga agtcatccat gtccacaaag cggtggtatg 12180
cgcccgtgtt gatggtgtaa gtgcagttgg ccataacgga ccagttaacg gtctggtgac 12240
ccggctgcga gagctcggtg tacctgagac gcgagtaagc cctcgagtca aatacgtagt 12300
cgttgcaagt ccgcaccagg tactggtatc ccaccaaaaa gtgcggcggc ggctggcggt 12360
agaggggcca gcgtagggtg gccggggctc cgggggcgag atcttccaac ataaggcgat 12420
gatatccgta gatgtacctg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg 12480
gaaagtcgcg gacgcggttc cagatgttgc gcagcggcaa aaagtgctcc atggtcggga 12540
cgctctggcc ggtcaggcgc gcgcaatcgt tgacgctcta gaccgtgcaa aaggagagcc 12600
tgtaagcggg cactcttccg tggtctggtg gataaattcg caagggtatc atggcggacg 12660
accggggttc gagccccgta tccggccgtc cgccgtgatc catgcggtta ccgcccgcgt 12720
gtcgaaccca ggtgtgcgac gtcagacaac gggggagtgc tccttttggc ttccttccag 12780
gcgcggcggc tgctgcgcta gcttttttgg ccactggccg cgcgcagcgt aagcggttag 12840
gctggaaagc gaaagcatta agtggctcgc tccctgtagc cggagggtta ttttccaagg 12900
gttgagtcgc gggacccccg gttcgagtct cggaccggcc ggactgcggc gaacgggggt 12960
ttgcctcccc gtcatgcaag accccgcttg caaattcctc cggaaacagg gacgagcccc 13020
ttttttgctt ttcccagatg catccggtgc tgcggcagat gcgcccccct cctcagcagc 13080
ggcaagagca agagcagcgg cagacatgca gggcaccctc ccctcctcct accgcgtcag 13140
gaggggcgac atccgcggtt gacgcggcag cagatggtga ttacgaaccc ccgcggcgcc 13200
gggcccggca ctacctggac ttggaggagg gcgagggcct ggcgcggcta ggagcgccct 13260
ctcctgagcg gtacccaagg gtgcagctga agcgtgatac gcgtgaggcg tacgtgccgc 13320
ggcagaacct gtttcgcgac cgcgagggag aggagcccga ggagatgcgg gatcgaaagt 13380
tccacgcagg gcgcgagctg cggcatggcc tgaatcgcga gcggttgctg cgcgaggagg 13440
actttgagcc cgacgcgcga accgggatta gtcccgcgcg cgcacacgtg gcggccgccg 13500
acctggtaac cgcatacgag cagacggtga accaggagat taactttcaa aaaagcttta 13560
acaaccacgt gcgtacgctt gtggcgcgcg aggaggtggc tataggactg atgcatctgt 13620
gggactttgt aagcgcgctg gagcaaaacc caaatagcaa gccgctcatg gcgcagctgt 13680
tccttatagt gcagcacagc agggacaacg aggcattcag ggatgcgctg ctaaacatag 13740
tagagcccga gggccgctgg ctgctcgatt tgataaacat cctgcagagc atagtggtgc 13800
aggagcgcag cttgagcctg gctgacaagg tggccgccat caactattcc atgcttagcc 13860
tgggcaagtt ttacgcccgc aagatatacc atacccctta cgttcccata gacaaggagg 13920
taaagatcga ggggttctac atgcgcatgg cgctgaaggt gcttaccttg agcgacgacc 13980
tgggcgttta tcgcaacgag cgcatccaca aggccgtgag cgtgagccgg cggcgcgagc 14040
tcagcgaccg cgagctgatg cacagcctgc aaagggccct ggctggcacg ggcagcggcg 14100
atagagaggc cgagtcctac tttgacgcgg gcgctgacct gcgctgggcc ccaagccgac 14160
gcgccctgga ggcagctggg gccggacctg ggctggcggt ggcacccgcg cgcgctggca 14220
acgtcggcgg cgtggaggaa tatgacgagg acgatgagta cgagccagag gacggcgagt 14280
actaagcggt gatgtttctg atcagatgat gcaagacgca acggacccgg cggtgcgggc 14340
ggcgctgcag agccagccgt ccggccttaa ctccacggac gactggcgcc aggtcatgga 14400
ccgcatcatg tcgctgactg cgcgcaatcc tgacgcgttc cggcagcagc cgcaggccaa 14460
ccggctctcc gcaattctgg aagcggtggt cccggcgcgc gcaaacccca cgcacgagaa 14520
ggtgctggcg atcgtaaacg cgctggccga aaacagggcc atccggcccg acgaggccgg 14580
cctggtctac gacgcgctgc ttcagcgcgt ggctcgttac aacagcggca acgtgcagac 14640
caacctggac cggctggtgg gggatgtgcg cgaggccgtg gcgcagcgtg agcgcgcgca 14700
gcagcagggc aacctgggct ccatggttgc actaaacgcc ttcctgagta cacagcccgc 14760
caacgtgccg cggggacagg aggactacac caactttgtg agcgcactgc ggctaatggt 14820
gactgagaca ccgcaaagtg aggtgtacca gtctgggcca gactattttt tccagaccag 14880
tagacaaggc ctgcagaccg taaacctgag ccaggctttc aaaaacttgc aggggctgtg 14940
gggggtgcgg gctcccacag gcgaccgcgc gaccgtgtct agcttgctga cgcccaactc 15000
gcgcctgttg ctgctgctaa tagcgccctt cacggacagt ggcagcgtgt cccgggacac 15060
atacctaggt cacttgctga cactgtaccg cgaggccata ggtcaggcgc atgtggacga 15120
gcatactttc caggagatta caagtgtcag ccgcgcgctg gggcaggagg acacgggcag 15180
cctggaggca accctaaact acctgctgac caaccggcgg cagaagatcc cctcgttgca 15240
cagtttaaac agcgaggagg agcgcatttt gcgctacgtg cagcagagcg tgagccttaa 15300
cctgatgcgc gacggggtaa cgcccagcgt ggcgctggac atgaccgcgc gcaacatgga 15360
accgggcatg tatgcctcaa accggccgtt tatcaaccgc ctaatggact acttgcatcg 15420
cgcggccgcc gtgaaccccg agtatttcac caatgccatc ttgaacccgc actggctacc 15480
gccccctggt ttctacaccg ggggattcga ggtgcccgag ggtaacgatg gattcctctg 15540
ggacgacata gacgacagcg tgttttcccc gcaaccgcag accctgctag agttgcaaca 15600
gcgcgagcag gcagaggcgg cgctgcgaaa ggaaagcttc cgcaggccaa gcagcttgtc 15660
cgatctaggc gctgcggccc cgcggtcaga tgctagtagc ccatttccaa gcttgatagg 15720
gtctcttacc agcactcgca ccacccgccc gcgcctgctg ggcgaggagg agtacctaaa 15780
caactcgctg ctgcagccgc agcgcgaaaa aaacctgcct ccggcatttc ccaacaacgg 15840
gatagagagc ctagtggaca agatgagtag atggaagacg tacgcgcagg agcacaggga 15900
cgtgccaggc ccgcgcccgc ccacccgtcg tcaaaggcac gaccgtcagc ggggtctggt 15960
gtgggaggac gatgactcgg cagacgacag cagcgtcctg gatttgggag ggagtggcaa 16020
cccgtttgcg caccttcgcc ccaggctggg gagaatgttt taaaaaaaaa aaagcatgat 16080
gcaaaataaa aaactcacca aggccatggc accgagcgtt ggttttcttg tattcccctt 16140
agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc cctcctacga gagtgtggtg 16200
agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg atgctcccct ggacccgccg 16260
tttgtgcctc cgcggtacct gcggcctacc ggggggagaa acagcatccg ttactctgag 16320
ttggcacccc tattcgacac cacccgtgtg tacctggtgg acaacaagtc aacggatgtg 16380
gcatccctga actaccagaa cgaccacagc aactttctga ccacggtcat tcaaaacaat 16440
gactacagcc cgggggaggc aagcacacag accatcaatc ttgacgaccg gtcgcactgg 16500
ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa atgtgaacga gttcatgttt 16560
accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc ctactaagga caatcaggtg 16620
gagctgaaat acgagtgggt ggagttcacg ctgcccgagg gcaactactc cgagaccatg 16680
accatagacc ttatgaacaa cgcgatcgtg gagcactact tgaaagtggg cagacagaac 16740
ggggttctgg aaagcgacat cggggtaaag tttgacaccc gcaacttcag actggggttt 16800
gaccccgtca ctggtcttgt catgcctggg gtatatacaa acgaagcctt ccatccagac 16860
atcattttgc tgccaggatg cggggtggac ttcacccaca gccgcctgag caacttgttg 16920
ggcatccgca agcggcaacc cttccaggag ggctttagga tcacctacga tgatctggag 16980
ggtggtaaca ttcccgcact gttggatgtg gacgcctacc aggcgagctt gaaagatgac 17040
accgaacagg gcgggggtgg cgcaggcggc agcaacagca gtggcagcgg cgcggaagag 17100
aactccaacg cggcagccgc ggcaatgcag ccggtggagg acatgaacga tcatgccatt 17160
cgcggcgaca cctttgccac acgggctgag gagaagcgcg ctgaggccga agcagcggcc 17220
gaagctgccg cccccgctgc gcaacccgag gtcgagaagc ctcagaagaa accggtgatc 17280
aaacccctga cagaggacag caagaaacgc agttacaacc taataagcaa tgacagcacc 17340
ttcacccagt accgcagctg gtaccttgca tacaactacg gcgaccctca gaccggaatc 17400
cgctcatgga ccctgctttg cactcctgac gtaacctgcg gctcggagca ggtctactgg 17460
tcgttgccag acatgatgca agaccccgtg accttccgct ccacgcgcca gatcagcaac 17520
tttccggtgg tgggcgccga gctgttgccc gtgcactcca agagcttcta caacgaccag 17580
gccgtctact cccaactcat ccgccagttt acctctctga cccacgtgtt caatcgcttt 17640
cccgagaacc agattttggc gcgcccgcca gcccccacca tcaccaccgt cagtgaaaac 17700
gttcctgctc tcacagatca cgggacgcta ccgctgcgca acagcatcgg aggagtccag 17760
cgagtgacca ttactgacgc cagacgccgc acctgcccct acgtttacaa ggccctgggc 17820
atagtctcgc cgcgcgtcct atcgagccgc actttttgag caagcatgtc catccttata 17880
tcgcccagca ataacacagg ctggggcctg cgcttcccaa gcaagatgtt tggcggggcc 17940
aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc actaccgcgc gccctggggc 18000
gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg acgccatcga cgcggtggtg 18060
gaggaggcgc gcaactacac gcccacgccg ccaccagtgt ccacagtgga cgcggccatt 18120
cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga agagacggcg gaggcgcgta 18180
gcacgtcgcc accgccgccg acccggcact gccgcccaac gcgcggcggc ggccctgctt 18240
aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg ccgctcgaag gctggccgcg 18300
ggtattgtca ctgtgccccc caggtccagg cgacgagcgg ccgccgcagc agccgcggcc 18360
attagtgcta tgactcaggg tcgcaggggc aacgtgtatt gggtgcgcga ctcggttagc 18420
ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact agattgcaag aaaaaactac 18480
ttagactcgt actgttgtat gtatccagcg gcggcggcgc gcaacgaagc tatgtccaag 18540
cgcaaaatca aagaagagat gctccaggtc atcgcgccgg agatctatgg ccccccgaag 18600
aaggaagagc aggattacaa gccccgaaag ctaaagcggg tcaaaaagaa aaagaaagat 18660
gatgatgatg aacttgacga cgaggtggaa ctgctgcacg ctaccgcgcc caggcgacgg 18720
gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac ccggcaccac cgtagtcttt 18780
acgcccggtg agcgctccac ccgcacctac aagcgcgtgt atgatgaggt gtacggcgac 18840
gaggacctgc ttgagcaggc caacgagcgc ctcggggagt ttgcctacgg aaagcggcat 18900
aaggacatgc tggcgttgcc gctggacgag ggcaacccaa cacctagcct aaagcccgta 18960
acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag aaaagcgcgg cctaaagcgc 19020
gagtctggtg acttggcacc caccgtgcag ctgatggtac ccaagcgcca gcgactggaa 19080
gatgtcttgg aaaaaatgac cgtggaacct gggctggagc ccgaggtccg cgtgcggcca 19140
atcaagcagg tggcgccggg actgggcgtg cagaccgtgg acgttcagat acccactacc 19200
agtagcacca gtattgccac cgccacagag ggcatggaga cacaaacgtc cccggttgcc 19260
tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg ccgcgtccaa gacctctacg 19320
gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc cccggcgccc gcgcggttcg 19380
aggaagtacg gcgccgccag cgcgctactg cccgaatatg ccctacatcc ttccattgcg 19440
cctacccccg gctatcgtgg ctacacctac cgccccagaa gacgagcaac tacccgacgc 19500
cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc agcccgtgct ggccccgatt 19560
tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg tgctgccaac agcgcgctac 19620
caccccagca tcgtttaaaa gccggtcttt gtggttcttg cagatatggc cctcacctgc 19680
cgcctccgtt tcccggtgcc gggattccga ggaagaatgc accgtaggag gggcatggcc 19740
ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc ggcggcggcg cgcgtcgcac 19800
cgtcgcatgc gcggcggtat cctgcccctc cttattccac tgatcgccgc ggcgattggc 19860
gccgtgcccg gaattgcatc cgtggccttg caggcgcaga gacactgatt aaaaacaagt 19920
tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac gctcgcttgg tcctgtaact 19980
attttgtaga atggaagaca tcaactttgc gtctctggcc ccgcgacacg gctcgcgccc 20040
gttcatggga aactggcaag atatcggcac cagcaatatg agcggtggcg ccttcagctg 20100
gggctcgctg tggagcggca ttaaaaattt cggttccacc gttaagaact atggcagcaa 20160
ggcctggaac agcagcacag gccagatgct gagggataag ttgaaagagc aaaatttcca 20220
acaaaaggtg gtagatggcc tggcctctgg cattagcggg gtggtggacc tggccaacca 20280
ggcagtgcaa aataagatta acagtaagct tgatccccgc cctcccgtag aggagcctcc 20340
accggccgtg gagacagtgt ctccagaggg gcgtggcgaa aagcgtccgc gccccgacag 20400
ggaagaaact ctggtgacgc aaatagacga gcctccctcg tacgaggagg cactaaagca 20460
aggcctgccc accacccgtc ccatcgcgcc catggctacc ggagtgctgg gccagcacac 20520
acccgtaacg ctggacctgc ctccccccgc cgacacccag cagaaacctg tgctgccagg 20580
cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc ctgcgccgcg ccgccagcgg 20640
tccgcgatcg ttgcggcccg tagccagtgg caactggcaa agcacactga acagcatcgt 20700
gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc tgaatagcta acgtgtcgta 20760
tgtgtgtcat gtatgcgtcc atgtcgccgc cagaggagct gctgagccgc cgcgcgcccg 20820
ctttccaaga tggctacccc ttcgatgatg ccgcagtggt cttacatgca catctcgggc 20880
caggacgcct cggagtacct gagccccggg ctggtgcagt ttgcccgcgc caccgagacg 20940
tacttcagcc tgaataacaa gtttagaaac cccacggtgg cgcctacgca cgacgtgacc 21000
acagaccggt cccagcgttt gacgctgcgg ttcatccctg tggaccgtga ggatactgcg 21060
tactcgtaca aggcgcggtt caccctagct gtgggtgata accgtgtgct ggacatggct 21120
tccacgtact ttgacatccg cggcgtgctg gacaggggcc ctacttttaa gccctactct 21180
ggcactgcct acaacgccct ggctcccaag ggtgccccaa atccttgcga atgggatgaa 21240
gctgctactg ctcttgaaat aaacctagaa gaagaggacg atgacaacga agacgaagta 21300
gacgagcaag ctgagcagca aaaaactcac gtatttgggc aggcgcctta ttctggtata 21360
aatattacaa aggagggtat tcaaataggt gtcgaaggtc aaacacctaa atatgccgat 21420
aaaacatttc aacctgaacc tcaaatagga gaatctcagt ggtacgaaac tgaaattaat 21480
catgcagctg ggagagtcct taaaaagact accccaatga aaccatgtta cggttcatat 21540
gcaaaaccca caaatgaaaa tggagggcaa ggcattcttg taaagcaaca aaatggaaag 21600
ctagaaagtc aagtggaaat gcaatttttc tcaactactg aggcgaccgc aggcaatggt 21660
gataacttga ctcctaaagt ggtattgtac agtgaagatg tagatataga aaccccagac 21720
actcatattt cttacatgcc cactattaag gaaggtaact cacgagaact aatgggccaa 21780
caatctatgc ccaacaggcc taattacatt gcttttaggg acaattttat tggtctaatg 21840
tattacaaca gcacgggtaa tatgggtgtt ctggcgggcc aagcatcgca gttgaatgct 21900
gttgtagatt tgcaagacag aaacacagag ctttcatacc agcttttgct tgattccatt 21960
ggtgatagaa ccaggtactt ttctatgtgg aatcaggctg ttgacagcta tgatccagat 22020
gttagaatta ttgaaaatca tggaactgaa gatgaacttc caaattactg ctttccactg 22080
ggaggtgtga ttaatacaga gactcttacc aaggtaaaac ctaaaacagg tcaggaaaat 22140
ggatgggaaa aagatgctac agaattttca gataaaaatg aaataagagt tggaaataat 22200
tttgccatgg aaatcaatct aaatgccaac ctgtggagaa atttcctgta ctccaacata 22260
gcgctgtatt tgcccgacaa gctaaagtac agtccttcca acgtaaaaat ttctgataac 22320
ccaaacacct acgactacat gaacaagcga gtggtggctc ccgggttagt ggactgctac 22380
attaaccttg gagcacgctg gtcccttgac tatatggaca acgtcaaccc atttaaccac 22440
caccgcaatg ctggcctgcg ctaccgctca atgttgctgg gcaatggtcg ctatgtgccc 22500
ttccacatcc aggtgcctca gaagttcttt gccattaaaa acctccttct cctgccgggc 22560
tcatacacct acgagtggaa cttcaggaag gatgttaaca tggttctgca gagctcccta 22620
ggaaatgacc taagggttga cggagccagc attaagtttg atagcatttg cctttacgcc 22680
accttcttcc ccatggccca caacaccgcc tccacgcttg aggccatgct tagaaacgac 22740
accaacgacc agtcctttaa cgactatctc tccgccgcca acatgctcta ccctataccc 22800
gccaacgcta ccaacgtgcc catatccatc ccctcccgca actgggcggc tttccgcggc 22860
tgggccttca cgcgccttaa gactaaggaa accccatcac tgggctcggg ctacgaccct 22920
tattacacct actctggctc tataccctac ctagatggaa ccttttacct caaccacacc 22980
tttaagaagg tggccattac ctttgactct tctgtcagct ggcctggcaa tgaccgcctg 23040
cttaccccca acgagtttga aattaagcgc tcagttgacg gggagggtta caacgttgcc 23100
cagtgtaaca tgaccaaaga ctggttcctg gtacaaatgc tagctaacta caacattggc 23160
taccagggct tctatatccc agagagctac aaggaccgca tgtactcctt ctttagaaac 23220
ttccagccca tgagccgtca ggtggtggat gatactaaat acaaggacta ccaacaggtg 23280
ggcatcctac accaacacaa caactctgga tttgttggct accttgcccc caccatgcgc 23340
gaaggacagg cctaccctgc taacttcccc tatccgctta taggcaagac cgcagttgac 23400
agcattaccc agaaaaagtt tctttgcgat cgcacccttt ggcgcatccc attctccagt 23460
aactttatgt ccatgggcgc actcacagac ctgggccaaa accttctcta cgccaactcc 23520
gcccacgcgc tagacatgac ttttgaggtg gatcccatgg acgagcccac ccttctttat 23580
gttttgtttg aagtctttga cgtggtccgt gtgcaccggc cgcaccgcgg cgtcatcgaa 23640
accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca caacataaag aagcaagcaa 23700
catcaacaac agctgccgcc atgggctcca gtgagcagga actgaaagcc attgtcaaag 23760
atcttggttg tgggccatat tttttgggca cctatgacaa gcgctttcca ggctttgttt 23820
ctccacacaa gctcgcctgc gccatagtca atacggccgg tcgcgagact gggggcgtac 23880
actggatggc ctttgcctgg aacccgcact caaaaacatg ctacctcttt gagccctttg 23940
gcttttctga ccagcgactc aagcaggttt accagtttga gtacgagtca ctcctgcgcc 24000
gtagcgccat tgcttcttcc cccgaccgct gtataacgct ggaaaagtcc acccaaagcg 24060
tacaggggcc caactcggcc gcctgtggac tattctgctg catgtttctc cacgcctttg 24120
ccaactggcc ccaaactccc atggatcaca accccaccat gaaccttatt accggggtac 24180
ccaactccat gctcaacagt ccccaggtac agcccaccct gcgtcgcaac caggaacagc 24240
tctacagctt cctggagcgc cactcgccct acttccgcag ccacagtgcg cagattagga 24300
gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata atgtactaga gacactttca 24360
ataaaggcaa atgcttttat ttgtacactc tcgggtgatt atttaccccc acccttgccg 24420
tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc gctatgcgcc actggcaggg 24480
acacgttgcg atactggtgt ttagtgctcc acttaaactc aggcacaacc atccgcggca 24540
gctcggtgaa gttttcactc cacaggctgc gcaccatcac caacgcgttt agcaggtcgg 24600
gcgccgatat cttgaagtcg cagttggggc ctccgccctg cgcgcgcgag ttgcgataca 24660
cagggttgca gcactggaac actatcagcg ccgggtggtg cacgctggcc agcacgctct 24720
tgtcggagat cagatccgcg tccaggtcct ccgcgttgct cagggcgaac ggagtcaact 24780
ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt tgagttgcac tcgcaccgta 24840
gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg atacagcgcc tgcataaaag 24900
ccttgatctg cttaaaagcc acctgagcct ttgcgccttc agagaagaac atgccgcaag 24960
acttgccgga aaactgattg gccggacagg ccgcgtcgtg cacgcagcac cttgcgtcgg 25020
tgttggagat ctgcaccaca tttcggcccc accggttctt cacgatcttg gccttgctag 25080
actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac atccatttca atcacgtgct 25140
ccttatttat cataatgctt ccgtgtagac acttaagctc gccttcgatc tcagcgcagc 25200
ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt gtaggtcacc tctgcaaacg 25260
actgcaggta cgcctgcagg aatcgcccca tcatcgtcac aaaggtcttg ttgctggtga 25320
aggtcagctg caacccgcgg tgctcctcgt tcagccaggt cttgcatacg gccgccagag 25380
cttccacttg gtcaggcagt agtttgaagt tcgcctttag atcgttatcc acgtggtact 25440
tgtccatcag cgcgcgcgca gcctccatgc ccttctccca cgcagacacg atcggcacac 25500
tcagcgggtt catcaccgta atttcacttt ccgcttcgct gggctcttcc tcttcctctt 25560
gcgtccgcat accacgcgcc actgggtcgt cttcattcag ccgccgcact gtgcgcttac 25620
ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa acccaccatt tgtagcgcca 25680
catcttctct ttcttcctcg ctgtccacga ttacctctgg tgatggcggg cgctcgggct 25740
tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc caaatccgcc gccgaggtcg 25800
atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg tgatgagtct tcctcgtcct 25860
cggactcgat acgccgcctc atccgctttt ttgggggcgc ccggggaggc ggcggcgacg 25920
gggacgggga cgacacgtcc tccatggttg ggggacgtcg cgccgcaccg cgtccgcgct 25980
cgggggtggt ttcgcgctgc tcctcttccc gactggccat ttccttctcc tataggcaga 26040
aaaagatcat ggagtcagtc gagaagaagg acagcctaac cgccccctct gagttcgcca 26100
ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt ccccgtcgag gcacccccgc 26160
ttgaggagga ggaagtgatt atcgagcagg acccaggttt tgtaagcgaa gacgacgagg 26220
accgctcagt accaacagag gataaaaagc aagaccagga caacgcagag gcaaacgagg 26280
aacaagtcgg gcggggggac gaaaggcatg gcgactacct agatgtggga gacgacgtgc 26340
tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga cgcgttgcaa gagcgcagcg 26400
atgtgcccct cgccatagcg gatgtcagcc ttgcctacga acgccaccta ttctcaccgc 26460
gcgtaccccc caaacgccaa gaaaacggca catgcgagcc caacccgcgc ctcaacttct 26520
accccgtatt tgccgtgcca gaggtgcttg ccacctatca catctttttc caaaactgca 26580
agatacccct atcctgccgt gccaaccgca gccgagcgga caagcagctg gccttgcggc 26640
agggcgctgt catacctgat atcgcctcgc tcaacgaagt gccaaaaatc tttgagggtc 26700
ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca ggaaaacagc gaaaatgaaa 26760
gtcactctgg agtgttggtg gaactcgagg gtgacaacgc gcgcctagcc gtactaaaac 26820
gcagcatcga ggtcacccac tttgcctacc cggcacttaa cctacccccc aaggtcatga 26880
gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc cctggagagg gatgcaaatt 26940
tgcaagaaca aacagaggag ggcctacccg cagttggcga cgagcagcta gcgcgctggc 27000
ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa actaatgatg gccgcagtgc 27060
tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc tgacccggag atgcagcgca 27120
agctagagga aacattgcac tacacctttc gacagggcta cgtacgccag gcctgcaaga 27180
tctccaacgt ggagctctgc aacctggtct cctaccttgg aattttgcac gaaaaccgcc 27240
ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc gcgccgcgac tacgtccgcg 27300
actgcgttta cttatttcta tgctacacct ggcagacggc catgggcgtt tggcagcagt 27360
gcttggagga gtgcaacctc aaggagctgc agaaactgct aaagcaaaac ttgaaggacc 27420
tatggacggc cttcaacgag cgctccgtgg ccgcgcacct ggcggacatc attttccccg 27480
aacgcctgct taaaaccctg caacagggtc tgccagactt caccagtcaa agcatgttgc 27540
agaactttag gaactttatc ctagagcgct caggaatctt gcccgccacc tgctgtgcac 27600
ttcctagcga ctttgtgccc attaagtacc gcgaatgccc tccgccgctt tggggccact 27660
gctaccttct gcagctagcc aactaccttg cctaccactc tgacataatg gaagacgtga 27720
gcggtgacgg tctactggag tgtcactgtc gctgcaacct atgcaccccg caccgctccc 27780
tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat cggtaccttt gagctgcagg 27840
gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa actcactccg gggctgtgga 27900
cgtcggctta ccttcgcaaa tttgtacctg aggactacca cgcccacgag attaggttct 27960
acgaagacca atcccgcccg ccaaatgcgg agcttaccgc ctgcgtcatt acccagggcc 28020
acattcttgg ccaattgcaa gccatcaaca aagcccgcca agagtttctg ctacgaaagg 28080
gacggggggt ttacttggac ccccagtccg gcgaggagct caacccaatc cccccgccgc 28140
cgcagcccta tcagcagcag ccgcgggccc ttgcttccca ggatggcacc caaaaagaag 28200
ctgcagctgc cgccgccacc cacggacgag gaggaatact gggacagtca ggcagaggag 28260
gttttggacg aggaggagga ggacatgatg gaagactggg agagcctaga cgaggaagct 28320
tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct cggtcgcatt cccctcgccg 28380
gcgccccaga aatcggcaac cggttccagc atggctacaa cctccgctcc tcaggcgccg 28440
ccggcactgc ccgttcgccg acccaaccgt agatgggaca ccactggaac cagggccggt 28500
aagtccaagc agccgccgcc gttagcccaa gagcaacaac agcgccaagg ctaccgctca 28560
tggcgcgggc acaagaacgc catagttgct tgcttgcaag actgtggggg caacatctcc 28620
ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct tcccccgtaa catcctgcat 28680
tactaccgtc atctctacag cccatactgc accggcggca gcggcagcgg cagcaacagc 28740
agcggccaca cagaagcaaa ggcgaccgga tagcaagact ctgacaaagc ccaagaaatc 28800
cacagcggcg gcagcagcag gaggaggagc gctgcgtctg gcgcccaacg aacccgtatc 28860
gacccgcgag cttagaaaca ggatttttcc cactctgtat gctatatttc aacagagcag 28920
gggccaagaa caagagctga aaataaaaaa caggtctctg cgatccctca cccgcagctg 28980
cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg gaagacgcgg aggctctctt 29040
cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc gccctttctc aaatttaagc 29100
gcgaaaacta cgtcatctcc agcggccaca cccggcgcca gcacctgtcg tcagcgccat 29160
tatgagcaag gaaattccca cgccctacat gtggagttac cagccacaaa tgggacttgc 29220
ggctggagct gcccaagact actcaacccg aataaactac atgagcgcgg gaccccacat 29280
gatatcccgg gtcaacggaa tccgcgccca ccgaaaccga attctcttgg aacaggcggc 29340
tattaccacc acacctcgta ataaccttaa tccccgtagt tggcccgctg ccctggtgta 29400
ccaggaaagt cccgctccca ccactgtggt acttcccaga gacgcccagg ccgaagttca 29460
gatgactaac tcaggggcgc agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg 29520
gcagggtata actcacctga caatcagagg gcgaggtatt cagctcaacg acgagtcggt 29580
gagctcctcg cttggtctcc gtccggacgg gacatttcag atcggcggcg ccggccgtcc 29640
ttcattcacg cctcgtcagg caatcctaac tctgcagacc tcgtcctctg agccgcgctc 29700
tggaggcatt ggaactctgc aatttattga ggagtttgtg ccatcggtct actttaaccc 29760
cttctcggga cctcccggcc actatccgga tcaatttatt cctaactttg acgcggtaaa 29820
ggactcggcg gacggctacg actgaatgtt aagtggagag gcagagcaac tgcgcctgaa 29880
acacctggtc cactgtcgcc gccacaagtg ctttgcccgc gactccggtg agttttgcta 29940
ctttgaattg cccgaggatc atatcgaggg cccggcgcac ggcgtccggc ttaccgccca 30000
gggagagctt gcccgtagcc tgattcggga gtttacccag cgccccctgc tagttgagcg 30060
ggacagggga ccctgtgttc tcactgtgat ttgcaactgt cctaaccttg gattacatca 30120
agatctttgt tgccatctct gtgctgagta taataaatac agaaattaaa atatactggg 30180
gctcctatcg ccatcctgta aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa 30240
ccttacctgg tacttttaac atctctccct ctgtgattta caacagtttc aacccagacg 30300
gagtgagtct acgagagaac ctctccgagc tcagctactc catcagaaaa aacaccaccc 30360
tccttacctg ccgggaacgt acgagtgcgt caccggccgc tgcaccacac ctaccgcctg 30420
accgtaaacc agactttttc cggacagacc tcaataactc tgtttaccag aacaggaggt 30480
gagcttagaa aacccttagg gtattaggcc aaaggcgcag ctactgtggg gtttatgaac 30540
aattcaagca actctacggg ctattctaat tcaggtttct ctagaaatgg acggaattat 30600
tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc gcatgaatca 30660
agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt gtctggtaaa 30720
gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct acaagttgcc 30780
aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca taactcagca 30840
ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg atctctgcac 30900
ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat aaaaaaaaat 30960
aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta ttcagcagca 31020
cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca aactttctcc 31080
acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc actatcttca 31140
tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc gtgtatccat 31200
atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt gtatccccca 31260
atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa cctctagtta 31320
cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac gaggccggca 31380
accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc aagtcaaaca 31440
taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact gtggctgccg 31500
ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc ccgctaaccg 31560
tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca gaaggaaagc 31620
tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt actatcactg 31680
cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa gagcccattt 31740
atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta acagacgacc 31800
taaacacttt gaccgtagca actggtccag gtgtgactat taataatact tccttgcaaa 31860
ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt aatgtagcag 31920
gaggactaag gattgattct caaaacagac gccttatact tgatgttagt tatccgtttg 31980
atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata aactcagccc 32040
acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca aacaattcca 32100
aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct acagccatag 32160
ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac acaaatcccc 32220
tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg gttcctaaac 32280
taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac aaaaataatg 32340
ataagctaac tttgtggacc acaccagctc catctcctaa ctgtagacta aatgcagaga 32400
aagatgctaa actcactttg gtcttaacaa aatgtggcag tcaaatactt gctacagttt 32460
cagttttggc tgttaaaggc agtttggctc caatatctgg aacagttcaa agtgctcatc 32520
ttattataag atttgacgaa aatggagtgc tactaaacaa ttccttcctg gacccagaat 32580
attggaactt tagaaatgga gatcttactg aaggcacagc ctatacaaac gctgttggat 32640
ttatgcctaa cctatcagct tatccaaaat ctcacggtaa aactgccaaa agtaacattg 32700
tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt aacactaacc attacactaa 32760
acggtacaca ggaaacagga gacacaactc caagtgcata ctctatgtca ttttcatggg 32820
actggtctgg ccacaactac attaatgaaa tatttgccac atcctcttac actttttcat 32880
acattgccca agaataaaga atcgtttgtg ttatgtttca acgtgtttat ttttcaattg 32940
cagaaaattt cgaatcattt ttcattcagt agtatagccc caccaccaca tagcttatac 33000
agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc acctccctcc 33060
caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat catatcatgg 33120
gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc caaacgctca 33180
tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct gtccagctgc 33240
tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg agaagtccac 33300
gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg ctgcagcagc 33360
gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat ggcagtggtc 33420
tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg ggcacagcag 33480
cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac aatattgttc 33540
aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac agaacccacg 33600
tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa cacgctggac 33660
ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca tataaacctc 33720
tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac ctgcccgccg 33780
gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca ggactcgtaa 33840
ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca cacgtgcata 33900
cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg aacaacccat 33960
tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact cacgttgtgc 34020
attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt agcgcgggtt 34080
tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga caaccgagat 34140
cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt tcctgaagca 34200
aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct tagatcgctc 34260
tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc tggcttcggg 34320
ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg cagaataagc 34380
cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag cgggaagagc 34440
tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca aaatgaagat 34500
ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc aaagaacaga 34560
taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc ctcacgtcca 34620
agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt ccagcacctt 34680
caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta agcaaatccc 34740
gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc ttcagcctca 34800
agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa gattcaaaag 34860
cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca gctgaacata 34920
atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacct tgacaaaaga 34980
acccacactg attatgacac gcatactcgg agctatgcta accagcgtag ccccgatgta 35040
agctttgttg catgggcggc gatataaaat gcaaggtgct gctcaaaaaa tcaggcaaag 35100
cctcgcgcaa aaaagaaagc acatcgtagt catgctcatg cagataaagg caggtaagct 35160
ccggaaccac cacagaaaaa gacaccattt ttctctcaaa catgtctgcg ggtttctgca 35220
taaacacaaa ataaaataac aaaaaaacat ttaaacatta gaagcctgtc ttacaacagg 35280
aaaaacaacc cttataagca taagacggac tacggccatg ccggcgtgac cgtaaaaaaa 35340
ctggtcaccg tgattaaaaa gcaccaccga cagctcctcg gtcatgtccg gagtcataat 35400
gtaagactcg gtaaacacat caggttgatt cacatcggtc agtgctaaaa agcgaccgaa 35460
atagcccggg ggaatacata cccgcaggcg tagagacaac attacagccc ccataggagg 35520
tataacaaaa ttaataggag agaaaaacac ataaacacct gaaaaaccct cctgcctagg 35580
caaaatagca ccctcccgct ccagaacaac atacagcgct tccacagcgg cagccataac 35640
agtcagcctt accagtaaaa aagaaaacct attaaaaaaa caccactcga cacggcacca 35700
gctcaatcag tcacagtgta aaaaagggcc aagtgcagag cgagtatata taggactaaa 35760
aaatgacgta acggttaaag tccacaaaaa acacccagaa aaccgcacgc gaacctacgc 35820
ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg ttttcccacg 35880
ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt tactccgccc 35940
taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa ctccaccccc 36000
tcattatcat attggcttca atccaaaata aggtatatta ttgatgatgc ctccggggtc 36060
cactgcaatt a 36071
<210> 46
<211> 6698
<212> DNA
<213> 人工序列
<220>
<223> pAR-gRNA-Cas9-Amp
<400> 46
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac ctaattgcag 300
tggaccccgg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac 360
ttgaaaaagt ggcaccgagt cggtgctttt ttaagcttga attcgctagc taggtcttga 420
aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc 480
ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg tggcgcgggg 540
taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac 600
cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa 660
cacaggaccg gttctagagc caccatggac aagaagtaca gcatcggcct ggacatcggc 720
accaactctg tgggctgggc cgtgatcacc gacgagtaca aggtgcccag caagaaattc 780
aaggtgctgg gcaacaccga ccggcacagc atcaagaaga acctgatcgg agccctgctg 840
ttcgacagcg gcgaaacagc cgaggccacc cggctgaaga gaaccgccag aagaagatac 900
accagacgga agaaccggat ctgctatctg caagagatct tcagcaacga gatggccaag 960
gtggacgaca gcttcttcca cagactggaa gagtccttcc tggtggaaga ggataagaag 1020
cacgagcggc accccatctt cggcaacatc gtggacgagg tggcctacca cgagaagtac 1080
cccaccatct accacctgag aaagaaactg gtggacagca ccgacaaggc cgacctgcgg 1140
ctgatctatc tggccctggc ccacatgatc aagttccggg gccacttcct gatcgagggc 1200
gacctgaacc ccgacaacag cgacgtggac aagctgttca tccagctggt gcagacctac 1260
aaccagctgt tcgaggaaaa ccccatcaac gccagcggcg tggacgccaa ggccatcctg 1320
tctgccagac tgagcaagag cagacggctg gaaaatctga tcgcccagct gcccggcgag 1380
aagaagaatg gcctgttcgg aaacctgatt gccctgagcc tgggcctgac ccccaacttc 1440
aagagcaact tcgacctggc cgaggatgcc aaactgcagc tgagcaagga cacctacgac 1500
gacgacctgg acaacctgct ggcccagatc ggcgaccagt acgccgacct gtttctggcc 1560
gccaagaacc tgtccgacgc catcctgctg agcgacatcc tgagagtgaa caccgagatc 1620
accaaggccc ccctgagcgc ctctatgatc aagagatacg acgagcacca ccaggacctg 1680
accctgctga aagctctcgt gcggcagcag ctgcctgaga agtacaaaga gattttcttc 1740
gaccagagca agaacggcta cgccggctac attgacggcg gagccagcca ggaagagttc 1800
tacaagttca tcaagcccat cctggaaaag atggacggca ccgaggaact gctcgtgaag 1860
ctgaacagag aggacctgct gcggaagcag cggaccttcg acaacggcag catcccccac 1920
cagatccacc tgggagagct gcacgccatt ctgcggcggc aggaagattt ttacccattc 1980
ctgaaggaca accgggaaaa gatcgagaag atcctgacct tccgcatccc ctactacgtg 2040
ggccctctgg ccaggggaaa cagcagattc gcctggatga ccagaaagag cgaggaaacc 2100
atcaccccct ggaacttcga ggaagtggtg gacaagggcg cttccgccca gagcttcatc 2160
gagcggatga ccaacttcga taagaacctg cccaacgaga aggtgctgcc caagcacagc 2220
ctgctgtacg agtacttcac cgtgtataac gagctgacca aagtgaaata cgtgaccgag 2280
ggaatgagaa agcccgcctt cctgagcggc gagcagaaaa aggccatcgt ggacctgctg 2340
ttcaagacca accggaaagt gaccgtgaag cagctgaaag aggactactt caagaaaatc 2400
gagtgcttcg actccgtgga aatctccggc gtggaagatc ggttcaacgc ctccctgggc 2460
acataccacg atctgctgaa aattatcaag gacaaggact tcctggacaa tgaggaaaac 2520
gaggacattc tggaagatat cgtgctgacc ctgacactgt ttgaggacag agagatgatc 2580
gaggaacggc tgaaaaccta tgcccacctg ttcgacgaca aagtgatgaa gcagctgaag 2640
cggcggagat acaccggctg gggcaggctg agccggaagc tgatcaacgg catccgggac 2700
aagcagtccg gcaagacaat cctggatttc ctgaagtccg acggcttcgc caacagaaac 2760
ttcatgcagc tgatccacga cgacagcctg acctttaaag aggacatcca gaaagcccag 2820
gtgtccggcc agggcgatag cctgcacgag cacattgcca atctggccgg cagccccgcc 2880
attaagaagg gcatcctgca gacagtgaag gtggtggacg agctcgtgaa agtgatgggc 2940
cggcacaagc ccgagaacat cgtgatcgaa atggccagag agaaccagac cacccagaag 3000
ggacagaaga acagccgcga gagaatgaag cggatcgaag agggcatcaa agagctgggc 3060
agccagatcc tgaaagaaca ccccgtggaa aacacccagc tgcagaacga gaagctgtac 3120
ctgtactacc tgcagaatgg gcgggatatg tacgtggacc aggaactgga catcaaccgg 3180
ctgtccgact acgatgtgga ccatatcgtg cctcagagct ttctgaagga cgactccatc 3240
gacaacaagg tgctgaccag aagcgacaag aaccggggca agagcgacaa cgtgccctcc 3300
gaagaggtcg tgaagaagat gaagaactac tggcggcagc tgctgaacgc caagctgatt 3360
acccagagaa agttcgacaa tctgaccaag gccgagagag gcggcctgag cgaactggat 3420
aaggccggct tcatcaagag acagctggtg gaaacccggc agatcacaaa gcacgtggca 3480
cagatcctgg actcccggat gaacactaag tacgacgaga atgacaagct gatccgggaa 3540
gtgaaagtga tcaccctgaa gtccaagctg gtgtccgatt tccggaagga tttccagttt 3600
tacaaagtgc gcgagatcaa caactaccac cacgcccacg acgcctacct gaacgccgtc 3660
gtgggaaccg ccctgatcaa aaagtaccct aagctggaaa gcgagttcgt gtacggcgac 3720
tacaaggtgt acgacgtgcg gaagatgatc gccaagagcg agcaggaaat cggcaaggct 3780
accgccaagt acttcttcta cagcaacatc atgaactttt tcaagaccga gattaccctg 3840
gccaacggcg agatccggaa gcggcctctg atcgagacaa acggcgaaac cggggagatc 3900
gtgtgggata agggccggga ttttgccacc gtgcggaaag tgctgagcat gccccaagtg 3960
aatatcgtga aaaagaccga ggtgcagaca ggcggcttca gcaaagagtc tatcctgccc 4020
aagaggaaca gcgataagct gatcgccaga aagaaggact gggaccctaa gaagtacggc 4080
ggcttcgaca gccccaccgt ggcctattct gtgctggtgg tggccaaagt ggaaaagggc 4140
aagtccaaga aactgaagag tgtgaaagag ctgctgggga tcaccatcat ggaaagaagc 4200
agcttcgaga agaatcccat cgactttctg gaagccaagg gctacaaaga agtgaaaaag 4260
gacctgatca tcaagctgcc taagtactcc ctgttcgagc tggaaaacgg ccggaagaga 4320
atgctggcct ctgccggcga actgcagaag ggaaacgaac tggccctgcc ctccaaatat 4380
gtgaacttcc tgtacctggc cagccactat gagaagctga agggctcccc cgaggataat 4440
gagcagaaac agctgtttgt ggaacagcac aagcactacc tggacgagat catcgagcag 4500
atcagcgagt tctccaagag agtgatcctg gccgacgcta atctggacaa agtgctgtcc 4560
gcctacaaca agcaccggga taagcccatc agagagcagg ccgagaatat catccacctg 4620
tttaccctga ccaatctggg agcccctgcc gccttcaagt actttgacac caccatcgac 4680
cggaagaggt acaccagcac caaagaggtg ctggacgcca ccctgatcca ccagagcatc 4740
accggcctgt acgagacacg gatcgacctg tctcagctgg gaggcgacaa gcgacctgcc 4800
gccacaaaga aggctggaca ggctaagaag aagaaagatt acaaagacga tgacgataag 4860
tgactcgagt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt 4920
ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa 4980
taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt 5040
tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat 5100
gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag 5160
atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg 5220
ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata 5280
cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat 5340
ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc 5400
aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg 5460
ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac 5520
gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact 5580
ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa 5640
gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct 5700
ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc 5760
tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga 5820
cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac 5880
tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag 5940
atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg 6000
tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc 6060
tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag 6120
ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc 6180
cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac 6240
ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc 6300
gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt 6360
tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt 6420
gagcattgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc 6480
ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt 6540
tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca 6600
ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt 6660
tgctggcctt ttgctcacat gttctttcct gcgatgca 6698
<210> 47
<211> 2233
<212> DNA
<213> 人工序列
<220>
<223> pAR-gRNA-Ex
<400> 47
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac ctaattgcag 300
tggaccccgg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac 360
ttgaaaaagt ggcaccgagt cggtgctttt ttaagcttga attcgcaggt ggcacttttc 420
ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc 480
cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga 540
gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt 600
ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag 660
tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag 720
aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta 780
ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg 840
agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca 900
gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag 960
gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc 1020
gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg 1080
tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc 1140
ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg 1200
cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg 1260
gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga 1320
cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac 1380
tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa 1440
aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca 1500
aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag 1560
gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac 1620
cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa 1680
ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc 1740
accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag 1800
tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac 1860
cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc 1920
gaacgaccta caccgaactg agatacctac agcgtgagca ttgagaaagc gccacgcttc 1980
ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca 2040
cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc 2100
tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg 2160
ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct 2220
ttcctgcgat gca 2233
<210> 48
<211> 2234
<212> DNA
<213> 人工序列
<220>
<223> pAR-gRNA-IntC5
<400> 48
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac ctatattatt 300
gatgatgcct cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa 360
cttgaaaaag tggcaccgag tcggtgcttt tttaagcttg aattcgcagg tggcactttt 420
cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat 480
ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg 540
agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt 600
tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga 660
gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa 720
gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt 780
attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt 840
gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc 900
agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga 960
ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat 1020
cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct 1080
gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc 1140
cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg 1200
gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc 1260
ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg 1320
acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca 1380
ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta 1440
aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc 1500
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 1560
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 1620
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 1680
actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 1740
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 1800
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 1860
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 1920
cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt 1980
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 2040
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 2100
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 2160
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 2220
tttcctgcga tgca 2234
<210> 49
<211> 2233
<212> DNA
<213> 人工序列
<220>
<223> pAR-gRNA-IntD64
<400> 49
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac cattattaga 300
tagttaatta gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac 360
ttgaaaaagt ggcaccgagt cggtgctttt ttaagcttga attcgcaggt ggcacttttc 420
ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc 480
cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga 540
gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt 600
ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag 660
tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag 720
aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta 780
ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg 840
agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca 900
gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag 960
gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc 1020
gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg 1080
tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc 1140
ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg 1200
cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg 1260
gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga 1320
cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac 1380
tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa 1440
aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca 1500
aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag 1560
gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac 1620
cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa 1680
ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc 1740
accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag 1800
tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac 1860
cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc 1920
gaacgaccta caccgaactg agatacctac agcgtgagca ttgagaaagc gccacgcttc 1980
ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca 2040
cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc 2100
tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg 2160
ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct 2220
ttcctgcgat gca 2233
<210> 50
<211> 8258
<212> DNA
<213> 人工序列
<220>
<223> pSG5-Cas9
<400> 50
gtcgacttct gaggcggaaa gaaccagctg tggaatgtgt gtcagttagg gtgtggaaag 60
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 120
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 180
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 240
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 300
gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 360
tgcaaaaagc tggatcgatc ctgagaactt cagggtgagt ttggggaccc ttgattgttc 420
tttctttttc gctattgtaa aattcatgtt atatggaggg ggcaaagttt tcagggtgtt 480
gtttagaatg ggaagatgtc ccttgtatca ccatggaccc tcatgataat tttgtttctt 540
tcactttcta ctctgttgac aaccattgtc tcctcttatt ttcttttcat tttctgtaac 600
tttttcgtta aactttagct tgcatttgta acgaattttt aaattcactt ttgtttattt 660
gtcagattgt aagtactttc tctaatcact tttttttcaa ggcaatcagg gtatattata 720
ttgtacttca gcacagtttt agagaacaat tgttataatt aaatgataag gtagaatatt 780
tctgcatata aattctggct ggcgtggaaa tattcttatt ggtagaaaca actacatcct 840
ggtcatcatc ctgcctttct ctttatggtt acaatgatat acactgtttg agatgaggat 900
aaaatactct gagtccaaac cgggcccctc tgctaaccat gttcatgcct tcttcttttt 960
cctacagctc ctgggcaacg tgctggttat tgtgctgtct catcattttg gcaaagaatt 1020
gtaatacgac tcactatagg gcgaattcat ggacaagaag tacagcatcg gcctggacat 1080
cggcaccaac tctgtgggct gggccgtgat caccgacgag tacaaggtgc ccagcaagaa 1140
attcaaggtg ctgggcaaca ccgaccggca cagcatcaag aagaacctga tcggagccct 1200
gctgttcgac agcggcgaaa cagccgaggc cacccggctg aagagaaccg ccagaagaag 1260
atacaccaga cggaagaacc ggatctgcta tctgcaagag atcttcagca acgagatggc 1320
caaggtggac gacagcttct tccacagact ggaagagtcc ttcctggtgg aagaggataa 1380
gaagcacgag cggcacccca tcttcggcaa catcgtggac gaggtggcct accacgagaa 1440
gtaccccacc atctaccacc tgagaaagaa actggtggac agcaccgaca aggccgacct 1500
gcggctgatc tatctggccc tggcccacat gatcaagttc cggggccact tcctgatcga 1560
gggcgacctg aaccccgaca acagcgacgt ggacaagctg ttcatccagc tggtgcagac 1620
ctacaaccag ctgttcgagg aaaaccccat caacgccagc ggcgtggacg ccaaggccat 1680
cctgtctgcc agactgagca agagcagacg gctggaaaat ctgatcgccc agctgcccgg 1740
cgagaagaag aatggcctgt tcggaaacct gattgccctg agcctgggcc tgacccccaa 1800
cttcaagagc aacttcgacc tggccgagga tgccaaactg cagctgagca aggacaccta 1860
cgacgacgac ctggacaacc tgctggccca gatcggcgac cagtacgccg acctgtttct 1920
ggccgccaag aacctgtccg acgccatcct gctgagcgac atcctgagag tgaacaccga 1980
gatcaccaag gcccccctga gcgcctctat gatcaagaga tacgacgagc accaccagga 2040
cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct gagaagtaca aagagatttt 2100
cttcgaccag agcaagaacg gctacgccgg ctacattgac ggcggagcca gccaggaaga 2160
gttctacaag ttcatcaagc ccatcctgga aaagatggac ggcaccgagg aactgctcgt 2220
gaagctgaac agagaggacc tgctgcggaa gcagcggacc ttcgacaacg gcagcatccc 2280
ccaccagatc cacctgggag agctgcacgc cattctgcgg cggcaggaag atttttaccc 2340
attcctgaag gacaaccggg aaaagatcga gaagatcctg accttccgca tcccctacta 2400
cgtgggccct ctggccaggg gaaacagcag attcgcctgg atgaccagaa agagcgagga 2460
aaccatcacc ccctggaact tcgaggaagt ggtggacaag ggcgcttccg cccagagctt 2520
catcgagcgg atgaccaact tcgataagaa cctgcccaac gagaaggtgc tgcccaagca 2580
cagcctgctg tacgagtact tcaccgtgta taacgagctg accaaagtga aatacgtgac 2640
cgagggaatg agaaagcccg ccttcctgag cggcgagcag aaaaaggcca tcgtggacct 2700
gctgttcaag accaaccgga aagtgaccgt gaagcagctg aaagaggact acttcaagaa 2760
aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa gatcggttca acgcctccct 2820
gggcacatac cacgatctgc tgaaaattat caaggacaag gacttcctgg acaatgagga 2880
aaacgaggac attctggaag atatcgtgct gaccctgaca ctgtttgagg acagagagat 2940
gatcgaggaa cggctgaaaa cctatgccca cctgttcgac gacaaagtga tgaagcagct 3000
gaagcggcgg agatacaccg gctggggcag gctgagccgg aagctgatca acggcatccg 3060
ggacaagcag tccggcaaga caatcctgga tttcctgaag tccgacggct tcgccaacag 3120
aaacttcatg cagctgatcc acgacgacag cctgaccttt aaagaggaca tccagaaagc 3180
ccaggtgtcc ggccagggcg atagcctgca cgagcacatt gccaatctgg ccggcagccc 3240
cgccattaag aagggcatcc tgcagacagt gaaggtggtg gacgagctcg tgaaagtgat 3300
gggccggcac aagcccgaga acatcgtgat cgaaatggcc agagagaacc agaccaccca 3360
gaagggacag aagaacagcc gcgagagaat gaagcggatc gaagagggca tcaaagagct 3420
gggcagccag atcctgaaag aacaccccgt ggaaaacacc cagctgcaga acgagaagct 3480
gtacctgtac tacctgcaga atgggcggga tatgtacgtg gaccaggaac tggacatcaa 3540
ccggctgtcc gactacgatg tggaccatat cgtgcctcag agctttctga aggacgactc 3600
catcgacaac aaggtgctga ccagaagcga caagaaccgg ggcaagagcg acaacgtgcc 3660
ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg cagctgctga acgccaagct 3720
gattacccag agaaagttcg acaatctgac caaggccgag agaggcggcc tgagcgaact 3780
ggataaggcc ggcttcatca agagacagct ggtggaaacc cggcagatca caaagcacgt 3840
ggcacagatc ctggactccc ggatgaacac taagtacgac gagaatgaca agctgatccg 3900
ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc gatttccgga aggatttcca 3960
gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc cacgacgcct acctgaacgc 4020
cgtcgtggga accgccctga tcaaaaagta ccctaagctg gaaagcgagt tcgtgtacgg 4080
cgactacaag gtgtacgacg tgcggaagat gatcgccaag agcgagcagg aaatcggcaa 4140
ggctaccgcc aagtacttct tctacagcaa catcatgaac tttttcaaga ccgagattac 4200
cctggccaac ggcgagatcc ggaagcggcc tctgatcgag acaaacggcg aaaccgggga 4260
gatcgtgtgg gataagggcc gggattttgc caccgtgcgg aaagtgctga gcatgcccca 4320
agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc ttcagcaaag agtctatcct 4380
gcccaagagg aacagcgata agctgatcgc cagaaagaag gactgggacc ctaagaagta 4440
cggcggcttc gacagcccca ccgtggccta ttctgtgctg gtggtggcca aagtggaaaa 4500
gggcaagtcc aagaaactga agagtgtgaa agagctgctg gggatcacca tcatggaaag 4560
aagcagcttc gagaagaatc ccatcgactt tctggaagcc aagggctaca aagaagtgaa 4620
aaaggacctg atcatcaagc tgcctaagta ctccctgttc gagctggaaa acggccggaa 4680
gagaatgctg gcctctgccg gcgaactgca gaagggaaac gaactggccc tgccctccaa 4740
atatgtgaac ttcctgtacc tggccagcca ctatgagaag ctgaagggct cccccgagga 4800
taatgagcag aaacagctgt ttgtggaaca gcacaagcac tacctggacg agatcatcga 4860
gcagatcagc gagttctcca agagagtgat cctggccgac gctaatctgg acaaagtgct 4920
gtccgcctac aacaagcacc gggataagcc catcagagag caggccgaga atatcatcca 4980
cctgtttacc ctgaccaatc tgggagcccc tgccgccttc aagtactttg acaccaccat 5040
cgaccggaag aggtacacca gcaccaaaga ggtgctggac gccaccctga tccaccagag 5100
catcaccggc ctgtacgaga cacggatcga cctgtctcag ctgggaggcg acaagcgacc 5160
tgccgccaca aagaaggctg gacaggctaa gaagaagaaa gattacaaag acgatgacga 5220
taagtgactc gagtaaggat cttattaaag cagaacttgt ttattgcagc ttataatggt 5280
tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 5340
agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggtcgac tctagactct 5400
tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca 5460
gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac 5520
atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt 5580
ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg 5640
cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc 5700
tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc 5760
gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc 5820
aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac 5880
tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt 5940
aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct 6000
aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc 6060
ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt 6120
ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg 6180
atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc 6240
atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa 6300
tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag 6360
gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg 6420
tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga 6480
gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag 6540
cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa 6600
gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc 6660
atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca 6720
aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg 6780
atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat 6840
aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc 6900
aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg 6960
gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg 7020
gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt 7080
gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca 7140
ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata 7200
ctcttctttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac 7260
atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa 7320
gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt 7380
atcacgaggc ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat 7440
gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg 7500
tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga 7560
gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat gcgtaaggag 7620
aaaataccgc atcaggaaat tgtaaacgtt aatattttgt taaaattcgc gttaaatttt 7680
tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca 7740
aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta 7800
aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta 7860
cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg 7920
aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga 7980
aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg 8040
ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtcgcgccat 8100
tcgccattca ggctacgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta 8160
cgccagctgg cgaagggggg atgtgctgca aggcgattaa gttgggtaac gccagggttt 8220
tcccagtcac gacgttgtaa aacgacggcc agtgaatt 8258
<210> 51
<211> 41235
<212> DNA
<213> 人工序列
<220>
<223> pBAd5-mChe
<400> 51
aaaaaaaagc ccgccgaagc gggctttatt tagcttcctt agctcctgaa aatctcgata 60
actcaaaaaa tacgcccggt agtgatctta tttcattatg gtgaaagttg gaacctctta 120
cgtgccgatc aacgtctcat tttcgccaaa agttggccca gggcttcccg gtatcaacag 180
ggacaccagg atttatttat tctgcgaagt gatcttccgt cacaggtatt tattcgcgat 240
aagctcatgg agcggcgtaa ccgtcgcaca ggaaggacag agaaagcgcg gatctgggaa 300
gtgacggaca gaacggtcag gacctggatt ggggaggcgg ttgccgccgc tgctgctgac 360
ggtgtgacgt tctctgttcc ggtcacacca catacgttcc gccattccta tgcgatgcac 420
atgctgtatg ccggtatacc gctgaaagtt ctgcaaagcc tgatgggaca taagtccatc 480
agttcaacgg aagtctacac gaaggttttt gcgctggatg tggctgcccg gcaccgggtg 540
cagtttgcga tgccggagtc tgatgcggtt gcgatgctga aacaattatc ctgagaataa 600
atgccttggc ctttatatgg aaatgtggaa ctgagtggat atgctgtttt tgtctgttaa 660
acagagaagc tggctgttat ccactgagaa gcgaacgaaa cagtcgggaa aatctcccat 720
tatcgtagag atccgcatta ttaatctcag gagcctgtgt agcgtttata ggaagtagtg 780
ttctgtcatg atgcctgcaa gcggtaacga aaacgatttg aatatgcctt caggaacaat 840
agaaatcttc gtgcggtgtt acgttgaagt ggagcggatt atgtcagcaa tggacagaac 900
aacctaatga acacagaacc atgatgtggt ctgtcctttt acagccagta ggctcgccgc 960
agtcgagcga cggcgaagcc ctcgagtgag cgaggaagca ccagggaaca gcacttatat 1020
attctgctta cacacgatgc ctgaaaaaac ttcccttggg gttatccact tatccacggg 1080
gatattttta taattatttt ttttatagtt tttagatctt cttttttaga gcgccttgta 1140
ggcctttatc catgctggtt ctagagaagg tgttgtgaca aattgccctt tcagtgtgac 1200
aaatcaccct caaatgacag tcctgtctgt gacaaattgc ccttaaccct gtgacaaatt 1260
gccctcagaa gaagctgttt tttcacaaag ttatccctgc ttattgactc ttttttattt 1320
agtgtgacaa tctaaaaact tgtcacactt cacatggatc tgtcatggcg gaaacagcgg 1380
ttatcaatca caagaaacgt aaaaatagcc cgcgaatcgt ccagtcaaac gacctcactg 1440
aggcggcata tagtctctcc cgggatcaaa aacgtatgct gtatctgttc gttgaccaga 1500
tcagaaaatc tgatggcacc ctacaggaac atgacggtat ctgcgagatc catgttgcta 1560
aatatgctga aatattcgga ttgacctctg cggaagccag taaggatata cggcaggcat 1620
tgaagagttt cgcggggaag gaagtggttt tttatcgccc tgaagaggat gccggcgatg 1680
aaaaaggcta tgaatctttt ccttggttta tcaaacgtgc gcacagtcca tccagagggc 1740
tttacagtgt acatatcaac ccatatctca ttcccttctt tatcgggtta cagaaccggt 1800
ttacgcagtt tcggcttagt gaaacaaaag aaatcaccaa tccgtatgcc atgcgtttat 1860
acgaatccct gtgtcagtat cgtaagccgg atggctcagg catcgtctct ctgaaaatcg 1920
actggatcat agagcgttac cagctgcctc aaagttacca gcgtatgcct gacttccgcc 1980
gccgcttcct gcaggtctgt gttaatgaga tcaacagcag aactccaatg cgcctctcat 2040
acattgagaa aaagaaaggc cgccagacga ctcatatcgt attttccttc cgcgatatca 2100
cttccatgac gacaggatag tctgagggtt atctgtcaca gatttgaggg tggttcgtca 2160
catttgttct gacctactga gggtaatttg tcacagtttt gctgtttcct tcagcctgca 2220
tggattttct catacttttt gaactgtaat ttttaaggaa gccaaatttg agggcagttt 2280
gtcacagttg atttccttct ctttcccttc gtcatgtgac ctgatatcgg gggttagttc 2340
gtcatcattg atgagggttg attatcacag tttattactc tgaattggct atccgcgtgt 2400
gtacctctac ctggagtttt tcccacggtg gatatttctt cttgcgctga gcgtaagagc 2460
tatctgacag aacagttctt ctttgcttcc tcgccagttc gctcgctatg ctcggttaca 2520
cggctgcggc gagcgctagt gataataagt gactgaggta tgtgctcttc ttatctcctt 2580
ttgtagtgtt gctcttattt taaacaactt tgcggttttt tgatgacttt gcgattttgt 2640
tgttgctttg cagtaaattg caagatttaa taaaaaaacg caaagcaatg attaaaggat 2700
gttcagaatg aaactcatgg aaacacttaa ccagtgcata aacgctggtc atgaaatgac 2760
gaaggctatc gccattgcac agtttaatga tgacagcccg gaagcgagga aaataacccg 2820
gcgctggaga ataggtgaag cagcggattt agttggggtt tcttctcagg ctatcagaga 2880
tgccgagaaa gcagggcgac taccgcaccc ggatatggaa attcgaggac gggttgagca 2940
acgtgttggt tatacaattg aacaaattaa tcatatgcgt gatgtgtttg gtacgcgatt 3000
gcgacgtgct gaagacgtat ttccaccggt gatcggggtt gctgcccata aaggtggcgt 3060
ttacaaaacc tcagtttctg ttcatcttgc tcaggatctg gctctgaagg ggctacgtgt 3120
tttgctcgtg gaaggtaacg acccccaggg aacagcctca atgtatcacg gatgggtacc 3180
agatcttcat attcatgcag aagacactct cctgcctttc tatcttgggg aaaaggacga 3240
tgtcacttat gcaataaagc ccacttgctg gccggggctt gacattattc cttcctgtct 3300
ggctctgcac cgtattgaaa ctgagttaat gggcaaattt gatgaaggta aactgcccac 3360
cgatccacac ctgatgctcc gactggccat tgaaactgtt gctcatgact atgatgtcat 3420
agttattgac agcgcgccta acctgggtat cggcacgatt aatgtcgtat gtgctgctga 3480
tgtgctgatt gttcccacgc ctgctgagtt gtttgactac acctccgcac tgcagttttt 3540
cgatatgctt cgtgatctgc tcaagaacgt tgatcttaaa gggttcgagc ctgatgtacg 3600
tattttgctt accaaataca gcaatagtaa tggctctcag tccccgtgga tggaggagca 3660
aattcgggat gcctggggaa gcatggttct aaaaaatgtt gtacgtgaaa cggatgaagt 3720
tggtaaaggt cagatccgga tgagaactgt ttttgaacag gccattgatc aacgctcttc 3780
aactggtgcc tggagaaatg ctctttctat ttgggaacct gtctgcaatg aaattttcga 3840
tcgtctgatt aaaccacgct gggagattag ataatgaagc gtgcgcctgt tattccaaaa 3900
catacgctca atactcaacc ggttgaagat acttcgttat cgacaccagc tgccccgatg 3960
gtggattcgt taattgcgcg cgtaggagta atggctcgcg gtaatgccat tactttgcct 4020
gtatgtggtc gggatgtgaa gtttactctt gaagtgctcc ggggtgatag tgttgagaag 4080
acctctcggg tatggtcagg taatgaacgt gaccaggagc tgcttactga ggacgcactg 4140
gatgatctca tcccttcttt tctactgact ggtcaacaga caccggcgtt cggtcgaaga 4200
gtatctggtg tcatagaaat tgccgatggg agtcgccgtc gtaaagctgc tgcacttacc 4260
gaaagtgatt atcgtgttct ggttggcgag ctggatgatg agcagatggc tgcattatcc 4320
agattgggta acgattatcg cccaacaagt gcttatgaac gtggtcagcg ttatgcaagc 4380
cgattgcaga atgaatttgc tggaaatatt tctgcgctgg ctgatgcgga aaatatttca 4440
cgtaagatta ttacccgctg tatcaacacc gccaaattgc ctaaatcagt tgttgctctt 4500
ttttctcacc ccggtgaact atctgcccgg tcaggtgatg cacttcaaaa agcctttaca 4560
gataaagagg aattacttaa gcagcaggca tctaaccttc atgagcagaa aaaagctggg 4620
gtgatatttg aagctgaaga agttatcact cttttaactt ctgtgcttaa aacgtcatct 4680
gcatcaagaa ctagtttaag ctcacgacat cagtttgctc ctggagcgac agtattgtat 4740
aagggcgata aaatggtgct taacctggac aggtctcgtg ttccaactga gtgtatagag 4800
aaaattgagg ccattcttaa ggaacttgaa aagccagcac cctgatgcga ccacgtttta 4860
gtctacgttt atctgtcttt acttaatgtc ctttgttaca ggccagaaag cataactggc 4920
ctgaatattc tctctgggcc cactgttcca cttgtatcgt cggtctgata atcagactgg 4980
gaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 5040
tatcgtcggt ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgataa 5100
tcagactggg accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccatgg 5160
tcccactcgt atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg 5220
gtctgattat tagtctggaa ccacggtccc actcgtatcg tcggtctgat tattagtctg 5280
ggaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccac gatcccactc 5340
gtgttgtcgg tctgattatc ggtctgggac cacggtccca cttgtattgt cgatcagact 5400
atcagcgtga gactacgatt ccatcaatgc ctgtcaaggg caagtattga catgtcgtcg 5460
taacctgtag aacggagtaa cctcggtgtg cggttgtatg cctgctgtgg attgctgctg 5520
tgtcctgctt atccacaaca ttttgcgcac ggttatgtgg acaaaatacc tggttaccca 5580
ggccgtgccg gcacgttaac cgggctgcat ccgatgcaag tgtgtcgctg tcgagttttc 5640
gggggagtcc agggttttcc cagtcacgac gttgtaaaac gacggccagt gaattcgagc 5700
tcggtacccg gggatcttga agttcctatt ctctagaaag tataggaact tcaattccca 5760
tgtcagccgt taagtgttcc tgtgtcactc aaaattgctt tgagaggctc taagggcttc 5820
tcagtgcgtt acatccctgg cttgttgtcc acaaccgtta aaccttaaaa gctttaaaag 5880
ccttatatat tctttttttt cttataaaac ttaaaacctt agaggctatt taagttgctg 5940
atttatatta attttattgt tcaaacatga gagcttagta cgtgaaacat gagagcttag 6000
tacgttagcc atgagagctt agtacgttag ccatgagggt ttagttcgtt aaacatgaga 6060
gcttagtacg ttaaacatga gagcttagta cgtgaaacat gagagcttag tacgtactat 6120
caacaggttg aactgctgat cttcagatcc tctacgccgg acgcatcgtg gccttaatta 6180
acatatggat ttattcaaca aagccacgtt gtgtctcaaa atctctgatg ttacattgca 6240
caagataaaa atatatcatc atgaacaata aaactgtctg cttacataaa cagtaataca 6300
aggggtgtta tgagccatat tcaacgggaa acgtcttgct cgaggccgcg attaaattcc 6360
aacatggatg ctgatttata tgggtataaa tgggctcgcg ataatgtcgg gcaatcaggt 6420
gcgacaatct atcgattgta tgggaagccc gatgcgccag agttgtttct gaaacatggc 6480
aaaggtagcg ttgccaatga tgttacagat gagatggtca gactaaactg gctgacggaa 6540
tttatgcctc ttccgaccat caagcatttt atccgtactc ctgatgatgc atggttactc 6600
accactgcga tccccgggaa aacagcattc caggtattag aagaatatcc tgattcaggt 6660
gaaaatattg ttgatgcgct ggcagtgttc ctgcgccggt tgcattcgat tcctgtttgt 6720
aattgtcctt ttaacagcga tcgcgtattt cgtctcgctc aggcgcaatc acgaatgaat 6780
aacggtttgg ttgatgcgag tgattttgat gacgagcgta atggctggcc tgttgaacaa 6840
gtctggaaag aaatgcataa gcttttgcca ttctcaccgg attcagtcgt cactcatggt 6900
gatttctcac ttgataacct tatttttgac gaggggaaat taataggttg tattgatgtt 6960
ggacgagtcg gaatcgcaga ccgataccag gatcttgcca tcctatggaa ctgcctcggt 7020
gagttttctc cttcattaca gaaacggctt tttcaaaaat atggtattga taatcctgat 7080
atgaataaat tgcagtttca tttgatgctc gatgagtttt tctaatcaga attggttaat 7140
tggttgtaac actgggcatg ccatcatcaa taatatacct tattttggat tgaagccaat 7200
atgataatga gggggtggag tttgtgacgt ggcgcggggc gtgggaacgg ggcgggtgac 7260
gtagtagtgt ggcggaagtg tgatgttgca agtgtggcgg aacacatgta agcgacggat 7320
gtggcaaaag tgacgttttt ggtgtgcgcc ggtgtacaca ggaagtgaca attttcgcgc 7380
ggttttaggc ggatgttgta gtaaatttgg gcgtaaccga gtaagatttg gccattttcg 7440
cgggaaaact gaataagagg aagtgaaatc tgaataattt tgtgttactc atagcgcgta 7500
ataatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac 7560
ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 7620
aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 7680
ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac 7740
gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 7800
cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt 7860
gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc 7920
aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 7980
tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 8040
ggaggtctat ataagcagag ctggtttagt gaaccgtcag atccgctagc gctaccggac 8100
tcagatctcg agctcaagct tcgaattctg cagtcgacgg taccgagctc ggatcccgcc 8160
accatggtga gcaagggcga ggaggataac atggccatca tcaaggagtt catgcgcttc 8220
aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag 8280
ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg tggccccctg 8340
cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag 8400
caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag 8460
cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag 8520
gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc 8580
gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac 8640
ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac 8700
gctgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac 8760
gtcaacatca agttggacat cacctcccac aacgaggact acaccatcgt ggaacagtac 8820
gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaagaattc 8880
tgcagatatc cagcacagtg gcggccgcga ctctagatca taatcagcca taccacattt 8940
gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 9000
atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 9060
aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 9120
tccaaactca tcaatgtatc ttaaatcgaa ttcaagcttg tcgactcgaa gatctgagct 9180
cacgcgtgaa gttcctattc cgaagttcct attctctaga aagtatagga acttcagagc 9240
gcttttgaag ctggggtggg cgaagaactc cagcatgaga tccccagagc gcttttgaag 9300
ctgcgtttaa acgcgatatc ccgggagctc ccgatatcgc gtttaaacgc agcttggcgt 9360
aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca 9420
tacgagccgg aagactgaaa tgtgtgggcg tggcttaagg gtgggaaaga atatataagg 9480
tgggggtctt atgtagtttt gtatctgttt tgcagcagcc gccgccgcca tgagcaccaa 9540
ctcgtttgat ggaagcattg tgagctcata tttgacaacg cgcatgcccc catgggccgg 9600
ggtgcgtcag aatgtgatgg gctccagcat tgatggtcgc cccgtcctgc ccgcaaactc 9660
tactaccttg acctacgaga ccgtgtctgg aacgccgttg gagactgcag cctccgccgc 9720
cgcttcagcc gctgcagcca ccgcccgcgg gattgtgact gactttgctt tcctgagccc 9780
gcttgcaagc agtgcagctt cccgttcatc cgcccgcgat gacaagttga cggctctttt 9840
ggcacaattg gattctttga cccgggaact taatgtcgtt tctcagcagc tgttggatct 9900
gcgccagcag gtttctgccc tgaaggcttc ctcccctccc aatgcggttt aaaacataaa 9960
taaaaaacca gactctgttt ggatttggat caagcaagtg tcttgctgtc tttatttagg 10020
ggttttgcgc gcgcggtagg cccgggacca gcggtctcgg tcgttgaggg tcctgtgtat 10080
tttttccagg acgtggtaaa ggtgactctg gatgttcaga tacatgggca taagcccgtc 10140
tctggggtgg aggtagcacc actgcagagc ttcatgctgc ggggtggtgt tgtagatgat 10200
ccagtcgtag caggagcgct gggcgtggtg cctaaaaatg tctttcagta gcaagctgat 10260
tgccaggggc aggcccttgg tgtaagtgtt tacaaagcgg ttaagctggg atgggtgcat 10320
acgtggggat atgagatgca tcttggactg tatttttagg ttggctatgt tcccagccat 10380
atccctccgg ggattcatgt tgtgcagaac caccagcaca gtgtatccgg tgcacttggg 10440
aaatttgtca tgtagcttag aaggaaatgc gtggaagaac ttggagacgc ccttgtgacc 10500
tccaagattt tccatgcatt cgtccataat gatggcaatg ggcccacggg cggcggcctg 10560
ggcgaagata tttctgggat cactaacgtc atagttgtgt tccaggatga gatcgtcata 10620
ggccattttt acaaagcgcg ggcggagggt gccagactgc ggtataatgg ttccatccgg 10680
cccaggggcg tagttaccct cacagatttg catttcccac gctttgagtt cagatggggg 10740
gatcatgtct acctgcgggg cgatgaagaa aacggtttcc ggggtagggg agatcagctg 10800
ggaagaaagc aggttcctga gcagctgcga cttaccgcag ccggtgggcc cgtaaatcac 10860
acctattacc gggtgcaact ggtagttaag agagctgcag ctgccgtcat ccctgagcag 10920
gggggccact tcgttaagca tgtccctgac tcgcatgttt tccctgacca aatccgccag 10980
aaggcgctcg ccgcccagcg atagcagttc ttgcaaggaa gcaaagtttt tcaacggttt 11040
gagaccgtcc gccgtaggca tgcttttgag cgtttgacca agcagttcca ggcggtccca 11100
cagctcggtc acctgctcta cggcatctcg atccagcata tctcctcgtt tcgcgggttg 11160
gggcggcttt cgctgtacgg cagtagtcgg tgctcgtcca gacgggccag ggtcatgtct 11220
ttccacgggc gcagggtcct cgtcagcgta gtctgggtca cggtgaaggg gtgcgctccg 11280
ggctgcgcgc tggccagggt gcgcttgagg ctggtcctgc tggtgctgaa gcgctgccgg 11340
tcttcgccct gcgcgtcggc caggtagcat ttgaccatgg tgtcatagtc cagcccctcc 11400
gcggcgtggc ccttggcgcg cagcttgccc ttggaggagg cgccgcacga ggggcagtgc 11460
agacttttga gggcgtagag cttgggcgcg agaaataccg attccgggga gtaggcatcc 11520
gcgccgcagg ccccgcagac ggtctcgcat tccacgagcc aggtgagctc tggccgttcg 11580
gggtcaaaaa ccaggtttcc cccatgcttt ttgatgcgtt tcttacctct ggtttccatg 11640
agccggtgtc cacgctcggt gacgaaaagg ctgtccgtgt ccccgtatac agacttgaga 11700
ggcctgtcct cgagcggtgt tccgcggtcc tcctcgtata gaaactcgga ccactctgag 11760
acaaaggctc gcgtccaggc cagcacgaag gaggctaagt gggaggggta gcggtcgttg 11820
tccactaggg ggtccactcg ctccagggtg tgaagacaca tgtcgccctc ttcggcatca 11880
aggaaggtga ttggtttgta ggtgtaggcc acgtgaccgg gtgttcctga aggggggcta 11940
taaaaggggg tgggggcgcg ttcgtcctca ctctcttccg catcgctgtc tgcgagggcc 12000
agctgttggg gtgagtactc cctctgaaaa gcgggcatga cttctgcgct aagattgtca 12060
gtttccaaaa acgaggagga tttgatattc acctggcccg cggtgatgcc tttgagggtg 12120
gccgcatcca tctggtcaga aaagacaatc tttttgttgt caagcttggt ggcaaacgac 12180
ccgtagaggg cgttggacag caacttggcg atggagcgca gggtttggtt tttgtcgcga 12240
tcggcgcgct ccttggccgc gatgtttagc tgcacgtatt cgcgcgcaac gcaccgccat 12300
tcgggaaaga cggtggtgcg ctcgtcgggc accaggtgca cgcgccaacc gcggttgtgc 12360
agggtgacaa ggtcaacgct ggtggctacc tctccgcgta ggcgctcgtt ggtccagcag 12420
aggcggccgc ccttgcgcga gcagaatggc ggtagggggt ctagctgcgt ctcgtccggg 12480
gggtctgcgt ccacggtaaa gaccccgggc agcaggcgcg cgtcgaagta gtctatcttg 12540
catccttgca agtctagcgc ctgctgccat gcgcgggcgg caagcgcgcg ctcgtatggg 12600
ttgagtgggg gaccccatgg catggggtgg gtgagcgcgg aggcgtacat gccgcaaatg 12660
tcgtaaacgt agaggggctc tctgagtatt ccaagatatg tagggtagca tcttccaccg 12720
cggatgctgg cgcgcacgta atcgtatagt tcgtgcgagg gagcgaggag gtcgggaccg 12780
aggttgctac gggcgggctg ctctgctcgg aagactatct gcctgaagat ggcatgtgag 12840
ttggatgata tggttggacg ctggaagacg ttgaagctgg cgtctgtgag acctaccgcg 12900
tcacgcacga aggaggcgta ggagtcgcgc agcttgttga ccagctcggc ggtgacctgc 12960
acgtctaggg cgcagtagtc cagggtttcc ttgatgatgt catacttatc ctgtcccttt 13020
tttttccaca gctcgcggtt gaggacaaac tcttcgcggt ctttccagta ctcttggatc 13080
ggaaacccgt cggcctccga acggtaagag cctagcatgt agaactggtt gacggcctgg 13140
taggcgcagc atcccttttc tacgggtagc gcgtatgcct gcgcggcctt ccggagcgag 13200
gtgtgggtga gcgcaaaggt gtccctgacc atgactttga ggtactggta tttgaagtca 13260
gtgtcgtcgc atccgccctg ctcccagagc aaaaagtccg tgcgcttttt ggaacgcgga 13320
tttggcaggg cgaaggtgac atcgttgaag agtatctttc ccgcgcgagg cataaagttg 13380
cgtgtgatgc ggaagggtcc cggcacctcg gaacggttgt taattacctg ggcggcgagc 13440
acgatctcgt caaagccgtt gatgttgtgg cccacaatgt aaagttccaa gaagcgcggg 13500
atgcccttga tggaaggcaa ttttttaagt tcctcgtagg tgagctcttc aggggagctg 13560
agcccgtgct ctgaaagggc ccagtctgca agatgagggt tggaagcgac gaatgagctc 13620
cacaggtcac gggccattag catttgcagg tggtcgcgaa aggtcctaaa ctggcgacct 13680
atggccattt tttctggggt gatgcagtag aaggtaagcg ggtcttgttc ccagcggtcc 13740
catccaaggt tcgcggctag gtctcgcgcg gcagtcacta gaggctcatc tccgccgaac 13800
ttcatgacca gcatgaaggg cacgagctgc ttcccaaagg cccccatcca agtataggtc 13860
tctacatcgt aggtgacaaa gagacgctcg gtgcgaggat gcgagccgat cgggaagaac 13920
tggatctccc gccaccaatt ggaggagtgg ctattgatgt ggtgaaagta gaagtccctg 13980
cgacgggccg aacactcgtg ctggcttttg taaaaacgtg cgcagtactg gcagcggtgc 14040
acgggctgta catcctgcac gaggttgacc tgacgaccgc gcacaaggaa gcagagtggg 14100
aatttgagcc cctcgcctgg cgggtttggc tggtggtctt ctacttcggc tgcttgtcct 14160
tgaccgtctg gctgctcgag gggagttacg gtggatcgga ccaccacgcc gcgcgagccc 14220
aaagtccaga tgtccgcgcg cggcggtcgg agcttgatga caacatcgcg cagatgggag 14280
ctgtccatgg tctggagctc ccgcggcgtc aggtcaggcg ggagctcctg caggtttacc 14340
tcgcatagac gggtcagggc gcgggctaga tccaggtgat acctaatttc caggggctgg 14400
ttggtggcgg cgtcgatggc ttgcaagagg ccgcatcccc gcggcgcgac tacggtaccg 14460
cgcggcgggc ggtgggccgc gggggtgtcc ttggatgatg catctaaaag cggtgacgcg 14520
ggcgagcccc cggaggtagg gggggctccg gacccgccgg gagagggggc aggggcacgt 14580
cggcgccgcg cgcgggcagg agctggtgct gcgcgcgtag gttgctggcg aacgcgacga 14640
cgcggcggtt gatctcctga atctggcgcc tctgcgtgaa gacgacgggc ccggtgagct 14700
tgagcctgaa agagagttcg acagaatcaa tttcggtgtc gttgacggcg gcctggcgca 14760
aaatctcctg cacgtctcct gagttgtctt gataggcgat ctcggccatg aactgctcga 14820
tctcttcctc ctggagatct ccgcgtccgg ctcgctccac ggtggcggcg aggtcgttgg 14880
aaatgcgggc catgagctgc gagaaggcgt tgaggcctcc ctcgttccag acgcggctgt 14940
agaccacgcc cccttcggca tcgcgggcgc gcatgaccac ctgcgcgaga ttgagctcca 15000
cgtgccgggc gaagacggcg tagtttcgca ggcgctgaaa gaggtagttg agggtggtgg 15060
cggtgtgttc tgccacgaag aagtacataa cccagcgtcg caacgtggat tcgttgatat 15120
cccccaaggc ctcaaggcgc tccatggcct cgtagaagtc cacggcgaag ttgaaaaact 15180
gggagttgcg cgccgacacg gttaactcct cctccagaag acggatgagc tcggcgacag 15240
tgtcgcgcac ctcgcgctca aaggctacag gggcctcttc ttcttcttca atctcctctt 15300
ccataagggc ctccccttct tcttcttctg gcggcggtgg gggagggggg acacggcggc 15360
gacgacggcg caccgggagg cggtcgacaa agcgctcgat catctccccg cggcgacggc 15420
gcatggtctc ggtgacggcg cggccgttct cgcgggggcg cagttggaag acgccgcccg 15480
tcatgtcccg gttatgggtt ggcggggggc tgccatgcgg cagggatacg gcgctaacga 15540
tgcatctcaa caattgttgt gtaggtactc cgccgccgag ggacctgagc gagtccgcat 15600
cgaccggatc ggaaaacctc tcgagaaagg cgtctaacca gtcacagtcg caaggtaggc 15660
tgagcaccgt ggcgggcggc agcgggcggc ggtcggggtt gtttctggcg gaggtgctgc 15720
tgatgatgta attaaagtag gcggtcttga gacggcggat ggtcgacaga agcaccatgt 15780
ccttgggtcc ggcctgctga atgcgcaggc ggtcggccat gccccaggct tcgttttgac 15840
atcggcgcag gtctttgtag tagtcttgca tgagcctttc taccggcact tcttcttctc 15900
cttcctcttg tcctgcatct cttgcatcta tcgctgcggc ggcggcggag tttggccgta 15960
ggtggcgccc tcttcctccc atgcgtgtga ccccgaagcc cctcatcggc tgaagcaggg 16020
ctaggtcggc gacaacgcgc tcggctaata tggcctgctg cacctgcgtg agggtagact 16080
ggaagtcatc catgtccaca aagcggtggt atgcgcccgt gttgatggtg taagtgcagt 16140
tggccataac ggaccagtta acggtctggt gacccggctg cgagagctcg gtgtacctga 16200
gacgcgagta agccctcgag tcaaatacgt agtcgttgca agtccgcacc aggtactggt 16260
atcccaccaa aaagtgcggc ggcggctggc ggtagagggg ccagcgtagg gtggccgggg 16320
ctccgggggc gagatcttcc aacataaggc gatgatatcc gtagatgtac ctggacatcc 16380
aggtgatgcc ggcggcggtg gtggaggcgc gcggaaagtc gcggacgcgg ttccagatgt 16440
tgcgcagcgg caaaaagtgc tccatggtcg ggacgctctg gccggtcagg cgcgcgcaat 16500
cgttgacgct ctagaccgtg caaaaggaga gcctgtaagc gggcactctt ccgtggtctg 16560
gtggataaat tcgcaagggt atcatggcgg acgaccgggg ttcgagcccc gtatccggcc 16620
gtccgccgtg atccatgcgg ttaccgcccg cgtgtcgaac ccaggtgtgc gacgtcagac 16680
aacgggggag tgctcctttt ggcttccttc caggcgcggc ggctgctgcg ctagcttttt 16740
tggccactgg ccgcgcgcag cgtaagcggt taggctggaa agcgaaagca ttaagtggct 16800
cgctccctgt agccggaggg ttattttcca agggttgagt cgcgggaccc ccggttcgag 16860
tctcggaccg gccggactgc ggcgaacggg ggtttgcctc cccgtcatgc aagaccccgc 16920
ttgcaaattc ctccggaaac agggacgagc cccttttttg cttttcccag atgcatccgg 16980
tgctgcggca gatgcgcccc cctcctcagc agcggcaaga gcaagagcag cggcagacat 17040
gcagggcacc ctcccctcct cctaccgcgt caggaggggc gacatccgcg gttgacgcgg 17100
cagcagatgg tgattacgaa cccccgcggc gccgggcccg gcactacctg gacttggagg 17160
agggcgaggg cctggcgcgg ctaggagcgc cctctcctga gcggtaccca agggtgcagc 17220
tgaagcgtga tacgcgtgag gcgtacgtgc cgcggcagaa cctgtttcgc gaccgcgagg 17280
gagaggagcc cgaggagatg cgggatcgaa agttccacgc agggcgcgag ctgcggcatg 17340
gcctgaatcg cgagcggttg ctgcgcgagg aggactttga gcccgacgcg cgaaccggga 17400
ttagtcccgc gcgcgcacac gtggcggccg ccgacctggt aaccgcatac gagcagacgg 17460
tgaaccagga gattaacttt caaaaaagct ttaacaacca cgtgcgtacg cttgtggcgc 17520
gcgaggaggt ggctatagga ctgatgcatc tgtgggactt tgtaagcgcg ctggagcaaa 17580
acccaaatag caagccgctc atggcgcagc tgttccttat agtgcagcac agcagggaca 17640
acgaggcatt cagggatgcg ctgctaaaca tagtagagcc cgagggccgc tggctgctcg 17700
atttgataaa catcctgcag agcatagtgg tgcaggagcg cagcttgagc ctggctgaca 17760
aggtggccgc catcaactat tccatgctta gcctgggcaa gttttacgcc cgcaagatat 17820
accatacccc ttacgttccc atagacaagg aggtaaagat cgaggggttc tacatgcgca 17880
tggcgctgaa ggtgcttacc ttgagcgacg acctgggcgt ttatcgcaac gagcgcatcc 17940
acaaggccgt gagcgtgagc cggcggcgcg agctcagcga ccgcgagctg atgcacagcc 18000
tgcaaagggc cctggctggc acgggcagcg gcgatagaga ggccgagtcc tactttgacg 18060
cgggcgctga cctgcgctgg gccccaagcc gacgcgccct ggaggcagct ggggccggac 18120
ctgggctggc ggtggcaccc gcgcgcgctg gcaacgtcgg cggcgtggag gaatatgacg 18180
aggacgatga gtacgagcca gaggacggcg agtactaagc ggtgatgttt ctgatcagat 18240
gatgcaagac gcaacggacc cggcggtgcg ggcggcgctg cagagccagc cgtccggcct 18300
taactccacg gacgactggc gccaggtcat ggaccgcatc atgtcgctga ctgcgcgcaa 18360
tcctgacgcg ttccggcagc agccgcaggc caaccggctc tccgcaattc tggaagcggt 18420
ggtcccggcg cgcgcaaacc ccacgcacga gaaggtgctg gcgatcgtaa acgcgctggc 18480
cgaaaacagg gccatccggc ccgacgaggc cggcctggtc tacgacgcgc tgcttcagcg 18540
cgtggctcgt tacaacagcg gcaacgtgca gaccaacctg gaccggctgg tgggggatgt 18600
gcgcgaggcc gtggcgcagc gtgagcgcgc gcagcagcag ggcaacctgg gctccatggt 18660
tgcactaaac gccttcctga gtacacagcc cgccaacgtg ccgcggggac aggaggacta 18720
caccaacttt gtgagcgcac tgcggctaat ggtgactgag acaccgcaaa gtgaggtgta 18780
ccagtctggg ccagactatt ttttccagac cagtagacaa ggcctgcaga ccgtaaacct 18840
gagccaggct ttcaaaaact tgcaggggct gtggggggtg cgggctccca caggcgaccg 18900
cgcgaccgtg tctagcttgc tgacgcccaa ctcgcgcctg ttgctgctgc taatagcgcc 18960
cttcacggac agtggcagcg tgtcccggga cacataccta ggtcacttgc tgacactgta 19020
ccgcgaggcc ataggtcagg cgcatgtgga cgagcatact ttccaggaga ttacaagtgt 19080
cagccgcgcg ctggggcagg aggacacggg cagcctggag gcaaccctaa actacctgct 19140
gaccaaccgg cggcagaaga tcccctcgtt gcacagttta aacagcgagg aggagcgcat 19200
tttgcgctac gtgcagcaga gcgtgagcct taacctgatg cgcgacgggg taacgcccag 19260
cgtggcgctg gacatgaccg cgcgcaacat ggaaccgggc atgtatgcct caaaccggcc 19320
gtttatcaac cgcctaatgg actacttgca tcgcgcggcc gccgtgaacc ccgagtattt 19380
caccaatgcc atcttgaacc cgcactggct accgccccct ggtttctaca ccgggggatt 19440
cgaggtgccc gagggtaacg atggattcct ctgggacgac atagacgaca gcgtgttttc 19500
cccgcaaccg cagaccctgc tagagttgca acagcgcgag caggcagagg cggcgctgcg 19560
aaaggaaagc ttccgcaggc caagcagctt gtccgatcta ggcgctgcgg ccccgcggtc 19620
agatgctagt agcccatttc caagcttgat agggtctctt accagcactc gcaccacccg 19680
cccgcgcctg ctgggcgagg aggagtacct aaacaactcg ctgctgcagc cgcagcgcga 19740
aaaaaacctg cctccggcat ttcccaacaa cgggatagag agcctagtgg acaagatgag 19800
tagatggaag acgtacgcgc aggagcacag ggacgtgcca ggcccgcgcc cgcccacccg 19860
tcgtcaaagg cacgaccgtc agcggggtct ggtgtgggag gacgatgact cggcagacga 19920
cagcagcgtc ctggatttgg gagggagtgg caacccgttt gcgcaccttc gccccaggct 19980
ggggagaatg ttttaaaaaa aaaaaagcat gatgcaaaat aaaaaactca ccaaggccat 20040
ggcaccgagc gttggttttc ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag 20100
gaaggtcctc ctccctccta cgagagtgtg gtgagcgcgg cgccagtggc ggcggcgctg 20160
ggttctccct tcgatgctcc cctggacccg ccgtttgtgc ctccgcggta cctgcggcct 20220
accgggggga gaaacagcat ccgttactct gagttggcac ccctattcga caccacccgt 20280
gtgtacctgg tggacaacaa gtcaacggat gtggcatccc tgaactacca gaacgaccac 20340
agcaactttc tgaccacggt cattcaaaac aatgactaca gcccggggga ggcaagcaca 20400
cagaccatca atcttgacga ccggtcgcac tggggcggcg acctgaaaac catcctgcat 20460
accaacatgc caaatgtgaa cgagttcatg tttaccaata agtttaaggc gcgggtgatg 20520
gtgtcgcgct tgcctactaa ggacaatcag gtggagctga aatacgagtg ggtggagttc 20580
acgctgcccg agggcaacta ctccgagacc atgaccatag accttatgaa caacgcgatc 20640
gtggagcact acttgaaagt gggcagacag aacggggttc tggaaagcga catcggggta 20700
aagtttgaca cccgcaactt cagactgggg tttgaccccg tcactggtct tgtcatgcct 20760
ggggtatata caaacgaagc cttccatcca gacatcattt tgctgccagg atgcggggtg 20820
gacttcaccc acagccgcct gagcaacttg ttgggcatcc gcaagcggca acccttccag 20880
gagggcttta ggatcaccta cgatgatctg gagggtggta acattcccgc actgttggat 20940
gtggacgcct accaggcgag cttgaaagat gacaccgaac agggcggggg tggcgcaggc 21000
ggcagcaaca gcagtggcag cggcgcggaa gagaactcca acgcggcagc cgcggcaatg 21060
cagccggtgg aggacatgaa cgatcatgcc attcgcggcg acacctttgc cacacgggct 21120
gaggagaagc gcgctgaggc cgaagcagcg gccgaagctg ccgcccccgc tgcgcaaccc 21180
gaggtcgaga agcctcagaa gaaaccggtg atcaaacccc tgacagagga cagcaagaaa 21240
cgcagttaca acctaataag caatgacagc accttcaccc agtaccgcag ctggtacctt 21300
gcatacaact acggcgaccc tcagaccgga atccgctcat ggaccctgct ttgcactcct 21360
gacgtaacct gcggctcgga gcaggtctac tggtcgttgc cagacatgat gcaagacccc 21420
gtgaccttcc gctccacgcg ccagatcagc aactttccgg tggtgggcgc cgagctgttg 21480
cccgtgcact ccaagagctt ctacaacgac caggccgtct actcccaact catccgccag 21540
tttacctctc tgacccacgt gttcaatcgc tttcccgaga accagatttt ggcgcgcccg 21600
ccagccccca ccatcaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg 21660
ctaccgctgc gcaacagcat cggaggagtc cagcgagtga ccattactga cgccagacgc 21720
cgcacctgcc cctacgttta caaggccctg ggcatagtct cgccgcgcgt cctatcgagc 21780
cgcacttttt gagcaagcat gtccatcctt atatcgccca gcaataacac aggctggggc 21840
ctgcgcttcc caagcaagat gtttggcggg gccaagaagc gctccgacca acacccagtg 21900
cgcgtgcgcg ggcactaccg cgcgccctgg ggcgcgcaca aacgcggccg cactgggcgc 21960
accaccgtcg atgacgccat cgacgcggtg gtggaggagg cgcgcaacta cacgcccacg 22020
ccgccaccag tgtccacagt ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc 22080
tatgctaaaa tgaagagacg gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc 22140
actgccgccc aacgcgcggc ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg 22200
gcggccatgc gggccgctcg aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc 22260
aggcgacgag cggccgccgc agcagccgcg gccattagtg ctatgactca gggtcgcagg 22320
ggcaacgtgt attgggtgcg cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc 22380
cccccgcgca actagattgc aagaaaaaac tacttagact cgtactgttg tatgtatcca 22440
gcggcggcgg cgcgcaacga agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag 22500
