KR20210144861A - 아마이엘로이스로부터의 트랜스포사제를 이용한 핵산 작제물의 진핵세포 게놈으로의 전위 - Google Patents

아마이엘로이스로부터의 트랜스포사제를 이용한 핵산 작제물의 진핵세포 게놈으로의 전위 Download PDF

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KR20210144861A
KR20210144861A KR1020217035246A KR20217035246A KR20210144861A KR 20210144861 A KR20210144861 A KR 20210144861A KR 1020217035246 A KR1020217035246 A KR 1020217035246A KR 20217035246 A KR20217035246 A KR 20217035246A KR 20210144861 A KR20210144861 A KR 20210144861A
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스리다르 고빈다라얀
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Abstract

본 발명은 이종성 유전자의 고발현을 위한 폴리뉴클레오티드 벡터를 제공한다. 일부 벡터가 발현을 추가로 개선시키는 신규한 트랜스포존 및 트랜스포사제를 추가로 포함한다. 핵산을 세포의 DNA에 안정적으로 도입시키기 위한 유전자 전달 시스템에 사용될 수 있는 벡터가 추가로 개시된다. 유전자 전달 시스템이 방법 예를 들어, 유전자 발현, 바이오프로세싱, 유전자 요법, 삽입 돌연변이유발 또는 유전자 발견에 사용될 수 있다.

Description

아마이엘로이스로부터의 트랜스포사제를 이용한 핵산 작제물의 진핵세포 게놈으로의 전위
관련 출원에 대한 교차 참조
본 출원은 2019년 4월 8일에 출원된 미국 가출원 번호 62/831,097; 2019년 7월 12일에 출원된 미국 가출원 번호 62/873,342; 및 2020년 3월 17일에 출원된 미국 가출원 번호 62/990,568에 대한 우선권을 주장하며, 각각은 모든 목적상 그 전체가 참조로 포함된다.
서열 목록에 대한 참조
본 출원은 참조로 포함된 2020년 4월 6일에 생성된 2,392,133 바이트의 546917SEQLST.TXT라는 txt 파일에 개시된 서열을 참고한다.
1. 발명의 분야
본 발명의 분야는 표적 세포의 게놈을 안정적으로 변형시키기 위한 DNA 벡터의 배열, 및 비-천연 프랜스포손 및 트랜스포사제의 용도에 관한 것이다.
2. 발명의 배경
세포의 게놈에 통합된 폴리뉴클레오티드에 인코딩된 유전자의 발현 수준은 폴리뉴클레오티드 내의 서열 요소의 배열에 의존적이다. 통합 효율성 및 이에 따른 각 게놈에 통합되는 폴리뉴클레오티드의 복사체 수, 및 통합이 발생하는 게놈 유전자좌 또한 폴리뉴클레오티드에 인코딩된 유전자의 발현 수준에 영향을 끼친다. 폴리뉴클레오티드가 표적 세포의 게놈에 통합될 수 있는 효율성은 종종 트랜스포존 내에 폴리뉴클레오티드를 배치시킴으로써 증가될 수 있다.
트랜스포존은 트랜스포사제에 의해 인식되는 2개의 말단부를 포함한다. 트랜스포사제는 트랜스포존에 작용하여 한 DNA 분자로부터 이를 제거하고 이를 또 다른 DNA 분자에 통합시킨다. 2개의 트랜스포존 말단부 사이의 DNA는 트랜스포존 말단과 함께 트랜스포사제에 의해 전위된다. 트랜스포사제에 의해 인식되고 전위되도록 한 쌍의 트랜스포존 말단에 측접된 이종성 DNA는 본원에서 합성 트랜스포존으로서 언급된다. 진핵 세포의 핵으로의 합성 트랜스포존 및 상응하는 트랜스포사제의 도입은 세포의 게놈 내로의 트랜스포존의 전위를 발생시킬 수 있다. 이러한 결과는 형질전환 효율을 증가시키고, 통합된 이종성 DNA로부터 발현 수준을 증가시킬 수 있기 때문에 유용하다. 이와 같이, 과활성 트랜스포사제 및 트랜스포존이 당업계에 요구된다.
피기백(piggyBack)-유사 트랜스포사제에 의한 전위는 완벽하게 가역적이다. 트랜스포존은 처음에는 수령체 DNA 분자의 통합 표적 서열에 통합되며, 그 동안 표적 서열은 트랜스포존 역 말단 반복부(ITR)의 각 말단에서 복제된다. 후속 전위는 트랜스포존을 제거하고 표적 서열 중복 및 트랜스포존이 제거된 상태에서 수령체 DNA를 이전 서열로 복원한다. 그러나, 이는 트랜스포존이 통합된 게놈으로부터 트랜스포존을 제거하기에 충분하지 않은데, 이는 트랜스포존이 게놈에서 제1 통합 표적 서열로부터 절제되지만 제2 통합 표적 서열 내로 전위될 가능성이 높기 때문이다. 반면에 통합(또는 전위) 기능이 결여된 트랜스포사제는 제1 표적 서열로부터 트랜스포존을 절제할 수 있지만, 제2 표적 서열로 통합할 수는 없을 것이다. 따라서, 통합-결여 트랜스포사제는 트랜스포존의 게놈 통합을 역전시키는데 유용한다.
트랜스포사제에 대한 한 가지 적용은 진핵생물 게놈의 조작을 위한 것이다. 그러한 조작은 게놈 내로 하나 초과의 상이한 폴리뉴클레오티드의 통합을 필요로 할 수 있다. 이러한 통합은 동시적이거나 순차적일 수 있다. 제1 트랜스포사제에 의한 제1 이종성 폴리뉴클레오티드를 포함하는 제1 트랜스포존의 게놈으로의 전위에 이어서 제2 트랜스포사제에 의한 제2 이종성 폴리뉴클레오티드를 포함하는 제2 트랜스포존의 동일한 게놈으로의 전위가 후속되는 경우, 제2 트랜스포사제는 제1 트랜스포존을 인식 및 전위시키지 않는 것이 유리하다. 이는 게놈 내의 폴리뉴클레오티드 서열의 위치가 상기 폴리뉴클레오티드에 인코딩된 유전자의 발현성에 영향을 미치므로, 제2 트랜스포사제에 의한 다른 염색체 위치로의 제1 트랜스포존의 전위는 제1 이종성 폴리뉴클레오티드에 인코딩된 임의의 유전자의 발현 특성을 변경할 수 있기 때문이다. 따라서, 세트 내의 트랜스포사제가 단지 이들의 상응하는 트랜스포존만을 인식하고 전위시키고, 세트 내의 임의의 다른 트랜스포존은 인식하지 않는 트랜스포존 및 상응하는 트랜스포사제 세트가 필요하다.
1983년에 발견된 이래로 로퍼 나방 트리코플뤼시아니(Trichoplusia ni)의 피기백 트랜스포존과 트랜스포사제는 많은 다양한 유기체의 표적 세포 게놈에 이종성 DNA를 삽입하는데 널리 사용되었다. 피기백 시스템은 다음과 같은 이유로 특히 가치있는 트랜스포사제 시스템이다: "광범위한 유기체에서의 활성, 고효율로 다수의 대형 이식유전자를 통합하는 능력, 활성 손실 없이 트랜스포사제에 도메인을 추가하는 능력, 및 풋프린트 돌연변이를 남기지 않고 게놈에서 절제하는 능력" (Doherty et al., Hum. Gene Ther. 23, 311-320 (2012), at p. 312, LHC, ¶ 2).
피기백 시스템의 가치와 다양성은 다른 활성 피기백-유사 트랜스포존(일반적으로 피기백-유사 요소 또는 PLE라고 함)을 확인하려는 상당한 노력에 영감을 주었지만 대부분 성공하지 못하였다. 피기백은 트랜스제네시스에 사용되는 가장 인기 있는 트랜스포존 중 하나이기 때문에 새로운 활성 PLE에 대한 조사는 많은 관심을 받았다. 그러나 현재까지 단지 몇개의 활성 PLE만이 보고되었다."(Luo et al., BMC Molecular Biology 15, 28 (2014) http://www.biomedcentral.com/1471-2199/15/28. p.4 of 12, RHC, ¶ 1 "Discussion").
서열 데이터베이스에 많은 수의 피기백 트랜스포존 및 트랜스포사제의 동족체가 있지만, 다음 발췌문에서 설명되는 바와 같이 숙주에 해로운 활성을 피하기 위해 대다수가 숙주에 의해 비활성화되기 때문에 활성이 거의 없는 것으로 확인되었다: "관련 피기백 전위성 요소는 인간을 포함한 식물, 균류 및 동물에서 발견되었지만[125], 이들은 아마도 돌연변이로 인해 비활성화된다."(Munoz-Lopez & Garcia-Perez, Current Genomics 11, 115-128(2010) p. 120, RHC, ¶ 1). 트랜스포존은 게놈을 침범하고, 후속하여 진화하는 동안 게놈 전체에 퍼지는 것으로 여겨진다. 트랜스포존의 "이기적'' 이동성은 숙주에게 해롭다; 따라서, 그들은 자연 선택을 통해 숙주에 의해 제거되거나 비활성화된다. 무해한 트랜스포존조차도 보존적 선택이 없기 때문에 결국 활성을 손실한다. 따라서, 일반적으로 트랜스포존은 숙주에서 수명이 짧고, 후속하여 게놈에서 화석이 된다." (Hikosaka et al., Mol. Biol. Evol. 24, 2648-3656 (2007) at p. 2648, LHC, ¶ 1 "Introduction"). "게놈에서 전위 요소의 빈번한 이동은 해롭다(Belancio et al., 2008; Deininger & Batzer, 1999; Le Rouzic & Capy, 2006; Oliver & Greene, 2009). 결과적으로 대부분의 전이가능한 요소는 새로운 숙주를 침범한 직후 비활성화된다."(Luo et al., Insect Science 18, 652-662(2011) p. 660, LHC, ¶1).
세 가지 종류의 피기백-유사 요소가 발견되었다: (1) 로퍼 나방의 원래 피기백과 매우 유사한 요소(일반적으로 뉴클레오티드 수준에서 >95% 동일성),(2) 적당히 관련된 요소(일반적으로 아미노산 수준에서 30-50% 동일함), 및 (3) 관련이 매우 먼 것들(Wu et al., Insect Science 15, 521-528(2008) at p. 521, RHC ¶ 2).
로퍼 나방 트랜스포사제와 고도로 관련된 피기백-유사 트랜스포사제는 여러 그룹에 의해 설명되었다. 이들은 매우 고도로 보존된다. 원래의 피기백과 매우 유사한 트랜스포사제 서열(95-98% 뉴클레오티드 동일성)은 초파리 박트로세라 도르살리스(Bactrocera dorsalis)의 3가지 다른 균주에서 보고되었다(Handler & McCombs, Insect Molecular Biology 9, 605-612, (2000)). 비교적 보존된 피기백 서열이 다른 박트로세라 종에서 발견되었다(Bonizzoni et al., Insect Molecular Biology 16, 645-650(2007)). 두 종의 야행성 나방(헬리코베르파 제아(Helicoverpa zea) 및 헬리코베르파 아르미게라(Helicoverpa armigera))과 로퍼 나방 트리코플뤼시아니의 다른 균주는 원래의 피기백 서열에 대해 93-100% 뉴클레오티드 동일성을 갖는 피기백 트랜스포사제의 게놈 복사체를 가졌다(Zimowska & Handler, Insect Biochemistry and Molecular Biology , 36, 421-428(2006)). 지모우스카 & 핸들러(Zimowska & Handler)는 또한 두 헬리코베르파 종에서 훨씬 더 현저하게 변이된 (및 절두된) 버젼의 피기백 트랜스포사제는 물론 군충 스포듭테라 프루기퍼다(armyworm Spodptera frugiperda)의 상동체의 여러 복사체를 발견하였다. 이들 그룹 중 어느 그룹도 이러한 트랜스포사제에 대한 어떠한 활성도 측정하려고 시도하지 않았다. 우(Wu) 등(2008)(상기 참조)은 로퍼 나방 피기백과 99.5% 서열 동일성을 갖는 맥둔노우기아 크라스시시그나(Macdunnoughia crassisigna)로부터 트랜스포사제를 분리하는 것을 보고하였다. 그들은 또한 절제 및 전위 둘 모두를 측정할 수 있음을 보여줌으로써 이 트랜스포존과 트랜스포사제가 활성임을 입증하였다. 그들의 토론은 이전 결과를 하기와 같이 요약하였다: "기타 밀접하게 관련된 것으로 보고된 다른 IFP2 클래스 서열은 다양한 박트로세라 종, T. 니 게놈, 헬리코베르파 아르미게라, 및 H. 제아에 있었다(Handler & McCombs, 2000; Zimowska & Handler, 2006; Bonizzoni et al., 2007). 이들 서열은 피기백-유사 요소의 부분 단편이었고, 이들 대부분은 절두되거나 무작위 돌연변이가 누적되어 비활성화되었다."(Wu et. al., Insect Science 15, 521-528(2008) p. 526, LHC, ¶3.)
단순히 서열을 보고 로퍼 나방 효소와 적당히 관련이 있는 것으로 활성 피기백-유사 트랜스포사제를 식별하는 것은 매우 어려운 것으로 입증되었다. 필요한 것으로 알려진 특징이 존재한다: 전장 오픈 리딩 프레임, 촉매적 아스파르테이트 잔기 및 온전한 ITR은 활성이 예측되는 것으로 입증되지 않았다. "진핵생물에서 매우 다양한 PLE는 게놈 서열 데이터의 컴퓨터 분석에서 문서화되었다[인용 생략]. 그러나, 기능과 일치하는 온전한 구조를 갖는 몇몇 요소가 분리되었으며, 단지 원래의 IFP2 피기백은 관례적인 트랜스제네시스를 위한 벡터로 개발되었다" (Wu et al., Genetica 139, 149-154 (2011), at p. 152, RHC, ¶ 2.). 난징 대학교("난징 그룹")의 우 등의 그룹은 6년에 걸쳐 여러 논문을 발표하였으며, 각각은 적당히 관련된 피기백 동족체를 확인하였다. 2008년에 난징 그룹은 이들이 상응하는 트랜스포사제에 의해 맥둔노우기아 크라스시시그나 트랜스포존의 절제 및 전위 둘 모두를 측정할 수 있으며, 각각의 후속 논문에서 이들은 신규한 활성 피기백-유사 트랜스포사제를 식별하고자 하는 열망을 표현하였지만, 이들은 단지 절제 활성 및 아피스 고스시피(Aphis gossypii)로부터의 하나의 트랜스포사제에 대해서만 보여준다. 이들은 이러한 트랜스포사제의 유용성이 "추가 실험을 통해 탐구되어야 한다"고 결론지었다(Luo et. al. 2011, p. 660, LHC ¶ 2 "Discussion"). 그러나, 피기백-유사 서열을 다양한 다른 곤충에서 확인한 난징 그룹에서 발표한 다른 논문 어느 것도 어떠한 활성이 발견되었음을 보여주지 못하였다. 캔자스 대학의 그룹은 다른 추정 활성 피기백-유사 트랜스포사제를 확인하는 3개의 논문을 발표하였다. 이 논문 중 어떤 것도 활성 데이터는 보고하지 않았다. 문헌[Wang et al., Insect Molecular Biology 15, 435-443 (2006)]은 담배 봉오리벌레 헬리오티스 비레센스(tobacco budworm Heliothis virescens)의 게놈에서 피기백-유사 서열의 다중 복사체를 발견하였다. 이들 중 다수는 명백한 돌연변이 또는 결실을 갖고 있어 저자가 이들을 후보 활성 트랜스포사제로 간주하지 않게 하였다. 문헌 [Wang et. al., Insect Biochemistry and Molecular Biology 38, 490-498(2008)]은 붉은가루 딱정벌레 트리볼리움 카스타늄(Tribolium castaneum)의 게놈에서 30개 초과의 피기백-유사 서열을 보고하였다. 그들은 "TcPLE1을 제외하고 여기에서 확인된 모든 TcPLE는 추정되는 트랜스포사제 인코딩 영역에 다중 정지 코돈 및/또는 삽입결실이 있기 때문에 분명히 결함이 있다"라고 결론지었다. TcPLE1에 있어서도 "최근 또는 현재의 동원 사례를 뒷받침하는 증거는 없었다" (p. 492, section 3.1, ¶ ¶ 2&3). 왕(Wang)(2010) 등은 PCR을 사용하여 분홍색 도화지벌레 펙티노포라 고스시피엘라(Pectinophora gossypiella)로부터의 피기백-유사 서열을 확인하였다. 또한, 이들은 분명히 결함이 있는 많은 복사체는 물론 저자가 활성과 일치하는 것으로 믿는 특징을 가진 한 트랜스포사제를 발견하였다(page 179, RHC, ¶ 2). 그러나, 트랜스포사제 활성을 나타내는 후속 보고서는 찾아볼 수 없었다. 다른 그룹 또한 활성 피기백-유사 트랜스포사제를 확인하려고 시도하였다. 이들 보고서는 확인된 피기백-유사 요소가 활성에 대한 테스트를 하고 있는 것으로 결론내지만 성공에 대한 후속 보고서는 존재하지 않는다. 예를 들어, 사카(Sarkar)(2003) 등은 신규한 활성 피기백-유사 트랜스포존의 가치를 다시 언급하고 하나를 확인하기 위한 지속적인 노력을 설명하여 논의를 마무리한다: "다양한 곤충에서 원래의 T. 니 피기백 요소의 이동성은 피기백 패밀리 트랜스포존이 곤충 이외의 유기체에서 유용한 유전자 도구인 것으로 입증될 수 있음을 시사한다. 우리는 현재 An. 감비애(AgaPB1)로부터 무손상 피기백 요소를 분리하여 다양한 유기체에서 이들의 이동성을 테스트하고 있다(Mol. Gen. Genomics 270, 173-180 at p. 179, LHC, ¶1). 이러한 추정 활성 트랜스포사제의 추가로 공개된 보고서는 없는 것으로 보인다. 피기백-유사 서열을 찾고 있는 주(Xu) 등은 누에 게놈을 분석하였다(Xu et al., Mol Gen Genomics 276, 31-40 (2006)). 그들은 98개 피기백-유사 서열을 발견하였으며, 추정 트랜스포사제 서열 및 ITR 서열의 다양한 컴퓨터 분석을 수행하였다. 이들은 다음과 같이 결론내렸다: "우리는 B. 모리로부터의 수개의 무손상 피기백-유사 요소를 분리하였으며, 현재 이들의 활성 및 이들을 변형 벡터로 사용할 가능성을 조사하고 있다" (p 38, RHC, ¶3). 이러한 추정 활성 트랜스포사제의 추가로 공개된 보고서는 없는 것으로 보인다.
4개의 출판된 논문이 제3 부류의 관련이 먼 피기백-유사 트랜스포사제를 논의하고 있다. 이들 중 처음 3개는 반응의 절제 부분만을 입증하며, 이는 완전한 전위와 상이하다는 것을 인정한다. 문헌 [Hikosaka et. al., Mol Biol Evol 24, 2648-2656(2007)]은 "본 연구에서 우리는 Xtr-Uribo2 Tpase가 표적 트랜스포존에 대한 절제 활성을 가지고 있음을 입증하였으나, 지금까지 게놈으로의 절제된 표적의 통합에 대한 증거는 없다" (page 2654, RHC, ¶2)라고 보고하고 있다. 문헌 [Luo et. al., Insect Science 18, 652-662 (2011)]은 다음과 같이 보고하였다: "이들 결과는 요소의 컷 앤 페이스트(cut and paste) 이동의 첫 번째 단계를 매개하는 Ago-PLE1.1 트랜스포사제의 활성을 입증하였다" (페이지 658, LHC, ¶1). 문헌 [Daimon et. al., Genome 53, 585-593 (2010)]은 트랜스포사제 시스템 야부사베-1 및 야부사베-W에 대해 논의하였다. 비록 다이아몬 등이 PCR에 의한 절제 사례 검출을 보고하였지만, 이들은 요소가 절제된 단일 회수 플라스미드를 식별하지 않으면서 야부사메-1 및 야부사메-W의 절제를 위해 약 100,000개의 회수 플라스미드를 스크리닝하는 것을 또한 보고하였다. 대조적으로 다이아몬은 야생형 피기백 효소의 전위 빈도를 약 0.3-1.4로 보고하였다. 따라서, 다이아몬 등으로부터는 야부사베-1 또는 -W의 절제 빈도가 0.001%(1:100,000) 미만인 것으로 보인다. 이는 야생형 피기백 효소로 달성될 수 있는 것보다 적어도 100-1000배 적으며, 야생형보다 10배 더 높은 전위를 달성하는 사용가능한 유전자 조작된 피기백 트랜스포사제 변이체보다 훨씬 적다. 다이아몬 등의 야바수메-1에 대한 암시적 전위 빈도는 또한 포유동물 세포에서 무작위 통합 빈도(0.1% 정도임)보다 100배 더 낮다. 따라서, 다이아몬 등은 야부사메-1이 본질적으로 비활성이며, 유전자 조작 도구로서 유용하지 않을 것임을 보여준다. 이러한 견해는 다이아몬 등의 다음과 같은 결론의 기초가 될 수 있다: "우리는 고도로 민감한 PCR-기반 검정에서 절제 사례를 검출할 수 있지만, 우리의 데이터는 두 요소 모두가 이들의 절제 활성을 거의 완전히 상실하였음을 나타낸다". 이는 또한 Uribo2 및 Ago-PLE1.1의 활성을 보여주는데 사용된 PCR-기반 절제 검정이 표적 세포의 게놈에 이종성 DNA를 삽입하는데 유용할 전위 활성을 예측하지 못한다는 것을 시사한다. 트리코플뤼시아니로부터의 원래의 피기백 트랜스포사제와 관련이 먼 트랜스포사제의 제3 카테고리의 완전 활성 피기백-유사 트랜스포사제(절제 및 통합 둘 모두에 적합)의 유일한 보고는 박쥐 마이오티스 루시푸구스(Myotis lucifugus)로부터의 것이다(Mitra et. al., Proc. Natl. Acad. Sci. 110, 234-239 (2013)). 이들 저자들은 효모 시스템을 사용하여 박쥐 트랜스포사제에 대한 절제 및 전위 활성 둘 모두를 입증하였다. 여기에 설명된 모든 작업은 많은 수의 후보 서열이 있음에도 불구하고 완전히 활성인 피기백-유사 트랜스포사제를 식별하는 것이 극도로 어려웠다는 것을 보여준다. 따라서, 새로운 피기백-유사 트랜스포존 및 이들의 상응하는 트랜스포사제가 요구된다.
3. 발명의 개요
표적 세포 게놈에 안정적으로 통합되는 폴리뉴클레오티드 작제물로부터의 이종성 유전자 발현은 발현 폴리뉴클레오티드를 한 쌍의 트랜스포존 말단(트랜스포사제에 의해 인식되고 전위되는 서열 요소) 사이에 배치함으로써 개선될 수 있다. 한 쌍의 트랜스포존 말단 사이에 삽입된 DNA 서열은 한 DNA 분자로부터 트랜스포사제에 의해 절제되어 제2 DNA 분자에 삽입될 수 있다. 로퍼 나방 트리코플뤼시아니로부터 유래되지 않은 신규한 피기백-유사 트랜스포존-트랜스포사제 시스템이 개시된다. 이는 나발 오렌지웜 나방 아마이엘로이스 트랜시텔라(아마이엘로이스 트랜스포사제)로부터 유래된다. 아마이엘로이스 트랜스포존은 트랜스포존 말단으로서 기능하며, 세포의 DNA에 핵산을 안정적으로 도입하기 위한 유전자 전달 시스템으로서 이러한 트랜스포존 말단을 인식하고 이에 작용하는 상응하는 아마이엘로이스 트랜스포사제와 함께 사용될 수 있는 서열을 포함한다. 본 발명의 유전자 전달 시스템은 비제한적으로, 진핵 세포의 게놈 조작, 이종성 유전자 발현, 유전자 요법, 세포 요법, 삽입 돌연변이유발 또는 유전자 발견을 포함하는 방법에 사용될 수 있다.
전위는, 이종성 프로모터에 작동가능하게 연결된, 아마이엘로이스 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 포함하는 폴리뉴클레오티드로서, 트랜스포사제의 아미노산 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리뉴클레오티드를 사용하여 수행될 수 있다. 이종성 프로모터는 진핵 세포에서 활성일 수 있다. 이종성 프로모터는 포유동물 세포에서 활성일 수 있다. mRNA는, 아미노산이 시험관내 전사 반응에서 활성인 이종성 프로모터에 작동가능하게 연결된 아마이엘로이스 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 포함하는 폴리뉴클레오티드로서, 트랜스포사제의 아미노산 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리뉴클레오티드로부터 제조될 수 있다. 트랜스포사제는 SEQ ID NO: 18의 서열과 비교해 표 1의 C 및 D 열에 나타낸 돌연변이를 포함할 수 있다. 트랜스포사제는 SEQ ID NO: 18의 서열과 비교해, 79, 95, 115, 116, 121, 139, 166, 179, 187, 198, 203, 211, 238, 273, 304, 329, 345, 362, 366, 408, 416, 435, 458, 475, 483, 491, 529, 540, 560 및 563으로부터 선택된 아미노산 위치에서의 돌연변이를 포함할 수 있다. 트랜스포사제는 SEQ ID NO: 18의 서열과 비교해, D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K로부터 선택되는 돌연변이를 포함할 수 있으며, 트랜스포사제는 상기 군으로부터 선택되는 적어도 2, 3, 4 또는 5개를 임의적으로 포함한다. 트랜스포사제의 아미노산 서열은 SEQ ID NO: 96-170에서 선택될 수 있다. 트랜스포사제는 SEQ ID NO: 192로부터 트랜스포존을 절제하거나 전위시킬 수 있다. 트랜스포사제의 절제 활성 또는 전위 활성은 SEQ ID NO: 18의 활성보다 적어도 2배 더 높고, 임의적으로 2 내지 10배 더 높다. 트랜스포사제의 오픈 리딩 프레임의 코돈은 포유동물 세포 발현을 위해 선택될 수 있다. 단리된 mRNA는 아미노산 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리펩티드를 인코딩할 수 있으며, 여기에서 mRNA 서열은 mRNA와 SEQ ID NO: 929 사이의 상응하는 위치에서 SEQ ID NO: 929와 비교해 적어도 10개의 동의 코돈 차이를 포함하며, mRNA 서열은 mRNA와 SEQ ID NO: 929 사이의 상응하는 위치에서 SEQ ID NO: 929와 비교해 적어도 10개의 동의 코돈 차이를 포함하며, 임의적으로 상응하는 위치에서 mRNA의 코돈은 포유동물 세포 발현을 위해 선택된다. 트랜스포사제를 인코딩하는 오픈 리딩 프레임은 트랜스포사제에 융합된 이종성 핵 국소화 서열을 추가로 인코딩할 수 있다. 트랜스포사제를 인코딩하는 오픈 리딩 프레임은 트랜스포사제에 융합된 이종성 DNA 결합 도메인(예를 들어, Crispr Cas 시스템 또는 아연 핑거 단백질, 또는 TALE 단백질로부터 유래됨)을 추가로 인코딩할 수 있다. 비-자연 발생 폴리뉴클레오티드는 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리펩티드를 인코딩할 수 있다.
아마이엘로이스 트랜스포존은 이종성 폴리뉴클레오티드에 측접한 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함한다. 트랜스포존은 이종성 폴리뉴클레오티드의 한 측에서 SEQ ID NO: 13과 적어도 90% 동일한 서열 및 다른 측에서 SEQ ID NO: 16과 적어도 90% 동일한 서열을 추가로 포함할 수 있다. 이종성 폴리뉴클레오티드는 진핵 세포에서 활성인 이종성 프로모터를 포함할 수 있다. 프로모터는 i) 오픈 리딩 프레임; ii) 선택가능 마커를 인코딩하는 핵산; iii) 카운터-선택가능 마커를 인코딩하는 핵산; iii) 조절 단백질을 인코딩하는 핵산; iv) 억제성 RNA를 인코딩하는 핵산 중 적어도 하나 이상에 작동가능하게 연결될 수 있다. 이종성 프로모터는 SEQ ID NO: 474-558로부터 선택되는 서열을 포함할 수 있다. 이종성 폴리뉴클레오티드는 진핵 세포에서 활성인 이종성 인핸서를 포함할 수 있다. 이종성 인핸서는 SEQ ID NO: 453-473으로부터 선택될 수 있다. 이종성 폴리뉴클레오티드는 진핵 세포에서 스플라이싱 가능한 이종성 인트론을 포함할 수 있다. 이종성 인트론의 뉴클레오티드 서열은 SEQ ID NO: 561-621로부터 선택될 수 있다. 이종성 폴리뉴클레오티드는 격리자 서열을 포함할 수 있다. 격리자의 핵산 서열은 SEQ ID NO: 435-441로부터 선택될 수 있다. 이종성 폴리뉴클레오티드는 2개의 오픈 리딩 프레임을 포함할 수 있으며, 이들 각각은 개별 프로모터에 작동가능하게 연결되어 있다. 이종성 폴리뉴클레오티드는 SEQ ID NO: 745-928로부터 선택되는 서열을 포함할 수 있다. 이종성 폴리뉴클레오티드는 선택가능 마커를 포함하거나 인코딩할 수 있다. 선택가능 마커는 글루타민 합성효소, 디하이드로폴레이트 환원효소, 퓨로마이신 아세틸트랜스퍼라제 효소, 블라스티시딘 아세틸트랜스퍼라제 효소, 하이그로마이신 B 포스포트랜스퍼라제 효소, 아미노글리코시드 3'-포스포트랜스퍼라제 효소 및 형광 단백질로부터 선택될 수 있다. 게놈이 이종성 폴리뉴클레오티드에 측접하는 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 진핵 세포는 본 발명의 구체예이다. 세포는 동물 세포, 포유동물 세포, 설치류 세포 또는 인간 세포일 수 있다.
트랜스포존은 (a) 이종성 폴리뉴클레오티드에 측접한 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 트랜스포존을 세포 내에 도입하고, (b) 서열이 SEQ ID NO: 18과 적어도 90% 동일한 트랜스포사제를 세포 내에 도입함으로써, 진핵 세포의 게놈 내로 통합될 수 있으며, 여기서 트랜스포사제는 이종성 폴리뉴클레오티드에 측접한 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 게놈을 생성하기 위해 트랜스포존을 전위시킨다. 트랜스포사제는 트랜스포사제를 인코딩하는 폴리뉴클레오티드로서 도입될 수 있으며, 폴리뉴클레오티드는 mRNA 분자 또는 DNA 분자일 수 있다. 트랜스포사제는 단백질로서 도입될 수 있다. 이종성 폴리뉴클레오티드는 또한 선택가능 마커를 인코딩할 수 있으며, 방법은 선택가능 마커를 포함하는 세포를 선택하는 단계를 추가로 포함할 수 있다. 세포는 동물 세포, 포유동물 세포, 설치류 세포 또는 인간 세포일 수 있다. 인간 세포는 인간 면역 세포, 예를 들어 B-세포 또는 T-세포일 수 있다. 이종성 폴리뉴클레오티드는 키메라 항원 수용체를 인코딩할 수 있다. 폴리펩티드는 진핵 세포의 게놈에 통합된 트랜스포존으로부터 발현될 수 있다. 폴리펩티드는 정제될 수 있다. 정제된 폴리펩티드는 약학적 조성물에 혼입될 수 있다.
도 1. 아마이엘로이스 트랜스포존의 구조
아마이엘로이스 트랜스포존은 이종성 폴리뉴클레오티드에 측접한 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 포함한다. 좌측 트랜스포존 말단은 (i) 종종 5'-TTAA-3'인 좌측 표적 서열(많은 다른 표적 서열이 더 낮은 빈도로 사용됨)(Li et al., 2013. Proc. Natl. Acad. Sci vol. 110, no. 6, E478-487); (ii) 좌측 ITR(예를 들어, SEQ ID NO: 9) 및 (iii) (임의적으로) 추가의 좌측 트랜스포존 말단 서열(예를 들어, SEQ ID NO: 13)을 포함한다. 우측 트랜스포존 말단은 (i) (임의적으로) 추가 우측 트랜스포존 말단 서열(예를 들어, SEQ ID NO: 16); (ii) 좌측 ITR의 완전하거나 불완전한 반복부이지만 좌측 ITR에 대해 반전된 방향인 우측 ITR(예를 들어, SEQ ID NO: 10) 및 (iii) 전형적으로 좌측 표적 서열과 동일한 우측 표적 서열을 포함한다.
5. 발명의 상세한 설명
5.1 정의
단수 형태("a', "an" 및 "the")의 사용은 문맥이 명백히 달리 지시하지 않는 한 복수의 지시대상을 포함한다. 따라서, 예를 들어, "폴리뉴클레오티드"에 대한 언급은 복수의 폴리뉴클레오티드를 포함하며, "기질"에 대한 언급은 복수의 이러한 기질을 포함하며, "변이체"에 대한 언급은 복수의 변이체를 포함하며, 기타 등등이 있다.
"연결된", "부착된", "결합된" 및 "컨쥬게이션된"과 같은 용어는 본원에서 상호교환가능하게 사용되며, 문맥상 명백하게 달리 지시하지 않는 한 직접 및 간접 연결, 부착, 결합 또는 컨쥬게이션을 포함한다. 값의 범위가 인용되는 경우, 해당 범위의 인용된 상한 및 하한 사이의 각각의 중간 정수 값 및 이의 각 분수가 또한 이러한 값 사이의 각 하위 범위와 함께 또한 구체적으로 개시되는 것으로 이해되어야 한다. 임의의 범위의 상한 및 하한은 독립적으로 범위에 포함되거나 제외될 수 있으며, 둘 중 하나 또는 둘 모두가 포함되거나 어느 것도 포함되지 않는 각 범위도 또한 본 발명에 포함된다. 논의되는 값에 고유한 한계가 있는 경우, 예를 들어 성분이 0 내지 100%의 농도로 존재할 수 있는 경우 또는 수용액의 pH가 1 내지 14의 범위일 수 있는 경우, 이러한 고유 한계는 구체적으로 개시된다. 값이 명시적으로 인용되는 경우, 인용된 값과 거의 동일한 정량 또는 양인 값도 본 발명의 범위 내에 있음을 이해해야 한다. 조합이 개시되는 경우, 해당 조합 요소의 각 하위 조합 또한 구체적으로 개시된 것이며, 본 발명의 범위 내에 있다. 반대로, 상이한 요소 또는 요소의 군이 개별적으로 개시되는 경우, 이들의 조합 또한 개시된다. 발명의 임의의 요소가 복수의 대안을 갖는 것으로 개시되는 경우, 각각의 대안이 단독으로 또는 다른 대안과의 임의의 조합으로 배제된 발명의 예도 또한 본원에 개시된다; 발명의 하나 초과의 요소가 그러한 배제를 가질 수 있으며, 그러한 배제를 갖는 요소의 모든 조합이 본원에 개시된다.
달리 정의되지 않는 한, 본원에서 사용되는 모든 기술 및 과학 용어는 본 발명이 속하는 분야의 당업자에 의해 일반적으로 이해되는 것과 동일한 의미를 갖는다. 문헌 [Singleton, et al., Dictionary of Microbiology and Molecular Biology, 2nd Ed., John Wiley and Sons, New York (1994), and Hale & Marham, The Harper Collins Dictionary of Biology, Harper Perennial, NY, 1991]은 본 발명에 사용된 많은 용어의 일반적인 사전을 숙련자에게 제공한다. 본원에 기재된 것과 유사하거나 동등한 임의의 방법 및 재료가 본 발명의 실시 또는 시험에 사용될 수 있지만, 바람직한 방법 및 재료가 기재된다. 달리 나타내지 않는 한, 핵산은 5'에서 3' 방향으로 왼쪽에서 오른쪽으로 작성된다; 아미노산 서열은 각각 아미노에서 카르복시 방향으로 왼쪽에서 오른쪽으로 작성된다. 바로 아래에 정의되는 용어는 전체로서 명세서를 참조하여 보다 완전하게 정의된다.
폴리뉴클레오티드의 "배열"은 폴리뉴클레오티드 내의 기능적 서열 요소, 및 이러한 요소의 순서 및 방향을 의미한다.
용어 "상응하는 트랜스포존" 및 "상응하는 트랜스포사제"는 트랜스포사제와 트랜스포존 사이의 활성 관계를 나타내기 위해 사용된다. 트랜스포사제는 이의 상응하는 트랜스포존을 전위시킨다. 많은 트랜스포사제가 단일 트랜스포존에 상응할 수 있으며, 많은 트랜스포존이 단일 트랜스포사제에 상응할 수 있다.
용어 "카운터-선택가능 마커"는 숙주 세포에 선택적인 단점을 부여하는 폴리뉴클레오티드 서열을 의미한다. 카운터-선택가능 마커의 예는 sacB, rpsL, tetAR, pheS, thyA, gata-1, ccdB, kid 및 바르나제(barnase)를 포함한다 (Bernard, 1995, Journal/Gene, 162: 159-160; Bernard et al., 1994. Journal/Gene, 148: 71-74; Gabant et al., 1997, Journal/Biotechniques, 23: 938-941; Gababt et al., 1998, Journal/Gene, 207: 87-92; Gababt et al., 2000, Journal/ Biotechniques, 28: 784-788; Galvao and de Lorenzo, 2005, Journal/Appl Environ Microbiol, 71: 883-892; Hartzog et al., 2005, Journal/Yeat, 22:789-798; Knipfer et al., 1997, Journal/Plasmid, 37: 129-140; Reyrat et al., 1998, Journal/Infect Immun, 66: 4011-4017; Soderholm et al., 2001, Journal/Biotechniques, 31: 306-310, 312; Tamura et al., 2005, Journal/ Appl Environ Microbiol, 71: 587-590; Yazynin et al., 1999, Journal/FEBS Lett, 452: 351-354). 카운터-선택가능 마커는 종종 특정 상황에서 선택적인 단점을 부여한다. 예를 들어, 이들은 숙주 세포의 환경에 추가될 수 있는 화합물에 대한 민감성을 부여할 수 있거나, 이들은 한 유전자형을 갖는 숙주를 치사시킬 수 있지만 다른 유전자형을 가진 숙주는 치사시키지 않을 수 있다. 카운터-선택가능 마커를 가지고 있는 세포에 선택적인 불리함을 부여하지 않는 조건은 "허용"으로 설명된다. 카운터-선택가능 마커를 가지고 있는 세포에 선택적인 불리함을 부여하는 조건은 "제한"으로 설명된다.
용어 "커플링 요소" 또는 "번역 커플링 요소"는 제1 폴리펩티드의 발현이 제2 폴리펩티드의 발현에 연결되도록 하는 DNA 서열을 의미한다. 내부 리보솜 진입 부위 요소(IRES 요소) 및 시스-작용 가수분해효소 요소(CHYSEL 요소)는 커플링 요소의 예이다.
용어 "DNA 서열", "RNA 서열" 또는 "폴리뉴클레오티드 서열"은 인접 핵산 서열을 의미한다. 서열은 수천 또는 수십만 염기쌍의 전장 게놈 서열에 대해 2 내지 20개 뉴클레오티드 길이의 올리고뉴클레오티드일 수 있다.
용어 "발현 작제물"은 RNA를 전사하도록 설계된 임의의 폴리뉴클레오티드를 의미한다. 예를 들어, 다운스트림 유전자, 코딩 영역 또는 폴리뉴클레오티드 서열(예를 들어, 폴리펩티드 또는 단백질을 인코딩하는 cDNA 또는 게놈 DNA 단편, 또는 RNA 이펙터 분자, 예를 들어 안티센스 RNA, 트리플렉스-형성 RNA, 리보자임, 인위적으로 선택된 고친화성 RNA 리간드(압타머), 이중 가닥 RNA, 예를 들어 스템-루프 또는 헤어핀 dsRNA를 포함하는 RNA 분자, 또는 이중-핑거 또는 다중-핑거 dsRNA 또는 마이크로RNA, 또는 임의의 RNA)에 작동가능하게 연결되거나 연결될 수 있는 적어도 하나의 프로모터를 함유하는 작제물. "발현 벡터"는 제2 폴리뉴클레오티드에 작동가능하게 연결될 수 있는 프로모터를 포함하는 폴리뉴클레오티드이다. 발현 작제물의 수령 세포로의 형질감염 또는 형질전환은 세포가 발현 작제물에 의해 인코딩된 RNA 이펙터 분자, 폴리펩티드 또는 단백질을 발현하게 한다. 발현 작제물은 예를 들어 박테리오파지, 아데노바이러스, 아데노-관련 바이러스, 레트로바이러스, 렌티바이러스, 폭스바이러스 또는 헤르페스바이러스로부터 유래된 유전자 조작된 플라스미드, 바이러스, 재조합 바이러스, 또는 인공 염색체일 수 있다. 이러한 발현 벡터는 박테리아, 바이러스 또는 파지로부터의 서열을 포함할 수 있다. 이러한 벡터는 염색체, 에피솜 및 바이러스-유래된 벡터, 예를 들어, 박테리아 플라스미드, 박테리오파지, 효모 에피솜, 효모 염색체 요소 및 바이러스로부터 유래된 벡터, 이들의 조합으로부터 유래된 벡터, 예컨대, 플라스미드 및 박테리오파지 유전자 요소, 코스미드 및 파지미드로부터 유래된 벡터를 포함한다. 발현 작제물은 살아있는 세포에서 복제될 수 있거나, 이는 합성으로 만들어질 수 있다. 본 출원의 목적을 위해, 용어 "발현 작제물", "발현 벡터", "벡터" 및 "플라스미드"는 일반적이고 예시적인 의미에서 본 발명의 적용을 입증하기 위해 상호교환적으로 사용되며, 특정 유형의 발현 작제물로 본 발명을 제한하고자 하는 것은 아니다.
용어 "발현 폴리펩티드"는 발현 작제물 상의 유전자에 의해 인코딩되는 폴리펩티드를 의미한다.
용어 "발현 시스템"은 폴리뉴클레오티드에 의해 인코딩된 하나 이상의 유전자 생성물을 생성하는데 사용되는 임의의 생체내 또는 시험관내 생물학적 시스템을 의미한다.
"유전자"는 프로모터 및 이로부터 RNA 또는 단백질로서 발현될 서열을 포함하는 전사 단위체를 지칭한다. 발현될 서열은 다른 가능성 중에서 게놈 또는 cDNA일 수 있다. 인트론 및 기타 조절 서열과 같은 다른 요소는 존재하거나 존재하지 않을 수 있다.
"유전자 전달 시스템"은 벡터 또는 유전자 전달 벡터, 또는 벡터 내로 클로닝된 전달될 유전자를 포함하는 폴리뉴클레오티드("유전자 전달 폴리뉴클레오티드" 또는 "유전자 전달 작제물")를 포함한다. 유전자 전달 시스템은 또한 유전자 전달 과정을 용이하게 하는 다른 특징을 포함할 수 있다. 예를 들어, 유전자 전달 시스템은 제1 폴리뉴클레오티드가 세포에 진입할 수 있도록 하기 위한 벡터 및 지질 또는 바이러스 패키징 혼합물을 포함할 수 있거나, 트랜스포존을 포함하는 폴리뉴클레오티드 및 트랜스포존의 생산적 게놈 통합을 향상시키기 위해 상응하는 트랜스포사제를 인코딩하는 제2 폴리뉴클레오티드 서열을 포함할 수 있다. 유전자 전달 시스템의 트랜스포사제 및 트랜스포존은 동일한 핵산 분자 또는 상이한 핵산 분자에 있을 수 있다. 유전자 전달 시스템의 트랜스포사제는 폴리뉴클레오티드 또는 폴리펩티드로서 제공될 수 있다.
두 요소는 자연적으로 연관되지 않은 경우 서로에 대해 "이종성"이다. 예를 들어, 이종성 프로모터에 연결된 단백질을 인코딩하는 핵산 서열은 단백질의 발현을 자연적으로 유도하는 프로모터 이외의 프로모터를 의미한다. 트랜스포존 말단 또는 ITR이 측접한 이종성 핵산은 항체 중쇄 또는 경쇄를 포함하는 트랜스포사제 이외의 폴리펩티드를 인코딩하는 핵산과 같은 트랜스포존 말단 또는 ITR에 자연적으로 측접하지 않은 이종성 핵산을 의미한다. 핵산은 세포에서 자연적으로 발견되지 않거나 세포에서 자연적으로 발견되나 기술된 위치와 상이한 위치(예를 들어, 에피솜 또는 상이한 게놈 위치)에서 발견되는 경우 세포에 대해 이종성이다.
용어 "숙주"는 핵산의 수령체일 수 있는 임의의 원핵 또는 진핵 유기체를 의미한다. 본원에 사용된 용어 "숙주"는 유전자 조작될 수 있는 원핵 또는 진핵 유기체를 포함한다. 이러한 숙주의 예에 있어서, 문헌 [Maniatis et al., Molecular Cloning. A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. (1982)] 참조. 본원에 사용된 용어 "숙주", "숙주 세포", "숙주 시스템" 및 "발현 숙주"는 상호교환적으로 사용될 수 있다.
"과활성" 트랜스포사제는 이것이 유래되는 자연 발생 트랜스포사제보다 더욱 활성인 트랜스포사제이다. 따라서, "과활성" 트랜스포사제는 자연 발생 서열이 아니다.
'통합 결함' 또는 "전위 결함"은 이의 상응하는 트랜스포존을 절제할 수 있으나, 상응하는 자연 발생 트랜스포사제보다 더 낮은 빈도로 숙주 게놈 내로 절제된 트랜스포존을 통합시키는 트랜스포사제를 의미한다.
"IRES" 또는 "내부 리보솜 진입 부위"는 캡 구조와 무관하게 리보솜 결합을 직접적으로 촉진하는 특수화된 서열을 의미한다.
'단리된' 폴리펩티드 또는 폴리뉴클레오티드는 자연 환경에서 제거되거나, 재조합 기술을 사용하여 생산되거나, 화학적으로 또는 효소적으로 합성된 폴리펩티드 또는 폴리뉴클레오티드를 의미한다. 본 발명의 폴리펩티드 또는 폴리뉴클레오티드는 정제될 수 있으며, 즉, 본질적으로 임의의 다른 폴리펩티드 또는 폴리뉴클레오티드 및 관련 세포 생성물 또는 기타 불순물을 함유하지 않는다.
용어 "뉴클레오시드" 및 "뉴클레오티드"는 공지된 퓨린 및 피리미딘 염기 뿐만 아니라 변형된 다른 헤테로사이클릭 염기를 함유하는 모이어티를 포함한다. 이러한 변형에는 메틸화된 퓨린 또는 피리미딘, 아실화된 퓨린 또는 피리미딘, 또는 기타 헤테로사이클을 포함한다. 변형된 뉴클레오시드 또는 뉴클레오티드는 또한 예를 들어, 하이드록실 기 중 하나 이상이 할로겐, 지방족 기로 대체되거나, 에테르, 아민 등으로 기능화된 당 모이어티에 대한 변형을 포함할 수 있다. 용어 "뉴클레오티드 단위체"는 뉴클레오시드 및 뉴클레오티드를 포함하는 것으로 의도된다.
"오픈 리딩 프레임" 또는 "ORF"는 아미노산으로 번역될 때 정지 코돈을 함유하지 않는 폴리뉴클레오티드의 일부를 의미한다. 유전자 코드는 3개의 염기쌍 군으로 DNA 서열을 판독하며, 이는 이중 가닥 DNA 분자가 임의의 6개의 가능한 리딩 프레임(3개는 순방향, 3개는 역방향)으로 판독될 수 있음을 의미한다. ORF는 전형적으로 번역이 시작될 수 있는 개시 코돈을 또한 포함한다.
용어 "작동가능하게 연결된"은 한 서열이 다른 서열의 거동을 변형시키도록 2개의 서열 사이의 기능적 연결을 지칭한다. 예를 들어, 핵산 발현 조절 서열(예컨대, 프로모터, IRES 서열, 인핸서 또는 전사 인자 결합 부위의 어레이)을 포함하는 제1 폴리뉴클레오티드 및 제2 폴리뉴클레오티드는 제1 폴리뉴클레오티드가 제2 폴리뉴클레오티드의 전사 및/또는 번역에 영향을 끼치는 경우 작동가능하게 연결된 것이다. 유사하게, 분비 신호 또는 세포하 국소화 신호를 포함하는 제1 아미노산 서열 및 제2 아미노산 서열은 제1 아미노산 서열이 제2 아미노산 서열을 세포하 위치로 분비하거나 국소화시키는 경우 작동가능하게 연결된 것이다.
용어 "오르토고날(orthogonal)"은 두 시스템 간의 상호작용의 결여를 나타낸다. 제1 트랜스포존 및 이의 상응하는 제1 트랜스포사제 및 제2 트랜스포존 및 이의 상응하는 제2 트랜스포사제는 제1 트랜스포사제가 제2 트랜스포존을 절제하거나 전위시키지 않으며, 제2 트랜스포사제가 제1 트랜스포존을 절제하거나 전위시키지 않는 경우 오르토고날이다.
용어 "돌출부" 또는 "DNA 돌출부"는 이중 가닥 DNA 분자의 말단에 있는 단일 가닥 부분을 의미한다. 상보적 오버행은 서로 염기-쌍을 이룰 것들이다.
"피기백-유사 트랜스포사제"는 TBLASTN 알고리즘을 이용하여 확인할 경우 트리코플뤼시아니로부터의 피기백 트랜스포사제(SEQ ID NO: 17)에 대해 적어도 20% 서열 동일성을 가지며, 문헌 [Sakar, A. et al., (2003). Mol. Gen. Genomics 270: 173-180. "Molecular evolutionary analysis of the widespread piggyBac transposon family and related 'domesticated' species"]에 더욱 상세히 기술된 바와 같으며, 최대 정렬시 트리코플뤼시아니 피기백 트랜스포사제의 D268, D346 및 D447에 상응하는 위치에서 아스파르테이트 잔기가 있는 DDE-유사 DDE 모티프를 추가로 특징으로 하는 트랜스포사제를 의미한다. 피기백-유사 트랜스포사제는 또한 높은 빈도로 이들의 트랜스포존을 정확하게 절제하는 능력을 특징으로 한다. "피기백-유사 트랜스포존"은 피기백-유사 트랜스포사제를 인코딩하는 자연 발생 트랜스포존의 트랜스포존 말단과 동일하거나 적어도 80%, 및 바람직하게는 적어도 90, 95, 96, 97, 98 또는 99% 또는 100% 동일한 트랜스포존 말단을 갖는 트랜스포존을 의미한다. 피기백-유사 트랜스포존은 각 말단에 대략 12-16개 염기의 ITR(역방위 말단 반복) 서열을 포함하고, 트랜스포존 통합시 복제되는 통합 표적 서열(표적 부위 복제 또는 표적 서열 복제 또는 TSD)에 상응하는 4개 염기 서열이 양쪽 측면에 측접해 있다. 피기백-유사 트랜스포존 및 트랜스포사제는 아르기로그람마 아그네이트(Argyrogramma agnate) (GU477713), 아노펠레스 감비애(Anopheles gambiae) (XP_312615; XP_320414; XP_310729), 아피스 고스시피(Aphis gossypii) (GU329918), 아시르토시폰 피숨(Acyrthosiphon pisum) (XP_001948139), 아그로티스 입실론(Agrotis ypsilon) (GU477714), 봄빅스 모리(Bombyx mori) (BAD11135), 시오나 인테스티날리스(Ciona intestinalis) (XP_002123602), 칠로 수프레살리스(Chilo suppressalis) (JX294476), 드로소필라 멜라노가스터(Drosophila melanogaster) (AAL39784), 다프니아 풀리카리아(Daphnia pulicaria) (AAM76342), 헬리코베르파 아르미게라(Helicoverpa armigera) (ABS18391), 호모 사피엔스(Homo sapiens) (NP_689808), 헬리오티스 비레센스(Heliothis virescens) (ABD76335), 맥둔노우기아 크라시시그나(Macdunnoughia crassisigna) (EU287451), 마카카 파스시쿨라리스(Macaca fascicularis) (AB179012), 무스 무스쿨루스(Mus musculus) (NP_741958), 펙티노포라 고스시피엘라(Pectinophora gossypiella) (GU270322), 라투스 노르베기쿠스(Rattus norvegicus) (XP_220453), 트리볼리움 카스타늄(Tribolium castaneum) (XP_001814566) 및 트리코플뤼시아니(AAA87375) 및 제노푸스 트로피칼리스(Xenopus tropicalis) (BAF82026)를 포함하는 광범위한 유기체에서 자연 발생하나, 전위 활성은 이들 중 어느 것에 대해서도 거의 설명되지 않았다.
용어 "폴리뉴클레오티드", "올리고뉴클레오티드", "핵산" 및 "핵산 분자"는 임의의 길이의 뉴클레오티드의 중합체 형태를 지칭하기 위해 상호교환적으로 사용되며, 리보뉴클레오티드, 데옥시리보뉴클레오티드, 이들의 유사체, 또는 이들의 혼합물을 포함할 수 있다. 이 용어는 분자의 기본 구조만을 지칭한다. 따라서, 이 용어는 삼중-, 이중- 및 단일-가닥 데옥시리보핵산("DNA") 뿐만 아니라 삼중-, 이중- 및 단일-가닥 리보핵산("RNA")을 포함한다. 이는 또한 예를 들어, 알킬화에 의해 및/또는 캡핑에 의해 변형된 형태 및 변형되지 않은 형태의 폴리뉴클레오티드를 포함한다. 더욱 특히, 용어 "폴리뉴클레오티드", "올리고뉴클레오티드", "핵산" 및 "핵산 분자"는 폴리데옥시리보뉴클레오티드(2-데옥시-D-리보스 함유), 스플라이싱 여부와 관계 없이 tRNA, rRNA, hRNA, siRNA 및 mRNA를 포함하는 폴리리보뉴클레오티드(D-리보스 함유), 퓨린 또는 피리미딘 염기의 N- 또는 C-글리코시드인 다른 유형의 폴리뉴클레오티드, 및 비-뉴클레오티드 백본을 함유하는 기타 폴리머, 예를 들어, 폴리아미드(예를 들어, 펩티드 핵산("PNA")) 및 폴리모르폴리노(뉴겐(Neugene)으로서 the Anti-Virals, Inc., Corvallis, Oreg.로부터 시중에서 입수가능함) 폴리머, 및 폴리머가 DNA 및 RNA에서 발견되는 것과 같은 염기 쌍 및 염기 스택킹을 허용하는 배열의 뉴클레오염기를 함유하는 경우, 다른 합성 서열-특이적 핵산 폴리머를 포함한다. 용어 "폴리뉴클레오티드", "올리고뉴클레오티드", "핵산" 및 "핵산 분자" 사이의 길이에 있어서 의도된 구별은 없으며, 이들 용어는 본원에서 상호교환가능하게 사용된다. 이들 용어는 분자의 기본 구조만을 지칭한다. 따라서, 이러한 용어는 예를 들어, 3'-데옥시-2',5'-DNA, 올리고데옥시리보뉴클레오티드 N3'P5' 포스포르아미데이트, 2'-O-알킬-치환된 RNA, 이중- 및 단일-가닥 DNA 뿐만 아니라 이중- 및 단일- 가닥 RNA, 및 예를 들어, DNA와 RNA 사이 또는 PNA와 DNA 또는 RNA 사이의 하이브리드를 포함하는 이의 하이브리드를 포함하며, 또한 공지된 유형의 변형, 예를 들어 라벨, 알킬화, "캡", 하나 이상의 뉴클레오티드의 유사체로의 치환, 뉴클레오티드간 변형, 예컨대, 예를 들어, 비하전된 결합(예를 들어, 메틸 포스포네이트, 포스포트리에스테르, 포스포르아미데이트, 카르바메이트, 기타 등등), 음으로 하전된 결합(예를 들어, 포스포로티오에이트, 포스포로디티오에이트, 또는 기타 등등) 및 양으로 하전된 결합(예를 들어, 아미노알킬포스포르아미데이트, 아미노알킬포스포트리에스테르)을 갖는 것들, 펜던트 모이어티를 함유하는 것들, 예컨대, 예를 들어, 단백질(효소(예를 들어, 뉴클레아제), 톡신, 항체, 단일 펩티드, 폴리-L-리신, 기타 등등을 포함), 삽입인자를 갖는 것들(예를 들어, 아크리딘, 소랄렌, 기타 등등), (예를 들어, 금속, 방사성 금속, 보론, 산화 금속, 기타 등등의) 킬레이트를 함유하는 것들, 알킬레이트를 함유하는 것들, 변형된 결합을 갖는 것들(예를 들어, 알파 아노머 핵산, 기타 등등), 뿐만 아니라 변형되지 않은 형태의 폴리뉴클레오티드 또는 올리고뉴클레오티드를 포함한다.
"프로모터"는 작동가능하게 연결된 핵산 분자의 전사를 지시하기에 충분한 핵산 서열을 의미한다. 프로모터는 세포 유형-특이적, 조직-특이적 또는 시간-특이적 방식으로 프로모터-의존성 유전자 발현을 조절 가능하게 하기에 충분하거나, 외부 신호 또는 제제에 의해 유도 가능할 수 있는 다른 전사 조절 요소(예를 들어, 인핸서)의 존재 또는 부재하에 사용될 수 있다; 이러한 요소는 유전자의 3' 영역 내부에 또는 인트론 내부에 있을 수 있다. 바람직하게는, 프로모터는 핵산 서열의 발현을 가능하게 하는 방식으로 핵산 서열, 예를 들어 cDNA 또는 유전자 서열, 또는 이펙터 RNA 코딩 서열에 작동가능하게 연결되거나, 프로모터는 전사하고자 하는 선택된 핵산 서열이 편리하게 삽입될 수 있는 발현 카세트에 제공된다. 포유동물 세포에서 활성인 프로모터와 같은 조절 요소는 조절 요소가 도입된 포유동물 세포에서 세포 당 적어도 1개의 전사의 발현 수준을 발생하도록 구성가능한 조절 요소를 의미한다.
용어 "선택가능 마커"는 폴리뉴클레오티드 분절 또는 이의 발현 생성물을 의미하며, 이는 종종 특정 조건 하에 이를 함유하는 분자 또는 세포에 대해 또는 그에 대해 선택하도록 한다. 이들 마커는 RNA, 펩티드 또는 단백질의 활성, 예컨대 비제한적으로, 생산을 인코딩할 수 있거나, RNA, 펩티드, 단백질, 무기 및 유기 화합물 또는 조성물에 대한 결합 부위를 제공할 수 있다. 선택가능 마커의 예는 비제한적으로 하기를 포함한다: (1) 다른 독성 화합물(예를 들어, 항생제)에 대해 내성을 제공하는 생성물을 인코딩하는 DNA 분절; (2) 수령체 세포에서 달리 결여되어 있는 생성물(예를 들어, tRNA 유전자, 영양요구성 마커)을 인코딩하는 DNA 분절; (3) 유전자 생성물의 활성을 억제하는 생성물을 인코딩하는 DNA 분절; (4) 용이하게 식별될 수 있는 생성물(예를 들어, 표현형 마커, 예컨대 베타-갈락토시다제, 녹색 형광 단백질(GFP), 및 세포 표면 단백질)을 인코딩하는 DNA 분절; (5) 달리 세포 생존 및/또는 기능에 해로운 생성물에 결합하는 DNA 분절; (6) 상기 1-5에서 기술된 임의의 DNA 분절의 활성을 달리 억제하는 DNA 분절(예를 들어, 안티센스 올리고뉴클레오티드); (7) 기질(예를 들어, 제한 엔도뉴클레아제)을 변형시키는 생성물에 결합하는 DNA 분절; (8) 원하는 분자(예를 들어, 특이적 단백질 결합 부위)를 분리하는데 사용될 수 있는 DNA 분절; (9) (예를 들어, 분자의 하위집단의 PCR 증폭에 있어서) 달리 비-기능성일 수 있는 특이적 뉴클레오티드 서열을 인코딩하는 DNA 분절; 및/또는 (10) 부재하는 경우 특정 화합물에 대한 민감성을 직접적으로 또는 간접적으로 부여하는 DNA 분절.
서열 동일성은 디폴트 갭 파라미터를 사용하는 Wisconsin Genetics Software Package Release 7.0, Genetics Computer Group, 575 Science Dr., Madison, Wis.)에서 BESTFIT, FASTA 및 TFASTA와 같은 알고리즘을 사용하여 서열을 정렬함으로써, 또는 검사 및 최상의 정렬(즉, 비교 창에서 가장 높은 백분율의 서열 유사성을 발생시킴)에 의해 결정될 수 있다. 서열 동일성의 백분율은 비교 창에 걸쳐 두 개의 최적으로 정렬된 서열을 비교하고, 일치된 위치의 수를 산출하기 위해 동일한 잔기가 두 서열 모두에서 발생하는 위치의 수를 결정하고, 비교 창(즉, 창 크기)의 갭을 계산하지 않고 일치하는 위치와 일치하지 않는 위치의 총 수로 일치된 위치의 수를 나누고, 결과에 100을 곱하여 서열 동일성의 백분율을 산출함으로써 계산된다. 달리 지시되지 않는 한, 두 서열 간의 비교 창은 두 서열 중 더 짧은 서열의 전체 길이로 정의된다.
"표적 핵산"은 트랜스포존이 삽입되는 핵산이다. 이러한 표적은 염색체, 에피솜 또는 벡터의 일부일 수 있다.
트랜스포사제에 대한 "통합 표적 서열" 또는 "표적 서열" 또는 "표적 부위"는 트랜스포존이 트랜스포사제에 의해 삽입될 수 있는 표적 DNA 분자의 부위 또는 서열이다. 트리코플뤼시아니로부터의 피기백 트랜스포사제는 이의 트랜스포존을 주로 표적 서열 5'-TTAA-3'에 삽입시킨다. 피기백 트랜스포존에 대한 다른 유용한 표적 서열은 5'-CTAA-3', 5'-TTAG-3', 5'-ATAA-3', 5'-TCAA-3', 5'-AGTT-3', 5'-ATTA-3', 5'-GTTA-3', 5'-TTGA-3', 5'-TTTA-3', 5'-TTAC-3', 5'-ACTA-3', 5'-AGGG-3', 5'-CTAG-3', 5'-GTAA-3', 5'-AGGT-3', 5'-ATCA-3', , 5'- CTCC-3', 5'- TAAA-3', 5'-TCTC-3', 5'-TGAA-3', 5'-AAAT-3', 5'-AATC-3', 5'-ACAA-3', 5'-ACAT-3', 5'-ACTC-3', 5'-AGTG-3', 5'-ATAG-3', 5'-CAAA-3', 5'-CACA-3', 5'-CATA-3', 5'-CCAG-3', 5'-CCCA-3', 5'-CGTA-3', 5'-CTGA-3', 5'-GTCC-3', 5'-TAAG-3', 5'-TCTA-3', 5'-TGAG-3', 5'-TGTT-3', 5'-TTCA-3', 5'-TTCT-3' 및 5'-TTTT-3'이다 (Li et al., 2013. Proc. Natl. Acad. Sci vol. 110, no. 6, E478-487). 피기백-유사 트랜스포사제는 컷-앤-페이스트 메커니즘을 사용하여 이들의 트랜스포존을 전위시키며, 이는 DNA 분자에 삽입할 때 4개 염기쌍 표적 서열의 복제를 발생시킨다. 따라서, 표적 서열은 통합된 피기백-유사 트랜스포존의 각각의 측면에서 발견된다.
용어 "번역"은 폴리펩티드가 폴리뉴클레오티드의 서열을 '판독'하는 리보솜에 의해 합성되는 과정을 지칭한다.
'트랜스포사제'는 도너 폴리뉴클레오티드, 예를 들어 벡터로부터 상응하는 트랜스포존의 절제, 및 (단 트랜스포사제가 통합-결핍이 아닌 경우) 트랜스포존의 표적 핵산으로의 후속 통합을 촉매하는 폴리펩티드이다. "아마이엘로이스 트랜스포사제"는 상응하는 트랜스포존을 전위시킬 수 있는 SEQ ID NO: 18의 과활성 변이체를 포함하는, SEQ ID NO: 18에 대해 적어도 80%, 90, 95, 96, 97, 98, 99 또는 100% 서열 동일성을 갖는 트랜스포사제를 의미한다. 과활성 트랜스포사제는 절제 활성 또는 전위 활성 또는 이 둘 모두에 대해 유래된 자연 발생 트랜스포사제보다 더욱 활성인 트랜스포사제이다. 과활성 트랜스포사제는 유래하는 자연 발생 트랜스포사제보다 바람직하게는, 적어도 1.5배 더 활성, 또는 적어도 2배 더 활성, 또는 적어도 5배 더 활성, 또는 적어도 10배 더 활성이며, 예를 들어, 2-5배 또는 2-10배 더 활성이다. 트랜스포사제는 하나 이상의 추가 도메인, 예컨대 핵 국소화 서열 또는 DNA 결합 단백질에 융합되거나 융합되지 않을 수 있다.
용어 "전위"는 본원에서 하나의 폴리뉴클레오티드로부터 트랜스포존을 절제한 후 이를 동일한 폴리뉴클레오티드의 상이한 부위 또는 제2 폴리뉴클레오티드 내에 통합시키는데 있어서 트랜스포사제의 작용을 의미하는데 사용된다.
용어 "트랜스포존"은 상응하는 트랜스-작용 트랜스포사제의 작용에 의해 제1 폴리뉴클레오티드, 예를 들어 벡터로부터 절제될 수 있고, 동일한 폴리뉴클레오티드의 제2 위치로 또는 제2 폴리뉴클레오티드, 예를 들어 세포의 게놈 또는 염색체외 DNA에 통합될 수 있는 폴리뉴클레오티드를 의미한다. 트랜스포존은 제1 트랜스포존 말단 및 제2 트랜스포존 말단을 포함하며, 이들은 트랜스포사제에 의해 인식되고 전위되는 폴리뉴클레오티드 서열이다. 트랜스포존은 일반적으로 2개의 트랜스포존 말단 사이에 제1 폴리뉴클레오티드 서열을 추가로 포함하여, 제1 폴리뉴클레오티드 서열이 트랜스포사제의 작용에 의해 2개의 트랜스포존 말단과 함께 전위된다. 천연 트랜스포존의 이러한 제1 폴리뉴클레오티드는 빈번하게 트랜스포존을 인식하고 전위하는 상응하는 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 포함한다. 본 발명의 트랜스포존은 2개의 트랜스포존 말단 사이의 병치로 인해 전위될 수 있는 이종성 폴리뉴클레오티드 서열을 포함하는 "합성 트랜스포존"이다. 합성 트랜스포존은 트랜스포존 말단 외측에 측접하는 폴리뉴클레오티드 서열(들), 예컨대 트랜스포사제를 인코딩하는 서열, 벡터 서열 또는 선택가능 마커를 인코딩하는 서열을 추가로 포함하거나 포함하지 않을 수 있다.
용어 "트랜스포존 말단"은 상응하는 트랜스포사제에 의한 인식 및 전위에 충분한 시스-작용 뉴클레오티드 서열을 의미한다. 피기백-유사 트랜스포존의 트랜스포존 말단은 완전 또는 불완전한 반복부를 포함하여 2개의 트랜스포존 말단의 각각의 반본부는 서로에 대해 역 상보성이다. 이들은 역방위 말단 반복(ITR) 또는 말단 역방위 반복(TIR)으로서 지칭된다. 트랜스포존 말단은 전위를 촉진하거나 증대시키는 ITR에 근접한 추가 서열을 포함하거나 포함하지 않을 수 있다.
용어 "벡터" 또는 "DNA 벡터" 또는 "유전자 전달 벡터"는 또 다른 폴리뉴클레오티드에 대한 "운반" 기능을 수행하는데 사용되는 폴리뉴클레오티드를 지칭한다. 예를 들어, 벡터는 폴리뉴클레오티드가 살아있는 세포 내에서 증식되게 하거나, 폴리뉴클레오티드가 세포 내로의 전달을 위해 포장되게 하거나, 폴리뉴클레오티드가 세포의 게놈 DNA에 통합되게 하는데 종종 사용된다. 벡터는 추가 기능 요소를 추가로 포함할 수 있으며, 예를 들어 이는 트랜스포존을 포함할 수 있다.
5.2 설명
5.2.1 게놈 통합
진핵 숙주 세포에서 이종성 폴리뉴클레오티드로부터의 유전자 발현은 이종성 폴리뉴클레오티드가 숙주 세포의 게놈 내로 통합되는 경우 향상될 수 있다. 숙주 세포의 게놈 내로의 폴리뉴클레오티드의 통합은 또한, 게놈 DNA의 복제 및 분열을 보장하는 동일한 메카니즘으로 이를 처리함으로써 일반적으로 안정적으로 유전될 수 있게 한다. 이러한 안정적인 유전성은 긴 성장 기간에 걸쳐 우수하고 일관된 발현을 달성하는데 바람직하다. 이는 세포가 유전자 변형된 후 체내에 삽입되는 세포 요법에 특히 중요하다. 또한, 생체분자의 제조, 특히 숙주의 안정성 및 발현 수준의 일관성이 조절 목적에 있어서 또한 중요한 치료 응용 분야에 중요하다. 따라서, 게놈에 통합된 트랜스포존-기반 유전자 전달 벡터를 포함하는 유전자 전달 벡터를 갖는 세포는 본 발명의 중요한 구체예이다.
이종성 폴리뉴클레오티드는 이들이 트랜스포존의 일부인 경우 (즉, 트랜스포존 ITR 사이에 위치하는 경우) 표적 게놈 내로 더욱 효율적으로 통합될 수 있으며, 예를 들어 이들은 트랜스포사제에 의해 통합될 수 있다. 트랜스포존의 특정 이점은, 트랜스포존 ITR 사이의 전체 폴리뉴클레오티드가 통합된다는 점이다. 이종성 폴리뉴클레오티드에 측접되는 ITR에 측접되는 표적 부위를 포함하는 트랜스포존은 게놈의 표적 부위에 통합되어 표적 부위에 측접되는 ITR에 측접되는 이종성 폴리뉴클레오티드를 함유하는 게놈을 발생시킨다. 이는 진핵 세포에 도입된 폴리뉴클레오티드가 종종 세포에서 무작위로 단편화되고, 폴리뉴클레오티드의 단지 일부만이 일반적으로 낮은 빈도로 표적 게놈 내로 통합되는 무작위 통합과 대조적이다. 로퍼 나방 트리코플뤼시아니로부터의 피기백 트랜스포존은 많은 유기체로부터의 세포에서 이의 트랜스포사제에 의해 전위되는 것으로 입증되었다(예를 들어, 문헌 [Keith et al (2008) BMC Molecular Biology 9:72 "Analysis of the piggyBac transposase reveals a functional nuclear targeting signal in the 94 c-terminal residues"] 참조). 피기백-유사 트랜스포존 내로 통합된 이종성 폴리뉴클레오티드는 동물 세포, 진균 세포 또는 식물 세포를 포함하는 진핵 세포 내로 통합될 수 있다. 바람직한 동물 세포는 척추동물 또는 무척추동물일 수 있다. 바람직한 척추동물 세포는 설치류, 예컨대 래트, 마우스 및 햄스터; 유제류, 예컨대 소, 염소 또는 양; 및 돼지를 포함하는 포유동물로부터의 세포를 포함한다. 바람직한 척추동물 세포는 또한 인간 조직으로부터의 세포 및 인간 줄기 세포를 포함한다. 표적 세포 유형은 간세포, 신경 세포, 근육 세포, 혈액 세포, 배아 줄기 세포, 체세포 줄기 세포, 조혈 세포, 배아, 접합자, 정자 세포(이의 일부는 시험관 내 설정에서 조작되기 위해 개방됨) 및 림프구, 예컨대 T 세포, B 세포 및 자연 살해 세포, T-헬퍼 세포, 항원-제시 세포, 수지상 세포, 호중구 및 대식세포를 포함하는 면역 세포를 포함한다. 바람직한 세포는 다능성 세포(자손이 조혈 줄기 세포 또는 다른 줄기 세포와 같은 여러 제한된 세포 유형으로 분화할 수 있는 세포) 또는 전능성 세포(즉, 자손이 유기체의 임의의 세포 유형이 될 수 있는 세포, 예를 들어 배아 줄기 세포)일 수 있다. 바람직한 배양 세포는 차이니즈 햄스터 난소(CHO) 세포 또는 인간 배아 신장(HEK293) 세포이다. 바람직한 진균 세포는 사카로마이세스 세레비시애 및 피치아 파스토리스를 포함하는 효모 세포이다. 바람직한 식물 세포는 조류(alage), 예를 들어 클로렐라, 타바코, 옥수수 및 벼이다(Nishizawa-Yokoi et al (2014) Plant J. 77:454-63 "Precise marker excision system using an animal derived piggyBac transposon in plants").
바람직한 유전자 전달 시스템은 트랜스포존을 전위하는 상응하는 트랜스포사제 단백질, 또는 상응하는 트랜스포사제 단백질을 인코딩하며 표적 세포에서 발현가능한 트랜스포사존을 핵산과 함께 포함한다. 바람직한 유전자 전달 시스템은 합성 아마이엘로이스 트랜스포존 및 상응하는 아마이엘로이스 트랜스포사제를 포함한다.
트랜스포사제 단백질은 단백질로서 또는 트랜스포사제를 인코딩하는 핵산으로서, 예를 들어, mRNA 또는 세포의 번역 기구에 의해 인식되는 임의의 폴리뉴클레오티드를 포함하는 리보핵산으로서; DNA로서, 예를 들어 에피솜 DNA를 포함하는 염색체외 DNA로서; 플라스미드 DNA로서 또는 바이러스 핵산으로서 세포 내에 도입될 수 있다. 또한, 트랜스포사제 단백질을 인코딩하는 핵산은 핵산 벡터로서, 예컨대 플라스미드로서 또는 바이러스 벡터를 포함하는 유전자 발현 벡터로서 세포 내로 형질감염될 수 있다. 핵산은 원형 또는 선형일 수 있다. 트랜스포사제를 인코딩하는 mRNA는 트랜스포사제를 인코딩하는 유전자가 시험관내에서 활성인 박테리아 T7 프로모터와 같은 이종성 프로모터에 작동가능하게 연결된 DNA를 사용하여 제조될 수 있다. 트랜스포사제 단백질을 인코딩하는 DNA는 구성적 또는 유도성 발현을 위해 세포의 게놈 내에 또는 벡터 내에 안정적으로 삽입될 수 있다. 트랜스포사제 단백질이 세포 내로 형질감염되거나 DNA로서 벡터 내에 삽입되는 경우, 트랜스포사제 인코딩 서열은 바람직하게는 이종성 프로모터에 작동가능하게 연결된다. 구성적 프로모터, 세포-유형 특이적 프로모터, 유기체-특이적 프로모터, 조직-특이적 프로모터, 유도성 프로모터, 기타 등등을 포함하는 사용될 수 있는 다양한 프로모터가 있다. 트랜스포사제를 인코딩하는 DNA가 프로모터에 작동가능하게 연결되고, 표적 세포 내로 형질감염되는 경우, 프로모터는 표적 세포에서 작동 가능해야 한다. 예를 들어, 표적 세포가 포유동물 세포인 경우, 프로모터는 포유동물 세포에서 작동가능해야 하고; 표적 세포가 효모 세포인 경우, 프로모터는 효모 세포에서 작동 가능해야 하고; 표적 세포가 곤충 세포인 경우, 프로모터는 곤충 세포에서 작동 가능해야 하고; 표적 세포가 인간 세포인 경우, 프로모터는 인간 세포에서 작동 가능해야 하고; 표적 세포가 인간 면역 세포인 경우, 프로모터는 인간 면역 세포에서 작동 가능해야 한다. 피기백-유사 트랜스포사제 단백질을 인코딩하는 모든 DNA 또는 RNA 서열이 명시적으로 고려된다. 대안적으로, 트랜스포사제는 예를 들어, 세포-침투 펩티드(예를 들어, 문헌 [Ramsey and Flynn (2015) Pharmacol. Ther. 154: 78-86 "Cell-penetrating peptides transport therapeutics into cells"]에 기술된 바와 같음)를 사용하여; 염 플러스 프로판베타인을 포함하는 소분자를 사용하여(예를 들어, 문헌 [Astolfo et al (2015) Cell 161: 674-690]에 기술된 바와 같음); 또는 전기천공을 사용하여(예를 들어, 문헌 [Morgan and Day (1995) Methods in Molecular Biology 48: 63-71 "The introduction of proteins into mammalian cells by electroporation"]에 기술된 바와 같음) 단백질로서 세포 내에 직접적으로 도입될 수 있다.
다양한 재현가능한 메카니즘을 통한 비-상동성 재조합에 의해 심지어 트랜스포사제의 활성 없이도 세포의 DNA 내로 트랜스포존을 삽입하는 것이 가능하다. 본원에 기술된 트랜스포존은 유전자가 전달되는 메카니즘과 무관하게 유전자 전달에 사용될 수 있다.
5.2.5 유전자 전달 시스템
유전자 전달 시스템은 숙주 세포에 전달될 폴리뉴클레오티드를 포함한다. 바람직하게는, 폴리뉴클레오티드는 아마이엘로이스 트랜스포존을 포함하며, 여기에서 폴리뉴클레오티드는 표적 세포의 게놈 내로 통합되어야 한다.