gtcatcgcgc cggagatcta tggccccccg aagaaggaag agcaggatta caagccccga 22560
aagctaaagc gggtcaaaaa gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg 22620
gaactgctgc acgctaccgc gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa 22680
cgtgttttgc gacccggcac caccgtagtc tttacgcccg gtgagcgctc cacccgcacc 22740
tacaagcgcg tgtatgatga ggtgtacggc gacgaggacc tgcttgagca ggccaacgag 22800
cgcctcgggg agtttgccta cggaaagcgg cataaggaca tgctggcgtt gccgctggac 22860
gagggcaacc caacacctag cctaaagccc gtaacactgc agcaggtgct gcccgcgctt 22920
gcaccgtccg aagaaaagcg cggcctaaag cgcgagtctg gtgacttggc acccaccgtg 22980
cagctgatgg tacccaagcg ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa 23040
cctgggctgg agcccgaggt ccgcgtgcgg ccaatcaagc aggtggcgcc gggactgggc 23100
gtgcagaccg tggacgttca gatacccact accagtagca ccagtattgc caccgccaca 23160
gagggcatgg agacacaaac gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag 23220
gcggtcgctg cggccgcgtc caagacctct acggaggtgc aaacggaccc gtggatgttt 23280
cgcgtttcag ccccccggcg cccgcgcggt tcgaggaagt acggcgccgc cagcgcgcta 23340
ctgcccgaat atgccctaca tccttccatt gcgcctaccc ccggctatcg tggctacacc 23400
taccgcccca gaagacgagc aactacccga cgccgaacca ccactggaac ccgccgccgc 23460
cgtcgccgtc gccagcccgt gctggccccg atttccgtgc gcagggtggc tcgcgaagga 23520
ggcaggaccc tggtgctgcc aacagcgcgc taccacccca gcatcgttta aaagccggtc 23580
tttgtggttc ttgcagatat ggccctcacc tgccgcctcc gtttcccggt gccgggattc 23640
cgaggaagaa tgcaccgtag gaggggcatg gccggccacg gcctgacggg cggcatgcgt 23700
cgtgcgcacc accggcggcg gcgcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc 23760
ctccttattc cactgatcgc cgcggcgatt ggcgccgtgc ccggaattgc atccgtggcc 23820
ttgcaggcgc agagacactg attaaaaaca agttgcatgt ggaaaaatca aaataaaaag 23880
tctggactct cacgctcgct tggtcctgta actattttgt agaatggaag acatcaactt 23940
tgcgtctctg gccccgcgac acggctcgcg cccgttcatg ggaaactggc aagatatcgg 24000
caccagcaat atgagcggtg gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa 24060
tttcggttcc accgttaaga actatggcag caaggcctgg aacagcagca caggccagat 24120
gctgagggat aagttgaaag agcaaaattt ccaacaaaag gtggtagatg gcctggcctc 24180
tggcattagc ggggtggtgg acctggccaa ccaggcagtg caaaataaga ttaacagtaa 24240
gcttgatccc cgccctcccg tagaggagcc tccaccggcc gtggagacag tgtctccaga 24300
ggggcgtggc gaaaagcgtc cgcgccccga cagggaagaa actctggtga cgcaaataga 24360
cgagcctccc tcgtacgagg aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc 24420
gcccatggct accggagtgc tgggccagca cacacccgta acgctggacc tgcctccccc 24480
cgccgacacc cagcagaaac ctgtgctgcc aggcccgacc gccgttgttg taacccgtcc 24540
tagccgcgcg tccctgcgcc gcgccgccag cggtccgcga tcgttgcggc ccgtagccag 24600
tggcaactgg caaagcacac tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg 24660
ccgacgatgc ttctgaatag ctaacgtgtc gtatgtgtgt catgtatgcg tccatgtcgc 24720
cgccagagga gctgctgagc cgccgcgcgc ccgctttcca agatggctac cccttcgatg 24780
atgccgcagt ggtcttacat gcacatctcg ggccaggacg cctcggagta cctgagcccc 24840
gggctggtgc agtttgcccg cgccaccgag acgtacttca gcctgaataa caagtttaga 24900
aaccccacgg tggcgcctac gcacgacgtg accacagacc ggtcccagcg tttgacgctg 24960
cggttcatcc ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg gttcacccta 25020
gctgtgggtg ataaccgtgt gctggacatg gcttccacgt actttgacat ccgcggcgtg 25080
ctggacaggg gccctacttt taagccctac tctggcactg cctacaacgc cctggctccc 25140
aagggtgccc caaatccttg cgaatgggat gaagctgcta ctgctcttga aataaaccta 25200
gaagaagagg acgatgacaa cgaagacgaa gtagacgagc aagctgagca gcaaaaaact 25260
cacgtatttg ggcaggcgcc ttattctggt ataaatatta caaaggaggg tattcaaata 25320
ggtgtcgaag gtcaaacacc taaatatgcc gataaaacat ttcaacctga acctcaaata 25380
ggagaatctc agtggtacga aactgaaatt aatcatgcag ctgggagagt ccttaaaaag 25440
actaccccaa tgaaaccatg ttacggttca tatgcaaaac ccacaaatga aaatggaggg 25500
caaggcattc ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga aatgcaattt 25560
ttctcaacta ctgaggcgac cgcaggcaat ggtgataact tgactcctaa agtggtattg 25620
tacagtgaag atgtagatat agaaacccca gacactcata tttcttacat gcccactatt 25680
aaggaaggta actcacgaga actaatgggc caacaatcta tgcccaacag gcctaattac 25740
attgctttta gggacaattt tattggtcta atgtattaca acagcacggg taatatgggt 25800
gttctggcgg gccaagcatc gcagttgaat gctgttgtag atttgcaaga cagaaacaca 25860
gagctttcat accagctttt gcttgattcc attggtgata gaaccaggta cttttctatg 25920
tggaatcagg ctgttgacag ctatgatcca gatgttagaa ttattgaaaa tcatggaact 25980
gaagatgaac ttccaaatta ctgctttcca ctgggaggtg tgattaatac agagactctt 26040
accaaggtaa aacctaaaac aggtcaggaa aatggatggg aaaaagatgc tacagaattt 26100
tcagataaaa atgaaataag agttggaaat aattttgcca tggaaatcaa tctaaatgcc 26160
aacctgtgga gaaatttcct gtactccaac atagcgctgt atttgcccga caagctaaag 26220
tacagtcctt ccaacgtaaa aatttctgat aacccaaaca cctacgacta catgaacaag 26280
cgagtggtgg ctcccgggtt agtggactgc tacattaacc ttggagcacg ctggtccctt 26340
gactatatgg acaacgtcaa cccatttaac caccaccgca atgctggcct gcgctaccgc 26400
tcaatgttgc tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc tcagaagttc 26460
tttgccatta aaaacctcct tctcctgccg ggctcataca cctacgagtg gaacttcagg 26520
aaggatgtta acatggttct gcagagctcc ctaggaaatg acctaagggt tgacggagcc 26580
agcattaagt ttgatagcat ttgcctttac gccaccttct tccccatggc ccacaacacc 26640
gcctccacgc ttgaggccat gcttagaaac gacaccaacg accagtcctt taacgactat 26700
ctctccgccg ccaacatgct ctaccctata cccgccaacg ctaccaacgt gcccatatcc 26760
atcccctccc gcaactgggc ggctttccgc ggctgggcct tcacgcgcct taagactaag 26820
gaaaccccat cactgggctc gggctacgac ccttattaca cctactctgg ctctataccc 26880
tacctagatg gaacctttta cctcaaccac acctttaaga aggtggccat tacctttgac 26940
tcttctgtca gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag 27000
cgctcagttg acggggaggg ttacaacgtt gcccagtgta acatgaccaa agactggttc 27060
ctggtacaaa tgctagctaa ctacaacatt ggctaccagg gcttctatat cccagagagc 27120
tacaaggacc gcatgtactc cttctttaga aacttccagc ccatgagccg tcaggtggtg 27180
gatgatacta aatacaagga ctaccaacag gtgggcatcc tacaccaaca caacaactct 27240
ggatttgttg gctaccttgc ccccaccatg cgcgaaggac aggcctaccc tgctaacttc 27300
ccctatccgc ttataggcaa gaccgcagtt gacagcatta cccagaaaaa gtttctttgc 27360
gatcgcaccc tttggcgcat cccattctcc agtaacttta tgtccatggg cgcactcaca 27420
gacctgggcc aaaaccttct ctacgccaac tccgcccacg cgctagacat gacttttgag 27480
gtggatccca tggacgagcc cacccttctt tatgttttgt ttgaagtctt tgacgtggtc 27540
cgtgtgcacc ggccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg 27600
gccggcaacg ccacaacata aagaagcaag caacatcaac aacagctgcc gccatgggct 27660
ccagtgagca ggaactgaaa gccattgtca aagatcttgg ttgtgggcca tattttttgg 27720
gcacctatga caagcgcttt ccaggctttg tttctccaca caagctcgcc tgcgccatag 27780
tcaatacggc cggtcgcgag actgggggcg tacactggat ggcctttgcc tggaacccgc 27840
actcaaaaac atgctacctc tttgagccct ttggcttttc tgaccagcga ctcaagcagg 27900
tttaccagtt tgagtacgag tcactcctgc gccgtagcgc cattgcttct tcccccgacc 27960
gctgtataac gctggaaaag tccacccaaa gcgtacaggg gcccaactcg gccgcctgtg 28020
gactattctg ctgcatgttt ctccacgcct ttgccaactg gccccaaact cccatggatc 28080
acaaccccac catgaacctt attaccgggg tacccaactc catgctcaac agtccccagg 28140
tacagcccac cctgcgtcgc aaccaggaac agctctacag cttcctggag cgccactcgc 28200
cctacttccg cagccacagt gcgcagatta ggagcgccac ttctttttgt cacttgaaaa 28260
acatgtaaaa ataatgtact agagacactt tcaataaagg caaatgcttt tatttgtaca 28320
ctctcgggtg attatttacc cccacccttg ccgtctgcgc cgtttaaaaa tcaaaggggt 28380
tctgccgcgc atcgctatgc gccactggca gggacacgtt gcgatactgg tgtttagtgc 28440
tccacttaaa ctcaggcaca accatccgcg gcagctcggt gaagttttca ctccacaggc 28500
tgcgcaccat caccaacgcg tttagcaggt cgggcgccga tatcttgaag tcgcagttgg 28560
ggcctccgcc ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg aacactatca 28620
gcgccgggtg gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc gcgtccaggt 28680
cctccgcgtt gctcagggcg aacggagtca actttggtag ctgccttccc aaaaagggcg 28740
cgtgcccagg ctttgagttg cactcgcacc gtagtggcat caaaaggtga ccgtgcccgg 28800
tctgggcgtt aggatacagc gcctgcataa aagccttgat ctgcttaaaa gccacctgag 28860
cctttgcgcc ttcagagaag aacatgccgc aagacttgcc ggaaaactga ttggccggac 28920
aggccgcgtc gtgcacgcag caccttgcgt cggtgttgga gatctgcacc acatttcggc 28980
cccaccggtt cttcacgatc ttggccttgc tagactgctc cttcagcgcg cgctgcccgt 29040
tttcgctcgt cacatccatt tcaatcacgt gctccttatt tatcataatg cttccgtgta 29100
gacacttaag ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg cagcccgtgg 29160
gctcgtgatg cttgtaggtc acctctgcaa acgactgcag gtacgcctgc aggaatcgcc 29220
ccatcatcgt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg cggtgctcct 29280
cgttcagcca ggtcttgcat acggccgcca gagcttccac ttggtcaggc agtagtttga 29340
agttcgcctt tagatcgtta tccacgtggt acttgtccat cagcgcgcgc gcagcctcca 29400
tgcccttctc ccacgcagac acgatcggca cactcagcgg gttcatcacc gtaatttcac 29460
tttccgcttc gctgggctct tcctcttcct cttgcgtccg cataccacgc gccactgggt 29520
cgtcttcatt cagccgccgc actgtgcgct tacctccttt gccatgcttg attagcaccg 29580
gtgggttgct gaaacccacc atttgtagcg ccacatcttc tctttcttcc tcgctgtcca 29640
cgattacctc tggtgatggc gggcgctcgg gcttgggaga agggcgcttc tttttcttct 29700
tgggcgcaat ggccaaatcc gccgccgagg tcgatggccg cgggctgggt gtgcgcggca 29760
ccagcgcgtc ttgtgatgag tcttcctcgt cctcggactc gatacgccgc ctcatccgct 29820
tttttggggg cgcccgggga ggcggcggcg acggggacgg ggacgacacg tcctccatgg 29880
ttgggggacg tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc tgctcctctt 29940
cccgactggc catttccttc tcctataggc agaaaaagat catggagtca gtcgagaaga 30000
aggacagcct aaccgccccc tctgagttcg ccaccaccgc ctccaccgat gccgccaacg 30060
cgcctaccac cttccccgtc gaggcacccc cgcttgagga ggaggaagtg attatcgagc 30120
aggacccagg ttttgtaagc gaagacgacg aggaccgctc agtaccaaca gaggataaaa 30180
agcaagacca ggacaacgca gaggcaaacg aggaacaagt cgggcggggg gacgaaaggc 30240
atggcgacta cctagatgtg ggagacgacg tgctgttgaa gcatctgcag cgccagtgcg 30300
ccattatctg cgacgcgttg caagagcgca gcgatgtgcc cctcgccata gcggatgtca 30360
gccttgccta cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc caagaaaacg 30420
gcacatgcga gcccaacccg cgcctcaact tctaccccgt atttgccgtg ccagaggtgc 30480
ttgccaccta tcacatcttt ttccaaaact gcaagatacc cctatcctgc cgtgccaacc 30540
gcagccgagc ggacaagcag ctggccttgc ggcagggcgc tgtcatacct gatatcgcct 30600
cgctcaacga agtgccaaaa atctttgagg gtcttggacg cgacgagaag cgcgcggcaa 30660
acgctctgca acaggaaaac agcgaaaatg aaagtcactc tggagtgttg gtggaactcg 30720
agggtgacaa cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc cactttgcct 30780
acccggcact taacctaccc cccaaggtca tgagcacagt catgagtgag ctgatcgtgc 30840
gccgtgcgca gcccctggag agggatgcaa atttgcaaga acaaacagag gagggcctac 30900
ccgcagttgg cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct gccgacttgg 30960
aggagcgacg caaactaatg atggccgcag tgctcgttac cgtggagctt gagtgcatgc 31020
agcggttctt tgctgacccg gagatgcagc gcaagctaga ggaaacattg cactacacct 31080
ttcgacaggg ctacgtacgc caggcctgca agatctccaa cgtggagctc tgcaacctgg 31140
tctcctacct tggaattttg cacgaaaacc gccttgggca aaacgtgctt cattccacgc 31200
tcaagggcga ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt ctatgctaca 31260
cctggcagac ggccatgggc gtttggcagc agtgcttgga ggagtgcaac ctcaaggagc 31320
tgcagaaact gctaaagcaa aacttgaagg acctatggac ggccttcaac gagcgctccg 31380
tggccgcgca cctggcggac atcattttcc ccgaacgcct gcttaaaacc ctgcaacagg 31440
gtctgccaga cttcaccagt caaagcatgt tgcagaactt taggaacttt atcctagagc 31500
gctcaggaat cttgcccgcc acctgctgtg cacttcctag cgactttgtg cccattaagt 31560
accgcgaatg ccctccgccg ctttggggcc actgctacct tctgcagcta gccaactacc 31620
ttgcctacca ctctgacata atggaagacg tgagcggtga cggtctactg gagtgtcact 31680
gtcgctgcaa cctatgcacc ccgcaccgct ccctggtttg caattcgcag ctgcttaacg 31740
aaagtcaaat tatcggtacc tttgagctgc agggtccctc gcctgacgaa aagtccgcgg 31800
ctccggggtt gaaactcact ccggggctgt ggacgtcggc ttaccttcgc aaatttgtac 31860
ctgaggacta ccacgcccac gagattaggt tctacgaaga ccaatcccgc ccgccaaatg 31920
cggagcttac cgcctgcgtc attacccagg gccacattct tggccaattg caagccatca 31980
acaaagcccg ccaagagttt ctgctacgaa agggacgggg ggtttacttg gacccccagt 32040
ccggcgagga gctcaaccca atccccccgc cgccgcagcc ctatcagcag cagccgcggg 32100
cccttgcttc ccaggatggc acccaaaaag aagctgcagc tgccgccgcc acccacggac 32160
gaggaggaat actgggacag tcaggcagag gaggttttgg acgaggagga ggaggacatg 32220
atggaagact gggagagcct agacgaggaa gcttccgagg tcgaagaggt gtcagacgaa 32280
acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaatcggc aaccggttcc 32340
agcatggcta caacctccgc tcctcaggcg ccgccggcac tgcccgttcg ccgacccaac 32400
cgtagatggg acaccactgg aaccagggcc ggtaagtcca agcagccgcc gccgttagcc 32460
caagagcaac aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa cgccatagtt 32520
gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct tctctaccat 32580
cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta cagcccatac 32640
tgcaccggcg gcagcggcag cggcagcaac agcagcggcc acacagaagc aaaggcgacc 32700
ggatagcaag actctgacaa agcccaagaa atccacagcg gcggcagcag caggaggagg 32760
agcgctgcgt ctggcgccca acgaacccgt atcgacccgc gagcttagaa acaggatttt 32820
tcccactctg tatgctatat ttcaacagag caggggccaa gaacaagagc tgaaaataaa 32880
aaacaggtct ctgcgatccc tcacccgcag ctgcctgtat cacaaaagcg aagatcagct 32940
tcggcgcacg ctggaagacg cggaggctct cttcagtaaa tactgcgcgc tgactcttaa 33000
ggactagttt cgcgcccttt ctcaaattta agcgcgaaaa ctacgtcatc tccagcggcc 33060
acacccggcg ccagcacctg tcgtcagcgc cattatgagc aaggaaattc ccacgcccta 33120
catgtggagt taccagccac aaatgggact tgcggctgga gctgcccaag actactcaac 33180
ccgaataaac tacatgagcg cgggacccca catgatatcc cgggtcaacg gaatccgcgc 33240
ccaccgaaac cgaattctct tggaacaggc ggctattacc accacacctc gtaataacct 33300
taatccccgt agttggcccg ctgccctggt gtaccaggaa agtcccgctc ccaccactgt 33360
ggtacttccc agagacgccc aggccgaagt tcagatgact aactcagggg cgcagcttgc 33420
gggcggcttt cgtcacaggg tgcggtcgcc cgggcagggt ataactcacc tgacaatcag 33480
agggcgaggt attcagctca acgacgagtc ggtgagctcc tcgcttggtc tccgtccgga 33540
cgggacattt cagatcggcg gcgccggccg tccttcattc acgcctcgtc aggcaatcct 33600
aactctgcag acctcgtcct ctgagccgcg ctctggaggc attggaactc tgcaatttat 33660
tgaggagttt gtgccatcgg tctactttaa ccccttctcg ggacctcccg gccactatcc 33720
ggatcaattt attcctaact ttgacgcggt aaaggactcg gcggacggct acgactgaat 33780
gttaagtgga gaggcagagc aactgcgcct gaaacacctg gtccactgtc gccgccacaa 33840
gtgctttgcc cgcgactccg gtgagttttg ctactttgaa ttgcccgagg atcatatcga 33900
gggcccggcg cacggcgtcc ggcttaccgc ccagggagag cttgcccgta gcctgattcg 33960
ggagtttacc cagcgccccc tgctagttga gcgggacagg ggaccctgtg ttctcactgt 34020
gatttgcaac tgtcctaacc ttggattaca tcaagatctt tgttgccatc tctgtgctga 34080
gtataataaa tacagaaatt aaaatatact ggggctccta tcgccatcct gtaaacgcca 34140
ccgtcttcac ccgcccaagc aaaccaaggc gaaccttacc tggtactttt aacatctctc 34200
cctctgtgat ttacaacagt ttcaacccag acggagtgag tctacgagag aacctctccg 34260
agctcagcta ctccatcaga aaaaacacca ccctccttac ctgccgggaa cgtacgagtg 34320
cgtcaccggc cgctgcacca cacctaccgc ctgaccgtaa accagacttt ttccggacag 34380
acctcaataa ctctgtttac cagaacagga ggtgagctta gaaaaccctt agggtattag 34440
gccaaaggcg cagctactgt ggggtttatg aacaattcaa gcaactctac gggctattct 34500
aattcaggtt tctctagaaa tggacggaat tattacagag cagcgcctgc tagaaagacg 34560
cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg ttaacttgca 34620
ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct acgacagtaa 34680
taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat tggtggtcat 34740
ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag gctgcattca 34800
ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt gcggtctcaa 34860
agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac ttaaaatcag 34920
ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc cagctctggt 34980
attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg tcagtttcct 35040
cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag cgcgcaagac 35100
cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt cctccaactg 35160
tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt ccccctgggg 35220
tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt gcgctcaaaa 35280
tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat gtaaccactg 35340
tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct gcacccctca 35400
cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc gcgggcaaca 35460
cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt agcattgcca 35520
cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca ggccccctca 35580
ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact actgccactg 35640
gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa ctaggactaa 35700
agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta gcaactggtc 35760
caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc ttgggttttg 35820
attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat tctcaaaaca 35880
gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta aatctaagac 35940
taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac tacaacaaag 36000
gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg 36060
ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat gggcttgaat 36120
ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc catggcctag 36180
aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt tttgacagca 36240
caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg accacaccag 36300
ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact ttggtcttaa 36360
caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa ggcagtttgg 36420
ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac gaaaatggag 36480
tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat ggagatctta 36540
ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca gcttatccaa 36600
aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta aacggagaca 36660
aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca ggagacacaa 36720
ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac tacattaatg 36780
aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa agaatcgttt 36840
gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca tttttcattc 36900
agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa tcaaactcac 36960
agaaccctag tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct 37020
ccccggctgg ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata 37080
ttccacacgg tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc 37140
agctcactta agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc 37200
ggttgcttaa cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg 37260
tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc 37320
tccgtcctgc aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc 37380
agcataaggc gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca 37440
cagtaactgc agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat 37500
ccaaagctca tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag 37560
attaagtggc gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg 37620
taattcacca cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc 37680
atcctaaacc agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg 37740
gaacaatgac agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata 37800
tcaatgttgg cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc 37860
cgcgttagaa ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg 37920
cagggaagac ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc 37980
agcggatgat cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc 38040
ctactgtacg gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat 38100
ggaacgccgg acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga 38160
tctgcgtctc cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc 38220
tctcaaagca tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc 38280
tgccctgata acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt 38340
ctgcgagtca cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt 38400
ccaaaagatt atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg 38460
tggcgtggtc aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa 38520
tggcttccaa aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag 38580
ggtgaatctc ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc 38640
gccaccttct caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa 38700
tctgctccag agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc 38760
aggttcctca cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc 38820
ccgtaggtcc cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc 38880
ggccacttcc ccgccaggaa ccttgacaaa agaacccaca ctgattatga cacgcatact 38940
cggagctatg ctaaccagcg tagccccgat gtaagctttg ttgcatgggc ggcgatataa 39000
aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 39060
agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 39120
tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 39180
catttaaaca ttagaagcct gtcttacaac aggaaaaaca acccttataa gcataagacg 39240
gactacggcc atgccggcgt gaccgtaaaa aaactggtca ccgtgattaa aaagcaccac 39300
cgacagctcc tcggtcatgt ccggagtcat aatgtaagac tcggtaaaca catcaggttg 39360
attcacatcg gtcagtgcta aaaagcgacc gaaatagccc gggggaatac atacccgcag 39420
gcgtagagac aacattacag cccccatagg aggtataaca aaattaatag gagagaaaaa 39480
cacataaaca cctgaaaaac cctcctgcct aggcaaaata gcaccctccc gctccagaac 39540
aacatacagc gcttccacag cggcagccat aacagtcagc cttaccagta aaaaagaaaa 39600
cctattaaaa aaacaccact cgacacggca cataacttcg tatagcatac attatacgaa 39660
gttatcagct caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag 39720
gactaaaaaa tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa 39780
cctacgccca gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt 39840
tcccacgtta cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac 39900
tccgccctaa aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc 39960
caccccctca ttatcatatt ggcttcaatc caaaataagg tatattattg atgatgttaa 40020
ttaagggcgg ccgcacgggc catcgatggg gatccatccg cggagaagct tctcgaccaa 40080
ttctcatgtt tgacagctta tcatcgaatt tctgccattc atccgcttat tatcacttat 40140
tcaggcgtag caaccaggcg tttaagggca ccaataactg ccttaaaaaa aaaatcaatc 40200
taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct 40260
atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata 40320
actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca 40380
cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga 40440
agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga 40500
gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg 40560
gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga 40620
gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt 40680
gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct 40740
cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca 40800
ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaac acgggataat 40860
accgcgccac atagcagaac tttaaaagtg ctcatcattg gagaacgttc ttcggggcga 40920
aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc 40980
aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg 41040
caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc 41100
ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt 41160
gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca 41220
cctgacgtag ttaac 41235
<210> 52
<211> 41236
<212> DNA
<213> 人工序列
<220>
<223> pBAd5-FG40-GFP
<400> 52
taatcagaat tggttaattg gttgtaacac tggcttaatg cctaggcaaa atagcaccct 60
cccgctccag aacaacatac agcgcttcac agcggcagcc taacagtcag ccttaccagt 120
aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa tcagtcacag 180
tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga cgtaacggtt 240
aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa acgaaagcca 300
aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt aacttcccat 360
tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac ctacgtcacc 420
cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta tcatattggc 480
ttcaatccaa aataaggtat attcatcaat aatatacctt attttggatt gaagccaata 540
tgataatgag ggggtggagt ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg 600
tagttagtgt ggcggaagtg tgatgttgca agtgtggcgg aacacatgta agcgacggat 660
gtggcaaaag tgacgttttt ggtgtgcgcc ggtgtacaca ggaagtgaca attttcgcgc 720
ggttttaggc ggatgttgta gtaaatttgg gcgtaaccga gtaagatttg gccattttcg 780
cgggaaaact gaataagagg aagtgaaatc tgaataattt tgtgttactc atagcgcgta 840
ataatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac 900
ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 960
aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 1020
ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac 1080
gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 1140
cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt 1200
gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc 1260
aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 1320
tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg 1380
ggaggtctat ataagcagag ctggtttagt gaaccgtcag atccgctagc gctaccggac 1440
tcagatctcg agctcaagct tcgaattctg cagtcgacgg taccgcgggc ccgggatcca 1500
ccggtcgcca ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg 1560
gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc 1620
gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg 1680
ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc 1740
gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag 1800
cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag 1860
ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac 1920
atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac 1980
aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc 2040
gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg 2100
cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc 2160
gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag 2220
ctgtacaagt aaagcggccg cgactctaga tcataatcag ccataccaca tttgtagagg 2280
ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg 2340
caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca 2400
tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac 2460
tcatcaatgt atcttaaatc gaattcaagc ttgtcgactc gaagatctga gctcacgcgt 2520
gaagttccta ttccgaagtt cctattctct agaaagtata ggaacttcag agcgcttttg 2580
aagctggggt gggcgaagaa ctccagcatg agatccccag agcgcttttg aagctgcgtt 2640
taaacgcgat atcccgggag ctcccgatat cgcgtttaaa cgcagcttgg cgtaatcatg 2700
gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc 2760
cggaagactg aaatgtgtgg gcgtggctta agggtgggaa agaatatata aggtgggggt 2820
cttatgtagt tttgtatctg ttttgcagca gccgccgccg ccatgagcac caactcgttt 2880
gatggaagca ttgtgagctc atatttgaca acgcgcatgc ccccatgggc cggggtgcgt 2940
cagaatgtga tgggctccag cattgatggt cgccccgtcc tgcccgcaaa ctctactacc 3000
ttgacctacg agaccgtgtc tggaacgccg ttggagactg cagcctccgc cgccgcttca 3060
gccgctgcag ccaccgcccg cgggattgtg actgactttg ctttcctgag cccgcttgca 3120
agcagtgcag cttcccgttc atccgcccgc gatgacaagt tgacggctct tttggcacaa 3180
ttggattctt tgacccggga acttaatgtc gtttctcagc agctgttgga tctgcgccag 3240
caggtttctg ccctgaaggc ttcctcccct cccaatgcgg tttaaaacat aaataaaaaa 3300
ccagactctg tttggatttg gatcaagcaa gtgtcttgct gtctttattt aggggttttg 3360
cgcgcgcggt aggcccggga ccagcggtct cggtcgttga gggtcctgtg tattttttcc 3420
aggacgtggt aaaggtgact ctggatgttc agatacatgg gcataagccc gtctctgggg 3480
tggaggtagc accactgcag agcttcatgc tgcggggtgg tgttgtagat gatccagtcg 3540
tagcaggagc gctgggcgtg gtgcctaaaa atgtctttca gtagcaagct gattgccagg 3600
ggcaggccct tggtgtaagt gtttacaaag cggttaagct gggatgggtg catacgtggg 3660
gatatgagat gcatcttgga ctgtattttt aggttggcta tgttcccagc catatccctc 3720
cggggattca tgttgtgcag aaccaccagc acagtgtatc cggtgcactt gggaaatttg 3780
tcatgtagct tagaaggaaa tgcgtggaag aacttggaga cgcccttgtg acctccaaga 3840
ttttccatgc attcgtccat aatgatggca atgggcccac gggcggcggc ctgggcgaag 3900
atatttctgg gatcactaac gtcatagttg tgttccagga tgagatcgtc ataggccatt 3960
tttacaaagc gcgggcggag ggtgccagac tgcggtataa tggttccatc cggcccaggg 4020
gcgtagttac cctcacagat ttgcatttcc cacgctttga gttcagatgg ggggatcatg 4080
tctacctgcg gggcgatgaa gaaaacggtt tccggggtag gggagatcag ctgggaagaa 4140
agcaggttcc tgagcagctg cgacttaccg cagccggtgg gcccgtaaat cacacctatt 4200
accgggtgca actggtagtt aagagagctg cagctgccgt catccctgag caggggggcc 4260
acttcgttaa gcatgtccct gactcgcatg ttttccctga ccaaatccgc cagaaggcgc 4320
tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt ttttcaacgg tttgagaccg 4380
tccgccgtag gcatgctttt gagcgtttga ccaagcagtt ccaggcggtc ccacagctcg 4440
gtcacctgct ctacggcatc tcgatccagc atatctcctc gtttcgcggg ttggggcggc 4500
tttcgctgta cggcagtagt cggtgctcgt ccagacgggc cagggtcatg tctttccacg 4560
ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa ggggtgcgct ccgggctgcg 4620
cgctggccag ggtgcgcttg aggctggtcc tgctggtgct gaagcgctgc cggtcttcgc 4680
cctgcgcgtc ggccaggtag catttgacca tggtgtcata gtccagcccc tccgcggcgt 4740
ggcccttggc gcgcagcttg cccttggagg aggcgccgca cgaggggcag tgcagacttt 4800
tgagggcgta gagcttgggc gcgagaaata ccgattccgg ggagtaggca tccgcgccgc 4860
aggccccgca gacggtctcg cattccacga gccaggtgag ctctggccgt tcggggtcaa 4920
aaaccaggtt tcccccatgc tttttgatgc gtttcttacc tctggtttcc atgagccggt 4980
gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta tacagacttg agaggcctgt 5040
cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc ggaccactct gagacaaagg 5100
ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg gtagcggtcg ttgtccacta 5160
gggggtccac tcgctccagg gtgtgaagac acatgtcgcc ctcttcggca tcaaggaagg 5220
tgattggttt gtaggtgtag gccacgtgac cgggtgttcc tgaagggggg ctataaaagg 5280
gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct gtctgcgagg gccagctgtt 5340
ggggtgagta ctccctctga aaagcgggca tgacttctgc gctaagattg tcagtttcca 5400
aaaacgagga ggatttgata ttcacctggc ccgcggtgat gcctttgagg gtggccgcat 5460
ccatctggtc agaaaagaca atctttttgt tgtcaagctt ggtggcaaac gacccgtaga 5520
gggcgttgga cagcaacttg gcgatggagc gcagggtttg gtttttgtcg cgatcggcgc 5580
gctccttggc cgcgatgttt agctgcacgt attcgcgcgc aacgcaccgc cattcgggaa 5640
agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca accgcggttg tgcagggtga 5700
caaggtcaac gctggtggct acctctccgc gtaggcgctc gttggtccag cagaggcggc 5760
cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg cgtctcgtcc ggggggtctg 5820
cgtccacggt aaagaccccg ggcagcaggc gcgcgtcgaa gtagtctatc ttgcatcctt 5880
gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc gcgctcgtat gggttgagtg 5940
ggggacccca tggcatgggg tgggtgagcg cggaggcgta catgccgcaa atgtcgtaaa 6000
cgtagagggg ctctctgagt attccaagat atgtagggta gcatcttcca ccgcggatgc 6060
tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag gaggtcggga ccgaggttgc 6120
tacgggcggg ctgctctgct cggaagacta tctgcctgaa gatggcatgt gagttggatg 6180
atatggttgg acgctggaag acgttgaagc tggcgtctgt gagacctacc gcgtcacgca 6240
cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc ggcggtgacc tgcacgtcta 6300
gggcgcagta gtccagggtt tccttgatga tgtcatactt atcctgtccc ttttttttcc 6360
acagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcggaaacc 6420
cgtcggcctc cgaacggtaa gagcctagca tgtagaactg gttgacggcc tggtaggcgc 6480
agcatccctt ttctacgggt agcgcgtatg cctgcgcggc cttccggagc gaggtgtggg 6540
tgagcgcaaa ggtgtccctg accatgactt tgaggtactg gtatttgaag tcagtgtcgt 6600
cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt tttggaacgc ggatttggca 6660
gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg aggcataaag ttgcgtgtga 6720
tgcggaaggg tcccggcacc tcggaacggt tgttaattac ctgggcggcg agcacgatct 6780
cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc caagaagcgc gggatgccct 6840
tgatggaagg caatttttta agttcctcgt aggtgagctc ttcaggggag ctgagcccgt 6900
gctctgaaag ggcccagtct gcaagatgag ggttggaagc gacgaatgag ctccacaggt 6960
cacgggccat tagcatttgc aggtggtcgc gaaaggtcct aaactggcga cctatggcca 7020
ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg ttcccagcgg tcccatccaa 7080
ggttcgcggc taggtctcgc gcggcagtca ctagaggctc atctccgccg aacttcatga 7140
ccagcatgaa gggcacgagc tgcttcccaa aggcccccat ccaagtatag gtctctacat 7200
cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc gatcgggaag aactggatct 7260
cccgccacca attggaggag tggctattga tgtggtgaaa gtagaagtcc ctgcgacggg 7320
ccgaacactc gtgctggctt ttgtaaaaac gtgcgcagta ctggcagcgg tgcacgggct 7380
gtacatcctg cacgaggttg acctgacgac cgcgcacaag gaagcagagt gggaatttga 7440
gcccctcgcc tggcgggttt ggctggtggt cttctacttc ggctgcttgt ccttgaccgt 7500
ctggctgctc gaggggagtt acggtggatc ggaccaccac gccgcgcgag cccaaagtcc 7560
agatgtccgc gcgcggcggt cggagcttga tgacaacatc gcgcagatgg gagctgtcca 7620
tggtctggag ctcccgcggc gtcaggtcag gcgggagctc ctgcaggttt acctcgcata 7680
gacgggtcag ggcgcgggct agatccaggt gatacctaat ttccaggggc tggttggtgg 7740
cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc gactacggta ccgcgcggcg 7800
ggcggtgggc cgcgggggtg tccttggatg atgcatctaa aagcggtgac gcgggcgagc 7860
ccccggaggt agggggggct ccggacccgc cgggagaggg ggcaggggca cgtcggcgcc 7920
gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg gcgaacgcga cgacgcggcg 7980
gttgatctcc tgaatctggc gcctctgcgt gaagacgacg ggcccggtga gcttgagcct 8040
gaaagagagt tcgacagaat caatttcggt gtcgttgacg gcggcctggc gcaaaatctc 8100
ctgcacgtct cctgagttgt cttgataggc gatctcggcc atgaactgct cgatctcttc 8160
ctcctggaga tctccgcgtc cggctcgctc cacggtggcg gcgaggtcgt tggaaatgcg 8220
ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc cagacgcggc tgtagaccac 8280
gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg agattgagct ccacgtgccg 8340
ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag ttgagggtgg tggcggtgtg 8400
ttctgccacg aagaagtaca taacccagcg tcgcaacgtg gattcgttga tatcccccaa 8460
ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg aagttgaaaa actgggagtt 8520
gcgcgccgac acggttaact cctcctccag aagacggatg agctcggcga cagtgtcgcg 8580
cacctcgcgc tcaaaggcta caggggcctc ttcttcttct tcaatctcct cttccataag 8640
ggcctcccct tcttcttctt ctggcggcgg tgggggaggg gggacacggc ggcgacgacg 8700
gcgcaccggg aggcggtcga caaagcgctc gatcatctcc ccgcggcgac ggcgcatggt 8760
ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg aagacgccgc ccgtcatgtc 8820
ccggttatgg gttggcgggg ggctgccatg cggcagggat acggcgctaa cgatgcatct 8880
caacaattgt tgtgtaggta ctccgccgcc gagggacctg agcgagtccg catcgaccgg 8940
atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac 9000
cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat 9060
gtaattaaag taggcggtct tgagacggcg gatggtcgac agaagcacca tgtccttggg 9120
tccggcctgc tgaatgcgca ggcggtcggc catgccccag gcttcgtttt gacatcggcg 9180
caggtctttg tagtagtctt gcatgagcct ttctaccggc acttcttctt ctccttcctc 9240
ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg gagtttggcc gtaggtggcg 9300
ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc ggctgaagca gggctaggtc 9360
ggcgacaacg cgctcggcta atatggcctg ctgcacctgc gtgagggtag actggaagtc 9420
atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg gtgtaagtgc agttggccat 9480
aacggaccag ttaacggtct ggtgacccgg ctgcgagagc tcggtgtacc tgagacgcga 9540
gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc accaggtact ggtatcccac 9600
caaaaagtgc ggcggcggct ggcggtagag gggccagcgt agggtggccg gggctccggg 9660
ggcgagatct tccaacataa ggcgatgata tccgtagatg tacctggaca tccaggtgat 9720
gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg cggttccaga tgttgcgcag 9780
cggcaaaaag tgctccatgg tcgggacgct ctggccggtc aggcgcgcgc aatcgttgac 9840
gctctagacc gtgcaaaagg agagcctgta agcgggcact cttccgtggt ctggtggata 9900
aattcgcaag ggtatcatgg cggacgaccg gggttcgagc cccgtatccg gccgtccgcc 9960
gtgatccatg cggttaccgc ccgcgtgtcg aacccaggtg tgcgacgtca gacaacgggg 10020
gagtgctcct tttggcttcc ttccaggcgc ggcggctgct gcgctagctt ttttggccac 10080
tggccgcgcg cagcgtaagc ggttaggctg gaaagcgaaa gcattaagtg gctcgctccc 10140
tgtagccgga gggttatttt ccaagggttg agtcgcggga cccccggttc gagtctcgga 10200
ccggccggac tgcggcgaac gggggtttgc ctccccgtca tgcaagaccc cgcttgcaaa 10260
ttcctccgga aacagggacg agcccctttt ttgcttttcc cagatgcatc cggtgctgcg 10320
gcagatgcgc ccccctcctc agcagcggca agagcaagag cagcggcaga catgcagggc 10380
accctcccct cctcctaccg cgtcaggagg ggcgacatcc gcggttgacg cggcagcaga 10440
tggtgattac gaacccccgc ggcgccgggc ccggcactac ctggacttgg aggagggcga 10500
gggcctggcg cggctaggag cgccctctcc tgagcggtac ccaagggtgc agctgaagcg 10560
tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt cgcgaccgcg agggagagga 10620
gcccgaggag atgcgggatc gaaagttcca cgcagggcgc gagctgcggc atggcctgaa 10680
tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac gcgcgaaccg ggattagtcc 10740
cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca tacgagcaga cggtgaacca 10800
ggagattaac tttcaaaaaa gctttaacaa ccacgtgcgt acgcttgtgg cgcgcgagga 10860
ggtggctata ggactgatgc atctgtggga ctttgtaagc gcgctggagc aaaacccaaa 10920
tagcaagccg ctcatggcgc agctgttcct tatagtgcag cacagcaggg acaacgaggc 10980
attcagggat gcgctgctaa acatagtaga gcccgagggc cgctggctgc tcgatttgat 11040
aaacatcctg cagagcatag tggtgcagga gcgcagcttg agcctggctg acaaggtggc 11100
cgccatcaac tattccatgc ttagcctggg caagttttac gcccgcaaga tataccatac 11160
cccttacgtt cccatagaca aggaggtaaa gatcgagggg ttctacatgc gcatggcgct 11220
gaaggtgctt accttgagcg acgacctggg cgtttatcgc aacgagcgca tccacaaggc 11280
cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag ctgatgcaca gcctgcaaag 11340
ggccctggct ggcacgggca gcggcgatag agaggccgag tcctactttg acgcgggcgc 11400
tgacctgcgc tgggccccaa gccgacgcgc cctggaggca gctggggccg gacctgggct 11460
ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg gaggaatatg acgaggacga 11520
tgagtacgag ccagaggacg gcgagtacta agcggtgatg tttctgatca gatgatgcaa 11580
gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc agccgtccgg ccttaactcc 11640
acggacgact ggcgccaggt catggaccgc atcatgtcgc tgactgcgcg caatcctgac 11700
gcgttccggc agcagccgca ggccaaccgg ctctccgcaa ttctggaagc ggtggtcccg 11760
gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg taaacgcgct ggccgaaaac 11820
agggccatcc ggcccgacga ggccggcctg gtctacgacg cgctgcttca gcgcgtggct 11880
cgttacaaca gcggcaacgt gcagaccaac ctggaccggc tggtggggga tgtgcgcgag 11940
gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc tgggctccat ggttgcacta 12000
aacgccttcc tgagtacaca gcccgccaac gtgccgcggg gacaggagga ctacaccaac 12060
tttgtgagcg cactgcggct aatggtgact gagacaccgc aaagtgaggt gtaccagtct 12120
gggccagact attttttcca gaccagtaga caaggcctgc agaccgtaaa cctgagccag 12180
gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc ccacaggcga ccgcgcgacc 12240
gtgtctagct tgctgacgcc caactcgcgc ctgttgctgc tgctaatagc gcccttcacg 12300
gacagtggca gcgtgtcccg ggacacatac ctaggtcact tgctgacact gtaccgcgag 12360
gccataggtc aggcgcatgt ggacgagcat actttccagg agattacaag tgtcagccgc 12420
gcgctggggc aggaggacac gggcagcctg gaggcaaccc taaactacct gctgaccaac 12480
cggcggcaga agatcccctc gttgcacagt ttaaacagcg aggaggagcg cattttgcgc 12540
tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg gggtaacgcc cagcgtggcg 12600
ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg cctcaaaccg gccgtttatc 12660
aaccgcctaa tggactactt gcatcgcgcg gccgccgtga accccgagta tttcaccaat 12720
gccatcttga acccgcactg gctaccgccc cctggtttct acaccggggg attcgaggtg 12780
cccgagggta acgatggatt cctctgggac gacatagacg acagcgtgtt ttccccgcaa 12840
ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag aggcggcgct gcgaaaggaa 12900
agcttccgca ggccaagcag cttgtccgat ctaggcgctg cggccccgcg gtcagatgct 12960
agtagcccat ttccaagctt gatagggtct cttaccagca ctcgcaccac ccgcccgcgc 13020
ctgctgggcg aggaggagta cctaaacaac tcgctgctgc agccgcagcg cgaaaaaaac 13080
ctgcctccgg catttcccaa caacgggata gagagcctag tggacaagat gagtagatgg 13140
aagacgtacg cgcaggagca cagggacgtg ccaggcccgc gcccgcccac ccgtcgtcaa 13200
aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg actcggcaga cgacagcagc 13260
gtcctggatt tgggagggag tggcaacccg tttgcgcacc ttcgccccag gctggggaga 13320
atgttttaaa aaaaaaaaag catgatgcaa aataaaaaac tcaccaaggc catggcaccg 13380
agcgttggtt ttcttgtatt ccccttagta tgcggcgcgc ggcgatgtat gaggaaggtc 13440
ctcctccctc ctacgagagt gtggtgagcg cggcgccagt ggcggcggcg ctgggttctc 13500
ccttcgatgc tcccctggac ccgccgtttg tgcctccgcg gtacctgcgg cctaccgggg 13560
ggagaaacag catccgttac tctgagttgg cacccctatt cgacaccacc cgtgtgtacc 13620
tggtggacaa caagtcaacg gatgtggcat ccctgaacta ccagaacgac cacagcaact 13680
ttctgaccac ggtcattcaa aacaatgact acagcccggg ggaggcaagc acacagacca 13740
tcaatcttga cgaccggtcg cactggggcg gcgacctgaa aaccatcctg cataccaaca 13800
tgccaaatgt gaacgagttc atgtttacca ataagtttaa ggcgcgggtg atggtgtcgc 13860
gcttgcctac taaggacaat caggtggagc tgaaatacga gtgggtggag ttcacgctgc 13920
ccgagggcaa ctactccgag accatgacca tagaccttat gaacaacgcg atcgtggagc 13980
actacttgaa agtgggcaga cagaacgggg ttctggaaag cgacatcggg gtaaagtttg 14040
acacccgcaa cttcagactg gggtttgacc ccgtcactgg tcttgtcatg cctggggtat 14100
atacaaacga agccttccat ccagacatca ttttgctgcc aggatgcggg gtggacttca 14160
cccacagccg cctgagcaac ttgttgggca tccgcaagcg gcaacccttc caggagggct 14220
ttaggatcac ctacgatgat ctggagggtg gtaacattcc cgcactgttg gatgtggacg 14280
cctaccaggc gagcttgaaa gatgacaccg aacagggcgg gggtggcgca ggcggcagca 14340
acagcagtgg cagcggcgcg gaagagaact ccaacgcggc agccgcggca atgcagccgg 14400
tggaggacat gaacgatcat gccattcgcg gcgacacctt tgccacacgg gctgaggaga 14460
agcgcgctga ggccgaagca gcggccgaag ctgccgcccc cgctgcgcaa cccgaggtcg 14520
agaagcctca gaagaaaccg gtgatcaaac ccctgacaga ggacagcaag aaacgcagtt 14580
acaacctaat aagcaatgac agcaccttca cccagtaccg cagctggtac cttgcataca 14640
actacggcga ccctcagacc ggaatccgct catggaccct gctttgcact cctgacgtaa 14700
cctgcggctc ggagcaggtc tactggtcgt tgccagacat gatgcaagac cccgtgacct 14760
tccgctccac gcgccagatc agcaactttc cggtggtggg cgccgagctg ttgcccgtgc 14820
actccaagag cttctacaac gaccaggccg tctactccca actcatccgc cagtttacct 14880
ctctgaccca cgtgttcaat cgctttcccg agaaccagat tttggcgcgc ccgccagccc 14940
ccaccatcac caccgtcagt gaaaacgttc ctgctctcac agatcacggg acgctaccgc 15000
tgcgcaacag catcggagga gtccagcgag tgaccattac tgacgccaga cgccgcacct 15060
gcccctacgt ttacaaggcc ctgggcatag tctcgccgcg cgtcctatcg agccgcactt 15120
tttgagcaag catgtccatc cttatatcgc ccagcaataa cacaggctgg ggcctgcgct 15180
tcccaagcaa gatgtttggc ggggccaaga agcgctccga ccaacaccca gtgcgcgtgc 15240
gcgggcacta ccgcgcgccc tggggcgcgc acaaacgcgg ccgcactggg cgcaccaccg 15300
tcgatgacgc catcgacgcg gtggtggagg aggcgcgcaa ctacacgccc acgccgccac 15360
cagtgtccac agtggacgcg gccattcaga ccgtggtgcg cggagcccgg cgctatgcta 15420
aaatgaagag acggcggagg cgcgtagcac gtcgccaccg ccgccgaccc ggcactgccg 15480
cccaacgcgc ggcggcggcc ctgcttaacc gcgcacgtcg caccggccga cgggcggcca 15540
tgcgggccgc tcgaaggctg gccgcgggta ttgtcactgt gccccccagg tccaggcgac 15600
gagcggccgc cgcagcagcc gcggccatta gtgctatgac tcagggtcgc aggggcaacg 15660
tgtattgggt gcgcgactcg gttagcggcc tgcgcgtgcc cgtgcgcacc cgccccccgc 15720
gcaactagat tgcaagaaaa aactacttag actcgtactg ttgtatgtat ccagcggcgg 15780
cggcgcgcaa cgaagctatg tccaagcgca aaatcaaaga agagatgctc caggtcatcg 15840
cgccggagat ctatggcccc ccgaagaagg aagagcagga ttacaagccc cgaaagctaa 15900
agcgggtcaa aaagaaaaag aaagatgatg atgatgaact tgacgacgag gtggaactgc 15960
tgcacgctac cgcgcccagg cgacgggtac agtggaaagg tcgacgcgta aaacgtgttt 16020
tgcgacccgg caccaccgta gtctttacgc ccggtgagcg ctccacccgc acctacaagc 16080
gcgtgtatga tgaggtgtac ggcgacgagg acctgcttga gcaggccaac gagcgcctcg 16140
gggagtttgc ctacggaaag cggcataagg acatgctggc gttgccgctg gacgagggca 16200
acccaacacc tagcctaaag cccgtaacac tgcagcaggt gctgcccgcg cttgcaccgt 16260
ccgaagaaaa gcgcggccta aagcgcgagt ctggtgactt ggcacccacc gtgcagctga 16320
tggtacccaa gcgccagcga ctggaagatg tcttggaaaa aatgaccgtg gaacctgggc 16380
tggagcccga ggtccgcgtg cggccaatca agcaggtggc gccgggactg ggcgtgcaga 16440
ccgtggacgt tcagataccc actaccagta gcaccagtat tgccaccgcc acagagggca 16500
tggagacaca aacgtccccg gttgcctcag cggtggcgga tgccgcggtg caggcggtcg 16560
ctgcggccgc gtccaagacc tctacggagg tgcaaacgga cccgtggatg tttcgcgttt 16620
cagccccccg gcgcccgcgc ggttcgagga agtacggcgc cgccagcgcg ctactgcccg 16680
aatatgccct acatccttcc attgcgccta cccccggcta tcgtggctac acctaccgcc 16740
ccagaagacg agcaactacc cgacgccgaa ccaccactgg aacccgccgc cgccgtcgcc 16800
gtcgccagcc cgtgctggcc ccgatttccg tgcgcagggt ggctcgcgaa ggaggcagga 16860
ccctggtgct gccaacagcg cgctaccacc ccagcatcgt ttaaaagccg gtctttgtgg 16920
ttcttgcaga tatggccctc acctgccgcc tccgtttccc ggtgccggga ttccgaggaa 16980
gaatgcaccg taggaggggc atggccggcc acggcctgac gggcggcatg cgtcgtgcgc 17040
accaccggcg gcggcgcgcg tcgcaccgtc gcatgcgcgg cggtatcctg cccctcctta 17100
ttccactgat cgccgcggcg attggcgccg tgcccggaat tgcatccgtg gccttgcagg 17160
cgcagagaca ctgattaaaa acaagttgca tgtggaaaaa tcaaaataaa aagtctggac 17220
tctcacgctc gcttggtcct gtaactattt tgtagaatgg aagacatcaa ctttgcgtct 17280
ctggccccgc gacacggctc gcgcccgttc atgggaaact ggcaagatat cggcaccagc 17340
aatatgagcg gtggcgcctt cagctggggc tcgctgtgga gcggcattaa aaatttcggt 17400
tccaccgtta agaactatgg cagcaaggcc tggaacagca gcacaggcca gatgctgagg 17460
gataagttga aagagcaaaa tttccaacaa aaggtggtag atggcctggc ctctggcatt 17520
agcggggtgg tggacctggc caaccaggca gtgcaaaata agattaacag taagcttgat 17580
ccccgccctc ccgtagagga gcctccaccg gccgtggaga cagtgtctcc agaggggcgt 17640
ggcgaaaagc gtccgcgccc cgacagggaa gaaactctgg tgacgcaaat agacgagcct 17700
ccctcgtacg aggaggcact aaagcaaggc ctgcccacca cccgtcccat cgcgcccatg 17760
gctaccggag tgctgggcca gcacacaccc gtaacgctgg acctgcctcc ccccgccgac 17820
acccagcaga aacctgtgct gccaggcccg accgccgttg ttgtaacccg tcctagccgc 17880
gcgtccctgc gccgcgccgc cagcggtccg cgatcgttgc ggcccgtagc cagtggcaac 17940
tggcaaagca cactgaacag catcgtgggt ctgggggtgc aatccctgaa gcgccgacga 18000
tgcttctgaa tagctaacgt gtcgtatgtg tgtcatgtat gcgtccatgt cgccgccaga 18060
ggagctgctg agccgccgcg cgcccgcttt ccaagatggc taccccttcg atgatgccgc 18120
agtggtctta catgcacatc tcgggccagg acgcctcgga gtacctgagc cccgggctgg 18180
tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa taacaagttt agaaacccca 18240
cggtggcgcc tacgcacgac gtgaccacag accggtccca gcgtttgacg ctgcggttca 18300
tccctgtgga ccgtgaggat actgcgtact cgtacaaggc gcggttcacc ctagctgtgg 18360
gtgataaccg tgtgctggac atggcttcca cgtactttga catccgcggc gtgctggaca 18420
ggggccctac ttttaagccc tactctggca ctgcctacaa cgccctggct cccaagggtg 18480
ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct tgaaataaac ctagaagaag 18540
aggacgatga caacgaagac gaagtagacg agcaagctga gcagcaaaaa actcacgtat 18600
ttgggcaggc gccttattct ggtataaata ttacaaagga gggtattcaa ataggtgtcg 18660
aaggtcaaac acctaaatat gccgataaaa catttcaacc tgaacctcaa ataggagaat 18720
ctcagtggta cgaaactgaa attaatcatg cagctgggag agtccttaaa aagactaccc 18780
caatgaaacc atgttacggt tcatatgcaa aacccacaaa tgaaaatgga gggcaaggca 18840
ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt ggaaatgcaa tttttctcaa 18900
ctactgaggc gaccgcaggc aatggtgata acttgactcc taaagtggta ttgtacagtg 18960
aagatgtaga tatagaaacc ccagacactc atatttctta catgcccact attaaggaag 19020
gtaactcacg agaactaatg ggccaacaat ctatgcccaa caggcctaat tacattgctt 19080
ttagggacaa ttttattggt ctaatgtatt acaacagcac gggtaatatg ggtgttctgg 19140
cgggccaagc atcgcagttg aatgctgttg tagatttgca agacagaaac acagagcttt 19200
cataccagct tttgcttgat tccattggtg atagaaccag gtacttttct atgtggaatc 19260
aggctgttga cagctatgat ccagatgtta gaattattga aaatcatgga actgaagatg 19320
aacttccaaa ttactgcttt ccactgggag gtgtgattaa tacagagact cttaccaagg 19380
taaaacctaa aacaggtcag gaaaatggat gggaaaaaga tgctacagaa ttttcagata 19440
aaaatgaaat aagagttgga aataattttg ccatggaaat caatctaaat gccaacctgt 19500
ggagaaattt cctgtactcc aacatagcgc tgtatttgcc cgacaagcta aagtacagtc 19560
cttccaacgt aaaaatttct gataacccaa acacctacga ctacatgaac aagcgagtgg 19620
tggctcccgg gttagtggac tgctacatta accttggagc acgctggtcc cttgactata 19680
tggacaacgt caacccattt aaccaccacc gcaatgctgg cctgcgctac cgctcaatgt 19740
tgctgggcaa tggtcgctat gtgcccttcc acatccaggt gcctcagaag ttctttgcca 19800
ttaaaaacct ccttctcctg ccgggctcat acacctacga gtggaacttc aggaaggatg 19860
ttaacatggt tctgcagagc tccctaggaa atgacctaag ggttgacgga gccagcatta 19920
agtttgatag catttgcctt tacgccacct tcttccccat ggcccacaac accgcctcca 19980
cgcttgaggc catgcttaga aacgacacca acgaccagtc ctttaacgac tatctctccg 20040
ccgccaacat gctctaccct atacccgcca acgctaccaa cgtgcccata tccatcccct 20100
cccgcaactg ggcggctttc cgcggctggg ccttcacgcg ccttaagact aaggaaaccc 20160
catcactggg ctcgggctac gacccttatt acacctactc tggctctata ccctacctag 20220
atggaacctt ttacctcaac cacaccttta agaaggtggc cattaccttt gactcttctg 20280
tcagctggcc tggcaatgac cgcctgctta cccccaacga gtttgaaatt aagcgctcag 20340
ttgacgggga gggttacaac gttgcccagt gtaacatgac caaagactgg ttcctggtac 20400
aaatgctagc taactacaac attggctacc agggcttcta tatcccagag agctacaagg 20460
accgcatgta ctccttcttt agaaacttcc agcccatgag ccgtcaggtg gtggatgata 20520
ctaaatacaa ggactaccaa caggtgggca tcctacacca acacaacaac tctggatttg 20580
ttggctacct tgcccccacc atgcgcgaag gacaggccta ccctgctaac ttcccctatc 20640
cgcttatagg caagaccgca gttgacagca ttacccagaa aaagtttctt tgcgatcgca 20700
ccctttggcg catcccattc tccagtaact ttatgtccat gggcgcactc acagacctgg 20760
gccaaaacct tctctacgcc aactccgccc acgcgctaga catgactttt gaggtggatc 20820
ccatggacga gcccaccctt ctttatgttt tgtttgaagt ctttgacgtg gtccgtgtgc 20880
accggccgca ccgcggcgtc atcgaaaccg tgtacctgcg cacgcccttc tcggccggca 20940
acgccacaac ataaagaagc aagcaacatc aacaacagct gccgccatgg gctccagtga 21000
gcaggaactg aaagccattg tcaaagatct tggttgtggg ccatattttt tgggcaccta 21060
tgacaagcgc tttccaggct ttgtttctcc acacaagctc gcctgcgcca tagtcaatac 21120
ggccggtcgc gagactgggg gcgtacactg gatggccttt gcctggaacc cgcactcaaa 21180
aacatgctac ctctttgagc cctttggctt ttctgaccag cgactcaagc aggtttacca 21240
gtttgagtac gagtcactcc tgcgccgtag cgccattgct tcttcccccg accgctgtat 21300
aacgctggaa aagtccaccc aaagcgtaca ggggcccaac tcggccgcct gtggactatt 21360
ctgctgcatg tttctccacg cctttgccaa ctggccccaa actcccatgg atcacaaccc 21420
caccatgaac cttattaccg gggtacccaa ctccatgctc aacagtcccc aggtacagcc 21480
caccctgcgt cgcaaccagg aacagctcta cagcttcctg gagcgccact cgccctactt 21540
ccgcagccac agtgcgcaga ttaggagcgc cacttctttt tgtcacttga aaaacatgta 21600
aaaataatgt actagagaca ctttcaataa aggcaaatgc ttttatttgt acactctcgg 21660
gtgattattt acccccaccc ttgccgtctg cgccgtttaa aaatcaaagg ggttctgccg 21720
cgcatcgcta tgcgccactg gcagggacac gttgcgatac tggtgtttag tgctccactt 21780
aaactcaggc acaaccatcc gcggcagctc ggtgaagttt tcactccaca ggctgcgcac 21840
catcaccaac gcgtttagca ggtcgggcgc cgatatcttg aagtcgcagt tggggcctcc 21900
gccctgcgcg cgcgagttgc gatacacagg gttgcagcac tggaacacta tcagcgccgg 21960
gtggtgcacg ctggccagca cgctcttgtc ggagatcaga tccgcgtcca ggtcctccgc 22020
gttgctcagg gcgaacggag tcaactttgg tagctgcctt cccaaaaagg gcgcgtgccc 22080
aggctttgag ttgcactcgc accgtagtgg catcaaaagg tgaccgtgcc cggtctgggc 22140
gttaggatac agcgcctgca taaaagcctt gatctgctta aaagccacct gagcctttgc 22200
gccttcagag aagaacatgc cgcaagactt gccggaaaac tgattggccg gacaggccgc 22260
gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc accacatttc ggccccaccg 22320
gttcttcacg atcttggcct tgctagactg ctccttcagc gcgcgctgcc cgttttcgct 22380
cgtcacatcc atttcaatca cgtgctcctt atttatcata atgcttccgt gtagacactt 22440
aagctcgcct tcgatctcag cgcagcggtg cagccacaac gcgcagcccg tgggctcgtg 22500
atgcttgtag gtcacctctg caaacgactg caggtacgcc tgcaggaatc gccccatcat 22560
cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac ccgcggtgct cctcgttcag 22620
ccaggtcttg catacggccg ccagagcttc cacttggtca ggcagtagtt tgaagttcgc 22680
ctttagatcg ttatccacgt ggtacttgtc catcagcgcg cgcgcagcct ccatgccctt 22740
ctcccacgca gacacgatcg gcacactcag cgggttcatc accgtaattt cactttccgc 22800
ttcgctgggc tcttcctctt cctcttgcgt ccgcatacca cgcgccactg ggtcgtcttc 22860
attcagccgc cgcactgtgc gcttacctcc tttgccatgc ttgattagca ccggtgggtt 22920
gctgaaaccc accatttgta gcgccacatc ttctctttct tcctcgctgt ccacgattac 22980
ctctggtgat ggcgggcgct cgggcttggg agaagggcgc ttctttttct tcttgggcgc 23040
aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg ggtgtgcgcg gcaccagcgc 23100
gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc cgcctcatcc gcttttttgg 23160
gggcgcccgg ggaggcggcg gcgacgggga cggggacgac acgtcctcca tggttggggg 23220
acgtcgcgcc gcaccgcgtc cgcgctcggg ggtggtttcg cgctgctcct cttcccgact 23280
ggccatttcc ttctcctata ggcagaaaaa gatcatggag tcagtcgaga agaaggacag 23340
cctaaccgcc ccctctgagt tcgccaccac cgcctccacc gatgccgcca acgcgcctac 23400
caccttcccc gtcgaggcac ccccgcttga ggaggaggaa gtgattatcg agcaggaccc 23460
aggttttgta agcgaagacg acgaggaccg ctcagtacca acagaggata aaaagcaaga 23520
ccaggacaac gcagaggcaa acgaggaaca agtcgggcgg ggggacgaaa ggcatggcga 23580
ctacctagat gtgggagacg acgtgctgtt gaagcatctg cagcgccagt gcgccattat 23640
ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc atagcggatg tcagccttgc 23700
ctacgaacgc cacctattct caccgcgcgt accccccaaa cgccaagaaa acggcacatg 23760
cgagcccaac ccgcgcctca acttctaccc cgtatttgcc gtgccagagg tgcttgccac 23820
ctatcacatc tttttccaaa actgcaagat acccctatcc tgccgtgcca accgcagccg 23880
agcggacaag cagctggcct tgcggcaggg cgctgtcata cctgatatcg cctcgctcaa 23940
cgaagtgcca aaaatctttg agggtcttgg acgcgacgag aagcgcgcgg caaacgctct 24000
gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg ttggtggaac tcgagggtga 24060
caacgcgcgc ctagccgtac taaaacgcag catcgaggtc acccactttg cctacccggc 24120
acttaaccta ccccccaagg tcatgagcac agtcatgagt gagctgatcg tgcgccgtgc 24180
gcagcccctg gagagggatg caaatttgca agaacaaaca gaggagggcc tacccgcagt 24240
tggcgacgag cagctagcgc gctggcttca aacgcgcgag cctgccgact tggaggagcg 24300
acgcaaacta atgatggccg cagtgctcgt taccgtggag cttgagtgca tgcagcggtt 24360
ctttgctgac ccggagatgc agcgcaagct agaggaaaca ttgcactaca cctttcgaca 24420
gggctacgta cgccaggcct gcaagatctc caacgtggag ctctgcaacc tggtctccta 24480
ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg cttcattcca cgctcaaggg 24540
cgaggcgcgc cgcgactacg tccgcgactg cgtttactta tttctatgct acacctggca 24600
gacggccatg ggcgtttggc agcagtgctt ggaggagtgc aacctcaagg agctgcagaa 24660
actgctaaag caaaacttga aggacctatg gacggccttc aacgagcgct ccgtggccgc 24720
gcacctggcg gacatcattt tccccgaacg cctgcttaaa accctgcaac agggtctgcc 24780
agacttcacc agtcaaagca tgttgcagaa ctttaggaac tttatcctag agcgctcagg 24840
aatcttgccc gccacctgct gtgcacttcc tagcgacttt gtgcccatta agtaccgcga 24900
atgccctccg ccgctttggg gccactgcta ccttctgcag ctagccaact accttgccta 24960
ccactctgac ataatggaag acgtgagcgg tgacggtcta ctggagtgtc actgtcgctg 25020
caacctatgc accccgcacc gctccctggt ttgcaattcg cagctgctta acgaaagtca 25080
aattatcggt acctttgagc tgcagggtcc ctcgcctgac gaaaagtccg cggctccggg 25140
gttgaaactc actccggggc tgtggacgtc ggcttacctt cgcaaatttg tacctgagga 25200
ctaccacgcc cacgagatta ggttctacga agaccaatcc cgcccgccaa atgcggagct 25260
taccgcctgc gtcattaccc agggccacat tcttggccaa ttgcaagcca tcaacaaagc 25320
ccgccaagag tttctgctac gaaagggacg gggggtttac ttggaccccc agtccggcga 25380
ggagctcaac ccaatccccc cgccgccgca gccctatcag cagcagccgc gggcccttgc 25440
ttcccaggat ggcacccaaa aagaagctgc agctgccgcc gccacccacg gacgaggagg 25500
aatactggga cagtcaggca gaggaggttt tggacgagga ggaggaggac atgatggaag 25560
actgggagag cctagacgag gaagcttccg aggtcgaaga ggtgtcagac gaaacaccgt 25620
caccctcggt cgcattcccc tcgccggcgc cccagaaatc ggcaaccggt tccagcatgg 25680
ctacaacctc cgctcctcag gcgccgccgg cactgcccgt tcgccgaccc aaccgtagat 25740
gggacaccac tggaaccagg gccggtaagt ccaagcagcc gccgccgtta gcccaagagc 25800
aacaacagcg ccaaggctac cgctcatggc gcgggcacaa gaacgccata gttgcttgct 25860
tgcaagactg tgggggcaac atctccttcg cccgccgctt tcttctctac catcacggcg 25920
tggccttccc ccgtaacatc ctgcattact accgtcatct ctacagccca tactgcaccg 25980
gcggcagcgg cagcggcagc aacagcagcg gccacacaga agcaaaggcg accggatagc 26040
aagactctga caaagcccaa gaaatccaca gcggcggcag cagcaggagg aggagcgctg 26100
cgtctggcgc ccaacgaacc cgtatcgacc cgcgagctta gaaacaggat ttttcccact 26160
ctgtatgcta tatttcaaca gagcaggggc caagaacaag agctgaaaat aaaaaacagg 26220
tctctgcgat ccctcacccg cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc 26280
acgctggaag acgcggaggc tctcttcagt aaatactgcg cgctgactct taaggactag 26340
tttcgcgccc tttctcaaat ttaagcgcga aaactacgtc atctccagcg gccacacccg 26400
gcgccagcac ctgtcgtcag cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg 26460
agttaccagc cacaaatggg acttgcggct ggagctgccc aagactactc aacccgaata 26520
aactacatga gcgcgggacc ccacatgata tcccgggtca acggaatccg cgcccaccga 26580
aaccgaattc tcttggaaca ggcggctatt accaccacac ctcgtaataa ccttaatccc 26640
cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt 26700
cccagagacg cccaggccga agttcagatg actaactcag gggcgcagct tgcgggcggc 26760
tttcgtcaca gggtgcggtc gcccgggcag ggtataactc acctgacaat cagagggcga 26820
ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg gtctccgtcc ggacgggaca 26880
tttcagatcg gcggcgccgg ccgtccttca ttcacgcctc gtcaggcaat cctaactctg 26940
cagacctcgt cctctgagcc gcgctctgga ggcattggaa ctctgcaatt tattgaggag 27000
tttgtgccat cggtctactt taaccccttc tcgggacctc ccggccacta tccggatcaa 27060
tttattccta actttgacgc ggtaaaggac tcggcggacg gctacgactg aatgttaagt 27120
ggagaggcag agcaactgcg cctgaaacac ctggtccact gtcgccgcca caagtgcttt 27180
gcccgcgact ccggtgagtt ttgctacttt gaattgcccg aggatcatat cgagggcccg 27240
gcgcacggcg tccggcttac cgcccaggga gagcttgccc gtagcctgat tcgggagttt 27300
acccagcgcc ccctgctagt tgagcgggac aggggaccct gtgttctcac tgtgatttgc 27360
aactgtccta accttggatt acatcaagat ctttgttgcc atctctgtgc tgagtataat 27420
aaatacagaa attaaaatat actggggctc ctatcgccat cctgtaaacg ccaccgtctt 27480
cacccgccca agcaaaccaa ggcgaacctt acctggtact tttaacatct ctccctctgt 27540
gatttacaac agtttcaacc cagacggagt gagtctacga gagaacctct ccgagctcag 27600
ctactccatc agaaaaaaca ccaccctcct tacctgccgg gaacgtacga gtgcgtcacc 27660
ggccgctgca ccacacctac cgcctgaccg taaaccagac tttttccgga cagacctcaa 27720
taactctgtt taccagaaca ggaggtgagc ttagaaaacc cttagggtat taggccaaag 27780
gcgcagctac tgtggggttt atgaacaatt caagcaactc tacgggctat tctaattcag 27840
gtttctctag aaatggacgg aattattaca gagcagcgcc tgctagaaag acgcagggca 27900
gcggccgagc aacagcgcat gaatcaagag ctccaagaca tggttaactt gcaccagtgc 27960
aaaaggggta tcttttgtct ggtaaagcag gccaaagtca cctacgacag taataccacc 28020
ggacaccgcc ttagctacaa gttgccaacc aagcgtcaga aattggtggt catggtggga 28080
gaaaagccca ttaccataac tcagcactcg gtagaaaccg aaggctgcat tcactcacct 28140
tgtcaaggac ctgaggatct ctgcaccctt attaagaccc tgtgcggtct caaagatctt 28200
attcccttta actaataaaa aaaaataata aagcatcact tacttaaaat cagttagcaa 28260
atttctgtcc agtttattca gcagcacctc cttgccctcc tcccagctct ggtattgcag 28320
cttcctcctg gctgcaaact ttctccacaa tctaaatgga atgtcagttt cctcctgttc 28380
ctgtccatcc gcacccacta tcttcatgtt gttgcagatg aagcgcgcaa gaccgtctga 28440
agataccttc aaccccgtgt atccatatga cacggaaacc ggtcctccaa ctgtgccttt 28500
tcttactcct ccctttgtat cccccaatgg gtttcaagag agtccccctg gggtactctc 28560
tttgcgccta tccgaacctc tagttacctc caatggcatg cttgcgctca aaatgggcaa 28620
cggcctctct ctggacgagg ccggcaacct tacctcccaa aatgtaacca ctgtgagccc 28680
acctctcaaa aaaaccaagt caaacataaa cctggaaata tctgcacccc tcacagttac 28740
ctcagaagcc ctaactgtgg ctgccgccgc acctctaatg gtcgcgggca acacactcac 28800
catgcaatca caggccccgc taaccgtgca cgactccaaa cttagcattg ccacccaagg 28860
acccctcaca gtgtcagaag gaaagctagc cctgcaaaca tcaggccccc tcaccaccac 28920
cgatagcagt acccttacta tcactgcctc accccctcta actactgcca ctggtagctt 28980
gggcattgac ttgaaagagc ccatttatac acaaaatgga aaactaggac taaagtacgg 29040
ggctcctttg catgtaacag acgacctaaa cactttgacc gtagcaactg gtccaggtgt 29100
gactattaat aatacttcct tgcaaactaa agttactgga gccttgggtt ttgattcaca 29160
aggcaatatg caacttaatg tagcaggagg actaaggatt gattctcaaa acagacgcct 29220
tatacttgat gttagttatc cgtttgatgc tcaaaaccaa ctaaatctaa gactaggaca 29280
gggccctctt tttataaact cagcccacaa cttggatatt aactacaaca aaggccttta 29340
cttgtttaca gcttcaaaca attccaaaaa gcttgaggtt aacctaagca ctgccaaggg 29400
gttgatgttt gacgctacag ccatagccat taatgcagga gatgggcttg aatttggttc 29460
acctaatgca ccaaacacaa atcccctcaa aacaaaaatt ggccatggcc tagaatttga 29520
ttcaaacaag gctatggttc ctaaactagg aactggcctt agttttgaca gcacaggtgc 29580
cattacagta ggaaacaaaa ataatgataa gctaactttg tggaccacac cagctccatc 29640
tcctaactgt agactaaatg cagagaaaga tgctaaactc actttggtct taacaaaatg 29700
tggcagtcaa atacttgcta cagtttcagt tttggctgtt aaaggcagtt tggctccaat 29760
atctggaaca gttcaaagtg ctcatcttat tataagattt gacgaaaatg gagtgctact 29820
aaacaattcc ttcctggacc cagaatattg gaactttaga aatggagatc ttactgaagg 29880
cacagcctat acaaacgctg ttggatttat gcctaaccta tcagcttatc caaaatctca 29940
cggtaaaact gccaaaagta acattgtcag tcaagtttac ttaaacggag acaaaactaa 30000
acctgtaaca ctaaccatta cactaaacgg tacacaggaa acaggagaca caactccaag 30060
tgcatactct atgtcatttt catgggactg gtctggccac aactacatta atgaaatatt 30120
tgccacatcc tcttacactt tttcatacat tgcccaagaa taaagaatcg tttgtgttat 30180
gtttcaacgt gtttattttt caattgcaga aaatttcgaa tcatttttca ttcagtagta 30240
tagccccacc accacatagc ttatacagat caccgtacct taatcaaact cacagaaccc 30300
tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc 30360
tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca 30420
cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac 30480
ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct 30540
taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca 30600
ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc 30660
tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa 30720
ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac 30780
tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc 30840
tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt 30900
ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca 30960
ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa 31020
accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat 31080
gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt 31140
tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta 31200
gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa 31260
gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat 31320
gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt 31380
acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc 31440
cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt 31500
ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa 31560
gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg 31620
ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag 31680
tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt attccaaaag 31740
attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc cggtggcgtg 31800
gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca caatggcttc 31860
caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt cagggtgaat 31920
ctcctctata aacattccag caccttcaac catgcccaaa taattctcat ctcgccacct 31980
tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa aaatctgctc 32040
cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa ttcaggttcc 32100
tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg atcccgtagg 32160
tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag cgcggccact 32220
tccccgccag gaaccttgac aaaagaaccc acactgatta tgacacgcat actcggagct 32280
atgctaacca gcgtagcccc gatgtaagct ttgttgcatg ggcggcgata taaaatgcaa 32340
ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg 32400
ctcatgcaga taaaggcagg taagctccgg aaccaccaca gaaaaagaca ccatttttct 32460
ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa aataacaaaa aaacatttaa 32520
acattagaag cctgtcttac aacaggaaaa acaaccctta taagcataag acggactacg 32580
gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac caccgacagc 32640
tcctcggtca tgtccggagt cataatgtaa gactcggtaa acacatcagg ttgattcaca 32700
tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa tacatacccg caggcgtaga 32760
gacaacatta cagcccccat aggaggtata acaaaattaa taggagagaa aaacacataa 32820
acacctgaaa aaccctcctg cctaggcaaa atagcaccct cccgctccag aacaacatac 32880
agcgcttcca cagcggcagc cataacagtc agccttacca gtaaaaaaga aaacctatta 32940
aaaaaacacc actcgacacg gcaccagctc aatcagtcac agtgtaaaaa agggccaagt 33000
gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac 33060
ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct 33120
caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa aactacaatt 33180
cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc 33240
cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt 33300
atattattga tgatgttaat taagggcggc cgcacgggcc atcgatgggg atccatccgc 33360
ggagaagctt ctcgaccaat tctcatgttt gacagcttat catcgaattt ctgccattca 33420
tccgcttatt atcacttatt caggcgtagc aaccaggcgt ttaagggcac caataactgc 33480
cttaaaaaaa ttacgccccg ccctgccact catcgcagta ctgttgtaat tcattaagca 33540
ttctgccgac atggaagcca tcacagacgg catgatgaac ctgaatcgcc agcggcatca 33600
gcaccttgtc gccttgcgta taatatttgc ccatggtgaa aacgggggcg aagaagttgt 33660
ccatattggc cacgtttaaa tcaaaactgg tgaaactcac ccagggattg gctgagacga 33720
aaaacatatt ctcaataaac cctttaggga aataggccag gttttcaccg taacacgcca 33780
catcttgcga atatatgtgt agaaactgcc ggaaatcgtc gtggtattca ctccagagcg 33840
atgaaaacgt ttcagtttgc tcatggaaaa cggtgtaaca agggtgaaca ctatcccata 33900
tcaccagctc accgtctttc attgccatac ggaattccgg atgagcattc atcaggcggg 33960
caagaatgtg aataaaggcc ggataaaact tgtgcttatt tttctttacg gtctttaaaa 34020
aggccgtaat atccagctga acggtctggt tataggtaca ttgagcaact gactgaaatg 34080
cctcaaaatg ttctttacga tgccattggg atatatcaac ggtggtatat ccagtgattt 34140
ttttctccat tttagcttcc ttagctcctg aaaatctcga taactcaaaa aatacgcccg 34200
gtagtgatct tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc 34260
attttcgcca aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt 34320
attctgcgaa gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt 34380
aaccgtcgca caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc 34440
aggacctgga ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt 34500
ccggtcacac cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata 34560
ccgctgaaag ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac 34620
acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag 34680
tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat 34740
ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt 34800
atccactgag aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat 34860
tattaatctc aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc 34920
aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg 34980
ttacgttgaa gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa 35040
ccatgatgtg gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag 35100
ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat 35160
gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt tataattatt 35220
ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg 35280
ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac 35340
agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt 35400
tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa 35460
cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac 35520
gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct 35580
cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca 35640
ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg 35700
gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga 35760
aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt 35820
ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca 35880
acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta 35940
gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt 36000
atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt 36060
accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct 36120
gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag 36180
gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat 36240
agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact 36300
gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt 36360
ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt 36420
ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt 36480
tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt 36540
tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc 36600
ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta 36660
gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat 36720
tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat 36780
tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat 36840
ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc 36900
acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga 36960
agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg 37020
actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat 37080
tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt 37140
atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc 37200
tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa 37260
cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc 37320
agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa 37380
gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga 37440
aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct 37500
ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc 37560
taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac 37620
gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct 37680
gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata 37740
cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg 37800
aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg 37860
gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa 37920
tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg 37980
ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa 38040
ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg 38100
cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg 38160
aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca 38220
ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct 38280
tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa 38340
attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt 38400
ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg taacgattat 38460
cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt 38520
gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc 38580
tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa 38640
ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt 38700
aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa 38760
gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta 38820
agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg 38880
cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt 38940
aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct 39000
ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg 39060
cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt 39120
atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 39180
tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt 39240
cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg 39300
tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 39360
aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 39420
tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta 39480
tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga 39540
ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt 39600
aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa 39660
cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta 39720
accgggctgc atccgatgca agtgtgtcgc tgtcgagttt tcgggggagt ccagggtttt 39780
cccagtcacg acgttgtaaa acgacggcca gtgaattcga gctcggtacc cggggatctt 39840
gaagttccta ttctctagaa agtataggaa cttcaattcc catgtcagcc gttaagtgtt 39900
cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 39960
ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 40020
ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 40080
gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 40140
ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 40200
gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 40260
atcttcagat cctctacgcc ggacgcatcg tggccggatc cgatttattc aacaaagcca 40320
cgttgtgtct caaaatctct gatgttacat tgcacaagat aaaaatatat catcatgaac 40380
aataaaactg tctgcttaca taaacagtaa tacaaggggt gttatgagcc atattcaacg 40440
ggaaacgtct tgctcgaggc cgcgattaaa ttccaacatg gatgctgatt tatatgggta 40500
taaatgggct cgcgataatg tcgggcaatc aggtgcgaca atctatcgat tgtatgggaa 40560
gcccgatgcg ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca atgatgttac 40620
agatgagatg gtcagactaa actggctgac ggaatttatg cctcttccga ccatcaagca 40680
ttttatccgt actcctgatg atgcatggtt actcaccact gcgatccccg ggaaaacagc 40740
attccaggta ttagaagaat atcctgattc aggtgaaaat attgttgatg cgctggcagt 40800
gttcctgcgc cggttgcatt cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt 40860
atttcgtctc gctcaggcgc aatcacgaat gaataacggt ttggttgatg cgagtgattt 40920
tgatgacgag cgtaatggct ggcctgttga acaagtctgg aaagaaatgc ataagctttt 40980
gccattctca ccggattcag tcgtcactca tggtgatttc tcacttgata accttatttt 41040
tgacgagggg aaattaatag gttgtattga tgttggacga gtcggaatcg cagaccgata 41100
ccaggatctt gccatcctat ggaactgcct cggtgagttt tctccttcat tacagaaacg 41160
gctttttcaa aaatatggta ttgataatcc tgatatgaat aaattgcagt ttcatttgat 41220
gctcgatgag tttttc 41236
<210> 53
<211> 49133
<212> DNA
<213> 人工序列
<220>
<223> pBWH-C5-mChe-DD-Cas9
<400> 53
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac ctaattgcag 300
tggaccccgg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac 360
ttgaaaaagt ggcaccgagt cggtgctttt ttaagcttga attcgctagc taggtcttga 420
aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc 480
ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg tggcgcgggg 540
taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac 600
cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa 660
cacaggaccg gttctagagc caccatggga gtgcaggtgg aaaccatctc cccaggtgac 720
gggcgcacct tccccaagcg cggccagacc tgtgtggtgc actacaccgg gatgcttgaa 780
gatggaaaga aagtcgattc ctcccgggac agaaacaagc cctttaagtt tatgctaggc 840
aagcaggagg tgatccgagg ctgggaagaa ggggttgccc agatgagtgt gggtcagaga 900
gccaaactga ctatatctcc agattatgcc tatggtgcca ctgggcaccc aggcatcatc 960
ccaccacatg ccactctcgt cttcgatgtg gagcttctaa aaccggaacc ggctagcgac 1020
aagaagtaca gcatcggcct ggacatcggc accaactctg tgggctgggc cgtgatcacc 1080
gacgagtaca aggtgcccag caagaaattc aaggtgctgg gcaacaccga ccggcacagc 1140
atcaagaaga acctgatcgg agccctgctg ttcgacagcg gcgaaacagc cgaggccacc 1200
cggctgaaga gaaccgccag aagaagatac accagacgga agaaccggat ctgctatctg 1260
caagagatct tcagcaacga gatggccaag gtggacgaca gcttcttcca cagactggaa 1320
gagtccttcc tggtggaaga ggataagaag cacgagcggc accccatctt cggcaacatc 1380
gtggacgagg tggcctacca cgagaagtac cccaccatct accacctgag aaagaaactg 1440
gtggacagca ccgacaaggc cgacctgcgg ctgatctatc tggccctggc ccacatgatc 1500
aagttccggg gccacttcct gatcgagggc gacctgaacc ccgacaacag cgacgtggac 1560
aagctgttca tccagctggt gcagacctac aaccagctgt tcgaggaaaa ccccatcaac 1620
gccagcggcg tggacgccaa ggccatcctg tctgccagac tgagcaagag cagacggctg 1680
gaaaatctga tcgcccagct gcccggcgag aagaagaatg gcctgttcgg aaacctgatt 1740
gccctgagcc tgggcctgac ccccaacttc aagagcaact tcgacctggc cgaggatgcc 1800
aaactgcagc tgagcaagga cacctacgac gacgacctgg acaacctgct ggcccagatc 1860
ggcgaccagt acgccgacct gtttctggcc gccaagaacc tgtccgacgc catcctgctg 1920
agcgacatcc tgagagtgaa caccgagatc accaaggccc ccctgagcgc ctctatgatc 1980
aagagatacg acgagcacca ccaggacctg accctgctga aagctctcgt gcggcagcag 2040
ctgcctgaga agtacaaaga gattttcttc gaccagagca agaacggcta cgccggctac 2100
attgacggcg gagccagcca ggaagagttc tacaagttca tcaagcccat cctggaaaag 2160
atggacggca ccgaggaact gctcgtgaag ctgaacagag aggacctgct gcggaagcag 2220
cggaccttcg acaacggcag catcccccac cagatccacc tgggagagct gcacgccatt 2280
ctgcggcggc aggaagattt ttacccattc ctgaaggaca accgggaaaa gatcgagaag 2340
atcctgacct tccgcatccc ctactacgtg ggccctctgg ccaggggaaa cagcagattc 2400
gcctggatga ccagaaagag cgaggaaacc atcaccccct ggaacttcga ggaagtggtg 2460
gacaagggcg cttccgccca gagcttcatc gagcggatga ccaacttcga taagaacctg 2520
cccaacgaga aggtgctgcc caagcacagc ctgctgtacg agtacttcac cgtgtataac 2580
gagctgacca aagtgaaata cgtgaccgag ggaatgagaa agcccgcctt cctgagcggc 2640
gagcagaaaa aggccatcgt ggacctgctg ttcaagacca accggaaagt gaccgtgaag 2700
cagctgaaag aggactactt caagaaaatc gagtgcttcg actccgtgga aatctccggc 2760
gtggaagatc ggttcaacgc ctccctgggc acataccacg atctgctgaa aattatcaag 2820
gacaaggact tcctggacaa tgaggaaaac gaggacattc tggaagatat cgtgctgacc 2880
ctgacactgt ttgaggacag agagatgatc gaggaacggc tgaaaaccta tgcccacctg 2940
ttcgacgaca aagtgatgaa gcagctgaag cggcggagat acaccggctg gggcaggctg 3000
agccggaagc tgatcaacgg catccgggac aagcagtccg gcaagacaat cctggatttc 3060
ctgaagtccg acggcttcgc caacagaaac ttcatgcagc tgatccacga cgacagcctg 3120
acctttaaag aggacatcca gaaagcccag gtgtccggcc agggcgatag cctgcacgag 3180
cacattgcca atctggccgg cagccccgcc attaagaagg gcatcctgca gacagtgaag 3240
gtggtggacg agctcgtgaa agtgatgggc cggcacaagc ccgagaacat cgtgatcgaa 3300
atggccagag agaaccagac cacccagaag ggacagaaga acagccgcga gagaatgaag 3360
cggatcgaag agggcatcaa agagctgggc agccagatcc tgaaagaaca ccccgtggaa 3420
aacacccagc tgcagaacga gaagctgtac ctgtactacc tgcagaatgg gcgggatatg 3480
tacgtggacc aggaactgga catcaaccgg ctgtccgact acgatgtgga ccatatcgtg 3540
cctcagagct ttctgaagga cgactccatc gacaacaagg tgctgaccag aagcgacaag 3600
aaccggggca agagcgacaa cgtgccctcc gaagaggtcg tgaagaagat gaagaactac 3660
tggcggcagc tgctgaacgc caagctgatt acccagagaa agttcgacaa tctgaccaag 3720
gccgagagag gcggcctgag cgaactggat aaggccggct tcatcaagag acagctggtg 3780
gaaacccggc agatcacaaa gcacgtggca cagatcctgg actcccggat gaacactaag 3840
tacgacgaga atgacaagct gatccgggaa gtgaaagtga tcaccctgaa gtccaagctg 3900
gtgtccgatt tccggaagga tttccagttt tacaaagtgc gcgagatcaa caactaccac 3960
cacgcccacg acgcctacct gaacgccgtc gtgggaaccg ccctgatcaa aaagtaccct 4020
aagctggaaa gcgagttcgt gtacggcgac tacaaggtgt acgacgtgcg gaagatgatc 4080
gccaagagcg agcaggaaat cggcaaggct accgccaagt acttcttcta cagcaacatc 4140
atgaactttt tcaagaccga gattaccctg gccaacggcg agatccggaa gcggcctctg 4200
atcgagacaa acggcgaaac cggggagatc gtgtgggata agggccggga ttttgccacc 4260
gtgcggaaag tgctgagcat gccccaagtg aatatcgtga aaaagaccga ggtgcagaca 4320
ggcggcttca gcaaagagtc tatcctgccc aagaggaaca gcgataagct gatcgccaga 4380
aagaaggact gggaccctaa gaagtacggc ggcttcgaca gccccaccgt ggcctattct 4440
gtgctggtgg tggccaaagt ggaaaagggc aagtccaaga aactgaagag tgtgaaagag 4500
ctgctgggga tcaccatcat ggaaagaagc agcttcgaga agaatcccat cgactttctg 4560
gaagccaagg gctacaaaga agtgaaaaag gacctgatca tcaagctgcc taagtactcc 4620
ctgttcgagc tggaaaacgg ccggaagaga atgctggcct ctgccggcga actgcagaag 4680
ggaaacgaac tggccctgcc ctccaaatat gtgaacttcc tgtacctggc cagccactat 4740
gagaagctga agggctcccc cgaggataat gagcagaaac agctgtttgt ggaacagcac 4800
aagcactacc tggacgagat catcgagcag atcagcgagt tctccaagag agtgatcctg 4860
gccgacgcta atctggacaa agtgctgtcc gcctacaaca agcaccggga taagcccatc 4920
agagagcagg ccgagaatat catccacctg tttaccctga ccaatctggg agcccctgcc 4980
gccttcaagt actttgacac caccatcgac cggaagaggt acaccagcac caaagaggtg 5040
ctggacgcca ccctgatcca ccagagcatc accggcctgt acgagacacg gatcgacctg 5100
tctcagctgg gaggcgacaa gcgacctgcc gccacaaaga aggctggaca ggctaagaag 5160
aagaaagatt acaaagacga tgacgataag tgactcgagt aaggatccgc ccctctccct 5220
cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct 5280
atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc 5340
ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc 5400
tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg 5460
tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa 5520
agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt 5580
ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg 5640
atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta 5700
catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt 5760
tcctttgaaa aacacgatga taatatggcc acaaccatgg tgagcaaggg cgaggagctg 5820
ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc 5880
agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc 5940
tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc 6000
gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc 6060
atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag 6120
acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc 6180
atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc 6240
cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc 6300
cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc 6360
atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg 6420
agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc 6480
gggatcactc tcggcatgga cgagctgtac aagtaaagcg gccgcgactc tagatcataa 6540
tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 6600
tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 6660
atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 6720
attctagttg tggtttgtcc aaactcatca atgtatctta aatcgaattg gtcaggtggc 6780
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 6840
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 6900
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 6960
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 7020
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 7080
cccgaagaac gttctccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 7140
tcccgtgttg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 7200
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 7260