유전자 전달 시스템의 다중 구성요소, 예를 들어, 표적 세포에서 발현을 위한 유전자를 포함하고, 임의적으로 트랜스포존 말단을 포함하는 하나 이상의 폴리뉴클레오티드, 및 트랜스포사제(이는 단백질로서 제공될 수 있거나 핵산에 의해 인코딩될 수 있음)가 있는 경우, 이러한 구성요소는 동시에 또는 순차적으로 세포내로 형질감염될 수 있다. 예를 들어, 트랜스포사제 단백질 또는 이의 엔코딩 핵산은 상응하는 트랜스포존의 형질감염 전에, 이와 동시에 또는 후에 세포 내로 형질감염될 수 있다. 또한, 유전자 전달 시스템의 어느 한 구성요소의 투여는 예를 들어, 이 구성요소의 적어도 2회 용량을 투여함으로써 반복적으로 발생할 수 있다.
본원에 기술된 임의의 트랜스포사제 단백질은 RNA 또는 DNA를 포함하는 폴리뉴클레오티드에 의해 인코딩될 수 있다. 유사하게, 본 발명의 트랜스포사제 단백질 또는 트랜스포존을 인코딩하는 핵산은 플라스미드 또는 재조합 바이러스 DNA로서 선형 단편 또는 원형 단편으로서 세포 내로 형질감염될 수 있다.
아마이엘로이스 트랜스포사제는 표적 세포에서 발현가능한 DNA 분자로 제공될 수 있다. 아마이엘로이스 트랜스포사제를 인코딩하는 서열은 표적 세포에서 트랜스포사제의 발현을 가능하게 하는 이종성 서열에 작동가능하게 연결되어야 한다. 아마이엘로이스 트랜스포사제를 인코딩하는 서열은 표적 세포에서 활성인 이종성 프로모터에 작동가능하게 연결될 수 있다. 예를 들어, 표적 세포가 포유동물 세포인 경우, 프로모터는 포유동물 세포에서 활성이어야 한다. 표적이 척추동물 세포인 경우, 프로모터는 척추동물 세포에서 활성이어야 한다. 표적 세포가 식물 세포인 경우, 프로모터는 식물 세포에서 활성이어야 한다. 프로모터가 곤충 세포인 경우, 프로모터는 곤충 세포에서 활성이어야 한다. 아마이엘로이스 트랜스포사제를 인코딩하는 서열은 또한 표적 세포에서 발현에 필요한 다른 서열 요소, 예를 들어 폴리아데닐화 서열, 터미네이터 서열 등에 작동가능하게 연결될 수 있다.
아마이엘로이스 트랜스포사제는 표적 세포에서 발현 가능한 mRNA로서 제공될 수 있다. mRNA는 바람직하게는 시험관내 전사 반응에서 제조된다. 시험관내 전사의 경우, 아마이엘로이스 트랜스포사제를 인코딩하는 서열은 시험관내 전사 반응에서 활성인 프로모터에 작동가능하게 연결된다. 시험관내 전사 반응에서 활성인 예시적인 프로모터는 T7 RNA 중합효소에 의한 전사를 가능하게 하는 T7 프로모터(5'-TAATACGACTCACTATAG-3'), T3 RNA 중합효소에 의한 전사를 가능하게 하는 T3 프로모터(5'-AATTAACCCTCACTAAAG-3') 및 SP6 RNA 중합효소에 의한 전사를 가능하게 하는 SP6 프로모터(5'-ATTTAGGTGACACTATAG-3')를 포함한다. 시험관내 전사에 사용될 수 있는 이들 프로모터 및 기타 프로모터의 변이체는 또한 아마이엘로이스 트랜스포사제를 인코딩하는 서열에 작동가능하게 연결될 수 있다.
아마이엘로이스 트랜스포사제가 트랜스포사제를 인코딩하는 폴리뉴클레오티드(DNA 또는 mRNA)로서 제공되는 경우, 표적 세포에서 트랜스포사제의 발현성을 향상시키는 것이 유리한다. 따라서, 트랜스포사제를 인코딩하기 위해 자연 발생 서열 이외의 서열을 사용하는 것이, 즉 발현이 수행될 세포 유형의 코돈-선호도를 이용하는 것이 유리하다. 예를 들어, 표적 세포가 포유동물 세포인 경우, 코돈은 포유동물 세포에서 보이는 선호도 쪽으로 편향되어야 한다. 표적이 척추동물 세포인 경우, 코돈은 특정 척추동물 세포에서 보이는 선호도 쪽으로 편향되어야 한다. 표적 세포가 식물 세포인 경우, 코돈은 식물 세포에서 보이는 선호도 쪽으로 편향되어야 한다. 프로모터가 곤충 세포인 경우, 코돈은 곤충 세포에서 보이는 선호도 쪽으로 편향되어야 한다.
바람직한 RNA 분자는 진핵 세포에서 번역을 향상시키기 위한 적절한 캡 구조, 폴리아데닐산 및 진핵 세포에서 mRNA 안정성을 향상시키는 기타 3' 서열 및 임의적으로 세포에 대한 독성 효과를 감소시키기 위한 치환, 예를 들어 슈도우리딘으로의 우리딘의 치환 및 시토신의 5-메틸 시토신으로의 치환을 갖는 것들을 포함한다. 아마이엘로이스 트랜스포사제를 인코딩하는 mRNA는 표적 세포에서의 발현을 향상시키기 위해 5'-캡 구조를 갖도록 제조될 수 있다. 예시적인 캡 구조는 캡 유사체(G(5')ppp(5')G), 항-역방향 캡 유사체(3'-O-Me-m7G(5')ppp(5')G, 깨끗한 캡(m7G(5')ppp(5')(2'OMeA)pG), mCap(m7G(5')ppp(5')G)이다. 아마이엘로이스 트랜스포사제를 인코딩하는 mRNA는 일부 염기가 부분적으로 또는 완전히 치환되도록 제조될 수 있으며, 예를 들어 우리딘은 슈도-우리딘으로 치환될 수 있고, 시토신은 5-메틸-시토신으로 치환될 수 있다. 이들 캡과 치환의 임의의 조합이 만들어질 수 있다.
유전자 전달 시스템의 구성요소는 입자 충격, 전기천공, 미세주입, 구성요소와 지질-함유 소포, 예컨대 양이온성 지질 소포, DNA 응축 시약(예를 들어, 인산칼슘, 폴리리신 또는 폴리에틸렌이민)의 조합, 및 구성요소(즉, 이의 핵산)의 바이러스 벡터 내로의 삽입 및 바이러스 벡터와 세포의 접촉과 같은 기술에 의해 하나 이상의 세포 내로 형질감염될 수 있다. 바이러스 벡터가 사용되는 경우, 바이러스 벡터는 레트로바이러스 벡터, 아데노바이러스 벡터 또는 아데노-연관 바이러스 벡터로 구성된 군으로부터 선택되는 바이러스 벡터를 포함하는 당업계에 공지된 다양한 바이러스 벡터 중 임의의 것을 포함할 수 있다. 유전자 전달 시스템은 당업계에 공지된 적절한 방식으로, 또는 약학적 조성물 또는 키트로서 포뮬레이션될 수 있다.
5.2.3 유전자 전달 시스템의 서열 구성요소
숙주 세포 게놈 내로 통합된, 아마이엘로이스 트랜스포존을 포함하는 피기백-유사 트랜스포존과 같은 유전자 전달 폴리뉴클레오티드로부터의 유전자의 발현은 종종 통합되는 염색질 환경에 의해 크게 영향을 받는다. 진정염색질 내에 통합된 폴리뉴클레오티드는 이질염색질 내로 통합되거나 통합 후 침묵하게 되는 폴리뉴클레오티드보다 더 높은 수준의 발현을 갖는다. 이종성 폴리뉴클레오티드의 침묵은 염색질 조절 요소를 포함하는 경우 감소될 수 있다. 따라서, 유전자 전달 폴리뉴클레오티드(본원에 기술된 임의의 트랜스포존 포함)가 이질염색질(격리자)의 확산을 방지하는 서열과 같은 염색질 조절 요소를 포함하는 것이 유리하다. 아마이엘로이스 트랜스포존을 포함하는 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 435-441 중 하나로부터 선택된 서열과 적어도 95% 동일한 격리자 서열을 포함하고, 이들은 또한 통합된 유전자 전달 폴리뉴클레오티드로부터의 장기간의 안정한 발현을 증가시키기 위해 편재적으로 작용하는 염색질 개방 요소(UCOE) 또는 안정화 및 항-억제제 요소(STAR)를 포함할 수 있다. 유리한 유전자 전달 폴리뉴클레오티드는 매트릭스 부착 영역, 예를 들어, SEQ ID NO: 442-452로부터 선택되는 서열과 적어도 95% 동일한 서열을 추가로 포함할 수 있다.
일부 경우에, 유전자 전달 폴리뉴클레오티드는 트랜스포존 ITR 내에 발현될 서열(들)을 함유하는 이종성 폴리뉴클레오티드의 각 측면에 하나씩 2개의 격리자를 포함하는 것이 유리하다. 격리자는 동일할 수 있거나 이들은 상이할 수 있다. 특히 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 440 또는 SEQ ID NO: 441 중 하나로부터 선택된 서열과 적어도 95% 동일한 격리자 서열 및 SEQ ID NO: 435-439 중 하나로부터 선택된 서열과 적어도 95% 동일한 격리자 서열을 포함한다. 격리자는 또한 표현 조절 요소를 서로 보호한다. 예를 들어, 유전자 전달 폴리뉴클레오티드가 각각 다른 프로모터에 작동가능하게 연결된 두 개의 오픈 리딩 프레임을 인코딩하는 유전자를 포함하는 경우, 한 프로모터는 전사 간섭으로 알려진 현상에서 나머지 다른 하나의 프로모터로부터의 발현을 감소시킬 수 있다. 2개의 전사 단위체 사이에 SEQ ID NO: 435-441 중 하나로부터 선택된 서열과 적어도 95% 동일한 격리자 서열을 삽입하는 것은 이러한 간섭을 감소시킬 수 있어, 하나 또는 둘 모두의 프로모터로부터의 발현을 증가시킬 수 있다.
바람직한 유전자 전달 벡터는 높은 수준의 유전자 발현을 유도할 수 있는 발현 요소를 포함한다. 진핵 세포에서 유전자 발현은 인핸서, 프로모터, 인트론, RNA 이출 요소, 폴리아데닐화 서열 및 전사 종결인자를 포함하는 여러 다른 부류의 요소에 의해 조절된다.
진핵 세포로의 발현을 위한 유전자 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 유전자에 작동가능하게 연결된 인핸서를 포함한다. 포유동물 세포로의 발현을 위한 유전자의 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 유전자에 작동가능하게 연결된, 인간, 영장류 또는 설치류 세포로부터의 사이토메갈로바이러스(CMV)의 전초기 유전자 1, 2 또는 3으로부터의 인핸서(예를 들어, SEQ ID NO: 453-471 중 임의의 것과 적어도 95% 동일한 서열), 아데노바이러스 주요 후기 단백질 인핸서로부터의 인핸서(예를 들어, SEQ ID NOS: 472와 적어도 95% 동일한 서열) 또는 SV40로부터의 인핸서(예를 들어, SEQ ID NO: 473과 적어도 95% 동일한 서열)을 포함한다.
진핵 세포로의 발현을 위한 유전자 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 유전자에 작동가능하게 연결된 프로모터를 포함한다. 포유동물 세포로의 발현을 위한 유전자 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 유전자에 작동가능하게 연결된, 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 EF1a 프로모터(예를 들어, SEQ ID NO: 474-495 중 임의의 것); 인간, 영장류 또는 설치류 세포로부터의 사이토메갈로바이러스(CMV)의 전초기 유전자 1, 2 또는 3으로부터의 프로모터(예를 들어, SEQ ID NO: 496-506 중 임의의 것); 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 진핵생물 신장 인자 2(EEF2)에 대한 프로모터(예를 들어, SEQ ID NO: 507-517 중 임의의 것); 임의의 포유동물 또는 효모 종으로부터의 GAPDH 프로모터(예를 들어, SEQ ID NO: 528-544 중 임의의 것), 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 액틴 프로모터(예를 들어, SEQ ID NO: 518-527 중 임의의 것); 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 PGK 프로모터(예를 들어, SEQ ID NO: 545-551 중 임의의 것), 또는 유비퀴틴 프로모터(예를 들어, SEQ ID NO: 552)를 포함한다. 프로모터는 i) 이종성 오픈 리딩 프레임; ii) 선택가능 마커를 인코딩하는 핵산; iii) 카운터-선택가능 마커를 인코딩하는 핵산; iv) 조절 단백질을 인코딩하는 핵산; v) 억제성 RNA를 인코딩하는 핵산에 작동가능하게 연결될 수 있다.
진핵 세포로의 발현을 위한 유전자의 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 표적 세포에서 스플라이싱 가능한 이종성 폴리뉴클레오티드 내의 인트론을 포함한다. 포유동물 세포로의 발현을 위한 유전자의 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 폴리뉴클레오티드 내의, 인간, 영장류 또는 설치류 세포로부터의 사이토메갈로바이러스(CMV)의 전초기 유전자 1, 2 또는 3으로부터의 인트론(예를 들어, SEQ ID NO: 561-571 중 임의의 것과 적어도 95% 동일한 서열), 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 EF1a로부터의 인트론(예를 들어, SEQ ID NO: 581-593 중 임의의 것과 적어도 95% 동일한 서열), 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 EEF2로부터의 인트론(예를 들어, SEQ ID NO: 613-620 중 임의의 것과 적어도 95% 동일한 서열); 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종의 액틴으로부터의 인트론(예를 들어, SEQ ID NO: 594-607 중 임의의 것과 적어도 95% 동일한 서열), 인간, 래트, 마우스, 닭 및 차이니즈 햄스터를 포함하는 임의의 포유동물 또는 조류 종으로부터의 GAPDH 인트론(예를 들어, SEQ ID NO: 608-610 중 임의의 것과 적어도 95% 동일한 서열); 아데노바이러스 주요 후기 단백질 인핸서를 포함하는 인트론(예를 들어, SEQ ID NO: 611-612와 적어도 95% 동일한 서열) 또는 하이브리드/합성 인트론(예를 들어, SEQ ID NO: 572-580 중 임의의 것과 적어도 95% 동일한 서열)을 포함한다.
진핵 세포로의 발현을 위한 유전자 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 이종성 코딩 서열에 작동가능하게 연결된 인핸서 및 프로모터를 포함한다. 이러한 유전자 전달 폴리뉴클레오티드는 인핸서 및 프로모터의 조합을 포함할 수 있으며, 여기서 하나의 유전자로부터의 인핸서는 상이한 유전자로부터의 프로모터와 조합되며, 즉 인핸서는 프로모터에 이종성이다. 예를 들어, 발현을 위한 유전자의 포유동물 세포 내로의 전달에 있어서, 설치류 또는 인간 또는 영장류로부터의 전초기 CMV 인핸서(예컨대, SEQ ID NO: 453-471로부터 선택된 서열)에 이어서 유리하게는, 이종성 서열에 작동가능하게 연결된, EF1a 유전자로부터의 프로모터(예컨대, SEQ ID NO: 474-495로부터 선택된 서열), 또는 이종성 CMV 유전자로부터의 프로모터(예컨대, SEQ ID NO: 496-506으로부터 선택된 서열), 또는 EEF2 유전자로부터의 프로모터(예컨대, SEQ ID NO: 507-517로부터 선택된 서열), 또는 액틴 유전자로부터의 프로모터(예컨대, SEQ ID NO: 518-527로부터 선택된 서열), 또는 GAPDH 유전자로부터의 프로모터(예컨대, SEQ ID NO: 528-544로부터 선택된 서열)가 뒤따른다.
진핵 세포로의 발현을 위한 유전자의 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 작동가능하게 연결된 프로모터 및 이종성 오픈 리딩 프레임에 작동가능하게 연결된 인트론을 포함한다. 이러한 유전자 전달 폴리뉴클레오티드는 프로모터 및 인트론의 조합을 포함할 수 있으며, 여기서 하나의 유전자로부터의 프로모터는 상이한 유전자로부터의 인트론과 조합되며, 즉 인트론은 프로모터에 이종성이다. 예를 들어, 발현을 위한 유전자를 포유동물 세포 내로 전달하는데 있어서, 설치류 또는 인간 또는 영장류로부터의 전초기 CMV 프로모터(예컨대, SEQ ID NO: 496-506으로부터 선택된 서열) 다음에, 이종성 서열에 작동가능하게 연결된, EF1a 유전자로부터의 인트론(예컨대, SEQ ID NO: 581-593으로부터 선택된 서열과 적어도 95% 동일한 서열) 또는 EEF2 유전자로부터의 인트론(예컨대, SEQ ID NO: 613-620으로부터 선택된 서열과 적어도 95% 동일한 서열), 또는 액틴 유전자로부터의 인트론(예를 들어, SEQ ID NO: 594-607로부터 선택된 서열과 적어도 95% 동일한 서열)이 뒤따른다.
진핵 세포로의 발현을 위한 유전자의 전달을 위한 유리한 유전자 전달 폴리뉴클레오티드는 인핸서 및/또는 인트론에 작동가능하게 연결된 프로모터를 포함하는 복합 전사 개시 조절 요소를 포함하고, 복합 전사 개시 조절 요소는 이종성 서열에 작동가능하게 연결되어 있다. 포유동물 세포로의 발현을 위한 유전자 전달을 위한 유전자 전달 폴리뉴클레오티드의 이종성 서열에 작동가능하게 연결될 수 있는 유리한 복합 전사 개시 조절 요소의 예는 SEQ ID NO: 622-714로부터 선택되는 서열이다.
단일 폴리뉴클레오티드로부터 2개의 오픈 리딩 프레임의 발현은 각각의 오픈 리딩 프레임의 발현을 별도의 프로모터에 작동가능하게 연결함으로써 달성될 수 있으며, 이들 프로모터 각각은 상기 기재된 바와 같이 인핸서 및 인트론에 작동가능하게 임의적으로 연결될 수 있다. 이는 항체의 사슬 또는 이중특이적 항체의 사슬, 또는 수용체 및 이의 리간드와 같은 특정 몰비로 상호작용할 필요가 있는 2개의 폴리펩티드를 발현하는 경우 특히 유용하다. 2개의 오픈 리딩 프레임 사이, 예를 들어, 제1 오픈 리딩 프레임에 작동가능하게 연결된 폴리아데닐화 서열의 3' 및 제2 폴리펩티드를 인코딩하는 제2 오픈 리딩 프레임에 작동가능하게 연결된 프로모터의 5'에 유전자 격리자를 배치시킴으로써 전사적 프로모터 간섭을 예방하는 것이 종종 유리하다. 전사 프로모터 간섭은 또한 제1 유전자의 전사를 효과적으로 종결시킴으로써 방지될 수 있다. 많은 진핵 세포에서, 2개의 오픈 리딩 프레임 사이의 강한 폴리A 신호 서열의 사용은 전사 촉진 간섭을 감소시킬 것이다. 전사를 효과적으로 종결시키는데 사용될 수 있는 폴리A 신호 서열의 예는 SEQ ID NO: 715-744로서 제공된다. 유리한 유전자 전달 폴리뉴클레오티드는 이종성 오픈 리딩 프레임에 작동가능하게 연결된 SEQ ID NO: 715-744로부터 선택된 서열과 적어도 95% 동일한 서열을 포함한다. 제1 유전자의 전사의 종료 및 제2 유전자의 전사의 개시를 위한 유리한 복합 조절 요소는 SEQ ID NO: 745-928로서 제공된 서열을 포함한다. 포유동물 세포로의 동시발현을 위한 제1 및 제2 오픈 리딩 프레임의 전달을 위한 특히 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 745-928로부터 선택된 서열과 적어도 90% 동일하거나 적어도 95% 동일하거나 적어도 99% 동일하거나 100% 동일한 서열을 포함하며, 이는 2개의 이종성 오픈 리딩 프레임을 분리한다.
5.2.4 유전자 전달 폴리뉴클레오티드를 포함하는 표적 세포의 선택
유전자 전달 폴리뉴클레오티드가 선택가능 마커를 인코딩하는 오픈 리딩 프레임을 포함하는 경우, 게놈이 안정적으로 통합된 전달 폴리뉴클레오티드를 포함하는 표적 세포가 선택가능 마커를 발현하는 세포에 유리한 조건("선택 조건")에 표적 세포를 노출시킴으로써 확인될 수 있다. 유전자 전달 폴리뉴클레오티드가 항생제, 예컨대 네오마이신(아미노글리코시드 3'-포스포트랜스퍼라제에 의해 부여된 내성, 예를 들어 SEQ ID NO: 262-265로부터 선택되는 서열), 푸로마이신(푸로마이신 아세틸트랜스퍼라제에 의해 부여된 내성, 예를 들어 SEQ ID NO: 268-270으로부터 선택되는 서열), 블라스티시딘(블라스티시딘 아세틸트랜스퍼라제 및 블라스티시딘 데아미나제에 의해 부여된 내성, 예를 들어 SEQ ID NO: 272), 하이그로마이신 B(하이그로마이신 B 포스포트랜스퍼라제에 의해 부여된 내성, 예를 들어 SEQ ID NO: 266-267로부터 선택된 서열) 및 제오신(ble 유전자에 의해 인코딩된 결합 단백질에 의해 부여된 내성, 예를 들어 SEQ ID NO: 259)에 대한 내성을 부여하는 효소와 같은 선택가능 마커를 인코딩하는 오픈 리딩 프레임을 포함하는 것이 유리하다. 다른 선택가능 마커는 형광성인 것들(예컨대, GFP, RFP 등을 인코딩하는 오픈 리딩 프레임)을 포함하며, 따라서 예를 들어, 유세포 분석을 사용하여 선택될 수 있다. 다른 선택가능 마커는 예를 들어, 유세포 분석기를 사용하여 막관통 단백질의 존재가 선택될 수 있도록 형광 라벨링될 수 있는 제2 분자(단백질 또는 소분자)에 결합할 수 있는 막관통 단백질을 인코딩하는 오픈 리딩 프레임을 포함한다.
유전자 전달 폴리뉴클레오티드는 글루타민 대사를 통한 선택을 가능하게 하는 글루타민 합성효소(GS, 예를 들어, SEQ ID NO: 274-278로부터 선택되는 서열)를 인코딩하는 선택가능 마커 오픈 리딩 프레임을 포함할 수 있으며, 이는 글루타민 대사를 통한 선택을 가능하게 한다. 글루타민 합성효소는 글루타메이트 및 암모니아로부터의 글루타민의 생합성을 담당하는 효소이며, 포유동물 세포에서 글루타민 형성을 위한 유일한 경로의 중요한 구성요소이다. 성장 배지 중 글루타민의 부재하에, GS 효소는 배양 중 포유동물 세포의 생존에 필수적이다. 일부 세포주, 예를 들어, 마우스 골수종 세포는 글루타민 첨가 없이 생존하기에 충분한 GS 효소를 발현하지 않는다. 이러한 세포에서, 형질감염된 GS 오픈 리딩 프레임은 글루타민-비함유 배지에서 성장을 허용함으로써 선택가능 마커로서 기능할 수 있다. 다른 세포주에서, 예를 들어, 차이니즈 햄스터 난소(CHO) 세포는 외인성으로 첨가된 글루타민의 부재하에 생존하기에 충분한 GS 효소를 발현한다. 이들 세포주는 GS 효소의 활성을 감소시키거나 제거하기 위해 CRISPR/Cas9를 포함하는 게놈 편집 기술에 의해 조작될 수 있다. 이 모든 경우에 메티오닌 설폭시민(MSX)과 같은 GS 억제제는 세포의 내인성 GS 활성을 억제하는데 사용될 수 있다. 선택 프로토콜은 제1 폴리펩티드 및 글루타민 합성효소 선택가능 마커를 인코딩하는 서열을 포함하는 유전자 전달 폴리뉴클레오티드를 도입한 다음, 세포를 메티오닌 설폭시민과 같은 글루타민 합성효소의 억제제로 처리하는 것을 포함한다. 사용되는 메티오닌 설폭시민의 수준이 높을수록, 세포가 생존하기에 충분한 글루타민을 합성할 수 있도록 하기 위해 글루타민 합성효소 발현 수준이 더 높아야 한다. 이들 세포 중 일부는 또한 제1 폴리펩티드의 증가된 발현을 나타낼 것이다.
바람직하게는, GS 오픈 리딩 프레임은 약한 프로모터 또는 본원에 기술된 바와 같이 발현을 약화시키는 다른 서열 요소에 작동가능하게 연결되어, 유전자 전달 폴리뉴클레오드의 많은 복사체가 존재하는 경우 또는 이들이 높은 수준의 발현이 발생하는 게놈의 위치에 통합되는 경우 높은 수준이 발현이 발생할 수 있다. 이러한 경우 억제제 메티오닌 설폭시민을 사용할 필요가 없을 수 있다: 글루타민 합성효소의 발현이 약화되는 경우, 세포 생존에 충분한 글루타민을 단순히 합성하는 것만으로 충분히 엄격한 선택을 제공할 수 있다.
유전자 전달 폴리뉴클레오티드는 5,6-디하이드로폴레이트(DHF)의 5,6,7,8-테트라하이드로폴레이트(THF)로의 환원을 촉매하는데 필요한 디하이드로폴레이트 환원효소(DHFR, 예를 들어 SEQ ID NO: 260-261로부터 선택된 서열)를 인코딩하는 선택가능 마커 오픈 리딩 프레임을 포함할 수 있다. 일부 세포주는 하이포잔틴과 티미딘(HT)을 첨가하지 않고 생존하기에 충분한 DHFR을 발현하지 않는다. 이러한 세포에서, 형질감염된 DHFR 오픈 리딩 프레임은 하이포잔틴 및 티미딘-비함유 배지에서 성장을 허용함으로써 선택가능 마커로서 기능할 수 있다. DHFR-결핍 세포주, 예를 들어 차이니즈 햄스터 난소(CHO) 세포는 내인성 DHRF 효소의 활성을 감소 또는 제거하기 위해 CRISPR/Cas9를 포함하는 게놈 편집 기술에 의해 생성될 수 있다. DHFR은 메토트렉세이트(MTX)에 대한 내성을 부여한다. DHFR은 더 높은 수준의 메토트렉세이트에 의해 억제될 수 있다. 선택 프로토콜은 기능적 내인성 DHFR 유전자가 있거나 없는 세포 내로 제1 폴리펩티드 및 DHFR 선택가능 마커를 인코딩하는 서열을 포함하는 작제물을 도입한 다음, 메토트렉세이트와 같은 DHFR의 억제제로 세포를 처리하는 것을 포함한다. 사용되는 메토트렉세이트의 수준이 높을수록, 세포가 생존하기에 충분한 DHFR을 합성할 수 있도록 하기 위해 더 높은 수준의 DHFR 발현이 필요하다. 이들 세포 중 일부는 또한 제1 폴리펩티드의 증가된 발현을 보여줄 것이다. 바람직하게는, DHFR 오픈 리딩 프레임은 약한 프로모터 또는 상기 기술된 바와 같이 발현을 약화시키는 다른 서열 요소에 작동가능하게 연결되어, 유전자 전달 폴리뉴클레오티드의 많은 복사체가 존재하는 경우 또는 이들이 높은 수준의 발현이 발생하는 게놈의 위치에 통합되는 경우 높은 수준이 발현이 발생할 수 있다.
높은 수준의 발현은 고도로 전사적으로 활성인 게놈의 영역에 통합되거나, 다중 복사체의 게놈에 통합되거나, 다중 복사체에 염색체외 존재하는 유전자 전달 폴리뉴클레오티드 상에 인코딩된 유전자로부터 수득될 수 있다. 유전자 전달 폴리뉴클레오티드로부터 선택가능 폴리펩티드의 낮은 수준의 발현을 발생시키는 발현 조절 요소에 대한 선택가능 마커를 인코딩하는 오픈 리딩 프레임을 작동가능하게 연결시키고/거나 보다 엄격한 선택을 제공하는 조건을 사용하는 것이 종종 유리하다. 이러한 조건 하에서, 발현 세포가 선택 조건에서 생존하기 위해 유전자 전달 폴리뉴클레오티드 상에 인코딩된 선택가능 폴리펩티드를 충분한 수준으로 생성하는데 있어서, 유전자 전달 폴리뉴클레오티드는 높은 수준의 발현을 위해 세포 게놈의 유리한 위치에 존재할 수 있거나 충분히 많은 수의 유전자 전달 폴리뉴클레오티드 복사체가 존재할 수 있어, 이들 인자가 발현 조절 요소로 인한 달성 가능한 낮은 수준의 발현을 보상할 수 있다.
선택가능 마커가 마커를 약하게만 발현하는 조절 요소에 작동가능하게 연결된 트랜스포존의 게놈 통합은 일반적으로 트랜스포사제에 의해 트랜스포존이 표적 게놈에 삽입되는 것을 필요로 한다(예를 들어, 섹션 6.1.3 참조). 약한 발현을 발생시키는 요소에 선택가능 마커를 작동가능하게 연결시킴으로써, 트랜스포존의 다중 복사체를 통합하거나 높은 발현에 유리한 게놈 위치에서 트랜스포존이 통합된 세포가 선택된다. 트랜스포존 및 상응하는 트랜스포사제를 포함하는 유전자 전달 시스템을 사용하면 트랜스포존의 다중 복사체를 갖는 세포가 생성될 것이거나 트랜스포존이 높은 발현에 유리한 게놈 위치에 통합되는 경향을 증가시킨다. 따라서, 트랜스포존 및 상응하는 트랜스포사제를 포함하는 유전자 전달 시스템은 트랜스포존이 약한 프로모터에 작동가능하게 연결된 선택가능 마커를 포함하는 경우 특히 유리하다.
RNA 또는 단백질로서 발현하고자 하는 핵산 및 선택가능 마커는 동일한 유전자 전달 폴리뉴클레오티드 상에 포함될 수 있지만, 다른 프로모터에 작동가능하게 연결될 수 있다. 이 경우 선택가능 마커의 낮은 발현 수준이 포스포글리세로키나제(PGK) 프로모터(예컨대, SEQ ID NO: 545-551로부터 선택된 프로모터), 단순 헤르페스 바이러스 티미딘 키나제(HSV-TK) 프로모터(예를 들어, SEQ ID NO: 553-554로부터 선택된 서열), MC1 프로모터(예를 들어, SEQ ID NO: 555), 유비퀴틴 프로모터(예를 들어, SEQ ID NO: 552로부터 선택된 서열)와 같은 약한 활성 구성적 프로모터를 사용하여 달성할 수 있다. 다른 약한 활성 프로모터, 예를 들어 절두에 의해 약화된 프로모터, 예를 들어 절두된 SV40 프로모터(예를 들어, SEQ ID NO: 556-557로부터 선택된 서열), 절두된 HSV-TK 프로모터(예를 들어, SEQ ID NO: 553), 또는 프로모터와 선택가능 폴리펩티드를 인코딩하는 오픈 리딩 프레임 사이에의 발현에 불리한 5'UTR 삽입에 의해 감쇠된 프로모터(예를 들어, SEQ ID NO: 559-560으로부터 선택된 서열)가 의도저으로 작제될 수 있다. 특히 유리한 유전자 전달 폴리뉴클레오티드는 선택가능 마커를 인코딩하는 오픈 리딩 프레임에 작동가능하게 연결된, SEQ ID NO: 545-558로부터 선택되는 프로모터 서열을 포함한다.
선택가능 마커의 발현 수준은 또한 선택가능 마커에 대한 오픈 리딩 프레임 뒤에 SV40 스몰 t 항원 인트론의 삽입과 같은 다른 메커니즘에 의해 유리하게 감소될 수 있다. SV40 스몰 t 인트론은 비정상적인 5' 스플라이스 부위를 수용하는데, 이는 스플라이싱된 mRNA의 분획에서 선행 오픈 리딩 프레임 내에서 결실을 일으켜, 이에 의해 선택가능 마커의 발현을 감소시킬 수 있다. 특히 유리한 유전자 전달 폴리뉴클레오티드는 선택가능 마커를 인코딩하는 오픈 리딩 프레임에 작동가능하게 연결된 인트론 SEQ ID NO: 621을 포함한다. 이러한 감쇠 메카니즘이 효과적이기 위해서는 선택가능 마커를 인코딩하는 오픈 리딩 프레임이 코딩 영역 내에 인트론 공여체를 포함하는 것이 바람직하다. DNA 서열 SEQ ID NO: 279-282는 각각 SEQ ID NO: 274-277을 갖는 글루타민 합성효소 서열을 인코딩하는 예시적인 핵산 서열이다. 이들 핵산 서열 각각은 인트론 공여체를 포함하며, 이는 글루타민 합성효소 오픈 리딩 프레임의 3'UTR 내에 인트론을 배치함으로써 SV40 스몰 t 항원 인트론에 작동가능하게 연결될 수 있다. 서열 SEQ ID NO: 271은 퓨로마이신 아세틸 트랜스퍼라제 SEQ ID NO: 270을 인코딩하는 예시적인 핵산 서열이며, 이는 인트론 공여체를 포함하고, 퓨로마이신 오픈 리딩 프레임의 3' UTR 내에 인트론을 배치함으로써 SV40 스몰 t 항원 인트론에 작동가능하게 연결될 수 있다. 유리한 유전자 전달 폴리뉴클레오티드는 SE ID NO: 621에 작동가능하게 연결된 SEQ ID NO: 279-282 또는 271 중 하나로부터 선택된 서열과 적어도 90% 동일하거나 적어도 95% 동일하거나 적어도 99% 동일하거나 100% 동일한 서열을 포함한다.
선택가능 마커의 발현 수준은 또한 전사체, 예를 들어 SEQ ID NO: 559-560 내의 억제성 5'-UTR의 삽입과 같은 다른 메커니즘에 의해 유리하게 감소될 수 있다. 특히 유리한 유전자 전달 폴리뉴클레오티드는 선택가능 마커를 인코딩하는 오픈 리딩 프레임에 작동가능하게 연결된 프로모터를 포함하며, 여기서 SEQ ID NO: 559-560과 적어도 90% 동일하거나 적어도 95% 동일하거나 적어도 99% 동일하거나 100% 동일한 서열이 프로모터와 선택가능 마커 사이에 삽입된다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 글루타민 합성효소 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 300-370 또는 432-434를 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 300-370 또는 432-434로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 글루타민 합성효소를 발현하며, 이에 의해 세포가 글루타민이 첨가되지 않은 상태 또는 MSX의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 글루타민 합성효소의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 300-370 또는 432-434로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 블라스티시딘-S-트랜스퍼라제 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 371-377을 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 371-377로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 블라스티시딘-S-트랜스퍼라제를 발현하며, 이에 의해 세포가 첨가된 블라스티시딘의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 블라스티시딘-S-트랜스퍼라제의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 371-377로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 하이그로마이신 B 포스포트랜스퍼라제 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 378-379를 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 378-379로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 하이그로마이신 B 포스포트랜스퍼라제를 발현하며, 이에 의해 세포가 첨가된 하이그로마이신의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 하이그로마이신 B 포스포트랜스퍼라제의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 378-379로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 아미노글리코시드 3'-포스포트랜스퍼라제 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 380-382 또는 408-409를 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 380-382 또는 408-409로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 아미노글리코시드 3'-포스포트랜스퍼라제를 발현하여 첨가된 네오마이신 존재하에서 세포가 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 아미노글리코시드 3'-포스포트랜스퍼라제의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 380-382 또는 408-409로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 퓨로마이신 아세틸트랜스퍼라제 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 383-402 또는 410-434를 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 383-402 또는 410-434로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 퓨로마이신 아세틸트랜스퍼라제를 발현하며, 이에 의해 세포가 첨가된 퓨로마이신의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 퓨로마이신 아세틸트랜스퍼라제의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 383-402 또는 410-434로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 ble 유전자 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 403-407를 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 403-407로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 ble 유전자를 발현하며, 이에 의해 세포가 첨가된 제오신의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 ble 유전자 생성물의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 403-407로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
포유동물 세포에서 발현가능한 조절 서열에 작동가능하게 연결된 디하이드로폴레이트 환원효소 코딩 서열을 포함하는 예시적인 핵산 서열은 SEQ ID NO: 283-299 또는 408-431을 포함한다. 표적 세포의 게놈 내로의 통합시 SEQ ID NO: 283-299 또는 408-431로부터 선택된 서열을 포함하는 유전자 전달 폴리뉴클레오티드는 디하이드로폴레이트 환원효소를 발현하며, 이에 의해 세포가 하이포크산틴 및 티미딘이 첨가되지 않은 상태 또는 MTX의 존재하에 성장하는 것을 돕는다. 이들 서열에서 조절 요소는 균형을 이루어 디하이드로폴레이트 환원효소의 낮은 수준의 발현을 생성하여, 게놈이 유전자 전달 폴리뉴클레오티드의 다중 복사체를 포함하는 표적 세포 또는 게놈이 인코딩된 유전자의 발현에 유리한 게놈의 영역에 유전자 전달 폴리뉴클레오티드의 복사체를 포함하는 표적 세포에 대한 선택적 이점을 제공한다. 유리한 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 283-299 또는 408-431로부터 선택된 서열을 포함하며, 이들은 좌측 트랜스포존 말단 및 우측 트랜스포존 말단을 추가로 포함할 수 있다.
약하게 발현된 선택가능 마커와 함께 트랜스포존 및 트랜스포사제의 사용은 트랜스포존 비함유 작제물에 비해 몇 가지 이점을 갖는다. 하나는 트랜스포존에 있어서 제1 폴리펩티드와 선택가능 마커의 발현 사이의 연결이 더 우수하다는 점인데, 트랜스포사제가 두 트랜스포존 말단 사이에 있는 전체 서열을 게놈 내로 통합시키기 때문이다. 대조적으로, 이종성 DNA가 진핵 세포, 예를 들어 포유동물 세포의 핵으로 도입될 경우, 이는 무작위 단편으로 분해되고, 이는 점차적으로 세포의 게놈에 통합되거나 분해될 수 있다. 따라서, 제1 폴리펩티드 및 선택가능 마커를 인코딩하는 서열을 포함하는 유전자 전달 폴리뉴클레오티드가 세포 집단에 도입되면, 일부 세포는 선택가능 마커를 인코딩하는 서열을 통합하지만, 제1 폴리펩티드를 인코딩하는 서열은 통합하지 않을 것이며, 그 반대의 경우도 있을 수 있다. 따라서, 높은 수준의 선택가능 마커를 발현하는 세포의 선택은 또한 높은 수준의 제1 폴리펩티드를 발현하는 세포와 단지 어느 정도만 상관관계가 있다. 대조적으로, 트랜스포사제는 트랜스포존 말단 사이의 서열 모두를 통합시키기 때문에, 높은 수준의 선택가능 마커를 발현하는 세포는 또한 높은 수준의 제1 폴리펩티드를 발현할 가능성이 높다.
트랜스포존과 트랜스포사제의 두 번째 이점은 DNA 서열을 게놈에 통합하는데 훨씬 더 효율적이라는 점이다. 따라서, 세포 집단의 훨씬 더 높은 분획이 유전자 전달 폴리뉴클레오티드의 하나 이상의 복사체를 이들의 게놈에 통합할 가능성이 있으며, 따라서, 선택가능 마커 및 제1 폴리펩티드 둘 모두를 양호하게 안정적으로 발현할 가능성이 상응하게 더 높을 것이다.
피기백-유사 트랜스포존 및 트랜스포사제의 세 번째 이점은 피기백-유사 트랜스포사제가 이의 상응하는 트랜스포존을 전사 활성 염색질에 삽입하는 쪽으로 편향되어 있다는 것이다. 따라서, 각각의 세포는 유전자 전달 폴리뉴클레오티드를 유전자가 잘 발현되는 게놈 영역 내로 통합할 가능성이 높으며, 따라서, 선택가능 마커 및 제1 폴리펩티드 둘 모두를 양호하게 안정적으로 발현할 가능성이 상응하게 더 높을 것이다.
5.2.5 신규한 피기백-유사 트랜스포사제
천연 DNA 트랜스포존은 트랜스포존이 제1 DNA 분자로부터 절제되어 제2 DNA 분자에 삽입되는 '컷 앤 페이스트' 복제 시스템을 거친다. DNA 트랜스포존은 역방위 말단 반복(ITR)을 특징으로 하며, 요소-인코딩된 트랜스포사제에 의해 동원된다. 피기백 트랜스포존/트랜스포사제 시스템은 트랜스포존이 통합되고 절제되는 정밀도로 인해 특히 유용하다(예를 들어, 문헌 ["Fraser, M. J. (2001) The TTAA-Specific Family of Transposable Elements: Identification, Functional Characterization, and Utility for Transformation of Insects. Insect Transgenesis: Methods and Applications. A. M. Handler and A. A. James. Boca Raton, Fla., CRC Press: 249-268"; and "US 20070204356 A1: PiggyBac constructs in vertebrates"] 및 여기의 나와 있는 참고문헌 참조).
트리코플뤼시아니로부터의 피기백 트랜스포사제와 유사한 서열을 갖는 많은 서열은 균류에서 포유류에 이르기까지 계통 발생학적으로 확실히 다른 종의 게놈에서 발견되었지만, 트랜스포사제 활성을 갖는 것으로 밝혀진 것은 매우 소수이다(예를 들어, 문헌 [Wu M, et al (2011) Genetica 139:149-54. "Cloning and characterization of piggyBac-like elements in lepidopteran insects"] 및 여기에 나와 있는 참고문헌 참조).
게놈 변형에 특히 이로운 트랜스포사제의 두 가지 특성은 폴리뉴클레오티드를 표적 게놈에 통합시키는 능력과 표적 게놈에서 폴리뉴클레오티드를 정확하게 절제하는 능력이다. 이러한 특성 둘 모두는 적합한 시스템으로 측정될 수 있다.
제1 폴리뉴클레오티드로부터의 트랜스포존의 절제인 제1 전위 단계를 측정하기 위한 시스템은 하기 구성요소를 포함한다: (i) 선택 숙주에서 발현되게 하는 서열에 작동가능하게 연결된 제1 선택가능 마커를 인코딩하는 제1 폴리뉴클레오티드 및 (ii) 트랜스포사제에 의해 인식되는 트랜스포존 말단을 포함하는 트랜스포존. 트랜스포존이 제1 선택가능 마커에 존재하여 제1 선택가능 마커의 코딩 서열을 중단시켜 제1 선택가능 마커가 활성화되지 않는다. 트랜스포존은 제1 트랜스포존의 정확한 절제가 제1 선택가능 마커를 재구성하도록 제1 선택가능 마커에 배치된다. 제1 트랜스포존을 절제할 수 있는 활성 트랜스포사제가 제1 폴리뉴클레오티드를 포함하는 숙주 세포 내에 도입되는 경우, 숙주 세포는 활성 제1 선택가능 마커를 발현할 것이다. 트랜스포존을 절제하는데 있어서 트랜스포사제의 활성은 제1 선택가능 마커 활성화를 필요로 하는 조건 하에서 숙주 세포가 성장할 수 있게 되는 빈도로서 측정될 수 있다.
트랜스포존이 선택 숙주에서 제2 선택가능 마커를 발현가능하게 하는 서열에 작동가능하게 연결된 제2 선택가능 마커를 포함하는 경우, 숙주 세포의 게놈 내로의 제2 선택가능 마커의 전위는 활성인 제1 및 제2 선택가능 마커를 포함하는 게놈을 생성할 것이다. 트랜스포존을 제2 게놈 위치로 전위시키는데 있어서 트랜스포사제의 활성은 제1 및 제2 선택가능 마커 활성화를 필요로 하는 조건 하에서 숙주 세포가 성장할 수 있게 되는 빈도로서 측정될 수 있다. 대조적으로, 제1 선택가능 마커가 존재하나, 제2 선택가능 마커가 존재하지 않는 경우, 이는 트랜스포존이 제1 폴리뉴클레오티드로부터 절제되나, 후속하여 제2 폴리뉴클레오티드 내로 전위되지 않았음을 나타낸다. 선택가능 마커는 예를 들어, 항생제 내성 단백질, 또는 영양요구성 마커 또는 임의의 다른 선택가능 마커를 인코딩하는 오픈 리딩 프레임일 수 있다.
섹션 6.1에 설명된 바와 같이 본 발명자들은 활성에 대해 추정되는 트랜스포사제/트랜스포존 조합을 테스트하기 위해 이러한 시스템을 사용하였다. 본 발명자들은 알려진 활성 피기백-유사 트랜스포사제에 상동성인 오픈 리딩 프레임에 대해 공개적으로 이용가능한 시퀀싱된 게놈을 검색하기 위해 컴퓨터 기법을 사용하였다. 본 발명자들은 활성 피기백-유사 트랜스포사제의 DDDE 모티프 특성을 보유하는 것으로 보이는 트랜스포사제 서열을 선택하고, 5'-TTAA-3' 표적 서열에 인접한 역반복 서열에 대해 이러한 추정적 트랜스포사제에 측접한 DNA 서열을 검색하였다. 본 발명자들이 확인한 것들 중에는 하기로부터의 온전한 트랜스포사제를 갖는 추정 트랜스포존이 있다: SEQ ID NO: 216을 갖는 추정 좌측 말단 및 SEQ ID NO: 217을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 172를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 스포돕테라 리투라(Spodoptera litura)(유전자 수탁 번호 MTZO01002002.1, 단백질 수탁 번호 XP_022823959); SEQ ID NO: 218을 갖는 추정 좌측 말단 및 SEQ ID NO: 219를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 173을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 피에리스 라패(Pieris rapae)(NCBI 게놈 참조 서열 NW_ 019093607.1, 진뱅크 단백질 수탁 번호 XP_022123753.1); SEQ ID NO: 220을 갖는 추정 좌측 말단 및 SEQ ID NO: 221를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 174를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 마이주스 퍼시캐(Myzus persicae)(NCBI 게놈 참조 서열 NW_019100532.1, 단백질 수탁 번호 XP_022166603); SEQ ID NO: 222을 갖는 추정 좌측 말단 및 SEQ ID NO: 223을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 175를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 온토파구스 타우루스(Onthophagus taurus)(NCBI 게놈 참조 서열 NW_019280463, 단백질 수탁 번호 XP_022900752); SEQ ID NO: 224를 갖는 추정 좌측 말단 및 SEQ ID NO: 225를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 176을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 템노토락스 쿠르비스피노수스(Temnothorax curvispinosus)(NCBI 게놈 참조 서열 NW_020220783.1, 단백질 수탁 번호 XP_024881886); SEQ ID NO: 226를 갖는 추정 좌측 말단 및 SEQ ID NO: 227을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 177을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 아그릴루스 플라니펜(Agrlius planipenn)(NCBI 게놈 참조 서열 NW_020442437.1, 단백질 수탁 번호 XP_025836109); SEQ ID NO: 228을 갖는 추정 좌측 말단 및 SEQ ID NO: 229를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 178을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 파라스테아토다 테피다리오룸(Parasteatoda tepidariorum)(NCBI 게놈 참조 서열 NW_018371884.1, 단백질 수탁 번호 XP_015905033); SEQ ID NO: 230을 갖는 추정 좌측 말단 및 SEQ ID NO: 231을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 179를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 펙티노포라 고스시피엘라(Pectinophora gossypiella)(단백질 수탁 번호 GU270322.1, 단백질 ID ADB45159.1, 또한, 문헌 [Wang et al, 2010. Insect Mol. Biol. 19, 177-184. "piggyBac-like elements in the pink bollworm, Pectinophora gossypiella"]에 기술됨); SEQ ID NO: 232를 갖는 추정 좌측 말단 및 SEQ ID NO: 233을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 180을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 씨테노플뤼시아 아그나타(Ctenoplusia agnata)(NCBI 수탁 번호 GU477713.1, 단백질 수탁 번호 ADV17598.1, 또한, 문헌 [Wu M, et al (2011) Genetica 139:149-54. "Cloning and characterization of piggyBac-like elements in lepidopteran insects"]에 기술됨); SEQ ID NO: 234를 갖는 추정 좌측 말단 및 SEQ ID NO: 235를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 181을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 마크로스토뭄 리그나노(Macrostomum lignano)(NCBI 게놈 참조 서열 NIVC01003029.1, 단백질 수탁 번호 PAA53757); SEQ ID NO: 236을 갖는 추정 좌측 말단 및 SEQ ID NO: 237을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 182를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 오루스수스 아비에티누스(Orussus abietinus)(NCBI 수탁 번호 XM_012421754, 단백질 수탁 번호 XP_012277177); SEQ ID NO: 238을 갖는 추정 좌측 말단 및 SEQ ID NO: 239를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 183을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 유프리에시 멕시카나(Eufriesea mexicana)(NCBI 게놈 참조 서열 NIVC01003029.1, 단백질 수탁 번호 XP_017759329); SEQ ID NO: 240을 갖는 추정 좌측 말단 및 SEQ ID NO: 241을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 184를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 스포도프테라 리투라(Spodoptera litura)(NCBI 게놈 참조 서열 NC_036206.1, 단백질 수탁 번호 XP_022824855); SEQ ID NO: 242를 갖는 추정 좌측 말단 및 SEQ ID NO: 243를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 185를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 바네사 타메아매(Vanessa tameamea)(NCBI 게놈 참조 서열 NW_020663261.1, 단백질 수탁 번호 XP_026490968); SEQ ID NO: 244을 갖는 추정 좌측 말단 및 SEQ ID NO: 245를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 186을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 블라텔라 게르마니카(Blattella germanica)(NCBI 게놈 참조 서열 PYGN01002011.1, 단백질 수탁 번호 PSN31819); SEQ ID NO: 246을 갖는 추정 좌측 말단 및 SEQ ID NO: 247을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 187를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 온토파구스 타우루스(Onthophagus taurus)(NCBI 게놈 참조 서열 NW_019281532.1, 단백질 수탁 번호 XP_022910826); SEQ ID NO: 248을 갖는 추정 좌측 말단 및 SEQ ID NO: 249를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 188을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 온토파구스 타우루스(Onthophagus taurus)(NCBI 게놈 참조 서열 NW_019281689.1, 단백질 수탁 번호 XP_022911139); SEQ ID NO: 250을 갖는 추정 좌측 말단 및 SEQ ID NO: 251을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 188을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 온토파구스 타우루스(Onthophagus taurus)(NCBI 게놈 참조 서열 NW_019286114.1, 단백질 수탁 번호 XP_022913435); SEQ ID NO: 252를 갖는 추정 좌측 말단 및 SEQ ID NO: 253을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 190을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 메가칠 로툰데이타(Megachile rotundata)(NCBI 게놈 참조 서열 NW_003797295, 단백질 수탁 번호 XP_012145925); SEQ ID NO: 254를 갖는 추정 좌측 말단 및 SEQ ID NO: 255를 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 191를 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 지포포루스 마쿨라투스(Xiphophorus maculatus)(NCBI 게놈 참조 서열 NC_036460.1, 단백질 수탁 번호 XP_023207869); 및 SEQ ID NO: 1을 갖는 추정 좌측 말단 및 SEQ ID NO: 3을 갖는 추정 우측 말단에 측접되어 있는 SEQ ID NO: 18을 갖는 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 갖는 아마이엘로이스 트란시텔라(Amyelois transitella)(NCBI 수탁 번호 XM_013335311, 단백질 수탁 번호 XP_013190765.1).
5.2.5.1 아마이엘로이스 트랜스포사제 및 이의 상응하는 트랜스포존
효모의 전위 활성에 의해 확인된 한 활성 트랜스포사제 및 이의 상응하는 트랜스포존은 섹션 6.1.2에 설명된 바와 같이 아마이엘로이스 트랜스포사제였다. 섹션 6.1.2에 설명된 바와 같이 아마이엘로이스 트랜스포사제는 SEQ ID NO: 18로 제공된 서열과 적어도 80%, 90%, 93%, 95%, 96%, 97%, 98%, 99% 또는 100% 동일하며, 트랜스포사제 리포터 작제물 SEQ ID NO: 192로부터 트랜스포존을 전위시킬 수 있는 폴리펩티드 서열을 포함한다. 예시적인 아마이엘로이스 트랜스포사제는 SEQ ID NO: 18-170으로서 제공된 서열을 포함한다.
아마이엘로이스 트랜스포사제는 아마이엘로이스 트랜스포사제를 인코딩하는 폴리뉴클레오티드로서 또는 단백질로서 유전자 전달 시스템의 일부로 제공될 수 있으며, 여기에서 폴리뉴클레오티드는 표적 세포에서 발현 가능하다. 폴리뉴클레오티드로서 제공되는 경우, 아마이엘로이스 트랜스포사제는 DNA 또는 mRNA로서 제공될 수 있다. DNA로서 제공되는 경우, 아마이엘로이스 트랜스포사제를 인코딩하는 오픈 리딩 프레임은 바람직하게는, 트랜스포사제가 표적 세포에서 발현 가능하도록 표적 세포에서 활성인 프로모터, 예를 들어 진핵 세포 또는 척추동물 세포 또는 포유동물 세포에서 활성인 프로모터를 포함하는 이종성 조절 요소에 작동가능하게 연결된다. mRNA로 제공되는 경우, mRNA는 시험관내에서 DNA 분자로부터 제조될 수 있으며, 여기에서 아마이엘로이스 트랜스포사제를 인코딩하는 오픈 리딩 프레임은 바람직하게는, mRNA를 제조하는데 사용된 시험관내 전사 시스템에서 활성인 이종성 프로모터, 예를 들어 T7 프로모터에 작동가능하게 연결된다.
아마이엘로이스 트랜스포존은 SEQ ID NO: 9로 제공된 서열을 갖는 좌측 ITR을 포함하는 좌측 트랜스포존 말단 및 SEQ ID NO: 10로 제공된 서열을 갖는 우측 ITR을 포함하는 우측 트랜스포존 말단에 의해 측접된 이종성 폴리뉴클레오티드를 포함하고, 여기서 각 ITR의 원위 말단은 표적 서열에 바로 인접한다. 여기 및 다른 곳에서 역 반복부가 모호성 코드에 의해 정의된 뉴클레오티드를 포함하는 서열에 의해 정의될 때, 그 뉴클레오티드의 동일성은 두개의 반복부에서 독립적으로 선택될 수 있다. 다른 사용 가능한 표적 서열이 사용될 수 있지만 바람직한 표적 서열은 5'-TTAA-3'이고; 바람직하게는 트랜스포존의 한 측에 있는 표적 서열은 트랜스포존의 다른 측에 있는 표적 서열의 직접 반복부이다. 좌측 트랜스포존 말단은 ITR에 근접한 추가 서열, 예를 들어 SEQ ID NO: 7 또는 SEQ ID NO: 13과 적어도 90% 동일하거나 100% 동일한 서열을 추가로 포함할 수 있다. 우측 트랜스포존 말단은 ITR에 근접한 추가 서열, 예를 들어 SEQ ID NO: 8 또는 SEQ ID NO: 16과 적어도 90% 동일하거나 100% 동일한 서열을 추가로 포함할 수 있다. 대표적인 아마이엘로이스 트랜스포존의 구조는 도 1에 도시되어 있다. 아마이엘로이스 트랜스포존은 예를 들어 Gal1 프로모터에 작동가능하게 연결된 SEQ ID NO: 171로 제공된 서열을 갖는 폴리뉴클레오티드에 의해 인코딩된 바와 같은 SEQ ID NO: 18로 제공된 폴리펩티드 서열을 갖는 트랜스포사제에 의해 전위될 수 있다.
ITR 및 표적 서열을 포함하는 트랜스포존 말단은 이종성 폴리뉴클레오티드 서열의 말단에 추가되어 아마이엘로이스 트랜스포사제에 의해 표적 진핵생물 게놈으로 효율적으로 전위될 수 있는 합성 아마이엘로이스 트랜스포존을 생성할 수 있다. 예를 들어, SEQ ID NO: 1 및 SEQ ID NO: 2 각각은 합성 아마이엘로이스 트랜스포존을 생성하기 위해 좌측 5'-TTAA-3' 표적 서열에 이어서 좌측 트랜스포존 ITR에 이어서 이종성 폴리뉴클레오티드의 한 측에 추가될 수 있는 추가 말단 서열을 포함하고, 표적 서열은 이종성 폴리뉴클레오티드에 대해 원위이다. SEQ ID NO: 3, 및 SEQ ID NO: 4 각각은 합성 아마이엘로이스 트랜스포존을 생성하기 위해 추가적인 말단 서열에 이어서 우측 트랜스포존 ITR 서열에 이어서 이종성 폴리뉴클레오티드의 다른 측에 부가될 수 있는 우측 5'-TTAA-3' 표적 서열을 포함하고, 표적 서열은 이종성 폴리뉴클레오티드에 대해 원위이다. 선행하는 트랜스포존 말단 서열은, 합성 아마이엘로이스 트랜스포존을 생성하기 위해 표적 서열로서 5'-TTAA-3'을 포함하지만, SEQ ID NO: 5는 좌측 트랜스포존 ITR에 이어서 이종성 폴리뉴클레오티드의 한 측에 추가될 수 있는 추가적인 말단 서열을 포함하며, ITR 서열이 이종성 폴리뉴클레오티드 서열에 대해 원위이며, SEQ ID NO: 6은 추가적인 말단 서열에 이어서 이종성 폴리뉴클레오티드의 다른 측에 추가될 수 있는 우측 트랜스포존 ITR 서열을 포함하며, 표적 서열은 이종성 폴리뉴클레오티드에 대해 원위이며, 상기 합성 아마이엘로이스 트랜스포존은 그 후 대안적인 표적 서열에 측접될 수 있다.
아마이엘로이스 트랜스포사제는 합성 아마이엘로이스 트랜스포존을 인식한다. 이들은 한 트랜스포존 말단의 좌측 말단에 있는 표적 서열 및 제2 트랜스포존 말단의 우측 말단에 있는 표적 서열에서 DNA를 절단함으로써 제1 DNA 분자로부터 트랜스포존을 절제하고, 제1 DNA 분자의 절단 말단부를 재결합시켜 표적 서열의 단일 복사체를 남긴다. 트랜스포존 말단 사이에 있는 임의의 이종성 DNA를 포함하는 절제된 트랜스포존 서열은 트랜스포사제에 의해 표적 세포의 게놈과 같은 제2 DNA 분자의 표적 서열에 통합된다. 게놈이 합성 아마이엘로이스 트랜스포존을 포함하는 세포는 본 발명의 한 구체예이다.
5.2.5.2 아마이엘로이스 트랜스포사제는 포유동물 세포에서 활성이다
로퍼 나방 피기백 트랜스포사제는 매우 광범위한 진핵 세포에서 활성인 것으로 나타났다. 섹션 6.1.2에서 본 발명자들은 아마이엘로이스 트랜스포사제가 이의 상응하는 트랜스포존을 효모 사카로마이세스 세레비시애의 게놈 내로 전위시킬 수 있음을 보여준다. 섹션 6.1.3에서 본 발명자들은 아마이엘로이스 트랜스포사제가 이의 상응하는 트랜스포존을 포유동물 CHO 세포의 게놈 내로 전위시킬 수 있음을 보여준다. 이러한 결과는 알려진 다른 활성 피기백-유사 트랜스포사제와 마찬가지로, 아마이엘로이스 트랜스포사제가 또한 대부분의 진핵 세포의 게놈 내로 이의 상응하는 트랜스포존을 전위시키는데 있어서 활성이라는 증거를 제공한다. 아마이엘로이스 트랜스포사제가 광범위한 진핵 세포에서 활성이지만, 아마이엘로이스 트랜스포사제(SEQ ID NO: 929로 제공)를 인코딩하는 자연 발생 오픈 리딩 프레임은 유사하게 광범위한 세포에서 잘 발현되지 않을 것으로 보이는데, 이는 최적의 코돈 사용이 세포 유형에 따라 현저하게 다르기 때문이다. 따라서, 트랜스포사제를 인코딩하기 위해 자연 발생 서열 이외의 서열을 사용하는 것이, 즉 발현이 수행될 세포 유형의 코돈-선호도를 이용하는 것이 유리하다. 마찬가지로, 프로모터 및 다른 조절 서열은 발현이 수행될 세포 유형에서 활성이 되도록 선택된다. 아마이엘로이스 트랜스포사제의 발현을 위한 유리한 폴리뉴클레오티드는 폴리뉴클레오티드와 SEQ ID NO: 929 사이의 상응하는 위치에서 SEQ ID NO: 929와 비교해 적어도 2, 5, 10, 20, 30, 40 또는 50개의 동의 코돈 차이를 포함하고, 임의적으로 여기에서 상응하는 위치에 있는 폴리뉴클레오티드의 코돈은 포유동물 세포 발현을 위해 선택된다. SEQ ID NO: 18, 96 및 170으로 제공된 폴리펩티드 서열을 갖는 아마이엘로이스 트랜스포사제에 대한 예시적인 폴리뉴클레오티드 서열로서, 코돈이 포유동물 세포 발현을 위해 선택되는 폴리뉴클레오티드 서열은 각각 SEQ ID NO: 171, 930 및 931로서 제공된다. 폴리뉴클레오티드는 DNA 또는 mRNA일 수 있다.
5.2.6 과활성 아마이엘로이스 트랜스포사제
개별적인 유리한 돌연변이는 다양한 상이한 방식으로, 예를 들어, "DNA 셔플링"에 의해 또는 미국 특허 8,635,029 B2에 기술된 방법에 의해 또는 미국 특허 8,635,029 B2 및 문헌 [Liao et al (2007, BMC Biotechnology 2007, 7:16 doi:10.1186/1472-6750-7-16 "Engineering proteinase K using machine learning and synthetic genes")]에 기술된 방법에 의해 조합될 수 있다. 신규한 표적 서열에 대한 활성 또는 기존 표적 서열에 대한 증가된 활성을 위해 변형된 활성을 갖는 트랜스포사제는 적절한 상응하는 트랜스포존과 본원에 기술된 선택 계획의 변형을 사용하여 수득될 수 있다(예를 들어, 섹션 6.1.6).
공지된 활성 피기백-유사 트랜스포사제의 정렬을 사용하여 활성을 향상시킬 가능성이 높은 아미노산 변화를 식별할 수 있다. 트랜스포사제는 종종 이들의 숙주에 해로우며, 따라서 이들을 비활성화시키는 돌연변이를 축적하는 경향이 있다. 그러나, 다양한 트랜스포사제에 축적되는 돌연변이는 각각 무작위로 발생하기 때문에 상이하다. 컨센서스 서열은 서열 정렬로부터 얻어질 수 있으며, 이는 활성을 개선하는데 사용될 수 있다(Ivics et al, 1997. Cell 91: 501-510. "Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells."). 본 발명자들은 CLUSTAL 알고리즘을 사용하여 알려진 활성 피기백-유사 트랜스포사제를 정렬하고, 각 위치에서 발견되는 아미노산을 열거하였다. 이러한 다양성은 아마이엘로이스 트랜스포사제(SEQ ID NO: 18과 관련하여)와 관련하여 표 1에 도시되며, C 열에 제시된 아미노산은 정렬의 등가 위치에서 알려진 활성 피기백-유사 트랜스포사제에서 발견되며, 따라서 아마이엘로이스 트랜스포사제에서 변화를 허용할 가능성이 높다. D 열은 나머지 트랜스포사제 세트 내에서 양호한 보존이 있지만 아마이엘로이스 트랜스포사제 서열의 아미노산이 이상값인 위치에서 아마이엘로이스 트랜스포사제 이외의 알려진 활성 피기백-유사 트랜스포사제에서 발견되는 아미노산 변화를 보여준다. A 열에 제시된 위치의 D 열에 제시된 아미노산으로의 돌연변이는 특히 향상된 트랜스포사제 활성을 발생시킬 가능성이 높다.
본 발명자들은 표 1의 D 열에서 아마이엘로이스 트랜스포사제 SEQ ID NO: 18에서 만들 59개 아미노산 치환을 선택하였다. 치환은 P65E, D79N, R95S, V100I, V106P, L115D, E116P, H121Q, V131E, K139E, T159N, V166F, G174A, G179N, W187F, P198R, L203R, I209L, N211R, A225R, P232A, E238D, V261L, L273M, L273I, D304R, D304K, Y310G, I323L, Q329G, Q329R, M336C, Y343I, T345L, K362R, T366R, C367E, T380S, L408M, E413S, S416E, I426M, K432Q, S435G, K442Q, N452K, L458M, N466D, T467M, A472S, V475I, N483K, I491M, A529P, K540R, D551R, S560K, T562K 및 S563K였다. 이러한 치환의 조합을 포함하는 아마이엘로이스 트랜스포사제 변이체를 인코딩하는 유전자를 합성하고, 섹션 6.1.6에 기술된 바와 같은 트랜스포사제 활성에 대해 테스트하였다. 본 발명자들은 자연 발생 서열 SEQ ID NO: 18과 비교해 증가된 절제 또는 전위 활성을 갖는 70개 초과의 아마이엘로이스 트랜스포사제 변이체를 확인하였다. 과활성 아마이엘로이스 트랜스포사제 변이체의 예시적인 서열은 SEQ ID NO: 96-170으로서 제공된다. 특히, 활성 아마이엘로이스 트랜스포사제 변이체는 SEQ ID NO: 114-170으로서 제공된다.
따라서, 자연 발생 서열은 아니지만, SEQ ID NO: 18과 적어도 99%, 98%, 97%, 96%, 95%, 90% 또는 적어도 80% 동일한 아마이엘로이스 트랜스포사제가 생성될 수 있다. 이러한 변이체는 SEQ ID NO: 18의 트랜스포사제의 부분적 활성을 유지할 수 있거나(전위 및/또는 절제 활성 중 어느 하나 또는 둘 모두에 의해 결정됨), 전위 및 절제 중 어느 하나 또는 이 둘 모두에서 SEQ ID NO: 18의 트랜스포사제와 기능적으로 동등할 수 있거나, 전위, 절제, 활성 또는 이 둘 모두에서 SEQ ID NO: 18의 트랜스포사제에 비해 향상된 활성을 가질 수 있다. 이러한 변이체는 전위 및/또는 절제를 증가시키기 위해 본원에 제시된 돌연변이, 전위 및/또는 절제에 대해 중립적인 것으로 본원에 나타난 돌연변이, 및 전위 및/또는 통합에 유해한 돌연변이를 포함할 수 있다. 바람직한 변이체는 중성이거나 전위 및/또는 절제를 향상시키는 것으로 나타난 돌연변이를 포함한다. 일부 이러한 변이체는 전위 및/또는 절제에 유해한 것으로 나타난 돌연변이가 결여되어 있다. 일부 이러한 변이체는 단지 전위를 향상시키는 것으로 나타난 돌연변이, 단지 절제를 향상시키는 것으로 나타난 돌연변이 또는 전위 및 절제 둘 모두를 향상시키는 것으로 나타난 돌연변이를 포함한다.
향상된 활성은 변이체가 파생되는 참조 트랜스포사제의 활성보다 실험 오류를 넘어 더 큰 활성(예를 들어, 전위 또는 절제 활성)을 의미한다. 활성은 참조 트랜스포사제의 예를 들어, 1.5, 2, 5, 10, 15, 20, 50 또는 100배 계수만큼 더 클 수 있다. 향상된 활성은 참조 트랜스포사제의 예를 들어, 2-100배, 2-50배, 5-50배 또는 2-10배의 범위 내에 있을 수 있다. 여기 및 다른 곳에서 활성은 실시예에 입증된 바와 같이 측정될 수 있다.
기능적 동등성은 변이 트랜스포사제가 참조 트랜스포사제에 필적하는 효율(실험 오차 내)로 동일한 트랜스포존의 전위 및/또는 절제를 매개할 수 있음을 의미한다. 자연 발생 아마이엘로이스 트랜스포사제 SEQ ID NO: 18에 필적하는 전위 빈도를 갖는 변이 아마이엘로이스 트랜스포사제의 17개의 대표적인 서열은 SEQ ID NO: 19-35이다.
또한, SEQ ID NO:18의 변이체 서열은 표 1 D 열로부터 선택된 2, 3, 4 또는 5개 이상의 치환을 조합함으로써 생성될 수 있다. 유익한 치환, 예를 들어 표 1의 D 열에 도시된 것들의 조합은 SEQ ID NO: 18의 과활성 변이체를 발생시킬 수 있다. 본 발명자들은 자연 발생 아마이엘로이스 트랜스포사제 SEQ ID NO: 18의 것보다 약 2배 초과로 더 큰 전위 또는 절제 빈도를 갖는 70개 초과의 아마이엘로이스 트랜스포사제(SEQ ID NO: 96-170으로서 제공된 서열 포함)를 확인하였다. 이들 바람직한 과활성 아마이엘로이스 트랜스포사제는 (SEQ ID NO: 18과 비교해) 하기 치환 중 하나 이상을 포함하였다: D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K. 일부 과활성 아마이엘로이스 트랜스포사제는 이종성 핵 국소화 서열을 추가로 포함할 수 있다.
본 발명자들은 문헌 [2007, BMC Biotechnology 2007, 7:16 doi:10.1186/1472-6750-7-16 "Engineering proteinase K using machine learning and synthetic genes"]에 기술된 바와 같은 기계 학습 방법을 사용하여 아마이엘로이스 트랜스포사제의 절제 및 전위 활성에 대한 다양한 아미노산 치환의 효과를 결정하였다. 각각의 치환은 최소 5개의 상이한 서열 맥락에서 (즉, 상이한 다른 아미노산 치환의 존재하에) 경험적으로 시험되었다. 문헌 [Liao et. al.]에 기술된 바와 같이, 치환에 대한 회귀 가중치의 평균 값은 여러 상이한 아마이엘로이스 트랜스포사제 내에서 해당 치환의 평균 효과의 측정치이다. 양의 평균 회귀 가중치를 갖는 치환은 평균적으로 아마이엘로이스 트랜스포사제의 전위 활성에 대한 긍정적인 효과를 갖는 것이다. 따라서, 이러한 치환을 이미 포함하지 않은 활성 아마이엘로이스 트랜스포사제에 대한 양의 평균 회귀 가중치를 갖는 치환의 추가는 이러한 아마이엘로이스 트랜스포사제의 전위 활성을 개선할 것으로 예상된다. 표 8은 전위에 있어서 양의 평균 회귀 가중치를 갖는 아마이엘로이스 트랜스포사제 내의 32개 치환을 확인시켜준다: D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K.
SEQ ID NO: 18-35 또는 96-170은 SEQ ID NO: 18과 비교해, 아미노산 79, 95, 115, 116, 121, 139, 166, 179, 187, 198, 203, 211, 238, 273, 304, 329, 345, 362, 366, 408, 416, 435, 458, 475, 483, 491, 529, 540, 560 및 563으로부터 선택된 위치에서 치환을 포함한다. 바람직하게는, 치환은 표 1 C 또는 D 열에 나타낸 것이다. 바람직하게는, 과활성 아마이엘로이스 트랜스포사제는 SEQ ID NO: 18의 서열과 비교해, D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K, 또는 이들 돌연변이의 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 또는 전부를 포함하는 이의 치환의 임의의 조합으로부터 선택되는 아미노산 치환 포함한다. 과활성 아마이엘로이스 트랜스포사제는 또한 강화된 전위와 연관되지 않은 많은 다른 위치에서의 치환, 예를 들어 전위에 중립적 효과를 갖는 보존적 치환을 포함한다.
바람직한 과활성 아마이엘로이스 트랜스포사제는 자연 발생 단백질 이외의 아미노산 서열(예를 들어, 아미노산 서열이 SEQ ID NO: 18을 포함하는 트랜스포사제는 아님)을 포함하며, 이는 SEQ ID NO: 18-35 또는 96-170 중 임의의 아미노산 서열에 대해 적어도 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% 또는 100% 동일하고, SEQ ID NO: 18과 비교해 아미노산 79, 95, 115, 116, 121, 139, 166, 179, 187, 198, 203, 211, 238, 273, 304, 329, 345, 362, 366, 408, 416, 435, 458, 475, 483, 491, 529, 540, 560 및 563으로부터 선택된 위치에서 치환을 포함한다. 바람직하게는, 치환은 표 1 C 또는 D 열에 나타낸 것이다. 바람직하게는, 과활성 아마이엘로이스 트랜스포사제는 SEQ ID NO: 18의 서열과 비교해, D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K, 또는 이들 돌연변이의 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 또는 전부를 포함하는 이의 치환의 임의의 조합로부터 선택되는 아미노산 치환 포함한다.
자연 발생 또는 과활성 아마이엘로이스 트랜스포사제를 사용하여 트랜스제닉 세포를 생성하는 방법은 본 발명의 한 양태이다. 트랜스제닉 세포를 생성하는 방법은 (i) 자연 발생 또는 과활성 아마이엘로이스 트랜스포사제(단백질로서 또는 트랜스포사제를 인코딩하는 폴리뉴클레오티드로서) 및 상응하는 아마이엘로이스 트랜스포존을 진핵 세포에 도입하는 것을 포함한다. 트랜스제닉 세포를 생성하는 것은 (ii) 아마이엘로이스 트랜스포존이 진핵 세포의 게놈 내로 통합된 세포를 확인하는 것을 추가로 포함할 수 있다. 아마이엘로이스 트랜스포존이 진핵 세포의 게놈에 통합된 세포를 확인하는 것은 아마이엘로이스 트랜스포존에 인코딩된 선택가능 마커에 대해 진핵 세포를 선택하는 것을 포함할 수 있다. 선택가능 마커는 본원에 기술된 임의의 것을 포함하여 임의의 선택가능 폴리펩티드일 수 있다.
트랜스포사제의 활성은 또한 N-말단, C-말단, N-말단 및 C-말단 둘 모두에서 또는 트랜스포사제 활성이 유지되는 한 트랜스포사제 단백질의 내부 영역에서 핵 국소화 신호(NLS)의 융합에 의해 증가될 수 있다. 핵 국소화 신호 또는 서열(NLS)은 세포 핵으로의 내입을 위한 핵 수송 단백질과의 단백질의 상호작용을 직접적으로 또는 간접적으로 '태그'하거나 촉진하는 아미노산이다. 사용된 핵 국소화 신호(NLS)는 컨센서스 NLS 서열, 바이러스 NLS 서열, 세포 NLS 서열 및 이들의 조합을 포함할 수 있다.
트랜스포사제는 또한 다른 단백질 기능성 도메인에 융합될 수 있다. 이러한 단백질 기능성 도메인은 DNA 결합 도메인, 하나 이상의 도메인 융합을 촉진할 수 있는 가요성 힌지 영역, 및 이들의 조합을 포함할 수 있다. 융합은 트랜스포사제 활성이 유지되는 한 트랜스포사제 단백질의 N-말단, C-말단 또는 내부 영역에 만들어질 수 있다. DNA 결합 도메인에 대한 융합을 사용하여 아마이엘로이스 트랜스포사제를 특정 게놈 유전자좌 또는 유전자좌들로 지향시킬 수 있다. DNA 결합 도메인은 나선-회전-나선 도메인, 아연-핑거 도메인, 류신 지퍼 도메인, TALE(전사 활성제-유사 이펙터) 도메인, CRISPR-Cas 단백질 또는 나선-루프-나선 도메인을 포함할 수 있다. 사용된 특정 DNA 결합 도메인은 Gal4 DNA 결합 도메인, LexA DNA 결합 도메인, 또는 Zif268 DNA 결합 도메인을 포함할 수 있다. 사용된 가요성 힌지 영역은 글리신/세린 링커 및 이의 변이체를 포함할 수 있다.
5.3 키트
본 발명은 또한 단백질로서 또는 핵산에 의해 인코딩된 아마이엘로이스 트랜스포사제, 및/또는 아마이엘로이스 트랜스포존; 또는 아마이엘로이스 트랜스포존과 조합된 단백질로서 또는 본원에 기술된 바와 같은 핵산에 의해 인코딩된 아마이엘로이스 트랜스포사제를 포함하는 본원에 기술된 바와 같은 유전자 전달 시스템; 임의적으로 약학적으로 허용되는 담체, 애주번트 또는 비히클을 함께 및 임의적으로 사용 설명서를 함께 포함하는 키트를 특징으로 한다. 본 발명의 키트의 임의의 구성요소는 후속 순서로 또는 동시에 세포 내로 투여되고/거나 형질감염될 수 있으며, 예를 들어, 아마이엘로이스 트랜스포사제 단백질 또는 이의 인코딩 핵산은 아마이엘로이스 트랜스포존의 투여 및/또는 형질감염 전에, 이와 동시에 또는 후에 상기 정의된 바와 같은 세포 내로 투여되고/거나 형질감염될 수 있다. 대안적으로, 아마이엘로이스 트랜스포존은 아마이엘로이스 트랜스포사제 단백질 또는 이의 인코딩 핵산의 형질감염 전에, 이와 동시에 또는 후에 상기 정의된 바와 같은 세포 내로 형질감염될 수 있다. 동시에 형질감염되는 경우, 바람직하게는 두 구성요소 둘 모두는 형질감염 전에 전위를 회피하기 위해 투여 직전에 서로 분리된 제형으로 및/또는 혼합되어 제공된다. 추가로, 키트의 적어도 하나의 구성요소의 투여 및/또는 형질감염은 예를 들어, 이 구성요소의 다중 용량을 투여함으로써 시차 방식으로 발생할 수 있다.
6. 실시예
하기 실시예는 본원에 개시된 방법, 조성물 및 키트를 예시하고, 어떠한 방식으로든 제한하는 것으로 해석되어서는 안 된다. 다양한 등가물은 다음 예로부터 명백해질 것이다; 이러한 등가물은 또한 본원에 개시된 본 발명의 일부로 고려된다.
6.1 새로운 트랜스포사제
6.1.1 트랜스포사제 활성 측정
섹션 5.2.5에 설명된 바와 같이, 활성 트랜스포사제의 전위 빈도는 트랜스포존이 선택가능 마커를 방해하는 시스템을 사용하여 측정될 수 있다. 효모 사카로마이세스 세레비시애 URA3 오픈 리딩 프레임의 오픈 리딩 프레임이 프로모터 및 터미네이터에 효모 사카로마이세스 세레비시애에서 발현되도록 작동가능하게 연결된 효모 TRP 1 오픈 리딩 프레임에 의해 방해되는 트랜스포사제 리포터 폴리뉴클레오티드를 작제하였다. TRP1 유전자가 5'-TTAA-3' 표적 부위를 갖는 추정 트랜스포존 말단에 측접되어, 추정 트랜스포존의 절제는 5'-TTAA-3' 표적 부위의 단일 복사체를 남기고 URA3 오픈 리딩 프레임을 정확하게 재구성할 것이다. 효모 트랜스포사제 리포터 균주는, LEU2 및 TRP1에 대한 보조영양성인 반수성 효모 균주의 URA3 유전자 내로 트랜스포사제 리포터 폴리뉴클레오티드를 통합시켜 균주가 LEU2-, URA3- 및 TRP1+이 되도록 작제하였다.
URA3 오픈 리딩 프레임 내부로부터 TRP1 유전자-함유 트랜스포존을 전위시키는 트랜스포사제의 능력에 대해 테스트하였다. 추정 트랜스포사제를 인코딩하는 각각의 오픈 리딩 프레임을 사카로마이세스에서 발현가능한 LEU2 유전자 및 2 미크론 복제 기점을 포함하는 사카로마이세스 세레비시애 발현 벡터 내로 클로닝하였다. 각각의 트랜스포사제 오픈 리딩 프레임은 Gal1 프로모터에 작동가능하게 연결하였다. 각각의 클로닝된 트랜스포사제 오픈 리딩 프레임을 효모 트랜스포사제 리포터 균주로 형질전환시키고, 류신이 결핍된 최소 배지에 플레이팅하였다. 2일 후, 모든 LEU+ 콜로니를 플레이트를 스크래핑하여 수확하였다. Gal 프로모터는 갈락토스에서 4시간 동안 성장시켜 유도한 다음, 세포를 3개의 상이한 플레이트에 플레이팅하였다: 류신만 결여된 플레이트, 류신 및 우라실이 결여된 플레이트, 및 류신, 우라실 및 트립토판이 결여된 플레이트. 이들 플레이트를 2-4일 동안 인큐베이션하고, 각 플레이트 상의 콜로니를 계수하여 살아 있는 세포의 수, 트랜스포존 절제 사례의 수 및 트랜스포존 절제 및 재통합(즉, 전위 사례)의 수를 각각 측정하였다.
6.1.2 활성 아마이엘로이스 피기백-유사 트랜스포사제의 확인
섹션 5.2.5에 설명된 바와 같이, 트리코플뤼시아니로부터의 피기백 트랜스포사제와 적어도 20% 동일한 것으로서 21개 추정 피기백-유사 트랜스포사제를 진뱅크로부터 확인하였다. 이러한 추정 트랜스포사제는 활성 피기백-유사 트랜스포사제 특유의 DDDE 모티프를 포함하는 것으로 나타났다. 측접 DNA 서열을 피기백 전위의 특징인 5'-TTAA-3' 표적 서열에 바로 인접한 역방위 반복 서열의 존재에 대해 분석하였다. 5'-TTAA-3' 표적 서열과 추정 트랜스포사제를 인코딩하는 오픈 리딩 프레임 사이의 서열을 포함하는 추정적 좌측 및 우측 트랜스포존 말단 서열을 이들 측접 서열로부터 취하였다. 이러한 트랜스포존 말단을 섹션 6.1.1에 설명된 바와 같이 구성된 트랜스포사제 리포터 작제물에 혼입하고, 사카로마이세스 세레비시애의 게놈에 통합함으로써 트랜스포사제 리포터 균주를 생성하였다. 각 리포터 균주에 대한 상응하는 트랜스포사제 서열을 역번역하고, 합성하고, 사카로마이세스 세레비시애 발현 벡터로 클로닝하고, 리포터 균주로 형질전환시켰다. 트랜스포사제 활성은 섹션 6.1.1에 설명된 바와 같이 측정하였다.
다음 20개 조합은 절제 또는 전위를 나타내지 않았다: 리포터 작제물 SEQ ID NO: 196(추정 좌측 트랜스포존 말단 SEQ ID NO: 216, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 217 포함)과 트랜스포사제 SEQ ID NO: 172, 리포터 작제물 SEQ ID NO: 197(추정 좌측 트랜스포존 말단 SEQ ID NO: 218, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 219 포함)과 트랜스포사제 SEQ ID NO: 173, 리포터 작제물 SEQ ID NO: 198(추정 좌측 트랜스포존 말단 SEQ ID NO: 220, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 221 포함)과 트랜스포사제 SEQ ID NO: 174, 리포터 작제물 SEQ ID NO: 199(추정 좌측 트랜스포존 말단 SEQ ID NO: 222, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 223 포함)과 트랜스포사제 SEQ ID NO: 175, 리포터 작제물 SEQ ID NO: 200(추정 좌측 트랜스포존 말단 SEQ ID NO: 224, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 225 포함)과 트랜스포사제 SEQ ID NO: 176, 리포터 작제물 SEQ ID NO: 201(추정 좌측 트랜스포존 말단 SEQ ID NO: 226, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 227 포함)과 트랜스포사제 SEQ ID NO: 177, 리포터 작제물 SEQ ID NO: 202(추정 좌측 트랜스포존 말단 SEQ ID NO: 228, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 229 포함)과 트랜스포사제 SEQ ID NO: 178, 리포터 작제물 SEQ ID NO: 203(추정 좌측 트랜스포존 말단 SEQ ID NO: 230, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 231 포함)과 트랜스포사제 SEQ ID NO: 179, 리포터 작제물 SEQ ID NO: 204(추정 좌측 트랜스포존 말단 SEQ ID NO: 232, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 233 포함)과 트랜스포사제 SEQ ID NO: 180, 리포터 작제물 SEQ ID NO: 205(추정 좌측 트랜스포존 말단 SEQ ID NO: 234, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 235 포함)과 트랜스포사제 SEQ ID NO: 181, 리포터 작제물 SEQ ID NO: 206(추정 좌측 트랜스포존 말단 SEQ ID NO: 236, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 237 포함)과 트랜스포사제 SEQ ID NO: 182, 리포터 작제물 SEQ ID NO: 207(추정 좌측 트랜스포존 말단 SEQ ID NO: 238, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 239 포함)과 트랜스포사제 SEQ ID NO: 183, 리포터 작제물 SEQ ID NO: 208(추정 좌측 트랜스포존 말단 SEQ ID NO: 240, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 241 포함)과 트랜스포사제 SEQ ID NO: 184, 리포터 작제물 SEQ ID NO: 209(추정 좌측 트랜스포존 말단 SEQ ID NO: 242, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 243 포함)과 트랜스포사제 SEQ ID NO: 185, 리포터 작제물 SEQ ID NO: 210(추정 좌측 트랜스포존 말단 SEQ ID NO: 244, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 245 포함)과 트랜스포사제 SEQ ID NO: 186, 리포터 작제물 SEQ ID NO: 211(추정 좌측 트랜스포존 말단 SEQ ID NO: 246, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 247 포함)과 트랜스포사제 SEQ ID NO: 187, 리포터 작제물 SEQ ID NO: 212(추정 좌측 트랜스포존 말단 SEQ ID NO: 248, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 249 포함)과 트랜스포사제 SEQ ID NO: 188, 리포터 작제물 SEQ ID NO: 213(추정 좌측 트랜스포존 말단 SEQ ID NO: 250, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 251 포함)과 트랜스포사제 SEQ ID NO: 189, 리포터 작제물 SEQ ID NO: 214(추정 좌측 트랜스포존 말단 SEQ ID NO: 252, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 253 포함)과 트랜스포사제 SEQ ID NO: 190, 리포터 작제물 SEQ ID NO: 215(추정 좌측 트랜스포존 말단 SEQ ID NO: 254, 및 추정 우측 트랜스포존 말단 SEQ ID NO: 255 포함)과 트랜스포사제 SEQ ID NO: 191, 이는, 트리코플뤼시아니로부터의 피기백 트랜스포사제와 상동성인 서열의 컴퓨터 인식은 복잡하지 않았으나, 이들 서열의 대부분은 말단 반복부가 손상되지 않은 것처럼 보이고 트랜스포사제가 활성 피기백-유사 트랜스포사제에서 발견되는 DDDE 모티프를 포함하는 것으로 보임에도 불구하고, 이들 서열 대부분이 전위에 있어서 불활성이라는 문헌의 보고와 일관된다. 따라서, 신규한 활성 피기백-유사 트랜스포사제 및 트랜스포존을 식별하기 위해 절제 및 전위 활성을 측정하는 것이 필요하다.
리포터 작제물(URA+ 콜로니의 출현으로 나타냄)로부터 이의 상응하는 트랜스포존을 절제하고, 트랜스포존의 TRP 유전자를 사카로마이세스 세레비시애 리포터 균주에서의 또 다른 게놈 위치로 전위시키는데 있어서 우수한 활성을 보여주는 한 트랜스포사제는 트랜스포사제 SEQ ID NO:18이었다. 트랜스포사제 SEQ ID NO: 18은 리포터 작제물 SEQ ID NO: 192로부터의 트랜스포존을 전위시킬 수 있었다. 이는 표 2에 나와 있다: URA+ 콜로니의 출현으로 측정된, 절제 사례의 수는 G 열에 나타낸다; URA+TRP+ 콜로니의 출현으로 측정된, 전체 전위 사례의 수는 H 열에 나타낸다.
6.1.3 아마이엘로이스 트랜스포사제는 포유동물 세포에서 활성이다
피기백-유사 트랜스포사제는 이들의 상응하는 트랜스포존을 효모 세포 예컨대, 피치아 피스토리스(Pichia pastoris) 및 사카로마이세스 세레비시애, 및 포유동물 세포 예컨대, 인간 배아 신장(HEK) 및 차이니즈 햄스터 난소(CHO) 세포를 포함하는 진핵 세포의 게놈 내로 전위시킬 수 있다. 포유동물 세포에서 피기백-유사 트랜스포사제의 활성을 결정하기 위해, 본 발명자들은 트랜스포존 말단을 포함하고, SEQ ID NO: 282로 제공된 DNA 서열에 의해 인코딩되고, 약한 글루타민 합성효소 발현을 제공하는 조절 요소에 작동가능하게 연결된 SEQ ID NO: 277로 제공된 폴리펩티드 서열을 갖는 글루타민 합성효소를 인코딩하는 선택가능 마커를 추가로 포함하는 유전자 전달 폴리뉴클레오티드를 작제하였으며, 글루타민 합성효소 및 이의 관련 조절 요소의 서열은 SEQ ID NO: 320로 제공된다. 유전자 전달 폴리뉴클레오티드는, 프로모터 및 폴리아데닐화 신호 서열에 작동가능하게 각각 연결된 항체의 경쇄 및 중쇄를 인코딩하는 오픈 리딩 프레임을 추가로 포함하였다. 유전자 전달 폴리뉴클레오티드(SEQ ID NO: 256)는 5'-TTAA-3' 표적 통합 서열을 포함하는 좌측 트랜스포존 말단에 이어서 바로 SEQ ID NO: 9의 구체예인 SEQ ID NO: 11로 제공된 ITR 서열을 갖는 아마이엘로이스 좌측 트랜스포존을 포함하였다. 유전자 전달 폴리뉴클레오티드는 SEQ ID NO: 12(이는 SEQ ID NO: 10의 구체예임)로 제공된 ITR 서열을 갖는 아마이엘로이스 우측 트랜스포존 말단에 이어서 바로 5'-TTAA-3' 표적 통합 서열을 추가로 포함하였다. 2개의 아마이엘로이스 트랜스포존 말단을, 항체의 중쇄 및 경쇄를 인코딩하는 오픈 리딩 프레임 및 글루타민 합성효소 선택가능 마커를 포함하는 이종성 폴리뉴클레오티드의 어느 한 측에 배치하였다. 좌측 트랜스포존 말단은 좌측 ITR에 바로 인접하고 이종성 폴리뉴클레오티드에 근접한 SEQ ID NO: 7로 제공된 서열을 추가로 포함하였다. 우측 트랜스포존 말단은 우측 ITR에 바로 인접하고 이종성 폴리뉴클레오티드에 근접한 SEQ ID NO: 8로 제공된 서열을 추가로 포함하였다.
유전자 전달 폴리뉴클레오티드를 기능성 글루타민 합성효소 유전자가 결여된 CHO 세포로 형질감염시켰다. 인간 CMV 프로모터 및 폴리아데닐화 신호 서열에 작동가능하게 연결된 트랜스포사제를 인코딩하는 유전자를 포함하는 3 μg의 DNA로의 공동-형질감염의 존재 또는 부재하에 25 μg의 유전자 전달 폴리뉴클레오티드 DNA로의 전기천공에 의해 세포를 형질감염시켰다. 세포를 전기천공 후 48시간 동안 4 mM 글루타민을 함유하는 배지에서 인큐베이션하고, 후속하여 글루타민이 결여된 배지에서 ml 당 300,000개 세포로 희석하였다. 세포를 5일마다 새로운 글루타민-비함유 배지로 교환하였다. 각 형질감염으로부터의 세포의 생존율을 Beckman-Coulter Vi-Cell을 사용하여 형질감염 후 다양한 시간에서 측정하였다. 또한, 생존 세포의 총 수를 동일한 기기로 측정하였다. 결과는 표 3에 제시된다.
표 3에 제시된 바와 같이, 유전자 전달 폴리뉴클레오티드로 감염되나 트랜스포사제로는 형질감염되지 않은 세포의 생존율은 형질감염후 12일까지 약 27%로 떨어졌다(B 열). 생존 세포의 총 수는 7일 이내에 ml 당 50,000개 미만으로 떨어졌다(C 열). 이러한 생존 세포 밀도에서 또는 그 미만에서, 생존율 측정은 부정확하게 된다. 배양물은 결코 회복되지 않았다. 대조적으로, SEQ ID NO: 256을 갖는 유전자 전달 폴리뉴클레오티드가 아마이엘로이스 트랜스포사제 SEQ ID NO: 18로 공동-형질감염되었을 때, 세포는 17일 이내에 90% 초과의 생존율로 회복되었으며(표 3 D 열), 이때까지 생존 세포 밀도는 ml 당 2백만 개를 초과하였다(표 3 E 열). 이는 좌측 및 우측 아마이엘로이스 트랜스포존 말단을 포함하는 유전자 전달 폴리뉴클레오티드가 상응하는 아마이엘로이스 트랜스포사제에 의해 포유동물 표적 세포의 게놈 내로 효율적으로 전위될 수 있음을 보여준다.
게놈 내로 통합된 피기백-유사 트랜스포존을 포함하는 CHO 세포의 회수된 풀을 Sigma Advanced Fed Batch 배지를 사용하여 14일 유가식으로 성장시켰다. 항체 역가를 Octet를 사용하여 배양 상청액에서 측정하였다. 표 4는 유가식 배양 7, 10, 12 및 14일에 역가를 측정하였음을 보여준다. 아마이엘로이스 트랜스포사제 SEQ ID NO: 18로의 공동-형질감에 의해 통합된, SEQ ID NO: 256을 갖는 유전자 전달 폴리뉴클레오티드를 포함하는 세포로부터의 항체 역가는 14일 후 대략 2 g/L에 도달하였다. 이는 섹션 5.2.5에 기술된 바와 같이, 아마이엘로이스 트랜스포존 및 이의 상응하는 트랜스포사제가 신규한 피기백-유사 트랜스포존/트랜스포사제 시스템이며, 이는 포유동물 세포에서 활성이며, 단백질 발현 세포주를 개발하고 포유동물 세포의 게놈을 조작하는데 유용함을 보여준다.
6.1.4 아마이엘로이스 트랜스포사제를 인코딩하는 메신저 RNA는 포유동물 세포에서 활성이다
본 발명자들은 그 구성이 섹션 6.1.3에 기술되어 있는 SEQ ID NO: 256을 갖는 유전자 전달 폴리뉴클레오티드를 추가로 테스트하여 상응하는 트랜스포사제가 mRNA 형태로 제공되는 경우 합성 아마이엘로이스 트랜스포존이 포유동물 세포의 게놈 내로 통합될 수 있는지의 여부를 결정하였다. SEQ ID NO: 256을 갖는 유전자 전달 폴리뉴클레오티드 354498은 SEQ ID NO: 282로 제공된 DNA 서열에 의해 인코딩되고, 약한 글루타민 합성효소 발현을 제공하는 조절 요소에 작동가능하게 연결되는, SEQ ID NO: 277로 제공된 폴리펩티드 서열을 갖는 글루타민 합성효소를 인코딩하는 선택가능 마커를 포함하였으며, 글루타민 합성효소 및 이의 관련 조절 요소의 서열은 SEQ ID NO: 320으로 제공된다. 유전자 전달 폴리뉴클레오티드 SEQ ID NO: 256은, 프로모터 및 폴리아데닐화 신호 서열에 작동가능하게 각각 연결된 항체의 경쇄 및 중쇄를 인코딩하는 오픈 리딩 프레임을 추가로 포함하였다. 유전자 전달 폴리뉴클레오티드 SEQ ID NO: 256은 SEQ ID NO: 1로 제공된 서열을 갖는 아마이엘로이스 좌측 트랜스포존 말단 및 SEQ ID NO: 3으로 제공된 서열을 갖는 아마이엘로이스 우측 트랜스포존 말단을 추가로 포함하였다.
아마이엘로이스 트랜스포사제를 인코딩하는 mRNA는 T7 RNA 폴리머라제를 사용하여 시험관내 전사에 의해 제조하였다. mRNA는 오픈 리딩 프레임을 선행하는 5' 서열 SEQ ID NO: 257, 아마이엘로이스 트랜스포사제를 인코딩하는 오픈 리딩 프레임(아미노산 서열 SEQ ID NO: 18, 뉴클레오티드 서열 SEQ ID NO: 171), 및 오픈 리딩 프레임 말단의 정지 코돈 다음의 3' 서열 SEQ ID NO: 258을 포함하였다. mRNA는 항-역전 캡 유사체 (3'-O-Me-m7G(5')ppp(5')G를 가졌다. 시험관내에서 활성인 이종성 프로모터에 작동가능하게 연결된 트랜스포사제를 인코딩하는 서열을 포함하는 DNA 분자는 트랜스포사제 mRNA의 제조에 유용하다. 트랜스포사제를 인코딩하는 서열을 포함하는 단리된 mRNA 분자는 상응하는 트랜스포존의 표적 게놈으로의 전위에 유용하다.
유전자 전달 폴리뉴클레오티드 SEQ ID NO: 256을 기능성 글루타민 합성효소 유전자가 결여된 CHO 세포 내로 형질감염시켰다. 세포를 전기천공에 의해 형질감염시켰다: 25 μg의 유전자 전달 폴리뉴클레오티드 DNA를 상응하는 트랜스포사제(아미노산 서열 SEQ ID NO: 18, 뉴클레오티드 서열 SEQ ID NO: 171)를 인코딩하는 오픈 리딩 프레임을 포함하는 3 μg의 mRNA로 공동-형질감염시켰다. 세포를 전기천공 후 48시간 동안 4 mM 글루타민을 함유하는 배지에서 인큐베이션하고, 후속하여 글루타민이 결여된 배지에서 ml 당 300,000개 세포로 희석하였다. 세포를 5일마다 새로운 글루타민-비함유 배지로 교환하였다. 각 형질감염으로부터의 세포의 생존율을 Beckman-Coulter Vi-Cell을 사용하여 형질감염 후 다양한 시간에서 측정하였다. 또한, 생존 세포의 총 수를 동일한 기기로 측정하였다. 결과는 표 5에 제시된다.
SEQ ID NO: 256을 갖는 유전자 전달 폴리뉴클레오티드가 아마이엘로이스 트랜스포사제 SEQ ID NO: 18을 인코딩하는 mRNA로 공동-형질감염된 경우, 생존율은 형질감염 후 9일까지 약 26%로 떨어졌으며(표 5 B 열), 이 시간까지 생존 세포의 밀도는 ml 당 약 50,000이었다(표 5 칼럼 C). 그 후, 세포 생존율 및 생존 세포의 밀도는, 형질감염 후 26일까지 생존율이 92%를 초과하고, ml 당 1백만개 초과의 생존 세포가 존재할 때까지 증가되었다. 이는 좌측 및 우측 아마이엘로이스 트랜스포존 말단을 포함하는 유전자 전달 폴리뉴클레오티드가 상응하는 아마이엘로이스 트랜스포사제를 인코딩하는 mRNA로의 공동-형질감염되는 경우 포유동물 표적 세포의 게놈 내로 효율적으로 전위될 수 있음을 보여준다.
6.1.5 포유동물 세포에서 활성인 아마이엘로이스 트랜스포존 말단 서열
본 발명자들이 아마이엘로이스 트랜스포존을 원래 테스트할 때, 본 발명자들은 트랜스포존 말단으로부터 트랜스포사제 오픈 리딩 프레임과 5'-TTAA-3' 표적 서열 사이의 전체 서열을 사용하였다. 본 발명자들은 다른 피기백-유사 서열에 있어서, 이러한 전체 서열이 일반적으로 전위 활성을 필요로 하지 않는다는 것을 발견하였다. 따라서, 본 발명자들은 절두된 말단을 갖는 합성 아마이엘로이스 트랜스포존을 작제하여 아마이엘로이스 트랜스포사제에 의해 전위가능한지의 여부를 결정하였다. SEQ ID NO: 370을 갖는 이종성 폴리뉴클레오티드는 선택가능 마커로서 약한 글루타민 합성효소 발현을 제공하는 조절 요소에 작동가능하게 연결된, SEQ ID NO: 278로 제공된 폴리펩티드 서열을 갖는 글루타민 합성효소를 인코딩하였다. 이종성 폴리뉴클레오티드의 한 측에는 5'-TTAA-3' 통합 표적 서열을 포함하는 좌측 아마이엘로이스 트랜스포존 말단이 있으며, 바로 이어서 SEQ ID NO:9의 구체예인 SEQ ID NO: 11을 갖는 트랜스포존 ITR 서열이 뒤따른다. 이종성 폴리뉴클레오티드의 다른 측에는 SEQ ID NO: 12(SEQ ID NO: 10의 구체예임)를 갖는 트랜스포존 ITR 서열을 포함하는 우측 아마이엘로이스 트랜스포존 말단이 있으며, 바로 이어서 5'-TTAA-3' 통합 표적 서열이 뒤따른다. 트랜스포존은 좌측 트랜스포존 ITR 서열(뒤)에 바로 인접하여 SEQ ID NO: 7 또는 13으로부터 선택된 추가 서열을 추가로 포함하였다. 트랜스포존은 우측 트랜스포존 ITR 서열(앞)에 바로 인접하여 SEQ ID NO: 8 또는 16으로부터 선택된 추가 서열을 추가로 포함하였다. 트랜스포존은 기능성 글루타민 합성효소 유전자가 결여된 CHO 세포 내로 형질감염시켰다. 세포를 전기천공에 의해 형질감염시켰다: 25 μg의 유전자 전달 폴리뉴클레오티드 DNA를 형질감염시키고, 임의적으로 세포를 상응하는 트랜스포사제(아미노산 서열 SEQ ID NO: 18, 뉴클레오티드 서열 SEQ ID NO: 171)를 인코딩하는 오픈 리딩 프레임을 포함하는 3 μg의 mRNA로 공동-형질감염시켰다. 세포를 전기천공 후 48시간 동안 4 mM 글루타민을 함유하는 배지에서 인큐베이션하고, 후속하여 글루타민이 결여된 배지에서 ml 당 300,000개 세포로 희석하였다. 세포를 5일마다 새로운 글루타민-비함유 배지로 교환하였다. 각 형질감염으로부터의 세포의 생존율을 Beckman-Coulter Vi-Cell을 사용하여 형질감염 후 다양한 시간에서 측정하였다. 또한, 생존가능 세포의 총 수를 동일한 기기로 측정하였다. 결과는 표 6에 제시된다.
표 6 B 열 및 C 열은 세포가 트랜스포사제의 부재하에 전장 트랜스포존 말단을 포함하는 트랜스포존으로 형질감염된 경우, 세포 생존율 및 생존가능 세포 밀도의 감소를 보여준다. 세포 생존율 및 생존가능 세포 밀도 둘 모두는 실험 전반에 걸쳐 떨어진 것으로 볼 수 있다. 대조적으로, 임의의 동일한 트랜스포존을 아마이엘로이스 트랜스포사제를 인코딩하는 mRNA로 공동-형질감염시킬 경우, 세포 생존율 및 생존 세포 밀도는 처음으로 떨어졌으나, 18일째에 회복되기 시작하였고, 25일 내지 29일 사이에 완전히 회복되었다(표 6 C 열 및 D 열). 좌측 트랜스포존 말단이 SEQ ID NO: 7로 제공된 서열로부터 SEQ ID NO: 13로 제공된 서열까지 절두된 경우 유사한 결과가 수득되었다(표 6 E 열 및 F 열을 각각 G 열 및 H 열과 비교). 우측 트랜스포존 말단이 SEQ ID NO: 8로 제공된 서열로부터 SEQ ID NO: 16으로 제공된 서열까지 절두된 경우 유사한 결과가 또한 수득되었다(표 6 I 열 및 J 열을 각각 K 열 및 L 열과 비교). 이는, SEQ ID NO: 9를 갖는 트랜스포존 ITR 서열에 바로 인접한 5'-TTAA-3' 통합 표적 서열에 더하여, 아마이엘로이스 합성 트랜스포존 좌측 트랜스포존 말단이 좌측 트랜스포존 ITR 서열에 바로 인접한 SEQ ID NO: 7 및 13으로부터 선택된 추가 서열을 추가로 포함할 수 있으며; 아마이엘로이스 합성 트랜스포존 우측 트랜스포존 말단은 우측 트랜스포존 ITR 서열에 바로 인접한 SEQ ID NO: 8 및 16으로부터 선택된 추가 서열을 포함할 수 있음을 보여준다.
6.1.6 과활성 아마이엘로이스 트랜스포사제 조작
SEQ ID NO: 18로 제공된 자연 발생 아마이엘로이스 트랜스포사제 서열과 비교해, 증가된 전위 활성 또는 증가된 절제 활성으로 이어지는 아마이엘로이스 트랜스포사제 돌연변이를 확인하기 위해, 본 발명자들은 활성 피기백-유사 트랜스포사제의 CLUSTAL 정렬을 분석하였다. 표 1 C 열은 아마이엘로이스 트랜스포사제에서 각 위치에 대한 활성 피기백-유사 트랜스포사제에서 발견된 아미노산을 보여준다(표 1 A 열에 제시된 위치). SEQ ID NO: 18로 제공된 아마이엘로이스 트랜스포사제에 존재하는 아미노산은 표 1의 B 열에 제시되어 있다. 트랜스포사제는 종종 이들의 숙주에 해롭기 때문에, 이들을 비활성화시키는 돌연변이를 축적하는 경향이 있다. 상이한 트랜스포사제에 축적되는 돌연변이는 각각 무작위로 발생하기 때문에 상이하다. 따라서, 컨센서스 서열은 유해한 돌연변이가 축적되기 이전의 조상 서열을 근사화하는데 사용될 수 있다. 소수의 현존하는 서열로부터 조상 서열을 정확하게 계산하는 것은 어려우며, 따라서, 본 발명자들은 활성 트랜스포사제가 더 많이 보존되고, 컨센서스 아미노산(들)이 아마이엘로이스 트랜스포사제 중의 것과 상이한 위치에 초점을 맞추기로 선택하였다. 본 발명자들은 다른 활성 트랜스포사제에서 발견된 컨센서스 아미노산으로 이들 아미노산을 돌연변이시키는 것은 아마이엘로이스 트랜스포사제의 활성을 증가시킬 가능성이 높을 것으로 간주하였다. 이들 후보의 유익한 아미노산 치환은 표 1 D 열에 제시된다.
6.1.6.1 아마이엘로이스 트랜스포사제 변이체의 제1 세트
변이체 아마이엘로이스 트랜스포사제를 인코딩하는 95개 유전자 세트는 P65E, D79N, R95S, V100I, V106P, L115D, E116P, H121Q, V131E, K139E, T159N, V166F, G174A, G179N, W187F, P198R, L203R, I209L, N211R, A225R, P232A, E238D, V261L, L273M, L273I, D304R, D304K, Y310G, I323L, Q329G, Q329R, M336C, Y343I, T345L, K362R, T366R, C367E, T380S, L408M, E413S, S416E, I426M, K432Q, S435G, K442Q, N452K, L458M, N466D, T467M, A472S, V475I, N483K, I491M, A529P, K540R, D551R, S560K, T562K 및 S563K로부터 선택된 하나 이상의 치환을 포함하였다. 각각의 치환은 96개 변이체 세트 내에서 적어도 5회 나타내었으며, 치환의 다양한 쌍별 조합의 수를 최대화시켜 각 치환이 가능한 많은 다양한 서열 맥락에서 테스트되도록 하였다. 각각의 변이체 유전자는 류신 선택가능 마커를 포함하는 벡터 내로 클로닝되었으며; 트랜스포사제 변이체를 인코딩하는 각 유전자는 사카로마이세스 세레비시애 Gal-1 프로모터에 작동가능하게 연결되었다. 그 후, 이들 변이체 각각은 상기 기술된 바와 같이 SEQ ID NO: 192의 염색체 통합된 복사체를 포함하는 사카로마이세스 세레비시애 균주 내로 개별적으로 형질전환되었다. 48시간 후, 세포를 플레이트로부터 스크랩핑하여 탄소원으로서 갈락토스를 가지며 류신이 결여된 최소 배지로 옮겼다. 각 배양에 대한 A600은 2로 조정하였다. 배양물을 갈락토스에서 4시간 동안 성장시켜 트랜스포사제의 발현을 유도한 다음, 100x 희석된 분취량을 류신, 우라실 및 트립토판이 결여된 배지에 플레이팅하고(전위를 계수하기 위해), 100x 희석된 분취량을 류신 및 우라실이 결여된 배지에 플레이팅하고(절제를 계수하기 위해), 25,000x 희석된 분취량을 류신이 결여된 배지에 플레이팅하였다(총 생존 세포를 계수하기 위해). 2일 후, 콜로니를 계수하여 전위(= -leu-ura-trp 배지의 세포 수를 (250 x -leu 배지의 세포수)로 나눈 값) 및 절제(= -leu-ura 배지의 세포 수를 (250 x -leu 배지의 세포수)로 나눈 값) 빈도를 결정하였다. 결과는 표 7에 제시된다. 본 발명자들은 자연 발생 아마이엘로이스 트랜스포사제에 대해 측정된 활성보다 1.2 내지 5배 더 높은 절제 또는 전위 활성을 갖는 18개의 아마이엘로이스 트랜스포사제 변이체(SEQ ID NO: 96-113으로 제공된 서열을 가짐)를 확인하였다. 본 발명자들은 자연 발생 아마이엘로이스 트랜스포사제에 필적하는 절제 또는 전위 활성을 갖는 17개 아마이엘로이스 트랜스포사제 변이체(SEQ ID NO: 19-35로 제공된 서열을 가짐)를 또한 확인하였다. 본 발명자들은 자연 발생 아마이엘로이스 트랜스포사제 보다 작은 절제 또는 전위 활성을 갖는 45개 아마이엘로이스 트랜스포사제 변이체(SEQ ID NO: 51-95로 제공된 서열을 가짐)를 또한 확인하였다. 95개 변이체 중 단지 15개(SEQ ID NO: 36-50로 제공된 서열을 가짐)만이 본질적으로 불활성일 정도로 낮은 활성을 보유하였다.
전위 빈도에 대한 서열 변화의 효과는 문헌 [Liao et al (2007, BMC Biotechnology 2007, 7:16 doi:10.1186/1472-6750-7-16 "Engineering proteinase K using machine learning and synthetic genes")] 및 US 특허 8,635,029에 기술된 바와 같은 2개의 상이한 방법을 사용하여 모델링하였다. 회귀 가중치에 대한 평균 값과 표준 편차는 각 치환에 대해 계산하였으며, 이는 표 8에 제시된다. 트랜스포사제 활성에 대한 개별 치환의 효과는 상황에 따라 다를 수 있다(즉, 존재하는 다른 치환). 양의 평균 회귀 가중치는, 평균적으로 테스트된 모든 다른 서열 환경을 고려하여, 치환이 측정된 속성에 긍정적인 영향을 끼친다는 것을 나타낸다. 양의 평균 회귀 가중치를 갖는 치환을 서열에 통합하면 일반적으로 활성이 개선된 변이체를 발생시킨다(Liao et. al., ibid). 이러한 상황에 따른 변동성의 추가 척도는 회귀 가중치의 표준 편차이다. 치환에 대한 평균 회귀 가중치 플러스 회귀 가중치의 표준 편차가 0 이상이면, 치환이 긍정적인 효과를 갖는 상황에 있는 것이다. 치환에 대한 평균 회귀 가중치가 0 이상이면, 모든 측정된 상황에서 치환의 평균 효과는 긍정적이다(Liao et al, ibid). 치환에 대한 평균 회귀 중량 마이너스 회귀 중량의 표준 편차가 0 이상이면, 치환은 대부분의 서열 상황에서 긍정적인 효과를 갖는다(Liao et al, ibid). 다른 활성 피기백-유사 트랜스포사제에서 컨센서스에 대한 변화를 찾음으로써 본 발명자들이 선택한 59개 치환 중 33개는 사용된 방법 중 하나에 의해 결정된 바와 같이 0 이상의 평균 회귀 가중치를 가졌다: D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K, S563K. 유익한 효과를 갖는 특정 치환을 식별하는 것 외에도, 이는 또한 유사한 치환이 유익할 수 있는 위치 표시를 제공한다. 예를 들어, 위치 304에서 산성 아스파르테이트를 염기성 잔기 리신 또는 염기성 잔기 아르기닌으로 교체하면 긍정적인 효과가 있다. 이는 한 위치에서 여러 다양한 유사한 치환이 유익할 수 있다는 증거를 제시한다. 유사한 치환은 아미노산의 특성이 보존되는 치환이다. 예를 들어, 글리신 및 알라닌은 "작은" 아미노산 그룹에 속한다; 발린, 류신, 이소류신 및 메티오닌은 "소수성" 아미노산 그룹에 속한다; 페닐알라닌, 티로신 및 트립토판은 "방향족" 아미노산 그룹에 속한다; 아스파르테이트 및 글루타메이트는 "산성" 아미노산 그룹에 속한다; 아스파라긴 및 글루타민은 "아미드" 아미노산 그룹에 속한다; 히스티딘, 리신 및 아르기닌은 "염기성" 아미노산 그룹에 속한다; 시스테인, 세린 및 트레오닌은 "친핵성" 아미노산 그룹에 속한다. 아마이엘로이스 트랜스포사제 내의 아미노산 위치에서 치환이 절제 또는 전위 활성에 유익한 경우, 동일한 아미노산 그룹으로부터 유래된 동일한 위치에서의 다른 치환이 유익할 가능성이 높다. 예를 들어, 위치 139에서 염기성 잔기 리신의 산성 잔기 글루타메이트로의 대체(K139E)가 유익하기 때문에, 산성 잔기 아스파르테이트로의 대체(즉, K139D) 또한 유익할 가능성이 높다. 유사하게는, 위치 166에서 소수성 잔기 발린의 방향족 잔기 페닐알라닌으로의 대체가 유익하기 때문에, 방향족 잔기 티로신 또는 트립토판으로의 대체(즉, V166Y 또는 V166W) 또한 유익할 가능성이 높다. 유리한 과활성 아마이엘로이스 트랜스포사제는 아미노산 79, 95, 115, 116, 121, 139, 166, 179, 187, 198, 203, 211, 238, 273, 273, 304, 304, 329, 345, 362, 366, 408, 416, 435, 458, 475, 483, 491, 529, 540, 560 및 563으로부터 선택된 하나 이상의 위치에서 아미노산 치환, 예를 들어 D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K, 또는 동일한 위치에서의 유사한 변화로부터 선택된 하나 이상의 치환을 포함한다.
선택된 59개 아미노산 치환 중, 단지 하나(G174A)만이 본질적으로 비활성인 트랜스포사제에서만 배타적으로 발견되었다. 이는, 아마이엘로이스 트랜스포사제 서열을 활성 피기백-유사 트랜스포사제에 대한 컨센서스 서열에 더 가깝게 만드는 아미노산 변화가 전위 및 절제 활성을 유지하는 변이체를 생성하기 위해 아마이엘로이스 트랜스포사제에 통합될 수 있는 치환임을 나타낸다. 표 1 D 열에 변화가 나열되어 있다. 초기 치환 세트로부터의 긍정적인 결과는 표 1의 D 열에서의 다른 변화가 또한 아마이엘로이스 트랜스포사제에 통합되어 이의 활성을 향상시킬 수 있다는 증거를 제공한다.
6.1.6.2 아마이엘로이스 트랜스포사제 변이체의 제2 세트
문헌 [Liao et al (2007, BMC Biotechnology 2007, 7:16 doi:10.1186/1472-6750-7-16 "Engineering proteinase K using machine learning and synthetic genes")] 및 미국 특허 8,635,029, 섹션 5.4.2 및 5.4.3에 기술된 바와 같이, 다른 치환의 상이한 조합의 상황에서 여러 차례 테스트되고, 단백질의 "하나 이상의 활성에 대한 상대적 또는 절대적 기여를 설명하는 양의 회귀 계수, 가중치 또는 기타 값"을 갖는 치환이 일반적으로 단백질에 통합되어 "관심있는 하나 이상의 특성, 활성 또는 기능이 개선된" 단백질을 수득하였다. 표 8에 도시된 치환 가중치를 기반으로 하여, 본 발명자들은 가장 긍정적인 치환(R95S, K139E, V166F, G179N, W187F, P198R, L203R, N211R, D304K, D304R, T345L, T366R, K540R) 중 일부를 조합함으로써 57개의 새로운 변이체(SEQ ID NO: 114-170으로 제공된 서열을 가짐)를 인코딩하는 오픈 리딩 프레임 세트를 설계하였다. 각각의 치환은 57개 변이체 세트 내에서 적어도 10번 나타내었으며, 치환의 다양한 쌍별 조합의 수를 최대화시켜 각 치환이 가능한 많은 다양한 서열 맥락에서 테스트되도록 하였다. 각각의 변이체 오픈 리딩 프레임은 류신 선택가능 마커를 포함하는 벡터 내로 클로닝되었으며; 트랜스포사제 변이체를 인코딩하는 각각의 오픈 리딩 프레임은 사카로마이세스 세레비시애 Gal-1 프로모터에 작동가능하게 연결되었다. 그 후, 이들 변이체 각각은 섹션 6.1.6.1에 기술된 바와 같이 SEQ ID NO: 192의 염색체 통합된 복사체를 포함하는 사카로마이세스 세레비시애 균주 내로 개별적으로 형질전환시켰다. 48시간 후, 세포를 플레이트로부터 스크랩핑하여 탄소원으로서 갈락토스를 가지며 류신이 결여된 최소 배지로 옮겼다. 각 배양에 대한 A600은 2로 조정하였다. 배양물을 갈락토스에서 4시간 동안 성장시켜 트랜스포사제의 발현을 유도한 다음, 5,000x 희석된 분취량을 류신, 우라실 및 트립토판이 결여된 배지에 플레이팅하고(전위를 계수하기 위해), 25,000x 희석된 분취량을 류신이 결여된 배지에 플레이팅하였다(총 생존 세포를 계수하기 위해). 2일 후, 콜로니를 계수하여 전위(= -leu-ura-trp 배지의 세포 수를 (5x -lue 배지의 세포 수)로 나눈 값) 빈도를 결정하였다. 결과는 표 9에 제시된다.
57개의 새로운 아마이엘로이스 트랜스포사제 변이체의 활성 이외에, 표 9는 또한 해당 세트에서 가장 활성인 변이체에 속하는 제1 세트로부터 12개 변이체의 활성을 보여준다. 새로운 변이체 세트 중 절반이 넘는 세트가 제1 세트의 최상의 변이체보다 더 큰 전위 활성을 가졌으며, 모든 새로운 변이체는 자연 발생 아마이엘로이스 트랜스포사제보다 실질적으로 더 많은 전위 활성(50배 초과)을 가졌다. 바람직한 과활성 아마이엘로이스 트랜스포사제는 R95S, K139E, V166F, G179N, W187F, P198R, L203R, N211R, D304K, D304R, T345L, T366R, K540R, 또는 동일한 위치에서의 유사한 변화로부터 선택된 아미노산 치환을 포함한다.
표의 간단한 설명
표 1. 향상된 트랜스포사제 활성을 발생시킬 가능성이 높은 아미노산 변화.
트랜스포사제 활성을 개선할 가능성이 있는 아미노산 치환은 섹션 5.2.6에 설명된 바와 같이 확인되었다. A 열은 아마이엘로이스 트랜스포사제에서의 위치(SEQ ID NO: 18과 비교해)를 보여주며, B 열은 천연 단백질의 아미노산을 보여주며, C 열은 정렬시 등가 위치에서 공지된 활성 피기백-유사 트랜스포사제에서 발견된 아미노산을 보여주며, D 열은 나머지 트랜스포사제 세트 내부에서 우수하게 보존되나, 아마이엘로이스 트랜스포사제 서열의 아미노산이 이상값인 위치에서 아마이엘로이스 트랜스포사제 이외의 공지된 활성 피기백-유사 트랜스포사제에서 발견된 아미노산 변화를 보여준다. 이러한 아미노산에 대한 돌연변이는 특히 향상된 트랜스포사제 활성을 발생시킬 가능성이 높다. 열에 있는 하나 초과의 아미노산 문자는 이러한 개별 아미노산 치환 각각이 허용가능하거나 유익하다는 것을 의미하며, 이는 펩티드를 나타내기 위한 것은 아니다. 예를 들어, 위치 2에서, 아미노산 T, A, R, D 또는 N은 모두 허용가능하여, C 열은 이를 나타내기 위해 "TARDN"을 갖는다.
표 2. 효모에서 트랜스포존의 절제 및 전위.
트랜스포존 및 트랜스포사제 소스는 A 열에 나열되어 있다. B 열에 제시된 SEQ ID NO을 갖는 좌측 서열 및 C 열에 제시된 SEQ ID NO을 갖는 우측 서열을 사용하여 섹션 6.1.2에 기술된 바와 같은 리포터 플라스미드를 작제하였다. 리포터 플라스미드는 D 열에 나열된 SEQ ID NO로 제공된 삽입 서열을 갖는다. 이들 리포터 플라스미드는 사카로마이세스 세레비시애의 Trp-균주의 Ura3 유전자에 통합시켰다. E 열에 제시된 SEQ ID NO로 제공된 아미노산 서열은 사카로마이세스 세레비시애에서 발현가능한 Leu2 유전자 및 2 미크론의 복제 기점을 포함하는 플라스미드 내로 역번역, 합성 및 클로닝하였다. 트랜스포사제 유전자를 Gal1 프로모터에 작동가능하게 연결하였다. 섹션 6.1.1에 기술된 바와 같이 트랜스포사제를 포함하는 플라스미드를 리포터 균주 내로 형질전환시키고, 발현을 유도하고, 세포를 플레이팅하였다. 유도된 배양물을 25,000배 희석한 후 100 μl를 leu 드롭아웃 플레이트에 플레이팅하고, 100배 희석한 후 100 μl를 leu ura 또는 leu ura trp 드롭아웃 플레이트에 플레이팅하였다. F 열은 leu 드롭아웃 플레이트 상의 콜로니 수를 보여준다; G 열은 leu ura 드롭아웃 플레이트 상의 콜로니 수를 보여준다(리포터의 ura 유전자 중간으로부터 트랜스포존의 절제를 나타냄); H 열은 leu ura trp 드롭아웃 플레이트 상의 콜로니 수를 보여준다(리포터의 ura 유전자의 중간으로부터 트랜스포존의 절제 및 게놈의 또 다른 부위로의 전위를 나타냄).
표 3. CHO 표적 세포의 게놈으로의 트랜스포존의 전위.
세포를 섹션 6.1.3에 기술된 바와 같이 트랜스포존 및 트랜스포사제로 형질감염시켰다. 트랜스포존 SEQ ID NO는 1 행에 제시되며, 공동-형질감염된 트랜스포사제 SEQ ID NO는 2 행에 제시된다. 각 형질감염에 있어서, 생존율(생존 가능한 세포의 백분율) 및 총 생존 세포 밀도(ml 당 수백만 개의 세포)가 3 행에 나타난 바와 같이 인접한 열에 제시된다. 4-18 행은 형질감염 후 다양한 시간에서 이러한 측정치를 보여주며, 경과된 날짜는 A 열에 제시된다.
표 4. CHO 표적 세포의 게놈 내에 통합된 트랜스포존으로부터의 항체 생성.
세포를 섹션 6.1.3에 기술된 바와 같이 트랜스포존(SEQ ID NO: 256을 가짐) 및 SEQ ID NO: 18로 제공된 폴리펩티드 서열을 갖는 트랜스포사제를 인코딩하는 DNA로 형질감염시켰다. 회복은 표 3에 제시된다. 14일 유가식 항체 생산 실행 동안, 배양 상청액은 제시된 항체 농도를 함유하였다: A 열은 7일째의 역가를 나타낸다; B 열은 10일째의 역가를 나타낸다; C 열은 12일째의 역가를 나타낸다; D 열은 14일째의 역가를 나타낸다.
표 5. mRNA-인코딩된 트랜스포사제에 의한 CHO 표적 세포의 게놈 내로의 트랜스포존의 전위.
세포를 섹션 6.1.4에 기술된 바와 같이 SEQ ID NO: 18을 갖는 mRNA-인코딩 트랜스포사제 및 SEQ ID NO: 256을 갖는 트랜스포존으로 형질감염시켰다. 생존율(생존 가능한 세포의 백분율) 및 총 생존 세포 밀도(ml 당 수백만 개의 세포)가 1 행에 나타난 바와 같이 각각 B 열 및 C 열에 제시된다. 2-12 행은 형질감염 후 다양한 시간에서 이러한 측정치를 보여주며, 형질감염 이후 경과된 날짜는 A 열에 제시된다.
표 6. CHO 표적 세포의 게놈 내로의 절두된 말단 서열을 갖는 트랜스포존의 전위.
섹션 6.1.5에 설명된 바와 같이 세포를 트랜스포존 및 mRNA-인코딩된 트랜스포사제로 형질감염시켰다. 트랜스포존은 2 행에 제시된 SEQ ID NO을 갖는 좌측 말단 서열에 바로 인접한 SEQ ID NO: 11을 갖는 트랜스포존 ITR 서열에 바로 인접한 5'-TTAA-3' 통합 표적 서열을 포함하는 좌측 트랜스포존 말단을 포함하였다. 트랜스포존은 5'-TTAA-3' 통합 표적 서열에 바로 인접한 SEQ ID NO: 12를 갖는 트랜스포존 ITR 서열에 바로 인접한 3 행에 제시된 SEQ ID NO를 갖는 우측 말단 서열을 포함하는 우측 트랜스포존 말단을 추가로 포함하였다. . 2개의 트랜스포존 말단을 SEQ ID NO: 370을 갖는 글루타민 합성효소 리포터의 양쪽에 배치하였다. 1 행은 표적 서열, ITR, 추가 트랜스포존 말단 서열 및 선택가능 마커를 포함하는 트랜스포존의 SEQ ID NO를 나타낸다. 4 행은 형질감염된 mRNA에 의해 인코딩되는 트랜스포사제의 SEQ ID NO를 나타낸다. 생존율(생존 가능한 세포의 백분율)은 5 행의 "V"로 표지된 열에 나타내고, 총 생존 세포 밀도(ml 당 수백만 개의 세포)는 5 행의 "VCD"로 표지된 열에 나타낸다. 6-15 행은 형질감염 후 다양한 시간에서 이러한 측정치를 보여주며, 형질감염 이후 경과된 날짜는 M 열에 제시된다.
표 7. 아마이엘로이스 트랜스포사제 변이체(제1 세트)의 전위 및 절제 활성.
아마이엘로이스 트랜스포사제 변이체를 인코딩하는 유전자를 섹션 6.1.6.1에 설명된 바와 같이 설계하고, 합성하고, 클로닝하였다. 각 변이체의 SEQ ID NO는 A 열에 제공된다. 유전자는 게놈이 트랜스포사제 리포터 SEQ ID NO: 192의 단일 복사체를 포함하는 사카로마이세스 세레비시애 균주 내로 형질전환시키고, 류신 결여 배지에 플레이팅하였다. 48시간 후, 세포를 플레이트로부터 스크랩핑하여 탄소원으로서 갈락토스를 가지며 류신이 결여된 최소 배지로 옮겼다. 각 배양에 대한 A600은 2로 조정하였다. 트랜스포사제의 발현을 유도하기 위해 배양물을 갈락토스에서 4시간 동안 성장시켰다. 배양물을 류신 결여 최소 배지로 100배 희석하였다; 100 μl 분취량 하나를 류신 및 우라실이 결여된 최소 배지 한천 플레이트에 플레이팅하고(트랜스포존 절제를 측정하기 위해), 또 다른 100 μl 분취량을 류신, 트립토판 및 우라실이 결여된 최소 배지 한천 플레이트에 플레이팅하였다(트랜스포존 전위를 측정하기 위해). 각 배양물을 또한 25,000배 희석하고, 100 μl 분취량을 류신이 결여된 최소 배지 한천 플레이트에 플레이팅하였다(생 세포를 측정하기 위해). 48시간 후, 각 플레이트 상의 콜로니를 계수하고, 류신이 결여된 플레이트 상의 콜로니 수는 B 열에 제시하고, 류신, 우라실 및 트립토판이 결여된 플레이트 상의 콜로니 수를 C 열에 제시하고, 류신 및 우라실이 결여된 플레이트 상의 콜로니 수를 D 열에 제시하였다. E 열은 전위 빈도(C 열의 수를 B 열의 수로 나누고, 추가로 250으로 나눔으로써 계산됨)를 제시하며, F 열은 절제 빈도(D 열의 수를 B 열의 수로 나누고, 추가로 250으로 나눔으로써 계산됨)를 제시한다. G 열의 별표는, 류신 및 우라실이 결여된 플레이트 또는 류신, 트립토판 및 우라실이 결여된 플레이트 상의 콜로니가 너무 조밀하여 정확하게 계산되지 않는 변이체를 나타낸다. 이들 변이체의 재측정은 표 9에 제시된다.
표 8. 아마이엘로이스 트랜스포사제 변이체에서 아미노산 치환에 대한 모델 가중치.
아마이엘로이스 트랜스포사제 절제 및 전위 활성에 대한 서열 변화의 효과는 문헌 [Liao et al (2007, BMC Biotechnology 2007, 7:16 doi:10.1186/1472-6750-7-16 "Engineering proteinase K using machine learning and synthetic genes")] 및 US 특허 8,635,029에 기술된 바와 같이 모델링하였다. 회귀 가중치에 대한 평균 값과 표준 편차는 각 치환에 대해 계산하였다. 위치(SEQ ID NO: 18과 비교해)는 A 열에 제시되고, SEQ ID NO: 18의 이 위치에서 발견되는 아미노산은 열 B에 제시된다. 테스트된 아미노산 치환은 C 열에 제시된다. 로그 데이터 변환을 사용하여 전위 활성에 대한 치환의 회귀 가중치는 D 열에 제시되며, 이러한 회귀 가중치에 대한 표준 편차는 E 열에 제시된다. 로그 데이터 변환을 사용하여 전위 활성에 대한 치환의 회귀 가중치는 F 열에 제시되며, 이러한 회귀 가중치에 대한 표준 편차는 G 열에 제시된다.
표 9. 아마이엘로이스 트랜스포사제 변이체의 전위 활성(제2 세트).
아마이엘로이스 트랜스포사제 변이체를 인코딩하는 유전자를 섹션 6.1.6.2에 설명된 바와 같이 설계하고, 합성하고, 클로닝하였다. 각 변이체의 SEQ ID NO는 A 열에 제공된다. 유전자는 게놈이 트랜스포사제 리포터 SEQ ID NO: 192의 단일 복사체를 포함하는 사카로마이세스 세레비시애 균주 내로 형질전환시키고, 류신 결여 배지에 플레이팅하였다. 48시간 후, 세포를 플레이트로부터 스크랩핑하여 탄소원으로서 갈락토스를 가지며 류신이 결여된 최소 배지로 옮겼다. 각 배양에 대한 A600은 2로 조정하였다. 트랜스포사제의 발현을 유도하기 위해 배양물을 갈락토스에서 4시간 동안 성장시켰다. 배양물을 류신 결여된 최소 배지로 5,000배 희석하고, 하나의 100 μl 분취량을 류신, 트립토판 및 우라실이 결여된 최소 배지 한천 플레이트에 플레이팅하였다(트랜스포존 전위를 측정하기 위해). 각 배양물을 또한 25,000배 희석하고, 100 μl 분취량을 류신이 결여된 최소 배지 한천 플레이트에 플레이팅하였다(생세포를 측정하기 위해). 48시간 후, 각 플레이트 상의 콜로니를 계수하고, 류신이 결여된 플레이트 상의 콜로니 수는 B 열에 제시하고, 류신, 우라실 및 트립토판이 결여된 플레이트 상의 콜로니 수를 C 열에 제시하였다. D 열은 전위 빈도를 보여준다(C 열의 수를 B 열의 수로 나눈 다음 추가로 5로 나눔으로써 계산됨).
표
Figure pct00001
표 1(계속)
Figure pct00002
표 1(계속)
Figure pct00003
표 1(계속)
Figure pct00004
표 1(계속)
Figure pct00005
표 1(계속)
Figure pct00006
표 1(계속)
Figure pct00007
표 1(계속)
Figure pct00008
표 1(계속)
Figure pct00009
표 1(계속)
Figure pct00010
표 1(계속)
Figure pct00011
표 1(계속)
Figure pct00012
표 1(계속)
Figure pct00013
표 2
Figure pct00014
표 3
Figure pct00015
표 4
Figure pct00016
표 5
Figure pct00017
표 6
Figure pct00018
표 7(계속)
Figure pct00019
표 7
Figure pct00020
표 8(계속)
Figure pct00021
표 8
Figure pct00022
표 9(계속)
Figure pct00023
표 9
7. 참고문헌
본원에 인용된 모든 참고 문헌은 마치 각각의 개별 간행물 또는 특허 또는 특허 출원이 모든 목적상 그 전체가 참고로 포함되는 것으로 구체적이고 개별적으로 나타내는 것과 동일한 정도로 모든 목적상 그 전체가 참고로 본원에 포함된다. 인용과 관련된 정보가 시간에 따라 변경될 수 있는 범위까지, 본 출원의 유효 출원일에 유효한 버전을 의미하며, 유효 출원일은 인용이 처음 언급된 출원 또는 우선권 출원의 출원일이다.
본 발명의 많은 수정 및 변형이 본 발명의 사상 및 범위를 벗어나지 않고 이루어질 수 있으며, 이는 당업자에게 명백할 것이다. 본원에 설명된 특정 구체예는 단지 예로서 제공되며, 본 발명은 청구범위에 부여되는 균등물의 전체 범위와 함께 첨부된 청구범위의 조건에 의해서만 제한되어야 한다. 문맥에서 달리 명백하지 않는 한, 임의의 구체예, 양태, 요소, 특징 또는 단계는 임의의 다른 것과 조합하여 사용될 수 있다.