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 7320
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 7380
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 7440
atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 7500
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 7560
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 7620
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 7680
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 7740
gcctcactga ttaagcattg gtaactgtca gaccaagttt aattaacttt aaataatgcc 7800
aattatttaa agttaatccg cggagaagct tctcgaccaa ttctcatgtt tgacagctta 7860
tcatcgaatt tctgccattc atccgcttat tatcacttat tcaggcgtag caaccaggcg 7920
tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac tcatcgcagt 7980
actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg gcatgatgaa 8040
cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg cccatggtga 8100
aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg gtgaaactca 8160
cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg aaataggcca 8220
ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc cggaaatcgt 8280
cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa acggtgtaac 8340
aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata cggaattccg 8400
gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac ttgtgcttat 8460
ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg ttataggtac 8520
attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg gatatatcaa 8580
cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct gaaaatctcg 8640
ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag ttggaacctc 8700
ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc ccggtatcaa 8760
cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt atttattcgc 8820
gataagctca tggagcggcg taaccgtcgc acaggaagga cagagaaagc gcggatctgg 8880
gaagtgacgg acagaacggt caggacctgg attggggagg cggttgccgc cgctgctgct 8940
gacggtgtga cgttctctgt tccggtcaca ccacatacgt tccgccattc ctatgcgatg 9000
cacatgctgt atgccggtat accgctgaaa gttctgcaaa gcctgatggg acataagtcc 9060
atcagttcaa cggaagtcta cacgaaggtt tttgcgctgg atgtggctgc ccggcaccgg 9120
gtgcagtttg cgatgccgga gtctgatgcg gttgcgatgc tgaaacaatt atcctgagaa 9180
taaatgcctt ggcctttata tggaaatgtg gaactgagtg gatatgctgt ttttgtctgt 9240
taaacagaga agctggctgt tatccactga gaagcgaacg aaacagtcgg gaaaatctcc 9300
cattatcgta gagatccgca ttattaatct caggagcctg tgtagcgttt ataggaagta 9360
gtgttctgtc atgatgcctg caagcggtaa cgaaaacgat ttgaatatgc cttcaggaac 9420
aatagaaatc ttcgtgcggt gttacgttga agtggagcgg attatgtcag caatggacag 9480
aacaacctaa tgaacacaga accatgatgt ggtctgtcct tttacagcca gtaggctcgc 9540
cgcagtcgag cgacggcgaa gccctcgagt gagcgaggaa gcaccaggga acagcactta 9600
tatattctgc ttacacacga tgcctgaaaa aacttccctt ggggttatcc acttatccac 9660
ggggatattt ttataattat tttttttata gtttttagat cttctttttt agagcgcctt 9720
gtaggccttt atccatgctg gttctagaga aggtgttgtg acaaattgcc ctttcagtgt 9780
gacaaatcac cctcaaatga cagtcctgtc tgtgacaaat tgcccttaac cctgtgacaa 9840
attgccctca gaagaagctg ttttttcaca aagttatccc tgcttattga ctctttttta 9900
tttagtgtga caatctaaaa acttgtcaca cttcacatgg atctgtcatg gcggaaacag 9960
cggttatcaa tcacaagaaa cgtaaaaata gcccgcgaat cgtccagtca aacgacctca 10020
ctgaggcggc atatagtctc tcccgggatc aaaaacgtat gctgtatctg ttcgttgacc 10080
agatcagaaa atctgatggc accctacagg aacatgacgg tatctgcgag atccatgttg 10140
ctaaatatgc tgaaatattc ggattgacct ctgcggaagc cagtaaggat atacggcagg 10200
cattgaagag tttcgcgggg aaggaagtgg ttttttatcg ccctgaagag gatgccggcg 10260
atgaaaaagg ctatgaatct tttccttggt ttatcaaacg tgcgcacagt ccatccagag 10320
ggctttacag tgtacatatc aacccatatc tcattccctt ctttatcggg ttacagaacc 10380
ggtttacgca gtttcggctt agtgaaacaa aagaaatcac caatccgtat gccatgcgtt 10440
tatacgaatc cctgtgtcag tatcgtaagc cggatggctc aggcatcgtc tctctgaaaa 10500
tcgactggat catagagcgt taccagctgc ctcaaagtta ccagcgtatg cctgacttcc 10560
gccgccgctt cctgcaggtc tgtgttaatg agatcaacag cagaactcca atgcgcctct 10620
catacattga gaaaaagaaa ggccgccaga cgactcatat cgtattttcc ttccgcgata 10680
tcacttccat gacgacagga tagtctgagg gttatctgtc acagatttga gggtggttcg 10740
tcacatttgt tctgacctac tgagggtaat ttgtcacagt tttgctgttt ccttcagcct 10800
gcatggattt tctcatactt tttgaactgt aatttttaag gaagccaaat ttgagggcag 10860
tttgtcacag ttgatttcct tctctttccc ttcgtcatgt gacctgatat cgggggttag 10920
ttcgtcatca ttgatgaggg ttgattatca cagtttatta ctctgaattg gctatccgcg 10980
tgtgtacctc tacctggagt ttttcccacg gtggatattt cttcttgcgc tgagcgtaag 11040
agctatctga cagaacagtt cttctttgct tcctcgccag ttcgctcgct atgctcggtt 11100
acacggctgc ggcgagcgct agtgataata agtgactgag gtatgtgctc ttcttatctc 11160
cttttgtagt gttgctctta ttttaaacaa ctttgcggtt ttttgatgac tttgcgattt 11220
tgttgttgct ttgcagtaaa ttgcaagatt taataaaaaa acgcaaagca atgattaaag 11280
gatgttcaga atgaaactca tggaaacact taaccagtgc ataaacgctg gtcatgaaat 11340
gacgaaggct atcgccattg cacagtttaa tgatgacagc ccggaagcga ggaaaataac 11400
ccggcgctgg agaataggtg aagcagcgga tttagttggg gtttcttctc aggctatcag 11460
agatgccgag aaagcagggc gactaccgca cccggatatg gaaattcgag gacgggttga 11520
gcaacgtgtt ggttatacaa ttgaacaaat taatcatatg cgtgatgtgt ttggtacgcg 11580
attgcgacgt gctgaagacg tatttccacc ggtgatcggg gttgctgccc ataaaggtgg 11640
cgtttacaaa acctcagttt ctgttcatct tgctcaggat ctggctctga aggggctacg 11700
tgttttgctc gtggaaggta acgaccccca gggaacagcc tcaatgtatc acggatgggt 11760
accagatctt catattcatg cagaagacac tctcctgcct ttctatcttg gggaaaagga 11820
cgatgtcact tatgcaataa agcccacttg ctggccgggg cttgacatta ttccttcctg 11880
tctggctctg caccgtattg aaactgagtt aatgggcaaa tttgatgaag gtaaactgcc 11940
caccgatcca cacctgatgc tccgactggc cattgaaact gttgctcatg actatgatgt 12000
catagttatt gacagcgcgc ctaacctggg tatcggcacg attaatgtcg tatgtgctgc 12060
tgatgtgctg attgttccca cgcctgctga gttgtttgac tacacctccg cactgcagtt 12120
tttcgatatg cttcgtgatc tgctcaagaa cgttgatctt aaagggttcg agcctgatgt 12180
acgtattttg cttaccaaat acagcaatag taatggctct cagtccccgt ggatggagga 12240
gcaaattcgg gatgcctggg gaagcatggt tctaaaaaat gttgtacgtg aaacggatga 12300
agttggtaaa ggtcagatcc ggatgagaac tgtttttgaa caggccattg atcaacgctc 12360
ttcaactggt gcctggagaa atgctctttc tatttgggaa cctgtctgca atgaaatttt 12420
cgatcgtctg attaaaccac gctgggagat tagataatga agcgtgcgcc tgttattcca 12480
aaacatacgc tcaatactca accggttgaa gatacttcgt tatcgacacc agctgccccg 12540
atggtggatt cgttaattgc gcgcgtagga gtaatggctc gcggtaatgc cattactttg 12600
cctgtatgtg gtcgggatgt gaagtttact cttgaagtgc tccggggtga tagtgttgag 12660
aagacctctc gggtatggtc aggtaatgaa cgtgaccagg agctgcttac tgaggacgca 12720
ctggatgatc tcatcccttc ttttctactg actggtcaac agacaccggc gttcggtcga 12780
agagtatctg gtgtcataga aattgccgat gggagtcgcc gtcgtaaagc tgctgcactt 12840
accgaaagtg attatcgtgt tctggttggc gagctggatg atgagcagat ggctgcatta 12900
tccagattgg gtaacgatta tcgcccaaca agtgcttatg aacgtggtca gcgttatgca 12960
agccgattgc agaatgaatt tgctggaaat atttctgcgc tggctgatgc ggaaaatatt 13020
tcacgtaaga ttattacccg ctgtatcaac accgccaaat tgcctaaatc agttgttgct 13080
cttttttctc accccggtga actatctgcc cggtcaggtg atgcacttca aaaagccttt 13140
acagataaag aggaattact taagcagcag gcatctaacc ttcatgagca gaaaaaagct 13200
ggggtgatat ttgaagctga agaagttatc actcttttaa cttctgtgct taaaacgtca 13260
tctgcatcaa gaactagttt aagctcacga catcagtttg ctcctggagc gacagtattg 13320
tataagggcg ataaaatggt gcttaacctg gacaggtctc gtgttccaac tgagtgtata 13380
gagaaaattg aggccattct taaggaactt gaaaagccag caccctgatg cgaccacgtt 13440
ttagtctacg tttatctgtc tttacttaat gtcctttgtt acaggccaga aagcataact 13500
ggcctgaata ttctctctgg gcccactgtt ccacttgtat cgtcggtctg ataatcagac 13560
tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 13620
tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 13680
taatcagact gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 13740
tggtcccact cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg 13800
tcggtctgat tattagtctg gaaccacggt cccactcgta tcgtcggtct gattattagt 13860
ctgggaccac ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacgatccca 13920
ctcgtgttgt cggtctgatt atcggtctgg gaccacggtc ccacttgtat tgtcgatcag 13980
actatcagcg tgagactacg attccatcaa tgcctgtcaa gggcaagtat tgacatgtcg 14040
tcgtaacctg tagaacggag taacctcggt gtgcggttgt atgcctgctg tggattgctg 14100
ctgtgtcctg cttatccaca acattttgcg cacggttatg tggacaaaat acctggttac 14160
ccaggccgtg ccggcacgtt aaccgggctg catccgatgc aagtgtgtcg ctgtcgagtt 14220
ttcgggggag tccagggttt tcccagtcac gacgttgtaa aacgacggcc agtgaattcg 14280
agctcggtac ccggggatct tgaagttcct attctctaga aagtatagga acttcaattc 14340
ccatgtcagc cgttaagtgt tcctgtgtca ctcaaaattg ctttgagagg ctctaagggc 14400
ttctcagtgc gttacatccc tggcttgttg tccacaaccg ttaaacctta aaagctttaa 14460
aagccttata tattcttttt tttcttataa aacttaaaac cttagaggct atttaagttg 14520
ctgatttata ttaattttat tgttcaaaca tgagagctta gtacgtgaaa catgagagct 14580
tagtacgtta gccatgagag cttagtacgt tagccatgag ggtttagttc gttaaacatg 14640
agagcttagt acgttaaaca tgagagctta gtacgtgaaa catgagagct tagtacgtac 14700
tatcaacagg ttgaactgct gatcttcaga tcctctacgc cggacgcatc gtggccttaa 14760
ttaacatatg gatttattca acaaagccac gttgtgtctc aaaatctctg atgttacatt 14820
gcacaagata aaaatatatc atcatgaaca ataaaactgt ctgcttacat aaacagtaat 14880
acaaggggtg ttatgagcca tattcaacgg gaaacgtctt gctcgaggcc gcgattaaat 14940
tccaacatgg atgctgattt atatgggtat aaatgggctc gcgataatgt cgggcaatca 15000
ggtgcgacaa tctatcgatt gtatgggaag cccgatgcgc cagagttgtt tctgaaacat 15060
ggcaaaggta gcgttgccaa tgatgttaca gatgagatgg tcagactaaa ctggctgacg 15120
gaatttatgc ctcttccgac catcaagcat tttatccgta ctcctgatga tgcatggtta 15180
ctcaccactg cgatccccgg gaaaacagca ttccaggtat tagaagaata tcctgattca 15240
ggtgaaaata ttgttgatgc gctggcagtg ttcctgcgcc ggttgcattc gattcctgtt 15300
tgtaattgtc cttttaacag cgatcgcgta tttcgtctcg ctcaggcgca atcacgaatg 15360
aataacggtt tggttgatgc gagtgatttt gatgacgagc gtaatggctg gcctgttgaa 15420
caagtctgga aagaaatgca taagcttttg ccattctcac cggattcagt cgtcactcat 15480
ggtgatttct cacttgataa ccttattttt gacgagggga aattaatagg ttgtattgat 15540
gttggacgag tcggaatcgc agaccgatac caggatcttg ccatcctatg gaactgcctc 15600
ggtgagtttt ctccttcatt acagaaacgg ctttttcaaa aatatggtat tgataatcct 15660
gatatgaata aattgcagtt tcatttgatg ctcgatgagt ttttctaatc agaattggtt 15720
aattggttgt aacactgggc atgctaattg cagtggaccc cggaggcatc atcaataata 15780
taccttattt tggattgaag ccaatatgat aatgaggggg tggagtttgt gacgtggcgc 15840
ggggcgtggg aacggggcgg gtgacgtagt agtgtggcgg aagtgtgatg ttgcaagtgt 15900
ggcggaacac atgtaagcga cggatgtggc aaaagtgacg tttttggtgt gcgccggtgt 15960
acacaggaag tgacaatttt cgcgcggttt taggcggatg ttgtagtaaa tttgggcgta 16020
accgagtaag atttggccat tttcgcggga aaactgaata agaggaagtg aaatctgaat 16080
aattttgtgt tactcatagc gcgtaataat agtaatcaat tacggggtca ttagttcata 16140
gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 16200
ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 16260
ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 16320
atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg 16380
cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg 16440
tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat 16500
agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 16560
tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc 16620
aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctggt ttagtgaacc 16680
gtcagatccg ctagcgctac cggactcaga tctcgagctc aagcttcgaa ttctgcagtc 16740
gacggtaccg agctcggatc ccgccaccat ggtgagcaag ggcgaggagg ataacatggc 16800
catcatcaag gagttcatgc gcttcaaggt gcacatggag ggctccgtga acggccacga 16860
gttcgagatc gagggcgagg gcgagggccg cccctacgag ggcacccaga ccgccaagct 16920
gaaggtgacc aagggtggcc ccctgccctt cgcctgggac atcctgtccc ctcagttcat 16980
gtacggctcc aaggcctacg tgaagcaccc cgccgacatc cccgactact tgaagctgtc 17040
cttccccgag ggcttcaagt gggagcgcgt gatgaacttc gaggacggcg gcgtggtgac 17100
cgtgacccag gactcctccc tgcaggacgg cgagttcatc tacaaggtga agctgcgcgg 17160
caccaacttc ccctccgacg gccccgtaat gcagaagaag accatgggct gggaggcctc 17220
ctccgagcgg atgtaccccg aggacggcgc cctgaagggc gagatcaagc agaggctgaa 17280
gctgaaggac ggcggccact acgacgctga ggtcaagacc acctacaagg ccaagaagcc 17340
cgtgcagctg cccggcgcct acaacgtcaa catcaagttg gacatcacct cccacaacga 17400
ggactacacc atcgtggaac agtacgaacg cgccgagggc cgccactcca ccggcggcat 17460
ggacgagctg tacaagtaag aattctgcag atatccagca cagtggcggc cgcgactcta 17520
gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 17580
cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 17640
agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 17700
ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttaaa tcgaattcaa 17760
gcttgtcgac tcgaagatct gagctcacgc gtgaagttcc tattccgaag ttcctattct 17820
ctagaaagta taggaacttc agagcgcttt tgaagctggg gtgggcgaag aactccagca 17880
tgagatcccc agagcgcttt tgaagctgcg tttaaacgcg atatcccggg agctcccgat 17940
atcgcgttta aacgcagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt 18000
tatccgctca caattccaca caacatacga gccggaagac tgaaatgtgt gggcgtggct 18060
taagggtggg aaagaatata taaggtgggg gtcttatgta gttttgtatc tgttttgcag 18120
cagccgccgc cgccatgagc accaactcgt ttgatggaag cattgtgagc tcatatttga 18180
caacgcgcat gcccccatgg gccggggtgc gtcagaatgt gatgggctcc agcattgatg 18240
gtcgccccgt cctgcccgca aactctacta ccttgaccta cgagaccgtg tctggaacgc 18300
cgttggagac tgcagcctcc gccgccgctt cagccgctgc agccaccgcc cgcgggattg 18360
tgactgactt tgctttcctg agcccgcttg caagcagtgc agcttcccgt tcatccgccc 18420
gcgatgacaa gttgacggct cttttggcac aattggattc tttgacccgg gaacttaatg 18480
tcgtttctca gcagctgttg gatctgcgcc agcaggtttc tgccctgaag gcttcctccc 18540
ctcccaatgc ggtttaaaac ataaataaaa aaccagactc tgtttggatt tggatcaagc 18600
aagtgtcttg ctgtctttat ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt 18660
ctcggtcgtt gagggtcctg tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt 18720
tcagatacat gggcataagc ccgtctctgg ggtggaggta gcaccactgc agagcttcat 18780
gctgcggggt ggtgttgtag atgatccagt cgtagcagga gcgctgggcg tggtgcctaa 18840
aaatgtcttt cagtagcaag ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa 18900
agcggttaag ctgggatggg tgcatacgtg gggatatgag atgcatcttg gactgtattt 18960
ttaggttggc tatgttccca gccatatccc tccggggatt catgttgtgc agaaccacca 19020
gcacagtgta tccggtgcac ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga 19080
agaacttgga gacgcccttg tgacctccaa gattttccat gcattcgtcc ataatgatgg 19140
caatgggccc acgggcggcg gcctgggcga agatatttct gggatcacta acgtcatagt 19200
tgtgttccag gatgagatcg tcataggcca tttttacaaa gcgcgggcgg agggtgccag 19260
actgcggtat aatggttcca tccggcccag gggcgtagtt accctcacag atttgcattt 19320
cccacgcttt gagttcagat ggggggatca tgtctacctg cggggcgatg aagaaaacgg 19380
tttccggggt aggggagatc agctgggaag aaagcaggtt cctgagcagc tgcgacttac 19440
cgcagccggt gggcccgtaa atcacaccta ttaccgggtg caactggtag ttaagagagc 19500
tgcagctgcc gtcatccctg agcagggggg ccacttcgtt aagcatgtcc ctgactcgca 19560
tgttttccct gaccaaatcc gccagaaggc gctcgccgcc cagcgatagc agttcttgca 19620
aggaagcaaa gtttttcaac ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt 19680
gaccaagcag ttccaggcgg tcccacagct cggtcacctg ctctacggca tctcgatcca 19740
gcatatctcc tcgtttcgcg ggttggggcg gctttcgctg tacggcagta gtcggtgctc 19800
gtccagacgg gccagggtca tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg 19860
ggtcacggtg aaggggtgcg ctccgggctg cgcgctggcc agggtgcgct tgaggctggt 19920
cctgctggtg ctgaagcgct gccggtcttc gccctgcgcg tcggccaggt agcatttgac 19980
catggtgtca tagtccagcc cctccgcggc gtggcccttg gcgcgcagct tgcccttgga 20040
ggaggcgccg cacgaggggc agtgcagact tttgagggcg tagagcttgg gcgcgagaaa 20100
taccgattcc ggggagtagg catccgcgcc gcaggccccg cagacggtct cgcattccac 20160
gagccaggtg agctctggcc gttcggggtc aaaaaccagg tttcccccat gctttttgat 20220
gcgtttctta cctctggttt ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc 20280
cgtgtccccg tatacagact tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc 20340
gtatagaaac tcggaccact ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc 20400
taagtgggag gggtagcggt cgttgtccac tagggggtcc actcgctcca gggtgtgaag 20460
acacatgtcg ccctcttcgg catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg 20520
accgggtgtt cctgaagggg ggctataaaa gggggtgggg gcgcgttcgt cctcactctc 20580
ttccgcatcg ctgtctgcga gggccagctg ttggggtgag tactccctct gaaaagcggg 20640
catgacttct gcgctaagat tgtcagtttc caaaaacgag gaggatttga tattcacctg 20700
gcccgcggtg atgcctttga gggtggccgc atccatctgg tcagaaaaga caatcttttt 20760
gttgtcaagc ttggtggcaa acgacccgta gagggcgttg gacagcaact tggcgatgga 20820
gcgcagggtt tggtttttgt cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac 20880
gtattcgcgc gcaacgcacc gccattcggg aaagacggtg gtgcgctcgt cgggcaccag 20940
gtgcacgcgc caaccgcggt tgtgcagggt gacaaggtca acgctggtgg ctacctctcc 21000
gcgtaggcgc tcgttggtcc agcagaggcg gccgcccttg cgcgagcaga atggcggtag 21060
ggggtctagc tgcgtctcgt ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag 21120
gcgcgcgtcg aagtagtcta tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg 21180
ggcggcaagc gcgcgctcgt atgggttgag tgggggaccc catggcatgg ggtgggtgag 21240
cgcggaggcg tacatgccgc aaatgtcgta aacgtagagg ggctctctga gtattccaag 21300
atatgtaggg tagcatcttc caccgcggat gctggcgcgc acgtaatcgt atagttcgtg 21360
cgagggagcg aggaggtcgg gaccgaggtt gctacgggcg ggctgctctg ctcggaagac 21420
tatctgcctg aagatggcat gtgagttgga tgatatggtt ggacgctgga agacgttgaa 21480
gctggcgtct gtgagaccta ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt 21540
gttgaccagc tcggcggtga cctgcacgtc tagggcgcag tagtccaggg tttccttgat 21600
gatgtcatac ttatcctgtc cctttttttt ccacagctcg cggttgagga caaactcttc 21660
gcggtctttc cagtactctt ggatcggaaa cccgtcggcc tccgaacggt aagagcctag 21720
catgtagaac tggttgacgg cctggtaggc gcagcatccc ttttctacgg gtagcgcgta 21780
tgcctgcgcg gccttccgga gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac 21840
tttgaggtac tggtatttga agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa 21900
gtccgtgcgc tttttggaac gcggatttgg cagggcgaag gtgacatcgt tgaagagtat 21960
ctttcccgcg cgaggcataa agttgcgtgt gatgcggaag ggtcccggca cctcggaacg 22020
gttgttaatt acctgggcgg cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac 22080
aatgtaaagt tccaagaagc gcgggatgcc cttgatggaa ggcaattttt taagttcctc 22140
gtaggtgagc tcttcagggg agctgagccc gtgctctgaa agggcccagt ctgcaagatg 22200
agggttggaa gcgacgaatg agctccacag gtcacgggcc attagcattt gcaggtggtc 22260
gcgaaaggtc ctaaactggc gacctatggc cattttttct ggggtgatgc agtagaaggt 22320
aagcgggtct tgttcccagc ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt 22380
cactagaggc tcatctccgc cgaacttcat gaccagcatg aagggcacga gctgcttccc 22440
aaaggccccc atccaagtat aggtctctac atcgtaggtg acaaagagac gctcggtgcg 22500
aggatgcgag ccgatcggga agaactggat ctcccgccac caattggagg agtggctatt 22560
gatgtggtga aagtagaagt ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa 22620
acgtgcgcag tactggcagc ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg 22680
accgcgcaca aggaagcaga gtgggaattt gagcccctcg cctggcgggt ttggctggtg 22740
gtcttctact tcggctgctt gtccttgacc gtctggctgc tcgaggggag ttacggtgga 22800
tcggaccacc acgccgcgcg agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt 22860
gatgacaaca tcgcgcagat gggagctgtc catggtctgg agctcccgcg gcgtcaggtc 22920
aggcgggagc tcctgcaggt ttacctcgca tagacgggtc agggcgcggg ctagatccag 22980
gtgataccta atttccaggg gctggttggt ggcggcgtcg atggcttgca agaggccgca 23040
tccccgcggc gcgactacgg taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga 23100
tgatgcatct aaaagcggtg acgcgggcga gcccccggag gtaggggggg ctccggaccc 23160
gccgggagag ggggcagggg cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg 23220
cgtaggttgc tggcgaacgc gacgacgcgg cggttgatct cctgaatctg gcgcctctgc 23280
gtgaagacga cgggcccggt gagcttgagc ctgaaagaga gttcgacaga atcaatttcg 23340
gtgtcgttga cggcggcctg gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag 23400
gcgatctcgg ccatgaactg ctcgatctct tcctcctgga gatctccgcg tccggctcgc 23460
tccacggtgg cggcgaggtc gttggaaatg cgggccatga gctgcgagaa ggcgttgagg 23520
cctccctcgt tccagacgcg gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg 23580
accacctgcg cgagattgag ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc 23640
tgaaagaggt agttgagggt ggtggcggtg tgttctgcca cgaagaagta cataacccag 23700
cgtcgcaacg tggattcgtt gatatccccc aaggcctcaa ggcgctccat ggcctcgtag 23760
aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg acacggttaa ctcctcctcc 23820
agaagacgga tgagctcggc gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc 23880
tcttcttctt cttcaatctc ctcttccata agggcctccc cttcttcttc ttctggcggc 23940
ggtgggggag gggggacacg gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc 24000
tcgatcatct ccccgcggcg acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg 24060
gggcgcagtt ggaagacgcc gcccgtcatg tcccggttat gggttggcgg ggggctgcca 24120
tgcggcaggg atacggcgct aacgatgcat ctcaacaatt gttgtgtagg tactccgccg 24180
ccgagggacc tgagcgagtc cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct 24240
aaccagtcac agtcgcaagg taggctgagc accgtggcgg gcggcagcgg gcggcggtcg 24300
gggttgtttc tggcggaggt gctgctgatg atgtaattaa agtaggcggt cttgagacgg 24360
cggatggtcg acagaagcac catgtccttg ggtccggcct gctgaatgcg caggcggtcg 24420
gccatgcccc aggcttcgtt ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc 24480
ctttctaccg gcacttcttc ttctccttcc tcttgtcctg catctcttgc atctatcgct 24540
gcggcggcgg cggagtttgg ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg 24600
aagcccctca tcggctgaag cagggctagg tcggcgacaa cgcgctcggc taatatggcc 24660
tgctgcacct gcgtgagggt agactggaag tcatccatgt ccacaaagcg gtggtatgcg 24720
cccgtgttga tggtgtaagt gcagttggcc ataacggacc agttaacggt ctggtgaccc 24780
ggctgcgaga gctcggtgta cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg 24840
ttgcaagtcc gcaccaggta ctggtatccc accaaaaagt gcggcggcgg ctggcggtag 24900
aggggccagc gtagggtggc cggggctccg ggggcgagat cttccaacat aaggcgatga 24960
tatccgtaga tgtacctgga catccaggtg atgccggcgg cggtggtgga ggcgcgcgga 25020
aagtcgcgga cgcggttcca gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg 25080
ctctggccgg tcaggcgcgc gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg 25140
taagcgggca ctcttccgtg gtctggtgga taaattcgca agggtatcat ggcggacgac 25200
cggggttcga gccccgtatc cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt 25260
cgaacccagg tgtgcgacgt cagacaacgg gggagtgctc cttttggctt ccttccaggc 25320
gcggcggctg ctgcgctagc ttttttggcc actggccgcg cgcagcgtaa gcggttaggc 25380
tggaaagcga aagcattaag tggctcgctc cctgtagccg gagggttatt ttccaagggt 25440
tgagtcgcgg gacccccggt tcgagtctcg gaccggccgg actgcggcga acgggggttt 25500
gcctccccgt catgcaagac cccgcttgca aattcctccg gaaacaggga cgagcccctt 25560
ttttgctttt cccagatgca tccggtgctg cggcagatgc gcccccctcc tcagcagcgg 25620
caagagcaag agcagcggca gacatgcagg gcaccctccc ctcctcctac cgcgtcagga 25680
ggggcgacat ccgcggttga cgcggcagca gatggtgatt acgaaccccc gcggcgccgg 25740
gcccggcact acctggactt ggaggagggc gagggcctgg cgcggctagg agcgccctct 25800
cctgagcggt acccaagggt gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg 25860
cagaacctgt ttcgcgaccg cgagggagag gagcccgagg agatgcggga tcgaaagttc 25920
cacgcagggc gcgagctgcg gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac 25980
tttgagcccg acgcgcgaac cgggattagt cccgcgcgcg cacacgtggc ggccgccgac 26040
ctggtaaccg catacgagca gacggtgaac caggagatta actttcaaaa aagctttaac 26100
aaccacgtgc gtacgcttgt ggcgcgcgag gaggtggcta taggactgat gcatctgtgg 26160
gactttgtaa gcgcgctgga gcaaaaccca aatagcaagc cgctcatggc gcagctgttc 26220
cttatagtgc agcacagcag ggacaacgag gcattcaggg atgcgctgct aaacatagta 26280
gagcccgagg gccgctggct gctcgatttg ataaacatcc tgcagagcat agtggtgcag 26340
gagcgcagct tgagcctggc tgacaaggtg gccgccatca actattccat gcttagcctg 26400
ggcaagtttt acgcccgcaa gatataccat accccttacg ttcccataga caaggaggta 26460
aagatcgagg ggttctacat gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg 26520
ggcgtttatc gcaacgagcg catccacaag gccgtgagcg tgagccggcg gcgcgagctc 26580
agcgaccgcg agctgatgca cagcctgcaa agggccctgg ctggcacggg cagcggcgat 26640
agagaggccg agtcctactt tgacgcgggc gctgacctgc gctgggcccc aagccgacgc 26700
gccctggagg cagctggggc cggacctggg ctggcggtgg cacccgcgcg cgctggcaac 26760
gtcggcggcg tggaggaata tgacgaggac gatgagtacg agccagagga cggcgagtac 26820
taagcggtga tgtttctgat cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg 26880
cgctgcagag ccagccgtcc ggccttaact ccacggacga ctggcgccag gtcatggacc 26940
gcatcatgtc gctgactgcg cgcaatcctg acgcgttccg gcagcagccg caggccaacc 27000
ggctctccgc aattctggaa gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg 27060
tgctggcgat cgtaaacgcg ctggccgaaa acagggccat ccggcccgac gaggccggcc 27120
tggtctacga cgcgctgctt cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca 27180
acctggaccg gctggtgggg gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc 27240
agcagggcaa cctgggctcc atggttgcac taaacgcctt cctgagtaca cagcccgcca 27300
acgtgccgcg gggacaggag gactacacca actttgtgag cgcactgcgg ctaatggtga 27360
ctgagacacc gcaaagtgag gtgtaccagt ctgggccaga ctattttttc cagaccagta 27420
gacaaggcct gcagaccgta aacctgagcc aggctttcaa aaacttgcag gggctgtggg 27480
gggtgcgggc tcccacaggc gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc 27540
gcctgttgct gctgctaata gcgcccttca cggacagtgg cagcgtgtcc cgggacacat 27600
acctaggtca cttgctgaca ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc 27660
atactttcca ggagattaca agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc 27720
tggaggcaac cctaaactac ctgctgacca accggcggca gaagatcccc tcgttgcaca 27780
gtttaaacag cgaggaggag cgcattttgc gctacgtgca gcagagcgtg agccttaacc 27840
tgatgcgcga cggggtaacg cccagcgtgg cgctggacat gaccgcgcgc aacatggaac 27900
cgggcatgta tgcctcaaac cggccgttta tcaaccgcct aatggactac ttgcatcgcg 27960
cggccgccgt gaaccccgag tatttcacca atgccatctt gaacccgcac tggctaccgc 28020
cccctggttt ctacaccggg ggattcgagg tgcccgaggg taacgatgga ttcctctggg 28080
acgacataga cgacagcgtg ttttccccgc aaccgcagac cctgctagag ttgcaacagc 28140
gcgagcaggc agaggcggcg ctgcgaaagg aaagcttccg caggccaagc agcttgtccg 28200
atctaggcgc tgcggccccg cggtcagatg ctagtagccc atttccaagc ttgatagggt 28260
ctcttaccag cactcgcacc acccgcccgc gcctgctggg cgaggaggag tacctaaaca 28320
actcgctgct gcagccgcag cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga 28380
tagagagcct agtggacaag atgagtagat ggaagacgta cgcgcaggag cacagggacg 28440
tgccaggccc gcgcccgccc acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt 28500
gggaggacga tgactcggca gacgacagca gcgtcctgga tttgggaggg agtggcaacc 28560
cgtttgcgca ccttcgcccc aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc 28620
aaaataaaaa actcaccaag gccatggcac cgagcgttgg ttttcttgta ttccccttag 28680
tatgcggcgc gcggcgatgt atgaggaagg tcctcctccc tcctacgaga gtgtggtgag 28740
cgcggcgcca gtggcggcgg cgctgggttc tcccttcgat gctcccctgg acccgccgtt 28800
tgtgcctccg cggtacctgc ggcctaccgg ggggagaaac agcatccgtt actctgagtt 28860
ggcaccccta ttcgacacca cccgtgtgta cctggtggac aacaagtcaa cggatgtggc 28920
atccctgaac taccagaacg accacagcaa ctttctgacc acggtcattc aaaacaatga 28980
ctacagcccg ggggaggcaa gcacacagac catcaatctt gacgaccggt cgcactgggg 29040
cggcgacctg aaaaccatcc tgcataccaa catgccaaat gtgaacgagt tcatgtttac 29100
caataagttt aaggcgcggg tgatggtgtc gcgcttgcct actaaggaca atcaggtgga 29160
gctgaaatac gagtgggtgg agttcacgct gcccgagggc aactactccg agaccatgac 29220
catagacctt atgaacaacg cgatcgtgga gcactacttg aaagtgggca gacagaacgg 29280
ggttctggaa agcgacatcg gggtaaagtt tgacacccgc aacttcagac tggggtttga 29340
ccccgtcact ggtcttgtca tgcctggggt atatacaaac gaagccttcc atccagacat 29400
cattttgctg ccaggatgcg gggtggactt cacccacagc cgcctgagca acttgttggg 29460
catccgcaag cggcaaccct tccaggaggg ctttaggatc acctacgatg atctggaggg 29520
tggtaacatt cccgcactgt tggatgtgga cgcctaccag gcgagcttga aagatgacac 29580
cgaacagggc gggggtggcg caggcggcag caacagcagt ggcagcggcg cggaagagaa 29640
ctccaacgcg gcagccgcgg caatgcagcc ggtggaggac atgaacgatc atgccattcg 29700
cggcgacacc tttgccacac gggctgagga gaagcgcgct gaggccgaag cagcggccga 29760
agctgccgcc cccgctgcgc aacccgaggt cgagaagcct cagaagaaac cggtgatcaa 29820
acccctgaca gaggacagca agaaacgcag ttacaaccta ataagcaatg acagcacctt 29880
cacccagtac cgcagctggt accttgcata caactacggc gaccctcaga ccggaatccg 29940
ctcatggacc ctgctttgca ctcctgacgt aacctgcggc tcggagcagg tctactggtc 30000
gttgccagac atgatgcaag accccgtgac cttccgctcc acgcgccaga tcagcaactt 30060
tccggtggtg ggcgccgagc tgttgcccgt gcactccaag agcttctaca acgaccaggc 30120
cgtctactcc caactcatcc gccagtttac ctctctgacc cacgtgttca atcgctttcc 30180
cgagaaccag attttggcgc gcccgccagc ccccaccatc accaccgtca gtgaaaacgt 30240
tcctgctctc acagatcacg ggacgctacc gctgcgcaac agcatcggag gagtccagcg 30300
agtgaccatt actgacgcca gacgccgcac ctgcccctac gtttacaagg ccctgggcat 30360
agtctcgccg cgcgtcctat cgagccgcac tttttgagca agcatgtcca tccttatatc 30420
gcccagcaat aacacaggct ggggcctgcg cttcccaagc aagatgtttg gcggggccaa 30480
gaagcgctcc gaccaacacc cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc 30540
gcacaaacgc ggccgcactg ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga 30600
ggaggcgcgc aactacacgc ccacgccgcc accagtgtcc acagtggacg cggccattca 30660
gaccgtggtg cgcggagccc ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc 30720
acgtcgccac cgccgccgac ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa 30780
ccgcgcacgt cgcaccggcc gacgggcggc catgcgggcc gctcgaaggc tggccgcggg 30840
tattgtcact gtgcccccca ggtccaggcg acgagcggcc gccgcagcag ccgcggccat 30900
tagtgctatg actcagggtc gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg 30960
cctgcgcgtg cccgtgcgca cccgcccccc gcgcaactag attgcaagaa aaaactactt 31020
agactcgtac tgttgtatgt atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg 31080
caaaatcaaa gaagagatgc tccaggtcat cgcgccggag atctatggcc ccccgaagaa 31140
ggaagagcag gattacaagc cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga 31200
tgatgatgaa cttgacgacg aggtggaact gctgcacgct accgcgccca ggcgacgggt 31260
acagtggaaa ggtcgacgcg taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac 31320
gcccggtgag cgctccaccc gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga 31380
ggacctgctt gagcaggcca acgagcgcct cggggagttt gcctacggaa agcggcataa 31440
ggacatgctg gcgttgccgc tggacgaggg caacccaaca cctagcctaa agcccgtaac 31500
actgcagcag gtgctgcccg cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga 31560
gtctggtgac ttggcaccca ccgtgcagct gatggtaccc aagcgccagc gactggaaga 31620
tgtcttggaa aaaatgaccg tggaacctgg gctggagccc gaggtccgcg tgcggccaat 31680
caagcaggtg gcgccgggac tgggcgtgca gaccgtggac gttcagatac ccactaccag 31740
tagcaccagt attgccaccg ccacagaggg catggagaca caaacgtccc cggttgcctc 31800
agcggtggcg gatgccgcgg tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga 31860
ggtgcaaacg gacccgtgga tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag 31920
gaagtacggc gccgccagcg cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc 31980
tacccccggc tatcgtggct acacctaccg ccccagaaga cgagcaacta cccgacgccg 32040
aaccaccact ggaacccgcc gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc 32100
cgtgcgcagg gtggctcgcg aaggaggcag gaccctggtg ctgccaacag cgcgctacca 32160
ccccagcatc gtttaaaagc cggtctttgt ggttcttgca gatatggccc tcacctgccg 32220
cctccgtttc ccggtgccgg gattccgagg aagaatgcac cgtaggaggg gcatggccgg 32280
ccacggcctg acgggcggca tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg 32340
tcgcatgcgc ggcggtatcc tgcccctcct tattccactg atcgccgcgg cgattggcgc 32400
cgtgcccgga attgcatccg tggccttgca ggcgcagaga cactgattaa aaacaagttg 32460
catgtggaaa aatcaaaata aaaagtctgg actctcacgc tcgcttggtc ctgtaactat 32520
tttgtagaat ggaagacatc aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt 32580
tcatgggaaa ctggcaagat atcggcacca gcaatatgag cggtggcgcc ttcagctggg 32640
gctcgctgtg gagcggcatt aaaaatttcg gttccaccgt taagaactat ggcagcaagg 32700
cctggaacag cagcacaggc cagatgctga gggataagtt gaaagagcaa aatttccaac 32760
aaaaggtggt agatggcctg gcctctggca ttagcggggt ggtggacctg gccaaccagg 32820
cagtgcaaaa taagattaac agtaagcttg atccccgccc tcccgtagag gagcctccac 32880
cggccgtgga gacagtgtct ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg 32940
aagaaactct ggtgacgcaa atagacgagc ctccctcgta cgaggaggca ctaaagcaag 33000
gcctgcccac cacccgtccc atcgcgccca tggctaccgg agtgctgggc cagcacacac 33060
ccgtaacgct ggacctgcct ccccccgccg acacccagca gaaacctgtg ctgccaggcc 33120
cgaccgccgt tgttgtaacc cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc 33180
cgcgatcgtt gcggcccgta gccagtggca actggcaaag cacactgaac agcatcgtgg 33240
gtctgggggt gcaatccctg aagcgccgac gatgcttctg aatagctaac gtgtcgtatg 33300
tgtgtcatgt atgcgtccat gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct 33360
ttccaagatg gctacccctt cgatgatgcc gcagtggtct tacatgcaca tctcgggcca 33420
ggacgcctcg gagtacctga gccccgggct ggtgcagttt gcccgcgcca ccgagacgta 33480
cttcagcctg aataacaagt ttagaaaccc cacggtggcg cctacgcacg acgtgaccac 33540
agaccggtcc cagcgtttga cgctgcggtt catccctgtg gaccgtgagg atactgcgta 33600
ctcgtacaag gcgcggttca ccctagctgt gggtgataac cgtgtgctgg acatggcttc 33660
cacgtacttt gacatccgcg gcgtgctgga caggggccct acttttaagc cctactctgg 33720
cactgcctac aacgccctgg ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc 33780
tgctactgct cttgaaataa acctagaaga agaggacgat gacaacgaag acgaagtaga 33840
cgagcaagct gagcagcaaa aaactcacgt atttgggcag gcgccttatt ctggtataaa 33900
tattacaaag gagggtattc aaataggtgt cgaaggtcaa acacctaaat atgccgataa 33960
aacatttcaa cctgaacctc aaataggaga atctcagtgg tacgaaactg aaattaatca 34020
tgcagctggg agagtcctta aaaagactac cccaatgaaa ccatgttacg gttcatatgc 34080
aaaacccaca aatgaaaatg gagggcaagg cattcttgta aagcaacaaa atggaaagct 34140
agaaagtcaa gtggaaatgc aatttttctc aactactgag gcgaccgcag gcaatggtga 34200
taacttgact cctaaagtgg tattgtacag tgaagatgta gatatagaaa ccccagacac 34260
tcatatttct tacatgccca ctattaagga aggtaactca cgagaactaa tgggccaaca 34320
atctatgccc aacaggccta attacattgc ttttagggac aattttattg gtctaatgta 34380
ttacaacagc acgggtaata tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt 34440
tgtagatttg caagacagaa acacagagct ttcataccag cttttgcttg attccattgg 34500
tgatagaacc aggtactttt ctatgtggaa tcaggctgtt gacagctatg atccagatgt 34560
tagaattatt gaaaatcatg gaactgaaga tgaacttcca aattactgct ttccactggg 34620
aggtgtgatt aatacagaga ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg 34680
atgggaaaaa gatgctacag aattttcaga taaaaatgaa ataagagttg gaaataattt 34740
tgccatggaa atcaatctaa atgccaacct gtggagaaat ttcctgtact ccaacatagc 34800
gctgtatttg cccgacaagc taaagtacag tccttccaac gtaaaaattt ctgataaccc 34860
aaacacctac gactacatga acaagcgagt ggtggctccc gggttagtgg actgctacat 34920
taaccttgga gcacgctggt cccttgacta tatggacaac gtcaacccat ttaaccacca 34980
ccgcaatgct ggcctgcgct accgctcaat gttgctgggc aatggtcgct atgtgccctt 35040
ccacatccag gtgcctcaga agttctttgc cattaaaaac ctccttctcc tgccgggctc 35100
atacacctac gagtggaact tcaggaagga tgttaacatg gttctgcaga gctccctagg 35160
aaatgaccta agggttgacg gagccagcat taagtttgat agcatttgcc tttacgccac 35220
cttcttcccc atggcccaca acaccgcctc cacgcttgag gccatgctta gaaacgacac 35280
caacgaccag tcctttaacg actatctctc cgccgccaac atgctctacc ctatacccgc 35340
caacgctacc aacgtgccca tatccatccc ctcccgcaac tgggcggctt tccgcggctg 35400
ggccttcacg cgccttaaga ctaaggaaac cccatcactg ggctcgggct acgaccctta 35460
ttacacctac tctggctcta taccctacct agatggaacc ttttacctca accacacctt 35520
taagaaggtg gccattacct ttgactcttc tgtcagctgg cctggcaatg accgcctgct 35580
tacccccaac gagtttgaaa ttaagcgctc agttgacggg gagggttaca acgttgccca 35640
gtgtaacatg accaaagact ggttcctggt acaaatgcta gctaactaca acattggcta 35700
ccagggcttc tatatcccag agagctacaa ggaccgcatg tactccttct ttagaaactt 35760
ccagcccatg agccgtcagg tggtggatga tactaaatac aaggactacc aacaggtggg 35820
catcctacac caacacaaca actctggatt tgttggctac cttgccccca ccatgcgcga 35880
aggacaggcc taccctgcta acttccccta tccgcttata ggcaagaccg cagttgacag 35940
cattacccag aaaaagtttc tttgcgatcg caccctttgg cgcatcccat tctccagtaa 36000
ctttatgtcc atgggcgcac tcacagacct gggccaaaac cttctctacg ccaactccgc 36060
ccacgcgcta gacatgactt ttgaggtgga tcccatggac gagcccaccc ttctttatgt 36120
tttgtttgaa gtctttgacg tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac 36180
cgtgtacctg cgcacgccct tctcggccgg caacgccaca acataaagaa gcaagcaaca 36240
tcaacaacag ctgccgccat gggctccagt gagcaggaac tgaaagccat tgtcaaagat 36300
cttggttgtg ggccatattt tttgggcacc tatgacaagc gctttccagg ctttgtttct 36360
ccacacaagc tcgcctgcgc catagtcaat acggccggtc gcgagactgg gggcgtacac 36420
tggatggcct ttgcctggaa cccgcactca aaaacatgct acctctttga gccctttggc 36480
ttttctgacc agcgactcaa gcaggtttac cagtttgagt acgagtcact cctgcgccgt 36540
agcgccattg cttcttcccc cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta 36600
caggggccca actcggccgc ctgtggacta ttctgctgca tgtttctcca cgcctttgcc 36660
aactggcccc aaactcccat ggatcacaac cccaccatga accttattac cggggtaccc 36720
aactccatgc tcaacagtcc ccaggtacag cccaccctgc gtcgcaacca ggaacagctc 36780
tacagcttcc tggagcgcca ctcgccctac ttccgcagcc acagtgcgca gattaggagc 36840
gccacttctt tttgtcactt gaaaaacatg taaaaataat gtactagaga cactttcaat 36900
aaaggcaaat gcttttattt gtacactctc gggtgattat ttacccccac ccttgccgtc 36960
tgcgccgttt aaaaatcaaa ggggttctgc cgcgcatcgc tatgcgccac tggcagggac 37020
acgttgcgat actggtgttt agtgctccac ttaaactcag gcacaaccat ccgcggcagc 37080
tcggtgaagt tttcactcca caggctgcgc accatcacca acgcgtttag caggtcgggc 37140
gccgatatct tgaagtcgca gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca 37200
gggttgcagc actggaacac tatcagcgcc gggtggtgca cgctggccag cacgctcttg 37260
tcggagatca gatccgcgtc caggtcctcc gcgttgctca gggcgaacgg agtcaacttt 37320
ggtagctgcc ttcccaaaaa gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt 37380
ggcatcaaaa ggtgaccgtg cccggtctgg gcgttaggat acagcgcctg cataaaagcc 37440
ttgatctgct taaaagccac ctgagccttt gcgccttcag agaagaacat gccgcaagac 37500
ttgccggaaa actgattggc cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg 37560
ttggagatct gcaccacatt tcggccccac cggttcttca cgatcttggc cttgctagac 37620
tgctccttca gcgcgcgctg cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc 37680
ttatttatca taatgcttcc gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg 37740
tgcagccaca acgcgcagcc cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac 37800
tgcaggtacg cctgcaggaa tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag 37860
gtcagctgca acccgcggtg ctcctcgttc agccaggtct tgcatacggc cgccagagct 37920
tccacttggt caggcagtag tttgaagttc gcctttagat cgttatccac gtggtacttg 37980
tccatcagcg cgcgcgcagc ctccatgccc ttctcccacg cagacacgat cggcacactc 38040
agcgggttca tcaccgtaat ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc 38100
gtccgcatac cacgcgccac tgggtcgtct tcattcagcc gccgcactgt gcgcttacct 38160
cctttgccat gcttgattag caccggtggg ttgctgaaac ccaccatttg tagcgccaca 38220
tcttctcttt cttcctcgct gtccacgatt acctctggtg atggcgggcg ctcgggcttg 38280
ggagaagggc gcttcttttt cttcttgggc gcaatggcca aatccgccgc cgaggtcgat 38340
ggccgcgggc tgggtgtgcg cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg 38400
gactcgatac gccgcctcat ccgctttttt gggggcgccc ggggaggcgg cggcgacggg 38460
gacggggacg acacgtcctc catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg 38520
ggggtggttt cgcgctgctc ctcttcccga ctggccattt ccttctccta taggcagaaa 38580
aagatcatgg agtcagtcga gaagaaggac agcctaaccg ccccctctga gttcgccacc 38640
accgcctcca ccgatgccgc caacgcgcct accaccttcc ccgtcgaggc acccccgctt 38700
gaggaggagg aagtgattat cgagcaggac ccaggttttg taagcgaaga cgacgaggac 38760
cgctcagtac caacagagga taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa 38820
caagtcgggc ggggggacga aaggcatggc gactacctag atgtgggaga cgacgtgctg 38880
ttgaagcatc tgcagcgcca gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat 38940
gtgcccctcg ccatagcgga tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc 39000
gtacccccca aacgccaaga aaacggcaca tgcgagccca acccgcgcct caacttctac 39060
cccgtatttg ccgtgccaga ggtgcttgcc acctatcaca tctttttcca aaactgcaag 39120
atacccctat cctgccgtgc caaccgcagc cgagcggaca agcagctggc cttgcggcag 39180
ggcgctgtca tacctgatat cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt 39240
ggacgcgacg agaagcgcgc ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt 39300
cactctggag tgttggtgga actcgagggt gacaacgcgc gcctagccgt actaaaacgc 39360
agcatcgagg tcacccactt tgcctacccg gcacttaacc taccccccaa ggtcatgagc 39420
acagtcatga gtgagctgat cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg 39480
caagaacaaa cagaggaggg cctacccgca gttggcgacg agcagctagc gcgctggctt 39540
caaacgcgcg agcctgccga cttggaggag cgacgcaaac taatgatggc cgcagtgctc 39600
gttaccgtgg agcttgagtg catgcagcgg ttctttgctg acccggagat gcagcgcaag 39660