SEQUENCE LISTING <110> DNA TWOPOINTO INC. <120> TRANSPOSITION OF NUCLEIC ACID CONSTRUCTS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM AMYELOIS <130> 062195/546917 <150> 62/831,097 <151> 2019-04-08 <150> 62/873,342 <151> 2019-07-12 <150> 62/990,568 <151> 2020-03-17 <160> 931 <170> PatentIn version 3.5 <210> 1 <211> 319 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 1 ttaacccttg gcatgcctgg tagggtttat tagacccacc actttgaaaa acctatgata 60 tttttttaaa ttgaaggcta ttgttgacgt gtgttatagt agcttcgcgc aataaaccgg 120 cggccatttt gacgagcgaa cttcagtctc acgtgagcgt gcgtgcgagt agcacgtgtg 180 taaagtgcgc gcgggcccgt gggaccctac caggcataca acgtaacatt ctgtcggtaa 240 gaatattttc tttatttttt ggcatttctt tgtttaatgt gttaaattat aatacgaaaa 300 aaatattgtt gcagtagaa 319 <210> 2 <211> 217 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 2 ttaacccttg gcatgcctgg tagggtttat tagacccacc actttgaaaa acctatgata 60 tttttttaaa ttgaaggcta ttgttgacgt gtgttatagt agcttcgcgc aataaaccgg 120 cggccatttt gacgagcgaa cttcagtctc acgtgagcgt gcgtgcgagt agcacgtgtg 180 taaagtgcgc gcgggcccgt gggaccctac caggcat 217 <210> 3 <211> 359 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 3 atcttttcga ttatccaaag ataatagtat tttagttgat ttattagtgc cttaaattaa 60 tgaaagtctg acttcgatct ctgcattata tgtaagattg ttaattatag aactaagagt 120 ttaatttctg ttaattaaaa ttaagcgatt ttgaataatt gttaaataaa gatattttca 180 catacattta catattttat ttattatctg taataataat acattctaaa agacataaat 240 ataaaacaaa attttcctag cttgttcatt tgtgtaaaac atgtattttc aatatcgggt 300 ttgacagacc caccaggcat gccgtgtgat ttttatgtac caggcatgtc aagggttaa 359 <210> 4 <211> 104 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 4 cctagcttgt tcatttgtgt aaaacatgta ttttcaatat cgggtttgac agacccacca 60 ggcatgccgt gtgattttta tgtaccaggc atgtcaaggg ttaa 104 <210> 5 <211> 315 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 5 cccttggcat gcctggtagg gtttattaga cccaccactt tgaaaaacct atgatatttt 60 tttaaattga aggctattgt tgacgtgtgt tatagtagct tcgcgcaata aaccggcggc 120 cattttgacg agcgaacttc agtctcacgt gagcgtgcgt gcgagtagca cgtgtgtaaa 180 gtgcgcgcgg gcccgtggga ccctaccagg catacaacgt aacattctgt cggtaagaat 240 attttcttta ttttttggca tttctttgtt taatgtgtta aattataata cgaaaaaaat 300 attgttgcag tagaa 315 <210> 6 <211> 355 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 6 atcttttcga ttatccaaag ataatagtat tttagttgat ttattagtgc cttaaattaa 60 tgaaagtctg acttcgatct ctgcattata tgtaagattg ttaattatag aactaagagt 120 ttaatttctg ttaattaaaa ttaagcgatt ttgaataatt gttaaataaa gatattttca 180 catacattta catattttat ttattatctg taataataat acattctaaa agacataaat 240 ataaaacaaa attttcctag cttgttcatt tgtgtaaaac atgtattttc aatatcgggt 300 ttgacagacc caccaggcat gccgtgtgat ttttatgtac caggcatgtc aaggg 355 <210> 7 <211> 297 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 7 gggtttatta gacccaccac tttgaaaaac ctatgatatt tttttaaatt gaaggctatt 60 gttgacgtgt gttatagtag cttcgcgcaa taaaccggcg gccattttga cgagcgaact 120 tcagtctcac gtgagcgtgc gtgcgagtag cacgtgtgta aagtgcgcgc gggcccgtgg 180 gaccctacca ggcatacaac gtaacattct gtcggtaaga atattttctt tattttttgg 240 catttctttg tttaatgtgt taaattataa tacgaaaaaa atattgttgc agtagaa 297 <210> 8 <211> 337 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 8 atcttttcga ttatccaaag ataatagtat tttagttgat ttattagtgc cttaaattaa 60 tgaaagtctg acttcgatct ctgcattata tgtaagattg ttaattatag aactaagagt 120 ttaatttctg ttaattaaaa ttaagcgatt ttgaataatt gttaaataaa gatattttca 180 catacattta catattttat ttattatctg taataataat acattctaaa agacataaat 240 ataaaacaaa attttcctag cttgttcatt tgtgtaaaac atgtattttc aatatcgggt 300 ttgacagacc caccaggcat gccgtgtgat ttttatg 337 <210> 9 <211> 18 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 9 cccttgrcat gcctggta 18 <210> 10 <211> 18 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 10 taccaggcat gycaaggg 18 <210> 11 <211> 18 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 11 cccttggcat gcctggta 18 <210> 12 <211> 18 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 12 taccaggcat gtcaaggg 18 <210> 13 <211> 195 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 13 gggtttatta gacccaccac tttgaaaaac ctatgatatt tttttaaatt gaaggctatt 60 gttgacgtgt gttatagtag cttcgcgcaa taaaccggcg gccattttga cgagcgaact 120 tcagtctcac gtgagcgtgc gtgcgagtag cacgtgtgta aagtgcgcgc gggcccgtgg 180 gaccctacca ggcat 195 <210> 14 <211> 112 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 14 gggtttatta gacccaccac tttgaaaaac ctatgatatt tttttaaatt gaaggctatt 60 gttgacgtgt gttatagtag cttcgcgcaa taaaccggac cctaccaggc at 112 <210> 15 <211> 187 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 15 ttgaataatt gttaaataaa gatattttca catacattta catattttat ttattatctg 60 taataataat acattctaaa agacataaat ataaaacaaa attttcctag cttgttcatt 120 tgtgtaaaac atgtattttc aatatcgggt ttgacagacc caccaggcat gccgtgtgat 180 ttttatg 187 <210> 16 <211> 82 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 16 cctagcttgt tcatttgtgt aaaacatgta ttttcaatat cgggtttgac agacccacca 60 ggcatgccgt gtgattttta tg 82 <210> 17 <211> 594 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 17 Met Gly Ser Ser Leu Asp Asp Glu His Ile Leu Ser Ala Leu Leu Gln 1 5 10 15 Ser Asp Asp Glu Leu Val Gly Glu Asp Ser Asp Ser Glu Val Ser Asp 20 25 30 His Val Ser Glu Asp Asp Val Gln Ser Asp Thr Glu Glu Ala Phe Ile 35 40 45 Asp Glu Val His Glu Val Gln Pro Thr Ser Ser Gly Ser Glu Ile Leu 50 55 60 Asp Glu Gln Asn Val Ile Glu Gln Pro Gly Ser Ser Leu Ala Ser Asn 65 70 75 80 Arg Ile Leu Thr Leu Pro Gln Arg Thr Ile Arg Gly Lys Asn Lys His 85 90 95 Cys Trp Ser Thr Ser Lys Ser Thr Arg Arg Ser Arg Val Ser Ala Leu 100 105 110 Asn Ile Val Arg Ser Gln Arg Gly Pro Thr Arg Met Cys Arg Asn Ile 115 120 125 Tyr Asp Pro Leu Leu Cys Phe Lys Leu Phe Phe Thr Asp Glu Ile Ile 130 135 140 Ser Glu Ile Val Lys Trp Thr Asn Ala Glu Ile Ser Leu Lys Arg Arg 145 150 155 160 Glu Ser Met Thr Ser Ala Thr Phe Arg Asp Thr Asn Glu Asp Glu Ile 165 170 175 Tyr Ala Phe Phe Gly Ile Leu Val Met Thr Ala Val Arg Lys Asp Asn 180 185 190 His Met Ser Thr Asp Asp Leu Phe Asp Arg Ser Leu Ser Met Val Tyr 195 200 205 Val Ser Val Met Ser Arg Asp Arg Phe Asp Phe Leu Ile Arg Cys Leu 210 215 220 Arg Met Asp Asp Lys Ser Ile Arg Pro Thr Leu Arg Glu Asn Asp Val 225 230 235 240 Phe Thr Pro Val Arg Lys Ile Trp Asp Leu Phe Ile His Gln Cys Ile 245 250 255 Gln Asn Tyr Thr Pro Gly Ala His Leu Thr Ile Asp Glu Gln Leu Leu 260 265 270 Gly Phe Arg Gly Arg Cys Pro Phe Arg Val Tyr Ile Pro Asn Lys Pro 275 280 285 Ser Lys Tyr Gly Ile Lys Ile Leu Met Met Cys Asp Ser Gly Thr Lys 290 295 300 Tyr Met Ile Asn Gly Met Pro Tyr Leu Gly Arg Gly Thr Gln Thr Asn 305 310 315 320 Gly Val Pro Leu Gly Glu Tyr Tyr Val Lys Glu Leu Ser Lys Pro Val 325 330 335 His Gly Ser Cys Arg Asn Ile Thr Cys Asp Asn Trp Phe Thr Ser Ile 340 345 350 Pro Leu Ala Lys Asn Leu Leu Gln Glu Pro Tyr Lys Leu Thr Ile Val 355 360 365 Gly Thr Val Arg Ser Asn Lys Arg Glu Ile Pro Glu Val Leu Lys Asn 370 375 380 Ser Arg Ser Arg Pro Val Gly Thr Ser Met Phe Cys Phe Asp Gly Pro 385 390 395 400 Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ala Lys Met Val Tyr Leu 405 410 415 Leu Ser Ser Cys Asp Glu Asp Ala Ser Ile Asn Glu Ser Thr Gly Lys 420 425 430 Pro Gln Met Val Met Tyr Tyr Asn Gln Thr Lys Gly Gly Val Asp Thr 435 440 445 Leu Asp Gln Met Cys Ser Val Met Thr Cys Ser Arg Lys Thr Asn Arg 450 455 460 Trp Pro Met Ala Leu Leu Tyr Gly Met Ile Asn Ile Ala Cys Ile Asn 465 470 475 480 Ser Phe Ile Ile Tyr Ser His Asn Val Ser Ser Lys Gly Glu Lys Val 485 490 495 Gln Ser Arg Lys Lys Phe Met Arg Asn Leu Tyr Met Ser Leu Thr Ser 500 505 510 Ser Phe Met Arg Lys Arg Leu Glu Ala Pro Thr Leu Lys Arg Tyr Leu 515 520 525 Arg Asp Asn Ile Ser Asn Ile Leu Pro Lys Glu Val Pro Gly Thr Ser 530 535 540 Asp Asp Ser Thr Glu Glu Pro Val Met Lys Lys Arg Thr Tyr Cys Thr 545 550 555 560 Tyr Cys Pro Ser Lys Ile Arg Arg Lys Ala Asn Ala Ser Cys Lys Lys 565 570 575 Cys Lys Lys Val Ile Cys Arg Glu His Asn Ile Asp Met Cys Gln Ser 580 585 590 Cys Phe <210> 18 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 18 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 19 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 19 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Arg Ser Asn Lys Thr Glu Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Met Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 20 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 20 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Met Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Ser Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Ile Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Lys Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 21 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 21 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asn Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Met Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Arg Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Glu 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 22 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 22 Ser Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Arg Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 23 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 23 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Glu Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Met Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 24 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 24 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Leu Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Lys Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 25 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 25 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asn Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Asn Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 26 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 26 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Pro Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Leu Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Met Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 27 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 27 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Pro Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Lys 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 28 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 28 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Arg Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 29 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 29 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Lys Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 30 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 30 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asn Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Ser Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 31 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 31 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Leu Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Met His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Met Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 32 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 32 Ser Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Pro Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 33 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 33 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe Gln Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Lys 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 34 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 34 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Met Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Arg Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Gly Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 35 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 35 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ser Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Lys 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 36 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 36 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Ala Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Met Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Pro Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Lys Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 37 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 37 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Pro Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Gly Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Ser Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 38 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 38 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Glu Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Ala Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Met Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 39 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 39 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Asn Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Ala Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Glu 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 40 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 40 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Ile Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asp Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Lys 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 41 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 41 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Met Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Arg Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 42 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 42 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Met Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Glu Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Gln Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 43 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 43 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Ala Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Gln Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 44 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 44 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Gly Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Gln 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Gln Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 45 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 45 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Leu Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Ser Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asp Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 46 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 46 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Ala Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asp Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 47 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 47 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Ile Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Ala Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Leu Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 48 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 48 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asp Met Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 49 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 49 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Gln 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Met Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 50 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 50 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Gly Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Cys 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Ser Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 51 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 51 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Ile Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Glu Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Gln 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 52 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 52 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Glu Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Arg Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Ser Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Lys Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 53 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 53 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Leu Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Ala Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Leu Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Gly Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 54 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 54 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Leu Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Met His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Met Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 55 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 55 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Ile Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Lys Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 56 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 56 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe Gln Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Glu Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Ile Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 57 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 57 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Arg Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Leu Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Lys Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 58 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 58 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Asn Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Gln 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 59 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 59 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Ile Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Gln Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 60 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 60 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Glu Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Glu 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ser Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 61 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 61 Ser Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Glu Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Ile Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 62 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 62 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Gln Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ser Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 63 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 63 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Glu Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Leu Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Ile Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 64 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 64 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Leu Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Gly Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 65 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 65 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Asp Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Ser Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ser Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 66 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 66 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asn Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Pro Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Lys His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 67 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 67 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe Gln Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Asn Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Pro Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 68 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 68 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Arg Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Glu Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Lys His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 69 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 69 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Glu Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Cys 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 70 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 70 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Ala Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Cys 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Lys Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 71 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 71 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Cys 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Met His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 72 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 72 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Ser Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Met Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 73 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 73 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Asn Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Ile Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 74 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 74 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Ile Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Ile Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Met Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 75 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 75 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Arg Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Arg Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Glu 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 76 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 76 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Asp Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 77 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 77 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Pro Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Arg Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 78 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 78 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Met Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Met Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 79 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 79 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Leu Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Ile Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Lys Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 80 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 80 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asn Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Gly Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Lys Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 81 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 81 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asp Thr Ala Gly Ile Asn Ala Lys Ile Ile Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 82 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 82 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Ala Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Met Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 83 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 83 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Met His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Lys Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 84 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 84 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Pro Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 85 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 85 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Asp Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 86 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 86 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Arg Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Gln 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Arg Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 87 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 87 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Ile Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Arg Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 88 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 88 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Ala Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Ser Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Lys His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 89 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 89 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Pro Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Gly Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 90 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 90 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Pro Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Ile Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Pro Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 91 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 91 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Glu Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Lys Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 92 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 92 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Cys 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 93 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 93 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Ser Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Met Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 94 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 94 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Pro Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Arg Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Asp Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 95 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 95 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Pro Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Leu Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ser Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 96 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 96 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 97 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 97 Ser Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Gly Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Met Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 98 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 98 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Glu Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Glu 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Met Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 99 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 99 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Gly Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Lys Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 100 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 100 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe Gln Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Arg Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 101 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 101 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Arg Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 102 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 102 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe Gln Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Lys Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 103 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 103 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Leu Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Leu Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 104 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 104 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Ile Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 105 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 105 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Arg Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Ile Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Lys His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 106 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 106 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Arg Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Pro Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 107 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 107 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Glu Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 108 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 108 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Asp Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Met His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 109 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 109 Ser Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Lys Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 110 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 110 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Met Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Lys 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 111 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 111 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Met Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Lys His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 112 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 112 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Ile Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Ile Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 113 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 113 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Lys Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Asp 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Met Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 114 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 114 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 115 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 115 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 116 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 116 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 117 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 117 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 118 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 118 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 119 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 119 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 120 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 120 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 121 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 121 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 122 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 122 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 123 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 123 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Arg Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 124 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 124 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 125 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 125 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 126 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 126 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 127 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 127 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 128 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 128 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 129 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 129 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 130 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 130 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 131 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 131 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 132 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 132 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 133 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 133 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 134 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 134 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 135 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 135 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 136 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 136 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 137 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 137 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 138 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 138 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 139 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 139 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 140 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 140 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 141 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 141 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 142 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 142 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 143 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 143 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 144 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 144 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 145 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 145 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 146 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 146 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 147 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 147 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Phe Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 148 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 148 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 149 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 149 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 150 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 150 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 151 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 151 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 152 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 152 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 153 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 153 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Pro Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 154 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 154 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 155 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 155 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 156 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 156 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 157 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 157 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 158 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 158 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 159 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 159 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 160 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 160 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 161 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 161 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 162 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 162 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Arg Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 163 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 163 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 164 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 164 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 165 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 165 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Lys 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 166 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 166 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 167 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 167 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Leu Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Thr Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 168 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 168 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Val Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Gly Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Leu Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Arg Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 169 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 169 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Leu Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 170 <211> 588 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 170 Met Ala Arg Gly Leu Thr Asp Leu Glu Ile Asn Gln Ile Leu Glu Leu 1 5 10 15 Glu Asp Val Glu Asn Asp Val Ile Phe Asp Glu Ser Gly Asp Glu Ser 20 25 30 Asp His Val Ser Ile Arg Val Glu Ser Asp Thr Glu Glu Val Glu Ile 35 40 45 Pro Thr Leu Glu Pro Gln Gln Gly Ser Ser Asp Ser Glu Asn Asp Gln 50 55 60 Pro Leu Ser Asn Leu Ala Arg Arg Ser Phe Tyr Lys Gly Lys Asp Asn 65 70 75 80 Thr Ile Trp Asn Arg Ala Pro Pro Asn Pro Arg Val Arg Thr Ser Ser 85 90 95 Glu Asn Ile Val Thr Gly Thr Pro Gly Val Lys Arg Gln Ala Lys Asn 100 105 110 Ala Leu Asp Glu Leu Asp Cys Phe His Leu Phe Val Asn Glu Ser Ile 115 120 125 Leu Ser Val Ile Leu Glu His Thr Asn His Glu Ile Arg Ser Glu Arg 130 135 140 Gln Gly Lys Asn Thr Ser Asn Glu Tyr Ala Tyr Ser Glu Thr Thr Leu 145 150 155 160 Thr Glu Leu Arg Ala Phe Ile Gly Leu Leu Tyr Leu Ala Gly Leu Phe 165 170 175 Lys Ser Asn Arg Gln Asn Leu Gln Asp Leu Trp Ala Ser Asp Gly Thr 180 185 190 Gly Ile Glu Ile Phe Arg Met Thr Met Ser Arg Arg Arg Phe Ala Phe 195 200 205 Ile Val Asn Cys Leu Arg Phe Asp Asp Ser Asp Thr Arg Glu Glu Arg 210 215 220 Ala Ala Ile Asp Arg Leu Ala Pro Ile Arg Gln Ile Tyr Glu Glu Phe 225 230 235 240 Val Lys Asn Cys Lys Asp Val Tyr Thr Pro Tyr Glu Asn Leu Thr Ile 245 250 255 Asp Glu Glu Leu Val Ala Phe Arg Gly Arg Cys Lys Phe Arg Gln Tyr 260 265 270 Leu Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Ile Ile Ala Leu Val 275 280 285 Asp Ala Tyr Thr Tyr Tyr Ser Leu Asn Met Glu Ile Tyr Ala Gly Arg 290 295 300 Gln Pro Asp Gly Pro Tyr Lys Val Ser Asn Lys Pro His Asp Val Val 305 310 315 320 Asp Arg Ile Val Gln Pro Ile Ser Gln Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Tyr Pro Thr Tyr Ala His Leu Leu Lys Asn 340 345 350 His Lys Leu Thr Ala Val Gly Thr Met Lys Ser Asn Lys Arg Cys Ile 355 360 365 Pro Pro Lys Phe Arg Glu Arg Arg Glu Ile Asn Thr Ser Leu Phe Gly 370 375 380 Phe Gln Asp Asp Phe Thr Ile Val Ser Tyr Ile Pro Lys Arg Asn Lys 385 390 395 400 Asn Val Phe Met Leu Ser Ser Leu His His Asp Ser Glu Ile Asp Ser 405 410 415 Glu Thr Gly Glu Gln Gln Lys Pro Ser Ile Ile Thr Phe Tyr Asn Lys 420 425 430 Thr Lys Ser Gly Val Asp Asn Val Asp Lys Leu Ile Arg Thr Tyr Asp 435 440 445 Val Ser Arg Asn Ser Arg Arg Trp Pro Leu Thr Ile Phe Phe Trp Ile 450 455 460 Leu Asn Thr Ala Gly Ile Asn Ala Lys Ile Val Gln Met Leu Asn Ser 465 470 475 480 Ser Asp Asn Thr Pro Thr Arg Arg Ala Phe Ile Lys Lys Leu Gly Met 485 490 495 Ser Leu Ile Ala Pro His Gln Ala Glu Arg Lys Thr Asn Ser Lys Ile 500 505 510 Pro Val Ser Leu Arg Lys Arg Ile Gly Ser His Leu Gly Glu Ser Ser 515 520 525 Ala Ser Pro Ala Lys Ile Pro Asn Val Gly Val Lys Lys Arg Cys Tyr 530 535 540 Ile Cys Pro Val Lys Lys Asp Arg Lys Ser Lys Tyr Ile Cys Ile Ser 545 550 555 560 Cys Thr Ser His Ile Cys Leu Glu His Ala Asn Phe Val Cys Glu Asn 565 570 575 Cys Arg Arg Asn Glu Glu Glu Asn Ser Asp Ser Ser 580 585 <210> 171 <211> 1767 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 171 atggctaggg gactgacgga tctggaaatc aaccagatcc tggaactcga ggatgtggag 60 aacgatgtca tcttcgacga gtccggcgat gaatccgacc atgtgtcgat ccgggtggag 120 agcgacaccg aagaggtcga gattccaact ttggaaccgc aacagggtag tagcgattcc 180 gaaaacgatc aacctctctc caacctggcc cggcgcagct tctacaaggg aaaggataac 240 accatctgga accgggctcc ccctaacccc cgcgtccgga ccagatcgga aaacatcgtg 300 accggcactc ctggagtgaa gagacaggcc aagaatgccc tcctcgagct cgactgcttc 360 cacttgtttg tgaacgaatc cattctgtcc gtcatcctcg agcacacgaa ccacaagatc 420 cgctcagagc gacagggaaa gaacacctcc aacgaatacg cttatagcga aaccaccttg 480 actgaactgc gggccgtgat cggacttctg tacctcgcgg gcctgttcaa gagcggacgg 540 cagaatctgc aagacctgtg ggcgtccgac ggtaccggta tcgagatatt cccgatgact 600 atgtcactgc ggcggttcgc cttcatcgtg aactgtctgc ggttcgacga ctccgatacc 660 cgcgaggaaa gggccgcaat cgacaggctg gccccgatta gacagatcta cgaagagttc 720 gtgaagaact gcaaagacgt gtacactcct tacgaaaacc tgaccatcga cgaagaactc 780 gtggcgttcc gcggacgctg caaattcaga cagtacctcc ctaacaagcc cgcgaaatac 840 gggatcaaga tcatcgccct ggtcgatgcg tacacgtact attcattgaa catggaaatc 900 tacgccggcg accagccgga cggcccatac aaagtgtcaa acaagcccca cgatgtggtg 960 gacaggattg tgcagccaat ctcgcaaact ggccggaacg tcaccatgga caattggttc 1020 acatcctacc ccacctacgc ccatcttctg aagaaccaca agctgaccgc cgtggggacc 1080 atgaagtcca acaagacttg catcccgcct aagtttcgcg agcgccgcga gatcaacact 1140 tcccttttcg gattccaaga tgacttcact attgtgtcct acatcccgaa gcgcaacaag 1200 aacgtgttca tgcttagctc cctgcatcac gactcggaaa ttgacagcga aaccggggag 1260 cagcagaagc cttccattat cactttttac aacaagacca agagcggggt ggacaacgtc 1320 gacaagctga ttcggaccta cgacgtgtcc cggaactcca gacgctggcc gctgaccatc 1380 ttcttctgga ttctgaacac tgccggcatc aacgccaaga ttgtgcagat gctgaattcg 1440 tccgataaca cccctacccg gagagctttt atcaagaagc tcggaatgtc actgattgca 1500 ccgcatcagg ccgagagaaa gaccaactcc aagatccccg tgtccctgcg gaagcggatt 1560 ggttcccacc tgggagagtc gagcgccagc ccagcgaaga ttccgaacgt cggcgtcaag 1620 aagcgctgtt acatctgccc cgtgaagaag gaccggaagt cgaagtacat ctgcatttct 1680 tgtacctccc acatctgcct ggaacacgcc aatttcgtgt gcgagaactg caggcgcaac 1740 gaagaagaga actccgacag ctcgtga 1767 <210> 172 <211> 610 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 172 Met Asp Ile Ser Ser Asp Thr Pro Lys Pro Arg Thr Ser Ala Arg Lys 1 5 10 15 Arg Thr Pro Ala Gly Thr Phe Val Ser His Glu Glu Lys Ile Leu Asn 20 25 30 Trp Leu Glu Glu Glu Ser Asp Asp Gly Phe Ser Gly Ile Asp Asp Glu 35 40 45 Asp Gly Asp Pro Ser Phe Glu Pro Glu Ile Gln Arg Asp Glu Asp Asp 50 55 60 Ile Ile Ser Arg Glu Glu Asp Ser Glu Ser Ile Leu Glu Glu Gln Gln 65 70 75 80 Glu Pro Val Val Glu Val Glu Arg Gln Gln Ser Ser Asp Lys Ser Gln 85 90 95 Glu His Tyr Thr Gly Lys Asn Gly Phe Ile Trp Ser Ala Gln Glu Gly 100 105 110 Arg Arg Thr Ser Arg Val Ser Ala His Asn Ile Ile Arg Leu Pro Gly 115 120 125 Arg Ile Ile Thr Lys Lys Phe Glu Gly Tyr Leu Glu Leu Trp Ser Lys 130 135 140 Leu Ile Asp Pro Thr Met Leu Glu Ser Leu Val Arg Tyr Thr Asn Gln 145 150 155 160 Lys Leu Ser Ser Tyr Arg Thr Lys Phe Lys Asn Asn Ser Met Ala Glu 165 170 175 Leu Val Asp Thr Asn Val Asn Glu Met Arg Ala Phe Ile Gly Leu Met 180 185 190 Tyr Tyr Ser Ser Val Phe Lys Cys Asn Asp Glu Asn Ile Asn Thr Ile 195 200 205 Phe Ala Thr Asn Gly Thr Gly Arg Glu Ile Phe Arg Cys Val Met Ser 210 215 220 Lys Leu Arg Phe Ser Cys Leu Ile Asn Cys Leu Arg Phe Asp Asp Ser 225 230 235 240 Ile Thr Arg Gln Glu Arg Leu Lys Asp Asp Thr Leu Ala Pro Ile Ser 245 250 255 Glu Ile Phe Asp Lys Phe Ile Ser Asn Ser Gln Ser Glu Tyr Thr Pro 260 265 270 Gly Ala Tyr Leu Cys Ile Asp Glu Met Leu Val Pro Phe Arg Gly Arg 275 280 285 Cys Lys Phe Ile Ile Tyr Met Pro Gln Lys Pro Ala Lys Tyr Gly Ile 290 295 300 Lys Ile Leu Leu Leu Val Asp Ala Arg Thr Tyr Tyr Ile Tyr Asn Ala 305 310 315 320 Tyr Ile Tyr His Gly Lys Tyr Ser Asp Gly Lys Gly Leu Thr Asp Gln 325 330 335 Glu Lys Lys Met Ala Val Pro Thr Gln Ser Val Leu Arg Leu Ala Lys 340 345 350 Val Val Glu Asn Ser Asn Arg Asn Ile Thr Ala Asp Asn Trp Phe Ser 355 360 365 Ser Ile Pro Leu Val Glu Ile Leu Leu Lys Arg Gly Leu Thr Tyr Leu 370 375 380 Gly Thr Leu Lys Lys Asn Lys Ala Glu Ile Pro Pro Cys Phe Leu Pro 385 390 395 400 Asn Lys Asn Arg Leu Ala Glu Ser Ser Leu Tyr Gly Phe Thr Lys Asp 405 410 415 Tyr Thr Leu Leu Ser Tyr Val Pro Lys Pro Asn Lys Ala Val Leu Leu 420 425 430 Ile Ser Ser Ser His His Ile Gln Glu Ile Asp Lys Asp Thr Gly Lys 435 440 445 Pro Ile Met Ile Ala Asp Tyr Asn Ser Thr Lys Gly Gly Val Asp Glu 450 455 460 Val Asp Lys Lys Cys Ser Ile Tyr Cys Cys Ser Arg Lys Thr Arg Arg 465 470 475 480 Trp Pro Met Ala Ile Phe Gln Arg Ile Leu Asp Met Ala Gly Ile Asn 485 490 495 Ser Phe Val Leu Tyr Gln Ser Cys Asp Asp Ser Asp Gly Lys Met Arg 500 505 510 Arg Gly Thr Phe Leu Leu Asn Met Ala Arg Asp Leu Val Leu Asp His 515 520 525 Met Lys Asn Arg Val Tyr Asn Glu Arg Leu Pro Arg Glu Leu Arg Met 530 535 540 Thr Leu Thr Arg Val Leu Gly Lys Asp Thr Pro Pro Ser Pro Pro Val 545 550 555 560 Ala Arg Ser Val Pro Pro Ser Gly Lys Lys Leu Cys Tyr Ile Cys Pro 565 570 575 Thr Lys Ile Lys Arg Gln Thr Lys Tyr Arg Cys Cys Asp Cys Ser Lys 580 585 590 Pro Ile Cys Leu Gln Cys Ser Lys Pro Leu Cys Asp Asn Cys Gln Thr 595 600 605 Lys Leu 610 <210> 173 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 173 Met Pro Arg Gly Leu Lys Asp Ser Glu Ile Ile Gln Phe Leu Glu Glu 1 5 10 15 Glu Glu Glu Ala Ile Asp Ser Ala Ser Glu Asn Glu Gln Asp His Asp 20 25 30 Val Ile Val Ser Asp His Val Thr Glu Ser Glu Gln Ser Glu Asn Glu 35 40 45 Ser Asn Asp Gln Trp Arg Ser Glu Asp Glu Val Pro Leu Gln Asn Leu 50 55 60 Ala Ser Ser Ser Gln Ser His Asp Gln Ser Phe Tyr Leu Gly Lys Asn 65 70 75 80 Arg Leu Thr Lys Trp Tyr Lys His Pro Pro Arg Ser Met Val Arg Thr 85 90 95 Gln Arg Ser Asn Ile Val Thr Glu Thr Ala Gly Pro Lys Gly Pro Ala 100 105 110 Arg Asp Ile Met Thr Leu Ser Asp Ala Phe Leu Ser Ile Phe Ser Arg 115 120 125 Glu Thr Val Asp Leu Ile Leu Thr Tyr Thr Asn Glu Tyr Ile Ile Ser 130 135 140 Ile Gln Asn Asn Phe Gln Arg Glu Arg Asp Cys Lys Val Val Ser Tyr 145 150 155 160 Glu Glu Leu Leu Ala Phe Phe Gly Leu Leu Tyr Met Ser Gly Val Leu 165 170 175 Arg Ser Ser His Leu Asn Tyr Gln Asp Leu Trp Ala Ala Asp Gly Thr 180 185 190 Gly Ile Glu Phe Phe Ser Asn Thr Met Ser Cys Lys Arg Phe Leu Phe 195 200 205 Ile Leu Arg Ser Leu Arg Phe Asp Ser Arg Thr Thr Arg Glu Val Arg 210 215 220 Gln Ser Leu Asp Lys Leu Ala Ala Ile Arg Asp Phe Cys Asn Leu Met 225 230 235 240 Asn Asp Asn Phe Gln Lys Cys Tyr Ser Met Ser Glu Asn Val Thr Ile 245 250 255 Asp Glu Gln Leu Pro Ala Phe Arg Gly Arg Phe Cys Gly Val Val Tyr 260 265 270 Met Pro Ser Lys Pro Thr Lys Tyr Gly Ile Lys His Phe Ala Leu Val 275 280 285 Asp Ser Ala Thr Tyr Tyr Leu Gln Arg Phe Glu Val Tyr Val Gly Val 290 295 300 Gln Pro Asp Gly Pro Phe Lys Leu Pro Ser Asp Thr Lys Ser Leu Val 305 310 315 320 Lys Arg Leu Ile Glu Pro Ile Ser Gly Thr Gly Arg Asn Val Thr Met 325 330 335 Asp Asn Trp Phe Thr Ser Val Pro Leu Ala Lys Ser Leu Leu Asp Glu 340 345 350 His Thr Leu Thr Met Val Gly Thr Leu Arg Lys Asn Lys Pro Glu Ile 355 360 365 Pro Lys Cys Phe Leu Pro Glu Lys Lys Arg Glu Thr Thr Ser Ser Ile 370 375 380 Phe Gly Phe Gln Lys Asp Met Thr Leu Cys Ser Tyr Val Pro Lys Pro 385 390 395 400 Arg Lys Ala Val Met Leu Leu Ser Thr Met His His Asp Asp Asn Val 405 410 415 Glu Gly Glu Lys Arg Lys Pro Glu Ile Ile His Phe Tyr Asn Lys Thr 420 425 430 Lys Gly Gly Val Asp Thr Asn Asp Gln Met Cys Ala Thr Tyr Asn Val 435 440 445 Gly Arg Arg Thr Lys Arg Trp Pro Met Val Ile Phe Phe His Ile Phe 450 455 460 Asn Ile Thr Gly Ile Asn Ser Tyr Val Ile Tyr Lys Ser Lys Ile Asp 465 470 475 480 Ser Asn Ile Ser Arg Arg Leu Phe Leu Lys Leu Leu Ala Val Asp Leu 485 490 495 Val Lys Pro His Gln Met Ser Arg Ala Ser Ile Pro Thr Leu Pro Arg 500 505 510 Pro Leu Gln Lys Arg Leu Lys Arg Gln His Glu Ile Gln Asp Gln Val 515 520 525 Ser Ile Pro Glu Ala Gly Arg Ser Gln Ser Tyr Lys Arg Cys His Val 530 535 540 Cys Pro Arg Ser Lys Asp Arg Lys Thr Lys Thr Glu Cys Phe Lys Cys 545 550 555 560 His Lys His Val Cys Asn Asp His Met Asn Ile Val Cys Lys Asn Cys 565 570 575 Asn Asp <210> 174 <211> 563 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 174 Met Ala Ser Ile Leu Thr Asp Glu Glu Ile Leu Ser Met Ile Asn Asn 1 5 10 15 Gly Asp Phe Leu Leu Ser Asp Glu Asp Phe Gly Leu Asn Ser Gly Ser 20 25 30 Asp Ser Leu Gly Glu Gly Asp Ser Ala Asp Asp Asp Cys Asp Gln Asn 35 40 45 Asn Ile Val Glu Gln Asn Ile Ala Asn Gln Ser Pro Ala Ser Leu Thr 50 55 60 Glu Thr Asp Leu Ala Ser Pro Gln Ile Ser Arg Glu Asn Asn Tyr Asn 65 70 75 80 Trp Ser Thr Cys Arg Pro Gln Val Ile Asp Ile Pro Phe Ser Glu Thr 85 90 95 Pro Gly Leu Lys Ile Phe Pro Lys Gly Asn Asp Pro Ile Asp Tyr Phe 100 105 110 Asn Leu Phe Val Thr Asn Thr Phe Trp Glu Phe Leu Val Glu Glu Ala 115 120 125 Asn Ser Tyr Ala Val Glu Val Phe Leu Asn Ser Asp Arg Ser Asn Ser 130 135 140 Arg Ile Ser Thr Trp Lys Asn Thr Asp Val Val Glu Met Lys Lys Phe 145 150 155 160 Ile Ala Leu Leu Phe His Thr Gly Thr Ile Arg Val Asn Arg Leu Glu 165 170 175 Asp Tyr Trp Lys Thr Asn Glu Leu Phe Asn Phe His Ile Phe Arg Ser 180 185 190 Thr Met Ser Arg Asn Arg Phe Met Leu Leu Leu Arg Val Leu His Phe 195 200 205 Cys Lys Asn Pro Gly Gln Asn Asp Asn Pro Thr Ser Arg Leu His Lys 210 215 220 Ile Asp Lys Met Thr Asn Tyr Phe Asn Lys Thr Met Glu Glu Leu Tyr 225 230 235 240 Gln Pro Ser Lys Asn Leu Ser Ile Asp Glu Ser Met Val Leu Phe Arg 245 250 255 Gly Arg Leu Met Phe Arg Gln Tyr Ile Lys Asn Lys Arg His Lys Tyr 260 265 270 Gly Ile Lys Leu Tyr Met Met Thr Glu Ser Trp Gly Leu Val His Arg 275 280 285 Val Leu Ile Tyr Ser Gly Glu Gly Thr Gly Thr Ser Glu Glu Leu Ser 290 295 300 His Thr Glu Tyr Val Val Glu Lys Leu Met Glu Gly Tyr Tyr Tyr Lys 305 310 315 320 Gly His Ser Ile Tyr Met Asp Asn Tyr Tyr Asn Ser Val Lys Leu Ala 325 330 335 His Tyr Leu Leu Glu Lys Gln Thr Tyr Cys Thr Gly Thr Leu Arg Ala 340 345 350 Asn Arg Lys Asn Asn Pro Lys Ala Ile Asn Asp Lys Lys Leu Lys Lys 355 360 365 Gly Glu Thr Ile Cys Gln Tyr Thr Glu Lys Gly Val Gly Val Val Lys 370 375 380 Trp Lys Asp Arg Arg Asp Val Ile Ala Ile Ser Ser Glu His Ser His 385 390 395 400 Asp Leu Val Asn Ile Thr Asn Arg Lys Gly Ile Ile Lys Ser Lys Pro 405 410 415 Leu Ser Ile Ile Lys Tyr Asn Glu Tyr Met Ser Gly Ile Asp Arg Gln 420 425 430 Asp Gln Met Leu Ser Tyr Tyr Pro Cys Glu Arg Lys Thr Leu Arg Trp 435 440 445 Tyr Lys Lys Leu Gly Ile His Phe Ile Gln Ile Leu Leu Leu Asn Ser 450 455 460 Tyr Leu Leu Tyr Asn Lys Asn Val Lys Lys Ile Ser Phe Tyr Asp Tyr 465 470 475 480 Arg Leu Lys Ile Ile Ser Thr Ile Leu Asn Ser Gly Glu Asn Asn Ile 485 490 495 Thr Lys Arg Gln Pro Thr Asn Asn Asn Ala Leu His Phe Ser Lys Lys 500 505 510 Val Pro Lys Asn Lys Asn Asn Lys Ile Met Tyr Lys Arg Cys Lys Leu 515 520 525 Cys Ser Ser Lys Gly Val Arg Lys Met Thr Ser Phe Tyr Cys Ser Met 530 535 540 Cys Glu Asp Glu Pro Gly Phe Cys Leu Asp Cys Phe Glu Glu Phe His 545 550 555 560 Arg Ser Ile <210> 175 <211> 592 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 175 Met Ile Met Ser Asn Arg Lys Thr Val Arg Ala Thr Asp Pro Asn Phe 1 5 10 15 Glu Ser Gln Val Met Ala Trp Phe Glu Glu Ser Asn Glu Glu Leu Ser 20 25 30 Ile Asp Gln Gly Asp Ser Asp Glu Lys Gln Trp Pro Asp Glu Asn Glu 35 40 45 Asn Asp Val Ile Glu Asn His His Thr Ser Glu Glu Glu Glu Glu Glu 50 55 60 Glu Glu Glu Glu Gly Glu Asp Phe Asp Lys Glu Asn Glu Glu Gln Pro 65 70 75 80 Asn Gln Asn Tyr Phe Tyr Gly Lys Asn Lys Ile Thr Arg Trp Asn Lys 85 90 95 Asn Cys Pro Val Asn Ser Arg Thr Arg Ser His Asn Ile Val Lys Ile 100 105 110 Arg Val Pro Gly Pro Gln Ser Ser Ala Lys Asn Cys Lys Thr Gln Leu 115 120 125 Glu Thr Leu Arg Cys Phe Leu Asp Glu Glu Ile Ile Thr Leu Ile Val 130 135 140 Lys Tyr Thr Asn Ile Tyr Ile Asn Glu Val Lys Asp Lys Tyr Ser Arg 145 150 155 160 Ala Arg Asp Ala Lys Leu Thr Asn Asn Glu Glu Val Leu Gly Leu Ile 165 170 175 Gly Ile Leu Tyr Leu Ala Gly Leu Leu Gln Ser Gly Arg Gln His Ile 180 185 190 Leu Gln Met Trp Asp Asn Ser Lys Gly Leu Gly Val Glu Ala Ile Tyr 195 200 205 Leu Thr Met Gly Ile Asn Arg Phe Arg Phe Leu Met Arg Cys Leu Arg 210 215 220 Phe Asp Asn Ile Ile Asp Arg Asn Glu Arg Lys Lys Thr Asp Asn Leu 225 230 235 240 Ala Ala Ile Arg Lys Ile Phe Glu Met Phe Val Leu Lys Phe Lys Ser 245 250 255 Met Phe Ile Pro Ser Gln Tyr Leu Thr Leu Asp Glu Gln Leu Ile Ala 260 265 270 Phe Arg Gly Asn Cys Pro Phe Arg Thr Tyr Ile Pro Ser Lys Pro Ala 275 280 285 Lys Tyr Gly Ile Lys Ile Phe Ala Leu Val Asp Cys Lys Ser Ile Tyr 290 295 300 Thr Cys Asn Leu Glu Ile Tyr Cys Gly Lys Gln Pro Ala Gly Pro His 305 310 315 320 Ser Thr Ser Trp Lys Asn Tyr Asp Leu Val Met Arg Met Ile Ala His 325 330 335 Ile Thr Gly Thr Gly Arg Asn Val Ser Met Asp Asn Trp Phe Thr Ser 340 345 350 Val Pro Leu Ala Val Asp Leu Leu Gln Met Lys Thr Thr Ile Ile Gly 355 360 365 Thr Leu Arg Lys Asn Lys Pro Asp Ile Pro Pro Gln Phe Ile Asn Ala 370 375 380 Thr His Arg Glu Val Tyr Ser Ser Leu Phe Gly Phe His Lys Met Cys 385 390 395 400 Thr Leu Val Ser Tyr Val Pro Lys Arg Lys Lys Val Val Leu Leu Leu 405 410 415 Ser Thr Met His His Asp Cys Ala Ile Asp Asn Asp Thr Gly Asp Leu 420 425 430 Lys Lys Pro Glu Ile Ile Thr Asp Tyr Asn Asn Thr Asn Tyr Gly Val 435 440 445 Asp Met Leu Asp Lys Met Cys Ser His Tyr Asp Val Ser Arg Asn Ser 450 455 460 Arg Arg Trp Pro Leu Thr Ile Phe Phe Asn Leu Leu Asn Ile Ala Ala 465 470 475 480 Ile Asn Gly Met Cys Ile Tyr Lys Thr Lys Ser Ile Asn Lys Ile Asp 485 490 495 Arg Lys Ser Asp Leu Gln Thr Ile Gly Tyr Glu Leu Ile Thr Pro Leu 500 505 510 Leu Arg Lys Arg Leu Glu Ser Asp Asn Ile Ala Thr Asn Ile Lys Glu 515 520 525 His Ile Arg Lys Leu Leu Asn Ile Glu Pro Glu Ile Leu Ala Glu Ile 530 535 540 Gln Pro Asn Thr Ser Thr Val Gly Lys Cys Phe Tyr Cys Gly Arg Gln 545 550 555 560 Lys Asn Lys Ser Thr Arg Lys His Cys Ser Lys Cys Gly Lys Trp Val 565 570 575 Cys Pro Ala His Leu Arg His Ile Cys Pro Lys Cys Asn Glu Glu Asp 580 585 590 <210> 176 <211> 565 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 176 Met Ala Gly Gln Tyr Asn Leu Arg Pro Ile Ser Ala Leu Ala Glu Thr 1 5 10 15 Leu Arg Ala Thr Glu Arg Glu Gln Ala Ser Asp Ile Pro Ser Glu Glu 20 25 30 Glu Asp His Ala Val Glu Phe Ser Gly Ser Glu Ser Glu Glu Asp Ala 35 40 45 Asp Glu Ile Ser Glu Gln Pro Asp Glu Gly Asn Ser Arg Lys Arg Ser 50 55 60 Asn Pro Ser Ile Ile His Gly Lys Asp Gly His Arg Trp Tyr Thr Thr 65 70 75 80 Pro Gln Gln Arg Ser Gln Gly Arg Gln Asn Thr Pro Val Ser Tyr Leu 85 90 95 Pro Gly Pro Val Gly Glu Ala Arg Arg Ala Ser Thr Pro Leu Gln Met 100 105 110 Trp Ser Leu Leu Phe Pro Asp Ser Leu Ile Glu Lys Ile Val Arg His 115 120 125 Thr Asn Glu Glu Ile Arg Arg Tyr Arg Asp Ser Leu Glu Ile Asp Asp 130 135 140 Asp Arg Asp Arg Thr Tyr Ser Glu Val Gly Ile Val Glu Ile Lys Ala 145 150 155 160 Tyr Ile Gly Leu Leu Tyr Phe Ser Gly Leu Gln Lys Thr Ser His Thr 165 170 175 Asn Leu Glu Asp Leu Trp Asn Pro Glu Tyr Gly Ser Ile Met Tyr Arg 180 185 190 Ser Thr Met Ser Cys Asn Arg Phe Ser Val Ile Ser Arg Asn Leu Arg 195 200 205 Phe Asp Asp Lys Thr Thr Arg Ala Glu Arg Arg Glu Thr Asp Lys Phe 210 215 220 Ala Pro Ile Arg Glu Leu Trp Glu Gln Phe Ile Ser Asn Cys Thr Lys 225 230 235 240 Tyr Tyr Asn Pro Thr Ser Tyr Cys Thr Ile Asp Glu Gln Leu Val Ser 245 250 255 Phe Arg Gly Arg Cys Pro Phe Lys Val Tyr Asn Gly Ala Lys Pro Asp 260 265 270 Lys Tyr Gly Ile Lys Ile Val Met Leu Asn Asp Ser Arg Thr Phe Tyr 275 280 285 Met Phe Ser Ala Glu Pro Tyr Val Gly Arg Val Thr Thr Glu Lys Gly 290 295 300 Glu Ser Val Pro Ser Tyr Tyr Ile Arg Lys Leu Ser Gln Pro Leu His 305 310 315 320 Gly Thr Lys Arg Asn Ile Thr Cys Asp Asn Trp Phe Ser Ser Ile Pro 325 330 335 Ile Phe Glu Lys Met Leu Thr Glu His Ser Ile Thr Met Val Gly Thr 340 345 350 Leu Arg Lys Asn Lys Arg Glu Ile Pro Gly His Phe Arg Ser Ala Gly 355 360 365 Pro Val Ser Ser Ser Lys Phe Ala Phe Asp Gly Arg Met Thr Leu Met 370 375 380 Ala His Thr Pro Lys Gln Asn Lys Ile Val Ile Leu Leu Ser Thr Phe 385 390 395 400 His Asp Cys Ala Thr Ile Asn Gln Glu Thr Gln Lys Met Glu Ile Ile 405 410 415 His Phe Tyr Asn Thr Thr Lys Gly Gly Thr Asp Ser Phe Asp Gln Met 420 425 430 Cys His Glu Tyr Ser Thr Ala Arg Lys Thr Leu Arg Trp Pro Met Arg 435 440 445 Ile Trp Leu Ala Met Leu Asp Gln Gly Gly Ile Asn Ala Leu Ile Leu 450 455 460 Tyr Asn Ser Asn Ala Asn Leu Glu Ala Phe Asn Arg Lys Thr Phe Leu 465 470 475 480 Lys Asn Leu Ile Lys Ala Leu Val Glu Pro His Leu Arg Ala Arg Leu 485 490 495 Gln Leu Pro Asn Phe Arg Arg Glu Leu Arg Phe Asn Ile His Thr Ile 500 505 510 Leu Gly Gln Gly Glu Arg Pro Val Lys Arg Gly Gln Gln Lys Arg Ala 515 520 525 Arg Cys Gly Leu Cys Pro Arg Ala Gln Asp Arg Lys Val Gln Met Tyr 530 535 540 Cys Glu Met Cys His Arg Thr Val Cys Glu Asp His Arg Val Ile Phe 545 550 555 560 Cys Cys Asp Cys Ala 565 <210> 177 <211> 587 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 177 Met Glu Asp Ala Lys Lys Arg Lys Leu Thr Ser Asp Asp Pro Ser Val 1 5 10 15 Trp Leu Lys Trp Phe Glu Glu Met Ser Glu Glu Glu Asn Glu Lys Asp 20 25 30 Glu Glu Ser Cys Ser Glu Ile Glu Ala Asp Ile Leu Glu Glu Ser Pro 35 40 45 His Asp Thr Ala Ser Glu Gln Glu Ala Gly Asp Leu Glu Ser Asp Asn 50 55 60 Asp Cys Asp Asp Ile Ser Asp Ser Glu Ser Glu Asn Phe Tyr Ile Gly 65 70 75 80 Lys Asp Lys Phe Thr Lys Trp Cys Lys Val Lys Pro Arg Gln Asn Val 85 90 95 Arg Thr Arg Ser Cys Asn Ile Ile Ile His Leu Pro Gly Pro Arg Arg 100 105 110 Glu Ala His Gly Val Gln Lys Glu Ile Asp Ile Leu Lys Phe Phe Leu 115 120 125 Asp Asp Asn Val Phe Arg Met Ile Val Ala Ser Thr Asn Ile Lys Ile 130 135 140 Gly Val Val Arg Glu Lys Tyr Cys Arg Ala Arg Asp Ala Ala Asp Thr 145 150 155 160 Asp Val Thr Glu Ile Cys Ala Phe Ile Gly Leu Leu Tyr Leu Ile Gly 165 170 175 Ser Leu Arg Cys Ser Arg Lys Asn Met His Asp Leu Trp Asp Asn Ser 180 185 190 Arg Gly Asn Gly Leu Glu Ser Cys Tyr Leu Thr Met Ser Glu Asn Arg 195 200 205 Phe Lys Phe Leu Leu Arg Cys Leu Arg Phe Asp Asp Ile Arg Asp Arg 210 215 220 His Met Arg Lys Glu Val Asp Lys Leu Cys Ser Ile Arg Asp Leu His 225 230 235 240 Glu Leu Leu Ile Asn Asn Phe Gln Arg Tyr Phe Cys Ala Ser Glu Tyr 245 250 255 Leu Thr Val Asp Glu Gln Leu Leu Ala Phe Arg Gly Asn Cys Ser Phe 260 265 270 Arg Gln Tyr Ile Pro Ser Lys Pro Ala Lys Tyr Gly Leu Lys Ile Phe 275 280 285 Ala Leu Val Asp Cys Lys Thr Gly Tyr Thr Ile Asn Leu Glu Pro Tyr 290 295 300 Val Gly Lys Gln Pro Glu Gly Pro Tyr Gln Val Gly Asn Ser Gly Glu 305 310 315 320 Glu Ile Val Leu Arg Leu Cys Asn Pro Val Glu Gly Thr Asn Arg Asn 325 330 335 Ile Thr Ala Asp Asn Trp Phe Thr Ser Val Thr Val Ser Glu Arg Leu 340 345 350 Leu Leu Glu Lys Lys Leu Thr Tyr Val Gly Thr Met Arg Lys Asn Lys 355 360 365 Arg Glu Ile Pro Lys Glu Phe Leu Pro Asn Lys Ser Ile Pro Ala Lys 370 375 380 Ser Ser Ile Phe Gly Phe Gly Lys Asn Ser Thr Leu Val Ser Tyr Cys 385 390 395 400 Leu Lys Lys Gly Lys Ser Val Ile Leu Leu Ser Ser Met His Phe Asp 405 410 415 Asp Thr Ile Asp Val Ser Thr Gly Asp His Lys Lys Pro Glu Ile Val 420 425 430 Thr Phe Tyr Asn Met Thr Lys Val Gly Val Asp Leu Val Asp Gln Leu 435 440 445 Cys Gln Lys Tyr Asp Val Ser Arg Asn Thr Arg Arg Trp Pro Leu Val 450 455 460 Met Phe Tyr Asn Leu Leu Asn Ile Ser Ala Ile Asn Ala Phe Val Ile 465 470 475 480 Tyr Lys Ala Asn Thr Arg Glu Ser Thr Gln Ile Gln Arg Arg Ile Phe 485 490 495 Leu Gln Asn Ile Ser Trp Glu Leu Ile Lys Pro Gln Ile Glu Arg Arg 500 505 510 Thr Ala Val Leu Thr Ile Pro Lys Glu Ile Arg Arg Arg Ala Arg Val 515 520 525 Leu Leu Gly Ile Glu Glu Ser Thr Val Pro Gln Lys Arg Pro Gly Thr 530 535 540 Arg Gly Arg Cys Leu Pro Cys Gly Arg Gln Arg Asn Lys Thr Thr Arg 545 550 555 560 Arg Trp Cys Cys Lys Cys Gln Ile Trp Ala Cys Gly Glu His Leu Thr 565 570 575 Asp Ile Cys Leu Gln Cys Leu Glu Asn Thr Asn 580 585 <210> 178 <211> 564 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 178 Met Thr Arg Tyr Met Asn Tyr Asp Glu Glu Asn Glu Tyr Phe Arg His 1 5 10 15 Leu Ile Glu Thr Val Ser Ser Asp Asp Glu Ala Ile Ser Asp Glu Ser 20 25 30 Val Ala Ser Glu Asp Asp Glu Tyr Cys Ser Asn His Asp Ser Ser Ser 35 40 45 Glu Ile Glu Thr Glu Thr Glu Asp Glu Ser Ser Leu Ser Ala Thr Asp 50 55 60 Phe Tyr Ile Gly Lys Asp Lys Val Thr Lys Trp Leu Lys Lys Lys Tyr 65 70 75 80 Ser Gln Ser Val Arg Lys Pro Ala Arg Asn Ile Ile Ser Lys Leu Pro 85 90 95 Gly Asn Thr Ala Tyr Ser Lys His Val Ala Ser Pro Val Asp Ala Trp 100 105 110 Asn Val Leu Phe Asp Ser Lys Met Leu Asn Met Met Val Glu Asn Thr 115 120 125 Asn Ile Tyr Ile Glu Ser Ile Gln Glu Arg Phe Thr Arg Glu Arg Asp 130 135 140 Ala Arg Lys Thr Asp Glu Thr Glu Ile Lys Ala Phe Ile Gly Leu Leu 145 150 155 160 Tyr Leu Cys Gly Thr His Lys Ser Ser His Thr Asn Leu Lys Asp Leu 165 170 175 Tyr Ala Thr Asp Gly Thr Gly Ile Asp Ile Phe Pro Lys Thr Met Ser 180 185 190 Arg Thr Arg Phe Leu Phe Leu Met Arg Cys Leu Arg Phe Asp Asn Ile 195 200 205 Asn Asp Arg Gln Ser Arg Arg Glu Ile Asp Lys Leu Ala Pro Ile Arg 210 215 220 Asp Phe Phe Glu Thr Phe Val Thr Asn Cys Lys Asn Ala Tyr Thr Leu 225 230 235 240 Gly Glu Phe Val Thr Ile Asp Glu Lys Leu Glu Pro Phe Arg Gly Arg 245 250 255 Cys Gly Phe Arg Gln Tyr Met Pro Lys Lys Pro Ala Lys Tyr Gly Ile 260 265 270 Lys Ile Phe Ala Leu Val Asp Ser Arg Val Phe Tyr Thr Trp Asn Met 275 280 285 Glu Ile Tyr Ala Gly Gln Gln Pro Asp Gly Pro Phe Lys Ile Asp Cys 290 295 300 Ser Ser Lys Ser Ile Val Met Arg Leu Met Thr Pro Leu Phe Asn Ser 305 310 315 320 Gly Arg Asn Leu Thr Thr Asp Asn Trp Tyr Thr Gly Tyr Glu Leu Ala 325 330 335 Gln Glu Leu Leu Lys Lys Lys Ile Thr Ile Val Gly Thr Leu Arg Gln 340 345 350 Asn Lys Arg Glu Ile Pro Pro Gln Phe Leu Val Lys Lys Glu Leu Tyr 355 360 365 Ser Ser Ile Phe Gly Phe Gln Lys Glu Thr Thr Met Val Ser Tyr Ser 370 375 380 Ala Lys Lys Asn Lys Asn Val Val Met Leu Ser Thr Met His Thr Asp 385 390 395 400 Asp Lys Ile Asp Glu Thr Thr Met Glu Leu Lys Lys Pro Asp Ile Ile 405 410 415 Thr Phe Tyr Asn Leu Thr Lys Gly Ala Val Asp Val Val Asp Glu Met 420 425 430 Ala Ala Ala Tyr Thr Thr Ala Arg Ile Ser Asn Arg Trp Pro Met Val 435 440 445 Ile Leu Phe Ser Met Leu Asn Val Ala Ala Ile Asn Ala Arg Val Leu 450 455 460 Leu Met Ser Thr Lys Asn Pro Pro Thr Gln Phe Arg Asn Arg Arg Phe 465 470 475 480 Phe Leu Lys Thr Leu Gly Leu Val Leu Ser Glu Gln His Arg Lys Arg 485 490 495 Lys Pro Leu Arg Lys Thr Thr Lys Pro Ser Thr Glu Glu Leu Glu Ile 500 505 510 Thr Asn Ser Glu Pro Pro Ala Lys Lys Ile Lys Glu Thr Tyr Lys Arg 515 520 525 Cys Ala Phe Cys Pro Cys Asn Lys Asp Arg Lys Ser Arg Phe Ile Cys 530 535 540 Gln Lys Cys Glu Lys Ser Leu Cys Val Glu His Gln Tyr Val Ile Cys 545 550 555 560 Gln Asn Cys Leu <210> 179 <211> 628 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 179 Met Asp Leu Arg Lys Gln Asp Glu Lys Ile Arg Gln Trp Leu Glu Gln 1 5 10 15 Asp Ile Glu Glu Asp Ser Lys Gly Glu Ser Asp Asn Ser Ser Ser Glu 20 25 30 Thr Glu Asp Ile Val Glu Met Glu Val His Lys Asn Thr Ser Ser Glu 35 40 45 Ser Glu Val Ser Ser Glu Ser Asp Tyr Glu Pro Val Cys Pro Ser Lys 50 55 60 Arg Gln Arg Thr Gln Ile Ile Glu Ser Glu Glu Ser Asp Asn Ser Glu 65 70 75 80 Ser Ile Arg Pro Ser Arg Arg Gln Thr Ser Arg Val Ile Asp Ser Asp 85 90 95 Glu Thr Asp Glu Asp Val Met Ser Ser Thr Pro Gln Asn Ile Pro Arg 100 105 110 Asn Pro Asn Val Ile Gln Pro Ser Ser Arg Phe Leu Tyr Gly Lys Asn 115 120 125 Lys His Lys Trp Ser Ser Ala Ala Lys Pro Ser Ser Val Arg Thr Ser 130 135 140 Arg Arg Asn Ile Ile His Phe Ile Pro Gly Pro Lys Glu Arg Ala Arg 145 150 155 160 Glu Val Ser Glu Pro Ile Asp Ile Phe Ser Leu Phe Ile Ser Glu Asp 165 170 175 Met Leu Gln Gln Val Val Thr Phe Thr Asn Ala Glu Met Leu Ile Arg 180 185 190 Lys Asn Lys Tyr Lys Thr Glu Thr Phe Thr Val Ser Pro Thr Asn Leu 195 200 205 Glu Glu Ile Arg Ala Leu Leu Gly Leu Leu Phe Asn Ala Ala Ala Met 210 215 220 Lys Ser Asn His Leu Pro Thr Arg Met Leu Phe Asn Thr His Arg Ser 225 230 235 240 Gly Thr Ile Phe Lys Ala Cys Met Ser Ala Glu Arg Leu Asn Phe Leu 245 250 255 Ile Lys Cys Leu Arg Phe Asp Asp Lys Leu Thr Arg Asn Val Arg Gln 260 265 270 Arg Asp Asp Arg Phe Ala Pro Ile Arg Asp Leu Trp Gln Ala Leu Ile 275 280 285 Ser Asn Phe Gln Lys Trp Tyr Thr Pro Gly Ser Tyr Ile Thr Val Asp 290 295 300 Glu Gln Leu Val Gly Phe Arg Gly Arg Cys Ser Phe Arg Met Tyr Ile 305 310 315 320 Pro Asn Lys Pro Asn Lys Tyr Gly Ile Lys Leu Val Met Ala Ala Asp 325 330 335 Val Asn Ser Lys Tyr Ile Val Asn Ala Ile Pro Tyr Leu Gly Lys Gly 340 345 350 Thr Asp Pro Gln Asn Gln Pro Leu Ala Thr Phe Phe Ile Lys Glu Ile 355 360 365 Thr Ser Thr Leu His Gly Thr Asn Arg Asn Ile Thr Met Asp Asn Trp 370 375 380 Phe Thr Ser Val Pro Leu Ala Asn Glu Leu Leu Met Ala Pro Tyr Asn 385 390 395 400 Leu Thr Leu Val Gly Thr Leu Arg Ser Asn Lys Arg Glu Ile Pro Glu 405 410 415 Lys Leu Lys Asn Ser Lys Ser Arg Ala Ile Gly Thr Ser Met Phe Cys 420 425 430 Tyr Asp Gly Asp Lys Thr Leu Val Ser Tyr Lys Ala Lys Ser Asn Lys 435 440 445 Val Val Phe Ile Leu Ser Thr Ile His Asp Gln Pro Asp Ile Asn Gln 450 455 460 Glu Thr Gly Lys Pro Glu Met Ile His Phe Tyr Asn Ser Thr Lys Gly 465 470 475 480 Ala Val Asp Thr Val Asp Gln Met Cys Ser Ser Ile Ser Thr Asn Arg 485 490 495 Lys Thr Gln Arg Trp Pro Leu Cys Val Phe Tyr Asn Met Leu Asn Leu 500 505 510 Ser Ile Ile Asn Ala Tyr Val Val Tyr Val Tyr Asn Asn Val Arg Asn 515 520 525 Asn Lys Lys Pro Met Ser Arg Arg Asp Phe Val Ile Lys Leu Gly Asp 530 535 540 Gln Leu Met Glu Pro Trp Leu Arg Gln Arg Leu Gln Thr Val Thr Leu 545 550 555 560 Arg Arg Asp Ile Lys Val Met Ile Gln Asp Ile Leu Gly Glu Ser Ser 565 570 575 Asp Leu Glu Ala Pro Val Pro Ser Val Ser Asn Val Arg Lys Ile Tyr 580 585 590 Tyr Leu Cys Pro Ser Lys Ala Arg Arg Met Thr Lys His Arg Cys Ile 595 600 605 Lys Cys Lys Gln Ala Ile Cys Gly Pro His Asn Ile Asp Ile Cys Ser 610 615 620 Arg Cys Ile Glu 625 <210> 180 <211> 599 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 180 Met Ala Ser Arg Gln His Leu Tyr Gln Asp Glu Ile Ala Ala Ile Leu 1 5 10 15 Glu Asn Glu Asp Asp Tyr Ser Pro His Asp Thr Asp Ser Glu Met Glu 20 25 30 Asp Cys Val Thr Gln Asp Asp Val Arg Ser Asp Val Glu Asp Glu Met 35 40 45 Val Asp Asn Ile Gly Asn Gly Thr Ser Pro Ala Ser Arg His Glu Asp 50 55 60 Pro Glu Thr Pro Asp Pro Ser Ser Glu Ala Ser Asn Leu Glu Val Thr 65 70 75 80 Leu Ser Ser His Arg Ile Ile Ile Leu Pro Gln Arg Ser Ile Arg Glu 85 90 95 Lys Asn Asn His Ile Trp Ser Thr Thr Lys Gly Gln Ser Ser Gly Arg 100 105 110 Thr Ala Ala Ile Asn Ile Val Arg Thr Asn Arg Gly Pro Thr Arg Met 115 120 125 Cys Arg Asn Ile Val Asp Pro Leu Leu Cys Phe Gln Leu Phe Ile Lys 130 135 140 Glu Glu Ile Val Glu Glu Ile Val Lys Trp Thr Asn Val Glu Met Val 145 150 155 160 Gln Lys Arg Val Asn Leu Lys Asp Ile Ser Ala Ser Tyr Arg Asp Thr 165 170 175 Asn Glu Met Glu Ile Trp Ala Ile Ile Ser Met Leu Thr Leu Ser Ala 180 185 190 Val Met Lys Asp Asn His Leu Ser Thr Asp Glu Leu Phe Asn Val Ser 195 200 205 Tyr Gly Thr Arg Tyr Val Ser Val Met Ser Arg Glu Arg Phe Glu Phe 210 215 220 Leu Leu Arg Leu Leu Arg Met Gly Asp Lys Leu Leu Arg Pro Asn Leu 225 230 235 240 Arg Gln Glu Asp Ala Phe Thr Pro Val Arg Lys Ile Trp Glu Ile Phe 245 250 255 Ile Asn Gln Cys Arg Leu Asn Tyr Val Pro Gly Thr Asn Leu Thr Val 260 265 270 Asp Glu Gln Leu Leu Gly Phe Arg Gly Arg Cys Pro Phe Arg Met Tyr 275 280 285 Ile Pro Asn Lys Pro Asp Lys Tyr Gly Ile Lys Phe Pro Met Val Cys 290 295 300 Asp Ala Ala Thr Lys Tyr Met Val Asp Ala Ile Pro Tyr Leu Gly Lys 305 310 315 320 Ser Thr Lys Thr Gln Gly Leu Pro Leu Gly Glu Phe Tyr Val Lys Glu 325 330 335 Leu Thr Gln Thr Val His Gly Thr Asn Arg Asn Val Thr Cys Asp Asn 340 345 350 Trp Phe Thr Ser Val Pro Leu Ala Lys Ser Leu Leu Asn Ser Pro Tyr 355 360 365 Asn Leu Thr Leu Val Gly Thr Ile Arg Ser Asn Lys Arg Glu Ile Pro 370 375 380 Glu Glu Val Lys Asn Ser Arg Ser Arg Gln Val Gly Ser Ser Met Phe 385 390 395 400 Cys Phe Asp Gly Pro Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ser 405 410 415 Lys Met Val Phe Leu Leu Ser Ser Cys Asn Glu Asp Ala Val Val Asn 420 425 430 Gln Ser Asn Gly Lys Pro Asp Met Ile Leu Phe Tyr Asn Gln Thr Lys 435 440 445 Gly Gly Val Asp Ser Phe Asp Gln Met Cys Ser Ser Met Ser Thr Asn 450 455 460 Arg Lys Thr Asn Arg Trp Pro Met Ala Val Phe Tyr Gly Met Leu Asn 465 470 475 480 Met Ala Phe Val Asn Ser Tyr Ile Ile Tyr Cys His Asn Met Leu Ala 485 490 495 Lys Lys Glu Lys Pro Leu Ser Arg Lys Asp Phe Met Lys Lys Leu Ser 500 505 510 Thr Asp Leu Thr Thr Pro Ser Met Gln Lys Arg Leu Glu Ala Pro Thr 515 520 525 Leu Lys Arg Ser Leu Arg Asp Asn Ile Thr Asn Val Leu Lys Ile Val 530 535 540 Pro Gln Ala Ala Ile Asp Thr Ser Phe Asp Glu Pro Glu Pro Lys Lys 545 550 555 560 Arg Arg Tyr Cys Gly Phe Cys Ser Tyr Lys Lys Lys Arg Met Thr Lys 565 570 575 Thr Gln Cys Phe Lys Cys Lys Lys Pro Val Cys Gly Glu His Asn Ile 580 585 590 Asp Val Cys Gln Asp Cys Ile 595 <210> 181 <211> 567 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 181 Met Ala Arg Ser Thr Arg Glu Ala Lys Ser Cys Ala Leu Glu Arg Ile 1 5 10 15 Leu Gly Arg Glu Met Asn Met Pro Asp Ala Gln Ile Asp Leu Glu Glu 20 25 30 Ser Asp Lys Glu Glu His Leu Ser Asp Ile Glu Glu Ala Glu Leu Glu 35 40 45 Val Ala Leu Ser Asp Ala Ser Asp Gly Ser Ser Ser Ser Cys Ser Arg 50 55 60 Pro Glu Ser Pro Glu Pro Ala Ala Gln Ala Glu Ala Val Gly His Arg 65 70 75 80 Tyr Val Ser Pro Ser Gly Gln Ala Trp Ser Thr Asn Pro Pro Ala Arg 85 90 95 Cys Gly Gln Arg Pro Ala Gly Asn Ile Leu Arg Leu Arg Pro Gly Ile 100 105 110 Thr Gln Phe Ala Thr Ala Arg Leu His Asp Glu Glu Ser Ala Phe Lys 115 120 125 Leu Leu Phe Asp Ala Asp Met Val Asp Thr Ile Val Val Glu Thr Asn 130 135 140 Arg Glu Ala Thr Arg Val Leu Gly Gln Ala Trp Leu Pro Thr Thr Arg 145 150 155 160 Val Glu Met Tyr Gly Tyr Ile Gly Leu Cys Phe Leu Arg Gly Val Phe 165 170 175 Lys Gly Asn Met Glu Ser Ile Glu Glu Leu Trp Ser Ala Asp Cys Gly 180 185 190 Arg Lys Ile Phe Ala Glu Thr Met Ser Leu Ser Arg Phe Lys Ser Leu 195 200 205 Leu Arg Phe Leu Arg Phe Asp Asn Arg Glu Thr Arg Ala Ala Arg Leu 210 215 220 Gln Arg Asp Lys Leu Ala Ala Val Arg Leu Leu Leu Asp Gly Leu Val 225 230 235 240 Ser Asn Ser Gln Arg Ser Tyr Val Pro Ser Gly Ala Val Thr Val Asp 245 250 255 Glu Gln Leu Phe Pro Tyr Arg Gly Arg Cys Arg Tyr Ile Gln Tyr Met 260 265 270 Pro Met Lys Pro Ala Lys Tyr Gly Leu Lys Phe Trp Cys Leu Asn Asp 275 280 285 Ala Ala Asn Ala Tyr Cys Trp Asn Leu Gln Met Tyr Val Gly Arg Glu 290 295 300 Glu Asp Arg Glu Val Ser Leu Gly Glu His Val Val Leu Arg Leu Ala 305 310 315 320 Glu Gly Leu Arg Gly Ser Gly Met Gly Ile Thr Val Asp Asn Phe Phe 325 330 335 Cys Ser Leu Ser Leu Ala Arg Arg Leu Gln Arg Trp Asn Leu Thr Leu 340 345 350 Leu Gly Ser Met Arg Ser His Arg Arg Glu Val Pro Leu Gln Met Arg 355 360 365 Ser Cys Arg Asn Arg Gln Leu His Ser Thr Glu Phe Val Tyr Thr Glu 370 375 380 Glu Asp Lys Ile Gln Leu Ala Ala Tyr Lys Ala Lys Pro Asn Lys Leu 385 390 395 400 Val Leu Ile Leu Ser Ser Gln His Ser Ser Pro Ala Val Ser Ala His 405 410 415 Pro Ala Gln Lys Pro Gln Val Ile Leu Asp Tyr Asn Ala Thr Lys Gly 420 425 430 Gly Thr Asp Leu Met Asp Gln Met Thr Ser Cys Tyr Ser Thr Lys Tyr 435 440 445 Lys Ser Arg Arg Trp His Val Pro Val Phe Cys Asn Leu Leu Asn Ile 450 455 460 Ala Gly Leu Asn Ser Phe Leu Leu His Gln Thr Val Phe Pro Asn Arg 465 470 475 480 Phe Ala Asn Ala Pro His Arg Arg Arg Leu Tyr Leu Val Ala Leu Gly 485 490 495 Arg Ala Leu Thr Gln Pro Leu Arg Tyr Gln Val Glu Ala Gly Arg Asn 500 505 510 Pro Pro Ala Thr Val Pro Val His Gly Val Gln Arg Gly Arg Cys His 515 520 525 Met Cys Gly Arg Ser Lys Asp Arg Lys Thr Arg Thr Arg Cys Thr His 530 535 540 Cys Asp Arg Phe Cys Cys Ala Glu His Leu Gln Glu Ile Cys Leu Ala 545 550 555 560 Cys Thr Gly Asp Met Pro Glu 565 <210> 182 <211> 564 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 182 Met Ser Asp Ser Ser Asp Asp Asp Ile Val Ser Pro Gly Met Lys Arg 1 5 10 15 Lys Arg Val Asn Ile Phe Pro Ser Ser Ser Glu Glu Asn Asp Glu Ser 20 25 30 Ile Glu Ser Asp Ser Glu Thr Asp Gln Tyr Asp Ser Asp Asp Ile Tyr 35 40 45 Ser Glu Asp Asn Lys Asn Asn Lys Glu Asn Gln Tyr Thr Asn Val Lys 50 55 60 Trp Lys Ser Thr Ser Gly Asn Arg Lys Pro Phe Asp Phe Ile Ala Asn 65 70 75 80 Asn Gly Gln Gln Glu Ile Val Pro Gly Arg Phe Arg Ser Lys Cys Ser 85 90 95 Ser Tyr Val Glu Lys Tyr Leu Asp Asp His Leu Ile Ser Ile Ile Val 100 105 110 Lys Glu Thr Asn Leu Tyr Ala Asp Gln Phe Leu Gln Ser His Pro Asn 115 120 125 Leu Lys Pro Arg Ser Arg Met Arg Lys Trp Tyr Ser Thr Thr Asn Asn 130 135 140 Glu Val Arg Cys Phe Ile Ala Ile Leu Ile Leu Gln Gly Ile Val Lys 145 150 155 160 Lys Pro Ala Leu Asp Met Tyr Phe Leu Lys Arg Glu Ile Ile Cys Ser 165 170 175 Pro Phe Phe Gly Lys Ile Phe Ser Ala Asp Arg Phe Leu Leu Leu Cys 180 185 190 Lys Phe Leu Tyr Phe Glu Asn Asn Ala Pro His Asn Asp Met Pro Ser 195 200 205 Lys Lys Leu Cys Lys Ile Lys Thr Val Leu Glu Tyr Val Ile Asn Lys 210 215 220 Cys Lys Ser Leu Tyr Thr Pro Lys Met Asp Ile Cys Ile Asp Glu Ser 225 230 235 240 Leu Leu Met Trp Lys Gly Arg Leu Ser Trp Arg Gln Tyr Ile Pro Ser 245 250 255 Lys Arg Ser Arg Phe Gly Ile Gln Phe Phe Val Leu Cys Glu Ser Glu 260 265 270 Ser Gly Tyr Ile Trp Asn Phe Phe Ile Tyr Thr Gly Lys Glu Thr Tyr 275 280 285 Cys Asp Ser Gln Tyr Ser Glu Phe Asn Ile Ser Ala Arg Ile Val Leu 290 295 300 Gln Leu Cys Asp Glu Leu Phe Glu Arg Gly Tyr Arg Leu Tyr Leu Asp 305 310 315 320 Asn Trp Tyr Thr Gly Val Pro Phe Ile Glu Lys Leu Cys Ala His Lys 325 330 335 Thr Asp Val Val Gly Thr Ile Arg Lys Asn Arg Ile Gly Ile Cys Glu 340 345 350 Glu Val Arg Glu Thr Arg Ile Lys Lys Gly Glu Tyr Ile Ala Arg Phe 355 360 365 Lys Asn Lys Ile Met Leu Leu Lys Trp Arg Asp Lys Arg Glu Val Tyr 370 375 380 Leu Val Ser Thr Val His Asn Asp Asn Ile Val Glu Met Gln Lys Arg 385 390 395 400 Asn Val Ile Lys Lys Val Pro Glu Val Val Phe Asp Tyr Asn Asn Lys 405 410 415 Met Gly Gly Val Asp Met Ser Asp Ser Ile Ile Ile Ala Tyr Ser Thr 420 425 430 Ala Arg Lys Arg Leu Lys Lys Tyr Tyr Lys Lys Ile Phe Leu His Leu 435 440 445 Leu Asp Val Ile Cys Leu Asn Ser Tyr Leu Ile Tyr Lys Met Asn Gly 450 455 460 Gly Lys Leu Ser Arg Ile His Phe Leu Leu Glu Tyr Ile Glu Asp Thr 465 470 475 480 Ile Ala Ser Tyr Pro Ile Glu Ser Arg Asn Leu Pro Lys Ser Arg Ser 485 490 495 Thr Ala Pro Asn Val Ser Arg Leu Ile Glu Lys His Phe Pro Asp Tyr 500 505 510 Ile Pro Gly Ser Ser Arg Thr Thr Asn Pro Ser Arg Arg Cys Ala Val 515 520 525 Cys Tyr Lys Lys Lys Ile Arg Lys Glu Ser Arg Tyr Trp Cys Pro Thr 530 535 540 Cys Gln Val Pro Leu Cys Val Val Pro Cys Phe Arg Glu Tyr His Thr 545 550 555 560 Thr Glu Thr Ile <210> 183 <211> 553 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 183 Met Phe Ser Arg Lys Arg Phe Cys Asp Glu Asp Ser Glu Asn Cys Ala 1 5 10 15 Ile Asn Phe Ala Asn Glu Ser Asp Ser Ser Asp Glu Ile Cys Lys Phe 20 25 30 Arg Arg Lys Tyr Arg Arg Ile Ile Val Asp Asp Thr Ser Asp Asp Asp 35 40 45 Gln Leu Pro Glu Ser Trp Val Trp Asn Glu Arg Arg Asn Ser Pro Lys 50 55 60 Ile Trp Asp Tyr Thr Met Thr Pro Gly Ile Ser Glu Ala Ala Leu Cys 65 70 75 80 Gln Leu Gly Gly Ser Arg Gly Glu Phe Asp Thr Phe Asn Leu Thr Phe 85 90 95 Asp Asp Ile Phe Trp Asn Asn Ile Val Thr Glu Thr Asn Gln Tyr Ala 100 105 110 Asn Gln Leu Arg Glu Asn Pro His Thr Arg Arg Lys Ile Asp Glu Thr 115 120 125 Trp Phe Pro Val Asp Ser Thr Glu Ile Lys Arg Tyr Phe Ala Leu Thr 130 135 140 Ile Ile Met Ala Gln Ile Lys Lys Pro Arg Ile Gln Met Asn Trp Ser 145 150 155 160 Lys Arg Ala Val Ile Glu Thr Pro Ile Phe Arg Lys Ser Met Pro Leu 165 170 175 Lys Arg Tyr Leu Gln Ile Thr Arg Phe Leu His Phe Ser Asn Asn Asn 180 185 190 Leu Val Ala Asn Thr Asp Lys Leu Lys Lys Val Arg Pro Val Ile Asn 195 200 205 Phe Leu Asn Gln Lys Phe Lys Glu Leu Tyr Ile Met Arg Lys Asp Ile 210 215 220 Ser Ile Asp Glu Ser Leu Met Lys Phe Arg Gly Arg Leu Ser Tyr Lys 225 230 235 240 Gln Phe Asn Pro Ser Lys Arg Ala Arg Phe Gly Val Lys Phe Tyr Lys 245 250 255 Leu Cys Glu Ser Asp Ser Gly Tyr Cys Tyr Glu Phe Lys Ile Tyr Thr 260 265 270 Gly Asn Asp Lys Ile Asn Cys Lys Asp Ser Ala Ser Glu Ser Val Val 275 280 285 Lys Glu Leu Ser Glu Ser Val Leu His Arg Gly His Thr Leu Tyr Ile 290 295 300 Asp Ser Trp Tyr Ser Ser Pro Lys Leu Phe Met Ile Leu Ser His Lys 305 310 315 320 Tyr Lys Thr Asn Val Ile Gly Thr Val Arg Ser Asn Arg Lys Asn Met 325 330 335 Pro Lys Asp Leu Cys Ser Val Lys Leu Lys Arg Gly Glu Tyr Val Ile 340 345 350 Arg Ser Cys Asn Arg Val Leu Ala Leu Lys Trp Arg Asp Lys Arg Asp 355 360 365 Val Tyr Met Met Ser Thr Lys His Glu Thr Ala Glu Met Thr Ser Gln 370 375 380 Gly Ser Lys Arg Thr Leu Lys Pro Asn Cys Ile Thr Glu Tyr Asn Lys 385 390 395 400 Gly Met Asn Gly Ile Asp Leu Gln Asp Gln Ile Leu Ala Cys Phe Pro 405 410 415 Ile Met Arg Lys Tyr Met Lys Gly Tyr Lys Lys Ile Phe Phe Tyr Leu 420 425 430 Phe Asp Ile Gly Leu Phe Asn Ser Tyr Ile Leu Trp Lys Lys Leu Asn 435 440 445 Asp Gly Lys Lys Gln Cys Tyr Val Asp Tyr Lys Ile Asn Ile Ala Glu 450 455 460 Ser Leu Leu Lys Lys Met Pro Lys Pro Ile Tyr Lys Glu Arg Gly Val 465 470 475 480 Leu Ser Ser Gly Asp Ala Pro Asp Arg Leu Cys Ala Lys Glu Trp Ala 485 490 495 His Phe Pro Lys His Ile Asp Pro Thr Pro Ser Lys Leu Arg Pro Ser 500 505 510 Lys Arg Cys Thr Val Cys His Lys Asn Lys Lys Arg Lys Glu Thr Thr 515 520 525 Trp Glu Cys Lys Lys Cys Lys Val Pro Leu His Val Pro Glu Cys Phe 530 535 540 Glu Arg Tyr His Thr Val Thr Asp Tyr 545 550 <210> 184 <211> 616 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 184 Met Ser Glu Ile Asn Asn Ala Gly Asn Ser Lys Ser Lys Arg Pro Ser 1 5 10 15 Thr Gly Ser Val Gln Gly Pro Ala Arg Lys Asn Phe Arg Val Ala Asp 20 25 30 Pro Thr Phe Glu Gln Glu Val Ser Glu Leu Leu Ala Ser Asp Gln Ser 35 40 45 Asp Asn Glu Glu Asn Ile Glu Gly Leu Phe Ile Leu Glu Asn Glu Leu 50 55 60 Ile Gln Asn His Glu Ser Asp Asn Asp Glu Asp Gln Asp Gln Glu Ser 65 70 75 80 Asp Gln Val Leu Gly Glu Glu Thr Asp Ser Asp Ser Ser Asp Asn Ile 85 90 95 Pro Leu Ala Gln Phe Val Ala Ser Asn Tyr Tyr Tyr Gly Lys Asn Arg 100 105 110 Tyr Lys Trp Ser Lys Thr Pro Pro Leu Ala Arg Val Arg Thr Pro Gln 115 120 125 His Asn Ile Ile Thr Ser Arg Ala Gly Ser Ser Lys Leu Thr Ser Glu 130 135 140 Asp Gly Lys Asp His Tyr Ser Ile Trp Asn Lys Leu Phe Asp Glu Glu 145 150 155 160 Met Leu Gln Cys Ile Leu Thr Trp Thr Asn His Arg Ile Ser Ser Tyr 165 170 175 Arg Thr Lys Tyr Val Arg Tyr Asn Arg Pro Glu Leu Asn Asp Leu Asp 180 185 190 Met Val Glu Leu Lys Ala Phe Ile Gly Leu Leu Phe Tyr Ser Ala Val 195 200 205 Leu Lys Ser Asn Asp Glu Asn Thr Ser Tyr Leu Phe Ala Ser Asp Gly 210 215 220 Thr Gly Cys Glu Ile Phe Arg Cys Gly Met Ser Glu Thr Arg Phe Leu 225 230 235 240 Val Leu Leu Leu Cys Leu Arg Phe Asp Asn Pro Asp Asp Arg Glu Glu 245 250 255 Arg Met Lys Ala Asp Lys Leu Ala Ala Ile Ser His Ile Phe Asn Lys 260 265 270 Phe Val Ser Asn Ser Gln Gln Leu Tyr Glu Leu Ser Glu Cys Val Thr 275 280 285 Val Asp Glu Met Leu Val Lys Phe Arg Gly Arg Ser Tyr Met Ile Ser 290 295 300 Tyr Met Pro Lys Lys Pro Gly Lys Tyr Gly Leu Ile Ile Arg Ala Leu 305 310 315 320 Cys Asp Ala Asn Asn Phe Tyr Phe Tyr Asn Gly Tyr Ile Tyr Ser Gly 325 330 335 Lys Gly Ser Asp Gly Ile Gly Leu Thr Ala Gln Glu Lys Lys Phe Leu 340 345 350 Val Pro Thr Gln Cys Val Leu Arg Leu Thr Lys Pro Ile His Gly Thr 355 360 365 Asn Arg Asn Val Thr Ala Asp Asn Trp Phe Ser Ser Ile Glu Leu Val 370 375 380 Asp Gln Leu Ser Ser Arg Lys Leu Thr Tyr Val Gly Thr Leu Lys Lys 385 390 395 400 Asn Lys Arg Glu Ile Pro Lys Glu Phe Gln Pro Lys Lys Gln Arg Glu 405 410 415 Val Asn Ser Thr Leu Phe Gly Phe Thr Ser Thr Lys Thr Leu Cys Ser 420 425 430 Tyr Val Pro Lys Lys Asn Arg Ala Val Ile Leu Val Ser Ser Met His 435 440 445 His Ser Asn Gln Val Asp Glu Asn Thr Lys Lys Pro Glu Ile Ile Met 450 455 460 Tyr Tyr Asn Ser Thr Lys Gly Gly Val Asp Glu Ala Asp Lys Lys Cys 465 470 475 480 Ser Ile Tyr Ser Ser Ser Arg Arg Thr Arg Arg Trp Pro Met Val Leu 485 490 495 Leu Tyr Arg Val Leu Asp Leu Thr Ala Met Asn Ala Tyr Ile Leu Tyr 500 505 510 Asn Met His Gln Pro Lys Ala Val Glu Arg Gly Asp Phe Leu Lys Lys 515 520 525 Leu Ala Arg Val Leu Val Val Pro His Val Gln Arg Arg Val Ile Asn 530 535 540 Ala Arg Leu Pro Arg Glu Leu Arg Leu Thr Met Asn Arg Val Leu Gly 545 550 555 560 Asp Asp Met Val Thr Glu Gly Val Gln Asp Gln Glu Thr Ile Gln Gly 565 570 575 Ser Arg Arg Ala Cys Arg Ile Cys Pro Ala Lys Lys His Arg Met Thr 580 585 590 Thr Tyr Val Cys Val Gly Cys Lys Lys Pro Val Cys Leu Gln Cys Ser 595 600 605 Arg Pro Leu Cys Thr Asp Cys Gln 610 615 <210> 185 <211> 609 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 185 Met Phe Tyr Ser Met Ser Val Val Asn Leu Leu Ile Phe Tyr Ser Ile 1 5 10 15 Leu Pro Thr Met Ser Leu Ser Asn His Pro Asp Arg Ile Leu Thr Leu 20 25 30 Leu Glu Glu Ser Asp Ser Glu Asp Glu Asn Asn Asp Thr Ala Ser Asp 35 40 45 Val Asp Asn Glu Asp His Leu Ser Glu Arg Ser Asn Asn Ser Asp Ser 50 55 60 Glu Glu Asp Ala Ser Ser Ile Asp Ser Asp Ser Ser Glu Asn Leu Asp 65 70 75 80 Leu Leu Ser Leu Gln Asn Arg Leu Arg Gln Gln Val Phe Arg Gly Lys 85 90 95 Asp Gly Thr Leu Trp Gln Lys Glu Pro Gly Arg Ser Asn Val Arg Thr 100 105 110 Arg Ser Glu Asn Ile Ile Thr Glu Leu Pro Gly Val Lys Leu Ile Ala 115 120 125 Arg Asp Ala Lys Thr Val Phe Glu Cys Trp Asn Leu Phe Ile Thr Gln 130 135 140 Asp Met Leu Tyr Thr Ile Lys Thr Cys Thr Asn Ser His Ile Gln Glu 145 150 155 160 Arg Arg Ala Leu Cys Ala Asp Val Ser Lys Gln Arg Phe Met Ser Glu 165 170 175 Val Glu Ile Ser Glu Leu Lys Ala Phe Ile Gly Leu Leu Tyr Leu Ala 180 185 190 Gly Phe Tyr Arg Ser Asn Arg Gln Asn Leu Lys Asp Leu Trp Gln Lys 195 200 205 Asp Gly Thr Gly Ile Glu Ile Phe Arg Leu Thr Met Ser Ile Gln Arg 210 215 220 Phe Tyr Phe Ile Gln Ser Cys Leu Arg Phe Asp Asp Lys Asn Thr Arg 225 230 235 240 Ala Glu Arg Gln Asn Leu Asp Asn Leu Ala Pro Ile Arg Glu Leu Phe 245 250 255 Lys Glu Phe Thr Glu Gln Cys Leu Ser Met Tyr Ser Pro Gly Glu Asn 260 265 270 Cys Thr Ile Asp Glu Met Leu Val Ala Phe Arg Gly Arg Cys Lys Phe 275 280 285 Arg Gln Tyr Ile Pro Ser Lys Pro Ala Lys Tyr Gly Ile Lys Ile Phe 290 295 300 Ala Leu Val Asp Ser Lys Thr Phe Tyr Val Lys Asn Leu Glu Ile Tyr 305 310 315 320 Ala Gly Lys Gln Pro Ser Gly Pro Tyr Ser Val Ser Asn Lys Pro Phe 325 330 335 Asp Val Val Asn Arg Leu Val Leu Pro Ile Ser Lys Thr His Arg Asn 340 345 350 Val Thr Phe Asp Asn Trp Phe Thr Ser Tyr Glu Val Val Ser His Leu 355 360 365 Leu Asn Glu His Arg Leu Thr Thr Val Gly Thr Val Arg Lys Asn Lys 370 375 380 Lys Gln Ile Pro Pro Gln Phe Leu Asn Ile Arg Gly Lys Glu Leu Asn 385 390 395 400 Ser Ser Thr Phe Gly Phe Gln Lys Asp Ile Ser Leu Val Ser Tyr Ile 405 410 415 Pro Lys Lys Asn Lys Ile Val Leu Leu Met Ser Ser Leu His His Asp 420 425 430 Ala Asn Ile Asp Gln Ser Thr Gly Asp Gln Arg Lys Pro Glu Ile Ile 435 440 445 Thr Tyr Tyr Asn Ala Thr Lys Ser Gly Val Asp Val Ala Asp Glu Leu 450 455 460 Ser Ala Thr Tyr Asp Val Ser Arg Asn Ser Lys Arg Trp Pro Met Thr 465 470 475 480 Ser Phe Tyr Ala Met Leu Asn Ile Ser Gly Ile Asn Ala Asn Ile Ile 485 490 495 Tyr Arg Ala Asn Asn Thr Asp Thr Arg Met Thr Arg Arg His Phe Leu 500 505 510 Lys Lys Leu Gly Leu Asp Leu Ile His Asp His Leu Glu Val Arg Lys 515 520 525 Thr Gln Met Asn Leu Pro Arg Leu Leu Arg Lys Arg Ile Leu Asp Phe 530 535 540 Val Gly Gly Pro Ala Glu Glu Pro Pro Arg Lys Ile Thr Gly Thr Arg 545 550 555 560 Lys Arg Cys Gln Ile Cys Pro Ala Lys Lys Asp Lys Lys Thr Asn His 565 570 575 Thr Cys His Val Cys His Ile Tyr Ile Cys Pro Asp His Ile Ile Pro 580 585 590 Tyr Cys Asn Asn Cys Ser Thr Ser Met Ala Ile Ser Asp Asp Val Glu 595 600 605 Asp <210> 186 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 186 Met Thr Arg Glu Ser Ile Ser Ser Asp Glu Ile Ile Arg Ile Leu Met 1 5 10 15 Asn Glu Asp Glu Ala Asn Gly Asp Asp Ile Phe Glu Glu Glu Cys Ser 20 25 30 Asp Asp Asp Phe Val Glu Glu Asp Asp Ala Ala Asn Asp Glu Val Asp 35 40 45 Val Glu Ser Val Val Asp Ser Glu Asn Glu Ser Glu Ile Ile Val Thr 50 55 60 Glu Ser Lys Thr Ser Gly Lys Arg Lys Arg Val Gly Cys Asn Gly Asn 65 70 75 80 Ala Gln Ala Leu Lys Lys Gly Lys Lys Ser Asp Asn Cys Trp Phe Thr 85 90 95 Gln Glu Gly Thr Ile Val Thr Pro Lys Lys Arg Ile Leu Ile Gly Lys 100 105 110 Asn Gly His Thr Trp His Ser Glu Pro Pro Pro Leu Gly Lys Thr Pro 115 120 125 Glu Arg Asn Ile Val Met Arg Met Pro Gly Pro Lys Arg Ala Ala Lys 130 135 140 Glu Ala Ile Ser Glu Arg Gln Cys Trp Asn Leu Phe Leu Asn Ser Asp 145 150 155 160 Met Met Thr Ile Val Val Lys Asn Thr Asn Glu Glu Ile Ala Arg Gln 165 170 175 Arg Gln Asn Tyr Ser Ser Ala Gln Ser Phe Thr Gly Asp Thr Cys Thr 180 185 190 Glu Glu Met His Ala Tyr Phe Gly Ile Leu Ile Thr Ser Ala Ala Leu 195 200 205 Lys Asp Asn His Leu Ser Val Glu Asp Met Trp Asn Asn Phe Tyr Gly 210 215 220 Lys Pro Leu Tyr Arg Ala Ala Met Ser Lys Glu Arg Phe Arg Phe Leu 225 230 235 240 Thr Asn Cys Met Arg Phe Asp Asp Lys Asn Thr Arg Asp Ala Arg Lys 245 250 255 Ala Ser Asp Pro Phe Ala Ala Ile Arg Asp Ile Thr Asp Met Phe Ala 260 265 270 Ser Asn Cys Gln Glu Met Tyr Thr Pro Ser Thr Cys Cys Thr Ile Asp 275 280 285 Glu Gln Leu Leu Ala Phe Arg Gly Arg Cys Pro Phe Arg Ile Tyr Ile 290 295 300 Pro Asn Lys Pro Ala Lys Tyr Gly Ile Lys Leu Val Met Leu Cys Asp 305 310 315 320 Ser Lys Thr Phe Tyr Ala Val Asn Ile Ile Pro Tyr Val Gly Lys Ala 325 330 335 Thr His Asn Gly Asp Ile Pro Leu Ala Asp Tyr Phe Val Lys Glu Leu 340 345 350 Ser Lys Pro Ile His Gly Thr Asn Arg Asn Ile Thr Thr Asp Asn Trp 355 360 365 Phe Thr Ser Val Ser Leu Gly Ser Ser Leu Leu Glu Asp Tyr Lys Leu 370 375 380 Thr Thr Val Gly Thr Leu Arg Lys Asn Lys Lys Glu Ile Pro Pro Glu 385 390 395 400 Met Thr Met Val Ser Gly Arg Lys Leu Glu Thr Ser Leu Phe Ile Phe 405 410 415 Asp Asp Lys Lys Thr Met Thr Ser Phe Tyr Pro Lys Lys Asn Lys Met 420 425 430 Val Leu Leu Leu Ser Thr Met His Gln Gly Lys Tyr Val Ile Pro Glu 435 440 445 Thr Lys Lys Pro Glu Ile Ile Glu Phe Tyr Asn Lys Thr Lys Gly Gly 450 455 460 Val Asp Thr Met Asp Gln Leu Cys Asn Thr Tyr Ser Cys Ser Arg Lys 465 470 475 480 Thr Arg Arg Trp Pro Leu Cys Val Phe Tyr Gly Leu Met Asn Ile Ala 485 490 495 Gly Val Asn Ala Ala Val Ile Tyr Asn Thr Asn Met Ala Val Lys Gly 500 505 510 Arg Glu Ile Ile Pro Arg Lys Thr Phe Leu Leu Arg Leu Gly Arg Glu 515 520 525 Leu Val Ile Pro Trp Ile Glu Ala Arg Ser Val Lys Pro Thr Leu Gln 530 535 540 Ser Lys Val Arg Gln Val Ile Ser Glu Val Leu Gly Leu Glu Asn Thr 545 550 555 560 Gln Lys Asp Asn Ser Asn Val Asn Gln Gln Val Asn Ser Gly Lys Lys 565 570 575 Ala Gly Arg Cys Ser Val Cys Pro Arg Lys Asn Asp Arg Lys Thr Thr 580 585 590 Val Lys Cys Asp Lys Cys Lys Glu Phe Val Cys Asn Ala His Lys Ile 595 600 605 Ser Leu Cys Gln Lys Cys Lys 610 615 <210> 187 <211> 568 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 187 Met Gly Asp Tyr Glu Lys Glu Gln Gln Arg Leu Leu Ala Leu Trp Glu 1 5 10 15 Asp Met Glu Ser Asp Asp Glu Val Ile Asn Asn Asp Asp Ser Glu Glu 20 25 30 Glu Asp Ile Asp Asn Ile Ser Val Cys Ser Asp Tyr Pro Asp Met Glu 35 40 45 Gln Asp Ala Glu Asp Glu Leu Glu Pro Ala Glu Glu Gln Thr Gln Ala 50 55 60 Lys Tyr Phe Phe Gly Lys Asp Gly Thr Lys Trp Ser Lys Gln His Pro 65 70 75 80 Asn Lys Lys Val Arg Thr Arg Ala Glu Asn Ile Ile Ile His Leu Pro 85 90 95 Gly Val Lys Lys Pro Ala Lys Met Ala Lys Thr Pro Leu Glu Cys Phe 100 105 110 Ser Leu Phe Ile Asp Glu Gln Met Ile Ala Asp Ile Val Glu Arg Thr 115 120 125 Asn Glu Arg Ile Thr Glu Lys Cys Ala Gln Trp Lys Asp Ser Pro His 130 135 140 Tyr Gly Gln Thr Ser Ala Val Glu Ile Lys Ala Ile Phe Gly Leu Leu 145 150 155 160 Tyr Leu Ser Gly Val Phe Arg Asn Asn His Arg His Leu Tyr Glu Leu 165 170 175 Trp Asn Thr Asp Gly Thr Gly Met Asp Ile Phe Pro Ala Thr Met Ser 180 185 190 Gln Arg Arg Cys Glu Phe Leu Ile Ser Cys Leu Arg Phe Asp Asn Lys 195 200 205 Ser Asn Arg Ala Glu Arg Val Asn Val Asp Lys Leu Ala His Ile Arg 210 215 220 Ala Ile Phe Asp Arg Phe Val Gln Asn Cys Gln Ser Ala Tyr Ser Pro 225 230 235 240 Ser Glu Tyr Leu Thr Ile Asp Glu Lys Leu Glu Ser Phe Arg Gly Lys 245 250 255 Cys Ser Phe Arg Gln Phe Ile Pro Asn Lys Pro Ala Arg Tyr Gly Ile 260 265 270 Lys Val His Ala Leu Val Asp Ala Arg Thr Tyr Tyr Val Leu Asn Met 275 280 285 Glu Val Tyr Val Gly Gln Gln Pro Gln Gly Pro Phe Arg Val Ser Asn 290 295 300 Lys Pro Lys Asp Ile Ile Asp Arg Leu Val Ala Pro Val Ser Lys Thr 305 310 315 320 Asn Arg Asn Ile Thr Phe Asp Asn Trp Tyr Thr Ser Leu Glu Leu Leu 325 330 335 Gln Ser Leu Arg Gln Lys His Gln Leu Thr Ala Val Gly Thr Ile Arg 340 345 350 Lys Asn Lys Pro Tyr Leu Pro Pro Ala Phe Leu Asn Val Lys Asn Arg 355 360 365 Asp Ile Cys Ser Thr Leu Phe Gly Phe His Glu Gly Asn Thr Leu Val 370 375 380 Ser Tyr Cys Pro Lys Lys Gly Lys Val Val Leu Leu Leu Ser Ser Leu 385 390 395 400 His His Asp Asp Ala Val Asp Gln Thr Asp Lys Lys Leu Pro Glu Val 405 410 415 Ile Ser Phe Tyr Asn Phe Thr Lys Cys Gly Val Asp Val Val Asp Glu 420 425 430 Met Ser Ala Ser Tyr Asn Val Ser Arg Asn Ser Arg Arg Trp Pro Leu 435 440 445 Thr Leu Phe Tyr Ser Leu Leu Asn Thr Thr Gly Ile Asn Ser Gln Ile 450 455 460 Ile Tyr Arg Glu Asn Asn Asn Gly Ile Lys Met Ala Arg Arg His Phe 465 470 475 480 Leu Lys Lys Leu Gly Ile Gln Leu Val Glu Ala His Gln Arg Ser Arg 485 490 495 Met Ser Asn Pro Arg Leu Thr Arg Glu Leu Arg Gly Asn Ile Arg Lys 500 505 510 Leu Leu Lys Glu Leu Leu Pro Ser Glu Val Phe Glu Tyr Ser Glu Pro 515 520 525 Leu Ser Lys Lys Arg Asn Phe Gln Gln Gly Arg Cys Ser Glu Cys Pro 530 535 540 Arg Ala Lys Asp Arg Lys Thr Arg Tyr Val Cys Glu Ala Cys Asp Lys 545 550 555 560 Phe Ile Cys Leu Ile Leu Tyr Ala 565 <210> 188 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 188 Met Glu Pro Asp Glu Cys Arg Arg Ile Gln Asp Leu Leu Gln Glu Val 1 5 10 15 Glu Glu Glu Glu Leu Val Ser Ser Glu Asp Glu Asp Ser Glu Val Asp 20 25 30 Glu Val Gln Phe Ser Asp His Asn Ser Glu Ser Glu Leu Ser Glu Glu 35 40 45 Glu Met Pro Val Val Glu Leu His Asp Gly Pro Thr Tyr Lys Gly Arg 50 55 60 Asp Asn Val Thr Thr Trp Arg Lys His Gln Leu Pro Arg Asn Val Arg 65 70 75 80 Thr Arg Gln Gln Asn Ile Val Ile His Leu Pro Gly Val Arg Pro Ile 85 90 95 Gly Gln Asn Ser Asn Thr Pro Lys Glu Cys Phe Ser Leu Ile Phe Asp 100 105 110 Asp Thr Met Ile Glu Thr Ile Val Ala Ser Thr Asn Ile Lys Ile Ala 115 120 125 Lys His Ser Glu Lys Asn Lys Asn Asp Arg Ser Thr Tyr Leu Thr Ser 130 135 140 Ile Thr Glu Met Asn Ala Leu Phe Gly Leu Leu Ile Leu Ser Gly Leu 145 150 155 160 Val Lys Ser Gly His Gln Asn Leu Glu Asp Leu Trp Asn Val His Gln 165 170 175 Leu Gly Ile Asp Ile Phe Gln Thr Thr Met Ser Leu Lys Arg Phe Lys 180 185 190 Phe Leu Ile Arg Tyr Met Arg Phe Asp Asp Ile Asn Thr Arg His Ala 195 200 205 Arg Arg Gln Glu Asp Lys Leu Ala Pro Ile Arg Glu Ile Phe Glu Arg 210 215 220 Phe Asn His Asn Cys Lys Gln Val Tyr Thr Val Ser Glu Tyr Cys Thr 225 230 235 240 Leu Asp Glu Gln Leu Val Pro Phe Arg Gly Arg Cys Ser Phe Arg Met 245 250 255 Tyr Ile Pro Ser Lys Pro Ala Lys Tyr Gly Leu Lys Ile Phe Thr Leu 260 265 270 Val Asp Ala Arg Thr Trp Tyr Ile Leu Lys Ser Glu Val Tyr Val Gly 275 280 285 Lys Gln Asn Asp Gly Ser Phe Lys Val Ser Asn Thr Thr Val Asp Val 290 295 300 Thr Met Arg Leu Thr Glu Pro Ile His Arg Ser Gly Arg Asn Leu Thr 305 310 315 320 Ile Asp Asn Trp Phe Thr Ser Phe Pro Leu Ala Glu Leu Leu Leu Gln 325 330 335 Gln Asn Val Thr Met Val Gly Thr Met Lys Lys Asn Lys Lys Glu Leu 340 345 350 Pro Pro Glu Leu Leu Ala Lys Gly Arg Pro Glu Lys Ser Ser Val Phe 355 360 365 Ala Tyr Gln Asn Asn Lys Thr Val Val Ser Tyr Val Pro Lys Lys Asn 370 375 380 Lys Asn Val Val Leu Leu Ser Thr Met His Leu Glu Asp Gly Thr Ile 385 390 395 400 Asp Glu Thr Thr Gly Glu Asp Ser Lys Pro Glu Ile Ile Thr Phe Tyr 405 410 415 Asn Met Thr Lys Gly Gly Val Asp Val Val Asp Lys Leu Cys Ser Thr 420 425 430 Tyr Ser Thr Ala Arg Lys Thr Asn Arg Trp Pro Leu Val Leu Leu Phe 435 440 445 Arg Ile Leu Asp Leu Ala Ser Val Asn Ser Tyr Val Val Phe Gln Gly 450 455 460 Asn Asn Pro Gln Ser Lys Met Asn Arg Lys Ser Phe Leu Gln Glu Leu 465 470 475 480 Gly Phe Thr Leu Val Ala Gln Gln Val Gln Thr Arg Ala Thr Gln Met 485 490 495 Arg Leu Pro Lys Glu Ile Arg Gln Arg Ala Ala Lys Arg Ala Lys Met 500 505 510 Asp Asn Ala Ile Ala Pro Ala Val Pro Pro Asn Pro Gly Gln Arg Ser 515 520 525 Arg Cys Thr Val Cys Pro Arg Lys Asn Asp Met Lys Val Lys Thr Thr 530 535 540 Cys Phe Lys Cys Asn Lys Tyr Met Cys Asn Lys His Met Lys Thr Val 545 550 555 560 Cys Glu Pro Cys Leu Ala Pro Ala Glu Asn Thr Ser Ser Asp Ser Asp 565 570 575 Tyr <210> 189 <211> 589 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 189 Met Arg Arg Leu Val Phe Arg Met Cys Ser Asn Lys Asp Asp Glu Val 1 5 10 15 Gln Leu Glu Thr Phe Leu Asn Ser Phe Thr Leu Asp Asp Ala Ala Ile 20 25 30 Asp Pro Gln Tyr Glu Asp Asp Glu Asp Asp Asp Glu Ala Asp His Leu 35 40 45 Glu Glu Arg Thr Glu Cys Thr Asp Thr Glu Glu Glu Ile Ser Asp Thr 50 55 60 Glu Glu Asp Phe Gly Thr Ser Pro Thr Ser Asp Ala Phe Tyr Val Cys 65 70 75 80 Lys Asp Gly Val Thr Lys Trp Asn Lys Lys Leu Ala Pro Lys His Glu 85 90 95 Arg Val Pro Glu Asn Leu Leu Lys His Leu Pro Ser Pro Arg Thr Ala 100 105 110 Thr Lys Asn Leu Ile Ser Glu Ile Asp Ile Trp Ser Tyr Phe Phe Asn 115 120 125 Glu Gly Met Leu Lys Val Ile Val Asp Cys Thr Asn Gln His Ile Ser 130 135 140 Gly Thr Lys Ser His Phe Ser Arg Glu Arg Asp Ala Glu Asp Thr Asn 145 150 155 160 Ile His Glu Ile Lys Ala Leu Leu Gly Leu Ile Tyr Met Ala Gly Val 165 170 175 Leu Lys Ala Asn Arg Leu Asn Ala Arg Glu Leu Phe Ser Thr Gln Gly 180 185 190 Cys Gly Ile Glu Ile Phe Arg Leu Thr Met Ser Ile Asn Arg Phe Leu 195 200 205 Phe Leu Met Arg Asn Val Arg Phe Asp Asn Lys Glu Thr Arg Glu Gln 210 215 220 Arg Lys Glu Ile Asp Lys Leu Ala Pro Ile Arg Gln Ile Phe Asp Asn 225 230 235 240 Phe Val Val Asn Cys Gln Ser Ala Tyr Ser Pro Phe His Cys Val Thr 245 250 255 Ile Asp Glu Lys Leu Glu Gly Phe Arg Gly Arg Cys Ser Phe Lys Gln 260 265 270 Tyr Ile Pro Ser Lys Pro Asn Lys Tyr Gly Ile Lys Ile Phe Ala Leu 275 280 285 Val Asp Ala Lys Cys Tyr Phe Thr Thr Asn Leu Glu Val Tyr Val Gly 290 295 300 Lys Gln Pro Asp Gly Pro Tyr Ala Val Asp Asn Ser Ala Ser Ala Val 305 310 315 320 Val Gln Arg Leu Cys Glu Pro Ile Asn Glu Ser Gly Arg Asn Val Thr 325 330 335 Thr Asp Asn Trp Phe Thr Ser Ile Gln Leu Leu Glu Ala Leu Lys Glu 340 345 350 Lys Lys Leu Thr Leu Leu Gly Thr Ile Arg Lys Asn Arg Lys Gly Leu 355 360 365 Pro Lys Glu Phe Thr Gln Pro Pro Lys Ser Arg Ala Val Met Ser Thr 370 375 380 Leu Phe Gly Phe Arg Asp Asn Ala Thr Leu Val Ser Tyr Lys Pro Lys 385 390 395 400 Lys Asn Lys Asn Val Leu Leu Ile Ser Ser Gly His His Asp Asp Gly 405 410 415 Ile Asp Glu Asn Thr Gln Lys Pro Asn Met Ile Leu Asp Tyr Asn Asn 420 425 430 Thr Lys Gly Gly Val Asp Thr Val Asp Lys Leu Cys Ala Ser Tyr Asn 435 440 445 Cys Ala Arg Ile Thr Arg Arg Trp Pro Met Val Val Phe Tyr Ala Leu 450 455 460 Leu Asn Ile Ala Gly Ile Asn Ser Ile Val Ile His Lys Phe Asn Asn 465 470 475 480 Pro Thr Val Thr Gln Pro Arg Arg Thr Phe Leu Arg Asn Leu Ser Met 485 490 495 Ala Leu Ile Asp Gly His Leu Arg Gln Arg Ala Gln Leu His Cys Leu 500 505 510 Pro Arg Gln Met Ser Ser Arg Ile Arg Glu Ile Thr Gly Tyr Glu Glu 515 520 525 Pro Leu Gln Gly Ala Ala Ala Thr Pro Ser Asp Glu Asn Ile Pro Lys 530 535 540 Arg Gly Arg Cys Ala Tyr Cys Asp Arg Arg Lys Asn Arg Pro Thr Lys 545 550 555 560 Tyr Ser Cys Thr Thr Cys Gln Lys Phe Met Cys Leu Glu His Cys Thr 565 570 575 Ile Val Cys Glu Glu Cys Phe Asn Lys Asp Glu Ile Phe 580 585 <210> 190 <211> 567 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 190 Met Phe Ser Gly Lys Arg Phe Arg Asp Glu Ser Ser Val Asn Cys Ala 1 5 10 15 Asn Asn Phe Ala Asn Glu Ser Asp Ser Ser Asp Asp Ile Cys Cys Val 20 25 30 Arg Arg Lys Cys Arg Arg Leu Val Ile Asp Asp Thr Ser Asp Asp Gln 35 40 45 Leu Pro Glu Ser Trp Leu Trp Thr Lys Ile Arg Asn Ser Gln Lys Ile 50 55 60 Trp Glu Tyr Thr Met Ser Pro Gly Ile Lys Glu Ala Ala Leu Cys Gln 65 70 75 80 Leu Gly Gly Gly Arg Arg Glu Phe Asp Ile Phe Asn Leu Ile Phe Asp 85 90 95 Asp Ile Phe Trp Asn Asn Ile Val Thr Glu Thr Ser Gln Tyr Ala Asp 100 105 110 Gln Ile Arg Ala Asn Pro His Ser Ser Arg Glu Ile Asp Glu Thr Trp 115 120 125 Phe Pro Val Asp Ser Ser Glu Ile Lys Arg Tyr Leu Val Leu Thr Ile 130 135 140 Ile Met Ala Gln Val Lys Lys Pro Arg Ile Gln Met Asn Trp Ser Lys 145 150 155 160 Arg Ala Val Ile Glu Thr Leu Ile Phe Arg Lys Ser Met Pro Leu Lys 165 170 175 Arg Tyr Leu Gln Ile Thr Arg Cys Leu His Phe Ser Asn Asn Asn Leu 180 185 190 Val Ala Asn Thr Asp Lys Leu Ser Lys Ile Lys Ser Val Ile Asn Phe 195 200 205 Leu Asn Gln Lys Phe Lys Glu Val Tyr Ile Met Lys Glu Asp Ile Ala 210 215 220 Ile Asp Glu Ser Leu Met Lys Phe Lys Gly Arg Leu Ser Tyr Lys Gln 225 230 235 240 Phe Asn Pro Ser Lys Arg Thr Arg Phe Gly Val Lys Phe Tyr Lys Leu 245 250 255 Cys Glu Ser Asp Ser Gly Tyr Cys Tyr Glu Phe Lys Ile Tyr Thr Gly 260 265 270 His Asp Lys Thr Asn Tyr Asp Asp Ser Ala Ser Glu Ser Val Val Lys 275 280 285 Glu Leu Ser Glu Ser Val Leu His Arg Gly His Thr Leu Tyr Ile Asp 290 295 300 Asn Trp Tyr Ser Ser Pro Arg Leu Phe Met Thr Leu Ser His Lys Tyr 305 310 315 320 Lys Thr Asn Val Ile Gly Thr Val Arg Gly Asn Arg Lys His Met Pro 325 330 335 Lys Asp Leu Cys Asn Val Lys Leu Lys Arg Gly Glu Tyr Thr Ile Arg 340 345 350 Ser Cys Asn Arg Ile Leu Ala Ile Lys Trp Lys Asp Lys Arg Asp Val 355 360 365 Tyr Ile Met Ser Thr Lys His Glu Thr Val Glu Met Thr Ala Gln Arg 370 375 380 Tyr Tyr Arg Thr Pro Lys Pro Asn Cys Ile Leu Glu Tyr Asn Lys Gly 385 390 395 400 Met Ile Arg Ile Asp Leu Gln Asp Gln Ile Leu Ala Cys Phe Pro Val 405 410 415 Met Arg Lys Tyr Met Lys Gly Tyr Lys Lys Ile Phe Phe Tyr Leu Phe 420 425 430 Gly Ile Asp Leu Phe Asn Ser Tyr Ile Leu Trp Lys Lys Ile Asn Lys 435 440 445 Glu Lys Lys Gln Cys Tyr Ile Asp Tyr Arg Ile Asn Ile Ala Glu Ser 450 455 460 Leu Leu Lys Asn Met Pro Lys Pro Asn Tyr Arg Glu Arg Gly Gly Leu 465 470 475 480 Ser Phe Gly Asp Ala Pro Glu Arg Leu His Ala Lys His Trp Ala His 485 490 495 Phe Pro Lys His Ile Asp Pro Thr Ala Ser Lys Leu Arg Pro Ser Lys 500 505 510 Pro Cys Arg Val Cys Gln Lys Asn Lys Lys Arg Ser Glu Thr Thr Trp 515 520 525 Gly Cys Lys Lys Cys Lys Val Pro Leu His Leu Pro Ile Phe Thr Ser 530 535 540 Thr Arg Met Leu Arg Ile Ile Ser His His Cys Arg Leu Leu Ile Leu 545 550 555 560 Tyr Tyr Cys Phe Leu Tyr Lys 565 <210> 191 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 191 Met Ser Leu Ala Arg Phe Leu Ala Glu Glu Ala Leu Ser Gln Leu Met 1 5 10 15 Asn Trp Asp Ser Asp Val Glu Glu Asp Ile Ser Glu Thr Glu Asp Ala 20 25 30 Ser Glu Pro Glu Asp Tyr Val Ile Asp Asp Pro Gly Cys Gln Phe Ser 35 40 45 Leu Asp Asp Glu Asp Ser Glu Asp Gly Ser Ala Gly Val Pro Ser Ser 50 55 60 Asn Glu Asn Gln Glu Met Gln Lys Pro Pro Ser Thr Glu Gly Thr Leu 65 70 75 80 Thr Ser Lys Asp Gly Gln Ile Lys Trp Ser Thr Ser Pro His Gln Thr 85 90 95 Gln Ala Arg Leu Ser Ser Ser Asn Ala Ile Lys Met Thr Pro Gly Pro 100 105 110 Thr Arg Phe Ala Leu Thr Arg Val Asp Gly Ile Glu Ser Ala Phe Gln 115 120 125 Leu Phe Ile Ser Pro Pro Ile Glu Lys Ile Ile Leu Asp Met Thr Asn 130 135 140 Leu Glu Gly Arg Arg Val Phe Gln Glu Lys Trp Lys Pro Leu Asp Pro 145 150 155 160 Ser Asp Leu His Ala Tyr Ile Gly Ile Leu Val Leu Ala Gly Val Tyr 165 170 175 Arg Ser Lys Gly Glu Ala Thr Ala Ser Leu Trp Ser Glu Glu Tyr Gly 180 185 190 Arg Pro Ile Phe Arg Ala Thr Met Ser Leu Glu Thr Phe His Met Ile 195 200 205 Ser Arg Val Ile Arg Phe Asp Asn Arg Ala Thr Arg Ala Gly Arg Arg 210 215 220 Glu Lys Asp Lys Leu Ala Ala Ile Arg Asp Val Trp Asp Lys Trp Val 225 230 235 240 Lys Ile Leu Pro Leu Leu Tyr Asn Pro Gly Pro His Val Thr Val Gly 245 250 255 Glu Arg Leu Ile Pro Phe Arg Gly Arg Cys Pro Phe Arg Gln Tyr Val 260 265 270 Pro Lys Lys Pro Ala Lys Tyr Gly Ile Lys Ile Trp Ala Ala Cys Asp 275 280 285 Ala Lys Ser Ser Tyr Ala Trp Asn Met Gln Val Tyr Thr Gly Lys Pro 290 295 300 Leu Gly Gly Pro Pro Glu Lys Asn Gln Gly Met Arg Val Val Leu Glu 305 310 315 320 Met Thr Glu Gly Leu Gln Gly His Asn Ile Thr Cys Asp Asn Phe Phe 325 330 335 Thr Ser Tyr Arg Leu Gly Val Glu Leu Gln Lys Arg Lys Leu Thr Met 340 345 350 Leu Gly Thr Val Arg Lys Asn Lys Pro Glu Leu Pro Cys Glu Ile Leu 355 360 365 Lys Met Gln Gly Arg Pro Leu His Ser Ser Lys Phe Thr Phe Thr Glu 370 375 380 Asn Thr Thr Leu Val Ser Tyr Cys Pro Lys Arg Asn Lys Asn Val Leu 385 390 395 400 Val Met Ser Thr Met His Lys Asp Ala Ser Leu Ser Thr Arg Glu Asp 405 410 415 Met Lys Pro Gln Met Ile Leu Asp Tyr Asn Ser Thr Lys Glu Gly Val 420 425 430 Asp Asn Leu Asp Lys Val Thr Ala Thr Tyr Ser Cys Gln Arg Lys Ser 435 440 445 Thr Arg Trp Pro Leu Val Val Phe Tyr Asn Ile Val Asp Val Ser Ala 450 455 460 Tyr Asn Ala Tyr Val Leu Trp Thr Glu Ile Asn Gln His Trp Asn Ala 465 470 475 480 Ser Lys Leu Tyr Arg Arg Arg Met Phe Leu Glu Glu Leu Gly Lys Ala 485 490 495 Leu Val Thr Pro Lys Ile Gln Asn Arg Ala Arg Pro Ala Arg Ser Pro 500 505 510 Ala Ala Ala Ala Val Ile Ala Asn Val Gln Val Arg Ala Ser Asp Gln 515 520 525 Pro Thr Met Asp Pro Leu Asp Lys Cys Ala Lys Lys Arg Lys Arg Cys 530 535 540 Gln Val Cys Pro Ser Arg Asp Asp Ser Lys Thr Ser Thr Ser Cys Val 545 550 555 560 Arg Cys Lys Lys Cys Ile Cys Arg Lys His Thr Val Thr Phe Cys Pro 565 570 575 Ser Cys Gly Glu Asn 580 <210> 192 <211> 3037 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 192 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacccttggc atgcctggta gggtttatta gacccaccac 420 tttgaaaaac ctatgatatt tttttaaatt gaaggctatt gttgacgtgt gttatagtag 480 cttcgcgcaa taaaccggcg gccattttga cgagcgaact tcagtctcac gtgagcgtgc 540 gtgcgagtag cacgtgtgta aagtgcgcgc gggcccgtgg gaccctacca ggcatacaac 600 gtaacattct gtcggtaaga atattttctt tattttttgg catttctttg tttaatgtgt 660 taaattataa tacgaaaaaa atattgttgc agtagaagtt tagcttgcct cgtccccgcc 720 gggtcacccg gccagcgaca tggaggccca gaataccctc cttgacagtc ttgacgtgcg 780 cagctcaggg gcatgatgtg actgtcgccc gtacatttag cccatacatc cccatgtata 840 atcatttgca tccatacatt ttgatggccg cacggcgcga agcaaaaatt acggctcctc 900 gctgcagacc agcgagcagg gaaacgctcc cctcacagac gcgttgaatt gtccccacgc 960 cgcgcccctg tagagaaata taaaaggtta ggatttgcca ctgaggttct tctttcatat 1020 acttcctttt aaaatcttgc taggatacag ttctcacatc acatccgaac ataaacaaca 1080 atgtctgtta ttaatttcac aggtagttct ggtccattgg tgaaagtttg cggcttgcag 1140 agcacagagg ccgcagaatg tgctctagat tccgatgctg acttgctggg tattatatgt 1200 gtgcccaata gaaagagaac aattgacccg gttattgcaa ggaaaatttc aagtcttgta 1260 aaagcatata aaaatagttc aggcactccg aaatacttgg ttggcgtgtt tcgtaatcaa 1320 cctaaggagg atgttttggc tctggtcaat gattacggca ttgatatcgt ccaactgcat 1380 ggagatgagt cgtggcaaga ataccaagag ttcctcggtt tgccagttat taaaagactc 1440 gtatttccaa aagactgcaa catactactc agtgcagctt cacagaaacc tcattcgttt 1500 attcccttgt ttgattcaga agccggtggg acaggtgaac ttttggattg gaactcgatt 1560 tctgactggg ttggaaggca agagagcccc gaaagcttac attttatgtt agctggtgga 1620 ctgacgccag aaaatgttgg tgatgcgctt agattaaatg gcgttattgg tgttgatgta 1680 agcggaggtg tggagacaaa tggtgtaaaa gactctaaca aaatagcaaa tttcgtcaaa 1740 aatgctaaga aatagtcagt actgacaata aaaagattct tgttttcaag aacttgtcat 1800 ttgtatagtt tttttatatt gtagttgttc tattttaatc aaatgttagc gtgatttata 1860 ttttttttcg cctcgacatc atctgcccag atgcgaagtt aagtgcgcag aaagtaatat 1920 catgcgtcaa tcgtatgtga atgctggtcg ctatactgct gtcgattcga tactaacgcc 1980 gccatccagt gtcgaaacgc tatgatccaa tatcaaagga atcttttcga ttatccaaag 2040 ataatagtat tttagttgat ttattagtgc cttaaattaa tgaaagtctg acttcgatct 2100 ctgcattata tgtaagattg ttaattatag aactaagagt ttaatttctg ttaattaaaa 2160 ttaagcgatt ttgaataatt gttaaataaa gatattttca catacattta catattttat 2220 ttattatctg taataataat acattctaaa agacataaat ataaaacaaa attttcctag 2280 cttgttcatt tgtgtaaaac atgtattttc aatatcgggt ttgacagacc caccaggcat 2340 gccgtgtgat ttttatgtac caggcatgtc aagggttaag ccgctaaagg cattatccgc 2400 caagtacaat tttttactct tcgaagatag aaaatttgct gacattggta atacagtcaa 2460 attgcagtac tctgcgggtg tatacagaat agcagaatgg gcagacatta cgaatgcaca 2520 cggtgtggtg ggcccaggta ttgttagcgg tttgaagcag gcggcagaag aagtaacaaa 2580 ggaacctaga ggccttttga tgttagcaga attgtcatgc aagggctccc tatctactgg 2640 agaatatact aagggtactg ttgacattgc gaaaagcgac aaagattttg ttatcggctt 2700 tattgctcaa agagacatgg gtggaagaga tgaaggttac gattggttga ttatgacacc 2760 cggtgtgggt ttagatgaca agggagatgc attgggtcaa cagtatagaa ccgtggatga 2820 tgttgtctct acaggatctg acattattat tgttggaaga ggactatttg caaagggaag 2880 ggatgctaag gtagagggtg aacgttacag aaaagcaggc tgggaagcat atttgagaag 2940 atgcggccag caaaactaaa aaactgtatt ataagtaaat gcatgtatac taaactcaca 3000 aattagagct tcaatttaat tatatcagtt attaccc 3037 <210> 193 <211> 2333 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 193 ttaacccttg gcatgcctgg tagggtttat tagacccacc actttgaaaa acctatgata 60 tttttttaaa ttgaaggcta ttgttgacgt gtgttatagt agcttcgcgc aataaaccgg 120 cggccatttt gacgagcgaa cttcagtctc acgtgagcgt gcgtgcgagt agcacgtgtg 180 taaagtgcgc gcgggcccgt gggaccctac caggcataca acgtaacatt ctgtcggtaa 240 gaatattttc tttatttttt ggcatttctt tgtttaatgt gttaaattat aatacgaaaa 300 aaatattgtt gcagtagaaa gagtagtctt ccagctgctt catccccgtg gcccgttgct 360 cgcgtttgct ggcggtgtcc ccggaagaaa tatatttgca tgtctttagt tctatgatga 420 cacaaacccc gcccagcgtc ttgtcattgg cgaaaacacg cagatgcagt cggggcggcg 480 cggtcccagg tccacttcgc atattaaggt gacgcgtgtg gcctcgaaca cagagcgact 540 ctgcagggtg gcatggccac ctcagcaagt tcccacttga acaaaaacat caagcaaatg 600 tacctgtgcc tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtact 660 ggagaaggac tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag 720 ttacctgagt ggaattttga tggctctagt acctttcagt ctgagggctc caacagtgac 780 atgtatctca gccctgttgc catgtttcgg gaccccttcc gccgggagcc caacaagctg 840 gtgttctgtg aagttttcaa gtacaaccgg aagcctgcag agacaaattt aaggcactcc 900 tgtaaacgga taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag 960 tatactctga tgggaacaga tgggcaccct tttggttggc cttccaatgg ctttcctggg 1020 ccccaaggtc cgtattactg tggtgtgggc gcagacaaag cctatggcag ggatatcgtg 1080 gaggctcact accgcgcctg cttgtatgct ggggtcaaga ttacaggaac aaatgctgag 1140 gtcatgcctg cccagtggga gttccaaata ggaccctgtg aaggaatcca catgggagat 1200 catctctggg tggcccgttt catcttgcat cgagtatgtg aggactttgg ggtaatagca 1260 acctttgacc ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt 1320 agcaccaagg ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc catcgagaaa 1380 ctaagcaagc ggcaccagta ccacattcga gcctacgatc ccaagggggg cctggacaat 1440 gcccgtcgtc tgactgggtt ccacgaaacg tccaacatca acgacttttc tgctggtgtc 1500 gccaatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac 1560 tttgaagatc gccgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc 1620 cgcacatgcc ttctcaatga gactggcgac gagcccttcc aatacaaaaa ctggatccgc 1680 tcagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgataa 1740 ttagactttg agtgatcttg agccctcgct ttcttgctgt ccaatttcta ttaaaggttc 1800 ctttgttccc taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg 1860 gattctgcct aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga 1920 atattttact aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaaatcttt 1980 tcgattatcc aaagataata gtattttagt tgatttatta gtgccttaaa ttaatgaaag 2040 tctgacttcg atctctgcat tatatgtaag attgttaatt atagaactaa gagtttaatt 2100 tctgttaatt aaaattaagc gattttgaat aattgttaaa taaagatatt ttcacataca 2160 tttacatatt ttatttatta tctgtaataa taatacattc taaaagacat aaatataaaa 2220 caaaattttc ctagcttgtt catttgtgta aaacatgtat tttcaatatc gggtttgaca 2280 gacccaccag gcatgccgtg tgatttttat gtaccaggca tgtcaagggt taa 2333 <210> 194 <211> 2231 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 194 ttaacccttg gcatgcctgg tagggtttat tagacccacc actttgaaaa acctatgata 60 tttttttaaa ttgaaggcta ttgttgacgt gtgttatagt agcttcgcgc aataaaccgg 120 cggccatttt gacgagcgaa cttcagtctc acgtgagcgt gcgtgcgagt agcacgtgtg 180 taaagtgcgc gcgggcccgt gggaccctac caggcataga gtagtcttcc agctgcttca 240 tccccgtggc ccgttgctcg cgtttgctgg cggtgtcccc ggaagaaata tatttgcatg 300 tctttagttc tatgatgaca caaaccccgc ccagcgtctt gtcattggcg aaaacacgca 360 gatgcagtcg gggcggcgcg gtcccaggtc cacttcgcat attaaggtga cgcgtgtggc 420 ctcgaacaca gagcgactct gcagggtggc atggccacct cagcaagttc ccacttgaac 480 aaaaacatca agcaaatgta cctgtgcctg ccccagggtg agaaagtcca agccatgtat 540 atctgggttg atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag 600 cccaagtgtg tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct 660 gagggctcca acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc 720 cgggagccca acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag 780 acaaatttaa ggcactcctg taaacggata atggacatgg tgagcaacca gcacccctgg 840 tttggaatgg aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct 900 tccaatggct ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc 960 tatggcaggg atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt 1020 acaggaacaa atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa 1080 ggaatccaca tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgag 1140 gactttgggg taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca 1200 ggctgccata ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc 1260 gaggaggcca tcgagaaact aagcaagcgg caccagtacc acattcgagc ctacgatccc 1320 aaggggggcc tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac 1380 gacttttctg ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc 1440 caggagaaga aaggttactt tgaagatcgc cgcccctctg ccaattgtga cccctttgca 1500 gtgacagaag ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa 1560 tacaaaaact ggatccgctc agacatgata agatacattg atgagtttgg acaaaccaca 1620 actagaatgc agtgataatt agactttgag tgatcttgag ccctcgcttt cttgctgtcc 1680 aatttctatt aaaggttcct ttgttcccta agtccaacta ctaaactggg ggatattatg 1740 aagggccttg agcatctgga ttctgcctaa taaaaaacat ttattttcat tgcaatgatg 1800 tatttaaatt atttctgaat attttactaa aaagggaatg tgggaggtca gtgcatttaa 1860 aacataaaga aaatcttttc gattatccaa agataatagt attttagttg atttattagt 1920 gccttaaatt aatgaaagtc tgacttcgat ctctgcatta tatgtaagat tgttaattat 1980 agaactaaga gtttaatttc tgttaattaa aattaagcga ttttgaataa ttgttaaata 2040 aagatatttt cacatacatt tacatatttt atttattatc tgtaataata atacattcta 2100 aaagacataa atataaaaca aaattttcct agcttgttca tttgtgtaaa acatgtattt 2160 tcaatatcgg gtttgacaga cccaccaggc atgccgtgtg atttttatgt accaggcatg 2220 tcaagggtta a 2231 <210> 195 <211> 2078 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 195 ttaacccttg gcatgcctgg tagggtttat tagacccacc actttgaaaa acctatgata 60 tttttttaaa ttgaaggcta ttgttgacgt gtgttatagt agcttcgcgc aataaaccgg 120 cggccatttt gacgagcgaa cttcagtctc acgtgagcgt gcgtgcgagt agcacgtgtg 180 taaagtgcgc gcgggcccgt gggaccctac caggcataca acgtaacatt ctgtcggtaa 240 gaatattttc tttatttttt ggcatttctt tgtttaatgt gttaaattat aatacgaaaa 300 aaatattgtt gcagtagaaa gagtagtctt ccagctgctt catccccgtg gcccgttgct 360 cgcgtttgct ggcggtgtcc ccggaagaaa tatatttgca tgtctttagt tctatgatga 420 cacaaacccc gcccagcgtc ttgtcattgg cgaaaacacg cagatgcagt cggggcggcg 480 cggtcccagg tccacttcgc atattaaggt gacgcgtgtg gcctcgaaca cagagcgact 540 ctgcagggtg gcatggccac ctcagcaagt tcccacttga acaaaaacat caagcaaatg 600 tacctgtgcc tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtact 660 ggagaaggac tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag 720 ttacctgagt ggaattttga tggctctagt acctttcagt ctgagggctc caacagtgac 780 atgtatctca gccctgttgc catgtttcgg gaccccttcc gccgggagcc caacaagctg 840 gtgttctgtg aagttttcaa gtacaaccgg aagcctgcag agacaaattt aaggcactcc 900 tgtaaacgga taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag 960 tatactctga tgggaacaga tgggcaccct tttggttggc cttccaatgg ctttcctggg 1020 ccccaaggtc cgtattactg tggtgtgggc gcagacaaag cctatggcag ggatatcgtg 1080 gaggctcact accgcgcctg cttgtatgct ggggtcaaga ttacaggaac aaatgctgag 1140 gtcatgcctg cccagtggga gttccaaata ggaccctgtg aaggaatcca catgggagat 1200 catctctggg tggcccgttt catcttgcat cgagtatgtg aggactttgg ggtaatagca 1260 acctttgacc ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt 1320 agcaccaagg ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc catcgagaaa 1380 ctaagcaagc ggcaccagta ccacattcga gcctacgatc ccaagggggg cctggacaat 1440 gcccgtcgtc tgactgggtt ccacgaaacg tccaacatca acgacttttc tgctggtgtc 1500 gccaatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac 1560 tttgaagatc gccgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc 1620 cgcacatgcc ttctcaatga gactggcgac gagcccttcc aatacaaaaa ctggatccgc 1680 tcagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgataa 1740 ttagactttg agtgatcttg agccctcgct ttcttgctgt ccaatttcta ttaaaggttc 1800 ctttgttccc taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg 1860 gattctgcct aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga 1920 atattttact aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaacctagc 1980 ttgttcattt gtgtaaaaca tgtattttca atatcgggtt tgacagaccc accaggcatg 2040 ccgtgtgatt tttatgtacc aggcatgtca agggttaa 2078 <210> 196 <211> 3319 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 196 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccgtctgc agctgacgtg tagtcccaca gacaccgcga 420 aatacaaaat cacgtgttat accgtcattt ttcaaatatg agcgtcactg ctgcgagtac 480 cttactgtat agtgctcgcg cgtcggtcag tgtgcggcgg ggggtcgcag cgagcgcacg 540 tgtgcgtagc ggagggaagg tgtccacgag actaccacgt cagcgttaag gtaagtgtcc 600 acgagattac cacttcagtg aaatggttat atcttcatag tgtctcctaa acaaccacgt 660 cagtcattga gtttcaatga tttattattt tatgttattt tccaattttc ataaactatt 720 tatactacta ttttattact acttatacta cttacaatta ggacagattt ctacttttgt 780 ttgtaatcaa ttaacttgaa tacaaagccg tttatttaac atacaaacaa cataacaata 840 cataataatg ttatctctga gtaacacagg ttacaggaaa caatatctat acagcacccg 900 cgtgtgctta agtcgtgcta gaaaactaac agtatttaac ttgtttttag gtttagcttg 960 cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc ctccttgaca 1020 gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt tagcccatac 1080 atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg cgaagcaaaa 1140 attacggctc ctcgctgcag accagcgagc agggaaacgc tcccctcaca gacgcgttga 1200 attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg ccactgaggt 1260 tcttctttca tatacttcct tttaaaatct tgctaggata cagttctcac atcacatccg 1320 aacataaaca acaatgtctg ttattaattt cacaggtagt tctggtccat tggtgaaagt 1380 ttgcggcttg cagagcacag aggccgcaga atgtgctcta gattccgatg ctgacttgct 1440 gggtattata tgtgtgccca atagaaagag aacaattgac ccggttattg caaggaaaat 1500 ttcaagtctt gtaaaagcat ataaaaatag ttcaggcact ccgaaatact tggttggcgt 1560 gtttcgtaat caacctaagg aggatgtttt ggctctggtc aatgattacg gcattgatat 1620 cgtccaactg catggagatg agtcgtggca agaataccaa gagttcctcg gtttgccagt 1680 tattaaaaga ctcgtatttc caaaagactg caacatacta ctcagtgcag cttcacagaa 1740 acctcattcg tttattccct tgtttgattc agaagccggt gggacaggtg aacttttgga 1800 ttggaactcg atttctgact gggttggaag gcaagagagc cccgaaagct tacattttat 1860 gttagctggt ggactgacgc cagaaaatgt tggtgatgcg cttagattaa atggcgttat 1920 tggtgttgat gtaagcggag gtgtggagac aaatggtgta aaagactcta acaaaatagc 1980 aaatttcgtc aaaaatgcta agaaatagtc agtactgaca ataaaaagat tcttgttttc 2040 aagaacttgt catttgtata gtttttttat attgtagttg ttctatttta atcaaatgtt 2100 agcgtgattt atattttttt tcgcctcgac atcatctgcc cagatgcgaa gttaagtgcg 2160 cagaaagtaa tatcatgcgt caatcgtatg tgaatgctgg tcgctatact gctgtcgatt 2220 cgatactaac gccgccatcc agtgtcgaaa cgctatgatc caatatcaaa ggattttgaa 2280 actctctagt ttttaagttg accaacgaat gtatctcaat tttcctagac tgattaatgt 2340 tattgtgaac ttttaaaatg tataatgtga aatttgaaaa atttgatttt gttatttttt 2400 tatgtcataa atgtttaaga agaaatttat agactgattt gtgttaagta aataaacctt 2460 gtttaatttt gaaaatagat attgtttttt tttttatttc aattaaatat aaaatataaa 2520 aaggcaagaa atctaacaaa catgaataaa ttagctgcat attttaattc taaaaaaata 2580 tttgctgttg aaatggtgtc tggtatacta ccacctcagt tgaattgtaa caatttaacc 2640 acgtcagttg cagagggtta agccgctaaa ggcattatcc gccaagtaca attttttact 2700 cttcgaagat agaaaatttg ctgacattgg taatacagtc aaattgcagt actctgcggg 2760 tgtatacaga atagcagaat gggcagacat tacgaatgca cacggtgtgg tgggcccagg 2820 tattgttagc ggtttgaagc aggcggcaga agaagtaaca aaggaaccta gaggcctttt 2880 gatgttagca gaattgtcat gcaagggctc cctatctact ggagaatata ctaagggtac 2940 tgttgacatt gcgaaaagcg acaaagattt tgttatcggc tttattgctc aaagagacat 3000 gggtggaaga gatgaaggtt acgattggtt gattatgaca cccggtgtgg gtttagatga 3060 caagggagat gcattgggtc aacagtatag aaccgtggat gatgttgtct ctacaggatc 3120 tgacattatt attgttggaa gaggactatt tgcaaaggga agggatgcta aggtagaggg 3180 tgaacgttac agaaaagcag gctgggaagc atatttgaga agatgcggcc agcaaaacta 3240 aaaaactgta ttataagtaa atgcatgtat actaaactca caaattagag cttcaattta 3300 attatatcag ttattaccc 3319 <210> 197 <211> 2957 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 197 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacccttaat tggtcgcgtg gggtgtcata caccccagag 420 cgggttccca ggcgcacaac tttttaaaat ttgaatttag cgcgctgctc ttctaggtag 480 cttcgtaaac acgtaaaacg tacatgattc agttgcgagc ggcgctcggt tgtggacggt 540 tgagctcaga gagtgtgttt ggggtgcacg acaccccagg tgactgtttg tgtggtctaa 600 attccgagta agtaaatagt tgttaatttt attatttccg ttttaaaaca ttgtattttg 660 caagtgatga atgttaaaag tgttcaatta taataatttg acatttttga ggttatgttg 720 tgatattttt gtttttggtt ttcagtaaaa tcaaaagttt agcttgcctc gtccccgccg 780 ggtcacccgg ccagcgacat ggaggcccag aataccctcc ttgacagtct tgacgtgcgc 840 agctcagggg catgatgtga ctgtcgcccg tacatttagc ccatacatcc ccatgtataa 900 tcatttgcat ccatacattt tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg 960 ctgcagacca gcgagcaggg aaacgctccc ctcacagacg cgttgaattg tccccacgcc 1020 gcgcccctgt agagaaatat aaaaggttag gatttgccac tgaggttctt ctttcatata 1080 cttcctttta aaatcttgct aggatacagt tctcacatca catccgaaca taaacaacaa 1140 tgtctgttat taatttcaca ggtagttctg gtccattggt gaaagtttgc ggcttgcaga 1200 gcacagaggc cgcagaatgt gctctagatt ccgatgctga cttgctgggt attatatgtg 1260 tgcccaatag aaagagaaca attgacccgg ttattgcaag gaaaatttca agtcttgtaa 1320 aagcatataa aaatagttca ggcactccga aatacttggt tggcgtgttt cgtaatcaac 1380 ctaaggagga tgttttggct ctggtcaatg attacggcat tgatatcgtc caactgcatg 1440 gagatgagtc gtggcaagaa taccaagagt tcctcggttt gccagttatt aaaagactcg 1500 tatttccaaa agactgcaac atactactca gtgcagcttc acagaaacct cattcgttta 1560 ttcccttgtt tgattcagaa gccggtggga caggtgaact tttggattgg aactcgattt 1620 ctgactgggt tggaaggcaa gagagccccg aaagcttaca ttttatgtta gctggtggac 1680 tgacgccaga aaatgttggt gatgcgctta gattaaatgg cgttattggt gttgatgtaa 1740 gcggaggtgt ggagacaaat ggtgtaaaag actctaacaa aatagcaaat ttcgtcaaaa 1800 atgctaagaa atagtcagta ctgacaataa aaagattctt gttttcaaga acttgtcatt 1860 tgtatagttt ttttatattg tagttgttct attttaatca aatgttagcg tgatttatat 1920 tttttttcgc ctcgacatca tctgcccaga tgcgaagtta agtgcgcaga aagtaatatc 1980 atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg tcgattcgat actaacgccg 2040 ccatccagtg tcgaaacgct atgatccaat atcaaaggaa actaggtttt gtaaaaaata 2100 ttttttatat taaaaaaata agttgattat attaaaaata tgtttaaaag ttaattaata 2160 tgtaagttaa aatgttcgaa ttaatacaag tgtgattttg catgtattta gtattttatt 2220 ttatttccta attctggggt gctaagcacc ccacgcgacc gcttatgcaa ctttgtaggc 2280 gcgcccaatt aagggttaag ccgctaaagg cattatccgc caagtacaat tttttactct 2340 tcgaagatag aaaatttgct gacattggta atacagtcaa attgcagtac tctgcgggtg 2400 tatacagaat agcagaatgg gcagacatta cgaatgcaca cggtgtggtg ggcccaggta 2460 ttgttagcgg tttgaagcag gcggcagaag aagtaacaaa ggaacctaga ggccttttga 2520 tgttagcaga attgtcatgc aagggctccc tatctactgg agaatatact aagggtactg 2580 ttgacattgc gaaaagcgac aaagattttg ttatcggctt tattgctcaa agagacatgg 2640 gtggaagaga tgaaggttac gattggttga ttatgacacc cggtgtgggt ttagatgaca 2700 agggagatgc attgggtcaa cagtatagaa ccgtggatga tgttgtctct acaggatctg 2760 acattattat tgttggaaga ggactatttg caaagggaag ggatgctaag gtagagggtg 2820 aacgttacag aaaagcaggc tgggaagcat atttgagaag atgcggccag caaaactaaa 2880 aaactgtatt ataagtaaat gcatgtatac taaactcaca aattagagct tcaatttaat 2940 tatatcagtt attaccc 2957 <210> 198 <211> 3253 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 198 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacacgttca ctgccggtgt caacacgtag ttgacacacg 420 tacattcgcc ggtggccact gtcaatacgt tgttgacacc aaaactatcc atttttaata 480 tattgtcacg gggtcggctt ttatcgcatg ttatttattt atttattaat agattcgata 540 gcccgtgtaa aattgaatgg tatagttgga ttcatttttc gaattattta tagaatattt 600 ttcctaatta ttattttcgt tgatattatt taatatctta atatataata cacatatacc 660 aaattattat tgttgaaata ttacacagtt ttatctttta tgtttgacag tcattcttca 720 acgtgcgtac attgtcgtag tcagtcgtag tcactagaat tgatattatt ttgtgtgtgt 780 ttttttaagt acatttaaaa ttgttcattt taatcctaca tagtgatagt atagtttagc 840 ttgcctcgtc cccgccgggt cacccggcca gcgacatgga ggcccagaat accctccttg 900 acagtcttga cgtgcgcagc tcaggggcat gatgtgactg tcgcccgtac atttagccca 960 tacatcccca tgtataatca tttgcatcca tacattttga tggccgcacg gcgcgaagca 1020 aaaattacgg ctcctcgctg cagaccagcg agcagggaaa cgctcccctc acagacgcgt 1080 tgaattgtcc ccacgccgcg cccctgtaga gaaatataaa aggttaggat ttgccactga 1140 ggttcttctt tcatatactt ccttttaaaa tcttgctagg atacagttct cacatcacat 1200 ccgaacataa acaacaatgt ctgttattaa tttcacaggt agttctggtc cattggtgaa 1260 agtttgcggc ttgcagagca cagaggccgc agaatgtgct ctagattccg atgctgactt 1320 gctgggtatt atatgtgtgc ccaatagaaa gagaacaatt gacccggtta ttgcaaggaa 1380 aatttcaagt cttgtaaaag catataaaaa tagttcaggc actccgaaat acttggttgg 1440 cgtgtttcgt aatcaaccta aggaggatgt tttggctctg gtcaatgatt acggcattga 1500 tatcgtccaa ctgcatggag atgagtcgtg gcaagaatac caagagttcc tcggtttgcc 1560 agttattaaa agactcgtat ttccaaaaga ctgcaacata ctactcagtg cagcttcaca 1620 gaaacctcat tcgtttattc ccttgtttga ttcagaagcc ggtgggacag gtgaactttt 1680 ggattggaac tcgatttctg actgggttgg aaggcaagag agccccgaaa gcttacattt 1740 tatgttagct ggtggactga cgccagaaaa tgttggtgat gcgcttagat taaatggcgt 1800 tattggtgtt gatgtaagcg gaggtgtgga gacaaatggt gtaaaagact ctaacaaaat 1860 agcaaatttc gtcaaaaatg ctaagaaata gtcagtactg acaataaaaa gattcttgtt 1920 ttcaagaact tgtcatttgt atagtttttt tatattgtag ttgttctatt ttaatcaaat 1980 gttagcgtga tttatatttt ttttcgcctc gacatcatct gcccagatgc gaagttaagt 2040 gcgcagaaag taatatcatg cgtcaatcgt atgtgaatgc tggtcgctat actgctgtcg 2100 attcgatact aacgccgcca tccagtgtcg aaacgctatg atccaatatc aaaggaatta 2160 aaaattatgt ttattgtttt atttatattt atacttattt gtaagttaaa aactacagtt 2220 taattcaata agtagtattt ttttatttta tttcatttta ttaaatatta aaaataaatc 2280 tatacaaaaa aaaagttgaa ttttcatttt acatttttgt gtaaccgctg tgttgtagta 2340 caaattgaaa aaaaccaaag tacttataaa ctcaatagta tcgtaatatt attgaaaaac 2400 ataattgtaa gtgtgatgta tgataattta tcaagtattt atttagatat aattgtggat 2460 tcttatttat tattagcatg aatcgggcgc gcaacgccgg tgtcaacacg tagttgacag 2520 tatcagccga gactggtttt tggttacggc tacgcgcgcg ctaatgcata attcggtcgg 2580 cagtgaacgt gttaagccgc taaaggcatt atccgccaag tacaattttt tactcttcga 2640 agatagaaaa tttgctgaca ttggtaatac agtcaaattg cagtactctg cgggtgtata 2700 cagaatagca gaatgggcag acattacgaa tgcacacggt gtggtgggcc caggtattgt 2760 tagcggtttg aagcaggcgg cagaagaagt aacaaaggaa cctagaggcc ttttgatgtt 2820 agcagaattg tcatgcaagg gctccctatc tactggagaa tatactaagg gtactgttga 2880 cattgcgaaa agcgacaaag attttgttat cggctttatt gctcaaagag acatgggtgg 2940 aagagatgaa ggttacgatt ggttgattat gacacccggt gtgggtttag atgacaaggg 3000 agatgcattg ggtcaacagt atagaaccgt ggatgatgtt gtctctacag gatctgacat 3060 tattattgtt ggaagaggac tatttgcaaa gggaagggat gctaaggtag agggtgaacg 3120 ttacagaaaa gcaggctggg aagcatattt gagaagatgc ggccagcaaa actaaaaaac 3180 tgtattataa gtaaatgcat gtatactaaa ctcacaaatt agagcttcaa tttaattata 3240 tcagttatta ccc 3253 <210> 199 <211> 2849 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 199 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacactccac cgcacgcgcg tctactattg tagactgcag 420 aatttagtta cgcaatattt acaacattca tgtaagagaa gttgcctgtt ttcgtgtatt 480 cctcaaaaat gacaccctta acgtatttag ttggttttca aacgcggttg ctagtgtatc 540 gtcgagtttt tttgttattt ctacgattgt agagcacgcg tgttctcccg taactaattc 600 tgttaccgcg taagtatgca atttaagcgt tatttatggg tttttcgtta tgttacattt 660 ttaggtttag cttgcctcgt ccccgccggg tcacccggcc agcgacatgg aggcccagaa 720 taccctcctt gacagtcttg acgtgcgcag ctcaggggca tgatgtgact gtcgcccgta 780 catttagccc atacatcccc atgtataatc atttgcatcc atacattttg atggccgcac 840 ggcgcgaagc aaaaattacg gctcctcgct gcagaccagc gagcagggaa acgctcccct 900 cacagacgcg ttgaattgtc cccacgccgc gcccctgtag agaaatataa aaggttagga 960 tttgccactg aggttcttct ttcatatact tccttttaaa atcttgctag gatacagttc 1020 tcacatcaca tccgaacata aacaacaatg tctgttatta atttcacagg tagttctggt 1080 ccattggtga aagtttgcgg cttgcagagc acagaggccg cagaatgtgc tctagattcc 1140 gatgctgact tgctgggtat tatatgtgtg cccaatagaa agagaacaat tgacccggtt 1200 attgcaagga aaatttcaag tcttgtaaaa gcatataaaa atagttcagg cactccgaaa 1260 tacttggttg gcgtgtttcg taatcaacct aaggaggatg ttttggctct ggtcaatgat 1320 tacggcattg atatcgtcca actgcatgga gatgagtcgt ggcaagaata ccaagagttc 1380 ctcggtttgc cagttattaa aagactcgta tttccaaaag actgcaacat actactcagt 1440 gcagcttcac agaaacctca ttcgtttatt cccttgtttg attcagaagc cggtgggaca 1500 ggtgaacttt tggattggaa ctcgatttct gactgggttg gaaggcaaga gagccccgaa 1560 agcttacatt ttatgttagc tggtggactg acgccagaaa atgttggtga tgcgcttaga 1620 ttaaatggcg ttattggtgt tgatgtaagc ggaggtgtgg agacaaatgg tgtaaaagac 1680 tctaacaaaa tagcaaattt cgtcaaaaat gctaagaaat agtcagtact gacaataaaa 1740 agattcttgt tttcaagaac ttgtcatttg tatagttttt ttatattgta gttgttctat 1800 tttaatcaaa tgttagcgtg atttatattt tttttcgcct cgacatcatc tgcccagatg 1860 cgaagttaag tgcgcagaaa gtaatatcat gcgtcaatcg tatgtgaatg ctggtcgcta 1920 tactgctgtc gattcgatac taacgccgcc atccagtgtc gaaacgctat gatccaatat 1980 caaaggactt gaagatatat tttattttac tccatactat accttatttt cttttgattt 2040 ctataaataa agttgttata agtatatcta atacttttta ttatcagaaa tggaaaataa 2100 ataaagattc taataagacg cgaatgttct actattgtag tacatgcgtg ttttgttgta 2160 tgaaaaaggg gcgcgtgcgg tggagtgtta agccgctaaa ggcattatcc gccaagtaca 2220 attttttact cttcgaagat agaaaatttg ctgacattgg taatacagtc aaattgcagt 2280 actctgcggg tgtatacaga atagcagaat gggcagacat tacgaatgca cacggtgtgg 2340 tgggcccagg tattgttagc ggtttgaagc aggcggcaga agaagtaaca aaggaaccta 2400 gaggcctttt gatgttagca gaattgtcat gcaagggctc cctatctact ggagaatata 2460 ctaagggtac tgttgacatt gcgaaaagcg acaaagattt tgttatcggc tttattgctc 2520 aaagagacat gggtggaaga gatgaaggtt acgattggtt gattatgaca cccggtgtgg 2580 gtttagatga caagggagat gcattgggtc aacagtatag aaccgtggat gatgttgtct 2640 ctacaggatc tgacattatt attgttggaa gaggactatt tgcaaaggga agggatgcta 2700 aggtagaggg tgaacgttac agaaaagcag gctgggaagc atatttgaga agatgcggcc 2760 agcaaaacta aaaaactgta ttataagtaa atgcatgtat actaaactca caaattagag 2820 cttcaattta attatatcag ttattaccc 2849 <210> 200 <211> 3253 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 200 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctagaa tgcacgactg gggtcgattt cgaccccagg 420 caaactttga actatatacg ctcctgttcg actaactctc taaaagtacg ggctacgtcg 480 ggcgcagcgt tagttgttcg ctggcagtga cgcagcaccg tcgcaaagcg tgcgtggggt 540 cgatattgac cccagttgtg agtttccgtt tgtgttttgt cacggtaagc taattttata 600 ttttttgcta gaatcaatat atttcatgta ttattacgta atctgagcat aaatagtcat 660 aaatattatt taagacaaaa tatctcacga cttagtcggt aaaaatcccg ttgcctacag 720 ataagattga cattttgcag aaagtttagc ttgcctcgtc cccgccgggt cacccggcca 780 gcgacatgga ggcccagaat accctccttg acagtcttga cgtgcgcagc tcaggggcat 840 gatgtgactg tcgcccgtac atttagccca tacatcccca tgtataatca tttgcatcca 900 tacattttga tggccgcacg gcgcgaagca aaaattacgg ctcctcgctg cagaccagcg 960 agcagggaaa cgctcccctc acagacgcgt tgaattgtcc ccacgccgcg cccctgtaga 1020 gaaatataaa aggttaggat ttgccactga ggttcttctt tcatatactt ccttttaaaa 1080 tcttgctagg atacagttct cacatcacat ccgaacataa acaacaatgt ctgttattaa 1140 tttcacaggt agttctggtc cattggtgaa agtttgcggc ttgcagagca cagaggccgc 1200 agaatgtgct ctagattccg atgctgactt gctgggtatt atatgtgtgc ccaatagaaa 1260 gagaacaatt gacccggtta ttgcaaggaa aatttcaagt cttgtaaaag catataaaaa 1320 tagttcaggc actccgaaat acttggttgg cgtgtttcgt aatcaaccta aggaggatgt 1380 tttggctctg gtcaatgatt acggcattga tatcgtccaa ctgcatggag atgagtcgtg 1440 gcaagaatac caagagttcc tcggtttgcc agttattaaa agactcgtat ttccaaaaga 1500 ctgcaacata ctactcagtg cagcttcaca gaaacctcat tcgtttattc ccttgtttga 1560 ttcagaagcc ggtgggacag gtgaactttt ggattggaac tcgatttctg actgggttgg 1620 aaggcaagag agccccgaaa gcttacattt tatgttagct ggtggactga cgccagaaaa 1680 tgttggtgat gcgcttagat taaatggcgt tattggtgtt gatgtaagcg gaggtgtgga 1740 gacaaatggt gtaaaagact ctaacaaaat agcaaatttc gtcaaaaatg ctaagaaata 1800 gtcagtactg acaataaaaa gattcttgtt ttcaagaact tgtcatttgt atagtttttt 1860 tatattgtag ttgttctatt ttaatcaaat gttagcgtga tttatatttt ttttcgcctc 1920 gacatcatct gcccagatgc gaagttaagt gcgcagaaag taatatcatg cgtcaatcgt 1980 atgtgaatgc tggtcgctat actgctgtcg attcgatact aacgccgcca tccagtgtcg 2040 aaacgctatg atccaatatc aaaggatgcg actaaataag tatttttcat tttttttcat 2100 attttttact attttgtatc aaattaaatt aaaataatac ttaaaataca attttttatg 2160 gttttttcat cgattttttc catatttcaa ctttgcgaat ttcttcattt ttataatctt 2220 aaataaatat actttttgaa cagaacataa cgatgacaat ttttttccaa ttgtctaatg 2280 tgtcctcttc aaagtttgaa ttttgaaaat tggttgatta caaaaaaaga tacaaatttt 2340 tgttttaaaa aagaggtttt tgctgatttt ctgcattttt cggtcttcaa atggattttt 2400 cactaactaa acttgagtaa aattaaattt atcgtatact attctctttt ttattaaaaa 2460 acgaagaaat ttatgtacta ttaaggccct ttatctctgt aggaccggtt ttacgatcaa 2520 aaaagcgttg agtcgatatt gaccccagtt atgagttaaa aggtaaaaaa aatgacttgt 2580 gcgttctagg gttaagccgc taaaggcatt atccgccaag tacaattttt tactcttcga 2640 agatagaaaa tttgctgaca ttggtaatac agtcaaattg cagtactctg cgggtgtata 2700 cagaatagca gaatgggcag acattacgaa tgcacacggt gtggtgggcc caggtattgt 2760 tagcggtttg aagcaggcgg cagaagaagt aacaaaggaa cctagaggcc ttttgatgtt 2820 agcagaattg tcatgcaagg gctccctatc tactggagaa tatactaagg gtactgttga 2880 cattgcgaaa agcgacaaag attttgttat cggctttatt gctcaaagag acatgggtgg 2940 aagagatgaa ggttacgatt ggttgattat gacacccggt gtgggtttag atgacaaggg 3000 agatgcattg ggtcaacagt atagaaccgt ggatgatgtt gtctctacag gatctgacat 3060 tattattgtt ggaagaggac tatttgcaaa gggaagggat gctaaggtag agggtgaacg 3120 ttacagaaaa gcaggctggg aagcatattt gagaagatgc ggccagcaaa actaaaaaac 3180 tgtattataa gtaaatgcat gtatactaaa ctcacaaatt agagcttcaa tttaattata 3240 tcagttatta ccc 3253 <210> 201 <211> 2927 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 201 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctacag tggtcgcgcg gatgacactt gtcatccacc 420 acttttaatt tgctgataga gttggtatag gtttaggtgg ggaactgtgg ttcccaatag 480 ctgcttatta tgtatacgca tgtggtatga acgagtagtt ttgaattgat ttttagtaat 540 aaggctccta gtgtgagtta aagttacccg gaggacaggt gtcatccacg cgaccattga 600 cgttagtgtt ggtttcatag acactgtgta tattttccac catttctcat cgctgaaggt 660 accaatgcag tttatatttt acattagttc aacacagcat tttaggatcc atattggagg 720 aaattttcag ctgtttagct tgcctcgtcc ccgccgggtc acccggccag cgacatggag 780 gcccagaata ccctccttga cagtcttgac gtgcgcagct caggggcatg atgtgactgt 840 cgcccgtaca tttagcccat acatccccat gtataatcat ttgcatccat acattttgat 900 ggccgcacgg cgcgaagcaa aaattacggc tcctcgctgc agaccagcga gcagggaaac 960 gctcccctca cagacgcgtt gaattgtccc cacgccgcgc ccctgtagag aaatataaaa 1020 ggttaggatt tgccactgag gttcttcttt catatacttc cttttaaaat cttgctagga 1080 tacagttctc acatcacatc cgaacataaa caacaatgtc tgttattaat ttcacaggta 1140 gttctggtcc attggtgaaa gtttgcggct tgcagagcac agaggccgca gaatgtgctc 1200 tagattccga tgctgacttg ctgggtatta tatgtgtgcc caatagaaag agaacaattg 1260 acccggttat tgcaaggaaa atttcaagtc ttgtaaaagc atataaaaat agttcaggca 1320 ctccgaaata cttggttggc gtgtttcgta atcaacctaa ggaggatgtt ttggctctgg 1380 tcaatgatta cggcattgat atcgtccaac tgcatggaga tgagtcgtgg caagaatacc 1440 aagagttcct cggtttgcca gttattaaaa gactcgtatt tccaaaagac tgcaacatac 1500 tactcagtgc agcttcacag aaacctcatt cgtttattcc cttgtttgat tcagaagccg 1560 gtgggacagg tgaacttttg gattggaact cgatttctga ctgggttgga aggcaagaga 1620 gccccgaaag cttacatttt atgttagctg gtggactgac gccagaaaat gttggtgatg 1680 cgcttagatt aaatggcgtt attggtgttg atgtaagcgg aggtgtggag acaaatggtg 1740 taaaagactc taacaaaata gcaaatttcg tcaaaaatgc taagaaatag tcagtactga 1800 caataaaaag attcttgttt tcaagaactt gtcatttgta tagttttttt atattgtagt 1860 tgttctattt taatcaaatg ttagcgtgat ttatattttt tttcgcctcg acatcatctg 1920 cccagatgcg aagttaagtg cgcagaaagt aatatcatgc gtcaatcgta tgtgaatgct 1980 ggtcgctata ctgctgtcga ttcgatacta acgccgccat ccagtgtcga aacgctatga 2040 tccaatatca aaggacttgt aaaataacta tcatgtatgt aataaaaata ttttttgagt 2100 tctgttggta attaatactt tctctatacc atcagtaata aattctgatt accttgtaac 2160 acaaaaagat attaaatccg taaagtggcc ctaaacaaac tgtggatgac cactgtcatc 2220 cgcgcgatta tgcccgtcct aaacattgac gcgaccgctg cagggttaag ccgctaaagg 2280 cattatccgc caagtacaat tttttactct tcgaagatag aaaatttgct gacattggta 2340 atacagtcaa attgcagtac tctgcgggtg tatacagaat agcagaatgg gcagacatta 2400 cgaatgcaca cggtgtggtg ggcccaggta ttgttagcgg tttgaagcag gcggcagaag 2460 aagtaacaaa ggaacctaga ggccttttga tgttagcaga attgtcatgc aagggctccc 2520 tatctactgg agaatatact aagggtactg ttgacattgc gaaaagcgac aaagattttg 2580 ttatcggctt tattgctcaa agagacatgg gtggaagaga tgaaggttac gattggttga 2640 ttatgacacc cggtgtgggt ttagatgaca agggagatgc attgggtcaa cagtatagaa 2700 ccgtggatga tgttgtctct acaggatctg acattattat tgttggaaga ggactatttg 2760 caaagggaag ggatgctaag gtagagggtg aacgttacag aaaagcaggc tgggaagcat 2820 atttgagaag atgcggccag caaaactaaa aaactgtatt ataagtaaat gcatgtatac 2880 taaactcaca aattagagct tcaatttaat tatatcagtt attaccc 2927 <210> 202 <211> 2797 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 202 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacccgcgag aactcgcacc gggtataaca tgcccgatcc 420 attttcattc aaagtttttc ttactttctt ctattggaac agagccagga tttcgtgtag 480 ctgtattcaa ggtcacattc tttcactagg ggaaaagctg gttttgttct ataaatagat 540 tttcaggaac aggtgtcggg ggtatgtcat acccgtgcta gtcctggcgt cagtcggatc 600 attccttctt tttctctcag tttagtgaat tgtttagctt gcctcgtccc cgccgggtca 660 cccggccagc gacatggagg cccagaatac cctccttgac agtcttgacg tgcgcagctc 720 aggggcatga tgtgactgtc gcccgtacat ttagcccata catccccatg tataatcatt 780 tgcatccata cattttgatg gccgcacggc gcgaagcaaa aattacggct cctcgctgca 840 gaccagcgag cagggaaacg ctcccctcac agacgcgttg aattgtcccc acgccgcgcc 900 cctgtagaga aatataaaag gttaggattt