ctagaggaaa cattgcacta cacctttcga cagggctacg tacgccaggc ctgcaagatc 39720
tccaacgtgg agctctgcaa cctggtctcc taccttggaa ttttgcacga aaaccgcctt 39780
gggcaaaacg tgcttcattc cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac 39840
tgcgtttact tatttctatg ctacacctgg cagacggcca tgggcgtttg gcagcagtgc 39900
ttggaggagt gcaacctcaa ggagctgcag aaactgctaa agcaaaactt gaaggaccta 39960
tggacggcct tcaacgagcg ctccgtggcc gcgcacctgg cggacatcat tttccccgaa 40020
cgcctgctta aaaccctgca acagggtctg ccagacttca ccagtcaaag catgttgcag 40080
aactttagga actttatcct agagcgctca ggaatcttgc ccgccacctg ctgtgcactt 40140
cctagcgact ttgtgcccat taagtaccgc gaatgccctc cgccgctttg gggccactgc 40200
taccttctgc agctagccaa ctaccttgcc taccactctg acataatgga agacgtgagc 40260
ggtgacggtc tactggagtg tcactgtcgc tgcaacctat gcaccccgca ccgctccctg 40320
gtttgcaatt cgcagctgct taacgaaagt caaattatcg gtacctttga gctgcagggt 40380
ccctcgcctg acgaaaagtc cgcggctccg gggttgaaac tcactccggg gctgtggacg 40440
tcggcttacc ttcgcaaatt tgtacctgag gactaccacg cccacgagat taggttctac 40500
gaagaccaat cccgcccgcc aaatgcggag cttaccgcct gcgtcattac ccagggccac 40560
attcttggcc aattgcaagc catcaacaaa gcccgccaag agtttctgct acgaaaggga 40620
cggggggttt acttggaccc ccagtccggc gaggagctca acccaatccc cccgccgccg 40680
cagccctatc agcagcagcc gcgggccctt gcttcccagg atggcaccca aaaagaagct 40740
gcagctgccg ccgccaccca cggacgagga ggaatactgg gacagtcagg cagaggaggt 40800
tttggacgag gaggaggagg acatgatgga agactgggag agcctagacg aggaagcttc 40860
cgaggtcgaa gaggtgtcag acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc 40920
gccccagaaa tcggcaaccg gttccagcat ggctacaacc tccgctcctc aggcgccgcc 40980
ggcactgccc gttcgccgac ccaaccgtag atgggacacc actggaacca gggccggtaa 41040
gtccaagcag ccgccgccgt tagcccaaga gcaacaacag cgccaaggct accgctcatg 41100
gcgcgggcac aagaacgcca tagttgcttg cttgcaagac tgtgggggca acatctcctt 41160
cgcccgccgc tttcttctct accatcacgg cgtggccttc ccccgtaaca tcctgcatta 41220
ctaccgtcat ctctacagcc catactgcac cggcggcagc ggcagcggca gcaacagcag 41280
cggccacaca gaagcaaagg cgaccggata gcaagactct gacaaagccc aagaaatcca 41340
cagcggcggc agcagcagga ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga 41400
cccgcgagct tagaaacagg atttttccca ctctgtatgc tatatttcaa cagagcaggg 41460
gccaagaaca agagctgaaa ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc 41520
tgtatcacaa aagcgaagat cagcttcggc gcacgctgga agacgcggag gctctcttca 41580
gtaaatactg cgcgctgact cttaaggact agtttcgcgc cctttctcaa atttaagcgc 41640
gaaaactacg tcatctccag cggccacacc cggcgccagc acctgtcgtc agcgccatta 41700
tgagcaagga aattcccacg ccctacatgt ggagttacca gccacaaatg ggacttgcgg 41760
ctggagctgc ccaagactac tcaacccgaa taaactacat gagcgcggga ccccacatga 41820
tatcccgggt caacggaatc cgcgcccacc gaaaccgaat tctcttggaa caggcggcta 41880
ttaccaccac acctcgtaat aaccttaatc cccgtagttg gcccgctgcc ctggtgtacc 41940
aggaaagtcc cgctcccacc actgtggtac ttcccagaga cgcccaggcc gaagttcaga 42000
tgactaactc aggggcgcag cttgcgggcg gctttcgtca cagggtgcgg tcgcccgggc 42060
agggtataac tcacctgaca atcagagggc gaggtattca gctcaacgac gagtcggtga 42120
gctcctcgct tggtctccgt ccggacggga catttcagat cggcggcgcc ggccgtcctt 42180
cattcacgcc tcgtcaggca atcctaactc tgcagacctc gtcctctgag ccgcgctctg 42240
gaggcattgg aactctgcaa tttattgagg agtttgtgcc atcggtctac tttaacccct 42300
tctcgggacc tcccggccac tatccggatc aatttattcc taactttgac gcggtaaagg 42360
actcggcgga cggctacgac tgaatgttaa gtggagaggc agagcaactg cgcctgaaac 42420
acctggtcca ctgtcgccgc cacaagtgct ttgcccgcga ctccggtgag ttttgctact 42480
ttgaattgcc cgaggatcat atcgagggcc cggcgcacgg cgtccggctt accgcccagg 42540
gagagcttgc ccgtagcctg attcgggagt ttacccagcg ccccctgcta gttgagcggg 42600
acaggggacc ctgtgttctc actgtgattt gcaactgtcc taaccttgga ttacatcaag 42660
atctttgttg ccatctctgt gctgagtata ataaatacag aaattaaaat atactggggc 42720
tcctatcgcc atcctgtaaa cgccaccgtc ttcacccgcc caagcaaacc aaggcgaacc 42780
ttacctggta cttttaacat ctctccctct gtgatttaca acagtttcaa cccagacgga 42840
gtgagtctac gagagaacct ctccgagctc agctactcca tcagaaaaaa caccaccctc 42900
cttacctgcc gggaacgtac gagtgcgtca ccggccgctg caccacacct accgcctgac 42960
cgtaaaccag actttttccg gacagacctc aataactctg tttaccagaa caggaggtga 43020
gcttagaaaa cccttagggt attaggccaa aggcgcagct actgtggggt ttatgaacaa 43080
ttcaagcaac tctacgggct attctaattc aggtttctct agaaatggac ggaattatta 43140
cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 43200
agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 43260
aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 43320
ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 43380
cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 43440
ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 43500
taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 43560
tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 43620
aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 43680
ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 43740
gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 43800
gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 43860
tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 43920
cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 43980
aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 44040
gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 44100
cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 44160
gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 44220
tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 44280
acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 44340
aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 44400
aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 44460
ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 44520
gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 44580
aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 44640
aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 44700
attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 44760
aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 44820
ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 44880
aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa tgcagagaaa 44940
gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc tacagtttca 45000
gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag tgctcatctt 45060
attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga cccagaatat 45120
tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc tgttggattt 45180
atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag taacattgtc 45240
agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat tacactaaac 45300
ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt ttcatgggac 45360
tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac tttttcatac 45420
attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 45480
gaaaatttcg aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag 45540
atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac ctccctccca 45600
acacacagag tacacagtcc tttctccccg gctggcctta aaaagcatca tatcatgggt 45660
aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca aacgctcatc 45720
agtgatatta ataaactccc cgggcagctc acttaagttc atgtcgctgt ccagctgctg 45780
agccacaggc tgctgtccaa cttgcggttg cttaacgggc ggcgaaggag aagtccacgc 45840
ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc 45900
gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc 45960
ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg 46020
caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa 46080
aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg 46140
gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat 46200
aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg 46260
attaaacatg gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc 46320
tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc 46380
atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca 46440
cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc 46500
ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat 46560
tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc 46620
tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg 46680
tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa 46740
accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg 46800
tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt 46860
ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca 46920
cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg 46980
gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct 47040
attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata 47100
atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag 47160
tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca 47220
accatgccca aataattctc atctcgccac cttctcaata tatctctaag caaatcccga 47280
atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag 47340
cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg 47400
gaacattaac aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat 47460
cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccttg acaaaagaac 47520
ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag 47580
ctttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc 47640
tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca ggtaagctcc 47700
ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg tttctgcata 47760
aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt acaacaggaa 47820
aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg taaaaaaact 47880
ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga gtcataatgt 47940
aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag cgaccgaaat 48000
agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc ataggaggta 48060
taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc tgcctaggca 48120
aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca gccataacag 48180
tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca cggcacataa 48240
cttcgtatag catacattat acgaagttat cagctcaatc agtcacagtg taaaaaaggg 48300
ccaagtgcag agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa 48360
aaacacccag aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa 48420
cttcctcaaa tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact 48480
acaattccca acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc 48540
acgccccgcg ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa 48600
taaggtatat tattgatgat gcctccgggg tccactgcaa ttaataactt cgtatagcat 48660
acattatacg aagttattta attaagggcg gccgcacggg ccatcgatgg ggatcctaac 48720
tttaaataat gccaattatt taaagttacc aactattttg tccgcccaca ggtaccctgt 48780
gaatgcgcaa accaaccctt ggcagaacat atccatcgcg tccgccatct ccagcagccg 48840
cacgcggcgc atctcgggca gcgttgggtc ctggccacgg gtgcgcatga tcgtgctcct 48900
gtcgttgagg acccggctag gctggcgggg ttgccttact ggttagcaga atgaatcacc 48960
gatacgcgag cgaacgtgaa gcgactgctg ctgcaaaacg tctgcgacct gagcaacaac 49020
atgaatggtc ttcggtttcc gtgtttcgta aagtctggaa acgcggaagt cagcgccctg 49080
caccattatg ttccggaacg tacgaagcat gctaattttg tgttactcat gca 49133
<210> 54
<211> 6699
<212> DNA
<213> 人工序列
<220>
<223> pAR-Int4-Cas9-Amp
<400> 54
ttatcgtttc agacccacct cccaaccccg aggggaccca gagagggcct atttcccatg 60
attccttcat atttgcatat acgatacaag gctgttagag agataattag aattaatttg 120
actgtaaaca caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg 180
tagtttgcag ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga 240
aagtatttcg atttcttggc tttatatatc ttgtggaaag gacgaaacac ctatattata 300
tagatagcct cgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa 360
cttgaaaaag tggcaccgag tcggtgcttt tttaagcttg aattcgctag ctaggtcttg 420
aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc 480
cccgagaagt tggggggagg ggtcggcaat tgatccggtg cctagagaag gtggcgcggg 540
gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa 600
ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga 660
acacaggacc ggttctagag ccaccatgga caagaagtac agcatcggcc tggacatcgg 720
caccaactct gtgggctggg ccgtgatcac cgacgagtac aaggtgccca gcaagaaatt 780
caaggtgctg ggcaacaccg accggcacag catcaagaag aacctgatcg gagccctgct 840
gttcgacagc ggcgaaacag ccgaggccac ccggctgaag agaaccgcca gaagaagata 900
caccagacgg aagaaccgga tctgctatct gcaagagatc ttcagcaacg agatggccaa 960
ggtggacgac agcttcttcc acagactgga agagtccttc ctggtggaag aggataagaa 1020
gcacgagcgg caccccatct tcggcaacat cgtggacgag gtggcctacc acgagaagta 1080
ccccaccatc taccacctga gaaagaaact ggtggacagc accgacaagg ccgacctgcg 1140
gctgatctat ctggccctgg cccacatgat caagttccgg ggccacttcc tgatcgaggg 1200
cgacctgaac cccgacaaca gcgacgtgga caagctgttc atccagctgg tgcagaccta 1260
caaccagctg ttcgaggaaa accccatcaa cgccagcggc gtggacgcca aggccatcct 1320
gtctgccaga ctgagcaaga gcagacggct ggaaaatctg atcgcccagc tgcccggcga 1380
gaagaagaat ggcctgttcg gaaacctgat tgccctgagc ctgggcctga cccccaactt 1440
caagagcaac ttcgacctgg ccgaggatgc caaactgcag ctgagcaagg acacctacga 1500
cgacgacctg gacaacctgc tggcccagat cggcgaccag tacgccgacc tgtttctggc 1560
cgccaagaac ctgtccgacg ccatcctgct gagcgacatc ctgagagtga acaccgagat 1620
caccaaggcc cccctgagcg cctctatgat caagagatac gacgagcacc accaggacct 1680
gaccctgctg aaagctctcg tgcggcagca gctgcctgag aagtacaaag agattttctt 1740
cgaccagagc aagaacggct acgccggcta cattgacggc ggagccagcc aggaagagtt 1800
ctacaagttc atcaagccca tcctggaaaa gatggacggc accgaggaac tgctcgtgaa 1860
gctgaacaga gaggacctgc tgcggaagca gcggaccttc gacaacggca gcatccccca 1920
ccagatccac ctgggagagc tgcacgccat tctgcggcgg caggaagatt tttacccatt 1980
cctgaaggac aaccgggaaa agatcgagaa gatcctgacc ttccgcatcc cctactacgt 2040
gggccctctg gccaggggaa acagcagatt cgcctggatg accagaaaga gcgaggaaac 2100
catcaccccc tggaacttcg aggaagtggt ggacaagggc gcttccgccc agagcttcat 2160
cgagcggatg accaacttcg ataagaacct gcccaacgag aaggtgctgc ccaagcacag 2220
cctgctgtac gagtacttca ccgtgtataa cgagctgacc aaagtgaaat acgtgaccga 2280
gggaatgaga aagcccgcct tcctgagcgg cgagcagaaa aaggccatcg tggacctgct 2340
gttcaagacc aaccggaaag tgaccgtgaa gcagctgaaa gaggactact tcaagaaaat 2400
cgagtgcttc gactccgtgg aaatctccgg cgtggaagat cggttcaacg cctccctggg 2460
cacataccac gatctgctga aaattatcaa ggacaaggac ttcctggaca atgaggaaaa 2520
cgaggacatt ctggaagata tcgtgctgac cctgacactg tttgaggaca gagagatgat 2580
cgaggaacgg ctgaaaacct atgcccacct gttcgacgac aaagtgatga agcagctgaa 2640
gcggcggaga tacaccggct ggggcaggct gagccggaag ctgatcaacg gcatccggga 2700
caagcagtcc ggcaagacaa tcctggattt cctgaagtcc gacggcttcg ccaacagaaa 2760
cttcatgcag ctgatccacg acgacagcct gacctttaaa gaggacatcc agaaagccca 2820
ggtgtccggc cagggcgata gcctgcacga gcacattgcc aatctggccg gcagccccgc 2880
cattaagaag ggcatcctgc agacagtgaa ggtggtggac gagctcgtga aagtgatggg 2940
ccggcacaag cccgagaaca tcgtgatcga aatggccaga gagaaccaga ccacccagaa 3000
gggacagaag aacagccgcg agagaatgaa gcggatcgaa gagggcatca aagagctggg 3060
cagccagatc ctgaaagaac accccgtgga aaacacccag ctgcagaacg agaagctgta 3120
cctgtactac ctgcagaatg ggcgggatat gtacgtggac caggaactgg acatcaaccg 3180
gctgtccgac tacgatgtgg accatatcgt gcctcagagc tttctgaagg acgactccat 3240
cgacaacaag gtgctgacca gaagcgacaa gaaccggggc aagagcgaca acgtgccctc 3300
cgaagaggtc gtgaagaaga tgaagaacta ctggcggcag ctgctgaacg ccaagctgat 3360
tacccagaga aagttcgaca atctgaccaa ggccgagaga ggcggcctga gcgaactgga 3420
taaggccggc ttcatcaaga gacagctggt ggaaacccgg cagatcacaa agcacgtggc 3480
acagatcctg gactcccgga tgaacactaa gtacgacgag aatgacaagc tgatccggga 3540
agtgaaagtg atcaccctga agtccaagct ggtgtccgat ttccggaagg atttccagtt 3600
ttacaaagtg cgcgagatca acaactacca ccacgcccac gacgcctacc tgaacgccgt 3660
cgtgggaacc gccctgatca aaaagtaccc taagctggaa agcgagttcg tgtacggcga 3720
ctacaaggtg tacgacgtgc ggaagatgat cgccaagagc gagcaggaaa tcggcaaggc 3780
taccgccaag tacttcttct acagcaacat catgaacttt ttcaagaccg agattaccct 3840
ggccaacggc gagatccgga agcggcctct gatcgagaca aacggcgaaa ccggggagat 3900
cgtgtgggat aagggccggg attttgccac cgtgcggaaa gtgctgagca tgccccaagt 3960
gaatatcgtg aaaaagaccg aggtgcagac aggcggcttc agcaaagagt ctatcctgcc 4020
caagaggaac agcgataagc tgatcgccag aaagaaggac tgggacccta agaagtacgg 4080
cggcttcgac agccccaccg tggcctattc tgtgctggtg gtggccaaag tggaaaaggg 4140
caagtccaag aaactgaaga gtgtgaaaga gctgctgggg atcaccatca tggaaagaag 4200
cagcttcgag aagaatccca tcgactttct ggaagccaag ggctacaaag aagtgaaaaa 4260
ggacctgatc atcaagctgc ctaagtactc cctgttcgag ctggaaaacg gccggaagag 4320
aatgctggcc tctgccggcg aactgcagaa gggaaacgaa ctggccctgc cctccaaata 4380
tgtgaacttc ctgtacctgg ccagccacta tgagaagctg aagggctccc ccgaggataa 4440
tgagcagaaa cagctgtttg tggaacagca caagcactac ctggacgaga tcatcgagca 4500
gatcagcgag ttctccaaga gagtgatcct ggccgacgct aatctggaca aagtgctgtc 4560
cgcctacaac aagcaccggg ataagcccat cagagagcag gccgagaata tcatccacct 4620
gtttaccctg accaatctgg gagcccctgc cgccttcaag tactttgaca ccaccatcga 4680
ccggaagagg tacaccagca ccaaagaggt gctggacgcc accctgatcc accagagcat 4740
caccggcctg tacgagacac ggatcgacct gtctcagctg ggaggcgaca agcgacctgc 4800
cgccacaaag aaggctggac aggctaagaa gaagaaagat tacaaagacg atgacgataa 4860
gtgactcgag tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt 4920
tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca 4980
ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt 5040
ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga 5100
tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa 5160
gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct 5220
gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat 5280
acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga 5340
tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc 5400
caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat 5460
gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa 5520
cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac 5580
tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa 5640
agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc 5700
tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc 5760
ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag 5820
acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta 5880
ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa 5940
gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc 6000
gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat 6060
ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga 6120
gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt 6180
ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata 6240
cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac 6300
cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg 6360
ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg 6420
tgagcattga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag 6480
cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct 6540
ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc 6600
aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt 6660
ttgctggcct tttgctcaca tgttctttcc tgcgatgca 6699
<210> 55
<211> 3500
<212> DNA
<213> 人工序列
<220>
<223> pO6-A5-WH18/19-mChe
<400> 55
gaagttccta ttctctagaa agtataggaa cttcaattcc catgtcagcc gttaagtgtt 60
cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 120
ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 180
ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 240
gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 300
ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 360
gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 420
atcttcagat cctctacgcc ggacgcatcg tggccttaat taacatatgg atttattcaa 480
caaagccacg ttgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca 540
tcatgaacaa taaaactgtc tgcttacata aacagtaata caaggggtgt tatgagccat 600
attcaacggg aaacgtcttg ctcgaggccg cgattaaatt ccaacatgga tgctgattta 660
tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgattg 720
tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat 780
gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc 840
atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccggg 900
aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg 960
ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc 1020
gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg 1080
agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat 1140
aagcttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac 1200
cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca 1260
gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta 1320
cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt 1380
catttgatgc tcgatgagtt tttctaatca gaattggtta attggttgta acactgggca 1440
tgctaattgc agtggacccc ggcaaattcc ttggcatcat caataatata ccttattttg 1500
gattgaagcc aatatgataa tgagggggtg gagtttgtga cgtggcgcgg ggcgtgggaa 1560
cggggcgggt gacgtagtag tgtggcggaa gtgtgatgtt gcaagtgtgg cggaacacat 1620
gtaagcgacg gatgtggcaa aagtgacgtt tttggtgtgc gccggtgtac acaggaagtg 1680
acaattttcg cgcggtttta ggcggatgtt gtagtaaatt tgggcgtaac cgagtaagat 1740
ttggccattt tcgcgggaaa actgaataag aggaagtgaa atctgaataa ttttgtgtta 1800
ctcatagcgc gtaataatag taatcaatta cggggtcatt agttcatagc ccatatatgg 1860
agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc 1920
gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt 1980
gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc 2040
atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg 2100
cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg 2160
ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact 2220
cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa 2280
atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta 2340
ggcgtgtacg gtgggaggtc tatataagca gagctggttt agtgaaccgt cagatccgct 2400
agcgctaccg gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgag 2460
ctcggatccc gccaccatgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga 2520
gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga 2580
gggcgagggc gagggccgcc cctacgaggg cacccagacc gccaagctga aggtgaccaa 2640
gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa 2700
ggcctacgtg aagcaccccg ccgacatccc cgactacttg aagctgtcct tccccgaggg 2760
cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg tgacccagga 2820
ctcctccctg caggacggcg agttcatcta caaggtgaag ctgcgcggca ccaacttccc 2880
ctccgacggc cccgtaatgc agaagaagac catgggctgg gaggcctcct ccgagcggat 2940
gtaccccgag gacggcgccc tgaagggcga gatcaagcag aggctgaagc tgaaggacgg 3000
cggccactac gacgctgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc 3060
cggcgcctac aacgtcaaca tcaagttgga catcacctcc cacaacgagg actacaccat 3120
cgtggaacag tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta 3180
caagtaagaa ttctgcagat atccagcaca gtggcggccg cgactctaga tcataatcag 3240
ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 3300
cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 3360
ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 3420
tagttgtggt ttgtccaaac tcatcaatgt atcttaaatc gaattcaagc ttgtcgactc 3480
gaagatctga gctcacgcgt 3500
<210> 56
<211> 40951
<212> DNA
<213> 人工序列
<220>
<223> pBWH18/19-C5-mChe
<400> 56
gtagtgatct tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc 60
attttcgcca aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt 120
attctgcgaa gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt 180
aaccgtcgca caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc 240
aggacctgga ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt 300
ccggtcacac cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata 360
ccgctgaaag ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac 420
acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag 480
tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat 540
ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt 600
atccactgag aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat 660
tattaatctc aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc 720
aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg 780
ttacgttgaa gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa 840
ccatgatgtg gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag 900
ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat 960
gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt tataattatt 1020
ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg 1080
ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac 1140
agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt 1200
tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa 1260
cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac 1320
gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct 1380
cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca 1440
ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg 1500
gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga 1560
aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt 1620
ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca 1680
acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta 1740
gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt 1800
atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt 1860
accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct 1920
gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag 1980
gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat 2040
agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact 2100
gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt 2160
ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt 2220
ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt 2280
tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt 2340
tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc 2400
ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta 2460
gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat 2520
tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat 2580
tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat 2640
ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc 2700
acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga 2760
agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg 2820
actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat 2880
tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt 2940
atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc 3000
tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa 3060
cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc 3120
agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa 3180
gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga 3240
aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct 3300
ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc 3360
taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac 3420
gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct 3480
gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata 3540
cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg 3600
aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg 3660
gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa 3720
tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg 3780
ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa 3840
ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg 3900
cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg 3960
aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca 4020
ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct 4080
tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa 4140
attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt 4200
ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg taacgattat 4260
cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt 4320
gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc 4380
tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa 4440
ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt 4500
aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa 4560
gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta 4620
agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg 4680
cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt 4740
aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct 4800
ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg 4860
cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt 4920
atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 4980
tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt 5040
cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg 5100
tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 5160
aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 5220
tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta 5280
tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga 5340
ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt 5400
aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa 5460
cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta 5520
accgggctgc atccgatgca agtgtgtcgc tgtcgagttt tcgggggagt ccagggtttt 5580
cccagtcacg acgttgtaaa acgacggcca gtgaattcga gctcggtacc cggggatctt 5640
gaagttccta ttctctagaa agtataggaa cttcaattcc catgtcagcc gttaagtgtt 5700
cctgtgtcac tcaaaattgc tttgagaggc tctaagggct tctcagtgcg ttacatccct 5760
ggcttgttgt ccacaaccgt taaaccttaa aagctttaaa agccttatat attctttttt 5820
ttcttataaa acttaaaacc ttagaggcta tttaagttgc tgatttatat taattttatt 5880
gttcaaacat gagagcttag tacgtgaaac atgagagctt agtacgttag ccatgagagc 5940
ttagtacgtt agccatgagg gtttagttcg ttaaacatga gagcttagta cgttaaacat 6000
gagagcttag tacgtgaaac atgagagctt agtacgtact atcaacaggt tgaactgctg 6060
atcttcagat cctctacgcc ggacgcatcg tggccttaat taacatatgg atttattcaa 6120
caaagccacg ttgtgtctca aaatctctga tgttacattg cacaagataa aaatatatca 6180
tcatgaacaa taaaactgtc tgcttacata aacagtaata caaggggtgt tatgagccat 6240
attcaacggg aaacgtcttg ctcgaggccg cgattaaatt ccaacatgga tgctgattta 6300
tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgattg 6360
tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat 6420
gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc 6480
atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccggg 6540
aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg 6600
ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc 6660
gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg 6720
agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat 6780
aagcttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac 6840
cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca 6900
gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta 6960
cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt 7020
catttgatgc tcgatgagtt tttctaatca gaattggtta attggttgta acactgggca 7080
tgctaattgc agtggacccc ggcaaattcc ttggcatcat caataatata ccttattttg 7140
gattgaagcc aatatgataa tgagggggtg gagtttgtga cgtggcgcgg ggcgtgggaa 7200
cggggcgggt gacgtagtag tgtggcggaa gtgtgatgtt gcaagtgtgg cggaacacat 7260
gtaagcgacg gatgtggcaa aagtgacgtt tttggtgtgc gccggtgtac acaggaagtg 7320
acaattttcg cgcggtttta ggcggatgtt gtagtaaatt tgggcgtaac cgagtaagat 7380
ttggccattt tcgcgggaaa actgaataag aggaagtgaa atctgaataa ttttgtgtta 7440
ctcatagcgc gtaataatag taatcaatta cggggtcatt agttcatagc ccatatatgg 7500
agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc 7560
gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt 7620
gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc 7680
atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg 7740
cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg 7800
ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact 7860
cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa 7920
atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta 7980
ggcgtgtacg gtgggaggtc tatataagca gagctggttt agtgaaccgt cagatccgct 8040
agcgctaccg gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgag 8100
ctcggatccc gccaccatgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga 8160
gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga 8220
gggcgagggc gagggccgcc cctacgaggg cacccagacc gccaagctga aggtgaccaa 8280
gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa 8340
ggcctacgtg aagcaccccg ccgacatccc cgactacttg aagctgtcct tccccgaggg 8400
cttcaagtgg gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg tgacccagga 8460
ctcctccctg caggacggcg agttcatcta caaggtgaag ctgcgcggca ccaacttccc 8520
ctccgacggc cccgtaatgc agaagaagac catgggctgg gaggcctcct ccgagcggat 8580
gtaccccgag gacggcgccc tgaagggcga gatcaagcag aggctgaagc tgaaggacgg 8640
cggccactac gacgctgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc 8700
cggcgcctac aacgtcaaca tcaagttgga catcacctcc cacaacgagg actacaccat 8760
cgtggaacag tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta 8820
caagtaagaa ttctgcagat atccagcaca gtggcggccg cgactctaga tcataatcag 8880
ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 8940
cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 9000
ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 9060
tagttgtggt ttgtccaaac tcatcaatgt atcttaaatc gaattcaagc ttgtcgactc 9120
gaagatctga gctcacgcgt gaagttccta ttccgaagtt cctattctct agaaagtata 9180
ggaacttcag agcgcttttg aagctggggt gggcgaagaa ctccagcatg agatccccag 9240
agcgcttttg aagctgcgtt taaacgcgat atcccgggag ctcccgatat cgcgtttaaa 9300
cgcagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca 9360
attccacaca acatacgagc cggaagactg aaatgtgtgg gcgtggctta agggtgggaa 9420
agaatatata aggtgggggt cttatgtagt tttgtatctg ttttgcagca gccgccgccg 9480
ccatgagcac caactcgttt gatggaagca ttgtgagctc atatttgaca acgcgcatgc 9540
ccccatgggc cggggtgcgt cagaatgtga tgggctccag cattgatggt cgccccgtcc 9600
tgcccgcaaa ctctactacc ttgacctacg agaccgtgtc tggaacgccg ttggagactg 9660
cagcctccgc cgccgcttca gccgctgcag ccaccgcccg cgggattgtg actgactttg 9720
ctttcctgag cccgcttgca agcagtgcag cttcccgttc atccgcccgc gatgacaagt 9780
tgacggctct tttggcacaa ttggattctt tgacccggga acttaatgtc gtttctcagc 9840
agctgttgga tctgcgccag caggtttctg ccctgaaggc ttcctcccct cccaatgcgg 9900
tttaaaacat aaataaaaaa ccagactctg tttggatttg gatcaagcaa gtgtcttgct 9960
gtctttattt aggggttttg cgcgcgcggt aggcccggga ccagcggtct cggtcgttga 10020
gggtcctgtg tattttttcc aggacgtggt aaaggtgact ctggatgttc agatacatgg 10080
gcataagccc gtctctgggg tggaggtagc accactgcag agcttcatgc tgcggggtgg 10140
tgttgtagat gatccagtcg tagcaggagc gctgggcgtg gtgcctaaaa atgtctttca 10200
gtagcaagct gattgccagg ggcaggccct tggtgtaagt gtttacaaag cggttaagct 10260
gggatgggtg catacgtggg gatatgagat gcatcttgga ctgtattttt aggttggcta 10320
tgttcccagc catatccctc cggggattca tgttgtgcag aaccaccagc acagtgtatc 10380
cggtgcactt gggaaatttg tcatgtagct tagaaggaaa tgcgtggaag aacttggaga 10440
cgcccttgtg acctccaaga ttttccatgc attcgtccat aatgatggca atgggcccac 10500
gggcggcggc ctgggcgaag atatttctgg gatcactaac gtcatagttg tgttccagga 10560
tgagatcgtc ataggccatt tttacaaagc gcgggcggag ggtgccagac tgcggtataa 10620
tggttccatc cggcccaggg gcgtagttac cctcacagat ttgcatttcc cacgctttga 10680
gttcagatgg ggggatcatg tctacctgcg gggcgatgaa gaaaacggtt tccggggtag 10740
gggagatcag ctgggaagaa agcaggttcc tgagcagctg cgacttaccg cagccggtgg 10800
gcccgtaaat cacacctatt accgggtgca actggtagtt aagagagctg cagctgccgt 10860
catccctgag caggggggcc acttcgttaa gcatgtccct gactcgcatg ttttccctga 10920
ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt 10980
ttttcaacgg tttgagaccg tccgccgtag gcatgctttt gagcgtttga ccaagcagtt 11040
ccaggcggtc ccacagctcg gtcacctgct ctacggcatc tcgatccagc atatctcctc 11100
gtttcgcggg ttggggcggc tttcgctgta cggcagtagt cggtgctcgt ccagacgggc 11160
cagggtcatg tctttccacg ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa 11220
ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg aggctggtcc tgctggtgct 11280
gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag catttgacca tggtgtcata 11340
gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg cccttggagg aggcgccgca 11400
cgaggggcag tgcagacttt tgagggcgta gagcttgggc gcgagaaata ccgattccgg 11460
ggagtaggca tccgcgccgc aggccccgca gacggtctcg cattccacga gccaggtgag 11520
ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc tttttgatgc gtttcttacc 11580
tctggtttcc atgagccggt gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta 11640
tacagacttg agaggcctgt cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc 11700
ggaccactct gagacaaagg ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg 11760
gtagcggtcg ttgtccacta gggggtccac tcgctccagg gtgtgaagac acatgtcgcc 11820
ctcttcggca tcaaggaagg tgattggttt gtaggtgtag gccacgtgac cgggtgttcc 11880
tgaagggggg ctataaaagg gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct 11940
gtctgcgagg gccagctgtt ggggtgagta ctccctctga aaagcgggca tgacttctgc 12000
gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc ccgcggtgat 12060
gcctttgagg gtggccgcat ccatctggtc agaaaagaca atctttttgt tgtcaagctt 12120
ggtggcaaac gacccgtaga gggcgttgga cagcaacttg gcgatggagc gcagggtttg 12180
gtttttgtcg cgatcggcgc gctccttggc cgcgatgttt agctgcacgt attcgcgcgc 12240
aacgcaccgc cattcgggaa agacggtggt gcgctcgtcg ggcaccaggt gcacgcgcca 12300
accgcggttg tgcagggtga caaggtcaac gctggtggct acctctccgc gtaggcgctc 12360
gttggtccag cagaggcggc cgcccttgcg cgagcagaat ggcggtaggg ggtctagctg 12420
cgtctcgtcc ggggggtctg cgtccacggt aaagaccccg ggcagcaggc gcgcgtcgaa 12480
gtagtctatc ttgcatcctt gcaagtctag cgcctgctgc catgcgcggg cggcaagcgc 12540
gcgctcgtat gggttgagtg ggggacccca tggcatgggg tgggtgagcg cggaggcgta 12600
catgccgcaa atgtcgtaaa cgtagagggg ctctctgagt attccaagat atgtagggta 12660
gcatcttcca ccgcggatgc tggcgcgcac gtaatcgtat agttcgtgcg agggagcgag 12720
gaggtcggga ccgaggttgc tacgggcggg ctgctctgct cggaagacta tctgcctgaa 12780
gatggcatgt gagttggatg atatggttgg acgctggaag acgttgaagc tggcgtctgt 12840
gagacctacc gcgtcacgca cgaaggaggc gtaggagtcg cgcagcttgt tgaccagctc 12900
ggcggtgacc tgcacgtcta gggcgcagta gtccagggtt tccttgatga tgtcatactt 12960
atcctgtccc ttttttttcc acagctcgcg gttgaggaca aactcttcgc ggtctttcca 13020
gtactcttgg atcggaaacc cgtcggcctc cgaacggtaa gagcctagca tgtagaactg 13080
gttgacggcc tggtaggcgc agcatccctt ttctacgggt agcgcgtatg cctgcgcggc 13140
cttccggagc gaggtgtggg tgagcgcaaa ggtgtccctg accatgactt tgaggtactg 13200
gtatttgaag tcagtgtcgt cgcatccgcc ctgctcccag agcaaaaagt ccgtgcgctt 13260
tttggaacgc ggatttggca gggcgaaggt gacatcgttg aagagtatct ttcccgcgcg 13320
aggcataaag ttgcgtgtga tgcggaaggg tcccggcacc tcggaacggt tgttaattac 13380
ctgggcggcg agcacgatct cgtcaaagcc gttgatgttg tggcccacaa tgtaaagttc 13440
caagaagcgc gggatgccct tgatggaagg caatttttta agttcctcgt aggtgagctc 13500
ttcaggggag ctgagcccgt gctctgaaag ggcccagtct gcaagatgag ggttggaagc 13560
gacgaatgag ctccacaggt cacgggccat tagcatttgc aggtggtcgc gaaaggtcct 13620
aaactggcga cctatggcca ttttttctgg ggtgatgcag tagaaggtaa gcgggtcttg 13680
ttcccagcgg tcccatccaa ggttcgcggc taggtctcgc gcggcagtca ctagaggctc 13740
atctccgccg aacttcatga ccagcatgaa gggcacgagc tgcttcccaa aggcccccat 13800
ccaagtatag gtctctacat cgtaggtgac aaagagacgc tcggtgcgag gatgcgagcc 13860
gatcgggaag aactggatct cccgccacca attggaggag tggctattga tgtggtgaaa 13920
gtagaagtcc ctgcgacggg ccgaacactc gtgctggctt ttgtaaaaac gtgcgcagta 13980
ctggcagcgg tgcacgggct gtacatcctg cacgaggttg acctgacgac cgcgcacaag 14040
gaagcagagt gggaatttga gcccctcgcc tggcgggttt ggctggtggt cttctacttc 14100
ggctgcttgt ccttgaccgt ctggctgctc gaggggagtt acggtggatc ggaccaccac 14160
gccgcgcgag cccaaagtcc agatgtccgc gcgcggcggt cggagcttga tgacaacatc 14220
gcgcagatgg gagctgtcca tggtctggag ctcccgcggc gtcaggtcag gcgggagctc 14280
ctgcaggttt acctcgcata gacgggtcag ggcgcgggct agatccaggt gatacctaat 14340
ttccaggggc tggttggtgg cggcgtcgat ggcttgcaag aggccgcatc cccgcggcgc 14400
gactacggta ccgcgcggcg ggcggtgggc cgcgggggtg tccttggatg atgcatctaa 14460
aagcggtgac gcgggcgagc ccccggaggt agggggggct ccggacccgc cgggagaggg 14520
ggcaggggca cgtcggcgcc gcgcgcgggc aggagctggt gctgcgcgcg taggttgctg 14580
gcgaacgcga cgacgcggcg gttgatctcc tgaatctggc gcctctgcgt gaagacgacg 14640
ggcccggtga gcttgagcct gaaagagagt tcgacagaat caatttcggt gtcgttgacg 14700
gcggcctggc gcaaaatctc ctgcacgtct cctgagttgt cttgataggc gatctcggcc 14760
atgaactgct cgatctcttc ctcctggaga tctccgcgtc cggctcgctc cacggtggcg 14820
gcgaggtcgt tggaaatgcg ggccatgagc tgcgagaagg cgttgaggcc tccctcgttc 14880
cagacgcggc tgtagaccac gcccccttcg gcatcgcggg cgcgcatgac cacctgcgcg 14940
agattgagct ccacgtgccg ggcgaagacg gcgtagtttc gcaggcgctg aaagaggtag 15000
ttgagggtgg tggcggtgtg ttctgccacg aagaagtaca taacccagcg tcgcaacgtg 15060
gattcgttga tatcccccaa ggcctcaagg cgctccatgg cctcgtagaa gtccacggcg 15120
aagttgaaaa actgggagtt gcgcgccgac acggttaact cctcctccag aagacggatg 15180
agctcggcga cagtgtcgcg cacctcgcgc tcaaaggcta caggggcctc ttcttcttct 15240
tcaatctcct cttccataag ggcctcccct tcttcttctt ctggcggcgg tgggggaggg 15300
gggacacggc ggcgacgacg gcgcaccggg aggcggtcga caaagcgctc gatcatctcc 15360
ccgcggcgac ggcgcatggt ctcggtgacg gcgcggccgt tctcgcgggg gcgcagttgg 15420
aagacgccgc ccgtcatgtc ccggttatgg gttggcgggg ggctgccatg cggcagggat 15480
acggcgctaa cgatgcatct caacaattgt tgtgtaggta ctccgccgcc gagggacctg 15540
agcgagtccg catcgaccgg atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag 15600
tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc ggcggtcggg gttgtttctg 15660
gcggaggtgc tgctgatgat gtaattaaag taggcggtct tgagacggcg gatggtcgac 15720
agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag 15780
gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc 15840
acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg 15900
gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc 15960
ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc 16020
gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg 16080
gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc 16140
tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc 16200
accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt 16260
agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg 16320
tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg 16380
cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc 16440
aggcgcgcgc aatcgttgac gctctagacc gtgcaaaagg agagcctgta agcgggcact 16500
cttccgtggt ctggtggata aattcgcaag ggtatcatgg cggacgaccg gggttcgagc 16560
cccgtatccg gccgtccgcc gtgatccatg cggttaccgc ccgcgtgtcg aacccaggtg 16620
tgcgacgtca gacaacgggg gagtgctcct tttggcttcc ttccaggcgc ggcggctgct 16680
gcgctagctt ttttggccac tggccgcgcg cagcgtaagc ggttaggctg gaaagcgaaa 16740
gcattaagtg gctcgctccc tgtagccgga gggttatttt ccaagggttg agtcgcggga 16800
cccccggttc gagtctcgga ccggccggac tgcggcgaac gggggtttgc ctccccgtca 16860
tgcaagaccc cgcttgcaaa ttcctccgga aacagggacg agcccctttt ttgcttttcc 16920
cagatgcatc cggtgctgcg gcagatgcgc ccccctcctc agcagcggca agagcaagag 16980
cagcggcaga catgcagggc accctcccct cctcctaccg cgtcaggagg ggcgacatcc 17040
gcggttgacg cggcagcaga tggtgattac gaacccccgc ggcgccgggc ccggcactac 17100
ctggacttgg aggagggcga gggcctggcg cggctaggag cgccctctcc tgagcggtac 17160
ccaagggtgc agctgaagcg tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt 17220
cgcgaccgcg agggagagga gcccgaggag atgcgggatc gaaagttcca cgcagggcgc 17280
gagctgcggc atggcctgaa tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac 17340
gcgcgaaccg ggattagtcc cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca 17400
tacgagcaga cggtgaacca ggagattaac tttcaaaaaa gctttaacaa ccacgtgcgt 17460
acgcttgtgg cgcgcgagga ggtggctata ggactgatgc atctgtggga ctttgtaagc 17520
gcgctggagc aaaacccaaa tagcaagccg ctcatggcgc agctgttcct tatagtgcag 17580
cacagcaggg acaacgaggc attcagggat gcgctgctaa acatagtaga gcccgagggc 17640
cgctggctgc tcgatttgat aaacatcctg cagagcatag tggtgcagga gcgcagcttg 17700
agcctggctg acaaggtggc cgccatcaac tattccatgc ttagcctggg caagttttac 17760
gcccgcaaga tataccatac cccttacgtt cccatagaca aggaggtaaa gatcgagggg 17820
ttctacatgc gcatggcgct gaaggtgctt accttgagcg acgacctggg cgtttatcgc 17880
aacgagcgca tccacaaggc cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag 17940
ctgatgcaca gcctgcaaag ggccctggct ggcacgggca gcggcgatag agaggccgag 18000
tcctactttg acgcgggcgc tgacctgcgc tgggccccaa gccgacgcgc cctggaggca 18060
gctggggccg gacctgggct ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg 18120
gaggaatatg acgaggacga tgagtacgag ccagaggacg gcgagtacta agcggtgatg 18180
tttctgatca gatgatgcaa gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc 18240
agccgtccgg ccttaactcc acggacgact ggcgccaggt catggaccgc atcatgtcgc 18300
tgactgcgcg caatcctgac gcgttccggc agcagccgca ggccaaccgg ctctccgcaa 18360
ttctggaagc ggtggtcccg gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg 18420
taaacgcgct ggccgaaaac agggccatcc ggcccgacga ggccggcctg gtctacgacg 18480
cgctgcttca gcgcgtggct cgttacaaca gcggcaacgt gcagaccaac ctggaccggc 18540
tggtggggga tgtgcgcgag gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc 18600
tgggctccat ggttgcacta aacgccttcc tgagtacaca gcccgccaac gtgccgcggg 18660
gacaggagga ctacaccaac tttgtgagcg cactgcggct aatggtgact gagacaccgc 18720
aaagtgaggt gtaccagtct gggccagact attttttcca gaccagtaga caaggcctgc 18780
agaccgtaaa cctgagccag gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc 18840
ccacaggcga ccgcgcgacc gtgtctagct tgctgacgcc caactcgcgc ctgttgctgc 18900
tgctaatagc gcccttcacg gacagtggca gcgtgtcccg ggacacatac ctaggtcact 18960
tgctgacact gtaccgcgag gccataggtc aggcgcatgt ggacgagcat actttccagg 19020
agattacaag tgtcagccgc gcgctggggc aggaggacac gggcagcctg gaggcaaccc 19080
taaactacct gctgaccaac cggcggcaga agatcccctc gttgcacagt ttaaacagcg 19140
aggaggagcg cattttgcgc tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg 19200
gggtaacgcc cagcgtggcg ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg 19260
cctcaaaccg gccgtttatc aaccgcctaa tggactactt gcatcgcgcg gccgccgtga 19320
accccgagta tttcaccaat gccatcttga acccgcactg gctaccgccc cctggtttct 19380
acaccggggg attcgaggtg cccgagggta acgatggatt cctctgggac gacatagacg 19440
acagcgtgtt ttccccgcaa ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag 19500
aggcggcgct gcgaaaggaa agcttccgca ggccaagcag cttgtccgat ctaggcgctg 19560
cggccccgcg gtcagatgct agtagcccat ttccaagctt gatagggtct cttaccagca 19620
ctcgcaccac ccgcccgcgc ctgctgggcg aggaggagta cctaaacaac tcgctgctgc 19680
agccgcagcg cgaaaaaaac ctgcctccgg catttcccaa caacgggata gagagcctag 19740
tggacaagat gagtagatgg aagacgtacg cgcaggagca cagggacgtg ccaggcccgc 19800
gcccgcccac ccgtcgtcaa aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg 19860
actcggcaga cgacagcagc gtcctggatt tgggagggag tggcaacccg tttgcgcacc 19920
ttcgccccag gctggggaga atgttttaaa aaaaaaaaag catgatgcaa aataaaaaac 19980
tcaccaaggc catggcaccg agcgttggtt ttcttgtatt ccccttagta tgcggcgcgc 20040
ggcgatgtat gaggaaggtc ctcctccctc ctacgagagt gtggtgagcg cggcgccagt 20100
ggcggcggcg ctgggttctc ccttcgatgc tcccctggac ccgccgtttg tgcctccgcg 20160
gtacctgcgg cctaccgggg ggagaaacag catccgttac tctgagttgg cacccctatt 20220
cgacaccacc cgtgtgtacc tggtggacaa caagtcaacg gatgtggcat ccctgaacta 20280
ccagaacgac cacagcaact ttctgaccac ggtcattcaa aacaatgact acagcccggg 20340
ggaggcaagc acacagacca tcaatcttga cgaccggtcg cactggggcg gcgacctgaa 20400
aaccatcctg cataccaaca tgccaaatgt gaacgagttc atgtttacca ataagtttaa 20460
ggcgcgggtg atggtgtcgc gcttgcctac taaggacaat caggtggagc tgaaatacga 20520
gtgggtggag ttcacgctgc ccgagggcaa ctactccgag accatgacca tagaccttat 20580
gaacaacgcg atcgtggagc actacttgaa agtgggcaga cagaacgggg ttctggaaag 20640
cgacatcggg gtaaagtttg acacccgcaa cttcagactg gggtttgacc ccgtcactgg 20700
tcttgtcatg cctggggtat atacaaacga agccttccat ccagacatca ttttgctgcc 20760
aggatgcggg gtggacttca cccacagccg cctgagcaac ttgttgggca tccgcaagcg 20820
gcaacccttc caggagggct ttaggatcac ctacgatgat ctggagggtg gtaacattcc 20880
cgcactgttg gatgtggacg cctaccaggc gagcttgaaa gatgacaccg aacagggcgg 20940
gggtggcgca ggcggcagca acagcagtgg cagcggcgcg gaagagaact ccaacgcggc 21000
agccgcggca atgcagccgg tggaggacat gaacgatcat gccattcgcg gcgacacctt 21060
tgccacacgg gctgaggaga agcgcgctga ggccgaagca gcggccgaag ctgccgcccc 21120
cgctgcgcaa cccgaggtcg agaagcctca gaagaaaccg gtgatcaaac ccctgacaga 21180
ggacagcaag aaacgcagtt acaacctaat aagcaatgac agcaccttca cccagtaccg 21240
cagctggtac cttgcataca actacggcga ccctcagacc ggaatccgct catggaccct 21300
gctttgcact cctgacgtaa cctgcggctc ggagcaggtc tactggtcgt tgccagacat 21360
gatgcaagac cccgtgacct tccgctccac gcgccagatc agcaactttc cggtggtggg 21420
cgccgagctg ttgcccgtgc actccaagag cttctacaac gaccaggccg tctactccca 21480
actcatccgc cagtttacct ctctgaccca cgtgttcaat cgctttcccg agaaccagat 21540
tttggcgcgc ccgccagccc ccaccatcac caccgtcagt gaaaacgttc ctgctctcac 21600
agatcacggg acgctaccgc tgcgcaacag catcggagga gtccagcgag tgaccattac 21660
tgacgccaga cgccgcacct gcccctacgt ttacaaggcc ctgggcatag tctcgccgcg 21720
cgtcctatcg agccgcactt tttgagcaag catgtccatc cttatatcgc ccagcaataa 21780
cacaggctgg ggcctgcgct tcccaagcaa gatgtttggc ggggccaaga agcgctccga 21840
ccaacaccca gtgcgcgtgc gcgggcacta ccgcgcgccc tggggcgcgc acaaacgcgg 21900
ccgcactggg cgcaccaccg tcgatgacgc catcgacgcg gtggtggagg aggcgcgcaa 21960
ctacacgccc acgccgccac cagtgtccac agtggacgcg gccattcaga ccgtggtgcg 22020
cggagcccgg cgctatgcta aaatgaagag acggcggagg cgcgtagcac gtcgccaccg 22080
ccgccgaccc ggcactgccg cccaacgcgc ggcggcggcc ctgcttaacc gcgcacgtcg 22140
caccggccga cgggcggcca tgcgggccgc tcgaaggctg gccgcgggta ttgtcactgt 22200
gccccccagg tccaggcgac gagcggccgc cgcagcagcc gcggccatta gtgctatgac 22260
tcagggtcgc aggggcaacg tgtattgggt gcgcgactcg gttagcggcc tgcgcgtgcc 22320
cgtgcgcacc cgccccccgc gcaactagat tgcaagaaaa aactacttag actcgtactg 22380
ttgtatgtat ccagcggcgg cggcgcgcaa cgaagctatg tccaagcgca aaatcaaaga 22440
agagatgctc caggtcatcg cgccggagat ctatggcccc ccgaagaagg aagagcagga 22500
ttacaagccc cgaaagctaa agcgggtcaa aaagaaaaag aaagatgatg atgatgaact 22560
tgacgacgag gtggaactgc tgcacgctac cgcgcccagg cgacgggtac agtggaaagg 22620
tcgacgcgta aaacgtgttt tgcgacccgg caccaccgta gtctttacgc ccggtgagcg 22680
ctccacccgc acctacaagc gcgtgtatga tgaggtgtac ggcgacgagg acctgcttga 22740
gcaggccaac gagcgcctcg gggagtttgc ctacggaaag cggcataagg acatgctggc 22800
gttgccgctg gacgagggca acccaacacc tagcctaaag cccgtaacac tgcagcaggt 22860
gctgcccgcg cttgcaccgt ccgaagaaaa gcgcggccta aagcgcgagt ctggtgactt 22920
ggcacccacc gtgcagctga tggtacccaa gcgccagcga ctggaagatg tcttggaaaa 22980
aatgaccgtg gaacctgggc tggagcccga ggtccgcgtg cggccaatca agcaggtggc 23040
gccgggactg ggcgtgcaga ccgtggacgt tcagataccc actaccagta gcaccagtat 23100
tgccaccgcc acagagggca tggagacaca aacgtccccg gttgcctcag cggtggcgga 23160
tgccgcggtg caggcggtcg ctgcggccgc gtccaagacc tctacggagg tgcaaacgga 23220
cccgtggatg tttcgcgttt cagccccccg gcgcccgcgc ggttcgagga agtacggcgc 23280
cgccagcgcg ctactgcccg aatatgccct acatccttcc attgcgccta cccccggcta 23340
tcgtggctac acctaccgcc ccagaagacg agcaactacc cgacgccgaa ccaccactgg 23400
aacccgccgc cgccgtcgcc gtcgccagcc cgtgctggcc ccgatttccg tgcgcagggt 23460
ggctcgcgaa ggaggcagga ccctggtgct gccaacagcg cgctaccacc ccagcatcgt 23520
ttaaaagccg gtctttgtgg ttcttgcaga tatggccctc acctgccgcc tccgtttccc 23580
ggtgccggga ttccgaggaa gaatgcaccg taggaggggc atggccggcc acggcctgac 23640
gggcggcatg cgtcgtgcgc accaccggcg gcggcgcgcg tcgcaccgtc gcatgcgcgg 23700
cggtatcctg cccctcctta ttccactgat cgccgcggcg attggcgccg tgcccggaat 23760
tgcatccgtg gccttgcagg cgcagagaca ctgattaaaa acaagttgca tgtggaaaaa 23820
tcaaaataaa aagtctggac tctcacgctc gcttggtcct gtaactattt tgtagaatgg 23880
aagacatcaa ctttgcgtct ctggccccgc gacacggctc gcgcccgttc atgggaaact 23940
ggcaagatat cggcaccagc aatatgagcg gtggcgcctt cagctggggc tcgctgtgga 24000
gcggcattaa aaatttcggt tccaccgtta agaactatgg cagcaaggcc tggaacagca 24060
gcacaggcca gatgctgagg gataagttga aagagcaaaa tttccaacaa aaggtggtag 24120
atggcctggc ctctggcatt agcggggtgg tggacctggc caaccaggca gtgcaaaata 24180
agattaacag taagcttgat ccccgccctc ccgtagagga gcctccaccg gccgtggaga 24240
cagtgtctcc agaggggcgt ggcgaaaagc gtccgcgccc cgacagggaa gaaactctgg 24300
tgacgcaaat agacgagcct ccctcgtacg aggaggcact aaagcaaggc ctgcccacca 24360
cccgtcccat cgcgcccatg gctaccggag tgctgggcca gcacacaccc gtaacgctgg 24420
acctgcctcc ccccgccgac acccagcaga aacctgtgct gccaggcccg accgccgttg 24480
ttgtaacccg tcctagccgc gcgtccctgc gccgcgccgc cagcggtccg cgatcgttgc 24540
ggcccgtagc cagtggcaac tggcaaagca cactgaacag catcgtgggt ctgggggtgc 24600
aatccctgaa gcgccgacga tgcttctgaa tagctaacgt gtcgtatgtg tgtcatgtat 24660
gcgtccatgt cgccgccaga ggagctgctg agccgccgcg cgcccgcttt ccaagatggc 24720
taccccttcg atgatgccgc agtggtctta catgcacatc tcgggccagg acgcctcgga 24780
gtacctgagc cccgggctgg tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa 24840
taacaagttt agaaacccca cggtggcgcc tacgcacgac gtgaccacag accggtccca 24900
gcgtttgacg ctgcggttca tccctgtgga ccgtgaggat actgcgtact cgtacaaggc 24960
gcggttcacc ctagctgtgg gtgataaccg tgtgctggac atggcttcca cgtactttga 25020
catccgcggc gtgctggaca ggggccctac ttttaagccc tactctggca ctgcctacaa 25080
cgccctggct cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct 25140
tgaaataaac ctagaagaag aggacgatga caacgaagac gaagtagacg agcaagctga 25200
gcagcaaaaa actcacgtat ttgggcaggc gccttattct ggtataaata ttacaaagga 25260
gggtattcaa ataggtgtcg aaggtcaaac acctaaatat gccgataaaa catttcaacc 25320
tgaacctcaa ataggagaat ctcagtggta cgaaactgaa attaatcatg cagctgggag 25380
agtccttaaa aagactaccc caatgaaacc atgttacggt tcatatgcaa aacccacaaa 25440
tgaaaatgga gggcaaggca ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt 25500
ggaaatgcaa tttttctcaa ctactgaggc gaccgcaggc aatggtgata acttgactcc 25560
taaagtggta ttgtacagtg aagatgtaga tatagaaacc ccagacactc atatttctta 25620
catgcccact attaaggaag gtaactcacg agaactaatg ggccaacaat ctatgcccaa 25680
caggcctaat tacattgctt ttagggacaa ttttattggt ctaatgtatt acaacagcac 25740
gggtaatatg ggtgttctgg cgggccaagc atcgcagttg aatgctgttg tagatttgca 25800
agacagaaac acagagcttt cataccagct tttgcttgat tccattggtg atagaaccag 25860
gtacttttct atgtggaatc aggctgttga cagctatgat ccagatgtta gaattattga 25920
aaatcatgga actgaagatg aacttccaaa ttactgcttt ccactgggag gtgtgattaa 25980
tacagagact cttaccaagg taaaacctaa aacaggtcag gaaaatggat gggaaaaaga 26040
tgctacagaa ttttcagata aaaatgaaat aagagttgga aataattttg ccatggaaat 26100
caatctaaat gccaacctgt ggagaaattt cctgtactcc aacatagcgc tgtatttgcc 26160
cgacaagcta aagtacagtc cttccaacgt aaaaatttct gataacccaa acacctacga 26220
ctacatgaac aagcgagtgg tggctcccgg gttagtggac tgctacatta accttggagc 26280
acgctggtcc cttgactata tggacaacgt caacccattt aaccaccacc gcaatgctgg 26340
cctgcgctac cgctcaatgt tgctgggcaa tggtcgctat gtgcccttcc acatccaggt 26400
gcctcagaag ttctttgcca ttaaaaacct ccttctcctg ccgggctcat acacctacga 26460
gtggaacttc aggaaggatg ttaacatggt tctgcagagc tccctaggaa atgacctaag 26520
ggttgacgga gccagcatta agtttgatag catttgcctt tacgccacct tcttccccat 26580
ggcccacaac accgcctcca cgcttgaggc catgcttaga aacgacacca acgaccagtc 26640
ctttaacgac tatctctccg ccgccaacat gctctaccct atacccgcca acgctaccaa 26700
cgtgcccata tccatcccct cccgcaactg ggcggctttc cgcggctggg ccttcacgcg 26760
ccttaagact aaggaaaccc catcactggg ctcgggctac gacccttatt acacctactc 26820
tggctctata ccctacctag atggaacctt ttacctcaac cacaccttta agaaggtggc 26880
cattaccttt gactcttctg tcagctggcc tggcaatgac cgcctgctta cccccaacga 26940
gtttgaaatt aagcgctcag ttgacgggga gggttacaac gttgcccagt gtaacatgac 27000
caaagactgg ttcctggtac aaatgctagc taactacaac attggctacc agggcttcta 27060
tatcccagag agctacaagg accgcatgta ctccttcttt agaaacttcc agcccatgag 27120
ccgtcaggtg gtggatgata ctaaatacaa ggactaccaa caggtgggca tcctacacca 27180
acacaacaac tctggatttg ttggctacct tgcccccacc atgcgcgaag gacaggccta 27240
ccctgctaac ttcccctatc cgcttatagg caagaccgca gttgacagca ttacccagaa 27300
aaagtttctt tgcgatcgca ccctttggcg catcccattc tccagtaact ttatgtccat 27360
gggcgcactc acagacctgg gccaaaacct tctctacgcc aactccgccc acgcgctaga 27420
catgactttt gaggtggatc ccatggacga gcccaccctt ctttatgttt tgtttgaagt 27480
ctttgacgtg gtccgtgtgc accggccgca ccgcggcgtc atcgaaaccg tgtacctgcg 27540
cacgcccttc tcggccggca acgccacaac ataaagaagc aagcaacatc aacaacagct 27600
gccgccatgg gctccagtga gcaggaactg aaagccattg tcaaagatct tggttgtggg 27660
ccatattttt tgggcaccta tgacaagcgc tttccaggct ttgtttctcc acacaagctc 27720
gcctgcgcca tagtcaatac ggccggtcgc gagactgggg gcgtacactg gatggccttt 27780
gcctggaacc cgcactcaaa aacatgctac ctctttgagc cctttggctt ttctgaccag 27840
cgactcaagc aggtttacca gtttgagtac gagtcactcc tgcgccgtag cgccattgct 27900
tcttcccccg accgctgtat aacgctggaa aagtccaccc aaagcgtaca ggggcccaac 27960
tcggccgcct gtggactatt ctgctgcatg tttctccacg cctttgccaa ctggccccaa 28020
actcccatgg atcacaaccc caccatgaac cttattaccg gggtacccaa ctccatgctc 28080
aacagtcccc aggtacagcc caccctgcgt cgcaaccagg aacagctcta cagcttcctg 28140
gagcgccact cgccctactt ccgcagccac agtgcgcaga ttaggagcgc cacttctttt 28200
tgtcacttga aaaacatgta aaaataatgt actagagaca ctttcaataa aggcaaatgc 28260
ttttatttgt acactctcgg gtgattattt acccccaccc ttgccgtctg cgccgtttaa 28320
aaatcaaagg ggttctgccg cgcatcgcta tgcgccactg gcagggacac gttgcgatac 28380
tggtgtttag tgctccactt aaactcaggc acaaccatcc gcggcagctc ggtgaagttt 28440
tcactccaca ggctgcgcac catcaccaac gcgtttagca ggtcgggcgc cgatatcttg 28500
aagtcgcagt tggggcctcc gccctgcgcg cgcgagttgc gatacacagg gttgcagcac 28560
tggaacacta tcagcgccgg gtggtgcacg ctggccagca cgctcttgtc ggagatcaga 28620
tccgcgtcca ggtcctccgc gttgctcagg gcgaacggag tcaactttgg tagctgcctt 28680
cccaaaaagg gcgcgtgccc aggctttgag ttgcactcgc accgtagtgg catcaaaagg 28740
tgaccgtgcc cggtctgggc gttaggatac agcgcctgca taaaagcctt gatctgctta 28800
aaagccacct gagcctttgc gccttcagag aagaacatgc cgcaagactt gccggaaaac 28860
tgattggccg gacaggccgc gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc 28920
accacatttc ggccccaccg gttcttcacg atcttggcct tgctagactg ctccttcagc 28980
gcgcgctgcc cgttttcgct cgtcacatcc atttcaatca cgtgctcctt atttatcata 29040
atgcttccgt gtagacactt aagctcgcct tcgatctcag cgcagcggtg cagccacaac 29100
gcgcagcccg tgggctcgtg atgcttgtag gtcacctctg caaacgactg caggtacgcc 29160
tgcaggaatc gccccatcat cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac 29220
ccgcggtgct cctcgttcag ccaggtcttg catacggccg ccagagcttc cacttggtca 29280
ggcagtagtt tgaagttcgc ctttagatcg ttatccacgt ggtacttgtc catcagcgcg 29340
cgcgcagcct ccatgccctt ctcccacgca gacacgatcg gcacactcag cgggttcatc 29400
accgtaattt cactttccgc ttcgctgggc tcttcctctt cctcttgcgt ccgcatacca 29460
cgcgccactg ggtcgtcttc attcagccgc cgcactgtgc gcttacctcc tttgccatgc 29520
ttgattagca ccggtgggtt gctgaaaccc accatttgta gcgccacatc ttctctttct 29580
tcctcgctgt ccacgattac ctctggtgat ggcgggcgct cgggcttggg agaagggcgc 29640
ttctttttct tcttgggcgc aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg 29700
ggtgtgcgcg gcaccagcgc gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc 29760
cgcctcatcc gcttttttgg gggcgcccgg ggaggcggcg gcgacgggga cggggacgac 29820
acgtcctcca tggttggggg acgtcgcgcc gcaccgcgtc cgcgctcggg ggtggtttcg 29880
cgctgctcct cttcccgact ggccatttcc ttctcctata ggcagaaaaa gatcatggag 29940
tcagtcgaga agaaggacag cctaaccgcc ccctctgagt tcgccaccac cgcctccacc 30000
gatgccgcca acgcgcctac caccttcccc gtcgaggcac ccccgcttga ggaggaggaa 30060
gtgattatcg agcaggaccc aggttttgta agcgaagacg acgaggaccg ctcagtacca 30120
acagaggata aaaagcaaga ccaggacaac gcagaggcaa acgaggaaca agtcgggcgg 30180
ggggacgaaa ggcatggcga ctacctagat gtgggagacg acgtgctgtt gaagcatctg 30240
cagcgccagt gcgccattat ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc 30300
atagcggatg tcagccttgc ctacgaacgc cacctattct caccgcgcgt accccccaaa 30360
cgccaagaaa acggcacatg cgagcccaac ccgcgcctca acttctaccc cgtatttgcc 30420
gtgccagagg tgcttgccac ctatcacatc tttttccaaa actgcaagat acccctatcc 30480
tgccgtgcca accgcagccg agcggacaag cagctggcct tgcggcaggg cgctgtcata 30540
cctgatatcg cctcgctcaa cgaagtgcca aaaatctttg agggtcttgg acgcgacgag 30600
aagcgcgcgg caaacgctct gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg 30660
ttggtggaac tcgagggtga caacgcgcgc ctagccgtac taaaacgcag catcgaggtc 30720
acccactttg cctacccggc acttaaccta ccccccaagg tcatgagcac agtcatgagt 30780
gagctgatcg tgcgccgtgc gcagcccctg gagagggatg caaatttgca agaacaaaca 30840
gaggagggcc tacccgcagt tggcgacgag cagctagcgc gctggcttca aacgcgcgag 30900
cctgccgact tggaggagcg acgcaaacta atgatggccg cagtgctcgt taccgtggag 30960
cttgagtgca tgcagcggtt ctttgctgac ccggagatgc agcgcaagct agaggaaaca 31020
ttgcactaca cctttcgaca gggctacgta cgccaggcct gcaagatctc caacgtggag 31080
ctctgcaacc tggtctccta ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg 31140
cttcattcca cgctcaaggg cgaggcgcgc cgcgactacg tccgcgactg cgtttactta 31200
tttctatgct acacctggca gacggccatg ggcgtttggc agcagtgctt ggaggagtgc 31260
aacctcaagg agctgcagaa actgctaaag caaaacttga aggacctatg gacggccttc 31320
aacgagcgct ccgtggccgc gcacctggcg gacatcattt tccccgaacg cctgcttaaa 31380
accctgcaac agggtctgcc agacttcacc agtcaaagca tgttgcagaa ctttaggaac 31440
tttatcctag agcgctcagg aatcttgccc gccacctgct gtgcacttcc tagcgacttt 31500
gtgcccatta agtaccgcga atgccctccg ccgctttggg gccactgcta ccttctgcag 31560
ctagccaact accttgccta ccactctgac ataatggaag acgtgagcgg tgacggtcta 31620
ctggagtgtc actgtcgctg caacctatgc accccgcacc gctccctggt ttgcaattcg 31680
cagctgctta acgaaagtca aattatcggt acctttgagc tgcagggtcc ctcgcctgac 31740
gaaaagtccg cggctccggg gttgaaactc actccggggc tgtggacgtc ggcttacctt 31800
cgcaaatttg tacctgagga ctaccacgcc cacgagatta ggttctacga agaccaatcc 31860
cgcccgccaa atgcggagct taccgcctgc gtcattaccc agggccacat tcttggccaa 31920
ttgcaagcca tcaacaaagc ccgccaagag tttctgctac gaaagggacg gggggtttac 31980
ttggaccccc agtccggcga ggagctcaac ccaatccccc cgccgccgca gccctatcag 32040
cagcagccgc gggcccttgc ttcccaggat ggcacccaaa aagaagctgc agctgccgcc 32100
gccacccacg gacgaggagg aatactggga cagtcaggca gaggaggttt tggacgagga 32160
ggaggaggac atgatggaag actgggagag cctagacgag gaagcttccg aggtcgaaga 32220
ggtgtcagac gaaacaccgt caccctcggt cgcattcccc tcgccggcgc cccagaaatc 32280
ggcaaccggt tccagcatgg ctacaacctc cgctcctcag gcgccgccgg cactgcccgt 32340
tcgccgaccc aaccgtagat gggacaccac tggaaccagg gccggtaagt ccaagcagcc 32400
gccgccgtta gcccaagagc aacaacagcg ccaaggctac cgctcatggc gcgggcacaa 32460
gaacgccata gttgcttgct tgcaagactg tgggggcaac atctccttcg cccgccgctt 32520
tcttctctac catcacggcg tggccttccc ccgtaacatc ctgcattact accgtcatct 32580
ctacagccca tactgcaccg gcggcagcgg cagcggcagc aacagcagcg gccacacaga 32640
agcaaaggcg accggatagc aagactctga caaagcccaa gaaatccaca gcggcggcag 32700
cagcaggagg aggagcgctg cgtctggcgc ccaacgaacc cgtatcgacc cgcgagctta 32760
gaaacaggat ttttcccact ctgtatgcta tatttcaaca gagcaggggc caagaacaag 32820
agctgaaaat aaaaaacagg tctctgcgat ccctcacccg cagctgcctg tatcacaaaa 32880
gcgaagatca gcttcggcgc acgctggaag acgcggaggc tctcttcagt aaatactgcg 32940
cgctgactct taaggactag tttcgcgccc tttctcaaat ttaagcgcga aaactacgtc 33000
atctccagcg gccacacccg gcgccagcac ctgtcgtcag cgccattatg agcaaggaaa 33060
ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 33120
aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 33180
acggaatccg cgcccaccga aaccgaattc tcttggaaca ggcggctatt accaccacac 33240
ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 33300
ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 33360
gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 33420
acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 33480
gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgtccttca ttcacgcctc 33540
gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 33600
ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 33660
ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 33720
gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 33780
gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 33840
aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 33900
gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 33960
gtgttctcac tgtgatttgc aactgtccta accttggatt acatcaagat ctttgttgcc 34020
atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 34080
cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 34140
tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 34200
gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 34260
gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 34320
tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 34380
cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 34440
tacgggctat tctaattcag gtttctctag aaatggacgg aattattaca gagcagcgcc 34500
tgctagaaag acgcagggca gcggccgagc aacagcgcat gaatcaagag ctccaagaca 34560
tggttaactt gcaccagtgc aaaaggggta tcttttgtct ggtaaagcag gccaaagtca 34620
cctacgacag taataccacc ggacaccgcc ttagctacaa gttgccaacc aagcgtcaga 34680
aattggtggt catggtggga gaaaagccca ttaccataac tcagcactcg gtagaaaccg 34740
aaggctgcat tcactcacct tgtcaaggac ctgaggatct ctgcaccctt attaagaccc 34800
tgtgcggtct caaagatctt attcccttta actaataaaa aaaaataata aagcatcact 34860
tacttaaaat cagttagcaa atttctgtcc agtttattca gcagcacctc cttgccctcc 34920
tcccagctct ggtattgcag cttcctcctg gctgcaaact ttctccacaa tctaaatgga 34980
atgtcagttt cctcctgttc ctgtccatcc gcacccacta tcttcatgtt gttgcagatg 35040
aagcgcgcaa gaccgtctga agataccttc aaccccgtgt atccatatga cacggaaacc 35100
ggtcctccaa ctgtgccttt tcttactcct ccctttgtat cccccaatgg gtttcaagag 35160
agtccccctg gggtactctc tttgcgccta tccgaacctc tagttacctc caatggcatg 35220
cttgcgctca aaatgggcaa cggcctctct ctggacgagg ccggcaacct tacctcccaa 35280
aatgtaacca ctgtgagccc acctctcaaa aaaaccaagt caaacataaa cctggaaata 35340
tctgcacccc tcacagttac ctcagaagcc ctaactgtgg ctgccgccgc acctctaatg 35400
gtcgcgggca acacactcac catgcaatca caggccccgc taaccgtgca cgactccaaa 35460
cttagcattg ccacccaagg acccctcaca gtgtcagaag gaaagctagc cctgcaaaca 35520
tcaggccccc tcaccaccac cgatagcagt acccttacta tcactgcctc accccctcta 35580
actactgcca ctggtagctt gggcattgac ttgaaagagc ccatttatac acaaaatgga 35640
aaactaggac taaagtacgg ggctcctttg catgtaacag acgacctaaa cactttgacc 35700
gtagcaactg gtccaggtgt gactattaat aatacttcct tgcaaactaa agttactgga 35760
gccttgggtt ttgattcaca aggcaatatg caacttaatg tagcaggagg actaaggatt 35820
gattctcaaa acagacgcct tatacttgat gttagttatc cgtttgatgc tcaaaaccaa 35880
ctaaatctaa gactaggaca gggccctctt tttataaact cagcccacaa cttggatatt 35940
aactacaaca aaggccttta cttgtttaca gcttcaaaca attccaaaaa gcttgaggtt 36000
aacctaagca ctgccaaggg gttgatgttt gacgctacag ccatagccat taatgcagga 36060
gatgggcttg aatttggttc acctaatgca ccaaacacaa atcccctcaa aacaaaaatt 36120
ggccatggcc tagaatttga ttcaaacaag gctatggttc ctaaactagg aactggcctt 36180
agttttgaca gcacaggtgc cattacagta ggaaacaaaa ataatgataa gctaactttg 36240
tggaccacac cagctccatc tcctaactgt agactaaatg cagagaaaga tgctaaactc 36300
actttggtct taacaaaatg tggcagtcaa atacttgcta cagtttcagt tttggctgtt 36360
aaaggcagtt tggctccaat atctggaaca gttcaaagtg ctcatcttat tataagattt 36420
gacgaaaatg gagtgctact aaacaattcc ttcctggacc cagaatattg gaactttaga 36480
aatggagatc ttactgaagg cacagcctat acaaacgctg ttggatttat gcctaaccta 36540
tcagcttatc caaaatctca cggtaaaact gccaaaagta acattgtcag tcaagtttac 36600
ttaaacggag acaaaactaa acctgtaaca ctaaccatta cactaaacgg tacacaggaa 36660
acaggagaca caactccaag tgcatactct atgtcatttt catgggactg gtctggccac 36720
aactacatta atgaaatatt tgccacatcc tcttacactt tttcatacat tgcccaagaa 36780
taaagaatcg tttgtgttat gtttcaacgt gtttattttt caattgcaga aaatttcgaa 36840
tcatttttca ttcagtagta tagccccacc accacatagc ttatacagat caccgtacct 36900
taatcaaact cacagaaccc tagtattcaa cctgccacct ccctcccaac acacagagta 36960
cacagtcctt tctccccggc tggccttaaa aagcatcata tcatgggtaa cagacatatt 37020
cttaggtgtt atattccaca cggtttcctg tcgagccaaa cgctcatcag tgatattaat 37080
aaactccccg ggcagctcac ttaagttcat gtcgctgtcc agctgctgag ccacaggctg 37140
ctgtccaact tgcggttgct taacgggcgg cgaaggagaa gtccacgcct acatgggggt 37200
agagtcataa tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc gaataaactg 37260
ctgccgccgc cgctccgtcc tgcaggaata caacatggca gtggtctcct cagcgatgat 37320
tcgcaccgcc cgcagcataa ggcgccttgt cctccgggca cagcagcgca ccctgatctc 37380
acttaaatca gcacagtaac tgcagcacag caccacaata ttgttcaaaa tcccacagtg 37440
caaggcgctg tatccaaagc tcatggcggg gaccacagaa cccacgtggc catcatacca 37500
caagcgcagg tagattaagt ggcgacccct cataaacacg ctggacataa acattacctc 37560
ttttggcatg ttgtaattca ccacctcccg gtaccatata aacctctgat taaacatggc 37620
gccatccacc accatcctaa accagctggc caaaacctgc ccgccggcta tacactgcag 37680
ggaaccggga ctggaacaat gacagtggag agcccaggac tcgtaaccat ggatcatcat 37740
gctcgtcatg atatcaatgt tggcacaaca caggcacacg tgcatacact tcctcaggat 37800
tacaagctcc tcccgcgtta gaaccatatc ccagggaaca acccattcct gaatcagcgt 37860
aaatcccaca ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt 37920
acattcgggc agcagcggat gatcctccag tatggtagcg cgggtttctg tctcaaaagg 37980
aggtagacga tccctactgt acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag 38040
tgtcatgcca aatggaacgc cggacgtagt catatttcct gaagcaaaac caggtgcggg 38100
cgtgacaaac agatctgcgt ctccggtctc gccgcttaga tcgctctgtg tagtagttgt 38160
agtatatcca ctctctcaaa gcatccaggc gccccctggc ttcgggttct atgtaaactc 38220
cttcatgcgc cgctgccctg ataacatcca ccaccgcaga ataagccaca cccagccaac 38280
ctacacattc gttctgcgag tcacacacgg gaggagcggg aagagctgga agaaccatgt 38340
tttttttttt attccaaaag attatccaaa acctcaaaat gaagatctat taagtgaacg 38400
cgctcccctc cggtggcgtg gtcaaactct acagccaaag aacagataat ggcatttgta 38460
agatgttgca caatggcttc caaaaggcaa acggccctca cgtccaagtg gacgtaaagg 38520
ctaaaccctt cagggtgaat ctcctctata aacattccag caccttcaac catgcccaaa 38580
taattctcat ctcgccacct tctcaatata tctctaagca aatcccgaat attaagtccg 38640
gccattgtaa aaatctgctc cagagcgccc tccaccttca gcctcaagca gcgaatcatg 38700
attgcaaaaa ttcaggttcc tcacagacct gtataagatt caaaagcgga acattaacaa 38760
aaataccgcg atcccgtagg tcccttcgca gggccagctg aacataatcg tgcaggtctg 38820
cacggaccag cgcggccact tccccgccag gaaccttgac aaaagaaccc acactgatta 38880
tgacacgcat actcggagct atgctaacca gcgtagcccc gatgtaagct ttgttgcatg 38940
ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa 39000
gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca 39060
gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa 39120
aataacaaaa aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta 39180
taagcataag acggactacg gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat 39240
taaaaagcac caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa 39300
acacatcagg ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa 39360
tacatacccg caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa 39420
taggagagaa aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct 39480
cccgctccag aacaacatac agcgcttcca cagcggcagc cataacagtc agccttacca 39540
gtaaaaaaga aaacctatta aaaaaacacc actcgacacg gcaccataac ttcgtatagc 39600
atacattata cgaagttata gctcaatcag tcacagtgta aaaaagggcc aagtgcagag 39660
cgagtatata taggactaaa aaatgacgta acggttaaag tccacaaaaa acacccagaa 39720
aaccgcacgc gaacctacgc ccagaaacga aagccaaaaa acccacaact tcctcaaatc 39780
gtcacttccg ttttcccacg ttacgtcact tcccatttta agaaaactac aattcccaac 39840
acatacaagt tactccgccc taaaacctac gtcacccgcc ccgttcccac gccccgcgcc 39900
acgtcacaaa ctccaccccc tcattatcat attggcttca atccaaaata aggtatatta 39960
ttgatgatgc caaggaattt gccggggtcc actgcaatta ataacttcgt atagcataca 40020
ttatacgaag ttatttaatt aagggcggcc gcacgggcca tcgatgggga tcctaacttt 40080
aaataatgcc aattatttaa agttaatccg cggagaagct tctcgaccaa ttctcatgtt 40140
tgacagctta tcatcgaatt tctgccattc atccgcttat tatcacttat tcaggcgtag 40200
caaccaggcg tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac 40260
tcatcgcagt actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg 40320
gcatgatgaa cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg 40380
cccatggtga aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg 40440
gtgaaactca cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg 40500
aaataggcca ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc 40560
cggaaatcgt cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa 40620
acggtgtaac aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata 40680
cggaattccg gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac 40740
ttgtgcttat ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg 40800
ttataggtac attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg 40860
gatatatcaa cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct 40920
gaaaatctcg ataactcaaa aaatacgccc g 40951
<210> 57
<211> 38053
<212> DNA
<213> 人工序列
<220>
<223> pBWH-E4-DE3
<400> 57
ttaattaatc aactaacccc ttaccccatt acccatccag taaaaaaaat aaagattaaa 60
gagacgatga ttttgaattg atcaataaag aatcacttac ttgaaatctg aaaccaggtc 120
tctgtccatg ttttctgtca gcagcacttc gctcccctct tcccagctct ggtactgcag 180
gccccggcgg gctgcaaact tcctccacac tctgaagggg atgtcaaatt cctcctgtcc 240
ctcaatcttc attttttatt tctattagat gtccaaaaag cgcgcgcggg tggatgatgg 300
cttcgacccc gtgtatccct acgatgcaga caacgcaccg accgtgccct tcatcaaccc 360
tcccttcgtc tcttcagatg gattccaaga aaagcccctg ggggtgttgt cccttaggct 420
ggccgaccct gtcaccacca agaatgggga aattaccctc aagctggggg agggggtgga 480
ccttgacgac tcgggaaaac tcattgcaaa cacagtaaac aaggccattg cccctctcag 540
tttttccaac aacaccattt cccttaacat ggatacccct ttatacacca aagatggaaa 600
actatcctta caagtttctc caccattaag tatattaaaa tcaacaattt tgaatacatt 660
agctctagct tttggctcag gtttaggact cagtggcagc gccctggcag tacagttagc 720
ctctccactt acatttgatg ataaagggaa tataaagatt accctaaaca ggggattgca 780
tgttacaaca ggagatgcaa ttgaaagcaa catcagttgg gctaaaggta taaaatttga 840
agatggtgcc atagctacaa acattggtaa ggggctagag ttcggaacca gtagtacaga 900
aacaggagtt aataatgctt atccaatcca agttaaactt ggctctggtc tcagctttga 960
cagcacagga gccataatgg ctggcaataa agactatgat aaattaactt tgtggacaac 1020
gcctgaccca tcaccaaact gtcaaatact tgcagaaaat gatgcaaaac taacactttg 1080
cttaactaag tgtgacagtc aaatactggc cactgtatca gttttggttg ttagaagtgg 1140
aaacttaaac ccaattactg gcacagtaag cagtgctcaa gtttttctac gttttgatgc 1200
aaatggtgtt cttttaacag aacactctac actaaaaaaa tactggggct acaagcaagg 1260
agatagcata gatggcactc catacaccaa tgctgttggt tttatgccaa attcaacagc 1320
ttatccaaag acccaaagtt ctactactaa aaataatata gtgggtcaag tatacatgaa 1380
tggagatgtt tcaaaaccca tgcttcttac tataactctt aatggtactg atgacaccac 1440
cagtgcatac tcaatgtcat tttcatacac ctggactaac ggaagctata tcggagcaac 1500
atttggagct aactcataca ccttctccta catagcccaa caataatccc accctgcatg 1560
ccaacccacc ttttccctct atttataaat ggaaactgaa acaaaaataa agttcaagtg 1620
ttttattgat tcaacagttt ttcacaggat tcgagtagtt attttccctc caccctccca 1680
tctcatggaa tacactatcc tctccccacg cacagcctta aacatctgaa tgctattggt 1740
aatggacatg gttttgatct ccacattcca cacagtttca gagcgagaca gtctcgggtc 1800
ggtcaaggag atgaaaccct ccgggcactc ctgcatctgc acctcacagt tcaacagctg 1860
agggctgtcc tcggtgattg gaatcacagt tatctggaat aagagcgatg agaatcataa 1920
tccgcaaacg ggatcgggcg gttgtggcgc atcaggcccc gcagcagtcg ctgtctgcgc 1980
cgctccgtca agctgctact caaggggtcc gggtccaggg actccctgcg catgatgcca 2040
atggccctga gcatcagtcg cctggtacgg cgggcgcagc agcggatgcg gatctcactc 2100
aggtcggagc agtacgtgca gcacagcacc accaagttgt tcaacagtcc atagttcaac 2160
gtgctccagc caaaactcat ttgtggaact atgctgccca catgtccatc gtaccagatc 2220
ctgatgtaaa tcaggtggcg tcccctccag aacacactgc ccatgtacat gatctccttg 2280
ggcatgtgca ggttcaccac ctcccggtac cacatcaccc gctggttgaa catgcagccc 2340
tggataattc tgcggaacca gatggcaagt accgtcccgc ccgccatgca gcgcagggac 2400
cccgggttct ggcaatggca gtggatcacc caccgctcgc gaccgtggat caactgggaa 2460
ctaaacaagt ctatgttggc acagcacagg cacacgctca tgcatgtctt cagcactctc 2520
aattcctcgg gggtcaggac catatcccag ggcacaggga actcttgcag gacagtgaac 2580
ccggccgaac agggcaatcc tcgcacggaa cttacattgt gcatggacag ggtatcgcaa 2640
tcaggcagca ccggatgatc ctccaccaga gaagcgcggc tctcggtctc ctcacagcga 2700
ggtaaggtgg ccggcggttg gtacggatga tggcgagata acgctaatcg tgttctggat 2760
cgtgtcatga tggagctgtt tccggacatt ttcgtatttc acaaagcaga acctggtccg 2820
ggcactgcac accgctcgtc ggcgacggtc tcggcgcttc gagcgctcaa tgttgaagtt 2880
atagaacagc cactccctca gaacgtgcag tatctcctga gcctcttggg tgatgaaaat 2940
cccatccgcc ctgatggctc tgattacatc aaccacggtg gaatgggcca aacccagcca 3000
gatgatgcaa ttttgttggg tttcggtgac ggcgggggag ggaagaacag gaagaaccat 3060
gattaacttt attccaaacg gtctcggaac acttcaaaat gcaggtcccg gaggtggcac 3120
ctctcgcccc cactgtgttg gtggaaaata acagccaggt caaaggtaac acggttctcg 3180
agatgttcca cggtggcttc cagcaaagcc tccacgcgca catccagaaa caagaggaca 3240
gcgaaagcgg gagcgttttc taattcctca atcatcatat tacactcctg caccatgcct 3300
agataatttt catttttcca gccttgaatg attcgtatta gttcctgagg taaatccaag 3360
ccagccatga taaaaagctc gcgcagagcg ccctccaccg gcattcttaa gcacaccctc 3420
ataattccaa cagattctgc tcctggttca cctgtagtag attaacaagt ggaatatcaa 3480
ttgctctgcc gcaatcccta agctcctccc ttagcagtaa ctgtatgtac tcattcatat 3540
cttctccgaa atttttagcc ataggaccac caggaacaag agaagggcaa gccacattac 3600
agataaagcg aagtcctccc cagtgagcat tgccaaatgt aagattgaaa taagcatgct 3660
ggctagaccc ggtgatatct tccagataac tggacagaaa atcaggcaag caatttttaa 3720
gaaaattaac aaaagaaaag tcgtctaggt gcacgtttag agcctcagga acaacgatgg 3780
aataagtgca aggagtacgt tccagcatgg ttagtgtttt tggtgatctg tagaacaaaa 3840
aataaacatg caatattaaa ccatgctagc ctggcgaaca ggtggataaa tcactctttc 3900
caacaccagg caggctacag ggtctccggc gcgaccattg tagaagctga cattatgatt 3960
aaaaagcatc accgacagac cttcccggtg gccggcatgg atgattcgag aagaagcata 4020
cactccggga acattggcgt ccgtgagtga aaaaaagcga cctataaagc cttgaggcac 4080
tacaatgctt aatcttaatt ccagcaaagc gaccccatgc ggatgaagca caaaattggc 4140
aggtgcgtaa aaaatgtaat tactcccctt ctgcacaggc agcaaagccc ccgctccctc 4200
cagaaacaca tacaaaacct gagcgtccat agcttaccga gcacggcagg cgcaagagtc 4260
agagaaaaag ctgagctcta acctaactgc ccgcttctgt actcaatata tagccctaac 4320
ctcactgacg taaaggccaa ggtctaaaaa tacccgccaa cacgcccaga aaccggtgac 4380
acactaaaaa aatacgtgca cttcctcaaa cgcccaaact ggcgtcattt ccggtttccc 4440
acgctacgtc acctctcaac gactttcaaa ttccgtcgac cgttaaacac atcagttacc 4500
ccgcccctaa cgaacgccgc tgtcacagcc aatcagcgcg ccccatcccc aaattttcac 4560
gccttatttg catattaact cacacaaaaa aaataaggta tattatatag atagcctccg 4620
gggtccactg caattacttc tcgaccaatt ctcatgtttg acagcttatc atcgaatttc 4680
tgccattcat ccgcttatta tcacttattc aggcgtagca accaggcgtt taagggcacc 4740
aataactgcc ttaaaaaaat tacgccccgc cctgccactc atcgcagtac tgttgtaatt 4800
cattaagcat tctgccgaca tggaagccat cacagacggc atgatgaacc tgaatcgcca 4860
gcggcatcag caccttgtcg ccttgcgtat aatatttgcc catggtgaaa acgggggcga 4920
agaagttgtc catattggcc acgtttaaat caaaactggt gaaactcacc cagggattgg 4980
ctgagacgaa aaacatattc tcaataaacc ctttagggaa ataggccagg ttttcaccgt 5040
aacacgccac atcttgcgaa tatatgtgta gaaactgccg gaaatcgtcg tggtattcac 5100
tccagagcga tgaaaacgtt tcagtttgct catggaaaac ggtgtaacaa gggtgaacac 5160
tatcccatat caccagctca ccgtctttca ttgccatacg gaattccgga tgagcattca 5220
tcaggcgggc aagaatgtga ataaaggccg gataaaactt gtgcttattt ttctttacgg 5280
tctttaaaaa ggccgtaata tccagctgaa cggtctggtt ataggtacat tgagcaactg 5340
actgaaatgc ctcaaaatgt tctttacgat gccattggga tatatcaacg gtggtatatc 5400
cagtgatttt tttctccatt ttagcttcct tagctcctga aaatctcgat aactcaaaaa 5460
atacgcccgg tagtgatctt atttcattat ggtgaaagtt ggaacctctt acgtgccgat 5520
caacgtctca ttttcgccaa aagttggccc agggcttccc ggtatcaaca gggacaccag 5580
gatttattta ttctgcgaag tgatcttccg tcacaggtat ttattcgcga taagctcatg 5640
gagcggcgta accgtcgcac aggaaggaca gagaaagcgc ggatctggga agtgacggac 5700
agaacggtca ggacctggat tggggaggcg gttgccgccg ctgctgctga cggtgtgacg 5760
ttctctgttc cggtcacacc acatacgttc cgccattcct atgcgatgca catgctgtat 5820
gccggtatac cgctgaaagt tctgcaaagc ctgatgggac ataagtccat cagttcaacg 5880
gaagtctaca cgaaggtttt tgcgctggat gtggctgccc ggcaccgggt gcagtttgcg 5940
atgccggagt ctgatgcggt tgcgatgctg aaacaattat cctgagaata aatgccttgg 6000
cctttatatg gaaatgtgga actgagtgga tatgctgttt ttgtctgtta aacagagaag 6060
ctggctgtta tccactgaga agcgaacgaa acagtcggga aaatctccca ttatcgtaga 6120
gatccgcatt attaatctca ggagcctgtg tagcgtttat aggaagtagt gttctgtcat 6180
gatgcctgca agcggtaacg aaaacgattt gaatatgcct tcaggaacaa tagaaatctt 6240
cgtgcggtgt tacgttgaag tggagcggat tatgtcagca atggacagaa caacctaatg 6300
aacacagaac catgatgtgg tctgtccttt tacagccagt aggctcgccg cagtcgagcg 6360
acggcgaagc cctcgagtga gcgaggaagc accagggaac agcacttata tattctgctt 6420
acacacgatg cctgaaaaaa cttcccttgg ggttatccac ttatccacgg ggatattttt 6480
ataattattt tttttatagt ttttagatct tcttttttag agcgccttgt aggcctttat 6540
ccatgctggt tctagagaag gtgttgtgac aaattgccct ttcagtgtga caaatcaccc 6600
tcaaatgaca gtcctgtctg tgacaaattg cccttaaccc tgtgacaaat tgccctcaga 6660
agaagctgtt ttttcacaaa gttatccctg cttattgact cttttttatt tagtgtgaca 6720
atctaaaaac ttgtcacact tcacatggat ctgtcatggc ggaaacagcg gttatcaatc 6780
acaagaaacg taaaaatagc ccgcgaatcg tccagtcaaa cgacctcact gaggcggcat 6840
atagtctctc ccgggatcaa aaacgtatgc tgtatctgtt cgttgaccag atcagaaaat 6900
ctgatggcac cctacaggaa catgacggta tctgcgagat ccatgttgct aaatatgctg 6960
aaatattcgg attgacctct gcggaagcca gtaaggatat acggcaggca ttgaagagtt 7020
tcgcggggaa ggaagtggtt ttttatcgcc ctgaagagga tgccggcgat gaaaaaggct 7080
atgaatcttt tccttggttt atcaaacgtg cgcacagtcc atccagaggg ctttacagtg 7140
tacatatcaa cccatatctc attcccttct ttatcgggtt acagaaccgg tttacgcagt 7200
ttcggcttag tgaaacaaaa gaaatcacca atccgtatgc catgcgttta tacgaatccc 7260
tgtgtcagta tcgtaagccg gatggctcag gcatcgtctc tctgaaaatc gactggatca 7320
tagagcgtta ccagctgcct caaagttacc agcgtatgcc tgacttccgc cgccgcttcc 7380