gccactgagg ttcttctttc atatacttcc 960 ttttaaaatc ttgctaggat acagttctca catcacatcc gaacataaac aacaatgtct 1020 gttattaatt tcacaggtag ttctggtcca ttggtgaaag tttgcggctt gcagagcaca 1080 gaggccgcag aatgtgctct agattccgat gctgacttgc tgggtattat atgtgtgccc 1140 aatagaaaga gaacaattga cccggttatt gcaaggaaaa tttcaagtct tgtaaaagca 1200 tataaaaata gttcaggcac tccgaaatac ttggttggcg tgtttcgtaa tcaacctaag 1260 gaggatgttt tggctctggt caatgattac ggcattgata tcgtccaact gcatggagat 1320 gagtcgtggc aagaatacca agagttcctc ggtttgccag ttattaaaag actcgtattt 1380 ccaaaagact gcaacatact actcagtgca gcttcacaga aacctcattc gtttattccc 1440 ttgtttgatt cagaagccgg tgggacaggt gaacttttgg attggaactc gatttctgac 1500 tgggttggaa ggcaagagag ccccgaaagc ttacatttta tgttagctgg tggactgacg 1560 ccagaaaatg ttggtgatgc gcttagatta aatggcgtta ttggtgttga tgtaagcgga 1620 ggtgtggaga caaatggtgt aaaagactct aacaaaatag caaatttcgt caaaaatgct 1680 aagaaatagt cagtactgac aataaaaaga ttcttgtttt caagaacttg tcatttgtat 1740 agttttttta tattgtagtt gttctatttt aatcaaatgt tagcgtgatt tatatttttt 1800 ttcgcctcga catcatctgc ccagatgcga agttaagtgc gcagaaagta atatcatgcg 1860 tcaatcgtat gtgaatgctg gtcgctatac tgctgtcgat tcgatactaa cgccgccatc 1920 cagtgtcgaa acgctatgat ccaatatcaa aggaacatgt gagtatgtat ttttaaactc 1980 aataaaattc tttaatgtat tattttgtaa tgtttaatta tgtaaggctt gcttataaac 2040 agtattattt catatttagg tagcagaaat gaactagggt atgagatacc cagcgcgagt 2100 tctcgcgttg gaaaacggtt gcgtgttctc ccgggttaag ccgctaaagg cattatccgc 2160 caagtacaat tttttactct tcgaagatag aaaatttgct gacattggta atacagtcaa 2220 attgcagtac tctgcgggtg tatacagaat agcagaatgg gcagacatta cgaatgcaca 2280 cggtgtggtg ggcccaggta ttgttagcgg tttgaagcag gcggcagaag aagtaacaaa 2340 ggaacctaga ggccttttga tgttagcaga attgtcatgc aagggctccc tatctactgg 2400 agaatatact aagggtactg ttgacattgc gaaaagcgac aaagattttg ttatcggctt 2460 tattgctcaa agagacatgg gtggaagaga tgaaggttac gattggttga ttatgacacc 2520 cggtgtgggt ttagatgaca agggagatgc attgggtcaa cagtatagaa ccgtggatga 2580 tgttgtctct acaggatctg acattattat tgttggaaga ggactatttg caaagggaag 2640 ggatgctaag gtagagggtg aacgttacag aaaagcaggc tgggaagcat atttgagaag 2700 atgcggccag caaaactaaa aaactgtatt ataagtaaat gcatgtatac taaactcaca 2760 aattagagct tcaatttaat tatatcagtt attaccc 2797 <210> 203 <211> 2954 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 203 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctagat aactaaacat tcgtccgctc gacgacgcgc 420 tatgccgcga aattgaagtt tacctattat tccgcgtccc ccgcccccgc cgctttttct 480 agcttcctga tttgcaaaat agtgcatcgc gtgacacgct cgaggtcaca cgacaattag 540 gtcgaaagtt acaggaattt cgtcgtccgc tcgacgaaag tttagtaatt acgtaagttt 600 ggcaaaggta agtgaatgaa gtattttttt ataattattt tttaattctt tatagtgata 660 acgtaaggtt tatttaaatt tattactttt atagttattt agccaattgt tataaattcc 720 ttgttattgc tgaaaaattt gcctgtttta gtcaaaattt attaactttt cgatcgtttt 780 ttaggcctag tttagcttgc ctcgtccccg ccgggtcacc cggccagcga catggaggcc 840 cagaataccc tccttgacag tcttgacgtg cgcagctcag gggcatgatg tgactgtcgc 900 ccgtacattt agcccataca tccccatgta taatcatttg catccataca ttttgatggc 960 cgcacggcgc gaagcaaaaa ttacggctcc tcgctgcaga ccagcgagca gggaaacgct 1020 cccctcacag acgcgttgaa ttgtccccac gccgcgcccc tgtagagaaa tataaaaggt 1080 taggatttgc cactgaggtt cttctttcat atacttcctt ttaaaatctt gctaggatac 1140 agttctcaca tcacatccga acataaacaa caatgtctgt tattaatttc acaggtagtt 1200 ctggtccatt ggtgaaagtt tgcggcttgc agagcacaga ggccgcagaa tgtgctctag 1260 attccgatgc tgacttgctg ggtattatat gtgtgcccaa tagaaagaga acaattgacc 1320 cggttattgc aaggaaaatt tcaagtcttg taaaagcata taaaaatagt tcaggcactc 1380 cgaaatactt ggttggcgtg tttcgtaatc aacctaagga ggatgttttg gctctggtca 1440 atgattacgg cattgatatc gtccaactgc atggagatga gtcgtggcaa gaataccaag 1500 agttcctcgg tttgccagtt attaaaagac tcgtatttcc aaaagactgc aacatactac 1560 tcagtgcagc ttcacagaaa cctcattcgt ttattccctt gtttgattca gaagccggtg 1620 ggacaggtga acttttggat tggaactcga tttctgactg ggttggaagg caagagagcc 1680 ccgaaagctt acattttatg ttagctggtg gactgacgcc agaaaatgtt ggtgatgcgc 1740 ttagattaaa tggcgttatt ggtgttgatg taagcggagg tgtggagaca aatggtgtaa 1800 aagactctaa caaaatagca aatttcgtca aaaatgctaa gaaatagtca gtactgacaa 1860 taaaaagatt cttgttttca agaacttgtc atttgtatag tttttttata ttgtagttgt 1920 tctattttaa tcaaatgtta gcgtgattta tatttttttt cgcctcgaca tcatctgccc 1980 agatgcgaag ttaagtgcgc agaaagtaat atcatgcgtc aatcgtatgt gaatgctggt 2040 cgctatactg ctgtcgattc gatactaacg ccgccatcca gtgtcgaaac gctatgatcc 2100 aatatcaaag gatcatcttt cactaagtaa ttttgttcct atttagtaga taagtaacac 2160 ataattattg tgatattcaa aacttaagag gtttaataaa taataataaa aaaaaaatgg 2220 tttttatttc gtagtctgct cgacgaatgt ttagttatta cgtaaccgtg aatatagttt 2280 agtagtctag ggttaagccg ctaaaggcat tatccgccaa gtacaatttt ttactcttcg 2340 aagatagaaa atttgctgac attggtaata cagtcaaatt gcagtactct gcgggtgtat 2400 acagaatagc agaatgggca gacattacga atgcacacgg tgtggtgggc ccaggtattg 2460 ttagcggttt gaagcaggcg gcagaagaag taacaaagga acctagaggc cttttgatgt 2520 tagcagaatt gtcatgcaag ggctccctat ctactggaga atatactaag ggtactgttg 2580 acattgcgaa aagcgacaaa gattttgtta tcggctttat tgctcaaaga gacatgggtg 2640 gaagagatga aggttacgat tggttgatta tgacacccgg tgtgggttta gatgacaagg 2700 gagatgcatt gggtcaacag tatagaaccg tggatgatgt tgtctctaca ggatctgaca 2760 ttattattgt tggaagagga ctatttgcaa agggaaggga tgctaaggta gagggtgaac 2820 gttacagaaa agcaggctgg gaagcatatt tgagaagatg cggccagcaa aactaaaaaa 2880 ctgtattata agtaaatgca tgtatactaa actcacaaat tagagcttca atttaattat 2940 atcagttatt accc 2954 <210> 204 <211> 3065 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 204 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctagaa gcccaatcta cgtcattctg acgtgtatgt 420 cgccgaaaat actctgtctc tttctcctgc acgatcggat tgccgcgaac gctcgattca 480 acccagttgg cgccgagatc tattggagga ctgcggcgtt gattcggtaa gtcccgccat 540 tttgtcatag taacagtatt gcacgtcagc ttgacgtata tttgggcttt gtgttatttt 600 tgtaaatttt caacgttagt ttattattgc atctttttgt tacattactg gtttatttgc 660 atgtattact caaatattat ttttatttta gcgtagaaaa tacagcctag tttagcttgc 720 ctcgtccccg ccgggtcacc cggccagcga catggaggcc cagaataccc tccttgacag 780 tcttgacgtg cgcagctcag gggcatgatg tgactgtcgc ccgtacattt agcccataca 840 tccccatgta taatcatttg catccataca ttttgatggc cgcacggcgc gaagcaaaaa 900 ttacggctcc tcgctgcaga ccagcgagca gggaaacgct cccctcacag acgcgttgaa 960 ttgtccccac gccgcgcccc tgtagagaaa tataaaaggt taggatttgc cactgaggtt 1020 cttctttcat atacttcctt ttaaaatctt gctaggatac agttctcaca tcacatccga 1080 acataaacaa caatgtctgt tattaatttc acaggtagtt ctggtccatt ggtgaaagtt 1140 tgcggcttgc agagcacaga ggccgcagaa tgtgctctag attccgatgc tgacttgctg 1200 ggtattatat gtgtgcccaa tagaaagaga acaattgacc cggttattgc aaggaaaatt 1260 tcaagtcttg taaaagcata taaaaatagt tcaggcactc cgaaatactt ggttggcgtg 1320 tttcgtaatc aacctaagga ggatgttttg gctctggtca atgattacgg cattgatatc 1380 gtccaactgc atggagatga gtcgtggcaa gaataccaag agttcctcgg tttgccagtt 1440 attaaaagac tcgtatttcc aaaagactgc aacatactac tcagtgcagc ttcacagaaa 1500 cctcattcgt ttattccctt gtttgattca gaagccggtg ggacaggtga acttttggat 1560 tggaactcga tttctgactg ggttggaagg caagagagcc ccgaaagctt acattttatg 1620 ttagctggtg gactgacgcc agaaaatgtt ggtgatgcgc ttagattaaa tggcgttatt 1680 ggtgttgatg taagcggagg tgtggagaca aatggtgtaa aagactctaa caaaatagca 1740 aatttcgtca aaaatgctaa gaaatagtca gtactgacaa taaaaagatt cttgttttca 1800 agaacttgtc atttgtatag tttttttata ttgtagttgt tctattttaa tcaaatgtta 1860 gcgtgattta tatttttttt cgcctcgaca tcatctgccc agatgcgaag ttaagtgcgc 1920 agaaagtaat atcatgcgtc aatcgtatgt gaatgctggt cgctatactg ctgtcgattc 1980 gatactaacg ccgccatcca gtgtcgaaac gctatgatcc aatatcaaag gatcatcaga 2040 ctgttttttt tgtatttgca ttatatatta tattctaaag ttgatttaat tctaagaaaa 2100 acattaaaat aagtttcttt ttgtaaaatt taattaatta taagaaaaag tttaagttga 2160 tctcattttt tataaaaatt tgcaatgttt ccaaagttat tattgtaaaa gaataaataa 2220 aagtaaactg agttttaatt gatgttttat tatatcatta tactatatat tacttaaata 2280 aaacaataac tgaatgtatt tctaaaagga atcactagaa aatatagtga tcaaaaattt 2340 acacgtcatt tttgcgtatg attgggcttt ataggttcta aaaatatgat tgggcctcta 2400 gggttaagcc gctaaaggca ttatccgcca agtacaattt tttactcttc gaagatagaa 2460 aatttgctga cattggtaat acagtcaaat tgcagtactc tgcgggtgta tacagaatag 2520 cagaatgggc agacattacg aatgcacacg gtgtggtggg cccaggtatt gttagcggtt 2580 tgaagcaggc ggcagaagaa gtaacaaagg aacctagagg ccttttgatg ttagcagaat 2640 tgtcatgcaa gggctcccta tctactggag aatatactaa gggtactgtt gacattgcga 2700 aaagcgacaa agattttgtt atcggcttta ttgctcaaag agacatgggt ggaagagatg 2760 aaggttacga ttggttgatt atgacacccg gtgtgggttt agatgacaag ggagatgcat 2820 tgggtcaaca gtatagaacc gtggatgatg ttgtctctac aggatctgac attattattg 2880 ttggaagagg actatttgca aagggaaggg atgctaaggt agagggtgaa cgttacagaa 2940 aagcaggctg ggaagcatat ttgagaagat gcggccagca aaactaaaaa actgtattat 3000 aagtaaatgc atgtatacta aactcacaaa ttagagcttc aatttaatta tatcagttat 3060 taccc 3065 <210> 205 <211> 3323 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 205 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctcaaa tggtttttgg ggtccattgg accccagagg 420 caaattagaa accatttgca gggggcatgt gtacaatagc aggccaatat ttttggagaa 480 ttactttttc tatggctttt ctatgcccat agaaactcaa ttgtgtgaca ggtttaatat 540 cttgaataat tggacttatt cggttgaatg aattctgggg tccaagggac cccagacaag 600 caagcccata atattgttgt gatatctatg gttgatgccc agtcatataa atatgattcc 660 acaaagcaac tctcacgact attttatgtc tgctgcctac cgcaactgac ttgtgtgttc 720 taacggcaat cagcttcagt tgataagttc aactatcgcg tacaactctg gcaactttgt 780 caatccgcca ctgaaagcgc tgccgacact ggtttagctt gcctcgtccc cgccgggtca 840 cccggccagc gacatggagg cccagaatac cctccttgac agtcttgacg tgcgcagctc 900 aggggcatga tgtgactgtc gcccgtacat ttagcccata catccccatg tataatcatt 960 tgcatccata cattttgatg gccgcacggc gcgaagcaaa aattacggct cctcgctgca 1020 gaccagcgag cagggaaacg ctcccctcac agacgcgttg aattgtcccc acgccgcgcc 1080 cctgtagaga aatataaaag gttaggattt gccactgagg ttcttctttc atatacttcc 1140 ttttaaaatc ttgctaggat acagttctca catcacatcc gaacataaac aacaatgtct 1200 gttattaatt tcacaggtag ttctggtcca ttggtgaaag tttgcggctt gcagagcaca 1260 gaggccgcag aatgtgctct agattccgat gctgacttgc tgggtattat atgtgtgccc 1320 aatagaaaga gaacaattga cccggttatt gcaaggaaaa tttcaagtct tgtaaaagca 1380 tataaaaata gttcaggcac tccgaaatac ttggttggcg tgtttcgtaa tcaacctaag 1440 gaggatgttt tggctctggt caatgattac ggcattgata tcgtccaact gcatggagat 1500 gagtcgtggc aagaatacca agagttcctc ggtttgccag ttattaaaag actcgtattt 1560 ccaaaagact gcaacatact actcagtgca gcttcacaga aacctcattc gtttattccc 1620 ttgtttgatt cagaagccgg tgggacaggt gaacttttgg attggaactc gatttctgac 1680 tgggttggaa ggcaagagag ccccgaaagc ttacatttta tgttagctgg tggactgacg 1740 ccagaaaatg ttggtgatgc gcttagatta aatggcgtta ttggtgttga tgtaagcgga 1800 ggtgtggaga caaatggtgt aaaagactct aacaaaatag caaatttcgt caaaaatgct 1860 aagaaatagt cagtactgac aataaaaaga ttcttgtttt caagaacttg tcatttgtat 1920 agttttttta tattgtagtt gttctatttt aatcaaatgt tagcgtgatt tatatttttt 1980 ttcgcctcga catcatctgc ccagatgcga agttaagtgc gcagaaagta atatcatgcg 2040 tcaatcgtat gtgaatgctg gtcgctatac tgctgtcgat tcgatactaa cgccgccatc 2100 cagtgtcgaa acgctatgat ccaatatcaa aggacttgct gtacgagcat catttctgct 2160 atttcaaagt tattacaatt cagaacttgc tacaaaattg cctttaacac ttgagcaaga 2220 tgagctgata gcataactgg ctataataca acatatacat accatatata catattacat 2280 acttataata agtaatctca aaaatttaat ctcaaatctc aaaatctaaa ttttccataa 2340 cttatcataa gcacagagct atgtgcaagt tctgattgta cactttttgc agcttctttt 2400 aattgctcag catcatgaat ttgtacttac atgtaaatat gactatcgcc taattttcat 2460 gtaactgtca tctgtgtgca aacacctgtt ctgtgctttg caaacacctg tacttaataa 2520 agtcaaataa taattaatat taaaattaat agtcaaataa actacacaaa taatctgttg 2580 tgctcagcat cagattctga atggggtcca ttggacccca gaaaaaagaa acagactatt 2640 ttttctttaa ctgtttgagg gttaagccgc taaaggcatt atccgccaag tacaattttt 2700 tactcttcga agatagaaaa tttgctgaca ttggtaatac agtcaaattg cagtactctg 2760 cgggtgtata cagaatagca gaatgggcag acattacgaa tgcacacggt gtggtgggcc 2820 caggtattgt tagcggtttg aagcaggcgg cagaagaagt aacaaaggaa cctagaggcc 2880 ttttgatgtt agcagaattg tcatgcaagg gctccctatc tactggagaa tatactaagg 2940 gtactgttga cattgcgaaa agcgacaaag attttgttat cggctttatt gctcaaagag 3000 acatgggtgg aagagatgaa ggttacgatt ggttgattat gacacccggt gtgggtttag 3060 atgacaaggg agatgcattg ggtcaacagt atagaaccgt ggatgatgtt gtctctacag 3120 gatctgacat tattattgtt ggaagaggac tatttgcaaa gggaagggat gctaaggtag 3180 agggtgaacg ttacagaaaa gcaggctggg aagcatattt gagaagatgc ggccagcaaa 3240 actaaaaaac tgtattataa gtaaatgcat gtatactaaa ctcacaaatt agagcttcaa 3300 tttaattata tcagttatta ccc 3323 <210> 206 <211> 3436 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 206 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccagttaa ccgtgtttga cgactatatc cgtcatggag 420 atttggcaga attttgtgcc atgacgactt tatccgtcat gtgtaaaatt ttgttacaat 480 tcgatattta aattgtagtt ctggagaaaa ttaaatttta ttcctaaatt ttaatatgtt 540 taaaatgttc agaggtcaca acgaaatgaa acaagcaaat aaaaattata aataatttaa 600 gttgattcat aacggtctga gagctaactc gtgaacagtg cagttatatc tggatatttg 660 attatcccga ttttcatctt gatgtaccaa aaccaaaaaa aagtttatta gattcttaat 720 ttagattctg tattcttttt tatactagat tctctatttg cggtgatacc tggaaacagc 780 tcatgtgcgc tatctcactc cttgtttgtt ttggatcagg caatttttgt tgctattcag 840 cgcagttcta ggacttatcg gggatggaga tgaaacggtt gatttttatc agttgtccga 900 gaattcgtaa acgggggcca cccggatata ttgttagcct cacatcttgt gcaaacttta 960 gcgcaggccg cgattagata tccccactta ggtttattca ctcttccgcg gtttactaga 1020 ctctaaccca cgtttgtcat ttcaattttt gaacgtgaac gatgcagtgc atttcagtgt 1080 gtctgaaata gtcagtgaat cgtgccaagt catataaagt gcaatgtaag tgtttcaagt 1140 gtctaattat tatagttatc cagaaaactt tcgtaaccca ctattttttt attcttagct 1200 tattttatcc ccaaagttta gcttgcctcg tccccgccgg gtcacccggc cagcgacatg 1260 gaggcccaga ataccctcct tgacagtctt gacgtgcgca gctcaggggc atgatgtgac 1320 tgtcgcccgt acatttagcc catacatccc catgtataat catttgcatc catacatttt 1380 gatggccgca cggcgcgaag caaaaattac ggctcctcgc tgcagaccag cgagcaggga 1440 aacgctcccc tcacagacgc gttgaattgt ccccacgccg cgcccctgta gagaaatata 1500 aaaggttagg atttgccact gaggttcttc tttcatatac ttccttttaa aatcttgcta 1560 ggatacagtt ctcacatcac atccgaacat aaacaacaat gtctgttatt aatttcacag 1620 gtagttctgg tccattggtg aaagtttgcg gcttgcagag cacagaggcc gcagaatgtg 1680 ctctagattc cgatgctgac ttgctgggta ttatatgtgt gcccaataga aagagaacaa 1740 ttgacccggt tattgcaagg aaaatttcaa gtcttgtaaa agcatataaa aatagttcag 1800 gcactccgaa atacttggtt ggcgtgtttc gtaatcaacc taaggaggat gttttggctc 1860 tggtcaatga ttacggcatt gatatcgtcc aactgcatgg agatgagtcg tggcaagaat 1920 accaagagtt cctcggtttg ccagttatta aaagactcgt atttccaaaa gactgcaaca 1980 tactactcag tgcagcttca cagaaacctc attcgtttat tcccttgttt gattcagaag 2040 ccggtgggac aggtgaactt ttggattgga actcgatttc tgactgggtt ggaaggcaag 2100 agagccccga aagcttacat tttatgttag ctggtggact gacgccagaa aatgttggtg 2160 atgcgcttag attaaatggc gttattggtg ttgatgtaag cggaggtgtg gagacaaatg 2220 gtgtaaaaga ctctaacaaa atagcaaatt tcgtcaaaaa tgctaagaaa tagtcagtac 2280 tgacaataaa aagattcttg ttttcaagaa cttgtcattt gtatagtttt tttatattgt 2340 agttgttcta ttttaatcaa atgttagcgt gatttatatt ttttttcgcc tcgacatcat 2400 ctgcccagat gcgaagttaa gtgcgcagaa agtaatatca tgcgtcaatc gtatgtgaat 2460 gctggtcgct atactgctgt cgattcgata ctaacgccgc catccagtgt cgaaacgcta 2520 tgatccaata tcaaaggaaa ttttgttcaa ctttttaaag ttttccattc attatgtata 2580 aatatatgtt cacattaagc gactgtacaa gtattacgaa taaaattgtt cattttctaa 2640 aatcaagtcg tcattttgac ccaatatttc aacagtgcca cttactctgt gtttgacgac 2700 tatacccgtc atcgcttgat tatcgcgaca cacactggtg cgcgctttgc ccacaggtcg 2760 ccacggttaa ctggttaagc cgctaaaggc attatccgcc aagtacaatt ttttactctt 2820 cgaagataga aaatttgctg acattggtaa tacagtcaaa ttgcagtact ctgcgggtgt 2880 atacagaata gcagaatggg cagacattac gaatgcacac ggtgtggtgg gcccaggtat 2940 tgttagcggt ttgaagcagg cggcagaaga agtaacaaag gaacctagag gccttttgat 3000 gttagcagaa ttgtcatgca agggctccct atctactgga gaatatacta agggtactgt 3060 tgacattgcg aaaagcgaca aagattttgt tatcggcttt attgctcaaa gagacatggg 3120 tggaagagat gaaggttacg attggttgat tatgacaccc ggtgtgggtt tagatgacaa 3180 gggagatgca ttgggtcaac agtatagaac cgtggatgat gttgtctcta caggatctga 3240 cattattatt gttggaagag gactatttgc aaagggaagg gatgctaagg tagagggtga 3300 acgttacaga aaagcaggct gggaagcata tttgagaaga tgcggccagc aaaactaaaa 3360 aactgtatta taagtaaatg catgtatact aaactcacaa attagagctt caatttaatt 3420 atatcagtta ttaccc 3436 <210> 207 <211> 2811 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 207 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccccttaa cctacgattt agattcgaag atgttaggcc 420 gaaattgtat acaagttcgc gcagcgttcg ggacgttcgc acgacttggg tacacgccga 480 tccgggcaat tgtaaacatg acggacatcg cccgtggtag agcggtcgcg gtttgtagat 540 agcacagaca agactcgtga tgtatttcta tcatctcttc gtatcgtaat tagtttccag 600 tcgttcttga tcgcattcgc acgtcgaaat ttacgttcat aaattctaga gaagcaaacc 660 cacaaggttt agcttgcctc gtccccgccg ggtcacccgg ccagcgacat ggaggcccag 720 aataccctcc ttgacagtct tgacgtgcgc agctcagggg catgatgtga ctgtcgcccg 780 tacatttagc ccatacatcc ccatgtataa tcatttgcat ccatacattt tgatggccgc 840 acggcgcgaa gcaaaaatta cggctcctcg ctgcagacca gcgagcaggg aaacgctccc 900 ctcacagacg cgttgaattg tccccacgcc gcgcccctgt agagaaatat aaaaggttag 960 gatttgccac tgaggttctt ctttcatata cttcctttta aaatcttgct aggatacagt 1020 tctcacatca catccgaaca taaacaacaa tgtctgttat taatttcaca ggtagttctg 1080 gtccattggt gaaagtttgc ggcttgcaga gcacagaggc cgcagaatgt gctctagatt 1140 ccgatgctga cttgctgggt attatatgtg tgcccaatag aaagagaaca attgacccgg 1200 ttattgcaag gaaaatttca agtcttgtaa aagcatataa aaatagttca ggcactccga 1260 aatacttggt tggcgtgttt cgtaatcaac ctaaggagga tgttttggct ctggtcaatg 1320 attacggcat tgatatcgtc caactgcatg gagatgagtc gtggcaagaa taccaagagt 1380 tcctcggttt gccagttatt aaaagactcg tatttccaaa agactgcaac atactactca 1440 gtgcagcttc acagaaacct cattcgttta ttcccttgtt tgattcagaa gccggtggga 1500 caggtgaact tttggattgg aactcgattt ctgactgggt tggaaggcaa gagagccccg 1560 aaagcttaca ttttatgtta gctggtggac tgacgccaga aaatgttggt gatgcgctta 1620 gattaaatgg cgttattggt gttgatgtaa gcggaggtgt ggagacaaat ggtgtaaaag 1680 actctaacaa aatagcaaat ttcgtcaaaa atgctaagaa atagtcagta ctgacaataa 1740 aaagattctt gttttcaaga acttgtcatt tgtatagttt ttttatattg tagttgttct 1800 attttaatca aatgttagcg tgatttatat tttttttcgc ctcgacatca tctgcccaga 1860 tgcgaagtta agtgcgcaga aagtaatatc atgcgtcaat cgtatgtgaa tgctggtcgc 1920 tatactgctg tcgattcgat actaacgccg ccatccagtg tcgaaacgct atgatccaat 1980 atcaaaggat tttgtatttt ggagttttgt ataaataaat attttgtaat acttgcgcct 2040 accacaatta ttgcatcaga ctgtaaatgc gtatcaaata ttccacgtaa tatttacatc 2100 gggcccgatc accgtacgcg ggctatgccc gtcattgtag gttaaggggt taagccgcta 2160 aaggcattat ccgccaagta caatttttta ctcttcgaag atagaaaatt tgctgacatt 2220 ggtaatacag tcaaattgca gtactctgcg ggtgtataca gaatagcaga atgggcagac 2280 attacgaatg cacacggtgt ggtgggccca ggtattgtta gcggtttgaa gcaggcggca 2340 gaagaagtaa caaaggaacc tagaggcctt ttgatgttag cagaattgtc atgcaagggc 2400 tccctatcta ctggagaata tactaagggt actgttgaca ttgcgaaaag cgacaaagat 2460 tttgttatcg gctttattgc tcaaagagac atgggtggaa gagatgaagg ttacgattgg 2520 ttgattatga cacccggtgt gggtttagat gacaagggag atgcattggg tcaacagtat 2580 agaaccgtgg atgatgttgt ctctacagga tctgacatta ttattgttgg aagaggacta 2640 tttgcaaagg gaagggatgc taaggtagag ggtgaacgtt acagaaaagc aggctgggaa 2700 gcatatttga gaagatgcgg ccagcaaaac taaaaaactg tattataagt aaatgcatgt 2760 atactaaact cacaaattag agcttcaatt taattatatc agttattacc c 2811 <210> 208 <211> 3039 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 208 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacctttaag tatggacgtg gagtctcaca ggctactcaa 420 tgtttacgtt ttcatagttt cacctatttc cccccgctcc ccgcgattga gcagctcagt 480 agcttttgtt ttagttgcca aactaccaac gagggaggag gttgtgtcgt ccggtgaatc 540 tcacgtgagt tataaccatc gaaaaattga ctggagcctg ttaggctaca cgtccattgt 600 tgtcatataa tatattttat aagggcgatt atgtttgttt cagattttgt agtacaaagt 660 ttagcttgcc tcgtccccgc cgggtcaccc ggccagcgac atggaggccc agaataccct 720 ccttgacagt cttgacgtgc gcagctcagg ggcatgatgt gactgtcgcc cgtacattta 780 gcccatacat ccccatgtat aatcatttgc atccatacat tttgatggcc gcacggcgcg 840 aagcaaaaat tacggctcct cgctgcagac cagcgagcag ggaaacgctc ccctcacaga 900 cgcgttgaat tgtccccacg ccgcgcccct gtagagaaat ataaaaggtt aggatttgcc 960 actgaggttc ttctttcata tacttccttt taaaatcttg ctaggataca gttctcacat 1020 cacatccgaa cataaacaac aatgtctgtt attaatttca caggtagttc tggtccattg 1080 gtgaaagttt gcggcttgca gagcacagag gccgcagaat gtgctctaga ttccgatgct 1140 gacttgctgg gtattatatg tgtgcccaat agaaagagaa caattgaccc ggttattgca 1200 aggaaaattt caagtcttgt aaaagcatat aaaaatagtt caggcactcc gaaatacttg 1260 gttggcgtgt ttcgtaatca acctaaggag gatgttttgg ctctggtcaa tgattacggc 1320 attgatatcg tccaactgca tggagatgag tcgtggcaag aataccaaga gttcctcggt 1380 ttgccagtta ttaaaagact cgtatttcca aaagactgca acatactact cagtgcagct 1440 tcacagaaac ctcattcgtt tattcccttg tttgattcag aagccggtgg gacaggtgaa 1500 cttttggatt ggaactcgat ttctgactgg gttggaaggc aagagagccc cgaaagctta 1560 cattttatgt tagctggtgg actgacgcca gaaaatgttg gtgatgcgct tagattaaat 1620 ggcgttattg gtgttgatgt aagcggaggt gtggagacaa atggtgtaaa agactctaac 1680 aaaatagcaa atttcgtcaa aaatgctaag aaatagtcag tactgacaat aaaaagattc 1740 ttgttttcaa gaacttgtca tttgtatagt ttttttatat tgtagttgtt ctattttaat 1800 caaatgttag cgtgatttat attttttttc gcctcgacat catctgccca gatgcgaagt 1860 taagtgcgca gaaagtaata tcatgcgtca atcgtatgtg aatgctggtc gctatactgc 1920 tgtcgattcg atactaacgc cgccatccag tgtcgaaacg ctatgatcca atatcaaagg 1980 aatttgcgtt attagactgt tgtcaaaatt ttttgtatta gttacctgaa gtaggttttt 2040 tgtgtttttg gttccttatc tattatattt taagaaaaaa agacaaattt tgttatagta 2100 ataagttgag ctgttttaaa tatctaaaaa tgtagcctaa gtaaattaag acttaaaagt 2160 gccataatta ttgatttttc acatttctat atttttgtta ataaaagatg attatataag 2220 catgttattt tattgctaaa taccttaact gtaatatcca atcagttttt aagcaacctt 2280 atatcaaatt ctcaaaaaaa aagtgttagc atataggagc ctgtgagact ccacgtccgc 2340 agtagtgtta agaaaaaatt acgtccatac ttaaaggtta agccgctaaa ggcattatcc 2400 gccaagtaca attttttact cttcgaagat agaaaatttg ctgacattgg taatacagtc 2460 aaattgcagt actctgcggg tgtatacaga atagcagaat gggcagacat tacgaatgca 2520 cacggtgtgg tgggcccagg tattgttagc ggtttgaagc aggcggcaga agaagtaaca 2580 aaggaaccta gaggcctttt gatgttagca gaattgtcat gcaagggctc cctatctact 2640 ggagaatata ctaagggtac tgttgacatt gcgaaaagcg acaaagattt tgttatcggc 2700 tttattgctc aaagagacat gggtggaaga gatgaaggtt acgattggtt gattatgaca 2760 cccggtgtgg gtttagatga caagggagat gcattgggtc aacagtatag aaccgtggat 2820 gatgttgtct ctacaggatc tgacattatt attgttggaa gaggactatt tgcaaaggga 2880 agggatgcta aggtagaggg tgaacgttac agaaaagcag gctgggaagc atatttgaga 2940 agatgcggcc agcaaaacta aaaaactgta ttataagtaa atgcatgtat actaaactca 3000 caaattagag cttcaattta attatatcag ttattaccc 3039 <210> 209 <211> 2979 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 209 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacccggcgt gattgacgct gggtcacagt gacccagcgc 420 gttttaaaac ggccatattt tttttatgag ttgatcattt gttttaaccg tttaagtagc 480 tggagttacg tcccccctct ccttagtcgg ccggtaagtt tagtgctacg tcggctgcgc 540 agcgagatac acgtgcgcca agtcaacgcg ggtaagtttg acccagcgtc atcgcgggcg 600 tcgtattttt gtggcattcc ttttttaatt aattttgttt agcttgcctc gtccccgccg 660 ggtcacccgg ccagcgacat ggaggcccag aataccctcc ttgacagtct tgacgtgcgc 720 agctcagggg catgatgtga ctgtcgcccg tacatttagc ccatacatcc ccatgtataa 780 tcatttgcat ccatacattt tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg 840 ctgcagacca gcgagcaggg aaacgctccc ctcacagacg cgttgaattg tccccacgcc 900 gcgcccctgt agagaaatat aaaaggttag gatttgccac tgaggttctt ctttcatata 960 cttcctttta aaatcttgct aggatacagt tctcacatca catccgaaca taaacaacaa 1020 tgtctgttat taatttcaca ggtagttctg gtccattggt gaaagtttgc ggcttgcaga 1080 gcacagaggc cgcagaatgt gctctagatt ccgatgctga cttgctgggt attatatgtg 1140 tgcccaatag aaagagaaca attgacccgg ttattgcaag gaaaatttca agtcttgtaa 1200 aagcatataa aaatagttca ggcactccga aatacttggt tggcgtgttt cgtaatcaac 1260 ctaaggagga tgttttggct ctggtcaatg attacggcat tgatatcgtc caactgcatg 1320 gagatgagtc gtggcaagaa taccaagagt tcctcggttt gccagttatt aaaagactcg 1380 tatttccaaa agactgcaac atactactca gtgcagcttc acagaaacct cattcgttta 1440 ttcccttgtt tgattcagaa gccggtggga caggtgaact tttggattgg aactcgattt 1500 ctgactgggt tggaaggcaa gagagccccg aaagcttaca ttttatgtta gctggtggac 1560 tgacgccaga aaatgttggt gatgcgctta gattaaatgg cgttattggt gttgatgtaa 1620 gcggaggtgt ggagacaaat ggtgtaaaag actctaacaa aatagcaaat ttcgtcaaaa 1680 atgctaagaa atagtcagta ctgacaataa aaagattctt gttttcaaga acttgtcatt 1740 tgtatagttt ttttatattg tagttgttct attttaatca aatgttagcg tgatttatat 1800 tttttttcgc ctcgacatca tctgcccaga tgcgaagtta agtgcgcaga aagtaatatc 1860 atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg tcgattcgat actaacgccg 1920 ccatccagtg tcgaaacgct atgatccaat atcaaaggat ttcttactat ttttaatata 1980 aaagtatttt tgatctctta tctataacct aagattgtta gttcctatta ttcgtaagaa 2040 aagtctatta aaattgttaa aagtagaaca aactaatgaa tgttaaattt tgaaccttga 2100 ttttgcatgt gttactttgg aaaccaataa aagtatgatt gatttaatat aatggcataa 2160 ttttatttta taacaagcgc agacgaccct ttttaacaaa taactaaaaa aaataagata 2220 acgtctttta tttcgcaaaa aatttacttt ataatgaggg gtaattgtga cccagtgtca 2280 ttgaccacgt aatttttttc acgtcaatca cgccgggtta agccgctaaa ggcattatcc 2340 gccaagtaca attttttact cttcgaagat agaaaatttg ctgacattgg taatacagtc 2400 aaattgcagt actctgcggg tgtatacaga atagcagaat gggcagacat tacgaatgca 2460 cacggtgtgg tgggcccagg tattgttagc ggtttgaagc aggcggcaga agaagtaaca 2520 aaggaaccta gaggcctttt gatgttagca gaattgtcat gcaagggctc cctatctact 2580 ggagaatata ctaagggtac tgttgacatt gcgaaaagcg acaaagattt tgttatcggc 2640 tttattgctc aaagagacat gggtggaaga gatgaaggtt acgattggtt gattatgaca 2700 cccggtgtgg gtttagatga caagggagat gcattgggtc aacagtatag aaccgtggat 2760 gatgttgtct ctacaggatc tgacattatt attgttggaa gaggactatt tgcaaaggga 2820 agggatgcta aggtagaggg tgaacgttac agaaaagcag gctgggaagc atatttgaga 2880 agatgcggcc agcaaaacta aaaaactgta ttataagtaa atgcatgtat actaaactca 2940 caaattagag cttcaattta attatatcag ttattaccc 2979 <210> 210 <211> 2920 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 210 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccctggaa tactataccg gggtactgga ttccccgggc 420 catttagttt ttctgatttt caggagatgg cagcacttat ctgattgtgc ttccaggtat 480 tctcctaact cttaagcatc tattcagttg caggtttgaa cttgttctaa gtggttgtgt 540 tttgtggtat cgctgtcttg gggcagtcaa ttccccagtg tagtgttcat gtaagtataa 600 caaattatag cttttctatc ttctataatt gagaactgat tattgatatt tattataagt 660 tgtataatgc ttttttataa ttaattatta attaataatg taaagttgat taattaatca 720 taataattgc attatttctt aattacagct ctccaaagtt tagcttgcct cgtccccgcc 780 gggtcacccg gccagcgaca tggaggccca gaataccctc cttgacagtc ttgacgtgcg 840 cagctcaggg gcatgatgtg actgtcgccc gtacatttag cccatacatc cccatgtata 900 atcatttgca tccatacatt ttgatggccg cacggcgcga agcaaaaatt acggctcctc 960 gctgcagacc agcgagcagg gaaacgctcc cctcacagac gcgttgaatt gtccccacgc 1020 cgcgcccctg tagagaaata taaaaggtta ggatttgcca ctgaggttct tctttcatat 1080 acttcctttt aaaatcttgc taggatacag ttctcacatc acatccgaac ataaacaaca 1140 atgtctgtta ttaatttcac aggtagttct ggtccattgg tgaaagtttg cggcttgcag 1200 agcacagagg ccgcagaatg tgctctagat tccgatgctg acttgctggg tattatatgt 1260 gtgcccaata gaaagagaac aattgacccg gttattgcaa ggaaaatttc aagtcttgta 1320 aaagcatata aaaatagttc aggcactccg aaatacttgg ttggcgtgtt tcgtaatcaa 1380 cctaaggagg atgttttggc tctggtcaat gattacggca ttgatatcgt ccaactgcat 1440 ggagatgagt cgtggcaaga ataccaagag ttcctcggtt tgccagttat taaaagactc 1500 gtatttccaa aagactgcaa catactactc agtgcagctt cacagaaacc tcattcgttt 1560 attcccttgt ttgattcaga agccggtggg acaggtgaac ttttggattg gaactcgatt 1620 tctgactggg ttggaaggca agagagcccc gaaagcttac attttatgtt agctggtgga 1680 ctgacgccag aaaatgttgg tgatgcgctt agattaaatg gcgttattgg tgttgatgta 1740 agcggaggtg tggagacaaa tggtgtaaaa gactctaaca aaatagcaaa tttcgtcaaa 1800 aatgctaaga aatagtcagt actgacaata aaaagattct tgttttcaag aacttgtcat 1860 ttgtatagtt tttttatatt gtagttgttc tattttaatc aaatgttagc gtgatttata 1920 ttttttttcg cctcgacatc atctgcccag atgcgaagtt aagtgcgcag aaagtaatat 1980 catgcgtcaa tcgtatgtga atgctggtcg ctatactgct gtcgattcga tactaacgcc 2040 gccatccagt gtcgaaacgc tatgatccaa tatcaaagga aggttattgt agtggaacag 2100 aatcctgtta atgtagtagt aagtattgta tttacatatt atcattaaag aaagtgtgag 2160 tttttacgat attattttta attattattt tccttgtggg gcatctagtt ccccagtgta 2220 gtactagtgt cgccagcaac aactgtagta ttccagggtt aagccgctaa aggcattatc 2280 cgccaagtac aattttttac tcttcgaaga tagaaaattt gctgacattg gtaatacagt 2340 caaattgcag tactctgcgg gtgtatacag aatagcagaa tgggcagaca ttacgaatgc 2400 acacggtgtg gtgggcccag gtattgttag cggtttgaag caggcggcag aagaagtaac 2460 aaaggaacct agaggccttt tgatgttagc agaattgtca tgcaagggct ccctatctac 2520 tggagaatat actaagggta ctgttgacat tgcgaaaagc gacaaagatt ttgttatcgg 2580 ctttattgct caaagagaca tgggtggaag agatgaaggt tacgattggt tgattatgac 2640 acccggtgtg ggtttagatg acaagggaga tgcattgggt caacagtata gaaccgtgga 2700 tgatgttgtc tctacaggat ctgacattat tattgttgga agaggactat ttgcaaaggg 2760 aagggatgct aaggtagagg gtgaacgtta cagaaaagca ggctgggaag catatttgag 2820 aagatgcggc cagcaaaact aaaaaactgt attataagta aatgcatgta tactaaactc 2880 acaaattaga gcttcaattt aattatatca gttattaccc 2920 <210> 211 <211> 3091 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 211 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacccggcat ccgacacatg gggtatatga aaccccaacg 420 catgaaaaac gttcagtacg gattaatact tcgggtctat cgggtgctgc gtcctagtag 480 ctttaagtga tacattaatc catacatatc gcttctcagt acacttgacc ggttggcgta 540 atatcgagta ggcgtgtttc aaagtcgtct ggatttatca caccccacct gtcgaatctt 600 taaactttta aacggtttca ttgtgtttta taataaatat tttataattt tgctgcttag 660 ataaggtaag tgattttact tttagttatg gtgatttgga ttttgtctag ttgcacactg 720 ttttatctct attttagtaa ttaatataat aatatagttt agcttgcctc gtccccgccg 780 ggtcacccgg ccagcgacat ggaggcccag aataccctcc ttgacagtct tgacgtgcgc 840 agctcagggg catgatgtga ctgtcgcccg tacatttagc ccatacatcc ccatgtataa 900 tcatttgcat ccatacattt tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg 960 ctgcagacca gcgagcaggg aaacgctccc ctcacagacg cgttgaattg tccccacgcc 1020 gcgcccctgt agagaaatat aaaaggttag gatttgccac tgaggttctt ctttcatata 1080 cttcctttta aaatcttgct aggatacagt tctcacatca catccgaaca taaacaacaa 1140 tgtctgttat taatttcaca ggtagttctg gtccattggt gaaagtttgc ggcttgcaga 1200 gcacagaggc cgcagaatgt gctctagatt ccgatgctga cttgctgggt attatatgtg 1260 tgcccaatag aaagagaaca attgacccgg ttattgcaag gaaaatttca agtcttgtaa 1320 aagcatataa aaatagttca ggcactccga aatacttggt tggcgtgttt cgtaatcaac 1380 ctaaggagga tgttttggct ctggtcaatg attacggcat tgatatcgtc caactgcatg 1440 gagatgagtc gtggcaagaa taccaagagt tcctcggttt gccagttatt aaaagactcg 1500 tatttccaaa agactgcaac atactactca gtgcagcttc acagaaacct cattcgttta 1560 ttcccttgtt tgattcagaa gccggtggga caggtgaact tttggattgg aactcgattt 1620 ctgactgggt tggaaggcaa gagagccccg aaagcttaca ttttatgtta gctggtggac 1680 tgacgccaga aaatgttggt gatgcgctta gattaaatgg cgttattggt gttgatgtaa 1740 gcggaggtgt ggagacaaat ggtgtaaaag actctaacaa aatagcaaat ttcgtcaaaa 1800 atgctaagaa atagtcagta ctgacaataa aaagattctt gttttcaaga acttgtcatt 1860 tgtatagttt ttttatattg tagttgttct attttaatca aatgttagcg tgatttatat 1920 tttttttcgc ctcgacatca tctgcccaga tgcgaagtta agtgcgcaga aagtaatatc 1980 atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg tcgattcgat actaacgccg 2040 ccatccagtg tcgaaacgct atgatccaat atcaaaggat atgtggtaac atattgtaaa 2100 aattgtagtg acttgagttc cacagcatat gaataaaatg gtattattat ttaatattat 2160 tattaattaa tttactttac ttatgctggt tgcgcgaaat ttatctttca tttttcatac 2220 aaacccaatg taggacaata aacatttttt tttactataa attaaattaa tcgttatttg 2280 acatcatatc aacaacaagt cccaccagaa atctaagaaa taagtcccag aaataacaaa 2340 taaattcaaa taaaccgttg tttgagttgg ggtatatagc accccacctg tcacaaattg 2400 tcacaaaaat tcacatgtcg gatgccgggt taagccgcta aaggcattat ccgccaagta 2460 caatttttta ctcttcgaag atagaaaatt tgctgacatt ggtaatacag tcaaattgca 2520 gtactctgcg ggtgtataca gaatagcaga atgggcagac attacgaatg cacacggtgt 2580 ggtgggccca ggtattgtta gcggtttgaa gcaggcggca gaagaagtaa caaaggaacc 2640 tagaggcctt ttgatgttag cagaattgtc atgcaagggc tccctatcta ctggagaata 2700 tactaagggt actgttgaca ttgcgaaaag cgacaaagat tttgttatcg gctttattgc 2760 tcaaagagac atgggtggaa gagatgaagg ttacgattgg ttgattatga cacccggtgt 2820 gggtttagat gacaagggag atgcattggg tcaacagtat agaaccgtgg atgatgttgt 2880 ctctacagga tctgacatta ttattgttgg aagaggacta tttgcaaagg gaagggatgc 2940 taaggtagag ggtgaacgtt acagaaaagc aggctgggaa gcatatttga gaagatgcgg 3000 ccagcaaaac taaaaaactg tattataagt aaatgcatgt atactaaact cacaaattag 3060 agcttcaatt taattatatc agttattacc c 3091 <210> 212 <211> 3168 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 212 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacctttaaa aggtaacgtg ggggtggaaa tacccccact 420 tctaaaaaaa gaggtatatt ttttgtcagg agttggcagc agtcgtgtag ttccaggtac 480 cttcctgtga ccttgaagac agtctgtatt cagtagagtc tcagtgctga cacatcctgt 540 ttattcaaca taacctccaa aagtgcttgg ggagtctctg tacccccacg ttacccgttg 600 tgtcagcaca tttcaccgca tccattcttc tatttctttt ataaaagtaa gtatattata 660 gttttttctg acttgaataa ctagaattgt agttgttata acctaaccta taaactcaca 720 ttaaatttgg ccttcgtaaa cataaactaa cctggatgtg tgttacatag caatttcatc 780 atgtacgact tgcctttaca gttattgtat tattttgtca cattctaaac tcgtttgtgc 840 tttgcagagt ttagcttgcc tcgtccccgc cgggtcaccc ggccagcgac atggaggccc 900 agaataccct ccttgacagt cttgacgtgc gcagctcagg ggcatgatgt gactgtcgcc 960 cgtacattta gcccatacat ccccatgtat aatcatttgc atccatacat tttgatggcc 1020 gcacggcgcg aagcaaaaat tacggctcct cgctgcagac cagcgagcag ggaaacgctc 1080 ccctcacaga cgcgttgaat tgtccccacg ccgcgcccct gtagagaaat ataaaaggtt 1140 aggatttgcc actgaggttc ttctttcata tacttccttt taaaatcttg ctaggataca 1200 gttctcacat cacatccgaa cataaacaac aatgtctgtt attaatttca caggtagttc 1260 tggtccattg gtgaaagttt gcggcttgca gagcacagag gccgcagaat gtgctctaga 1320 ttccgatgct gacttgctgg gtattatatg tgtgcccaat agaaagagaa caattgaccc 1380 ggttattgca aggaaaattt caagtcttgt aaaagcatat aaaaatagtt caggcactcc 1440 gaaatacttg gttggcgtgt ttcgtaatca acctaaggag gatgttttgg ctctggtcaa 1500 tgattacggc attgatatcg tccaactgca tggagatgag tcgtggcaag aataccaaga 1560 gttcctcggt ttgccagtta ttaaaagact cgtatttcca aaagactgca acatactact 1620 cagtgcagct tcacagaaac ctcattcgtt tattcccttg tttgattcag aagccggtgg 1680 gacaggtgaa cttttggatt ggaactcgat ttctgactgg gttggaaggc aagagagccc 1740 cgaaagctta cattttatgt tagctggtgg actgacgcca gaaaatgttg gtgatgcgct 1800 tagattaaat ggcgttattg gtgttgatgt aagcggaggt gtggagacaa atggtgtaaa 1860 agactctaac aaaatagcaa atttcgtcaa aaatgctaag aaatagtcag tactgacaat 1920 aaaaagattc ttgttttcaa gaacttgtca tttgtatagt ttttttatat tgtagttgtt 1980 ctattttaat caaatgttag cgtgatttat attttttttc gcctcgacat catctgccca 2040 gatgcgaagt taagtgcgca gaaagtaata tcatgcgtca atcgtatgtg aatgctggtc 2100 gctatactgc tgtcgattcg atactaacgc cgccatccag tgtcgaaacg ctatgatcca 2160 atatcaaagg actttgggtt gtataaaatg tccactcgtt gtagtttttt tttgtattaa 2220 cattaattaa taaataatat tataacactt ttagatatta ttgtaagttt ttttttccta 2280 taaaatactg tacattttag atatttgtga aaaaaactca tacacaaaac taaaaaaaaa 2340 agaaaaatga tttttttatg attcttgaag tttttcctaa caaaataaac atctaaatta 2400 aatcaaaggt ccataatgtc ttaagtaaat agaaaaaata aatgggggta atcagacacc 2460 ccacgttacc atttatattc tactttccca tgttacccat taaaggttaa gccgctaaag 2520 gcattatccg ccaagtacaa ttttttactc ttcgaagata gaaaatttgc tgacattggt 2580 aatacagtca aattgcagta ctctgcgggt gtatacagaa tagcagaatg ggcagacatt 2640 acgaatgcac acggtgtggt gggcccaggt attgttagcg gtttgaagca ggcggcagaa 2700 gaagtaacaa aggaacctag aggccttttg atgttagcag aattgtcatg caagggctcc 2760 ctatctactg gagaatatac taagggtact gttgacattg cgaaaagcga caaagatttt 2820 gttatcggct ttattgctca aagagacatg ggtggaagag atgaaggtta cgattggttg 2880 attatgacac ccggtgtggg tttagatgac aagggagatg cattgggtca acagtataga 2940 accgtggatg atgttgtctc tacaggatct gacattatta ttgttggaag aggactattt 3000 gcaaagggaa gggatgctaa ggtagagggt gaacgttaca gaaaagcagg ctgggaagca 3060 tatttgagaa gatgcggcca gcaaaactaa aaaactgtat tataagtaaa tgcatgtata 3120 ctaaactcac aaattagagc ttcaatttaa ttatatcagt tattaccc 3168 <210> 213 <211> 2918 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 213 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aacctttcag tacacgcgcg cggaccgtca ctccgcaaaa 420 ttcaaacggt ttaatttgcc cgtggcgcca tctgttgttg agttgacaag tctcttttcc 480 acgtcatccg tagaccgcgt gtgcatttca ctgtttactg tttgacagag agtacgaagt 540 aaatagttgt tgttaatagt aaatagttgt tcttgtttta tattattatt aagtagattt 600 tagttagtgt tagttagtaa tagtgttttg tgtttagtaa agacttaata gtagtgtaag 660 taaataggtt attgtggagt attgtttggt taaaacaggt aaataaaagt acgatttcat 720 taaattgttg tcttgagttt agcttgcctc gtccccgccg ggtcacccgg ccagcgacat 780 ggaggcccag aataccctcc ttgacagtct tgacgtgcgc agctcagggg catgatgtga 840 ctgtcgcccg tacatttagc ccatacatcc ccatgtataa tcatttgcat ccatacattt 900 tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg ctgcagacca gcgagcaggg 960 aaacgctccc ctcacagacg cgttgaattg tccccacgcc gcgcccctgt agagaaatat 1020 aaaaggttag gatttgccac tgaggttctt ctttcatata cttcctttta aaatcttgct 1080 aggatacagt tctcacatca catccgaaca taaacaacaa tgtctgttat taatttcaca 1140 ggtagttctg gtccattggt gaaagtttgc ggcttgcaga gcacagaggc cgcagaatgt 1200 gctctagatt ccgatgctga cttgctgggt attatatgtg tgcccaatag aaagagaaca 1260 attgacccgg ttattgcaag gaaaatttca agtcttgtaa aagcatataa aaatagttca 1320 ggcactccga aatacttggt tggcgtgttt cgtaatcaac ctaaggagga tgttttggct 1380 ctggtcaatg attacggcat tgatatcgtc caactgcatg gagatgagtc gtggcaagaa 1440 taccaagagt tcctcggttt gccagttatt aaaagactcg tatttccaaa agactgcaac 1500 atactactca gtgcagcttc acagaaacct cattcgttta ttcccttgtt tgattcagaa 1560 gccggtggga caggtgaact tttggattgg aactcgattt ctgactgggt tggaaggcaa 1620 gagagccccg aaagcttaca ttttatgtta gctggtggac tgacgccaga aaatgttggt 1680 gatgcgctta gattaaatgg cgttattggt gttgatgtaa gcggaggtgt ggagacaaat 1740 ggtgtaaaag actctaacaa aatagcaaat ttcgtcaaaa atgctaagaa atagtcagta 1800 ctgacaataa aaagattctt gttttcaaga acttgtcatt tgtatagttt ttttatattg 1860 tagttgttct attttaatca aatgttagcg tgatttatat tttttttcgc ctcgacatca 1920 tctgcccaga tgcgaagtta agtgcgcaga aagtaatatc atgcgtcaat cgtatgtgaa 1980 tgctggtcgc tatactgctg tcgattcgat actaacgccg ccatccagtg tcgaaacgct 2040 atgatccaat atcaaaggaa tatattttga taattttttt aaatgtataa atttattcaa 2100 ttaatttcat actcatataa aaaccaaaaa aaaaaattaa attttataat ttttctagcg 2160 ccatctttcg cctggtggca aaaatatatt ttaatgcgga ctctcagtcc ggcgcgtgta 2220 atcttgtgtg tattaaaaac cgcgtgtact ggaaggttaa gccgctaaag gcattatccg 2280 ccaagtacaa ttttttactc ttcgaagata gaaaatttgc tgacattggt aatacagtca 2340 aattgcagta ctctgcgggt gtatacagaa tagcagaatg ggcagacatt acgaatgcac 2400 acggtgtggt gggcccaggt attgttagcg gtttgaagca ggcggcagaa gaagtaacaa 2460 aggaacctag aggccttttg atgttagcag aattgtcatg caagggctcc ctatctactg 2520 gagaatatac taagggtact gttgacattg cgaaaagcga caaagatttt gttatcggct 2580 ttattgctca aagagacatg ggtggaagag atgaaggtta cgattggttg attatgacac 2640 ccggtgtggg tttagatgac aagggagatg cattgggtca acagtataga accgtggatg 2700 atgttgtctc tacaggatct gacattatta ttgttggaag aggactattt gcaaagggaa 2760 gggatgctaa ggtagagggt gaacgttaca gaaaagcagg ctgggaagca tatttgagaa 2820 gatgcggcca gcaaaactaa aaaactgtat tataagtaaa tgcatgtata ctaaactcac 2880 aaattagagc ttcaatttaa ttatatcagt tattaccc 2918 <210> 214 <211> 2866 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 214 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aaccccttaa cctacgattc acgttcgagt gtttcgggcc 420 cgaaacgtaa acaaattcgc gcaaccttcg agccattcgc gcgacttgtg tagtacgctg 480 atcgagccta ttatctcttc gtatcgtgat cagtttcaag ttattcttgg tcactttcgc 540 acatcgaaat ttactctcat aaattctaga gaagcagtcc cacaaggttt agcttgcctc 600 gtccccgccg ggtcacccgg ccagcgacat ggaggcccag aataccctcc ttgacagtct 660 tgacgtgcgc agctcagggg catgatgtga ctgtcgcccg tacatttagc ccatacatcc 720 ccatgtataa tcatttgcat ccatacattt tgatggccgc acggcgcgaa gcaaaaatta 780 cggctcctcg ctgcagacca gcgagcaggg aaacgctccc ctcacagacg cgttgaattg 840 tccccacgcc gcgcccctgt agagaaatat aaaaggttag gatttgccac tgaggttctt 900 ctttcatata cttcctttta aaatcttgct aggatacagt tctcacatca catccgaaca 960 taaacaacaa tgtctgttat taatttcaca ggtagttctg gtccattggt gaaagtttgc 1020 ggcttgcaga gcacagaggc cgcagaatgt gctctagatt ccgatgctga cttgctgggt 1080 attatatgtg tgcccaatag aaagagaaca attgacccgg ttattgcaag gaaaatttca 1140 agtcttgtaa aagcatataa aaatagttca ggcactccga aatacttggt tggcgtgttt 1200 cgtaatcaac ctaaggagga tgttttggct ctggtcaatg attacggcat tgatatcgtc 1260 caactgcatg gagatgagtc gtggcaagaa taccaagagt tcctcggttt gccagttatt 1320 aaaagactcg tatttccaaa agactgcaac atactactca gtgcagcttc acagaaacct 1380 cattcgttta ttcccttgtt tgattcagaa gccggtggga caggtgaact tttggattgg 1440 aactcgattt ctgactgggt tggaaggcaa gagagccccg aaagcttaca ttttatgtta 1500 gctggtggac tgacgccaga aaatgttggt gatgcgctta gattaaatgg cgttattggt 1560 gttgatgtaa gcggaggtgt ggagacaaat ggtgtaaaag actctaacaa aatagcaaat 1620 ttcgtcaaaa atgctaagaa atagtcagta ctgacaataa aaagattctt gttttcaaga 1680 acttgtcatt tgtatagttt ttttatattg tagttgttct attttaatca aatgttagcg 1740 tgatttatat tttttttcgc ctcgacatca tctgcccaga tgcgaagtta agtgcgcaga 1800 aagtaatatc atgcgtcaat cgtatgtgaa tgctggtcgc tatactgctg tcgattcgat 1860 actaacgccg ccatccagtg tcgaaacgct atgatccaat atcaaaggaa ctttttgtag 1920 tacttgcatc taccacaatt attgcatcaa gctgtaatta catatcaaat attccaaaaa 1980 tgtttataat tttaagaggg cgccgccgct aatatttata tttgacccga tcatcgtact 2040 acgggctatg cccgtaatat tcacttctgg cccgatcatc gtacacgggc tatgcccgta 2100 atatttacgt ttggcccgat cagcgtacac gggctatgcc cgtaatattt atttttggcc 2160 cgatcaacgt acacgggctc tgctcgtagt tgtaggttaa ggggttaagc cgctaaaggc 2220 attatccgcc aagtacaatt ttttactctt cgaagataga aaatttgctg acattggtaa 2280 tacagtcaaa ttgcagtact ctgcgggtgt atacagaata gcagaatggg cagacattac 2340 gaatgcacac ggtgtggtgg gcccaggtat tgttagcggt ttgaagcagg cggcagaaga 2400 agtaacaaag gaacctagag gccttttgat gttagcagaa ttgtcatgca agggctccct 2460 atctactgga gaatatacta agggtactgt tgacattgcg aaaagcgaca aagattttgt 2520 tatcggcttt attgctcaaa gagacatggg tggaagagat gaaggttacg attggttgat 2580 tatgacaccc ggtgtgggtt tagatgacaa gggagatgca ttgggtcaac agtatagaac 2640 cgtggatgat gttgtctcta caggatctga cattattatt gttggaagag gactatttgc 2700 aaagggaagg gatgctaagg tagagggtga acgttacaga aaagcaggct gggaagcata 2760 tttgagaaga tgcggccagc aaaactaaaa aactgtatta taagtaaatg catgtatact 2820 aaactcacaa attagagctt caatttaatt atatcagtta ttaccc 2866 <210> 215 <211> 3047 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 215 ttgattcggt aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg 60 tatatatacg catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac 120 tgcacagaac aaaaaccagc aggaaacgaa gataaatcat gtcgaaagct acatataagg 180 aacgtgctgc tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa 240 agcaaacaaa cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag 300 ttgaagcatt aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt 360 tttccatgga gggcacagtt aagagacatt actaaacgaa aggcagtttt tctttacaca 420 cacacacaca cacacacaaa aaacaacaac tttgatgcag acttttgcct ggttcaggaa 480 tcgcgttcga gtaatgaaga ttacaacttc tggaaatcgc aatggggcga ggactcatgg 540 atgtcccatg gaaacagcca ttcagctgga actctaactc ttatattatg tttatggtca 600 atttgaccgg atttcaattt ttgtgttgat caaagcgcct ggttatcctt taaatttaaa 660 aatgtccttt tggtttactt tattttgata acttctgaag agtcattcag caccaggtgt 720 gtgtgaaaga ggaactttct ctccactgtc ctgtacacta tttccatgcc ctttctttga 780 gaaatagacc aaaagtttag cttgcctcgt ccccgccggg tcacccggcc agcgacatgg 840 aggcccagaa taccctcctt gacagtcttg acgtgcgcag ctcaggggca tgatgtgact 900 gtcgcccgta catttagccc atacatcccc atgtataatc atttgcatcc atacattttg 960 atggccgcac ggcgcgaagc aaaaattacg gctcctcgct gcagaccagc gagcagggaa 1020 acgctcccct cacagacgcg ttgaattgtc cccacgccgc gcccctgtag agaaatataa 1080 aaggttagga tttgccactg aggttcttct ttcatatact tccttttaaa atcttgctag 1140 gatacagttc tcacatcaca tccgaacata aacaacaatg tctgttatta atttcacagg 1200 tagttctggt ccattggtga aagtttgcgg cttgcagagc acagaggccg cagaatgtgc 1260 tctagattcc gatgctgact tgctgggtat tatatgtgtg cccaatagaa agagaacaat 1320 tgacccggtt attgcaagga aaatttcaag tcttgtaaaa gcatataaaa atagttcagg 1380 cactccgaaa tacttggttg gcgtgtttcg taatcaacct aaggaggatg ttttggctct 1440 ggtcaatgat tacggcattg atatcgtcca actgcatgga gatgagtcgt ggcaagaata 1500 ccaagagttc ctcggtttgc cagttattaa aagactcgta tttccaaaag actgcaacat 1560 actactcagt gcagcttcac agaaacctca ttcgtttatt cccttgtttg attcagaagc 1620 cggtgggaca ggtgaacttt tggattggaa ctcgatttct gactgggttg gaaggcaaga 1680 gagccccgaa agcttacatt ttatgttagc tggtggactg acgccagaaa atgttggtga 1740 tgcgcttaga ttaaatggcg ttattggtgt tgatgtaagc ggaggtgtgg agacaaatgg 1800 tgtaaaagac tctaacaaaa tagcaaattt cgtcaaaaat gctaagaaat agtcagtact 1860 gacaataaaa agattcttgt tttcaagaac ttgtcatttg tatagttttt ttatattgta 1920 gttgttctat tttaatcaaa tgttagcgtg atttatattt tttttcgcct cgacatcatc 1980 tgcccagatg cgaagttaag tgcgcagaaa gtaatatcat gcgtcaatcg tatgtgaatg 2040 ctggtcgcta tactgctgtc gattcgatac taacgccgcc atccagtgtc gaaacgctat 2100 gatccaatat caaaggaaaa tgtcaaacat tgaaaaaccc caaaaaacag gcaagttaaa 2160 tagttaaaga aaaagtgtta ataattaaaa tcagaagttg cttaatatag tattgaaatt 2220 agtttgttta ttcttctcat gtctcctaaa tgtttgcata atctaagata aagttattat 2280 tgggttaaat taatttcctg tctgttttgt gttgatttac acaatgcagg tcaaaattac 2340 ccgcaacata acaaatgtat tttttttctc aacataatac aaggattaag ccgctaaagg 2400 cattatccgc caagtacaat tttttactct tcgaagatag aaaatttgct gacattggta 2460 atacagtcaa attgcagtac tctgcgggtg tatacagaat agcagaatgg gcagacatta 2520 cgaatgcaca cggtgtggtg ggcccaggta ttgttagcgg tttgaagcag gcggcagaag 2580 aagtaacaaa ggaacctaga ggccttttga tgttagcaga attgtcatgc aagggctccc 2640 tatctactgg agaatatact aagggtactg ttgacattgc gaaaagcgac aaagattttg 2700 ttatcggctt tattgctcaa agagacatgg gtggaagaga tgaaggttac gattggttga 2760 ttatgacacc cggtgtgggt ttagatgaca agggagatgc attgggtcaa cagtatagaa 2820 ccgtggatga tgttgtctct acaggatctg acattattat tgttggaaga ggactatttg 2880 caaagggaag ggatgctaag gtagagggtg aacgttacag aaaagcaggc tgggaagcat 2940 atttgagaag atgcggccag caaaactaaa aaactgtatt ataagtaaat gcatgtatac 3000 taaactcaca aattagagct tcaatttaat tatatcagtt attaccc 3047 <210> 216 <211> 572 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 216 ttaaccgtct gcagctgacg tgtagtccca cagacaccgc gaaatacaaa atcacgtgtt 60 ataccgtcat ttttcaaata tgagcgtcac tgctgcgagt accttactgt atagtgctcg 120 cgcgtcggtc agtgtgcggc ggggggtcgc agcgagcgca cgtgtgcgta gcggagggaa 180 ggtgtccacg agactaccac gtcagcgtta aggtaagtgt ccacgagatt accacttcag 240 tgaaatggtt atatcttcat agtgtctcct aaacaaccac gtcagtcatt gagtttcaat 300 gatttattat tttatgttat tttccaattt tcataaacta tttatactac tattttatta 360 ctacttatac tacttacaat taggacagat ttctactttt gtttgtaatc aattaacttg 420 aatacaaagc cgtttattta acatacaaac aacataacaa tacataataa tgttatctct 480 gagtaacaca ggttacagga aacaatatct atacagcacc cgcgtgtgct taagtcgtgc 540 tagaaaacta acagtattta acttgttttt ag 572 <210> 217 <211> 388 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 217 ttttgaaact ctctagtttt taagttgacc aacgaatgta tctcaatttt cctagactga 60 ttaatgttat tgtgaacttt taaaatgtat aatgtgaaat ttgaaaaatt tgattttgtt 120 atttttttat gtcataaatg tttaagaaga aatttataga ctgatttgtg ttaagtaaat 180 aaaccttgtt taattttgaa aatagatatt gttttttttt ttatttcaat taaatataaa 240 atataaaaag gcaagaaatc taacaaacat gaataaatta gctgcatatt ttaattctaa 300 aaaaatattt gctgttgaaa tggtgtctgg tatactacca cctcagttga attgtaacaa 360 tttaaccacg tcagttgcag agggttaa 388 <210> 218 <211> 378 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 218 ttaaccctta attggtcgcg tggggtgtca tacaccccag agcgggttcc caggcgcaca 60 actttttaaa atttgaattt agcgcgctgc tcttctaggt agcttcgtaa acacgtaaaa 120 cgtacatgat tcagttgcga gcggcgctcg gttgtggacg gttgagctca gagagtgtgt 180 ttggggtgca cgacacccca ggtgactgtt tgtgtggtct aaattccgag taagtaaata 240 gttgttaatt ttattatttc cgttttaaaa cattgtattt tgcaagtgat gaatgttaaa 300 agtgttcaat tataataatt tgacattttt gaggttatgt tgtgatattt ttgtttttgg 360 ttttcagtaa aatcaaaa 378 <210> 219 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 219 aactaggttt tgtaaaaaat attttttata ttaaaaaaat aagttgatta tattaaaaat 60 atgtttaaaa gttaattaat atgtaagtta aaatgttcga attaatacaa gtgtgatttt 120 gcatgtattt agtattttat tttatttcct aattctgggg tgctaagcac cccacgcgac 180 cgcttatgca actttgtagg cgcgcccaat taagggttaa 220 <210> 220 <211> 455 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 220 ttaacacgtt cactgccggt gtcaacacgt agttgacaca cgtacattcg ccggtggcca 60 ctgtcaatac gttgttgaca ccaaaactat ccatttttaa tatattgtca cggggtcggc 120 ttttatcgca tgttatttat ttatttatta atagattcga tagcccgtgt aaaattgaat 180 ggtatagttg gattcatttt tcgaattatt tatagaatat ttttcctaat tattattttc 240 gttgatatta tttaatatct taatatataa tacacatata ccaaattatt attgttgaaa 300 tattacacag ttttatcttt tatgtttgac agtcattctt caacgtgcgt acattgtcgt 360 agtcagtcgt agtcactaga attgatatta ttttgtgtgt gtttttttaa gtacatttaa 420 aattgttcat tttaatccta catagtgata gtata 455 <210> 221 <211> 439 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 221 attaaaaatt atgtttattg ttttatttat atttatactt atttgtaagt taaaaactac 60 agtttaattc aataagtagt atttttttat tttatttcat tttattaaat attaaaaata 120 aatctataca aaaaaaaagt tgaattttca ttttacattt ttgtgtaacc gctgtgttgt 180 agtacaaatt gaaaaaaacc aaagtactta taaactcaat agtatcgtaa tattattgaa 240 aaacataatt gtaagtgtga tgtatgataa tttatcaagt atttatttag atataattgt 300 ggattcttat ttattattag catgaatcgg gcgcgcaacg ccggtgtcaa cacgtagttg 360 acagtatcag ccgagactgg tttttggtta cggctacgcg cgcgctaatg cataattcgg 420 tcggcagtga acgtgttaa 439 <210> 222 <211> 286 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 222 ttaacactcc accgcacgcg cgtctactat tgtagactgc agaatttagt tacgcaatat 60 ttacaacatt catgtaagag aagttgcctg ttttcgtgta ttcctcaaaa atgacaccct 120 taacgtattt agttggtttt caaacgcggt tgctagtgta tcgtcgagtt tttttgttat 180 ttctacgatt gtagagcacg cgtgttctcc cgtaactaat tctgttaccg cgtaagtatg 240 caatttaagc gttatttatg ggtttttcgt tatgttacat ttttag 286 <210> 223 <211> 204 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 223 cttgaagata tattttattt tactccatac tataccttat tttcttttga tttctataaa 60 taaagttgtt ataagtatat ctaatacttt ttattatcag aaatggaaaa taaataaaga 120 ttctaataag acgcgaatgt tctactattg tagtacatgc gtgttttgtt gtatgaaaaa 180 ggggcgcgtg cggtggagtg ttaa 204 <210> 224 <211> 365 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 224 ttaaccctag aatgcacgac tggggtcgat ttcgacccca ggcaaacttt gaactatata 60 cgctcctgtt cgactaactc tctaaaagta cgggctacgt cgggcgcagc gttagttgtt 120 cgctggcagt gacgcagcac cgtcgcaaag cgtgcgtggg gtcgatattg accccagttg 180 tgagtttccg tttgtgtttt gtcacggtaa gctaatttta tattttttgc tagaatcaat 240 atatttcatg tattattacg taatctgagc ataaatagtc ataaatatta tttaagacaa 300 aatatctcac gacttagtcg gtaaaaatcc cgttgcctac agataagatt gacattttgc 360 agaaa 365 <210> 225 <211> 529 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 225 tgcgactaaa taagtatttt tcattttttt tcatattttt tactattttg tatcaaatta 60 aattaaaata atacttaaaa tacaattttt tatggttttt tcatcgattt tttccatatt 120 tcaactttgc gaatttcttc atttttataa tcttaaataa atatactttt tgaacagaac 180 ataacgatga caattttttt ccaattgtct aatgtgtcct cttcaaagtt tgaattttga 240 aaattggttg attacaaaaa aagatacaaa tttttgtttt aaaaaagagg tttttgctga 300 ttttctgcat ttttcggtct tcaaatggat ttttcactaa ctaaacttga gtaaaattaa 360 atttatcgta tactattctc ttttttatta aaaaacgaag aaatttatgt actattaagg 420 ccctttatct ctgtaggacc ggttttacga tcaaaaaagc gttgagtcga tattgacccc 480 agttatgagt taaaaggtaa aaaaaatgac ttgtgcgttc tagggttaa 529 <210> 226 <211> 354 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 226 ttaaccctac agtggtcgcg cggatgacac ttgtcatcca ccacttttaa tttgctgata 60 gagttggtat aggtttaggt ggggaactgt ggttcccaat agctgcttat tatgtatacg 120 catgtggtat gaacgagtag ttttgaattg atttttagta ataaggctcc tagtgtgagt 180 taaagttacc cggaggacag gtgtcatcca cgcgaccatt gacgttagtg ttggtttcat 240 agacactgtg tatattttcc accatttctc atcgctgaag gtaccaatgc agtttatatt 300 ttacattagt tcaacacagc attttaggat ccatattgga ggaaattttc agct 354 <210> 227 <211> 214 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 227 cttgtaaaat aactatcatg tatgtaataa aaatattttt tgagttctgt tggtaattaa 60 tactttctct ataccatcag taataaattc tgattacctt gtaacacaaa aagatattaa 120 atccgtaaag tggccctaaa caaactgtgg atgaccactg tcatccgcgc gattatgccc 180 gtcctaaaca ttgacgcgac cgctgcaggg ttaa 214 <210> 228 <211> 253 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 228 ttaacccgcg agaactcgca ccgggtataa catgcccgat ccattttcat tcaaagtttt 60 tcttactttc ttctattgga acagagccag gatttcgtgt agctgtattc aaggtcacat 120 tctttcacta ggggaaaagc tggttttgtt ctataaatag attttcagga acaggtgtcg 180 ggggtatgtc atacccgtgc tagtcctggc gtcagtcgga tcattccttc tttttctctc 240 agtttagtga att 253 <210> 229 <211> 185 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 229 acatgtgagt atgtattttt aaactcaata aaattcttta atgtattatt ttgtaatgtt 60 taattatgta aggcttgctt ataaacagta ttatttcata tttaggtagc agaaatgaac 120 tagggtatga gatacccagc gcgagttctc gcgttggaaa acggttgcgt gttctcccgg 180 gttaa 185 <210> 230 <211> 411 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 230 ttaaccctag ataactaaac attcgtccgc tcgacgacgc gctatgccgc gaaattgaag 60 tttacctatt attccgcgtc ccccgccccc gccgcttttt ctagcttcct gatttgcaaa 120 atagtgcatc gcgtgacacg ctcgaggtca cacgacaatt aggtcgaaag ttacaggaat 180 ttcgtcgtcc gctcgacgaa agtttagtaa ttacgtaagt ttggcaaagg taagtgaatg 240 aagtattttt ttataattat tttttaattc tttatagtga taacgtaagg tttatttaaa 300 tttattactt ttatagttat ttagccaatt gttataaatt ccttgttatt gctgaaaaat 360 ttgcctgttt tagtcaaaat ttattaactt ttcgatcgtt ttttaggcct a 411 <210> 231 <211> 184 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 231 tcatctttca ctaagtaatt ttgttcctat ttagtagata agtaacacat aattattgtg 60 atattcaaaa cttaagaggt ttaataaata ataataaaaa aaaaatggtt tttatttcgt 120 agtctgctcg acgaatgttt agttattacg taaccgtgaa tatagtttag tagtctaggg 180 ttaa 184 <210> 232 <211> 331 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 232 ttaaccctag aagcccaatc tacgtcattc tgacgtgtat gtcgccgaaa atactctgtc 60 tctttctcct gcacgatcgg attgccgcga acgctcgatt caacccagtt ggcgccgaga 120 tctattggag gactgcggcg ttgattcggt aagtcccgcc attttgtcat agtaacagta 180 ttgcacgtca gcttgacgta tatttgggct ttgtgttatt tttgtaaatt ttcaacgtta 240 gtttattatt gcatcttttt gttacattac tggtttattt gcatgtatta ctcaaatatt 300 atttttattt tagcgtagaa aatacagcct a 331 <210> 233 <211> 375 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 233 tcatcagact gttttttttg tatttgcatt atatattata ttctaaagtt gatttaattc 60 taagaaaaac attaaaataa gtttcttttt gtaaaattta attaattata agaaaaagtt 120 taagttgatc tcatttttta taaaaatttg caatgtttcc aaagttatta ttgtaaaaga 180 ataaataaaa gtaaactgag ttttaattga tgttttatta tatcattata ctatatatta 240 cttaaataaa acaataactg aatgtatttc taaaaggaat cactagaaaa tatagtgatc 300 aaaaatttac acgtcatttt tgcgtatgat tgggctttat aggttctaaa aatatgattg 360 ggcctctagg gttaa 375 <210> 234 <211> 433 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 234 ttaaccctca aatggttttt ggggtccatt ggaccccaga ggcaaattag aaaccatttg 60 cagggggcat gtgtacaata gcaggccaat atttttggag aattactttt tctatggctt 120 ttctatgccc atagaaactc aattgtgtga caggtttaat atcttgaata attggactta 180 ttcggttgaa tgaattctgg ggtccaaggg accccagaca agcaagccca taatattgtt 240 gtgatatcta tggttgatgc ccagtcatat aaatatgatt ccacaaagca actctcacga 300 ctattttatg tctgctgcct accgcaactg acttgtgtgt tctaacggca atcagcttca 360 gttgataagt tcaactatcg cgtacaactc tggcaacttt gtcaatccgc cactgaaagc 420 gctgccgaca ctg 433 <210> 235 <211> 531 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 235 cttgctgtac gagcatcatt tctgctattt caaagttatt acaattcaga acttgctaca 60 aaattgcctt taacacttga gcaagatgag ctgatagcat aactggctat aatacaacat 120 atacatacca tatatacata ttacatactt ataataagta atctcaaaaa tttaatctca 180 aatctcaaaa tctaaatttt ccataactta tcataagcac agagctatgt gcaagttctg 240 attgtacact ttttgcagct tcttttaatt gctcagcatc atgaatttgt acttacatgt 300 aaatatgact atcgcctaat tttcatgtaa ctgtcatctg tgtgcaaaca cctgttctgt 360 gctttgcaaa cacctgtact taataaagtc aaataataat taatattaaa attaatagtc 420 aaataaacta cacaaataat ctgttgtgct cagcatcaga ttctgaatgg ggtccattgg 480 accccagaaa aaagaaacag actatttttt ctttaactgt ttgagggtta a 531 <210> 236 <211> 837 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 236 ttaaccagtt aaccgtgttt gacgactata tccgtcatgg agatttggca gaattttgtg 60 ccatgacgac tttatccgtc atgtgtaaaa ttttgttaca attcgatatt taaattgtag 120 ttctggagaa aattaaattt tattcctaaa ttttaatatg tttaaaatgt tcagaggtca 180 caacgaaatg aaacaagcaa ataaaaatta taaataattt aagttgattc ataacggtct 240 gagagctaac tcgtgaacag tgcagttata tctggatatt tgattatccc gattttcatc 300 ttgatgtacc aaaaccaaaa aaaagtttat tagattctta atttagattc tgtattcttt 360 tttatactag attctctatt tgcggtgata cctggaaaca gctcatgtgc gctatctcac 420 tccttgtttg ttttggatca ggcaattttt gttgctattc agcgcagttc taggacttat 480 cggggatgga gatgaaacgg ttgattttta tcagttgtcc gagaattcgt aaacgggggc 540 cacccggata tattgttagc ctcacatctt gtgcaaactt tagcgcaggc cgcgattaga 600 tatccccact taggtttatt cactcttccg cggtttacta gactctaacc cacgtttgtc 660 atttcaattt ttgaacgtga acgatgcagt gcatttcagt gtgtctgaaa tagtcagtga 720 atcgtgccaa gtcatataaa gtgcaatgta agtgtttcaa gtgtctaatt attatagtta 780 tccagaaaac tttcgtaacc cactattttt ttattcttag cttattttat ccccaaa 837 <210> 237 <211> 240 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 237 aattttgttc aactttttaa agttttccat tcattatgta taaatatatg ttcacattaa 60 gcgactgtac aagtattacg aataaaattg ttcattttct aaaatcaagt cgtcattttg 120 acccaatatt tcaacagtgc cacttactct gtgtttgacg actatacccg tcatcgcttg 180 attatcgcga cacacactgg tgcgcgcttt gcccacaggt cgccacggtt aactggttaa 240 <210> 238 <211> 288 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 238 ttaacccctt aacctacgat ttagattcga agatgttagg ccgaaattgt atacaagttc 60 gcgcagcgtt cgggacgttc gcacgacttg ggtacacgcc gatccgggca attgtaaaca 120 tgacggacat cgcccgtggt agagcggtcg cggtttgtag atagcacaga caagactcgt 180 gatgtatttc tatcatctct tcgtatcgta attagtttcc agtcgttctt gatcgcattc 240 gcacgtcgaa atttacgttc ataaattcta gagaagcaaa cccacaag 288 <210> 239 <211> 164 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 239 ttttgtattt tggagttttg tataaataaa tattttgtaa tacttgcgcc taccacaatt 60 attgcatcag actgtaaatg cgtatcaaat attccacgta atatttacat cgggcccgat 120 caccgtacgc gggctatgcc cgtcattgta ggttaagggg ttaa 164 <210> 240 <211> 280 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 240 ttaaccttta agtatggacg tggagtctca caggctactc aatgtttacg ttttcatagt 60 ttcacctatt tccccccgct ccccgcgatt gagcagctca gtagcttttg ttttagttgc 120 caaactacca acgagggagg aggttgtgtc gtccggtgaa tctcacgtga gttataacca 180 tcgaaaaatt gactggagcc tgttaggcta cacgtccatt gttgtcatat aatatatttt 240 ataagggcga ttatgtttgt ttcagatttt gtagtacaaa 280 <210> 241 <211> 400 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 241 atttgcgtta ttagactgtt gtcaaaattt tttgtattag ttacctgaag taggtttttt 60 gtgtttttgg ttccttatct attatatttt aagaaaaaaa gacaaatttt gttatagtaa 120 taagttgagc tgttttaaat atctaaaaat gtagcctaag taaattaaga cttaaaagtg 180 ccataattat tgatttttca catttctata tttttgttaa taaaagatga ttatataagc 240 atgttatttt attgctaaat accttaactg taatatccaa tcagttttta agcaacctta 300 tatcaaattc tcaaaaaaaa agtgttagca tataggagcc tgtgagactc cacgtccgca 360 gtagtgttaa gaaaaaatta cgtccatact taaaggttaa 400 <210> 242 <211> 258 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 242 ttaacccggc gtgattgacg ctgggtcaca gtgacccagc gcgttttaaa acggccatat 60 tttttttatg agttgatcat ttgttttaac cgtttaagta gctggagtta cgtcccccct 120 ctccttagtc ggccggtaag tttagtgcta cgtcggctgc gcagcgagat acacgtgcgc 180 caagtcaacg cgggtaagtt tgacccagcg tcatcgcggg cgtcgtattt ttgtggcatt 240 ccttttttaa ttaatttt 258 <210> 243 <211> 362 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 243 tttcttacta tttttaatat aaaagtattt ttgatctctt atctataacc taagattgtt 60 agttcctatt attcgtaaga aaagtctatt aaaattgtta aaagtagaac aaactaatga 120 atgttaaatt ttgaaccttg attttgcatg tgttactttg gaaaccaata aaagtatgat 180 tgatttaata taatggcata attttatttt ataacaagcg cagacgaccc tttttaacaa 240 ataactaaaa aaaataagat aacgtctttt atttcgcaaa aaatttactt tataatgagg 300 ggtaattgtg acccagtgtc attgaccacg taattttttt cacgtcaatc acgccgggtt 360 aa 362 <210> 244 <211> 379 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 244 ttaaccctgg aatactatac cggggtactg gattccccgg gccatttagt ttttctgatt 60 ttcaggagat ggcagcactt atctgattgt gcttccaggt attctcctaa ctcttaagca 120 tctattcagt tgcaggtttg aacttgttct aagtggttgt gttttgtggt atcgctgtct 180 tggggcagtc aattccccag tgtagtgttc atgtaagtat aacaaattat agcttttcta 240 tcttctataa ttgagaactg attattgata tttattataa gttgtataat gcttttttat 300 aattaattat taattaataa tgtaaagttg attaattaat cataataatt gcattatttc 360 ttaattacag ctctccaaa 379 <210> 245 <211> 182 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 245 aggttattgt agtggaacag aatcctgtta atgtagtagt aagtattgta tttacatatt 60 atcattaaag aaagtgtgag tttttacgat attattttta attattattt tccttgtggg 120 gcatctagtt ccccagtgta gtactagtgt cgccagcaac aactgtagta ttccagggtt 180 aa 182 <210> 246 <211> 378 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 246 ttaacccggc atccgacaca tggggtatat gaaaccccaa cgcatgaaaa acgttcagta 60 cggattaata cttcgggtct atcgggtgct gcgtcctagt agctttaagt gatacattaa 120 tccatacata tcgcttctca gtacacttga ccggttggcg taatatcgag taggcgtgtt 180 tcaaagtcgt ctggatttat cacaccccac ctgtcgaatc tttaaacttt taaacggttt 240 cattgtgttt tataataaat attttataat tttgctgctt agataaggta agtgatttta 300 cttttagtta tggtgatttg gattttgtct agttgcacac tgttttatct ctattttagt 360 aattaatata ataatata 378 <210> 247 <211> 354 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 247 tatgtggtaa catattgtaa aaattgtagt gacttgagtt ccacagcata tgaataaaat 60 ggtattatta tttaatatta ttattaatta atttacttta cttatgctgg ttgcgcgaaa 120 tttatctttc atttttcata caaacccaat gtaggacaat aaacattttt ttttactata 180 aattaaatta atcgttattt gacatcatat caacaacaag tcccaccaga aatctaagaa 240 ataagtccca gaaataacaa ataaattcaa ataaaccgtt gtttgagttg gggtatatag 300 caccccacct gtcacaaatt gtcacaaaaa ttcacatgtc ggatgccggg ttaa 354 <210> 248 <211> 470 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 248 ttaaccttta aaaggtaacg tgggggtgga aataccccca cttctaaaaa aagaggtata 60 ttttttgtca ggagttggca gcagtcgtgt agttccaggt accttcctgt gaccttgaag 120 acagtctgta ttcagtagag tctcagtgct gacacatcct gtttattcaa cataacctcc 180 aaaagtgctt ggggagtctc tgtaccccca cgttacccgt tgtgtcagca catttcaccg 240 catccattct tctatttctt ttataaaagt aagtatatta tagttttttc tgacttgaat 300 aactagaatt gtagttgtta taacctaacc tataaactca cattaaattt ggccttcgta 360 aacataaact aacctggatg tgtgttacat agcaatttca tcatgtacga cttgccttta 420 cagttattgt attattttgt cacattctaa actcgtttgt gctttgcaga 470 <210> 249 <211> 339 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 249 ctttgggttg tataaaatgt ccactcgttg tagttttttt ttgtattaac attaattaat 60 aaataatatt ataacacttt tagatattat tgtaagtttt tttttcctat aaaatactgt 120 acattttaga tatttgtgaa aaaaactcat acacaaaact aaaaaaaaaa gaaaaatgat 180 ttttttatga ttcttgaagt ttttcctaac aaaataaaca tctaaattaa atcaaaggtc 240 cataatgtct taagtaaata gaaaaaataa atgggggtaa tcagacaccc cacgttacca 300 tttatattct actttcccat gttacccatt aaaggttaa 339 <210> 250 <211> 358 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 250 ttaacctttc agtacacgcg cgcggaccgt cactccgcaa aattcaaacg gtttaatttg 60 cccgtggcgc catctgttgt tgagttgaca agtctctttt ccacgtcatc cgtagaccgc 120 gtgtgcattt cactgtttac tgtttgacag agagtacgaa gtaaatagtt gttgttaata 180 gtaaatagtt gttcttgttt tatattatta ttaagtagat tttagttagt gttagttagt 240 aatagtgttt tgtgtttagt aaagacttaa tagtagtgta agtaaatagg ttattgtgga 300 gtattgtttg gttaaaacag gtaaataaaa gtacgatttc attaaattgt tgtcttga 358 <210> 251 <211> 201 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 251 atatattttg ataatttttt taaatgtata aatttattca attaatttca tactcatata 60 aaaaccaaaa aaaaaaatta aattttataa tttttctagc gccatctttc gcctggtggc 120 aaaaatatat tttaatgcgg actctcagtc cggcgcgtgt aatcttgtgt gtattaaaaa 180 ccgcgtgtac tggaaggtta a 201 <210> 252 <211> 208 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 252 ttaacccctt aacctacgat tcacgttcga gtgtttcggg cccgaaacgt aaacaaattc 60 gcgcaacctt cgagccattc gcgcgacttg tgtagtacgc tgatcgagcc tattatctct 120 tcgtatcgtg atcagtttca agttattctt ggtcactttc gcacatcgaa atttactctc 180 ataaattcta gagaagcagt cccacaag 208 <210> 253 <211> 299 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 253 actttttgta gtacttgcat ctaccacaat tattgcatca agctgtaatt acatatcaaa 60 tattccaaaa atgtttataa ttttaagagg gcgccgccgc taatatttat atttgacccg 120 atcatcgtac tacgggctat gcccgtaata ttcacttctg gcccgatcat cgtacacggg 180 ctatgcccgt aatatttacg tttggcccga tcagcgtaca cgggctatgc ccgtaatatt 240 tatttttggc ccgatcaacg tacacgggct ctgctcgtag ttgtaggtta aggggttaa 299 <210> 254 <211> 416 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 254 ttaagagaca ttactaaacg aaaggcagtt tttctttaca cacacacaca cacacacaca 60 aaaaacaaca actttgatgc agacttttgc ctggttcagg aatcgcgttc gagtaatgaa 120 gattacaact tctggaaatc gcaatggggc gaggactcat ggatgtccca tggaaacagc 180 cattcagctg gaactctaac tcttatatta tgtttatggt caatttgacc ggatttcaat 240 ttttgtgttg atcaaagcgc ctggttatcc tttaaattta aaaatgtcct tttggtttac 300 tttattttga taacttctga agagtcattc agcaccaggt gtgtgtgaaa gaggaacttt 360 ctctccactg tcctgtacac tatttccatg ccctttcttt gagaaataga ccaaaa 416 <210> 255 <211> 272 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 255 aaatgtcaaa cattgaaaaa ccccaaaaaa caggcaagtt aaatagttaa agaaaaagtg 60 ttaataatta aaatcagaag ttgcttaata tagtattgaa attagtttgt ttattcttct 120 catgtctcct aaatgtttgc ataatctaag ataaagttat tattgggtta aattaatttc 180 ctgtctgttt tgtgttgatt tacacaatgc aggtcaaaat tacccgcaac ataacaaatg 240 tatttttttt ctcaacataa tacaaggatt aa 272 <210> 256 <211> 15225 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 256 atgggagtga aggtcctgtt cgcactgatt tgcatcgccg tggcggaagc cgaagtgcaa 60 cttgtggaat cggggggagg tttggtgcaa cctggaggat cattgagact gtcatgtgca 120 gcctcgggat tcaatatcaa ggacacttac atccactggg tgcggcaggc tccgggaaag 180 ggcctggaat gggtggcccg gatctacccc accaacggct acactcgcta cgctgactcc 240 gtgaagggac gcttcactat tagcgcggat acctccaaga acaccgccta cttgcaaatg 300 aactccctcc gggccgagga caccgccgtc tactactgct cgcgatgggg gggagatggc 360 ttctacgcga tggactactg gggccagggg acgctcgtca ctgtgtcgag cgcatccact 420 aaggggccta gcgtctttcc gctggccccg tcctccaagt ccacttcggg tggaaccgcg 480 gcactggggt gcctcgtgaa ggactacttc cccgagccgg tcaccgtgtc ctggaactcg 540 ggagccctga cctccggagt gcatactttc cctgcggtgc tgcagtcctc cgggctctac 600 tcgctgtcaa gcgtggtcac cgtcccgagc tcatccctgg gtactcagac ctacatttgc 660 aacgtgaacc acaaaccttc caacaccaag gtcgacaaga aagtggagcc taagagctgc 720 gacaagaccc acacctgtcc cccgtgtccc gcccctgagc tgctgggcgg ccccagcgtg 780 ttcctcttcc cgcctaagcc gaaggacact ctgatgatct cgagaacccc tgaagtgacc 840 tgtgtggtgg tggatgtgtc ccacgaggat ccggaagtga agttcaattg gtacgtggac 900 ggagtggaag tccataacgc caagaccaag ccccgcgagg aacagtacaa ctcaacttac 960 cgggtggtgt cagtgctgac cgtgctgcac caagattggc tgaacgggaa ggagtacaag 1020 tgcaaagtct ccaacaaggc gctgccggcc cccattgaaa agaccatcag caaggctaag 1080 ggccagcccc gggaaccaca ggtctacacc ttgccccctt cccgggagga aatgaccaag 1140 aaccaagtgt cgctgacgtg cctggtcaag ggcttttatc catctgacat cgccgtggag 1200 tgggaaagca acggccagcc ggaaaacaac tacaagacta ccccgcctgt gctggactcc 1260 gacggctcgt tcttcctgta ttccaagctc accgtggata agtccagatg gcagcagggc 1320 aatgtgttca gctgcagcgt gatgcatgag gccctgcaca accactacac tcagaaatca 1380 ctgtcccttt cccccggaaa gtaatgaggt atcgggggag gctaactgaa acacggaagg 1440 agacaatacc ggaaggaacc cgcgctatga cggcaataaa aagacagaat aaaacgcacg 1500 ggtgttgggt cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat 1560 accccaccga gtccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac 1620 cccccaagtt cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc 1680 atagaaatcg ataatatatg gtagggttca tagccagagt aacctttttt tttaattttt 1740 attttatttt atttttgagt cgggcgcgcc aaaatgaagt gaagttccta tactttctag 1800 agcgagctca cggggacagc ccccccccaa agcccccagg gatgtaatta cgtccctccc 1860 ccgctagggg gcagcagcga gccgcccggg gctccgctcc ggtccggcgc tccccccgca 1920 tccccgagcc ggcagcgtgc ggggacagcc cgggcacggg gaaggtggca cgggatcgct 1980 ttcctctgaa cgcttctcgc tgctctttga gcctgcagac acctgggggg atacggggaa 2040 aaagctttag gctgaaagag agatttagaa tgacaggcga gctcacgggg acagcccccc 2100 cccaaagccc ccagggatgt aattacgtcc ctcccccgct agggggcagc agcgagccgc 2160 ccggggctcc gctccggtcc ggcgctcccc ccgcatcccc gagccggcag cgtgcgggga 2220 cagcccgggc acggggaagg tggcacggga tcgctttcct ctgaacgctt ctcgctgctc 2280 tttgagcctg cagacacctg gggggatacg gggaaaaagc ttgaaacttg atctgtcgcc 2340 gcaattcaag cttcgtgagg ctccggtgcc cgtcagtgac ctgctatact ctggagacga 2400 gcggggctga cgtcgggagg tggcctccgt gggaagggac acccggatct tgacacagcc 2460 ttggcagcgg agtaaggaag agtagggata gattctggcc gccctcttgg ccagcttctc 2520 gccgccccac cctccgctag ggccaagagt aattcataca aaaggaggga tcgccttcgc 2580 aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct gtagccgccc 2640 cacgacagcg cgaggagcat gcgctcaggg ctgagcgcgg ggagagcaga gcacacaagc 2700 tcatagaccc tggtcgtggg ggggaggacc ggggagctgg cgcggggcaa actgggaaag 2760 cggtgtcgtg tgctggctcc gccctcttcc cgagggtggg ggagaacggt atataagtgc 2820 ggcagtcgcc ttggacgttc tttttcgcaa cgggtttgcc gtcagaacgc aggtgagggg 2880 cgggtgtggc ttccgcgggc cgccgagctg gaggtcctgc tccgagcggg ccgggccccg 2940 ctgtcgtcgg cggggattag ctgcgagcat tcccgcttcg agttgcgggc ggcgcgggag 3000 gcagagtgcg aggcctagcg gcaaccccgt agcctcgcct cgtgtccggc ttgaggccta 3060 gcgtggtgtc cgcgccgccg ccgcgtgcta ctccggccgc actctggtct tttttttttt 3120 gttgttgttg ccctgctgcc ttcgattgcc gttcagcaat aggggctaac aaagggaggg 3180 tgcggggctt gctcgcccgg agcccggaga ggtcatggtt ggggaggaat ggagggacag 3240 gagtggcggc tggggcccgc ccgccttcgg agcacatgtc cgacgccacc tggatggggc 3300 gaggcctggg gtttttcccg aagcaaccag gctggggtta gcgtgccgag gccatgtggc 3360 cccagcaccc ggcacgatct ggcttggcgg cgccgcgttg ccctgcctcc ctaactaggg 3420 tgaggccatc ccgtccggca ccagttgcgt gcgtggaaag atggccgctc ccgggccctg 3480 ttgcaaggag ctcaaaatgg aggacgcggc agcccggtgg agcgggcggg tgagtcaccc 3540 acacaaagga agagggcctg gtccctcacc ggctgctgct tcctgtgacc ccgtggtcct 3600 atcggccgca atagtcacct cgggcttttg agcacggcta gtcgcggcgg ggggagggga 3660 tgtaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg ccagcctggc 3720 gctggaagtc atttttggaa tttgtcccct tgagttttga gcggagctaa ttctcgggct 3780 tcttagcggt tcaaaggtat cttttaaacc cttttttagg tgttgtgaaa accaccgcta 3840 attcaaagca agccgccacc atggacatga gggtccccgc tcagctcctg gggctcctgc 3900 tgctctggct cccaggtgcc aaatgtgata ttcagatgac ccaatccccc tcctcattga 3960 gcgcgtccgt cggagacaga gtgaccatta cttgtcgcgc ctcccaagac gtgaacaccg 4020 ctgtggcttg gtaccagcag aagccgggaa aggcccctaa gctgctgatc tactctgcct 4080 ccttcctgta ctcgggcgtg ccgagccggt tcagcgggag ccggtcggga accgatttca 4140 ctctgaccat ctcgtcactg caacccgagg actttgccac ctactactgc cagcagcact 4200 acaccactcc accgaccttc ggacaaggca ccaaggtcga aatcaagcgc accgtggccg 4260 cccctagcgt gtttatcttc cctccctcgg atgagcagct taagtcaggc accgcatccg 4320 tggtctgcct gctcaacaac ttctacccga gggaagccaa agtgcagtgg aaagtggaca 4380 acgcgctcca gtcgggaaac tcccaggagt ccgtgaccga acaggactcc aaggacagca 4440 cttattccct gtcctccact ctgacgctgt caaaggccga ctacgagaag cacaaggtct 4500 acgcctgcga agtgacccat caggggcttt cctcgcccgt gactaagagc ttcaatcggg 4560 gcgaatgcta ataaaagctt aattaagatc cttttccctc tgaccagaat tatgggaaca 4620 tcatgaagcc ccttgagcat ctagcttctg gctaataaag gaaatttatt ttcattgcaa 4680 tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt 4740 taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat atgctggctg 4800 ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc cctgctgtcc 4860 attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata ttttgttttg 4920 tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta gccagatttt 4980 tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg agatcagaaa 5040 attttgtgtc gcccttcgct gaacaccagg tgggccgcct actgcgcacg cgcgggtttg 5100 cgggcagccg cctgggctgt gggagcagcc cgggcagagc tctcctgcct ctccaccagc 5160 ccaccccgcc gcctgaccgc cccctcccca ccccccaccc cccacccccg gaaaacgcgt 5220 cgtcccctgg gctgggtggt gacccccgtc ccgcgaaaca ccgggccccg cgcagcgtcc 5280 gggcctgaca ccgctccggc ggctcgcctc ctatgcgccc ccgcgccacc gtcgcccgcc 5340 cgcccgggcc cctgcagccg cccaggtgcc agcacggagc gcctggcggc ggaacgcaga 5400 ccccaggccc ggcgcacacc ggggacgctg agcgttccag gcgggaggga aggcgggcag 5460 agatggagag aggaacggga gtcctagagg ggcggaagga cgggcggagg gacgttagga 5520 gggagggagg gaggcaggga ggcagggagg aacggaggga aagacagagc gacgcaggga 5580 ctgggggcgg gcgggaggga gccggggaac ggggggagga aggcagggag gaaaagcggt 5640 cctcggcctc cgggagtagc gggacccccg ccctccggga aaacggtcag cgtccggcgc 5700 gggctgaggg ctgggcccac agccgccgcg ccggccggcg gggcaccacc cattcgcccc 5760 ggttccgtgg cccagggagt gggcggtttc ctccgggaca aaagaccggg actcgggttg 5820 ccgtcgggtg ttcacccgcg cggttcacag accgcacatc cccaggctga gccctgcaac 5880 gcggcgcgag gccgacagcc ccggccacgg aggagccaca cgcaggacga cggaggcgtg 5940 attttggttt ccgcgtggct ttgccctccg caaggcggcc tgttgctcaa gtctctccgg 6000 cccccgaaag gctggccatg ccgactgttt gctcccggag ctctgcgggc acccggaaac 6060 atgcagggaa gggtgcaagc ccggcacggt gccttcgctc tccttgccag gttccaaacc 6120 ggccacactg cagactcccc acgttgccgc acgcgggaat ccatcgtcag gccatcacgc 6180 cggggaggca tctcctctct ggggtgtcgc tctggacttc tacgtggaaa tgaacgagag 6240 ccacacgcct gcgtgtgcca gaccgtcccg gcaacggcga cgcccacagg cattgcctcc 6300 ttcacggaga gagggcctgg cacactcaag actcccacgg aggttcagtt ccacactcca 6360 cctaggagat actgaatatt gaaaatctca gaaaatgtga caagttaaat tacaaaaaaa 6420 aagtgtttgt gaaggaaaaa aatattaaat atagtgttgg aataaaaaaa tagtattgtt 6480 tgtctctttc ctaaatgttg aaatattcta aaataaagtt gatatcagtt taacctgttt 6540 ttttattgtt ttgagtggat ttacacagta tgggtcaaaa tgacccgcaa cataatcaag 6600 gtaatttttt ttcaacataa tacgagggtt aatccgccta aggtgctggt tcttttggtg 6660 cttgtatttt ttttcttccc ataatacaaa gataattatg aatgtgccta atgctaaaaa 6720 gactgttaaa aattaatatt ttatgtaagt ttgttgatta tttctaatat tttaatgaat 6780 actttgtgat ttttgatctc atgtgatttt gccaaaaatt ttgctaagtg ttttttaaaa 6840 acactcaaaa gttaattata aataaaaaaa ttaaacaaaa aacattttat tttatttaaa 6900 atctatccac aaaagcttat tattatacaa taaaacctaa aaaccccaaa tattttaaaa 6960 tatgaacatt tatatacacg ggccgcggag gcccccacgt cagtacttac gtgaaaataa 7020 ttccacctca gtagctaaag gttaagcgag aagattgcga gctgtatctt ttcgattatc 7080 caaagataat agtattttag ttgatttatt agtgccttaa attaatgaaa gtctgacttc 7140 gatctctgca ttatatgtaa gattgttaat tatagaacta agagtttaat ttctgttaat 7200 taaaattaag cgattttgaa taattgttaa ataaagatat tttcacatac atttacatat 7260 tttatttatt atctgtaata ataatacatt ctaaaagaca taaatataaa acaaaatttt 7320 cctagcttgt tcatttgtgt aaaacatgta ttttcaatat cgggtttgac agacccacca 7380 ggcatgccgt gtgattttta tgtaccaggc atgtcaaggg ttaagcggcc gctcagcctt 7440 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 7500 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 7560 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 7620 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 7680 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 7740 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 7800 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 7860 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 7920 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 7980 agtggtgggc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga 8040 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 8100 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 8160 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgacgcg cgcgtaactc 8220 acgttaaggg attttggtca tgagttagaa aaactcatcg agcatcaaat gaaactgcaa 8280 tttattcata tcaggattat caataccata tttttgaaaa agccgtttct gtaatgaagg 8340 agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt ctgcgattcc 8400 gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa ggttatcaag 8460 tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagtt tatgcatttc 8520 tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac tcgcatcaac 8580 caaaccgtta ttcattcgtg attgcgcctg agcgaggcga aatacgcgat cgctgttaaa 8640 aggacaatta caaacaggaa tcgagtgcaa ccggcgcagg aacactgcca gcgcatcaac 8700 aatattttca cctgaatcag gatattcttc taatacctgg aacgctgttt ttccggggat 8760 cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga tggtcggaag 8820 tggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat cattggcaac 8880 gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat acaagcgata 8940 gattgtcgca cctgattgcc cgacattatc gcgagcccat ttatacccat ataaatcagc 9000 atccatgttg gaatttaatc gcggcctcga cgtttcccgt tggatatggc tcatttttta 9060 cttcctcacc ttgtcgtatt atactatgcc gatatactat gccgatgatt aattgtcgac 9120 actgcggggg ctctggcgcg ccgtttaaac ttaaccctca tattatgtta agggtcaatt 9180 tgacccattt cagtttttgg tttgaccaaa gaactggtta tcctttcttt ttcttcacga 9240 aagttggtga cttttcctca tctagggtca tgaacttgtg tgtaaaatct ggatactgtg 9300 aagtgtcgtg gaatgtctgt gaacagtttg tatacaaaga tgatgttgcg ggtcattttg 9360 acccacacac tttgatgtga gcaagtagct gtccagatcc gaaataaaca tgtctctttg 9420 atgcacttta ttttgattgc taaattattt atattttgac tgtctctgaa tagaccttca 9480 gatcagagac tcaggtgtgt gtgggggagg agctttctct cccttgtcct tgtcactgtt 9540 ctcgtgtcat ctctttgaga aacagcaaaa ctgtctaact ggtccgatcc ttaaccttta 9600 actgctgagg tgggggcttt tcgagcctag cgaaagtgaa attgttcccc tcctcccttc 9660 ccccgcgcgc gacaaacccg taacttctag tagcttcgat gttagttgcg cctaggccgt 9720 cagaagcttc gcacgtgttt tcgtgcgcaa ttcggtaagt aaattcaatt tgaaatttgt 9780 cgcgggcttc ttaggcccca cctcagtgtt tacgtaactt ttttgtaaat agtttcgatt 9840 aagttattgt gttttttttt tgcagtagct tgaaaacgtt tgaaaaggct gagttgacgt 9900 atctgtttaa cccttggcat gcctggtagg gtttattaga cccaccactt tgaaaaacct 9960 atgatatttt tttaaattga aggctattgt tgacgtgtgt tatagtagct tcgcgcaata 10020 aaccggcggc cattttgacg agcgaacttc agtctcacgt gagcgtgcgt gcgagtagca 10080 cgtgtgtaaa gtgcgcgcgg gcccgtggga ccctaccagg catacaacgt aacattctgt 10140 cggtaagaat attttcttta ttttttggca tttctttgtt taatgtgtta aattataata 10200 cgaaaaaaat attgttgcag tagaagctag cgcgagctca cggggacagc ccccccccaa 10260 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 10320 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 10380 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 10440 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 10500 tgacagaatc atagaacggc ctgggttgca aaggagcaca gtgctcatcc agatccaacc 10560 ccctgctatg tgcagggtca tcaaccagca gcccaggctg cccagagcca catccagcct 10620 ggccttgaat gcctgcaggg atggggcatc cacagcctcc ttgggcaacc tgttcagtgc 10680 gtcaccaccc tctgggggaa aaactgcctc ctcatatcca acccaaacct cccctgtctc 10740 agtgtaaagc cattccccct tgtcctatca agggggagtt tgctgtgaca ttgttggtct 10800 ggggtgacac atgtttgcca attcagtgca tcacggagag gcagatcttg gggataagga 10860 agtgcaggac agcatggacg tgggacatgc tggtgttgag ggctctggga cactctccaa 10920 gtcacagcgt tcagaacagc cttaaggata agaagatagg atagaaggac aaagagcaag 10980 ttaaaaccca gcatggagag gagcacaaaa aggccacaga cactgctggt ccctgtgtct 11040 gagcctgcat gtttgatggt gtctggatgc aagcagaagg ggtggaagtg cttgcctgga 11100 gagatacagc tgggtcagta ggactgggac aggcagctgg agaattgcca tgtagatgtt 11160 catacaatcg tcaaatcatg aaggctggaa aagccctcca agatccccaa gaccaacccc 11220 aacccaccca ccgtgcccac tggccatgtc cctcagtgcc acatccccac agttcttcat 11280 cacctccagg gacggtgacc cccccacctc cgtgggcagc tgtgccactg cagcaccgct 11340 ctttggagaa ggtaaatctt gctaaatcca gcccgaccct cccctggcac aacgtaaggc 11400 cattatctct catccaactc caggacggag tcagtgagaa tattggtacc ggggtgtggt 11460 gtcttccaga catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt 11520 gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa 11580 gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg 11640 aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg 11700 atctctagtc aaggcactat acatcaaata ttccttatta acccctttac aaattaaaaa 11760 gctaaaggta cacaattttt gagcatagtt attaatagca gacactctat gcctgtgtgg 11820 agtaagaaaa aacagtatgt tatgattata actgttatgc ctacttataa aggttacaga 11880 atatttttcc ataattttct tgtatagcag tgcagctttt tcctttgtgg tgtaaatagc 11940 aaagcaagca agagttctat tactaaacac agcatgactc aaaaaactta gcaattctga 12000 aggaaagtcc ttgggatctt ctacctttct cttctttttt ggaggagtag aatgttgaga 12060 gtcagcagta gcctcatcat cactagatgg catttcttct gagcaaaaca ggttttcctc 12120 attaaaggca ttccaccact gctcccattc atcagttcca taggttggaa tctaaaatac 12180 acaaacaatt agaatcagta gtttaacaca ttatacactt aaaaatttta tatttacctt 12240 agagctttaa atctctgtag gtagtttgtc caattatgtc acaccacaga agtaaggttc 12300 cttcacaaag atctctctgg ggcggggtgg gatgaactag gaaaggctca agatcactca 12360 aagtctaatt attagttttt gtattggaag ggctcgtcgc cagtctcatt gagaaggcat 12420 gtgcggacga tggcttctgt cactgcaaag gggtcacaat tggcagaggg gcggcgatct 12480 tcaaagtaac ctttcttctc ctggccgaca gtccggggaa tgcggatgct ggcactgcga 12540 ttggcgacac cagcagaaaa gtcgttgatg ttggacgttt cgtggaaccc agtcagacga 12600 cgggcattgt ccaggccccc cttgggatcg taggctcgaa tgtggtactg gtgccgcttg 12660 cttagtttct cgatggcctc ctcgatgtgc ttcagaccat tctcctcccg catggccttg 12720 gtgctaaagt tggtatggca gcctgcacca ttccagttcc caggaatggg cttggggtca 12780 aaggttgcta ttaccccaaa gtcctcacat actcgatgca agatgaaacg ggccacccag 12840 agatgatctc ccatgtggat tccttcacag ggtcctattt ggaactccca ctgggcaggc 12900 atgacctcag catttgttcc tgtaatcttg accccagcat acaagcaggc gcggtagtga 12960 gcctccacga tatccctgcc ataggctttg tctgcgccca caccacagta atacggacct 13020 tggggcccag gaaagccatt ggaaggccaa ccaaaagggt gcccatctgt tcccatcaga 13080 gtatactcct gttccattcc aaaccagggg tgctggttgc tcaccatgtc cattatccgt 13140 ttacaggagt gccttaaatt tgtctctgca ggcttccggt tgtacttgaa aacttcacag 13200 aacaccagct tgttgggctc ccggcggaag gggtcccgaa acatggcaac agggctgaga 13260 tacatgtcac tgttggagcc ctcagactga aaggtactag agccatcaaa attccactca 13320 ggtaactctt ctacacactt gggctcacag tccagggtgc gggttttgca gcgcagtcct 13380 tctccagtac catcaaccca gatatacatg gcttggactt tctcaccctg gggcaggcac 13440 aggtacattt gcttgatgtt tttgttcaag tgggaacttg ctgaggtggc catgccaccc 13500 tgcagagtcg ctctgtgttc gaggccacac gcgtcacctt aatatgcgaa gtggacctgg 13560 gaccgcgccg ccccgactgc atctgcgtgt tttcgccaat gacaagacgc tgggcggggt 13620 ttgtgtcatc atagaactaa agacatgcaa atatatttct tccggggaca ccgccagcaa 13680 acgcgagcaa cgggccacgg ggatgaagca gctggaagac tactctggag acgcaacctt 13740 tggagctaag ccagcaatgg tagagggaag attctgcacg tcccttccag gcggcctccc 13800 cgtcaccacc ccccccaacc cgccccgacc ggagctgaga gtaattcata caaaaggact 13860 cgcccctgcc ttggggaatc ccagggaccg tcgttaaact cccactaacg tagaacccag 13920 agatcgctgc gttcccgccc cctcacccgc ccgctctcgt catcactgag gtggagaata 13980 gcatgcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga 14040 gaagttgggg ggaggggtcg gcaattgaac gggtgcctag agaaggtggc gcggggtaaa 14100 ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta 14160 tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca 14220 ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt 14280 gccttgaatt acttccacct ggctccagta cgtgattctt gatcccgagc tggagccagg 14340 ggcgggcctt gcgctttagg agccccttcg cctcgtgctt gagttgaggc ctggcctggg 14400 cgctggggcc gccgcgtgcg aatctggtgg caccttcgcg cctgtctcgc tgctttcgat 14460 aagtctctag ccatttaaaa tttttgatga cgtgctgcga cgcttttttt ctggcaagat 14520 agtcttgtaa atgcgggcca ggatctgcac actggtattt cggtttttgg gcccgcggcc 14580 ggcgacgggg cccgtgcgtc ccagcgcaca tgttcggcga ggcggggcct gcgagcgcgg 14640 ccaccgagaa tcggacgggg gtagtctcaa gctggccggc ctgctctggt gcctggcctc 14700 gcgccgccgt gtatcgcccc gccctgggcg gcaaggctgg cccggtcggc accagttgcg 14760 tgagcggaaa gatggccgct tcccggccct gctccagggg gctcaaaatg gaggacgcgg 14820 cgctcgggag agcgggcggg tgagtcaccc acacaaagga aaagggcctt tccgtcctca 14880 gccgtcgctt catgtgactc cacggagtac cgggcgccgt ccaggcacct cgattagttc 14940 tggagctttt ggagtacgtc gtctttaggt tggggggagg ggttttatgc gatggagttt 15000 ccccacactg agtgggtgga gactgaagtt aggccagctt ggcacttgat gtaattctcc 15060 ttggaatttg gcctttttga gtttggatct tggttcattc tcaagcctca gacagtggtt 15120 caaagttttt ttcttccatt tcaggtgtcg tgaacacgtc tcaggggcag cttgcttgtt 15180 ctttttgcag aagctcagaa taaacgctca actttggccg ccacc 15225 <210> 257 <211> 57 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 257 agcttgcttg ttctttttgc agaagctcag aataaacgct caactttggc cgccacc 57 <210> 258 <211> 166 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 258 gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact 60 tctggctaat aaaggaaatt tattttcatt gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa 120 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 166 <210> 259 <211> 124 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 259 Met Ala Lys Leu Thr Ser Ala Val Pro Val Leu Thr Ala Arg Asp Val 1 5 10 15 Ala Gly Ala Val Glu Phe Trp Thr Asp Arg Leu Gly Phe Ser Arg Asp 20 25 30 Phe Val Glu Asp Asp Phe Ala Gly Val Val Arg Asp Asp Val Thr Leu 35 40 45 Phe Ile Ser Ala Val Gln Asp Gln Val Val Pro Asp Asn Thr Leu Ala 50 55 60 Trp Val Trp Val Arg Gly Leu Asp Glu Leu Tyr Ala Glu Trp Ser Glu 65 70 75 80 Val Val Ser Thr Asn Phe Arg Asp Ala Ser Gly Pro Ala Met Thr Glu 85 90 95 Ile Gly Glu Gln Pro Trp Gly Arg Glu Phe Ala Leu Arg Asp Pro Ala 100 105 110 Gly Asn Cys Val His Phe Val Ala Glu Glu Gln Asp 115 120 <210> 260 <211> 152 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 260 Met Val Ala Ile Ser Lys Asn Gly Val Ile Gly Asn Gly Pro Asp Ile 1 5 10 15 Pro Trp Ser Ala Lys Gly Glu Gln Leu Leu Phe Lys Ala Ile Thr Tyr 20 25 30 Asn Gln Trp Leu Leu Val Gly Arg Lys Thr Phe Glu Ser Met Gly Ala 35 40 45 Leu Pro Asn Arg Lys Tyr Ala Val Val Thr Arg Ser Ser Phe Thr Ser 50 55 60 Asp Asn Glu Asp Val Leu Ile Phe Pro Ser Ile Lys Asp Ala Leu Thr 65 70 75 80 Asn Leu Lys Lys Ile Thr Asp His Val Ile Val Ser Gly Gly Gly Glu 85 90 95 Ile Tyr Lys Ser Leu Ile Asp Gln Val Asp Thr Leu His Ile Ser Thr 100 105 110 Ile Asp Ile Glu Pro Glu Gly Asp Val Tyr Phe Pro Glu Ile Pro Ser 115 120 125 Asn Phe Arg Pro Val Phe Thr Gln Asp Phe Ala Ser Asn Ile Asn Tyr 130 135 140 Ser Tyr Gln Ile Trp Gln Lys Gly 145 150 <210> 261 <211> 187 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 261 Met Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 1 5 10 15 Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 20 25 30 Lys Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 35 40 45 Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 50 55 60 Asn Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu 65 70 75 80 Lys Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp 85 90 95 Ala Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met 100 105 110 Val Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln 115 120 125 Pro Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu 130 135 140 Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu 145 150 155 160 Pro Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile 165 170 175 Lys Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp 180 185 <210> 262 <211> 264 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 262 Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 1 5 10 15 Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 20 25 30 Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 35 40 45 Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 50 55 60 Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 65 70 75 80 Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 85 90 95 Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 100 105 110 Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 115 120 125 Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 130 135 140 Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 145 150 155 160 Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 165 170 175 Ser Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 180 185 190 Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 195 200 205 Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 210 215 220 Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 225 230 235 240 Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 245 250 255 Tyr Arg Leu Leu Asp Glu Phe Phe 260 <210> 263 <211> 267 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 263 Met Gly Ser Ala Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala 1 5 10 15 Ala Trp Val Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile 20 25 30 Gly Cys Ser Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro 35 40 45 Val Leu Phe Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln 50 55 60 Asp Glu Ala Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys 65 70 75 80 Ala Ala Val Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu 85 90 95 Leu Gly Glu Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro 100 105 110 Ala Glu Lys Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr 115 120 125 Leu Asp Pro Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile 130 135 140 Glu Arg Ala Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp 145 150 155 160 Leu Asp Glu Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg 165 170 175 Leu Lys Ala Arg Met Pro Asp Gly Asp Asp Leu Val Val Thr His Gly 180 185 190 Asp Ala Cys Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly 195 200 205 Phe Ile Asp Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile 210 215 220 Ala Leu Ala Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala 225 230 235 240 Asp Arg Phe Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg 245 250 255 Ile Ala Phe Tyr Arg Leu Leu Asp Glu Phe Phe 260 265 <210> 264 <211> 264 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 264 Met Ile Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 1 5 10 15 Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 20 25 30 Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 35 40 45 Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 50 55 60 Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 65 70 75 80 Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 85 90 95 Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 100 105 110 Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 115 120 125 Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 130 135 140 Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 145 150 155 160 Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 165 170 175 Arg Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 180 185 190 Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 195 200 205 Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 210 215 220 Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 225 230 235 240 Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 245 250 255 Tyr Arg Leu Leu Asp Glu Phe Phe 260 <210> 265 <211> 264 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 265 Met Val Glu Gln Asp Gly Leu His Ala Gly Ser Pro Ala Ala Trp Val 1 5 10 15 Glu Arg Leu Phe Gly Tyr Asp Trp Ala Gln Gln Thr Ile Gly Cys Ser 20 25 30 Asp Ala Ala Val Phe Arg Leu Ser Ala Gln Gly Arg Pro Val Leu Phe 35 40 45 Val Lys Thr Asp Leu Ser Gly Ala Leu Asn Glu Leu Gln Asp Glu Ala 50 55 60 Ala Arg Leu Ser Trp Leu Ala Thr Thr Gly Val Pro Cys Ala Ala Val 65 70 75 80 Leu Asp Val Val Thr Glu Ala Gly Arg Asp Trp Leu Leu Leu Gly Glu 85 90 95 Val Pro Gly Gln Asp Leu Leu Ser Ser His Leu Ala Pro Ala Glu Lys 100 105 110 Val Ser Ile Met Ala Asp Ala Met Arg Arg Leu His Thr Leu Asp Pro 115 120 125 Ala Thr Cys Pro Phe Asp His Gln Ala Lys His Arg Ile Glu Arg Ala 130 135 140 Arg Thr Arg Met Glu Ala Gly Leu Val Asp Gln Asp Asp Leu Asp Glu 145 150 155 160 Glu His Gln Gly Leu Ala Pro Ala Glu Leu Phe Ala Arg Leu Lys Ala 165 170 175 Arg Met Pro Asp Gly Glu Asp Leu Val Val Thr His Gly Asp Ala Cys 180 185 190 Leu Pro Asn Ile Met Val Glu Asn Gly Arg Phe Ser Gly Phe Ile Asp 195 200 205 Cys Gly Arg Leu Gly Val Ala Asp Arg Tyr Gln Asp Ile Ala Leu Ala 210 215 220 Thr Arg Asp Ile Ala Glu Glu Leu Gly Gly Glu Trp Ala Asp Arg Phe 225 230 235 240 Leu Val Leu Tyr Gly Ile Ala Ala Pro Asp Ser Gln Arg Ile Ala Phe 245 250 255 Tyr Arg Leu Leu Asp Glu Phe Phe 260 <210> 266 <211> 341 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 266 Met Asp Arg Ser Gly Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys 1 5 10 15 Phe Leu Ile Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser 20 25 30 Glu Gly Glu Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly 35 40 45 Tyr Val Leu Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg 50 55 60 Tyr Val Tyr Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val 65 70 75 80 Leu Asp Ile Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg 85 90 95 Arg Ala Gln Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro 100 105 110 Ala Val Leu Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala 115 120 125 Asp Leu Ser Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile 130 135 140 Gly Gln Tyr Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro 145 150 155 160 His Val Tyr His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser 165 170 175 Val Ala Gln Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro 180 185 190 Glu Val Arg His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu 195 200 205 Thr Asp Asn Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met 210 215 220 Phe Gly Asp Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro 225 230 235 240 Trp Leu Ala Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His 245 250 255 Pro Glu Leu Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile 260 265 270 Gly Leu Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp 275 280 285 Ala Ala Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala 290 295 300 Gly Thr Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp 305 310 315 320 Thr Asp Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro 325 330 335 Ser Thr Arg Pro Arg 340 <210> 267 <211> 341 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 267 Met Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu Ile 1 5 10 15 Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly Glu 20 25 30 Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val Leu 35 40 45 Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val Tyr 50 55 60 Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp Ile 65 70 75 80 Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala Gln 85 90 95 Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val Leu 100 105 110 Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu Ser 115 120 125 Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln Tyr 130 135 140 Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val Tyr 145 150 155 160 His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala Gln 165 170 175 Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val Arg 180 185 190 His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp Asn 195 200 205 Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly Asp 210 215 220 Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu Ala 225 230 235 240 Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu Leu 245 250 255 Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu Asp 260 265 270 Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala Trp 275 280 285 Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr Val 290 295 300 Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp Gly 305 310 315 320 Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr Arg 325 330 335 Pro Arg Ala Lys Glu 340 <210> 268 <211> 199 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 268 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Arg 35 40 45 Ala Ala Arg Thr Leu Pro His Ala Arg Arg Ala Arg His Arg Gln Gly 50 55 60 Val Gly Arg Ala Thr Arg Arg Arg Gly Gly Gly Leu Asp His Ala Gly 65 70 75 80 Glu Arg Arg Ser Gly Gly Gly Val Arg Arg Asp Arg Asn Ala His Gly 85 90 95 Arg Val Glu Arg Phe Pro Ala Gly Arg Ala Ala Thr Asp Gly Arg Pro 100 105 110 Pro Gly Ala Ala Pro Ala Gln Gly Ala Arg Val Val Pro Gly His Arg 115 120 125 Arg Arg Leu Ala Arg Pro Pro Gly Gln Gly Ser Gly Gln Arg Arg Arg 130 135 140 Ala Pro Arg Ser Gly Gly Gly Arg Ala Arg Arg Gly Ala Arg Leu Pro 145 150 155 160 Gly Asp Leu Arg Ala Pro Gln Pro Pro Phe Tyr Glu Arg Leu Gly Phe 165 170 175 Thr Val Thr Ala Asp Val Glu Cys Pro Lys Asp Arg Ala Thr Trp Cys 180 185 190 Met Thr Arg Lys Pro Gly Ala 195 <210> 269 <211> 199 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 269 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 130 135 140 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 145 150 155 160 Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 165 170 175 Thr Val Thr Ala Asp Val Glu Cys Pro Lys Asp Arg Ala Thr Trp Cys 180 185 190 Met Thr Arg Lys Pro Gly Ala 195 <210> 270 <211> 199 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 270 Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 1 5 10 15 Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 20 25 30 Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 35 40 45 Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 50 55 60 Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 65 70 75 80 Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 85 90 95 Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 100 105 110 Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 115 120 125 Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 130 135 140 Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 145 150 155 160 Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 165 170 175 Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 180 185 190 Met Thr Arg Lys Pro Gly Ala 195 <210> 271 <211> 600 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 271 atgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta 60 cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac 120 cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgat 180 ataggtaagg tatgggtggc ggacgacggc gccgcggtgg cggtctggac cacgccggag 240 agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt 300 tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag 360 cccgcgtggt tcctggccac cgtcggcgtg tcgcccgacc accagggcaa gggtctgggc 420 agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg 480 gagacatccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc 540 gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga 600 <210> 272 <211> 132 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 272 Met Ala Lys Pro Leu Ser Gln Glu Glu Ser Thr Leu Ile Glu Arg Ala 1 5 10 15 Thr Ala Thr Ile Asn Ser Ile Pro Ile Ser Glu Asp Tyr Ser Val Ala 20 25 30 Ser Ala Ala Leu Ser Ser Asp Gly Arg Ile Phe Thr Gly Val Asn Val 35 40 45 Tyr His Phe Thr Gly Gly Pro Cys Ala Glu Leu Val Val Leu Gly Thr 50 55 60 Ala Ala Ala Ala Ala Ala Gly Asn Leu Thr Cys Ile Val Ala Ile Gly 65 70 75 80 Asn Glu Asn Arg Gly Ile Leu Ser Pro Cys Gly Arg Cys Arg Gln Val 85 90 95 Leu Leu Asp Leu His Pro Gly Ile Lys Ala Ile Val Lys Asp Ser Asp 100 105 110 Gly Gln Pro Thr Ala Val Gly Ile Arg Glu Leu Leu Pro Ser Gly Tyr 115 120 125 Val Trp Glu Gly 130 <210> 273 <211> 399 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 273 atggccaagc ctttgtctca agaagaatcc accctcattg aaagagcaac ggctacaatc 60 aacagcatcc ccatctctga agattacagc gtcgccagcg cagctctctc tagcgacggc 120 cgcatcttca ctggtgtcaa tgtatatcat tttactgggg gaccttgtgc agaactcgtg 180 gtgctgggca ctgctgctgc tgcggcagct ggcaacctga cttgtatcgt cgcgatcgga 240 aatgagaaca ggggcatctt gagcccctgc ggacggtgcc gacaggtgct tctcgatctg 300 catcctggga tcaaagccat agtgaaggac agtgatggac agccgacggc agttgggatt 360 cgtgaattgc tgccctctgg ttatgtgtgg gagggctaa 399 <210> 274 <211> 373 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 274 Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Asn Ile Lys Gln Met 1 5 10 15 Tyr Leu Cys Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 20 25 30 Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 35 40 45 Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 50 55 60 Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Ser 65 70 75 80 Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 85 90 95 Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 100 105 110 Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 115 120 125 Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 130 135 140 His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 145 150 155 160 Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 165 170 175 Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 180 185 190 Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 195 200 205 Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 210 215 220 Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 225 230 235 240 Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 245 250 255 Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys His Ile Glu Glu 260 265 270 Ala Ile Glu Lys Leu Ser Lys Arg His Arg Tyr His Ile Arg Ala Tyr 275 280 285 Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 290 295 300 Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 305 310 315 320 Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 325 330 335 Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ala Val Thr 340 345 350 Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 355 360 365 Phe Gln Tyr Lys Asn 370 <210> 275 <211> 373 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 275 Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 1 5 10 15 Tyr Met Asn Leu Pro Gln Gly Glu Lys Ile Gln Leu Met Tyr Ile Trp 20 25 30 Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 35 40 45 Cys Asp Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 50 55 60 Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 65 70 75 80 Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Asp Pro Asn Lys Leu 85 90 95 Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 100 105 110 Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Ser Gln His 115 120 125 Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 130 135 140 His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 145 150 155 160 Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 165 170 175 Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Lys Ile Thr Gly 180 185 190 Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 195 200 205 Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 210 215 220 Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 225 230 235 240 Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 245 250 255 Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Arg Cys Ile Glu Glu 260 265 270 Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 275 280 285 Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 290 295 300 Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 305 310 315 320 Ala Ser Ile Arg Ile Pro Arg Ile Val Gly Gln Glu Lys Lys Gly Tyr 325 330 335 Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 340 345 350 Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 355 360 365 Phe Gln Tyr Lys Asn 370 <210> 276 <211> 373 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 276 Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 1 5 10 15 Tyr Met Ser Leu Pro Gln Gly Glu Lys Ile Gln Ala Met Tyr Ile Trp 20 25 30 Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 35 40 45 Cys Asp Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 50 55 60 Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu His 65 70 75 80 Pro Val Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 85 90 95 Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 100 105 110 Leu Arg His Ile Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 115 120 125 Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 130 135 140 His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 145 150 155 160 Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 165 170 175 Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 180 185 190 Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 195 200 205 Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Ile Ala Arg Phe Ile 210 215 220 Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 225 230 235 240 Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 245 250 255 Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Cys Ile Glu Glu 260 265 270 Ala Ile Asp Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 275 280 285 Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 290 295 300 Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 305 310 315 320 Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 325 330 335 Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Tyr Ala Val Thr 340 345 350 Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 355 360 365 Phe Gln Tyr Lys Asn 370 <210> 277 <211> 373 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 277 Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Asn Ile Lys Gln Met 1 5 10 15 Tyr Leu Cys Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 20 25 30 Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 35 40 45 Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 50 55 60 Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Ser 65 70 75 80 Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Glu Pro Asn Lys Leu 85 90 95 Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 100 105 110 Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 115 120 125 Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 130 135 140 His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 145 150 155 160 Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 165 170 175 Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 180 185 190 Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 195 200 205 Cys Glu Gly Ile His Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 210 215 220 Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 225 230 235 240 Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 245 250 255 Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys His Ile Glu Glu 260 265 270 Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 275 280 285 Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 290 295 300 Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 305 310 315 320 Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 325 330 335 Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ala Val Thr 340 345 350 Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 355 360 365 Phe Gln Tyr Lys Asn 370 <210> 278 <211> 394 <212> PRT <213> Artificial sequence <220> <223> Synthetic <400> 278 Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Asn Ile Lys Gln Met 1 5 10 15 Tyr Leu Cys Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 20 25 30 Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 35 40 45 Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 50 55 60 Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Ser 65 70 75 80 Pro Val Ala Met Phe Arg Asp Pro Phe Arg Arg Glu Pro Asn Lys Leu 85 90 95 Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 100 105 110 Leu Arg His Ser Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 115 120 125 Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 130 135 140 His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 145 150 155 160 Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 165 170 175 Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 180 185 190 Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 195 200 205 Cys Glu Gly Ile His Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 210 215 220 Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 225 230 235 240 Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 245 250 255 Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys His Ile Glu Glu 260 265 270 Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 275 280 285 Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 290 295 300 Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 305 310 315 320 Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 325 330 335 Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ala Val Thr 340 345 350 Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 355 360 365 Phe Gln Tyr Lys Asn Trp Ile Arg Ser Asp Met Ile Arg Tyr Ile Asp 370 375 380 Glu Phe Gly Gln Thr Thr Thr Arg Met Gln 385 390 <210> 279 <211> 1122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 279 atggccacct cagcaagttc ccacttgaac aaaaacatca agcaaatgta cttgtgcctg 60 ccccagggtg agaaagtcca agccatgtat atctgggttg atggtactgg agaaggactg 120 cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg tagaagagtt acctgagtgg 180 aattttgatg gctctagtac ctttcagtct gagggctcca acagtgacat gtatctcagc 240 cctgttgcca tgtttcggga ccccttccgc agagatccca acaagctggt gttctgtgaa 300 gttttcaagt acaaccggaa gcctgcagag actaatttaa ggcactcgtg taaacggata 360 atggacatgg tgagcaacca gcacccctgg tttggaatgg aacaggagta tactctgatg 420 ggaacagatg ggcacccttt tggttggcct tccaatggct ttcctgggcc ccaaggtccg 480 tattactgtg gtgtgggcgc agacaaagcc tatggcaggg atatcgtgga ggctcactac 540 cgcgcctgct tgtatgctgg ggtcaagatt acaggaacaa atgctgaggt catgcctgcc 600 cagtgggagt tccaaatagg accctgtgaa ggaatccgca tgggagatca tctctgggtg 660 gcccgtttca tcttgcatcg agtatgtgag gactttgggg taatagcaac ctttgacccc 720 aagcccattc ctgggaactg gaatggtgca ggctgccata ccaactttag caccaaggcc 780 atgcgggagg agaatggtct gaagcacatc gaggaggcca tcgagaaact aagcaagcgg 840 caccggtacc acattcgagc ctacgatccc aaggggggcc tggacaatgc ccgtcgtctg 900 actgggttcc acgaaacgtc caacatcaac gacttttctg ctggtgtcgc caatcgcagt 960 gccagcatcc gcattccccg gactgtcggc caggagaaga aaggttactt tgaagatcgc 1020 cgcccctctg ccaattgtga cccctttgca gtgacagaag ccatcgtccg cacatgcctt 1080 ctcaatgaga ctggcgacga gcccttccaa tacaaaaact aa 1122 <210> 280 <211> 1122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 280 atggccacct cagcaagttc ccacttgaac aaaggaatca agcaaatgta catgaacctg 60 ccccagggtg agaaaatcca actgatgtat atctgggttg atggtactgg agaaggactg 120 cgctgcaaaa cccgcaccct ggactgtgac cccaagtgtg tagaagagtt acctgagtgg 180 aattttgatg gctctagtac ctttcagtct gagggctcca acagtgacat gtatctccac 240 cctgttgcca tgtttcggga ccccttccgc agagatccca acaagctggt gttctgtgaa 300 gttttcaagt acaaccggaa gcctgcagag acaaatttaa ggcactcgtg taaacggata 360 atggacatgg tgagctccca gcacccctgg tttggaatgg aacaggagta tactctgatg 420 ggaacagatg ggcacccttt tggttggcct tccaatggct ttcctgggcc ccaaggtccg 480 tattactgtg gtgtgggcgc agacaaagcc tatggcaggg atatcgtgga ggctcactac 540 cgcgcctgct tgtatgctgg gatcaagatt acaggaacaa atgctgaggt catgcctgcc 600 cagtgggagt tccaaatagg accctgtgaa ggaatccgca tgggagatca tctctgggtg 660 gcccgtttca tcttgcatcg agtatgtgag gactttgggg taatagcaac ctttgacccc 720 aagcccattc ctgggaactg gaatggtgca ggctgccata ccaactttag caccaaggcc 780 atgcgggagg agaatggtct gcggtgcatc gaggaggcca tcgacaaact aagcaagcgg 840 caccagtacc acattcgagc ctacgatccc aaggggggcc tggacaatgc ccgtcgtctg 900 actgggttcc acgaaacgtc caacatcaac gacttttctg ctggtgtcgc caatcgcagt 960 gccagcatcc gcattccccg gatcgtcggc caggagaaga aaggttactt tgaagatcgc 1020 cgcccctctg ccaattgtga cccctacgca gtgacagaag ccatcgtccg cacatgcctt 1080 ctcaatgaga ctggcgacga gcccttccaa tacaaaaact aa 1122 <210> 281 <211> 1122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 281 atggccacct cagcaagttc ccacttgaac aaaggcatca agcaaatgta catgtccctg 60 ccccagggtg agaaaatcca agccatgtat atctgggttg atggtaccgg agaaggactg 120 cgctgcaaga cccgtaccct ggactgtgac cccaagtgtg tggaagagtt acctgagtgg 180 aactttgatg gctctagtac ctttcagtct gaaggctcca acagcgacat gtacctccat 240 cctgttgcca tgtttcggga ccccttccgc aaagacccca acaagctggt gctatgtgaa 300 gttttcaagt ataaccggaa gcctgcagaa accaacttga ggcacatctg taaacggata 360 atggacatgg tgagcaacca gcacccctgg tttggaatgg agcaggaata tactcttatg 420 ggaacagacg gccacccatt tggttggcct tccaatggct tccctggacc ccaaggcccg 480 tattactgcg gtgtgggagc agacaaggcc tacggcaggg acatcgtgga ggctcactac 540 cgggcctgct tgtatgctgg agtcaagatc acggggacaa atgcggaggt tatgcctgcc 600 cagtgggaat tccagatagg accctgtgag ggaatccgaa tgggagatca tctttggata 660 gcccgtttta tcttgcatcg ggtgtgcgaa gattttgggg tgatagcaac ctttgacccc 720 aagcccattc cagggaactg gaatggtgca ggctgccata ccaacttcag caccaaggcc 780 atgcgggagg agaatggtct gaagtgcatt gaggaggcca ttgacaaact gagcaagagg 840 caccagtacc acatccgcgc ctacgatccc aaggggggcc tggacaacgc ccggcgtctg 900 actggattcc acgaaacctc caacatcaac gacttttctg ccggtgttgc caaccgctcc 960 gccagtatcc gcattccccg gactgtcggc caggagaaga agggctactt tgaggaccgt 1020 cggccttctg ccaattgtga cccctatgcg gtgacagaag ccatcgtccg cacgtgtctc 1080 ctcaacgaaa caggcgacga acccttccaa tacaagaact aa 1122 <210> 282 <211> 1122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 282 atggccacct cagcaagttc ccacttgaac aaaaacatca agcaaatgta cctgtgcctg 60 ccccagggtg agaaagtcca agccatgtat atctgggttg atggtactgg agaaggactg 120 cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg tagaagagtt acctgagtgg 180 aattttgatg gctctagtac ctttcagtct gagggctcca acagtgacat gtatctcagc 240 cctgttgcca tgtttcggga ccccttccgc cgggagccca acaagctggt gttctgtgaa 300 gttttcaagt acaaccggaa gcctgcagag acaaatttaa ggcactcctg taaacggata 360 atggacatgg tgagcaacca gcacccctgg tttggaatgg aacaggagta tactctgatg 420 ggaacagatg ggcacccttt tggttggcct tccaatggct ttcctgggcc ccaaggtccg 480 tattactgtg gtgtgggcgc agacaaagcc tatggcaggg atatcgtgga ggctcactac 540 cgcgcctgct tgtatgctgg ggtcaagatt acaggaacaa atgctgaggt catgcctgcc 600 cagtgggagt tccaaatagg accctgtgaa ggaatccaca tgggagatca tctctgggtg 660 gcccgtttca tcttgcatcg agtatgtgag gactttgggg taatagcaac ctttgacccc 720 aagcccattc ctgggaactg gaatggtgca ggctgccata ccaactttag caccaaggcc 780 atgcgggagg agaatggtct gaagcacatc gaggaggcca tcgagaaact aagcaagcgg 840 caccagtacc acattcgagc ctacgatccc aaggggggcc tggacaatgc ccgtcgtctg 900 actgggttcc acgaaacgtc caacatcaac gacttttctg ctggtgtcgc caatcgcagt 960 gccagcatcc gcattccccg gactgtcggc caggagaaga aaggttactt tgaagatcgc 1020 cgcccctctg ccaattgtga cccctttgca gtgacagaag ccatcgtccg cacatgcctt 1080 ctcaatgaga ctggcgacga gcccttccaa tacaaaaact aa 1122 <210> 283 <211> 1228 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 283 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ttcgaccatt gaactgcatc gtcgccgtgt cccaaaatat ggggattggc aagaacggag 480 atcttccctg gcctccgctc aggaacgagt tcaagtactt ccaaagaatg accacaacct 540 cttcagtgga aggtaaacag aatctggtga ttatgggtag gaaaacctgg ttctccattc 600 ctgagaagaa tcgaccttta aaggacagaa ttaatatagt tctcagtaga gaactcaaag 660 aaccaccacg aggagctcat tttcttgcca aaagtttgga tgatgcctta agacttattg 720 aacaaccgga attggcaagt aaagtagaca tggtttggat agtcggaggc agttctgttt 780 accaggaagc catgaatcaa ccaggccacc tcagactctt tgtgacaagg atcatgcagg 840 aatttgaaag tgacacgttt ttcccagaaa ttgatttggg gaaatataaa cttctcccag 900 aatacccagg cgtcctctct gaggtccagg aggaaaaagg catcaagtat aagtttgaag 960 tctacgagaa gaaagactaa tggatccgct cagacatgat aagatacatt gatgagtttg 1020 gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta 1080 ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc 1140 attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct 1200 acaaatgtgg taggcgcgcc gaagacaa 1228 <210> 284 <211> 1026 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 284 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaataaat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gatggttcga 240 ccattgaact gcatcgtcgc cgtgtcccaa aatatgggga ttggcaagaa cggagacttg 300 ccctggcctc cgctcaggaa cgagttcaag tacttccaaa gaatgaccac aacctcttca 360 gtggaaggta aacagaatct ggtgattatg ggtaggaaaa cctggttctc cattcctgag 420 aagaatcgac ctttaaagga cagaattaat atagttctca gtagagaact caaagaacca 480 ccacgaggag ctcattttct tgccaaaagt ttggatgatg ccttaagact tattgaacaa 540 ccggaattgg caagtaaagt agacatggtt tggatagtcg gaggcagttc tgtttaccag 600 gaagccatga atcaaccagg ccacctcaga ctctttgtga caaggatcat gcaggaattt 660 gaaagtgaca cgtttttccc agaaattgat ttggggaaat ataaacttct cccagaatac 720 ccaggcgtcc tctctgaggt ccaggaggaa aaaggcatca agtataagtt tgaagtctac 780 gagaagaaag actaatacca catttgtaga ggttttactt gctttaaaaa acctcccaca 840 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 900 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 960 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggga 1020 agacac 1026 <210> 285 <211> 1712 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 285 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gttcgaccat tgaactgcat cgtcgccgtg tcccaaaata tggggattgg caagaacgga 300 gacttgccct ggcctccgct caggaacgag ttcaagtact tccaaagaat gaccacaacc 360 tcttcagtgg aaggtaaaca gaatctggtg attatgggta ggaaaacctg gttctccatt 420 cctgagaaga atcgaccttt aaaggacaga attaatatag ttctcagtag agaactcaaa 480 gaaccaccac gaggagctca ttttcttgcc aaaagtttgg atgatgcctt aagacttatt 540 gaacaaccgg aattggcaag taaagtagac atggtttgga tagtcggagg cagttctgtt 600 taccaggaag ccatgaatca accaggccac ctcagactct ttgtgacaag gatcatgcag 660 gaatttgaaa gtgacacgtt tttcccagaa attgatttgg ggaaatataa acttctccca 720 gaatacccag gcgtcctctc tgaggtccag gaggaaaaag gcatcaagta taagtttgaa 780 gtctacgaga agaaagacta attagacttt gagtgatctt gagcctttcc tagttcatcc 840 caccccgccc cagagagatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg 900 acaaactacc tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat 960 gtgttaaact actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg 1020 aatgggagca gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc 1080 catctagtga tgatgaggct actgctgact ctcaacattc tactcctcca aaaaagaaga 1140 gaaaggtaga agatcccaag gactttcctt cagaattgct aagttttttg agtcatgctg 1200 tgtttagtaa tagaactctt gcttgctttg ctatttacac cacaaaggaa aaagctgcac 1260 tgctatacaa gaaaattatg gaaaaatatt ctgtaacctt tataagtagg cataacagtt 1320 ataatcataa catactgttt tttcttactc cacacaggca tagagtgtct gctattaata 1380 actatgctca aaaattgtgt acctttagct ttttaatttg taaaggggtt aataaggaat 1440 atttgatgta tagtgccttg actagagatc ataatcagcc ataccacatt tgtagaggtt 1500 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 1560 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 1620 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 1680 atcaatgtat cttatcatgt ctgggaagac ac 1712 <210> 286 <211> 1064 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 286 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca ggcctggttg 240 aggaacctgt taagacggct ccgggaaaaa aggttcgacc attgaactgc atcgtcgccg 300 tgtcccaaaa tatggggatt ggcaagaacg gagacttgcc ctggcctccg ctcaggaacg 360 agttcaagta cttccaaaga atgaccacaa cctcttcagt ggaaggtaaa cagaatctgg 420 tgattatggg taggaaaacc tggttctcca ttcctgagaa gaatcgacct ttaaaggaca 480 gaattaatat agttctcagt agagaactca aagaaccacc acgaggagct cattttcttg 540 ccaaaagttt ggatgatgcc ttaagactta ttgaacaacc ggaattggca agtaaagtag 600 acatggtttg gatagtcgga ggcagttctg tttaccagga agccatgaat caaccaggcc 660 acctcagact ctttgtgaca aggatcatgc aggaatttga aagtgacacg tttttcccag 720 aaattgattt ggggaaatat aaacttctcc cagaataccc aggcgtcctc tctgaggtcc 780 aggaggaaaa aggcatcaag tataagtttg aagtctacga gaagaaagac taataccaca 840 tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat 900 aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa 960 agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt 1020 ttgtccaaac tcatcaatgt atcttatcat gtctgggaag acac 1064 <210> 287 <211> 1358 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 287 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gtaaggccac tgaactgtat tgtggcggta agtcagaaca tgggtatagg taagaatggt 300 gacttgcctt ggcctccgct tcggaacgaa ttcaagtatt tccaacgcat gactactacc 360 tcaagtgtgg aaggtaagca aaatctggta attatgggac gtaagacctg gttttccatt 420 cccgaaaaga acaggccact caaggaccgg atcaacatcg tgctctcgcg agaactgaag 480 gagcccccgc gaggtgcgca cttcctggca aagtcactgg acgacgccct gcggctgatt 540 gagcagccag agctggcaag taaggtagat atggtatgga tagtaggtgg gtcaagtgtg 600 tatcaggagg cgatgaacca gccaggtcac ttgaggttgt ttgtgactcg gatcatgcaa 660 gagttcgagt cagacacttt cttccccgag atcgacctag gtaagtacaa gttactgcca 720 gagtacccag gtgtgttaag tgaggtgcaa gaggaaaaag gtatcaagta caagttcgag 780 gtatatgaaa agaaggatta attagacttt gagtgatctt gagcctttcc tagttcatcc 840 caccccgccc cagagagatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg 900 acaaactacc tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat 960 gtgttaaact actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg 1020 aatgggagca gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc 1080 catctagtga tgatgaggct actgctgact ctcaacattc tactccttac cacatttgta 1140 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 1200 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 1260 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 1320 aaactcatca atgtatctta tcatgtctgg gaagacac 1358 <210> 288 <211> 1358 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 288 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gtaaggccac tgaactgtat tgtggcggta agtcagaaca tgggtatagg taagaatggt 300 gacttgcctt ggcctccgct tcggaacgaa ttcaagtatt tccaacgcat gactactacc 360 tcaagtgtgg aaggtaagca aaatctggta attatgggac gtaagacctg gttttccatt 420 cccgaaaaga acaggccact caaggaccgg atcaacatcg tgctctcgcg agaactgaag 480 gagcccccgc gaggtgcgca cttcctggca aagtcactgg acgacgccct gcggctgatt 540 gagcagccag agctggcaag taaggtagat atggtatgga tagtaggtgg gtcaagtgtg 600 tatcaggagg cgatgaacca gccaggtcac ttgaggttgt ttgtgactcg gatcatgcaa 660 gagttcgagt cagacacttt cttccccgag atcgacctag gtaagtacaa gttactgcca 720 gagtacccag gtgtgttaag tgaggtgcaa gaggaaaaag gcatcaagta caagttcgag 780 gtatatgaaa agaaggatta attagacttt gagtgatctt gagcctttcc tagttcatcc 840 caccccgccc cagagagatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg 900 acaaactacc tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat 960 gtgttaaact actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg 1020 aatgggagca gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc 1080 catctagtga tgatgaggct actgctgact ctcaacattc tactccttac cacatttgta 1140 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 1200 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 1260 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 1320 aaactcatca atgtatctta tcatgtctgg gaagacac 1358 <210> 289 <211> 1712 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 289 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gttcgaccat tgaactgcat cgtcgccgtg tcccaaaata tggggattgg caagaacgga 300 gacttgccct ggcctccgct caggaacgag ttcaagtact tccaaagaat gaccacaacc 360 tcttcagtgg aaggtaaaca gaatctggtg attatgggta ggaaaacctg gttctccatt 420 cctgagaaga atcgaccttt aaaggacaga attaatatag ttctcagtag agaactcaaa 480 gaaccaccac gaggagctca ttttcttgcc aaaagtttgg atgatgcctt aagacttatt 540 gaacaaccgg aattggcaag taaagtagac atggtttgga tagtcggagg cagttctgtt 600 taccaggaag ccatgaatca accaggccac ctcagactct ttgtgacaag gatcatgcag 660 gaatttgaaa gtgacacgtt tttcccagaa attgatttgg ggaaatataa acttctccca 720 gagtacccag gtgtgttaag tgaggtgcaa gaggaaaaag gtatcaagta caagttcgag 780 gtatatgaaa agaaggatta attagacttt gagtgatctt gagcctttcc tagttcatcc 840 caccccgccc cagagagatc tttgtgaagg aaccttactt ctgtggtgtg acataattgg 900 acaaactacc tacagagatt taaagctcta aggtaaatat aaaattttta agtgtataat 960 gtgttaaact actgattcta attgtttgtg tattttagat tccaacctat ggaactgatg 1020 aatgggagca gtggtggaat gcctttaatg aggaaaacct gttttgctca gaagaaatgc 1080 catctagtga tgatgaggct actgctgact ctcaacattc tactcctcca aaaaagaaga 1140 gaaaggtaga agatcccaag gactttcctt cagaattgct aagttttttg agtcatgctg 1200 tgtttagtaa tagaactctt gcttgctttg ctatttacac cacaaaggaa aaagctgcac 1260 tgctatacaa gaaaattatg gaaaaatatt ctgtaacctt tataagtagg cataacagtt 1320 ataatcataa catactgttt tttcttactc cacacaggca tagagtgtct gctattaata 1380 actatgctca aaaattgtgt acctttagct ttttaatttg taaaggggtt aataaggaat 1440 atttgatgta tagtgccttg actagagatc ataatcagcc ataccacatt tgtagaggtt 1500 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 1560 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 1620 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 1680 atcaatgtat cttatcatgt ctgggaagac ac 1712 <210> 290 <211> 1541 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 290 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gagatatgtt tgagaatacc actttatccc gcgtcaggga gaggcagtgc 300 gtaaaaagac gcggactcat gtgaaatact ggtttttagt gcgccagatc tcatctcgcg 360 caacctattt tcccctcgaa cactttttaa gccgtagata aacaggctgg gacacttcac 420 atggtaaggc cactgaactg tattgtggcg gtaagtcaga acatgggtat aggtaagaat 480 ggtgacttgc cttggcctcc gcttcggaac gaattcaagt atttccaacg catgactact 540 acctcaagtg tggaaggtaa gcaaaatctg gtaattatgg gacgtaagac ctggttttcc 600 attcccgaaa agaacaggcc actcaaggac cggatcaaca tcgtgctctc gcgagaactg 660 aaggagcccc cgcgaggtgc gcacttcctg gcaaagtcac tggacgacgc cctgcggctg 720 attgagcagc cagagctggc aagtaaggta gatatggtat ggatagtagg tgggtcaagt 780 gtgtatcagg aggcgatgaa ccagccaggt cacttgaggt tgtttgtgac tcggatcatg 840 caagagttcg agtcagacac tttcttcccc gagatcgacc taggtaagta caagttactg 900 ccagagtacc caggtgtgtt aagtgaggtg caagaggaaa aaggtatcaa gtacaagttc 960 gaggtatatg aaaagaagga ttaattagac tttgagtgat cttgagcctt tcctagttca 1020 tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt gtgacataat 1080 tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt ttaagtgtat 1140 aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc tatggaactg 1200 atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc tcagaagaaa 1260 tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct taccacattt 1320 gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa 1380 atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc 1440 aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 1500 tccaaactca tcaatgtatc ttatcatgtc tgggaagaca c 1541 <210> 291 <211> 1321 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 291 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ttcgaccatt gaactgcatc gtcgccgtgt cccaaaatat ggggattggc aagaacggag 480 atcttccctg gcctccgctc aggaacgagt tcaagtactt ccaaagaatg accacaacct 540 cttcagtgga aggtaaacag aatctggtga ttatgggtag gaaaacctgg ttctccattc 600 ctgagaagaa tcgaccttta aaggacagaa ttaatatagt tctcagtaga gaactcaaag 660 aaccaccacg aggagctcat tttcttgcca aaagtttgga tgatgcctta agacttattg 720 aacaaccgga attggcaagt aaagtagaca tggtttggat agtcggaggc agttctgttt 780 accaggaagc catgaatcaa ccaggccacc tcagactctt tgtgacaagg atcatgcagg 840 aatttgaaag tgacacgttt ttcccagaaa ttgatttggg gaaatataaa cttctcccag 900 aatacccagg cgtcctctct gaggtccagg aggaaaaagg catcaagtat aagtttgaag 960 tctacgagaa gaaagactaa tggatccgcc cacagacctg gtgaccgtca ggaagaagat 1020 tcagtgagag gacacgaggt atgtcatggt ttttaatcaa taaataaaga ggttttattc 1080 atcggacagt cgttgtagcc tgtaaaagac tcgccccgga gggggttccc ccgatgtgag 1140 gggcatgcag tagtatggtg tcctgagtgt ctcggatgcg tccttgaact cgcactctac 1200 cgccgtgggg gttaataaag ttttgctgcg ccggtagggg gggaggccga ggataataaa 1260 gttgctacgt actggttgaa gtctaacaat ctctcggggg gatccggcgc gccgaagaca 1320 a 1321 <210> 292 <211> 1899 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 292 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gagatatgtt tgagaatacc actttatccc gcgtcaggga gaggcagtgc 300 gtaaaaagac gcggactcat gtgaaatact ggtttttagt gcgccagatc tctataatct 360 cgcgcaacct attttcccct cgaacacttt ttaagccgta gataaacagg ctgggacact 420 tcacatggtt cgaccattga actgcatcgt cgccgtgtcc caaaatatgg ggattggcaa 480 gaacggagac ttgccctggc ctccgctcag gaacgagttc aagtacttcc aaagaatgac 540 cacaacctct tcagtggaag gtaaacagaa tctggtgatt atgggtagga aaacctggtt 600 ctccattcct gagaagaatc gacctttaaa ggacagaatt aatatagttc tcagtagaga 660 actcaaagaa ccaccacgag gagctcattt tcttgccaaa agtttggatg atgccttaag 720 acttattgaa caaccggaat tggcaagtaa agtagacatg gtttggatag tcggaggcag 780 ttctgtttac caggaagcca tgaatcaacc aggccacctc agactctttg tgacaaggat 840 catgcaggaa tttgaaagtg acacgttttt cccagaaatt gatttgggga aatataaact 900 tctcccagaa tacccaggcg tcctctctga ggtccaggag gaaaaaggca tcaagtataa 960 gtttgaagtc tacgagaaga aagactaatt agactttgag tgatcttgag cctttcctag 1020 ttcatcccac cccgccccag agagatcttt gtgaaggaac cttacttctg tggtgtgaca 1080 taattggaca aactacctac agagatttaa agctctaagg taaatataaa atttttaagt 1140 gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga 1200 actgatgaat gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa 1260 gaaatgccat ctagtgatga tgaggctact gctgactctc aacattctac tcctccaaaa 1320 aagaagagaa aggtagaaga tcccaaggac tttccttcag aattgctaag ttttttgagt 1380 catgctgtgt ttagtaatag aactcttgct tgctttgcta tttacaccac aaaggaaaaa 1440 gctgcactgc tatacaagaa aattatggaa aaatattctg taacctttat aagtaggcat 1500 aacagttata atcataacat actgtttttt cttactccac acaggcatag agtgtctgct 1560 attaataact atgctcaaaa attgtgtacc tttagctttt taatttgtaa aggggttaat 1620 aaggaatatt tgatgtatag tgccttgact agagatcata atcagccata ccacatttgt 1680 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 1740 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 1800 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 1860 caaactcatc aatgtatctt atcatgtctg ggaagacac 1899 <210> 293 <211> 1049 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 293 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gttcgaccat tgaactgcat cgtcgccgtg tcccaaaata tggggattgg caagaacgga 300 gatcttccct ggcctccgct caggaacgag ttcaagtact tccaaagaat gaccacaacc 360 tcttcagtgg aaggtaaaca gaatctggtg attatgggta ggaaaacctg gttctccatt 420 cctgagaaga atcgaccttt aaaggacaga attaatatag ttctcagtag agaactcaaa 480 gaaccaccac gaggagctca ttttcttgcc aaaagtttgg atgatgcctt aagacttatt 540 gaacaaccgg aattggcaag taaagtagac atggtttgga tagtcggagg cagttctgtt 600 taccaggaag ccatgaatca accaggccac ctcagactct ttgtgacaag gatcatgcag 660 gaatttgaaa gtgacacgtt tttcccagaa attgatttgg ggaaatataa acttctccca 720 gaatacccag gcgtcctctc tgaggtccag gaggaaaaag gcatcaagta taagtttgaa 780 gtctacgaga agaaagacta atggatccgc tcagacatga taagatacat tgatgagttt 840 ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct 900 attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt 960 cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc 1020 tacaaatgtg gtaggcgcgc cgaagacaa 1049 <210> 294 <211> 1472 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 294 aagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggttcgacca ttgaactgca tcgtcgccgt gtcccaaaat atggggattg 720 gcaagaacgg agatcttccc tggcctccgc tcaggaacga gttcaagtac ttccaaagaa 780 tgaccacaac ctcttcagtg gaaggtaaac agaatctggt gattatgggt aggaaaacct 840 ggttctccat tcctgagaag aatcgacctt taaaggacag aattaatata gttctcagta 900 gagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg gatgatgcct 960 taagacttat tgaacaaccg gaattggcaa gtaaagtaga catggtttgg atagtcggag 1020 gcagttctgt ttaccaggaa gccatgaatc aaccaggcca cctcagactc tttgtgacaa 1080 ggatcatgca ggaatttgaa agtgacacgt ttttcccaga aattgatttg gggaaatata 1140 aacttctccc agaataccca ggcgtcctct ctgaggtcca ggaggaaaaa ggcatcaagt 1200 ataagtttga agtctacgag aagaaagact aatggatccg ctcagacatg ataagataca 1260 ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa 1320 tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca 1380 acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca 1440 agtaaaacct ctacaaatgt ggtagaagac aa 1472 <210> 295 <211> 1310 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 295 gtgtcttctt tctttatgtt ttaaatgcac tgatctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtt agtctttctt ctcgtagact 240 tcaaacttat acttgatgcc tttttcctcc tggacctcag agaggacgcc tgggtattct 300 gggagaagtt tatatttccc caaatcaatt tctgggaaaa acgtgtcact ttcaaattcc 360 tgcatgatcc ttgtcacaaa gagtctgagg tggcctggtt gattcatggc ttcctggtaa 420 acagaactgc ctccgactat ccaaaccatg tctactttac ttgccaattc cggttgttca 480 ataagtctta aggcatcatc caaacttttg gcaagaaaat gagctcctcg tggtggttct 540 ttgagttctc tactgagaac tatattaatt ctgtccttta aaggtcgatt cttctcagga 600 atggagaacc aggttttcct acccataatc accagattct gtttaccttc cactgaagag 660 gttgtggtca ttctttggaa gtacttgaac tcgttcctga gcggaggcca gggcaagtct 720 ccgttcttgc caatccccat attttgggac acggcgacga tgcagttcaa tggtcgaacc 780 atggtggcga cgtgcgctcc ggaggcttgc agaatgcgga acaccgcgcg ggcaggaaca 840 gggcccacac taccgcccca caccccgcct cccgcaccgc cccttcccgg ccgctgctct 900 cagaaagcga aggagcaaag ctgctattgg ccgctgcccc aaaggcctac ccgcttccat 960 tgctcagcgg tgctgtccat ctgcacgaga ctagtgagtc gtgctacttc catttgtcac 1020 gtcctgcacg acgcgagctg cggggcgggg gggaacttcc tgactagggg aggagtagaa 1080 ggtggcgcga aggggccacc aaagaacgga gccggttggc gcctaccggt ggatgtggaa 1140 tgtgtgcgag gccagaggcc acttgtgtag cgccaagtgc ccagcggggc tgctaaagcg 1200 catgctccag actgccttgg gaaaagcgcc tcccctaccc ggtagagaaa cttgatctgt 1260 cgccgcaatt caaacttcgt gaggctccgg tgcccgtcag tggaagacta 1310 <210> 296 <211> 1266 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 296 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcactatcag cccttctgcc 240 aaatctggta gctatagttg atgttcgagg cgaagtcttg ggtgaacacc ggcctaaagt 300 tgctcgggat ctcagggaag tacacatctc cttcgggttc gatgtcgatg gtggagatgt 360 gcagagtgtc cacttggtcg atcagtgact tgtagatttc gccccctccg gacacaatga 420 catggtcggt gatcttcttg aggttcgtga gagcgtcctt gatcgaaggg aagatcagca 480 catcctcatt gtcggaagtg aagctggatc tggtcacgac ggcgtatttc cggttcggca 540 gggcacccat ggattcgaaa gtcttgcgac cgacaagcaa ccactggttg taggtgatgg 600 ccttgaacag cagctgctct ccctttgcgg accagggaat atctgggccg ttcccaatca 660 ctccgttctt tgaaatcgcc accatggtgg cggacgaaag gcccggagat gaggaagagg 720 agaacagcgc ggcagacgtg cgcttttgaa gcgtgcagaa tgccgggcct ccggaggacc 780 ttcgggcgcc cgccccgccc ctgagcccgc ccctgagccc gcccccggac ccaccccttc 840 ccagcctctg agcccagaaa gcgaaggagc aaagctgcta ttggccgctg ccccaaaggc 900 ctacccgctt ccattgctca gcggtgctgt ccatctgcac gagactagtg agtcgtgcta 960 cttccatttg tcacgtcctg cacgacgcga gctgcggggc gggggggaac ttcctgacta 1020 ggggaggagt agaaggtggc gcgaaggggc caccaaagaa cggagccggt tggcgcctac 1080 cggtggatgt ggaatgtgtg cgaggccaga ggccacttgt gtagcgccaa gtgcccagcg 1140 gggctgctaa agcgcatgct ccagactgcc ttgggaaaag cgcctcccct acccggtaga 1200 gaaacttgat ctgtcgccgc aattcaaact tcgtgaggct ccggtgcccg tcagtgacct 1260 gctata 1266 <210> 297 <211> 1371 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 297 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcactattag tctttcttct 240 cgtagacttc aaacttatac ttgatgcctt tttcctcctg gacctcagag aggacgcctg 300 ggtattctgg gagaagttta tatttcccca aatcaatttc tgggaaaaac gtgtcacttt 360 caaattcctg catgatcctt gtcacaaaga gtctgaggtg gcctggttga ttcatggctt 420 cctggtaaac agaactgcct ccgactatcc aaaccatgtc tactttactt gccaattccg 480 gttgttcaat aagtcttaag gcatcatcca aacttttggc aagaaaatga gctcctcgtg 540 gtggttcttt gagttctcta ctgagaacta tattaattct gtcctttaaa ggtcgattct 600 tctcaggaat ggagaaccag gttttcctac ccataatcac cagattctgt ttaccttcca 660 ctgaagaggt tgtggtcatt ctttggaagt acttgaactc gttcctgagc ggaggccagg 720 gcaagtctcc gttcttgcca atccccatat tttgggacac ggcgacgatg cagttcaatg 780 gtcgaaccat ggtggcggac gaaaggcccg gagatgagga agaggagaac agcgcggcag 840 acgtgcgctt ttgaagcgtg cagaatgccg ggcctccgga ggaccttcgg gcgcccgccc 900 cgcccctgag cccgcccctg agcccgcccc cggacccacc ccttcccagc ctctgagccc 960 agaaagcgaa ggagcaaagc tgctattggc cgctgcccca aaggcctacc cgcttccatt 1020 gctcagcggt gctgtccatc tgcacgagac tagtgagtcg tgctacttcc atttgtcacg 1080 tcctgcacga cgcgagctgc ggggcggggg ggaacttcct gactagggga ggagtagaag 1140 gtggcgcgaa ggggccacca aagaacggag ccggttggcg cctaccggtg gatgtggaat 1200 gtgtgcgagg ccagaggcca