tgcaggtctg tgttaatgag atcaacagca gaactccaat gcgcctctca tacattgaga 7440
aaaagaaagg ccgccagacg actcatatcg tattttcctt ccgcgatatc acttccatga 7500
cgacaggata gtctgagggt tatctgtcac agatttgagg gtggttcgtc acatttgttc 7560
tgacctactg agggtaattt gtcacagttt tgctgtttcc ttcagcctgc atggattttc 7620
tcatactttt tgaactgtaa tttttaagga agccaaattt gagggcagtt tgtcacagtt 7680
gatttccttc tctttccctt cgtcatgtga cctgatatcg ggggttagtt cgtcatcatt 7740
gatgagggtt gattatcaca gtttattact ctgaattggc tatccgcgtg tgtacctcta 7800
cctggagttt ttcccacggt ggatatttct tcttgcgctg agcgtaagag ctatctgaca 7860
gaacagttct tctttgcttc ctcgccagtt cgctcgctat gctcggttac acggctgcgg 7920
cgagcgctag tgataataag tgactgaggt atgtgctctt cttatctcct tttgtagtgt 7980
tgctcttatt ttaaacaact ttgcggtttt ttgatgactt tgcgattttg ttgttgcttt 8040
gcagtaaatt gcaagattta ataaaaaaac gcaaagcaat gattaaagga tgttcagaat 8100
gaaactcatg gaaacactta accagtgcat aaacgctggt catgaaatga cgaaggctat 8160
cgccattgca cagtttaatg atgacagccc ggaagcgagg aaaataaccc ggcgctggag 8220
aataggtgaa gcagcggatt tagttggggt ttcttctcag gctatcagag atgccgagaa 8280
agcagggcga ctaccgcacc cggatatgga aattcgagga cgggttgagc aacgtgttgg 8340
ttatacaatt gaacaaatta atcatatgcg tgatgtgttt ggtacgcgat tgcgacgtgc 8400
tgaagacgta tttccaccgg tgatcggggt tgctgcccat aaaggtggcg tttacaaaac 8460
ctcagtttct gttcatcttg ctcaggatct ggctctgaag gggctacgtg ttttgctcgt 8520
ggaaggtaac gacccccagg gaacagcctc aatgtatcac ggatgggtac cagatcttca 8580
tattcatgca gaagacactc tcctgccttt ctatcttggg gaaaaggacg atgtcactta 8640
tgcaataaag cccacttgct ggccggggct tgacattatt ccttcctgtc tggctctgca 8700
ccgtattgaa actgagttaa tgggcaaatt tgatgaaggt aaactgccca ccgatccaca 8760
cctgatgctc cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga 8820
cagcgcgcct aacctgggta tcggcacgat taatgtcgta tgtgctgctg atgtgctgat 8880
tgttcccacg cctgctgagt tgtttgacta cacctccgca ctgcagtttt tcgatatgct 8940
tcgtgatctg ctcaagaacg ttgatcttaa agggttcgag cctgatgtac gtattttgct 9000
taccaaatac agcaatagta atggctctca gtccccgtgg atggaggagc aaattcggga 9060
tgcctgggga agcatggttc taaaaaatgt tgtacgtgaa acggatgaag ttggtaaagg 9120
tcagatccgg atgagaactg tttttgaaca ggccattgat caacgctctt caactggtgc 9180
ctggagaaat gctctttcta tttgggaacc tgtctgcaat gaaattttcg atcgtctgat 9240
taaaccacgc tgggagatta gataatgaag cgtgcgcctg ttattccaaa acatacgctc 9300
aatactcaac cggttgaaga tacttcgtta tcgacaccag ctgccccgat ggtggattcg 9360
ttaattgcgc gcgtaggagt aatggctcgc ggtaatgcca ttactttgcc tgtatgtggt 9420
cgggatgtga agtttactct tgaagtgctc cggggtgata gtgttgagaa gacctctcgg 9480
gtatggtcag gtaatgaacg tgaccaggag ctgcttactg aggacgcact ggatgatctc 9540
atcccttctt ttctactgac tggtcaacag acaccggcgt tcggtcgaag agtatctggt 9600
gtcatagaaa ttgccgatgg gagtcgccgt cgtaaagctg ctgcacttac cgaaagtgat 9660
tatcgtgttc tggttggcga gctggatgat gagcagatgg ctgcattatc cagattgggt 9720
aacgattatc gcccaacaag tgcttatgaa cgtggtcagc gttatgcaag ccgattgcag 9780
aatgaatttg ctggaaatat ttctgcgctg gctgatgcgg aaaatatttc acgtaagatt 9840
attacccgct gtatcaacac cgccaaattg cctaaatcag ttgttgctct tttttctcac 9900
cccggtgaac tatctgcccg gtcaggtgat gcacttcaaa aagcctttac agataaagag 9960
gaattactta agcagcaggc atctaacctt catgagcaga aaaaagctgg ggtgatattt 10020
gaagctgaag aagttatcac tcttttaact tctgtgctta aaacgtcatc tgcatcaaga 10080
actagtttaa gctcacgaca tcagtttgct cctggagcga cagtattgta taagggcgat 10140
aaaatggtgc ttaacctgga caggtctcgt gttccaactg agtgtataga gaaaattgag 10200
gccattctta aggaacttga aaagccagca ccctgatgcg accacgtttt agtctacgtt 10260
tatctgtctt tacttaatgt cctttgttac aggccagaaa gcataactgg cctgaatatt 10320
ctctctgggc ccactgttcc acttgtatcg tcggtctgat aatcagactg ggaccacggt 10380
cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg 10440
tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgata atcagactgg 10500
gaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccatg gtcccactcg 10560
tatcgtcggt ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgatta 10620
ttagtctgga accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg 10680
tcccactcgt atcgtcggtc tgattattag tctgggacca cgatcccact cgtgttgtcg 10740
gtctgattat cggtctggga ccacggtccc acttgtattg tcgatcagac tatcagcgtg 10800
agactacgat tccatcaatg cctgtcaagg gcaagtattg acatgtcgtc gtaacctgta 10860
gaacggagta acctcggtgt gcggttgtat gcctgctgtg gattgctgct gtgtcctgct 10920
tatccacaac attttgcgca cggttatgtg gacaaaatac ctggttaccc aggccgtgcc 10980
ggcacgttaa ccgggctgca tccgatgcaa gtgtgtcgct gtcgagttta taattgcagt 11040
ggaccccgga ggctatctat ataatatacc ttattttttt tgtgtgagtt aatatgcaaa 11100
taaggcgtga aaatttgggg atggggcgcg ctgattggct gtgacagcgg cgttcgttag 11160
gggcggggca ggtgacgttt tgatgacgcg actatgagga ggagttagtt tgcaagttct 11220
ggtggggaaa agtgacgtca aacgaggtgt ggtttaaaca cggaaatact caattttccc 11280
acgctgtcta acaggaaatg aggtgttttt gggcggatgc aagtgaaaac ggaccatttt 11340
cgcgcgaaaa ctgaatgagg aagtgaaatc tgagtaattt agtgtttatg acagggagga 11400
gtatttgccg agggccgagt agactttgac cgtttacgtg ggggtttcga ttaccgtgtt 11460
tttcacctaa agttccgcgt acggtgtcaa agtccggtgt ttttacgtag gtgtcagctg 11520
atcgtcaggg tatttaaacc tgcgctctgc agtcaagagg ccactcttga gtgccagcga 11580
gaagagtttt ctcctccgcg ccgcgagtca gatctacact ttgaaatatg aggcacctaa 11640
gagacctgcc cgatgaggaa attatcatcg cttccgggag cgagattctg gaactggtgg 11700
taaatgctat gatgggcgac gaccatccgg aaccccccac cccatttgag acaccttcgc 11760
tgcacgattt gtatgatctg gaggtggatg tgcccgagga cgaccccaac gagaaggcgg 11820
taaatgattt atttagcgat gccgcgctgc tagctgccga ggaggcttca agccctagct 11880
cagacagcga ctcttcactg cataccccta gacacgacag aggtgagaaa gagatccccg 11940
ggcttaaatg ggaaaagatg gacttgcgtt gctatgagga atgcctgccc ccaagcgatg 12000
atgaggacga gcaggcgatt cagaacgcag cgagccatgg agtgcaagcc gtcagcgaga 12060
gctttgcact ggactgcccg cctttgcccg gacacggctg taagtcttgt gaatttcatc 12120
gcatcaatac tggagataaa gctgtgttat gtgcactttg ctatatgaga gcgtacaacc 12180
attgtgttta cagtaagtgt gattaagtga actttaaagg gaggcaaaga gtagggtgac 12240
tgggtgatga ctggtttatt tatgtatatc tgttttttat ataggtcccg tttctgacgc 12300
agatgatgag acccccacta cagagtccac tttgtcaccc cctgaaattg gcacgtctcc 12360
atctgacaat attgttagac cagttcctgt aagagccact gggaggagag cagctgtaga 12420
atgtttggat gatttgcttc agggtggaga tgaacctttg gacttgtgta cccggaaacg 12480
ccccaggcat taagtgccac acatgtgtgt ttacttgagg tgatgtcagt atttataggg 12540
tgtggagtgc aataaaatat gtgttgactt taagtgcgtg gtttatgact caggggaggg 12600
gactttgggt atataagcag gtgcagacct gtgtggttag ctcagagcgg tatggagatt 12660
tggacggttt tggaagactt tcacaagact aggcagctgc tagagaacgc ctcgaacgga 12720
gtctcttacc tgtggagatt ctgcttcggc ggtgacctag ctaagctagt ctatagggcc 12780
aaacaggatt atagggaaca atttgaggat attttgagag agtgtcctgg tctttttgac 12840
gctcttaact tgggccatca gtctcacttt aaccagagaa tttcaagagc ccttgacttt 12900
actactcctg gcagaaccac tgcagcagta gccttttttg cttttatttt tgacaaatgg 12960
agtcaagaaa cccatttcag cagggattac cagctggatt tcttagcagt agctttgtgg 13020
agaacatgga agtgccagcg cctgaatgca atctccggct acttgccggt acagccgcta 13080
gacactctga ggatcctgag tctccagcag caggaggatc aagaagagaa tccgagagcc 13140
ggcctggacc ctccggcgga ggagtagctg acctgtttcc tgaactgcac cgggtgctga 13200
ctaggtcttc gagtggtcgg gagaggggta ttaagcggga gaggcatgat gagactaatc 13260
acagaattga actgactgtg ggtctgatga gccgcaagcg tccagaaaca gtgtggtggt 13320
atgaggtgca gtcaactggc acagatgagg tgtcagtcat gcatgagaga ttttccctag 13380
aacaagtcaa gacttgttgg ttggagcctg aggatgattg ggaggtagcc atcaggaatt 13440
atgccaagct ggctctgagg ccagatagaa agtacaagat tactaagctg ataaatatca 13500
gaaatgcctg ctacatctca gggaatgggg ctgaagtgga gatctgtctc caggatagag 13560
tggctttcag atgctgcatg atgaatatgt acccgggagt ggtggacatg gatggggtca 13620
cctttatgaa catgaggttc aggggagatg ggtataatgg gacggtcttt atggccaata 13680
ccaagctgac agtgcatgga tgctccttct ttgggtttaa taacacctgc atcgaggctt 13740
ggggtcaggt cggtgttaag gggtgcagtt tttcagccaa ctggatgggg gtagtgggca 13800
ggaccaagag tatgctgtct gtgaagaaat gcttgtttga gaggtgccac ctgggggtga 13860
tgagcgaggg cgaagccaga atccgccact gtgcctctac cgagacgggc tgttttgtgc 13920
tgtgcaaggg caatgccaag atcaagcata atatgatctg tggagcctcg gacgagcgcg 13980
gctaccagat gctgacctgc gccggtggga acagtcatat gctggccgcc gtgcatgtgg 14040
cttcccattc ccgcaagccc tggcctgagt tcgagcacaa tgtcatgacc aggtgcaata 14100
tgcatctggg ggctcgccga ggcatgttta tgccctacca gtgcaacctg aattatgtaa 14160
aggtgctcct ggagcccgat gtcatgtcca gagtgagcct gacgggggtg tttgacatga 14220
atgtggaagt gtggaagatt ctaagatatg atgaatacaa gaccaggtgt cgagcctgcg 14280
agtgcggagg gaagcatgcc aggttccagc ccgtgtgtgt ggatgtgacg gaggacctgc 14340
gacccgatca tttggtgttg tcctgcaccg ggacggagtt cggctccagt ggggaagaat 14400
ctgactagag tgagtagtgt tttggggagg gagaggacct gcataagggg cagaatgatt 14460
aaaatctgtg cttttctgtg tgttgcagca gcatgagcgg aaacggctcc tttgagggag 14520
gggtattcag cccttatctg acggggcgtc tcccctcctg ggcgggagtg cgtcaaaatg 14580
tgatgggatc cacggtggac ggccggcccg tacagcccgc gaactcttca accctgacct 14640
atgcaaccct gagctcctcg tcggtggacg cagctgccgc cgcagctgct gcttctgccg 14700
ccagcgccgt gcgcggaatg gccatgggcg ccggctatta cggcactctg gtggccaact 14760
cgagttccac taataatccc gccagcctga acgaggagaa gctgctgctg ttgatggccc 14820
agctcgaggc cttgacccag cgcctgggcg agctgaccca gcaggtggct cagctgcagg 14880
agcagacgcg ggccgcggtt gccacggtga aatccaaata aaaaatgaat caataaataa 14940
acggagacgg ttgttgattt taaaaatcag agtctgaatc tttatttgat ttttcgcgca 15000
cggtaggccc tggaccaccg gcctcgatca ttgagcaccc ggtggatctt ttccaagacc 15060
cggtagaggt gggattggat attgaggtac atgggcatga gcccgtcccg ggggtgaagg 15120
tagctccatt gcagggcctc gtgctcgggg gtggtgttgt aaatcaccca gtcatagcag 15180
ggacgcaggg cgtggtgttg cacaatatct ttgaggagga gactgatggc cacgggcagc 15240
cctttggtgt aggtgtttac aaacctgttg agctgggagg gatgcatgcg gggggagatg 15300
aggtgcatct tagcctggat cttcagattg gcgatgttac cgcccagatc ccgcctggga 15360
ttcatgttgt gcaggaccac cagcacggtg tatccggtgc acttggggaa tttgtcatgc 15420
aacttggaag ggaaggcatg aaagaatttg gagacgccct tgtggccgcc caggttttcc 15480
atgcactcat ccatgataat ggctatgggc ccgtgggcgg cggcttgggc aaagacgttt 15540
cgggggtcgg acacatcgta gttgtggtcc tgggtgagat cttcataggc cattttaatg 15600
aatttggggc ggagggtgcc cgattggggg acgaaggtac cctcaatccc gggggcgtag 15660
tttccctcac agatctgcat ctcccaggcc ttaagctccg agggggggat catgtccacc 15720
tgcggggcga taaagaaaac ggtttccggg gcgggggaga tgagctgggc ggaaagcagg 15780
ttgcggagta gctgggactt accgcagccg gtggggccgt agataacccc aatgaccggc 15840
tgcaggtggt agttgaggga gacacagctg ccgtcctccc taagaagggg ggccacctcg 15900
ttcatcattt ggcgcacgtg catgttctcg cgcaccagtt ccgccaggag tcgctctccg 15960
cccagcgaga ggagctcctg gagcgaggcg aagtttttca gcggcttgag cccgtcggcc 16020
atgggcattt tggaaagggt ctgttgcagg agttccaagc ggtcccagag ctcggtgatg 16080
tgctctacgg catctcgatc cagcagacct cctcgtttcg cgggttgggg cgactgcggg 16140
agtagggcgc cagacgatgg gcgtccagcg cggccagggt ccggtccttc cagggtcgca 16200
gcgtccgcgt cagggtggtc tccgtcacgg taaaggggtg cgcgccgggc tgggcgcttg 16260
cgagggtgcg cttcaggctc atccggctgg tcgagaaccg ctcccgatcg gcgccctgtg 16320
cgtcggccag gtagcaattg accatgagtt cgtagttgag cgcctcggcc gcgtggcctt 16380
tggcgcggag cttacctttg gaagtctgcc cacaggcggg acagaggagg gacttgaggg 16440
cgtagagctt gggggcgagg aagacggact cgggggcgta ggcgtccgcg ccgcagtggg 16500
cgcagacggt ctcgcactcc acgagccagg tgaggtcggg ctgattggga tcaaaaacca 16560
gttttccgcc gttctttttg atgcgtttct tacctctggt ctccatgagc tcgtgtcccc 16620
gctgggtgac aaagaggctg tccgtgtccc cgtaaaccga ctttatgggt cggtcctcga 16680
gtgggacgcc gcggtcctcg tcgtagagga aacccgacca ctctgagacg aaggcccggg 16740
tccaagccag cacgaaggag gccacgtggg agggatagcg gtcgttatcc accagcgggt 16800
ccaccttctc cagtgtatgc aaacacatgt ccccctcgtc cacatccagg aaggtgattg 16860
gcttgtaagt gtaggccacg tgaccggggg tcccggccgg gggggtataa aagggggcgg 16920
gccgctgctc gtcttcactg tcttccggat cgctgtccag gagcgccagc tgttggggta 16980
ggtattccct ctcaaaggcg ggcatgacct ccgcactcag gttgtcagtt tctagaaacg 17040
aggaggattt gatattgacg gtgccggcgg agatgccttt caagagcccc tcgtccatct 17100
ggtcagaaaa gacaatcttt ttgttgtcga gtttggtggc gaaggagccg tagagggcgt 17160
tggagaggag cttggcgatg gagcgcatgg tctggttctt ttccttgtcg gcgcgctcct 17220
tggcggcgat gttgagctgc acgtactcgc gcgccacgca cttccattcg gggaagacgg 17280
tggttagctc gtctggcacg attctgacct gccagccccg gttatgcagg gtgatgaggt 17340
caacgctggt ggccacctcg ccgcgcaggg gctcgttggt ccagcagagg cggccgccct 17400
tgcgcgagca gaaggggggc agggggtcca gcataagctc gtcggggggg tcagcatcga 17460
tggtgaagat gcctggcagg aggtcggggt cgaagtagct tatgcaggtg cccagatcgt 17520
ccagagaagc ttgccattcg cgcacggcca gcgcgcgctc gtagggacta aggggcgtgc 17580
cccagggcat ggggtgggtg agcgcggagg cgtacatgcc gcagatgtcg tagacgtaga 17640
ggggctcatc aaggatgcca atgtaggtgg ggtagcagcg gcccccgcgg atgctggcgc 17700
gcacgtagtc atacaactcg tgcgaggggg cgaggagccc ggctccgaga ttggcgcggc 17760
tgggtttttc ggcgcggtag acgatctgac ggaagatggc gtgggagttg gaggagatgg 17820
tgggtctttg gaagatgttg aagtgggcgt ggggcaggcc gaccgagtcg cggatgaagt 17880
gggcgtagga gtcttgcagc ttggcgacaa gctcggcggt gacgaggacg tccagggcgc 17940
agtagtcaag ggtctcttgg atgatgtcat acttgagctg gcccttttgt ttccacagct 18000
cgcggttgag aaggaactct tcgcggtcct tccagtactc ttcaaggggg aacccgtcct 18060
ggtcggcacg gtaagagcct agcatgtaga actggttaac ggccttgtag gcgcagcagc 18120
ccttctccac ggggagggca taggcctggg cggccttgcg cagggaggtg tgcgtgaggg 18180
cgaaggtgtc cctgaccatg acctttagga actggtgctt gaagtcgata tcgtcgcagc 18240
ccccctgctc ccagagctgg aagtccgtgc gcttcttgta ggcggggttg ggcaaagcga 18300
aagtaacatc gttgaagagg atcttgcccg cgcggggcat aaagttgcga gtgatgcgga 18360
aaggctgggg cacctcggcc cggttgttga tgacctgggc ggcgagcacg atctcgtcga 18420
agccgttaat gttgtggccc acaatgtata gttccacgaa ccgcgggcgg cccttgacgt 18480
ggggcagttt cttgagctcc tcgtaggtga gctcgtcggg gtcgctgagc ccgtgctgct 18540
cgagggccca gtcggcgaga tgggggttgg cgcggaggaa ggaagtccag agatccacgg 18600
ccagggcggt ttgcagacga tcccggtact ggcggaactg ctgacccacg gccatttttt 18660
cgggggtgac gcagtagaag gtgcgggggt cgccgtgcca acggtcccat tttagctgga 18720
gggcgagatc aagggcgagc tcaacgagcc ggtcgtcccc ggagagtttc atgaccagca 18780
tgaaggggac gagctgcttg ccgaaggacc ccatccaggt gtaggtttcc acatcgtagg 18840
tgaggaagag cctttcggtg cgaggatgcg agccgatggg gaagaactgg atctcctgcc 18900
accagttgga ggaatggctg ttgatgtgat ggaagtagaa atgccgacgg cgcgccgaac 18960
attcgtgctt gtgtttatac aagcggccac agtgctcgca acgctgcacg ggatgcacgt 19020
gctgcacgag ctgtacctgg gttcctttga cgaggaattt cagtgggaag tggagtcgtg 19080
gcgcctgcat ctggtgctgt actacgtcgt ggtggtcggc ctggccctct tctgcctcga 19140
tggtggtcat gctgacgagc ccgcgcggga ggcaggtcca gacctcggcg cgaacgggtc 19200
ggagagcgag gacgagggcg cgcaggccgg agctgtccag ggtcctgaga cgctgcggag 19260
tcaggtcagt gggcagcggc ggcgcgcggt tgacttgcag gagtttttca agggcgcgcg 19320
ggaggtccag atggtacttg atctccaccg cgccgttggt ggcgacgtcg atggcttgca 19380
gtgtcccgtg cccctgggga gtgaccaccg tcccccgttt cttcttggcg ggcggaagcg 19440
gtttggcttc catggttaaa agcggcggcg aggacgcgcg ccgggcggta ggggcggctc 19500
gggacccgga ggcagtggtg gcaggggcac gtcggcgccg cgcgcgggca ggttctggta 19560
ctgcgcccgg agaagactgg cgtgagcgac gacgcgacgg ttgacgtcct ggatctgacg 19620
cctctgggtg aaggccacgg gacccgtgag tttgaacctg aaagacagtt cgacagaatc 19680
aatctcggta tcattgacgg cggcctgccg cagaatctct tgcacgtcgc ccgagttgtc 19740
ctggtaggca atctcggtca tgaactgctc gatctcctcc tcctgaaggt ctccgcggcc 19800
ggcgcgctcc acggtggccg cgaggtcgtt ggagatgcgg cccatgagct gcgagaaggc 19860
gttcatgccc gcctcgttcc agacgcggct gtaaaccacg gcgccctcgg gatcgcgggc 19920
gcgcatgacc acctgggcga ggttgagctc cacgtggcgc gcaaaaaccg cgtagttgca 19980
gaggcgctgg tagaggtagt tgagcgtggt ggcaatgtgc tcagtgacaa agaagtacat 20040
aatccagcgg cggagcggca tttcgctgac gtcgcccagg gcttccaagc gctccatggc 20100
ctcgtaaaag tccacggcga agttgaaaaa ctgggagttg cgtgcagata cggtcaagtc 20160
ctcctccaga agacggatga gctcggcgat ggtggcgcgc acctcgcgct cgaaggctcc 20220
cgggagttcc tccacttcct cctcttcatc cactaacatc tcttctactt cctcctcagg 20280
cggtggtggc gggggagggg gcctgcgtcg ccggcggcgc acgggcagac ggtcgatgaa 20340
acgctcgatg gtctcgccgc gccggcgtcg catggtctcg gtgacggcgc gcccgtcctc 20400
gcggggtcgc agcgtaaaga cgccgccgcg catctccagg tggcccgggg ggtccccgtt 20460
gggcagggag agtgcgctga cgatgcatct tatcaattgc cccgtaggga ctccgcgcaa 20520
ggacctaagc gtctctagat ccacgggatc tgaaaaccgt tgaacgaagg cttcgagcca 20580
gtcgcagtcg caaggtaggc tgagcacggt ttcttctggc ggcggtgggg tgtgggcggg 20640
ggcgatgctg ctggtgatga agttgaaata ggcggttctg agacggcgga tggtggcgag 20700
gagcaccagg tctttgggcc cggcttgctg gatgcgcaga cggtcggcca tgccccaggc 20760
gtggtcctga cacctggcca ggtccttgta gtagtcctgc atgagccgct ccacgggcac 20820
ctcctcctcg cccgcgcggc cgtgcatacg cgtgagccca aacccgcgct gcggctggac 20880
gagcgccagg tcagcgacga cgcgctcggc gaggatggcc tgctggatct gggtgagggt 20940
ggtctggaag tcgtcaaagt cgacgaagcg gtggtaggct ccggtgttaa tggtgtagga 21000
gcagttggcc atgacggacc agttgacagt ctggtgaccg ggccgcgcga gctcgtggta 21060
cttgaggcgc gagtaggcgc gcgagtcgaa gatgtagtcg ttgcaggtgc gcaccaggta 21120
ctggtagccg atgaggaagt gcggcggcgg ctggcggtag agcggccatc gctcggtggc 21180
gggggcgccg ggcgctaggt cctcgagcat ggtgcggtgg tagccgtaga tgtaccttga 21240
catccaggtg atgccggcgg cggtggtgga ggcgcgaggg aactcgcgga cgcggttcca 21300
gatgttgcgc agcggcagga agtagttcat ggtgggcacg gtctggcccg tgaggcgcgc 21360
gcagtcgttg atgctctaga catacgggca aaaacgaaag cggtcagcgg ctcgactccg 21420
tggcctggag gctaagcgaa cgggttgggc tgcgcgtgta ccccggttcg aatctcgaat 21480
caggctggag ccgcagctaa cgtggtactg gcactcccgt ctcgacccag gcctgcacaa 21540
aacctccagg atacggaggc gggtcgtttt gcaaattttt ggcggtcgaa aaaagctagt 21600
aagcgcggaa agcggccgac cgcaatggct cactgccgta gattggagaa gaatcgccag 21660
ggttgcgttg cggtgtgccc cggttcgaga ccgctcgggt cggccgaatt ccgcggctaa 21720
cgagggcgtg gctgccccgt cgtttccaag accccataag ccagccgact tctccagtta 21780
cggagcgagc ccctcttttg ttttgttttt tgccagatgc atcccgtact gcggcagatg 21840
cgcccccacc ctccaccgca acagcagccc cctcctacgc aacagccggc gcttctgcct 21900
ccgccccagc agcagcaact tccagccact accgccgcgg ccgccgtgag cggggccggg 21960
cagagtcagt atgacctggc tttggaagag ggcgaggggc tggcgcgcct gggggcgtcg 22020
tcgccggagc ggcacccgcg cgtgcagatg aaaagggacg ctcgcgaggc ctacgtgccc 22080
aagcagaacc tgttcagaga caggagcggc gaggagcccg aggagatgcg cgcagcccgt 22140
ttccacgcgg ggcgggagct gcggcgcggc ctggacagaa agagggtgct gagggacgag 22200
gatttcgagg cggacgagct gacggggatc agccctgcgc gcgcgcacgt ggccgcggcc 22260
aacctggtca cggcgtacga gcagaccgtg aaggaggaga gcaacttcca aaaatccttc 22320
aacaaccacg tgcgcaccct gatcgcgcgc gaggaggtga ccctgggcct gatgcacctg 22380
tgggacctgc tggaggccat tgtgcagaac cccaccagca aaccgctgac ggcgcagctg 22440
ttcctggtgg tgcagcacag tcgggacaac gagactttta gggaggcgct gctgaatatc 22500
accgagcccg agggccgctg gcttctggac ctggtgaata ttctgcagag catcgtggtg 22560
caggagcgcg ggctgccgct gtccgagaag ctggcggcca tcaacttttc ggtgctgagt 22620
ttgggcaagt actacgctag gaagatctac aagaccccgt acgtgcccat agacaaggag 22680
gtgaagatcg acgggtttta catgcgcatg accctgaaag tgctgaccct gagcgacgat 22740
ctgggggtgt accgcaacga caggatgcgc cgcgcggtaa gcgccagcag gcggcgcgag 22800
ctgagcgatc aggagctgat gcacagcctg cagcgggccc tgaccggggc cgggaccgag 22860
ggggagagct actttgacat gggcgcggac ctgcactggc agcccagccg ccgggtcttg 22920
gaagccgcgg cggtccctta cgtagaagag gtggacgatg aggatgaggg cgagtacctg 22980
gaagactgat ggcgcgaccg tatttttgct agatgcagca acagccacct cctgatcccg 23040
caatgcgggc ggcgctgcag agccagccgt ccggcattaa ctcctcggac gattggaccc 23100
aggccatgca acgcatcatg gcgctgacga cccgcaaccc cgaagccttt agacagcagc 23160
cccaggccaa ccggctctcg gccatcctgg aggccgtggt gccctcgcgc tccaacccca 23220
cgcacgagaa ggtgctggcc atcgtgaacg cgctggttga gaacaaggcc attcgcggcg 23280
acgaggccgg gctggtgtac aacgcactgc tggagcgcgt ggcccgctac aacagcacca 23340
acgtgcagac caacctggac cgcatggtga ccgacgtgcg cgaagccgtg gcccagcgcg 23400
aacggttcca ccgcgagtcc aacctgggat ccatggtggc actgaacgcc ttcctcagca 23460
cgcagcccgc caacgtgccc cggggccagg aggactacac caacttcatt agcgccctgc 23520
ggctaatggt gaccgaggtg ccccagagcg aggtgtacca gtcgggcccg gactacttct 23580
tccagaccag tcgccagggc ttgcagaccg tgaacctgag tcaggctttc aagaacttgc 23640
agggactgtg gggcgtgcag gctccggtcg gggaccgcgc gacggtgtcg agcctgctga 23700
cgccgaactc gcgcctgctg ctgctgctgg tggcgccctt cacggacagc ggtagtatca 23760
accgcaactc gtacctgggc tacctgatta acctgtaccg cgaggccatt ggccaggcgc 23820
acgtggacga gcagacctac caggagatta cccacgtgag ccgcgccctc ggccaggacg 23880
acccgggcaa tctggaagcc accctgaact tcttgctgac caaccggtcg cagaagatcc 23940
cgccccagta cgcgctgagc gccgaggagg agcgtatatt gagatacgtg cagcaaagtg 24000
tgggactgtt cctgatgcag gagggggcca cccccagcgc cgcgctcgac atgaccgcgc 24060
gcaacatgga gcccagcatg tacgccagta atcgcccgtt tattaataag ctgatggact 24120
acctgcatcg ggcggccgcc atgaactctg actatttcac caacgccatc ctgaaccccc 24180
actggctccc gccgccgggg ttctacacgg gcgagtacga catgcccgac cccaatgacg 24240
ggtttctgtg ggacgacgtg gacagcagcg tgttctcccc ccgaccgggt gctaacgagc 24300
gccccttgtg gaagaaagag ggcagcgacc ggcgcccgtc ctcggcgctg tccggccgca 24360
cgggtgctgc cgcagcggtg cccgaggccg ccagtccctt tccgagcttg tcactgaaca 24420
gcgtccgcag tagcgagctg ggcaggatca cgcgcccgcg cttgctgggc gaggaggagt 24480
acttaaataa ctcgctgttg aggcccgagc gggagaagaa cttccccaat aacgggatag 24540
agagtctggt ggataagatg agccgctgga agacgtacgc gcatgagcac agggacgatc 24600
cccgggcaac gcagggggcc accagccggg gcagtgccgc ccgtaaacgc cgctggcacg 24660
acaggcagcg gggactgatg tgggacgatg aggattccgc cgacgacagc agcgtgttgg 24720
acttgggcgg gagtggtggt ggtaacccgt tcgctcacct gcgcccccgc gtcgggcgcc 24780
tgatgtaaaa agaaaccaaa aataaatggt actcaccaag gccatggcga ccagcgtgcg 24840
ttcgtttctt ctctgttgta tctagtatga tgaggcgtgc gtacccggag ggtcctcctc 24900
cctcgtacga gagcgtgatg cagcaggcaa tggcggcggc ggcggcgatg cagcccccgc 24960
tggaggctcc ttacgtgcca ccgcggtacc tggcgcctac ggaggggcga aacagcattc 25020
gttactcgga gctggcaccc ttgtacgata ccacccggtt gtacctggtg gacaacaagt 25080
cggcggacat cgcctcgctg aactaccaga acgaccacag caactttctg accaccgtgg 25140
tgcagaacaa cgatttcacc cccacggagg ccagcaccca gaccatcaac tttgacgagc 25200
gctcgcggtg gggcggtcag ctgaaaacca tcatgcatac caacatgccc aacgtgaacg 25260
agttcatgta cagcaacaag ttcaaggcgc gggtcatggt ctcccgcaag acccccaacg 25320
gggtgacagt aggggatgat tatgatggta gtcaggatga gctgaaatac gagtgggtgg 25380
agtttgagct gcccgaaggc aacttctcgg tgaccatgac cattgacctg atgaacaacg 25440
ccatcatcga caattacttg gcagtggggc ggcagaacgg ggtgctggag agcgacatcg 25500
gcgtgaagtt cgacacccgg aacttcaggc tgggttggga ccccgtgacc gagctggtca 25560
tgcccggggt gtacaccaac gaggccttcc accccgacat cgtgctgttg cccggctgcg 25620
gggtggactt taccgagagc cgcctcagta atatgctggg catccgcaag aggcagccct 25680
tccaggaggg tttccagatc atgtacgagg acctggatgg aggtaacatc cccgcgctct 25740
tggatgtcga ggcctatgag aaaagcaagg aggagagcgt cgccgcgtca accgcagccg 25800
tagccaccgc ctctaccgag gtccggggcg ataattttgc tagcgccgca gcagtggcgg 25860
cggccaaggc tgatgaaacc gaaagtaaga tagttattca gccggtggag aaggatagca 25920
aggataggag ctacaacgtg ctctcggaca agaaaaacac cgcctaccgc agctggtacc 25980
tggcctacaa ctatggcgac cacgagaagg gcgtgcgctc ctggacgctg ctcaccacct 26040
cggacgtcac ctgcggcgtg gagcaagtct actggtcgct gcccgacatg atgcaagacc 26100
cggtcacctt ccgctccacg cgtcaagtta gcaactaccc ggtggtgggc gccgagctca 26160
tgcccgtcta ctccaagagc ttcttcaacg agcaggccgt ctactcgcag cagctgcgcg 26220
ccttcacctc gctcacgcac gtcttcaacc gcttccctga gaaccagatc ctcgtccgcc 26280
cgcccgcgcc caccattacc accgtcagtg aaaacgttcc tgctctcaca gatcacggga 26340
ccctgccgct gcgcagcagt atccggggag tccagcgcgt gaccgttact gacgccagac 26400
gccgcacctg cccctacgtc tacaaggccc tgggcatagt cgcgccgcgc gtcctctcga 26460
gccgcacctt ctaaaaaatg tccattctca tctcgcccag taataacacc ggttggggtc 26520
tgcgcgcgcc cagcaagatg tacggaggcg ctcgccaacg ctccacgcaa caccccgtgc 26580
gcgtgcgcgg gcacttccgc gctccctggg gcgccctcaa gggccgcgtg cggtcgcgca 26640
ccaccgtcga cgacgtgatc gaccaggtgg tggccgacgc tcgcaactac acccccgccg 26700
ccgcgcccgt ctccaccgtg gacgccgtca ttgacagcgt ggtgtccgac gcgcgccggt 26760
acgcccgcgc caagagccgg cggcggcgca tcgcccggcg gcaccgtagc accaccgcca 26820
tgcgtgcggc gcgagccttg ctgcgcaggg ccaggcgcac gggacgcagg gccatgctca 26880
gggcggccag acgcgcggct tcaggcgcca gcgccggcag gactcggaga cgcgcggcca 26940
cggcggcggc agcggccata gccagcatgt cccgcccgcg gcgagggaac gtgtactggg 27000
tgcgcgacgc cgccaccggt gtgcgcgtgc ccgtgcgcac ccgcccccct cgcacttgaa 27060
gatgttcact tcgcgatgtt gatgtgtccc agcggcgagg agaaggatgt ccaagcgcaa 27120
attcaaggaa gagatgctcc aggtcatcgc gcctgagatc tacggccccg cggcggcggt 27180
gaaggatgaa agaaatcccc gcaaaatcaa gcgggtcaaa aaggacaaaa aggaagaaga 27240
tgatgtggac gatatggtag agtttgtgcg cgagtttgcc ccccggaggc gcgtgcagtg 27300
gcgcgggcgg aaagtgcgtc cggtgctgag acccggcacc acggtggttt tcgcgcctgg 27360
cgagcggtcc ggcacgacat ccaagcgctc ctacgatgag gtgtacgggg acgaggatat 27420
tctcgagcag gcggccgagc gcctgggcga gtttgcttac ggcaagcgca accgccttgc 27480
gcccctgaag gaagaggtgg tgtccatccc gctggaccac ggcaacccca cgccgagtct 27540
taagcccgtg accctgcagc aggtgctgcc gagcgcggcg ccgcgtcggg gcttgaagcg 27600
cgagggcgag gatgtgtacc ccaccatgca gctgatggtg cccaagcgcc agaagctgga 27660
agacgtgctg gagaccatga aggtggaccc ggacgtgcag cccgaggtca aggtgaggcc 27720
catcaagcag gtggccccgg gccttggcgt gcagaccgtg gacatcaaga tccccacgga 27780
gcccatggaa acgcagaccg aggtcgtgaa gcccatcacc agcaccatgg aggtgcagac 27840
ggatccttgg atgccggcgg cgccccgaaa accccggcgc aagtacggcg cggccagcct 27900
gctgatgccc aactacgcgc tgcatccttc catcatcccc acgccgggct accgcggcac 27960
gcgcttctac cacggctata ccggctcccg ccgccgcaag accaccaccc gccgccgtcg 28020
tcgccgcaca gctgcaactc ccgctgccgc cctggtgcgg agagtgtacc gccgcggccg 28080
cgcgcctctg accctgccgc gggcgcgcta ccacccgagc attaccattt aactttgccg 28140
tcgcctttgc agatatggct ctcacatgcc gcattcgcgt ccccattacg ggctaccgag 28200
gaagaaaacc gcgccgtaga aggctggcgg gaagcgggat gcgccgccac ccccaccggc 28260
ggcggcgcgc catcagcaag cggttggggg gaggcttcct gcccgcgctg atccccatca 28320
tcgccgcggc gatcggggcg atccccggca ttgcttccgt ggcggtgcag gcctctcagc 28380
gccactgaga cacacacttg gaaattgtaa taaacccgaa tggactctga cgctcctggt 28440
cctgtgatgt gtttttgtag acagatggaa gacatcaatt tttcgtccct ggctccgcga 28500
cacggcacgc ggccgtttat gggcacctgg agcgacatcg gcaccagcca actgaacggg 28560
ggcgccttca attggagcag tctctggagc gggcttaaga attttgggtc cacgcttaaa 28620
acctatggca gcaaggcgtg gaacagcacc acagggcagg cgctgagaga taagctgaaa 28680
gagcagaact tccagcagaa ggtagtcgat ggcctcgcct caggcatcaa cggggtggtg 28740
gacctggcca atcaggccgt gcagcggcag atcaacagcc gcctggaccc ggttcccccc 28800
gccggctccg tggagatgcc gcaggtggag gaggagctgc ctcccctgga caagcggggc 28860
gacaagcgtc cccgtcccga cgcggaggag acgctgctga cgcacacgga cgaaccgccc 28920
ccgtacgagg aggcggtgaa actgggcctg cccaccacgc gtcccattgc gcctctagct 28980
accggggtgc tgaaacccga gagtagtaag cccgcgacct tggacttgcc tcctccgccc 29040
actccccgcc cctccacagt ggctaagccc ctgccgccgg tggccgtggc ccgcgcgcga 29100
ccgggggctc gccctcaggc gaactggcag agcactctga acagcatcgt gggtctggga 29160
gtgcagagtg tgaagcgccg ccgctgttat taaaaaacac tgtagcgctt aacttgcttg 29220
tctgtgtata tgtgtatgtc cgccgccgct gctgtccaga aggaggagtg aagagaaagg 29280
cgcgtcgtcg agttgcaaga tggccacccc atcgatgctg ccccagtggg cgtacatgca 29340
catcgccgga caggacgctt cggagtacct gagtccgggt ctggtgcagt tcgcccgcgc 29400
cacagacacc tacttcagtc tggggaacaa gtttaggaac cccacggtgg cgcctaccca 29460
cgatgtgacc accgaccgca gccagcggct gacgctgcgc tttgtgcccg tggaccggga 29520
ggacaacacc tactcgtaca aagtgcgcta cacgctggcc gtgggcgaca accgcgtgct 29580
ggacatggcc agcacctact ttgacatccg cggcgtgctg gatcggggcc ctagcttcaa 29640
accctactcc ggcactgcct acaacagcct ggctcccaag ggagcgccca acacctgcca 29700
gtggaaggat tctgacagca aaatgcatac ctttggggca gctgccatgc ccggtgttac 29760
tgggaaaaag atagaagctg atgggctgcc tattagaata gattcaactt ctggaactga 29820
cacagtaatt tatgctgata aaactttcca accagaacca caagttggaa atgacagttg 29880
ggttgacacc aatggtgcag aggaaaaata tggaggcaga gctctaaagg acactacaaa 29940
aatgaaaccc tgttatggtt cattcgccaa gcctaccaac aaagaaggtg gtcaggctaa 30000
cttaaaagat tcagaacccg ccgccaccac tcctaactat gatatagacc tggctttctt 30060
tgacagcaaa actattgttg ctaactacga tccagatatt gtaatgtaca cagaaaatgt 30120
tgacttgcag actccagata ctcatattgt atacaaacct ggaacagagg acaccagctc 30180
tgaatccaat ttgggtcagc aggccatgcc taacagaccc aactacattg gcttcagaga 30240
caattttatc gggctcatgt actacaacag cactggcaat atgggggtgc tggccggtca 30300
ggcctctcag ctgaatgctg tggttgactt gcaagacaga aacactgaac tgtcctacca 30360
gctcttgctt gactctctgg gtgacagaac ccggtatttc agtatgtgga atcaggcggt 30420
ggacagctat gatcctgatg tgcgcattat tgaaaaccat ggtgtggagg atgaattgcc 30480
aaactattgc tttccgttga atggtgtggg attgacagac acttaccagg gtgttaaagt 30540
taaaacagat gcaggttctg aaaagtggga caaagatgac accacagtta gtaatgctaa 30600
tgaaatccat gtaggcaatc cttttgccat ggaaatcaac atccaagcca acctgtggag 30660
gaacttcctc tatgccaatg ttgccctcta tttgcctgat aaatacaaat acacaccggc 30720
caacatcacc ctgcccacca acaccaacac ctacgagtac atgaacggcc gggtggtggc 30780
gccctcgctg gtggacgcct acattaacat tggggcgcgc tggtcgctgg accccatgga 30840
caacgtaaat cccttcaacc accaccgcaa tgcgggcttg cgctaccgct ccatgctcct 30900
gggcaacggg cgctacgtgc cattccacat ccwggtgccc cagaaatttt ttgccattaa 30960
gagcctcctg ctcctgcccg ggtcctacac ctacgagtgg aacttccgca aggacgtcaa 31020
catgatcctg cagagttccc ttggcaacga cctgcgcaca gacggggcct ccatcacctt 31080
caccagcatt aacctctacg ccaccttctt ccccatggcg cacaacaccg cctccacgct 31140
tgaggccatg ctgcgcaacg acaccaatga ccaatccttc aacgactacc tctcggcggc 31200
caacatgctc tatcccatcc cggccaacgc caccaacgtg cccatctcca tcccctcgcg 31260
caactgggcc gcctttcgcg gctggtcctt cacgcgactc aagaccaaag agacgccctc 31320
gctgggctcc gggttcgacc cctacttcgt ctactcgggc tccatcccct acctcgacgg 31380
caccttctac ctcaaccaca ccttcaagaa ggtctccatc accttcgact cttccgtcag 31440
ctggcccggc aacgaccggc tcctgacgcc caacgagttc gaaatcaagc gcaccgtcga 31500
cggcgaggga tacaacgtgg cccagtgcaa catgaccaag gactggttcc tggtccagat 31560
gctggcccac tacaacatcg gctaccaggg cttctacgtg cccgagggct acaaggaccg 31620
catgtactcc ttcttccgca acttccagcc catgagccgc caggtggtgg acgaggttaa 31680
ctacaaggac taccaggccg tcaccctggc ctaccaacac aacaactcgg gcttcgttgg 31740
atacctcgcg cccactatgc gccagggcca gccctacccc gccaactacc cctacccgct 31800
catcggcaag agcgccgtta ccagcgtcac ccagaaaaag ttcatctgcg acagggtcat 31860
gtggcgcatc cccttctcca gcaacttcat gtccatgggc gcgctcaccg acctcggcca 31920
gaacatgctc tatgctaact ccgcccacgc gctagacatg aatttcgaag tcgaccccat 31980
ggatgagtcc acccttctct atgttgtctt cgaagtcttc gacgtcgtcc gagtgcacca 32040
gccccaccgc ggcgtcattg aggccgtcta cctgcgcacc cccttctcag ccggtaacgc 32100
caccacataa attcttgctt cttgcaagaa gccatggccg cgggctccgg cgagcaggag 32160
ctcagggcca tcatccgcga cctggggtgc gggccctact tcctgggcac cttcgataag 32220
cgattcccgg gattcatggc cccgcacaag gtggcctgcg ccatcgtcaa cacggccggc 32280
cgcgagaccg ggggcgagca ttggctggcc ttcgcctgga acccgcgctc gaacacctgc 32340
tacctcttcg accccttcgg gttctcggac cagcgcctca agcaaatcta ccagttcgag 32400
tacgagggac tgctgcgccg cagcgccctg gccaccaagg accgctgcgt taccctggaa 32460
aagtccaccc agaccgtgca gggtccgcgt tcggccgcct gcgggctttt ctgctgcatg 32520
ttcctacacg ccttcgtgca ctggcccaac cgccccatgg acaaaaatcc caccatgaac 32580
ttgctgacgg gggtgcccaa cggcatgctc cagtcgcccc aggtggaacc taccctgcgc 32640
cgcaaccagg aggcactcta ccgcttcctc aactcccact ctgcatactt tcgctctcac 32700
cgcgcgcgca ttgagaaggc caccgccttc gaccgcatga atcaagacat gtaacagtgt 32760
gttttaaaat atgtttaata aacagcactt tttatgtgac acatgcattt gagataattt 32820
tattcttaaa aatcgaaggg gttctgccgg gaggtttcgg catggcccgc gggcagggac 32880
acgttgcgga actggtactt ggccagccac ttgaactcgg ggatcagcag tttcggcagc 32940
agggtgtcgg ggaacgagtc ggtccacagc ttccgcgtca gttgcagggc gcccagcagg 33000
tcgggcgcgg agatcttgaa atcgcagttg ggacccgcgt tttgcgcgcg agagttgcgg 33060
tacacagggt tgcagcactg gaacaccatc agggccggat gcttcacgct cgccagcacc 33120
gtagcgtcgg tgatcccgtc cacgtcgagg tcttcggcgt tggccatccc gaagggggtc 33180
atcttgcagg tctgccggcc catggtgggc acgcagccgg gcttgtggtt gcaatcgcag 33240
tgcaggggga tcagcatcat ctgggcctgg tcggcgttca tccccgggta catggccttc 33300
atgaaagcct ccagctgctt aaacgcctgc tgggccttgg ctccctcggt gaagaagacc 33360
ccgcaggact tgctagaaaa ctggttggta gcgcacccgg cgtcgtgcac gcagcagcgc 33420
gcgtcgttgt tggccagctg caccacgctg cgcccccagc ggttctgggt aatcttggcc 33480
cggtcggggt tctcctttag cgcgcgttgc ccgttctcgc ttgccacatc catctcgatc 33540
atgtgctcct tctggatcat ggtggtcccg tgcaggcacc gcagcttgcc ctcgacttcg 33600
gtacagccgt gcagccacag cgcgcacccc gtgctctccc agttcttgtg ggcgatctgg 33660
gaatgcgcat gcacgaaccc ctgcaggaag cggcccatca tggtcgtcag ggtcttgtta 33720
ctggtaaagg tcagcggaat gccgcggtgc tcctcgttga tgtacaggtg gcagatgcgg 33780
cgatacacct cgccctgctc gggcatcagt tggaagttgg attttaggtc gctttccaca 33840
cggtagcgct ccatcagcat attcatgatt tccatgccct tctcccaggc cgatacaatg 33900
ggcaggctca gggggttcgt caccgccatc ttagcgctag cagccttcgt cagcgggtcg 33960
ttctcattga gagtctcaaa gctccgcttg ccgtccttct cggtgatccg cacggggggg 34020
tagctgaagc ccacggccgc cagctcctcc tcggcctctc tttcgtcctc gctgtcctgg 34080
ctgacgtcct gcaggggcac atgcttcgtt ttgcggggtt tctttttggg cggctgctgc 34140
ggcggcggtg gttgttcctg aggcgagggg gagcgcgagt tctcgctcac cactactatc 34200
tcttcttctt ggtccgaggc cacgcggcgg taggtatgtc tcttcagggg cagaggcgga 34260
ggcgacgggc tctcgcggcc cggcgggtgg ctggcagagc cccttccgcg atcgggggtg 34320
cgctcccggc ggcgctctaa ctgacttcct ccgcggccgg ccattgtgtt ctcctaggga 34380
acaacaacaa gcatggagac tcagccatcg tcgccaacct cgccatctgc ccccaccgcc 34440
gacaagaagc agcagcagaa tgagagctta accgccccgc cgcccagccc cgccaccttt 34500
gtcgcggccc cagacatgca agagatggag gaatccattc agattgacct gggctatgtg 34560
acgcccgcgg agcacgagga ggagcttgca gtgcgctttt caacccagga agagatacac 34620
caagaacagc cagagcagga agcaaagagc gagcatgact acctccacca gagcgggggg 34680
gaggacgccc tcatcaagca tctggcccgg caggccatca tcgtcaagga cgcgctgctt 34740
gaccgcaccg aggtgcccct cagcgtggag gagctcagcc gcgcctacga gctcaacctc 34800
ttctcgccgc gcgtgccccc caagcgccag cccaacggca cctgcgagcc caacccacgc 34860
ctcaacttct acccggtctt cgcggtgccc gaggccctgg ccacctacca catctttttc 34920
aagaaccaaa ggatccctgt ctcctgtcgc gccaaccgca cccgcgccga ctcccttttc 34980
aacctgggcc ccggtgcccg cctacctgat atcgcctcct tggaagaggt tcccaagatc 35040
ttcgagggtc tgggcagcga cgagactcgg gccgcaaacg ctctgcaagg agaaggagga 35100
gatcatgagc accacagcgc cctggtggag ttggaaggcg acaacgcgcg tctggcggtg 35160
ctcaagcgca cgatcgagct gacccatttc gcctacccgg cgcttaacct gccccccaaa 35220
gtcatgagca cggttatgga ccaggtgctc atcaagcgcg cgtcgcccat ctccaaggag 35280
atgcaagacc ccgagagctc cgaggagggc aagcccgtgg tcagcgacga gcagctggcg 35340
cggtggctgg gaccccaagc tagtccccag agcttggaag agcggcgcaa gctcataatg 35400
gccgtggtcc tggtgaccgc ggagctggag tgtctgcgcc gcttcttcgc cgacgcagaa 35460
actctgcgca aggtcgagga gaacctgcac tacatcttca ggcacgggtt cgtacgccag 35520
gcctgcaaga tctccaacgt ggagctgacc aacctggtct cctacatggg catcttgcac 35580
gagaaccgcc tggggcagaa cgtgctgcac accaccctgc gcggggaggc ccgccgcgac 35640
tacatccgcg actgcgttta cctctacctc tgccacacct ggcagacagc catgggcgtg 35700
tggcagcagt gtctggagga gcagaaccta aaagagctct gcaagctcct gcagaagaac 35760
ctcaaggccc tgtggaccgg gttcgacgag cgcaccaccg cctcggacct ggcagacctc 35820
attttccccg agcgtctcag gctgacgctg cgcaacggtt tgcccgactt tatgagtcaa 35880
agcatgttgc aaaactttcg ctctttcatc ctcgaacgct ccgggatcct gccggccacc 35940
tgctccgcgc tgccctcgga cttcgtgccg ctgaccttcc gcgagtgccc cccgccgctg 36000
tggagccact gctacctgct gcgcttggcc aactacctgg cctaccactc ggacgtgatc 36060
gaggacgtca gcagcgaggg cctgctcgag tgccactgcc gctgcaacct ctgcacgccg 36120
caccgctccc tggcctgcaa cccccagctg ctgagcgaga cccagatcat cggcaccttc 36180
gagttgcaag ggcccggcga tgagggttct gccgccaagg ggggtctgaa actcaccccg 36240
gggctgtgga cctcggccta cttgcgcaag ttcgtgcccg aggactacca tcccttcgag 36300
atcaggttct acgaggacca atcccagccg cccaaggccg agctgtcggc ctgcgtcatc 36360
acccaggggg cgatcctggc ccaattgcaa gctatccaga aatcccgcca agaattcttg 36420
ctgaaaaagg gccgcggggt ctaccttgat ccccagaccg gtgaggagct taaccccggc 36480
ttcccccagg atgccccgag gaagcagcaa gaagctgaaa gtggagctgc cgcccgtgga 36540
ggatttggag gaagactggg agagcagtca ggcagaggag gaggagatgg aagactggga 36600
cagcactcag gcagaggaca gcctgcaaga cagtctggaa gacgaggagg aggcagagga 36660
ggtggaagaa gtagccgccg ccgccagacc gtcgtcctcg gcggagaaag caagcagcac 36720
ggataccatc tccgctccgg gtcggggtcc cgctcgaccc cacagtagat gggacgagac 36780
cgggcgattc ccgaacccca ccacccagac cggtaagaag gagcggcagg gatacaagtc 36840
ctggcggggg cacaaaaacg ccatcgtctc ctgcttgcaa gcttgcgggg gcaacatctc 36900
attcacccgg cgctacctgc tctttcaccg cggggtgaac ttcccccgca acatcttgca 36960
ttactaccgt cacctccaca gcccctacta cttccaagaa gaggcagaaa aagacaaaac 37020
cagcagctag aaaatccaca gcggcggcgg caggtggact gaggatcgcg gcgaacgagc 37080
cggcgcagac ccgggaactg aggaaccgga tctttcccac cctctatgcc atcttccagc 37140
agagtcgggg gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc tcgctcaccc 37200
gcagttgtct gtatcacaag agcgaagacc aacttcagcg cacgcttgag gacgccgagg 37260
ctctcttcaa caagtactgc gcactcactc ttaaagagta gcccgcgccc gcccacacac 37320
ggaaaaaggc gggaattacg tcacctgtgc acccccaccc agcaccgcta tgagcaaaga 37380
aattcccacg ccttacatgt ggagctacca gccccagatg ggcctggccg ccggcgccgc 37440
ccaggactac tccacccgca tgaattggct cagcgccggg cccgggatga tctcacgggt 37500
gaatgacatc cgcgcccacc gaaaccagat actcctagaa cagtcagcgc tcaccgccac 37560
gccccgcaat cacctcaatc cgcgtaattg gcccgccgcc ctagtgtacc aggaaattcc 37620
ccagcccacg accgtactac ttccgcgaga cgcccaggcc gaagtccagc tgactaactc 37680
aggtgtccag ctggcgggcg gcgccaccct gtgtcgtcac caccccgctc agggtataaa 37740
gcggctggtg atccggggca gaggcacaca gctcaacgac gaggtggtga gctcttcact 37800
gggtttgcga cctgacggag tcttccaact cgccggatcg ggaagatctt ccttcacgcc 37860
tcgtcaggcc gtgctgactt tggagagttc ttcctcgcaa cctcgctcgg gcggcatcgg 37920
cactctccag tttgtggagg agttcactcc ctcggtctac ttcaacccct tctccggctc 37980
ccccggccac tatccggacg agttcatccc gaacttcgat gccatcagcg aatcggtaga 38040
cggctacgat tga 38053
<210> 58
<211> 12
<212> DNA
<213> 人工序列
<220>
<223> 间隔子序列
<400> 58
caaattcctt gg 12
<210> 59
<211> 19
<212> DNA
<213> 人工序列
<220>
<223> Int5靶向序列
<400> 59
tatattatta gatagcctc 19
<210> 60
<211> 20
<212> DNA
<213> 人工序列
<220>
<223> Int4靶向序列
<400> 60
tatattatat agatagcctc 20
<210> 61
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图5A的上序列
<400> 61
aaataaggta tattattgat gatgcctccg gggtccactg caattaataa cttcgtat 58
<210> 62
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图5A的下序列
<400> 62
ttattgatga tgccaaggaa tttgcctccg gggtccactg caattaataa cttcgtat 58
<210> 63
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图5C的上序列
<400> 63
aaataaggta tattattgat gatgcctccg gggtccactg caattaataa cttcgtat 58
<210> 64
<211> 58
<212> DNA
<213> 人工序列
<220>
<223> 图5C的下序列
<400> 64
aaataaggta tattatatag atagcctccg gggtccactg caattaataa cttcgtat 58

Claims (15)

1.一种用于拯救重组腺病毒的环状DNA分子，包含重组腺病毒基因组，所述重组腺病毒基因组在基因组末端侧翼有两个反向末端重复序列(ITR)，其中
至少一个ITR与相邻于PAM序列的靶序列相关联，其中
靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。
2.根据前述权利要求所述的环状DNA分子，其中两个ITR中的每一个与相邻于PAM序列的靶序列相关联。
3.根据前述权利要求所述的环状DNA分子，其中与两个ITR相关联的靶序列是相同的或不同的。
4.根据权利要求1或2所述的环状DNA分子，其中靶序列或PAM定位成相邻于ITR的外末端。
5.根据前述权利要求所述的环状DNA分子，其中与两个ITR相关联的靶序列是相同的。
6.根据权利要求1至3所述的环状DNA分子，其中PAM和/或靶序列与ITR的外末端至少部分重叠，其中优选地，靶序列配置为用于在相应ITR的外末端产生RNA引导的DNA核酸内切酶介导的DNA双链断裂。
7.根据前述权利要求中任一项所述的环状DNA分子，其中环状DNA分子是细菌人工染色体。
8.根据权利要求1-6中任一项所述的环状DNA分子，其中环状DNA分子为高拷贝质粒。
9.根据前述权利要求中任一项所述的环状DNA分子，还包含用于至少一种向导RNA(gRNA)的表达盒和/或用于产生DNA双链断裂的RNA引导的DNA核酸内切酶的表达盒，例如化脓性链球菌Cas9(SpCas9)，其中表达盒位于腺病毒基因组外部的两个ITR之间。
10.根据前述权利要求中任一项所述的环状DNA分子，其中所述腺病毒基因组是人腺病毒载体基因组。
11.根据权利要求1至9所述的环状DNA分子，其中所述腺病毒基因组为猿猴腺病毒载体基因组。
12.根据前述权利要求中任一项所述的环状DNA分子，其中所述腺病毒基因组是腺病毒载体基因组，例如第一代腺病毒载体基因组，优选包含至少一个转基因。
13.一种用于拯救重组腺病毒的试剂盒，包括
a.根据前述权利要求中任一项所述的环状DNA分子，
和
b.RNA引导的DNA核酸内切酶或编码RNA引导的DNA核酸内切酶的核酸分子，
c.一种或多种gRNA或编码一种或多种gRNA的一种或多种核酸分子，用于将RNA引导的DNA核酸内切酶靶向环状DNA分子的靶序列，
和/或
d.适用于拯救重组腺病毒的细胞，例如293细胞或A549细胞。
14.根据前述权利要求所述的试剂盒，其中所述试剂盒包含适用于拯救重组腺病毒的细胞，其中所述细胞表达RNA引导的DNA核酸内切酶，优选SpCas9。
15.一种用于体外拯救重组腺病毒的方法，所述方法包括
a.提供适合拯救重组腺病毒的细胞，例如293细胞，
b.向所述细胞中引入根据权利要求1-12中任一项所述的环状DNA分子，其包含重组腺病毒基因组，所述重组腺病毒基因组在基因组末端侧翼有两个反向末端重复序列(ITR)，其中，至少一个ITR与相邻于PAM序列的靶序列相关联，其中每个靶序列配置为用于在相应ITR的外末端或紧邻外末端外部产生RNA引导的DNA核酸内切酶介导的DNA双链断裂，
c.在细胞内提供RNA引导的DNA核酸内切酶和至少一种gRNA，所述gRNA用于将RNA引导的DNA核酸内切酶靶向环状DNA分子的靶序列，
d.将细胞内包含两个ITR的重组腺病毒基因组线性化，
e.从细胞上清液中收集病毒颗粒。
CN202180067002.0A 2020-09-29 2021-09-29 通过crispr/cas介导的体内末端解析拯救重组腺病毒 Pending CN116323955A (zh)

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US20020136708A1 (en) 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
WO2001021824A1 (en) * 1999-09-23 2001-03-29 Genzyme Corporation Helper vectors and cell lines for the production of pseudoadenoviral vectors
CN111527200A (zh) 2017-12-06 2020-08-11 世代生物公司 使用修饰的封闭端DNA(ceDNA)的基因编辑

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CN116875621A (zh) * 2023-07-18 2023-10-13 浙江大学 一种提高转移载体中ires序列介导筛选基因表达效率的方法
CN116875621B (zh) * 2023-07-18 2024-03-29 浙江大学 一种提高转移载体中ires序列介导筛选基因表达效率的方法

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