cttgtgtagc gccaagtgcc cagcggggct gctaaagcgc 1260 atgctccaga ctgccttggg aaaagcgcct cccctacccg gtagagaaac ttgatctgtc 1320 gccgcaattc aaacttcgtg aggctccggt gcccgtcagt gacctgctat a 1371 <210> 298 <211> 977 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 298 aagtcttctt aattaatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatggt tcgaccattg 180 aactgcatcg tcgccgtgtc ccaaaatatg gggattggca agaacggaga tcttccctgg 240 cctccgctca ggaacgagtt caagtacttc caaagaatga ccacaacctc ttcagtggaa 300 ggtaaacaga atctggtgat tatgggtagg aaaacctggt tctccattcc tgagaagaat 360 cgacctttaa aggacagaat taatatagtt ctcagtagag aactcaaaga accaccacga 420 ggagctcatt ttcttgccaa aagtttggat gatgccttaa gacttattga acaaccggaa 480 ttggcaagta aagtagacat ggtttggata gtcggaggca gttctgttta ccaggaagcc 540 atgaatcaac caggccacct cagactcttt gtgacaagga tcatgcagga atttgaaagt 600 gacacgtttt tcccagaaat tgatttgggg aaatataaac ttctcccaga atacccaggc 660 gtcctctctg aggtccagga ggaaaaaggc atcaagtata agtttgaagt ctacgagaag 720 aaagactaat ggatccgctc agacatgata agatacattg atgagtttgg acaaaccaca 780 actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt 840 gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt 900 caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt 960 aggcgcgccg aagacaa 977 <210> 299 <211> 1796 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 299 ttgtcttccc cacttctatg atccgcggcc gcatgcatct caattagtca gcaaccatag 60 tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc 120 cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc 180 tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aagcttggac 240 acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc agggagaggc 300 agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc agatctctat 360 aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa acaggctggg 420 acacttcaca tggttcgacc attgaactgc atcgtcgccg tgtcccaaaa tatggggatt 480 ggcaagaacg gagatcttcc ctggcctccg ctcaggaacg agttcaagta cttccaaaga 540 atgaccacaa cctcttcagt ggaaggtaaa cagaatctgg tgattatggg taggaaaacc 600 tggttctcca ttcctgagaa gaatcgacct ttaaaggaca gaattaatat agttctcagt 660 agagaactca aagaaccacc acgaggagct cattttcttg ccaaaagttt ggatgatgcc 720 ttaagactta ttgaacaacc ggaattggca agtaaagtag acatggtttg gatagtcgga 780 ggcagttctg tttaccagga agccatgaat caaccaggcc acctcagact ctttgtgaca 840 aggatcatgc aggaatttga aagtgacacg tttttcccag aaattgattt ggggaaatat 900 aaacttctcc cagaataccc aggcgtcctc tctgaggtcc aggaggaaaa aggcatcaag 960 tataagtttg aagtctacga gaagaaagac taaataatca gccataccac atttgtagag 1020 gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat 1080 gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc 1140 atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa 1200 ctcatcaatg tatcttatca tgtctggatc ctgcctcgcg cgtttcggtg atgacggtga 1260 aaacctcaaa tcgataatat atggtagggt tcatagccag agtaaccttt ttttttaatt 1320 tttattttat tttatttttg agtcgggcgc gccaaaatga agtgaagttc ctatactttc 1380 tagatagact ctgggtagaa tgttctgttt cctgtaatat aaaatcataa agtgatgata 1440 ttatcaagtg aaaaggaaat gtggtacctt aatctttcca catcaagcca atatcatgct 1500 gaaggccaga gaatcttttt tgctaaaaaa cacaatacag atataattaa tagttatcat 1560 ttatgtttga tattaatcat atgaatataa ttaatatgtt ttattgtatc gattattgtt 1620 gatattaatg taattactac taatacataa caaatataac taatggttat ggctcagtaa 1680 ctaaggtaag atataagcta cactggtaaa gaaagatcaa tattgcttca gagtacactg 1740 aagtaaatga ataacttaac cggtctaggt tgtcacttat atttatacga agactt 1796 <210> 300 <211> 1819 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 300 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca ctttatggcc 420 acctcagcaa gttcccactt gaacaaaaac atcaagcaaa tgtacttgtg cctgccccag 480 ggtgagaaag tccaagccat gtatatctgg gttgatggta ctggagaagg actgcgctgc 540 aaaacccgca ccctggactg tgagcccaag tgtgtagaag agttacctga gtggaatttt 600 gatggctcta gtacctttca gtctgagggc tccaacagtg acatgtatct cagccctgtt 660 gccatgtttc gggacccctt ccgcagagat cccaacaagc tggtgttctg tgaagttttc 720 aagtacaacc ggaagcctgc agagactaat ttaaggcact cgtgtaaacg gataatggac 780 atggtgagca accagcaccc ctggtttgga atggaacagg agtatactct gatgggaaca 840 gatgggcacc cttttggttg gccttccaat ggctttcctg ggccccaagg tccgtattac 900 tgtggtgtgg gcgcagacaa agcctatggc agggatatcg tggaggctca ctaccgcgcc 960 tgcttgtatg ctggggtcaa gattacagga acaaatgctg aggtcatgcc tgcccagtgg 1020 gagttccaaa taggaccctg tgaaggaatc cgcatgggag atcatctctg ggtggcccgt 1080 ttcatcttgc atcgagtatg tgaggacttt ggggtaatag caacctttga ccccaagccc 1140 attcctggga actggaatgg tgcaggctgc cataccaact ttagcaccaa ggccatgcgg 1200 gaggagaatg gtctgaagca catcgaggag gccatcgaga aactaagcaa gcggcaccgg 1260 taccacattc gagcctacga tcccaagggg ggcctggaca atgcccgtcg tctgactggg 1320 ttccacgaaa cgtccaacat caacgacttt tctgctggtg tcgccaatcg cagtgccagc 1380 atccgcattc cccggactgt cggccaggag aagaaaggtt actttgaaga tcgccgcccc 1440 tctgccaatt gtgacccctt tgcagtgaca gaagccatcg tccgcacatg ccttctcaat 1500 gagactggcg acgagccctt ccaatacaaa aactggatta gaagcgatat gatcagatat 1560 atcgacgaat tcggtcagac cactacacgg atgcaatgac tcgctttctt gctgtccaat 1620 ttctattaaa ggttcctttg ttccctaagt ccaactacta aactggggga tattatgaag 1680 ggccttgagc atctggattc tgcctaataa aaaacattta ttttcattgc aatgatgtat 1740 ttaaattatt tctgaatatt ttactaaaaa gggaatgtgg gaggtcagtg catttaaaac 1800 ataaagaaaa agaagacac 1819 <210> 301 <211> 2336 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 301 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg acacaagaca 120 ggcttgcgag atatgtttga gaataccact ttatcccgcg tcagggagag gcagtgcgta 180 aaaagacgcg gactcatgtg aaatactggt ttttagtgcg ccagatctct ataatctcgc 240 gcaacctatt ttcccctcga acacttttta agccgtagat aaacaggctg ggacacttca 300 catggccacc tcagcaagtt cccacttgaa caaaaacatc aagcaaatgt acttgtgcct 360 gccccagggt gagaaagtcc aagccatgta tatctgggtt gatggtactg gagaaggact 420 gcgctgcaaa acccgcaccc tggactgtga gcccaagtgt gtagaagagt tacctgagtg 480 gaattttgat ggctctagta cctttcagtc tgagggctcc aacagtgaca tgtatctcag 540 ccctgttgcc atgtttcggg accccttccg cagagatccc aacaagctgg tgttctgtga 600 agttttcaag tacaaccgga agcctgcaga gactaattta aggcactcgt gtaaacggat 660 aatggacatg gtgagcaacc agcacccctg gtttggaatg gaacaggagt atactctgat 720 gggaacagat gggcaccctt ttggttggcc ttccaatggc tttcctgggc cccaaggtcc 780 gtattactgt ggtgtgggcg cagacaaagc ctatggcagg gatatcgtgg aggctcacta 840 ccgcgcctgc ttgtatgctg gggtcaagat tacaggaaca aatgctgagg tcatgcctgc 900 ccagtgggag ttccaaatag gaccctgtga aggaatccgc atgggagatc atctctgggt 960 ggcccgtttc atcttgcatc gagtatgtga ggactttggg gtaatagcaa cctttgaccc 1020 caagcccatt cctgggaact ggaatggtgc aggctgccat accaacttta gcaccaaggc 1080 catgcgggag gagaatggtc tgaagcacat cgaggaggcc atcgagaaac taagcaagcg 1140 gcaccggtac cacattcgag cctacgatcc caaggggggc ctggacaatg cccgtcgtct 1200 gactgggttc cacgaaacgt ccaacatcaa cgacttttct gctggtgtcg ccaatcgcag 1260 tgccagcatc cgcattcccc ggactgtcgg ccaggagaag aaaggttact ttgaagatcg 1320 ccgcccctct gccaattgtg acccctttgc agtgacagaa gccatcgtcc gcacatgcct 1380 tctcaatgag actggcgacg agcccttcca atacaaaaac taataattag actttgagtg 1440 atcttgagcc tttcctagtt catcccaccc cgccccagag agatctttgt gaaggaacct 1500 tacttctgtg gtgtgacata attggacaaa ctacctacag agatttaaag ctctaaggta 1560 aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt ttgtgtattt 1620 tagattccaa cctatggaac tgatgaatgg gagcagtggt ggaatgcctt taatgaggaa 1680 aacctgtttt gctcagaaga aatgccatct agtgatgatg aggctactgc tgactctcaa 1740 cattctactc ctccaaaaaa gaagagaaag gtagaagatc ccaaggactt tccttcagaa 1800 ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa ctcttgcttg ctttgctatt 1860 tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa ttatggaaaa atattctgta 1920 acctttataa gtaggcataa cagttataat cataacatac tgttttttct tactccacac 1980 aggcatagag tgtctgctat taataactat gctcaaaaat tgtgtacctt tagcttttta 2040 atttgtaaag gggttaataa ggaatatttg atgtatagtg ccttgactag agatcataat 2100 cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct 2160 gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa 2220 tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 2280 ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga agacac 2336 <210> 302 <211> 2571 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 302 atgtcttcca ctgacgggca ccggagcctc acgaagtttg aattgcggcg acagatcaag 60 tttcctcttt aattaagctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct 120 ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa 180 agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa 240 ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt 300 ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct 360 ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc 420 tagcttgggg ccaccgctca gagcaccttc caccatggcc acctcagcaa gttcccactt 480 gaacaaaaac atcaagcaaa tgtacttgtg cctgccccag ggtgagaaag tccaagccat 540 gtatatctgg gttgatggta ctggagaagg actgcgctgc aaaacccgca ccctggactg 600 tgagcccaag tgtgtagaag agttacctga gtggaatttt gatggctcta gtacctttca 660 gtctgagggc tccaacagtg acatgtatct cagccctgtt gccatgtttc gggacccctt 720 ccgcagagat cccaacaagc tggtgttctg tgaagttttc aagtacaacc ggaagcctgc 780 agagactaat ttaaggcact cgtgtaaacg gataatggac atggtgagca accagcaccc 840 ctggtttgga atggaacagg agtatactct gatgggaaca gatgggcacc cttttggttg 900 gccttccaat ggctttcctg ggccccaagg tccgtattac tgtggtgtgg gcgcagacaa 960 agcctatggc agggatatcg tggaggctca ctaccgcgcc tgcttgtatg ctggggtcaa 1020 gattacagga acaaatgctg aggtcatgcc tgcccagtgg gagttccaaa taggaccctg 1080 tgaaggaatc cgcatgggag atcatctctg ggtggcccgt ttcatcttgc atcgagtatg 1140 tgaggacttt ggggtaatag caacctttga ccccaagccc attcctggga actggaatgg 1200 tgcaggctgc cataccaact ttagcaccaa ggccatgcgg gaggagaatg gtctgaagca 1260 catcgaggag gccatcgaga aactaagcaa gcggcaccgg taccacattc gagcctacga 1320 tcccaagggg ggcctggaca atgcccgtcg tctgactggg ttccacgaaa cgtccaacat 1380 caacgacttt tctgctggtg tcgccaatcg cagtgccagc atccgcattc cccggactgt 1440 cggccaggag aagaaaggtt actttgaaga tcgccgcccc tctgccaatt gtgacccctt 1500 tgcagtgaca gaagccatcg tccgcacatg ccttctcaat gagactggcg acgagccctt 1560 ccaatacaaa aactaattag actttgagtg atcttgagcc tttcctagtt catcccaccc 1620 cgccccagag agatctttgt gaaggaacct tacttctgtg gtgtgacata attggacaaa 1680 ctacctacag agatttaaag ctctaaggta aatataaaat ttttaagtgt ataatgtgtt 1740 aaactactga ttctaattgt ttgtgtattt tagattccaa cctatggaac tgatgaatgg 1800 gagcagtggt ggaatgcctt taatgaggaa aacctgtttt gctcagaaga aatgccatct 1860 agtgatgatg aggctactgc tgactctcaa cattctactc ctccaaaaaa gaagagaaag 1920 gtagaagatc ccaaggactt tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt 1980 agtaatagaa ctcttgcttg ctttgctatt tacaccacaa aggaaaaagc tgcactgcta 2040 tacaagaaaa ttatggaaaa atattctgta acctttataa gtaggcataa cagttataat 2100 cataacatac tgttttttct tactccacac aggcatagag tgtctgctat taataactat 2160 gctcaaaaat tgtgtacctt tagcttttta atttgtaaag gggttaataa ggaatatttg 2220 atgtatagtg ccttgactag agatcataat cagccatacc acatttgtag aggttttact 2280 tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt 2340 tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 2400 tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa 2460 tgtatcttat catgtctgga tctagcttcg tgtcaaggac ggtgactgca gtgaataata 2520 aaatgtgtgt ttgtccgaaa tacgcgtttt gagatttctc gaggaagaca t 2571 <210> 303 <211> 2571 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 303 atgtcttcct cgagaaatct caaaacgcgt atttcggaca aacacacatt ttattattca 60 ctgcagtcac cgtccttgac acgaagctag atccagacat gataagatac attgatgagt 120 ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg 180 ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca 240 ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc 300 tctacaaatg tggtatggct gattatgatc tctagtcaag gcactataca tcaaatattc 360 cttattaacc cctttacaaa ttaaaaagct aaaggtacac aatttttgag catagttatt 420 aatagcagac actctatgcc tgtgtggagt aagaaaaaac agtatgttat gattataact 480 gttatgccta cttataaagg ttacagaata tttttccata attttcttgt atagcagtgc 540 agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga gttctattac taaacacagc 600 atgactcaaa aaacttagca attctgaagg aaagtccttg ggatcttcta cctttctctt 660 cttttttgga ggagtagaat gttgagagtc agcagtagcc tcatcatcac tagatggcat 720 ttcttctgag caaaacaggt tttcctcatt aaaggcattc caccactgct cccattcatc 780 agttccatag gttggaatct aaaatacaca aacaattaga atcagtagtt taacacatta 840 tacacttaaa aattttatat ttaccttaga gctttaaatc tctgtaggta gtttgtccaa 900 ttatgtcaca ccacagaagt aaggttcctt cacaaagatc tctctggggc ggggtgggat 960 gaactaggaa aggctcaaga tcactcaaag tctaattagt ttttgtattg gaagggctcg 1020 tcgccagtct cattgagaag gcatgtgcgg acgatggctt ctgtcactgc aaaggggtca 1080 caattggcag aggggcggcg atcttcaaag taacctttct tctcctggcc gacagtccgg 1140 ggaatgcgga tgctggcact gcgattggcg acaccagcag aaaagtcgtt gatgttggac 1200 gtttcgtgga acccagtcag acgacgggca ttgtccaggc cccccttggg atcgtaggct 1260 cgaatgtggt accggtgccg cttgcttagt ttctcgatgg cctcctcgat gtgcttcaga 1320 ccattctcct cccgcatggc cttggtgcta aagttggtat ggcagcctgc accattccag 1380 ttcccaggaa tgggcttggg gtcaaaggtt gctattaccc caaagtcctc acatactcga 1440 tgcaagatga aacgggccac ccagagatga tctcccatgc ggattccttc acagggtcct 1500 atttggaact cccactgggc aggcatgacc tcagcatttg ttcctgtaat cttgacccca 1560 gcatacaagc aggcgcggta gtgagcctcc acgatatccc tgccataggc tttgtctgcg 1620 cccacaccac agtaatacgg accttggggc ccaggaaagc cattggaagg ccaaccaaaa 1680 gggtgcccat ctgttcccat cagagtatac tcctgttcca ttccaaacca ggggtgctgg 1740 ttgctcacca tgtccattat ccgtttacac gagtgcctta aattagtctc tgcaggcttc 1800 cggttgtact tgaaaacttc acagaacacc agcttgttgg gatctctgcg gaaggggtcc 1860 cgaaacatgg caacagggct gagatacatg tcactgttgg agccctcaga ctgaaaggta 1920 ctagagccat caaaattcca ctcaggtaac tcttctacac acttgggctc acagtccagg 1980 gtgcgggttt tgcagcgcag tccttctcca gtaccatcaa cccagatata catggcttgg 2040 actttctcac cctggggcag gcacaagtac atttgcttga tgtttttgtt caagtgggaa 2100 cttgctgagg tggccatggt ggaaggtgct ctgagcggtg gccccaagct agctttttgc 2160 aaaagcctag gcctccaaaa aagcctcctc actacttctg gaatagctca gaggccgagg 2220 cggcctcggc ctctgcataa ataaaaaaaa ttagtcagcc atggggcgga gaatgggcgg 2280 aactgggcgg agttaggggc gggatgggcg gagttagggg cgggactatg gttgctgact 2340 aattgagatg catgctttgc atacttctgc ctgctgggga gcctggggac tttccacacc 2400 tggttgctga ctaattgaga tgcatgcttt gcatacttct gcctgctggg gagcctgggg 2460 actttccaca ccctaactga cacacattcc acagcttaat taaagaggaa acttgatctg 2520 tcgccgcaat tcaaacttcg tgaggctccg gtgcccgtca gtggaagaca t 2571 <210> 304 <211> 1765 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 304 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 cccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag gtatgtcatg 1500 gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag cctgtaaaag 1560 actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg tgtcctgagt 1620 gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa agttttgctg 1680 cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg aagtctaaca 1740 atctctcggg gggatccgaa gacac 1765 <210> 305 <211> 1659 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 305 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 cctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac 1500 taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt 1560 tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa aagggaatgt 1620 gggaggtcag tgcatttaaa acataaagaa agaagacac 1659 <210> 306 <211> 1765 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 306 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggcatcaa gcaaatgtac atgtccctgc cccagggtga 300 gaaaatccaa gccatgtata tctgggttga tggtaccgga gaaggactgc gctgcaagac 360 ccgtaccctg gactgtgacc ccaagtgtgt ggaagagtta cctgagtgga actttgatgg 420 ctctagtacc tttcagtctg aaggctccaa cagcgacatg tacctccatc ctgttgccat 480 gtttcgggac cccttccgca aagaccccaa caagctggtg ctatgtgaag ttttcaagta 540 taaccggaag cctgcagaaa ccaacttgag gcacatctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga gcaggaatat actcttatgg gaacagacgg 660 ccacccattt ggttggcctt ccaatggctt ccctggaccc caaggcccgt attactgcgg 720 tgtgggagca gacaaggcct acggcaggga catcgtggag gctcactacc gggcctgctt 780 gtatgctgga gtcaagatca cggggacaaa tgcggaggtt atgcctgccc agtgggaatt 840 ccagatagga ccctgtgagg gaatccgaat gggagatcat ctttggatag cccgttttat 900 cttgcatcgg gtgtgcgaag attttggggt gatagcaacc tttgacccca agcccattcc 960 agggaactgg aatggtgcag gctgccatac caacttcagc accaaggcca tgcgggagga 1020 gaatggtctg aagtgcattg aggaggccat tgacaaactg agcaagaggc accagtacca 1080 catccgcgcc tacgatccca aggggggcct ggacaacgcc cggcgtctga ctggattcca 1140 cgaaacctcc aacatcaacg acttttctgc cggtgttgcc aaccgctccg ccagtatccg 1200 cattccccgg actgtcggcc aggagaagaa gggctacttt gaggaccgtc ggccttctgc 1260 caattgtgac ccctatgcgg tgacagaagc catcgtccgc acgtgtctcc tcaacgaaac 1320 aggcgacgaa cccttccaat acaagaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 cccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag gtatgtcatg 1500 gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag cctgtaaaag 1560 actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg tgtcctgagt 1620 gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa agttttgctg 1680 cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg aagtctaaca 1740 atctctcggg gggatccgaa gacac 1765 <210> 307 <211> 1765 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 307 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 cccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag gtatgtcatg 1500 gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag cctgtaaaag 1560 actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg tgtcctgagt 1620 gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa agttttgctg 1680 cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg aagtctaaca 1740 atctctcggg gggatccgaa gacac 1765 <210> 308 <211> 1659 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 308 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 cctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac 1500 taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt 1560 tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa aagggaatgt 1620 gggaggtcag tgcatttaaa acataaagaa agaagacac 1659 <210> 309 <211> 1591 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 309 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta atggatccgc tcagacatga taagatacat 1380 tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat 1440 ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa 1500 caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa 1560 gtaaaacctc tacaaatgtg gtagaagaca c 1591 <210> 310 <211> 1591 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 310 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggcatcaa gcaaatgtac atgtccctgc cccagggtga 300 gaaaatccaa gccatgtata tctgggttga tggtaccgga gaaggactgc gctgcaagac 360 ccgtaccctg gactgtgacc ccaagtgtgt ggaagagtta cctgagtgga actttgatgg 420 ctctagtacc tttcagtctg aaggctccaa cagcgacatg tacctccatc ctgttgccat 480 gtttcgggac cccttccgca aagaccccaa caagctggtg ctatgtgaag ttttcaagta 540 taaccggaag cctgcagaaa ccaacttgag gcacatctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga gcaggaatat actcttatgg gaacagacgg 660 ccacccattt ggttggcctt ccaatggctt ccctggaccc caaggcccgt attactgcgg 720 tgtgggagca gacaaggcct acggcaggga catcgtggag gctcactacc gggcctgctt 780 gtatgctgga gtcaagatca cggggacaaa tgcggaggtt atgcctgccc agtgggaatt 840 ccagatagga ccctgtgagg gaatccgaat gggagatcat ctttggatag cccgttttat 900 cttgcatcgg gtgtgcgaag attttggggt gatagcaacc tttgacccca agcccattcc 960 agggaactgg aatggtgcag gctgccatac caacttcagc accaaggcca tgcgggagga 1020 gaatggtctg aagtgcattg aggaggccat tgacaaactg agcaagaggc accagtacca 1080 catccgcgcc tacgatccca aggggggcct ggacaacgcc cggcgtctga ctggattcca 1140 cgaaacctcc aacatcaacg acttttctgc cggtgttgcc aaccgctccg ccagtatccg 1200 cattccccgg actgtcggcc aggagaagaa gggctacttt gaggaccgtc ggccttctgc 1260 caattgtgac ccctatgcgg tgacagaagc catcgtccgc acgtgtctcc tcaacgaaac 1320 aggcgacgaa cccttccaat acaagaacta atggatccgc tcagacatga taagatacat 1380 tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat 1440 ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa 1500 caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa 1560 gtaaaacctc tacaaatgtg gtagaagaca c 1591 <210> 311 <211> 1591 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 311 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta atggatccgc tcagacatga taagatacat 1380 tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat 1440 ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa 1500 caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa 1560 gtaaaacctc tacaaatgtg gtagaagaca c 1591 <210> 312 <211> 1778 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 312 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 ttagtttttg tattggaagg gctcgtcgcc agtctcattg agaaggcatg tgcggacgat 300 ggcttctgtc actgcaaagg ggtcacaatt ggcagagggg cggcgatctt caaagtaacc 360 tttcttctcc tggccgacag tccggggaat gcggatgctg gcactgcgat tggcgacacc 420 agcagaaaag tcgttgatgt tggacgtttc gtggaaccca gtcagacgac gggcattgtc 480 caggcccccc ttgggatcgt aggctcgaat gtggtacctg tgccgcttgc ttagtttctc 540 gatggcctcc tcgatgtgct tcagaccatt ctcctcccgc atggccttgg tgctaaagtt 600 ggtatggcag cctgcaccat tccagttccc aggaatgggc ttggggtcaa aggttgctat 660 taccccaaag tcctcacata ctcgatgcaa gatgaaacgg gccacccaga gatgatctcc 720 catgcggatt ccttcacagg gtcctatttg gaactcccac tgggcaggca tgacctcagc 780 atttgttcct gtaatcttga ccccagcata caagcaggcg cggtagtgag cctccacgat 840 atccctgcca taggctttgt ctgcgcccac accacagtaa tacggacctt ggggcccagg 900 aaagccattg gaaggccaac caaaagggtg cccatctgtt cccatcagag tatactcctg 960 ttccattcca aaccaggggt gctggttgct caccatgtcc attatccgtt tacacgagtg 1020 ccttaaattt gtctctgcag gcttccggtt gtacttgaaa acttcacaga acaccagctt 1080 gttgggatct ctgcggaagg ggtcccgaaa catggcaaca gggctgagat acatgtcact 1140 gttggagccc tcagactgaa aggtactaga gccatcaaaa ttccactcag gtaactcttc 1200 tacacacttg ggctcacagt ccagggtgcg ggttttgcag cgcagtcctt ctccagtacc 1260 atcaacccag atatacatgg cttggacttt ctcaccctgg ggcaggcaca agtacatttg 1320 cttgatgttt ttgttcaagt gggaacttgc tgaggtggcc atgtgaagtg tcccagcctg 1380 tttatctacg gcttaaaaag tgttcgaggg gaaaataggt tgcgcgagat tatagagatc 1440 tggcgcacta aaaaccagta tttcacatga gtccgcgtct ttttacgcac tgcctctccc 1500 tgacgcggga taaagtggta ttctcaaaca tatctcgcaa gcctgtcttg tgtccctgca 1560 gagtcgctct gtgttcgagg ccacacgcgt caccttaata tgcgaagtgg acctgggacc 1620 gcgccgcccc gactgcatct gcgtgttttc gccaatgaca agacgctggg cggggtttgt 1680 gtcatcatag aactaaagac atgcaaatat atttcttccg gggacaccgc cagcaaacgc 1740 gagcaacggg ccacggggat gaagcagctg gaagacta 1778 <210> 313 <211> 1721 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 313 ttgtcttcgg cgcgcccagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 gccacctcag caagttccca cttgaacaaa aacatcaagc aaatgtactt gtgcctgccc 300 cagggtgaga aagtccaagc catgtatatc tgggttgatg gtactggaga aggactgcgc 360 tgcaaaaccc gcaccctgga ctgtgagccc aagtgtgtag aagagttacc tgagtggaat 420 tttgatggct ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctcagccct 480 gttgccatgt ttcgggaccc cttccgcaga gatcccaaca agctggtgtt ctgtgaagtt 540 ttcaagtaca accggaagcc tgcagagaca aatttaaggc actcgtgtaa acggataatg 600 gacatggtga gcaaccagca cccctggttt ggaatggaac aggagtatac tctgatggga 660 acagatgggc acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat 720 tactgtggtg tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc 780 gcctgcttgt atgctggggt caagattaca ggaacaaatg ctgaggtcat gcctgcccag 840 tgggagttcc aaataggacc ctgtgaagga atccgcatgg gagatcatct ctgggtggcc 900 cgtttcatct tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag 960 cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg 1020 cgggaggaga atggtctgaa gcacatcgag gaggccatcg agaaactaag caagcggcac 1080 aggtaccaca ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact 1140 gggttccacg aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc 1200 agcatccgca ttccccggac tgtcggccag gagaagaaag gttactttga agatcgccgc 1260 ccctctgcca attgtgaccc ctttgcagtg acagaagcca tcgtccgcac atgccttctc 1320 aatgagactg gcgacgagcc cttccaatac aaaaactgga tccgctcaga catgataaga 1380 tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt 1440 gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 1500 aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 1560 agcaagtaaa acctctacaa atgtggtaaa atcgataata tatggtaggg ttcatagcca 1620 gagtaacctt tttttttaat ttttatttta ttttattttt gagtcgggcg cgcaaaaatg 1680 aagtgaagtt cctatacttt ctagattaat taagaagact t 1721 <210> 314 <211> 2261 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 314 ttgtcttcgg cgcgcctacc acatttgtaa ggttttactt gctttaaaaa acctcccaca 60 cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc 120 agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 180 ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctgagc 240 ggatccagtt tttgtattgg aagggctcgt cgccagtctc attgagaagg catgtgcgga 300 cgatggcttc tgtcactgca aaggggtcac aattggcaga ggggcggcga tcttcaaagt 360 aacctttctt ctcctggccg acagtccggg gaatgcggat gctggcactg cgattggcga 420 caccagcaga aaagtcgttg atgttggacg tttcgtggaa cccagtcaga cgacgggcat 480 tgtccaggcc ccccttggga tcgtaggctc gaatgtggta cctgtgccgc ttgcttagtt 540 tctcgatggc ctcctcgatg tgcttcagac cattctcctc ccgcatggcc ttggtgctaa 600 agttggtatg gcagcctgca ccattccagt tcccaggaat gggcttgggg tcaaaggttg 660 ctattacccc aaagtcctca catactcgat gcaagatgaa acgggccacc cagagatgat 720 ctcccatgcg gattccttca cagggtccta tttggaactc ccactgggca ggcatgacct 780 cagcatttgt tcctgtaatc ttgaccccag catacaagca ggcgcggtag tgagcctcca 840 cgatatccct gccataggct ttgtctgcgc ccacaccaca gtaatacgga ccttggggcc 900 caggaaagcc attggaaggc caaccaaaag ggtgcccatc tgttcccatc agagtatact 960 cctgttccat tccaaaccag gggtgctggt tgctcaccat gtccattatc cgtttacacg 1020 agtgccttaa atttgtctct gcaggcttcc ggttgtactt gaaaacttca cagaacacca 1080 gcttgttggg atctctgcgg aaggggtccc gaaacatggc aacagggctg agatacatgt 1140 cactgttgga gccctcagac tgaaaggtac tagagccatc aaaattccac tcaggtaact 1200 cttctacaca cttgggctca cagtccaggg tgcgggtttt gcagcgcagt ccttctccag 1260 taccatcaac ccagatatac atggcttgga ctttctcacc ctggggcagg cacaagtaca 1320 tttgcttgat gtttttgttc aagtgggaac ttgctgaggt ggccatgcca ccctgcagag 1380 tcgctctgtg ttcgaggcca cacgcgtcac cttaatatgc gaagtggacc tgggaccgcg 1440 ccgccccgac tgcatctgcg tgttttcgcc aatgacaaga cgctgggcgg ggtttgtgtc 1500 atcatagaac taaagacatg caaatatatt tcttccgggg acaccgccag caaacgcgag 1560 caacgggcca cggggatgaa gcagctgtag actctgggta gaatgttctg tttcctgtaa 1620 tataaaatca taaagtgatg atattatcaa gtgaaaagga aatgtggtac cttaatcttt 1680 ccacatcaag ccaatatcat gctgaaggcc agagaatctt ttttgctaaa aaacacaata 1740 cagatataat taatagttat catttatgtt tgatattaat catatgaata taattaatat 1800 gttttattgt atcgattatt gttgatatta atgtaattac tactaataca taacaaatat 1860 aactaatggt tatggctcag taactaaggt aagatataag ctacactggt aaagaaagat 1920 caatattgct tcagagtaca ctgaagtaaa tgaataactt aaccggtcta ggttgtcact 1980 tatatttata cgaaacttga tctgtcgccg caattcaagc ttcgtgaggc tccggtgccc 2040 gtcagtgacc tgctatagaa acttgatctg tcgccgcaat tcaagcttcg tgaggctccg 2100 gtgcccgtca gtgacctgct atactctgaa atcgataata tatggtaggg ttcatagcca 2160 gagtaacctt tttttttaat ttttatttta ttttattttt gagtcgggcg cgcaaaaatg 2220 aagtgaagtt cctatacttt ctagattaat taagaagact t 2261 <210> 315 <211> 2192 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 315 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgccaccat ggttgagaat accactttat cccgcgtcag ggagaggcag tgcgtaaaaa 300 gacgcggaac catgtgaaat actggttttt agtgcgccag atctctataa tctcgcgcaa 360 cctattttcc cctcgaacac tttttaagcc gtagataaac aggctgggac acttcacatg 420 gccacctcag caagttccca cttgaacaaa aacatcaagc aaatgtacct gtgcctgccc 480 cagggtgaga aagtccaagc catgtatatc tgggttgatg gtactggaga aggactgcgc 540 tgcaaaaccc gcaccctgga ctgtgagccc aagtgtgtag aagagttacc tgagtggaat 600 tttgatggct ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctcagccct 660 gttgccatgt ttcgggaccc cttccgccgg gagcccaaca agctggtgtt ctgtgaagtt 720 ttcaagtaca accggaagcc tgcagagaca aatttaaggc actcctgtaa acggataatg 780 gacatggtga gcaaccagca cccctggttt ggaatggaac aggagtatac tctgatggga 840 acagatgggc acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat 900 tactgtggtg tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc 960 gcctgcttgt atgctggggt caagattaca ggaacaaatg ctgaggtcat gcctgcccag 1020 tgggagttcc aaataggacc ctgtgaagga atccacatgg gagatcatct ctgggtggcc 1080 cgtttcatct tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag 1140 cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg 1200 cgggaggaga atggtctgaa gcacatcgag gaggccatcg agaaactaag caagcggcac 1260 cagtaccaca ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact 1320 gggttccacg aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc 1380 agcatccgca ttccccggac tgtcggccag gagaagaaag gttactttga agatcgccgc 1440 ccctctgcca attgtgaccc ctttgcagtg acagaagcca tcgtccgcac atgccttctc 1500 aatgagactg gcgacgagcc cttccaatac aaaaactaat aattagactt tgagtgatct 1560 tgagcctttc ctagttcatc ccaccccgcc ccagagagat ctttgtgaag gaaccttact 1620 tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata 1680 taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga 1740 ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc 1800 tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt 1860 ctactcctcc acagacctgg tgaccgtcag gaagaagatt cagtgagagg acacgaggta 1920 tgtcatggtt tttaatcaat aaataaagag gttttattca tcggacagtc gttgtagcct 1980 gtaaaagact cgccccggag ggggttcccc cgatgtgagg ggcatgcagt agtatggtgt 2040 cctgagtgtc tcggatgcgt ccttgaactc gcactctacc gccgtggggg ttaataaagt 2100 tttgctgcgc cggtaggggg ggaggccgag gataataaag ttgctacgta ctggttgaag 2160 tctaacaatc tctcgggggg atccgaagac ac 2192 <210> 316 <211> 2255 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 316 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgccaccat ggttgagaat accactttat cccgcgtcag ggagaggcag tgcgtaaaaa 300 gacgcggaac catgtgaaat actggttttt agtgcgccag atctctataa tctcgcgcaa 360 cctattttcc cctcgaacac tttttaagcc gtagataaac aggctgggac acttcacatg 420 gccacctcag caagttccca cttgaacaaa aacatcaagc aaatgtacct gtgcctgccc 480 cagggtgaga aagtccaagc catgtatatc tgggttgatg gtactggaga aggactgcgc 540 tgcaaaaccc gcaccctgga ctgtgagccc aagtgtgtag aagagttacc tgagtggaat 600 tttgatggct ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctcagccct 660 gttgccatgt ttcgggaccc cttccgccgg gagcccaaca agctggtgtt ctgtgaagtt 720 ttcaagtaca accggaagcc tgcagagaca aatttaaggc actcctgtaa acggataatg 780 gacatggtga gcaaccagca cccctggttt ggaatggaac aggagtatac tctgatggga 840 acagatgggc acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat 900 tactgtggtg tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc 960 gcctgcttgt atgctggggt caagattaca ggaacaaatg ctgaggtcat gcctgcccag 1020 tgggagttcc aaataggacc ctgtgaagga atccacatgg gagatcatct ctgggtggcc 1080 cgtttcatct tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag 1140 cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg 1200 cgggaggaga atggtctgaa gcacatcgag gaggccatcg agaaactaag caagcggcac 1260 cagtaccaca ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact 1320 gggttccacg aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc 1380 agcatccgca ttccccggac tgtcggccag gagaagaaag gttactttga agatcgccgc 1440 ccctctgcca attgtgaccc ctttgcagtg acagaagcca tcgtccgcac atgccttctc 1500 aatgagactg gcgacgagcc cttccaatac aaaaactgga tccgctcaga catgataaga 1560 tacattgatg agtttggaca aaccacaact agaatgcagt gataattaga ctttgagtga 1620 tcttgagcct ttcctagttc atcccacccc gccccagaga gatctttgtg aaggaacctt 1680 acttctgtgg tgtgacataa ttggacaaac tacctacaga gatttaaagc tctaaggtaa 1740 atataaaatt tttaagtgta taatgtgtta aactactgat tctaattgtt tgtgtatttt 1800 agattccaac ctatggaact gatgaatggg agcagtggtg gaatgccttt aatgaggaaa 1860 acctgttttg ctcagaagaa atgccatcta gtgatgatga ggctactgct gactctcaac 1920 attctactcc tccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag 1980 gtatgtcatg gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag 2040 cctgtaaaag actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg 2100 tgtcctgagt gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa 2160 agttttgctg cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg 2220 aagtctaaca atctctcggg gggatccgaa gacac 2255 <210> 317 <211> 2192 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 317 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgccaccat ggttgagaat accactttat cccgcgtcag ggagaggcag tgcgtaaaaa 300 gacgcggaac catgtgaaat actggttttt agtgcgccag atctctataa tctcgcgcaa 360 cctattttcc cctcgaacac tttttaagcc gtagataaac aggctgggac acttcacatg 420 gccacctcag caagttccca cttgaacaaa ggaatcaagc aaatgtacat gaacctgccc 480 cagggtgaga aaatccaact gatgtatatc tgggttgatg gtactggaga aggactgcgc 540 tgcaaaaccc gcaccctgga ctgtgacccc aagtgtgtag aagagttacc tgagtggaat 600 tttgatggct ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctccaccct 660 gttgccatgt ttcgggaccc cttccgcaga gatcccaaca agctggtgtt ctgtgaagtt 720 ttcaagtaca accggaagcc tgcagagaca aatttaaggc actcgtgtaa acggataatg 780 gacatggtga gctcccagca cccctggttt ggaatggaac aggagtatac tctgatggga 840 acagatgggc acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat 900 tactgtggtg tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc 960 gcctgcttgt atgctgggat caagattaca ggaacaaatg ctgaggtcat gcctgcccag 1020 tgggagttcc aaataggacc ctgtgaagga atccgcatgg gagatcatct ctgggtggcc 1080 cgtttcatct tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag 1140 cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg 1200 cgggaggaga atggtctgcg gtgcatcgag gaggccatcg acaaactaag caagcggcac 1260 cagtaccaca ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact 1320 gggttccacg aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc 1380 agcatccgca ttccccggat cgtcggccag gagaagaaag gttactttga agatcgccgc 1440 ccctctgcca attgtgaccc ctacgcagtg acagaagcca tcgtccgcac atgccttctc 1500 aatgagactg gcgacgagcc cttccaatac aaaaactaat aattagactt tgagtgatct 1560 tgagcctttc ctagttcatc ccaccccgcc ccagagagat ctttgtgaag gaaccttact 1620 tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata 1680 taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga 1740 ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc 1800 tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt 1860 ctactcctcc acagacctgg tgaccgtcag gaagaagatt cagtgagagg acacgaggta 1920 tgtcatggtt tttaatcaat aaataaagag gttttattca tcggacagtc gttgtagcct 1980 gtaaaagact cgccccggag ggggttcccc cgatgtgagg ggcatgcagt agtatggtgt 2040 cctgagtgtc tcggatgcgt ccttgaactc gcactctacc gccgtggggg ttaataaagt 2100 tttgctgcgc cggtaggggg ggaggccgag gataataaag ttgctacgta ctggttgaag 2160 tctaacaatc tctcgggggg atccgaagac ac 2192 <210> 318 <211> 2255 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 318 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgccaccat ggttgagaat accactttat cccgcgtcag ggagaggcag tgcgtaaaaa 300 gacgcggaac catgtgaaat actggttttt agtgcgccag atctctataa tctcgcgcaa 360 cctattttcc cctcgaacac tttttaagcc gtagataaac aggctgggac acttcacatg 420 gccacctcag caagttccca cttgaacaaa ggaatcaagc aaatgtacat gaacctgccc 480 cagggtgaga aaatccaact gatgtatatc tgggttgatg gtactggaga aggactgcgc 540 tgcaaaaccc gcaccctgga ctgtgacccc aagtgtgtag aagagttacc tgagtggaat 600 tttgatggct ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctccaccct 660 gttgccatgt ttcgggaccc cttccgcaga gatcccaaca agctggtgtt ctgtgaagtt 720 ttcaagtaca accggaagcc tgcagagaca aatttaaggc actcgtgtaa acggataatg 780 gacatggtga gctcccagca cccctggttt ggaatggaac aggagtatac tctgatggga 840 acagatgggc acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat 900 tactgtggtg tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc 960 gcctgcttgt atgctgggat caagattaca ggaacaaatg ctgaggtcat gcctgcccag 1020 tgggagttcc aaataggacc ctgtgaagga atccgcatgg gagatcatct ctgggtggcc 1080 cgtttcatct tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag 1140 cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg 1200 cgggaggaga atggtctgcg gtgcatcgag gaggccatcg acaaactaag caagcggcac 1260 cagtaccaca ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact 1320 gggttccacg aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc 1380 agcatccgca ttccccggat cgtcggccag gagaagaaag gttactttga agatcgccgc 1440 ccctctgcca attgtgaccc ctacgcagtg acagaagcca tcgtccgcac atgccttctc 1500 aatgagactg gcgacgagcc cttccaatac aaaaactgga tccgctcaga catgataaga 1560 tacattgatg agtttggaca aaccacaact agaatgcagt gataattaga ctttgagtga 1620 tcttgagcct ttcctagttc atcccacccc gccccagaga gatctttgtg aaggaacctt 1680 acttctgtgg tgtgacataa ttggacaaac tacctacaga gatttaaagc tctaaggtaa 1740 atataaaatt tttaagtgta taatgtgtta aactactgat tctaattgtt tgtgtatttt 1800 agattccaac ctatggaact gatgaatggg agcagtggtg gaatgccttt aatgaggaaa 1860 acctgttttg ctcagaagaa atgccatcta gtgatgatga ggctactgct gactctcaac 1920 attctactcc tccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag 1980 gtatgtcatg gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag 2040 cctgtaaaag actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg 2100 tgtcctgagt gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa 2160 agttttgctg cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg 2220 aagtctaaca atctctcggg gggatccgaa gacac 2255 <210> 319 <211> 1591 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 319 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 ttagtttttg tattggaagg gctcgtcgcc agtctcattg agaaggcatg tgcggacgat 300 ggcttctgtc actgcaaagg ggtcacaatt ggcagagggg cggcgatctt caaagtaacc 360 tttcttctcc tggccgacag tccggggaat gcggatgctg gcactgcgat tggcgacacc 420 agcagaaaag tcgttgatgt tggacgtttc gtggaaccca gtcagacgac gggcattgtc 480 caggcccccc ttgggatcgt aggctcgaat gtggtacctg tgccgcttgc ttagtttctc 540 gatggcctcc tcgatgtgct tcagaccatt ctcctcccgc atggccttgg tgctaaagtt 600 ggtatggcag cctgcaccat tccagttccc aggaatgggc ttggggtcaa aggttgctat 660 taccccaaag tcctcacata ctcgatgcaa gatgaaacgg gccacccaga gatgatctcc 720 catgcggatt ccttcacagg gtcctatttg gaactcccac tgggcaggca tgacctcagc 780 atttgttcct gtaatcttga ccccagcata caagcaggcg cggtagtgag cctccacgat 840 atccctgcca taggctttgt ctgcgcccac accacagtaa tacggacctt ggggcccagg 900 aaagccattg gaaggccaac caaaagggtg cccatctgtt cccatcagag tatactcctg 960 ttccattcca aaccaggggt gctggttgct caccatgtcc attatccgtt tacacgagtg 1020 ccttaaattt gtctctgcag gcttccggtt gtacttgaaa acttcacaga acaccagctt 1080 gttgggatct ctgcggaagg ggtcccgaaa catggcaaca gggctgagat acatgtcact 1140 gttggagccc tcagactgaa aggtactaga gccatcaaaa ttccactcag gtaactcttc 1200 tacacacttg ggctcacagt ccagggtgcg ggttttgcag cgcagtcctt ctccagtacc 1260 atcaacccag atatacatgg cttggacttt ctcaccctgg ggcaggcaca agtacatttg 1320 cttgatgttt ttgttcaagt gggaacttgc tgaggtggcc atgccaccct gcagagtcgc 1380 tctgtgttcg aggccacacg cgtcacctta atatgcgaag tggacctggg accgcgccgc 1440 cccgactgca tctgcgtgtt ttcgccaatg acaagacgct gggcggggtt tgtgtcatca 1500 tagaactaaa gacatgcaaa tatatttctt ccggggacac cgccagcaaa cgcgagcaac 1560 gggccacggg gatgaagcag ctggaagact a 1591 <210> 320 <211> 2264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 320 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta ataattagac tttgagtgat cttgagcctt 1380 tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt 1440 gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt 1500 ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc 1560 tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc 1620 tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct 1680 ccaaaaaaga agagaaaggt agaagatccc aaggactttc cttcagaatt gctaagtttt 1740 ttgagtcatg ctgtgtttag taatagaact cttgcttgct ttgctattta caccacaaag 1800 gaaaaagctg cactgctata caagaaaatt atggaaaaat attctgtaac ctttataagt 1860 aggcataaca gttataatca taacatactg ttttttctta ctccacacag gcatagagtg 1920 tctgctatta ataactatgc tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg 1980 gttaataagg aatatttgat gtatagtgcc ttgactagag atcataatca gccataccac 2040 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 2100 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 2160 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 2220 tttgtccaaa ctcatcaatg tatcttatca tgtctggaag acac 2264 <210> 321 <211> 2264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 321 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ttgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc acaggtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtggactga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta ataattagac tttgagtgat cttgagcctt 1380 tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt 1440 gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt 1500 ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc 1560 tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc 1620 tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct 1680 ccaaaaaaga agagaaaggt agaagatccc aaggactttc cttcagaatt gctaagtttt 1740 ttgagtcatg ctgtgtttag taatagaact cttgcttgct ttgctattta caccacaaag 1800 gaaaaagctg cactgctata caagaaaatt atggaaaaat attctgtaac ctttataagt 1860 aggcataaca gttataatca taacatactg ttttttctta ctccacacag gcatagagtg 1920 tctgctatta ataactatgc tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg 1980 gttaataagg aatatttgat gtatagtgcc ttgactagag atcataatca gccataccac 2040 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 2100 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 2160 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 2220 tttgtccaaa ctcatcaatg tatcttatca tgtctggaag acac 2264 <210> 322 <211> 2264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 322 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta ataattagac tttgagtgat cttgagcctt 1380 tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt 1440 gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt 1500 ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc 1560 tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc 1620 tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct 1680 ccaaaaaaga agagaaaggt agaagatccc aaggactttc cttcagaatt gctaagtttt 1740 ttgagtcatg ctgtgtttag taatagaact cttgcttgct ttgctattta caccacaaag 1800 gaaaaagctg cactgctata caagaaaatt atggaaaaat attctgtaac ctttataagt 1860 aggcataaca gttataatca taacatactg ttttttctta ctccacacag gcatagagtg 1920 tctgctatta ataactatgc tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg 1980 gttaataagg aatatttgat gtatagtgcc ttgactagag atcataatca gccataccac 2040 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 2100 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 2160 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 2220 tttgtccaaa ctcatcaatg tatcttatca tgtctggaag acac 2264 <210> 323 <211> 2264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 323 gtgtcttcca gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca 60 gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat 120 aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg 180 ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta tggctgatta 240 tgatctctag tcaaggcact atacatcaaa tattccttat taaccccttt acaaattaaa 300 aagctaaagg tacacaattt ttgagcatag ttattaatag cagacactct atgcctgtgt 360 ggagtaagaa aaaacagtat gttatgatta taactgttat gcctacttat aaaggttaca 420 gaatattttt ccataatttt cttgtatagc agtgcagctt tttcctttgt ggtgtaaata 480 gcaaagcaag caagagttct attactaaac acagcatgac tcaaaaaact tagcaattct 540 gaaggaaagt ccttgggatc ttctaccttt ctcttctttt ttggaggagt agaatgttga 600 gagtcagcag tagcctcatc atcactagat ggcatttctt ctgagcaaaa caggttttcc 660 tcattaaagg cattccacca ctgctcccat tcatcagttc cataggttgg aatctaaaat 720 acacaaacaa ttagaatcag tagtttaaca cattatacac ttaaaaattt tatatttacc 780 ttagagcttt aaatctctgt aggtagtttg tccaattatg tcacaccaca gaagtaaggt 840 tccttcacaa agatctctct ggggcggggt gggatgaact aggaaaggct caagatcact 900 caaagtctaa ttattagttt ttgtattgga agggctcgtc gccagtctca ttgagaaggc 960 atgtgcggac gatggcttct gtcactgcaa aggggtcaca attggcagag gggcggcgat 1020 cttcaaagta acctttcttc tcctggccga cagtccgggg aatgcggatg ctggcactgc 1080 gattggcgac accagcagaa aagtcgttga tgttggacgt ttcgtggaac ccagtcagac 1140 gacgggcatt gtccaggccc cccttgggat cgtaggctcg aatgtggtac ctgtgccgct 1200 tgcttagttt ctcgatggcc tcctcgatgt gcttcagacc attctcctcc cgcatggcct 1260 tggtgctaaa gttggtatgg cagcctgcac cattccagtt cccaggaatg ggcttggggt 1320 caaaggttgc tattacccca aagtcctcac atactcgatg caagatgaaa cgggccaccc 1380 agagatgatc tcccatgcgg attccttcac agggtcctat ttggaactcc cactgggcag 1440 gcatgacctc agcatttgtt cctgtaatct tgaccccagc atacaagcag gcgcggtagt 1500 gagcctccac gatatccctg ccataggctt tgtctgcgcc cacaccacag taatacggac 1560 cttggggccc aggaaagcca ttggaaggcc aaccaaaagg gtgcccatct gttcccatca 1620 gagtatactc ctgttccatt ccaaaccagg ggtgctggtt gctcaccatg tccattatcc 1680 gtttacacga gtgccttaaa tttgtctctg caggcttccg gttgtacttg aaaacttcac 1740 agaacaccag cttgttggga tctctgcgga aggggtcccg aaacatggca acagggctga 1800 gatacatgtc actgttggag ccctcagact gaaaggtact agagccatca aaattccact 1860 caggtaactc ttctacacac ttgggctcac agtccagggt gcgggttttg cagcgcagtc 1920 cttctccagt accatcaacc cagatataca tggcttggac tttctcaccc tggggcaggc 1980 acaagtacat ttgcttgatg tttttgttca agtgggaact tgctgaggtg gccatgccac 2040 cctgcagagt cgctctgtgt tcgaggccac acgcgtcacc ttaatatgcg aagtggacct 2100 gggaccgcgc cgccccgact gcatctgcgt gttttcgcca atgacaagac gctgggcggg 2160 gtttgtgtca tcatagaact aaagacatgc aaatatattt cttccgggga caccgccagc 2220 aaacgcgagc aacgggccac ggggatgaag cagctggaag acta 2264 <210> 324 <211> 2264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 324 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggcatcaa gcaaatgtac atgtccctgc cccagggtga 300 gaaaatccaa gccatgtata tctgggttga tggtaccgga gaaggactgc gctgcaagac 360 ccgtaccctg gactgtgacc ccaagtgtgt ggaagagtta cctgagtgga actttgatgg 420 ctctagtacc tttcagtctg aaggctccaa cagcgacatg tacctccatc ctgttgccat 480 gtttcgggac cccttccgca aagaccccaa caagctggtg ctatgtgaag ttttcaagta 540 taaccggaag cctgcagaaa ccaacttgag gcacatctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga gcaggaatat actcttatgg gaacagacgg 660 ccacccattt ggttggcctt ccaatggctt ccctggaccc caaggcccgt attactgcgg 720 tgtgggagca gacaaggcct acggcaggga catcgtggag gctcactacc gggcctgctt 780 gtatgctgga gtcaagatca cggggacaaa tgcggaggtt atgcctgccc agtgggaatt 840 ccagatagga ccctgtgagg gaatccgaat gggagatcat ctttggatag cccgttttat 900 cttgcatcgg gtgtgcgaag attttggggt gatagcaacc tttgacccca agcccattcc 960 agggaactgg aatggtgcag gctgccatac caacttcagc accaaggcca tgcgggagga 1020 gaatggtctg aagtgcattg aggaggccat tgacaaactg agcaagaggc accagtacca 1080 catccgcgcc tacgatccca aggggggcct ggacaacgcc cggcgtctga ctggattcca 1140 cgaaacctcc aacatcaacg acttttctgc cggtgttgcc aaccgctccg ccagtatccg 1200 cattccccgg actgtcggcc aggagaagaa gggctacttt gaggaccgtc ggccttctgc 1260 caattgtgac ccctatgcgg tgacagaagc catcgtccgc acgtgtctcc tcaacgaaac 1320 aggcgacgaa cccttccaat acaagaacta ataattagac tttgagtgat cttgagcctt 1380 tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt 1440 gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt 1500 ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc 1560 tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc 1620 tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct 1680 ccaaaaaaga agagaaaggt agaagatccc aaggactttc cttcagaatt gctaagtttt 1740 ttgagtcatg ctgtgtttag taatagaact cttgcttgct ttgctattta caccacaaag 1800 gaaaaagctg cactgctata caagaaaatt atggaaaaat attctgtaac ctttataagt 1860 aggcataaca gttataatca taacatactg ttttttctta ctccacacag gcatagagtg 1920 tctgctatta ataactatgc tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg 1980 gttaataagg aatatttgat gtatagtgcc ttgactagag atcataatca gccataccac 2040 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 2100 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 2160 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 2220 tttgtccaaa ctcatcaatg tatcttatca tgtctggaag acac 2264 <210> 325 <211> 1588 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 325 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 gtttttgtat tggaagggct cgtcgccagt ctcattgaga aggcatgtgc ggacgatggc 300 ttctgtcact gcaaaggggt cacaattggc agaggggcgg cgatcttcaa agtaaccttt 360 cttctcctgg ccgacagtcc ggggaatgcg gatgctggca ctgcgattgg cgacaccagc 420 agaaaagtcg ttgatgttgg acgtttcgtg gaacccagtc agacgacggg cattgtccag 480 gccccccttg ggatcgtagg ctcgaatgtg gtacctgtgc cgcttgctta gtttctcgat 540 ggcctcctcg atgtgcttca gaccattctc ctcccgcatg gccttggtgc taaagttggt 600 atggcagcct gcaccattcc agttcccagg aatgggcttg gggtcaaagg ttgctattac 660 cccaaagtcc tcacatactc gatgcaagat gaaacgggcc acccagagat gatctcccat 720 gcggattcct tcacagggtc ctatttggaa ctcccactgg gcaggcatga cctcagcatt 780 tgttcctgta atcttgaccc cagcatacaa gcaggcgcgg tagtgagcct ccacgatatc 840 cctgccatag gctttgtctg cgcccacacc acagtaatac ggaccttggg gcccaggaaa 900 gccattggaa ggccaaccaa aagggtgccc atctgttccc atcagagtat actcctgttc 960 cattccaaac caggggtgct ggttgctcac catgtccatt atccgtttac acgagtgcct 1020 taaatttgtc tctgcaggct tccggttgta cttgaaaact tcacagaaca ccagcttgtt 1080 gggatctctg cggaaggggt cccgaaacat ggcaacaggg ctgagataca tgtcactgtt 1140 ggagccctca gactgaaagg tactagagcc atcaaaattc cactcaggta actcttctac 1200 acacttgggc tcacagtcca gggtgcgggt tttgcagcgc agtccttctc cagtaccatc 1260 aacccagata tacatggctt ggactttctc accctggggc aggcacaagt acatttgctt 1320 gatgtttttg ttcaagtggg aacttgctga ggtggccatg ccaccctgca gagtcgctct 1380 gtgttcgagg ccacacgcgt caccttaata tgcgaagtgg acctgggacc gcgccgcccc 1440 gactgcatct gcgtgttttc gccaatgaca agacgctggg cggggtttgt gtcatcatag 1500 aactaaagac atgcaaatat atttcttccg gggacaccgc cagcaaacgc gagcaacggg 1560 ccacggggat gaagcagctg gaagacta 1588 <210> 326 <211> 1910 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 326 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ttgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc acaggtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaacta ataattagac tttgagtgat cttgagcctt 1380 tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta cttctgtggt 1440 gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt 1500 ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc 1560 tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc 1620 tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct 1680 taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc ccctgaacct 1740 gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta 1800 caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag 1860 ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggaagacac 1910 <210> 327 <211> 1973 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 327 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ttgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc acaggtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 ccttaccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 1800 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 1860 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 1920 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggaaga cac 1973 <210> 328 <211> 2533 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 328 atgtcttcct cgagaaatct caaaacgcgt atttcggaca aacacacatt ttattattca 60 ctgcagtcac cgtccttgac acgaagctag atccagacat gataagatac attgatgagt 120 ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg 180 ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca 240 ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc 300 tctacaaatg tggtatggct gattatgatc tctagtcaag gcactataca tcaaatattc 360 cttattaacc cctttacaaa ttaaaaagct aaaggtacac aatttttgag catagttatt 420 aatagcagac actctatgcc tgtgtggagt aagaaaaaac agtatgttat gattataact 480 gttatgccta cttataaagg ttacagaata tttttccata attttcttgt atagcagtgc 540 agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga gttctattac taaacacagc 600 atgactcaaa aaacttagca attctgaagg aaagtccttg ggatcttcta cctttctctt 660 cttttttgga ggagtagaat gttgagagtc agcagtagcc tcatcatcac tagatggcat 720 ttcttctgag caaaacaggt tttcctcatt aaaggcattc caccactgct cccattcatc 780 agttccatag gttggaatct aaaatacaca aacaattaga atcagtagtt taacacatta 840 tacacttaaa aattttatat ttaccttaga gctttaaatc tctgtaggta gtttgtccaa 900 ttatgtcaca ccacagaagt aaggttcctt cacaaagatc tctctggggc ggggtgggat 960 gaactaggaa aggctcaaga tcactcaaag tctaattagt ttttgtattg gaagggctcg 1020 tcgccagtct cattgagaag gcatgtgcgg acgatggctt ctgtcactgc aaaggggtca 1080 caattggcag aggggcggcg atcttcaaag taacctttct tctcctggcc gacagtccgg 1140 ggaatgcgga tgctggcact gcgattggcg acaccagcag aaaagtcgtt gatgttggac 1200 gtttcgtgga acccagtcag acgacgggca ttgtccaggc cccccttggg atcgtaggct 1260 cgaatgtggt accggtgccg cttgcttagt ttctcgatgg cctcctcgat gtgcttcaga 1320 ccattctcct cccgcatggc cttggtgcta aagttggtat ggcagcctgc accattccag 1380 ttcccaggaa tgggcttggg gtcaaaggtt gctattaccc caaagtcctc acatactcga 1440 tgcaagatga aacgggccac ccagagatga tctcccatgc ggattccttc acagggtcct 1500 atttggaact cccactgggc aggcatgacc tcagcatttg ttcctgtaat cttgacccca 1560 gcatacaagc aggcgcggta gtgagcctcc acgatatccc tgccataggc tttgtctgcg 1620 cccacaccac agtaatacgg accttggggc ccaggaaagc cattggaagg ccaaccaaaa 1680 gggtgcccat ctgttcccat cagagtatac tcctgttcca ttccaaacca ggggtgctgg 1740 ttgctcacca tgtccattat ccgtttacac gagtgcctta aattagtctc tgcaggcttc 1800 cggttgtact tgaaaacttc acagaacacc agcttgttgg gatctctgcg gaaggggtcc 1860 cgaaacatgg caacagggct gagatacatg tcactgttgg agccctcaga ctgaaaggta 1920 ctagagccat caaaattcca ctcaggtaac tcttctacac acttgggctc acagtccagg 1980 gtgcgggttt tgcagcgcag tccttctcca gtaccatcaa cccagatata catggcttgg 2040 actttctcac cctggggcag gcacaagtac atttgcttga tgtttttgtt caagtgggaa 2100 cttgctgagg tggccatgtg aagtgtccca gcctgtttat ctacggctta aaaagtgttc 2160 gaggggaaaa taggttgcgc gagattatag agatctggcg cactaaaaac cagtatttca 2220 catgagtccg cgtcttttta cgcactgcct ctccctgacg cgggataaag tggtattctc 2280 aaacatatct cgcaagcctg tcttgtgtcc ctgcagagtc gctctgtgtt cgaggccaca 2340 cgcgtcacct taatatgcga agtggacctg ggaccgcgcc gccccgactg catctgcgtg 2400 ttttcgccaa tgacaagacg ctgggcgggg tttgtgtcat catagaacta aagacatgca 2460 aatatatttc ttccggggac accgccagca aacgcgagca acgggccacg gggatgaagc 2520 agctggaaga cta 2533 <210> 329 <211> 2596 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 329 atgtcttcct cgagaaatct caaaacgcgt atttcggaca aacacacatt ttattattca 60 ctgcagtcac cgtccttgac acgaagctag atccagacat gataagatac attgatgagt 120 ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg 180 ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca 240 ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc 300 tctacaaatg tggtatggct gattatgatc tctagtcaag gcactataca tcaaatattc 360 cttattaacc cctttacaaa ttaaaaagct aaaggtacac aatttttgag catagttatt 420 aatagcagac actctatgcc tgtgtggagt aagaaaaaac agtatgttat gattataact 480 gttatgccta cttataaagg ttacagaata tttttccata attttcttgt atagcagtgc 540 agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga gttctattac taaacacagc 600 atgactcaaa aaacttagca attctgaagg aaagtccttg ggatcttcta cctttctctt 660 cttttttgga ggagtagaat gttgagagtc agcagtagcc tcatcatcac tagatggcat 720 ttcttctgag caaaacaggt tttcctcatt aaaggcattc caccactgct cccattcatc 780 agttccatag gttggaatct aaaatacaca aacaattaga atcagtagtt taacacatta 840 tacacttaaa aattttatat ttaccttaga gctttaaatc tctgtaggta gtttgtccaa 900 ttatgtcaca ccacagaagt aaggttcctt cacaaagatc tctctggggc ggggtgggat 960 gaactaggaa aggctcaaga tcactcaaag tctaatcatt gcatccgtgt agtggtctga 1020 ccgaattcgt cgatatatct gatcatatcg cttctaatcc agtttttgta ttggaagggc 1080 tcgtcgccag tctcattgag aaggcatgtg cggacgatgg cttctgtcac tgcaaagggg 1140 tcacaattgg cagaggggcg gcgatcttca aagtaacctt tcttctcctg gccgacagtc 1200 cggggaatgc ggatgctggc actgcgattg gcgacaccag cagaaaagtc gttgatgttg 1260 gacgtttcgt ggaacccagt cagacgacgg gcattgtcca ggcccccctt gggatcgtag 1320 gctcgaatgt ggtaccggtg ccgcttgctt agtttctcga tggcctcctc gatgtgcttc 1380 agaccattct cctcccgcat ggccttggtg ctaaagttgg tatggcagcc tgcaccattc 1440 cagttcccag gaatgggctt ggggtcaaag gttgctatta ccccaaagtc ctcacatact 1500 cgatgcaaga tgaaacgggc cacccagaga tgatctccca tgcggattcc ttcacagggt 1560 cctatttgga actcccactg ggcaggcatg acctcagcat ttgttcctgt aatcttgacc 1620 ccagcataca agcaggcgcg gtagtgagcc tccacgatat ccctgccata ggctttgtct 1680 gcgcccacac cacagtaata cggaccttgg ggcccaggaa agccattgga aggccaacca 1740 aaagggtgcc catctgttcc catcagagta tactcctgtt ccattccaaa ccaggggtgc 1800 tggttgctca ccatgtccat tatccgttta cacgagtgcc ttaaattagt ctctgcaggc 1860 ttccggttgt acttgaaaac ttcacagaac accagcttgt tgggatctct gcggaagggg 1920 tcccgaaaca tggcaacagg gctgagatac atgtcactgt tggagccctc agactgaaag 1980 gtactagagc catcaaaatt ccactcaggt aactcttcta cacacttggg ctcacagtcc 2040 agggtgcggg ttttgcagcg cagtccttct ccagtaccat caacccagat atacatggct 2100 tggactttct caccctgggg caggcacaag tacatttgct tgatgttttt gttcaagtgg 2160 gaacttgctg aggtggccat gtgaagtgtc ccagcctgtt tatctacggc ttaaaaagtg 2220 ttcgagggga aaataggttg cgcgagatta tagagatctg gcgcactaaa aaccagtatt 2280 tcacatgagt ccgcgtcttt ttacgcactg cctctccctg acgcgggata aagtggtatt 2340 ctcaaacata tctcgcaagc ctgtcttgtg tccctgcaga gtcgctctgt gttcgaggcc 2400 acacgcgtca ccttaatatg cgaagtggac ctgggaccgc gccgccccga ctgcatctgc 2460 gtgttttcgc caatgacaag acgctgggcg gggtttgtgt catcatagaa ctaaagacat 2520 gcaaatatat ttcttccggg gacaccgcca gcaaacgcga gcaacgggcc acggggatga 2580 agcagctgga agacta 2596 <210> 330 <211> 2160 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 330 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacttg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgcagag atcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcgtgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccgcatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcaca 1260 ggtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 1980 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 2040 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 2100 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggaagacac 2160 <210> 331 <211> 2067 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 331 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 cctccacaga cctggtgacc gtcaggaaga agattcagtg agaggacacg aggtatgtca 1800 tggtttttaa tcaataaata aagaggtttt attcatcgga cagtcgttgt agcctgtaaa 1860 agactcgccc cggagggggt tcccccgatg tgaggggcat gcagtagtat ggtgtcctga 1920 gtgtctcgga tgcgtccttg aactcgcact ctaccgccgt gggggttaat aaagttttgc 1980 tgcgccggta gggggggagg ccgaggataa taaagttgct acgtactggt tgaagtctaa 2040 caatctctcg gggggatccg aagacac 2067 <210> 332 <211> 1961 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 332 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaaacatcaa gcaaatgtac ctgtgcctgc cccagggtga 300 gaaagtccaa gccatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgagc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat 480 gtttcgggac cccttccgcc gggagcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg gtcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccacat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg aagcacatcg aggaggccat cgagaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg actgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctttgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 cctctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact 1800 actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca 1860 tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat 1920 gtgggaggtc agtgcattta aaacataaag aaagaagaca c 1961 <210> 333 <211> 2067 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 333 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggcatcaa gcaaatgtac atgtccctgc cccagggtga 300 gaaaatccaa gccatgtata tctgggttga tggtaccgga gaaggactgc gctgcaagac 360 ccgtaccctg gactgtgacc ccaagtgtgt ggaagagtta cctgagtgga actttgatgg 420 ctctagtacc tttcagtctg aaggctccaa cagcgacatg tacctccatc ctgttgccat 480 gtttcgggac cccttccgca aagaccccaa caagctggtg ctatgtgaag ttttcaagta 540 taaccggaag cctgcagaaa ccaacttgag gcacatctgt aaacggataa tggacatggt 600 gagcaaccag cacccctggt ttggaatgga gcaggaatat actcttatgg gaacagacgg 660 ccacccattt ggttggcctt ccaatggctt ccctggaccc caaggcccgt attactgcgg 720 tgtgggagca gacaaggcct acggcaggga catcgtggag gctcactacc gggcctgctt 780 gtatgctgga gtcaagatca cggggacaaa tgcggaggtt atgcctgccc agtgggaatt 840 ccagatagga ccctgtgagg gaatccgaat gggagatcat ctttggatag cccgttttat 900 cttgcatcgg gtgtgcgaag attttggggt gatagcaacc tttgacccca agcccattcc 960 agggaactgg aatggtgcag gctgccatac caacttcagc accaaggcca tgcgggagga 1020 gaatggtctg aagtgcattg aggaggccat tgacaaactg agcaagaggc accagtacca 1080 catccgcgcc tacgatccca aggggggcct ggacaacgcc cggcgtctga ctggattcca 1140 cgaaacctcc aacatcaacg acttttctgc cggtgttgcc aaccgctccg ccagtatccg 1200 cattccccgg actgtcggcc aggagaagaa gggctacttt gaggaccgtc ggccttctgc 1260 caattgtgac ccctatgcgg tgacagaagc catcgtccgc acgtgtctcc tcaacgaaac 1320 aggcgacgaa cccttccaat acaagaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 cctccacaga cctggtgacc gtcaggaaga agattcagtg agaggacacg aggtatgtca 1800 tggtttttaa tcaataaata aagaggtttt attcatcgga cagtcgttgt agcctgtaaa 1860 agactcgccc cggagggggt tcccccgatg tgaggggcat gcagtagtat ggtgtcctga 1920 gtgtctcgga tgcgtccttg aactcgcact ctaccgccgt gggggttaat aaagttttgc 1980 tgcgccggta gggggggagg ccgaggataa taaagttgct acgtactggt tgaagtctaa 2040 caatctctcg gggggatccg aagacac 2067 <210> 334 <211> 2067 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 334 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 cctccacaga cctggtgacc gtcaggaaga agattcagtg agaggacacg aggtatgtca 1800 tggtttttaa tcaataaata aagaggtttt attcatcgga cagtcgttgt agcctgtaaa 1860 agactcgccc cggagggggt tcccccgatg tgaggggcat gcagtagtat ggtgtcctga 1920 gtgtctcgga tgcgtccttg aactcgcact ctaccgccgt gggggttaat aaagttttgc 1980 tgcgccggta gggggggagg ccgaggataa taaagttgct acgtactggt tgaagtctaa 2040 caatctctcg gggggatccg aagacac 2067 <210> 335 <211> 1961 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 335 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggtggca tggccacctc 240 agcaagttcc cacttgaaca aaggaatcaa gcaaatgtac atgaacctgc cccagggtga 300 gaaaatccaa ctgatgtata tctgggttga tggtactgga gaaggactgc gctgcaaaac 360 ccgcaccctg gactgtgacc ccaagtgtgt agaagagtta cctgagtgga attttgatgg 420 ctctagtacc tttcagtctg agggctccaa cagtgacatg tatctccacc ctgttgccat 480 gtttcgggac cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta 540 caaccggaag cctgcagaga caaatttaag gcactcgtgt aaacggataa tggacatggt 600 gagctcccag cacccctggt ttggaatgga acaggagtat actctgatgg gaacagatgg 660 gcaccctttt ggttggcctt ccaatggctt tcctgggccc caaggtccgt attactgtgg 720 tgtgggcgca gacaaagcct atggcaggga tatcgtggag gctcactacc gcgcctgctt 780 gtatgctggg atcaagatta caggaacaaa tgctgaggtc atgcctgccc agtgggagtt 840 ccaaatagga ccctgtgaag gaatccgcat gggagatcat ctctgggtgg cccgtttcat 900 cttgcatcga gtatgtgagg actttggggt aatagcaacc tttgacccca agcccattcc 960 tgggaactgg aatggtgcag gctgccatac caactttagc accaaggcca tgcgggagga 1020 gaatggtctg cggtgcatcg aggaggccat cgacaaacta agcaagcggc accagtacca 1080 cattcgagcc tacgatccca aggggggcct ggacaatgcc cgtcgtctga ctgggttcca 1140 cgaaacgtcc aacatcaacg acttttctgc tggtgtcgcc aatcgcagtg ccagcatccg 1200 cattccccgg atcgtcggcc aggagaagaa aggttacttt gaagatcgcc gcccctctgc 1260 caattgtgac ccctacgcag tgacagaagc catcgtccgc acatgccttc tcaatgagac 1320 tggcgacgag cccttccaat acaaaaactg gatccgctca gacatgataa gatacattga 1380 tgagtttgga caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc 1440 ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt 1500 ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa 1560 tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca 1620 acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt 1680 tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact 1740 cctctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact 1800 actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca 1860 tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat 1920 gtgggaggtc agtgcattta aaacataaag aaagaagaca c 1961 <210> 336 <211> 2254 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 336 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gcatcaagca aatgtacatg tccctgcccc 480 agggtgagaa aatccaagcc atgtatatct gggttgatgg taccggagaa ggactgcgct 540 gcaagacccg taccctggac tgtgacccca agtgtgtgga agagttacct gagtggaact 600 ttgatggctc tagtaccttt cagtctgaag gctccaacag cgacatgtac ctccatcctg 660 ttgccatgtt tcgggacccc ttccgcaaag accccaacaa gctggtgcta tgtgaagttt 720 tcaagtataa ccggaagcct gcagaaacca acttgaggca catctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggagca ggaatatact cttatgggaa 840 cagacggcca cccatttggt tggccttcca atggcttccc tggaccccaa ggcccgtatt 900 actgcggtgt gggagcagac aaggcctacg gcagggacat cgtggaggct cactaccggg 960 cctgcttgta tgctggagtc aagatcacgg ggacaaatgc ggaggttatg cctgcccagt 1020 gggaattcca gataggaccc tgtgagggaa tccgaatggg agatcatctt tggatagccc 1080 gttttatctt gcatcgggtg tgcgaagatt ttggggtgat agcaaccttt gaccccaagc 1140 ccattccagg gaactggaat ggtgcaggct gccataccaa cttcagcacc aaggccatgc 1200 gggaggagaa tggtctgaag tgcattgagg aggccattga caaactgagc aagaggcacc 1260 agtaccacat ccgcgcctac gatcccaagg ggggcctgga caacgcccgg cgtctgactg 1320 gattccacga aacctccaac atcaacgact tttctgccgg tgttgccaac cgctccgcca 1380 gtatccgcat tccccggact gtcggccagg agaagaaggg ctactttgag gaccgtcggc 1440 cttctgccaa ttgtgacccc tatgcggtga cagaagccat cgtccgcacg tgtctcctca 1500 acgaaacagg cgacgaaccc ttccaataca agaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ccacagacct ggtgaccgtc aggaagaaga ttcagtgaga ggacacgagg 1980 tatgtcatgg tttttaatca ataaataaag aggttttatt catcggacag tcgttgtagc 2040 ctgtaaaaga ctcgccccgg agggggttcc cccgatgtga ggggcatgca gtagtatggt 2100 gtcctgagtg tctcggatgc gtccttgaac tcgcactcta ccgccgtggg ggttaataaa 2160 gttttgctgc gccggtaggg ggggaggccg aggataataa agttgctacg tactggttga 2220 agtctaacaa tctctcgggg ggatccgaag acac 2254 <210> 337 <211> 2254 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 337 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gaatcaagca aatgtacatg aacctgcccc 480 agggtgagaa aatccaactg atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgacccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctccaccctg 660 ttgccatgtt tcgggacccc ttccgcagag atcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcgtgtaaa cggataatgg 780 acatggtgag ctcccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctgggatc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccgcatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgcgg tgcatcgagg aggccatcga caaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggatc gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tacgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ccacagacct ggtgaccgtc aggaagaaga ttcagtgaga ggacacgagg 1980 tatgtcatgg tttttaatca ataaataaag aggttttatt catcggacag tcgttgtagc 2040 ctgtaaaaga ctcgccccgg agggggttcc cccgatgtga ggggcatgca gtagtatggt 2100 gtcctgagtg tctcggatgc gtccttgaac tcgcactcta ccgccgtggg ggttaataaa 2160 gttttgctgc gccggtaggg ggggaggccg aggataataa agttgctacg tactggttga 2220 agtctaacaa tctctcgggg ggatccgaag acac 2254 <210> 338 <211> 2148 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 338 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gaatcaagca aatgtacatg aacctgcccc 480 agggtgagaa aatccaactg atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgacccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctccaccctg 660 ttgccatgtt tcgggacccc ttccgcagag atcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcgtgtaaa cggataatgg 780 acatggtgag ctcccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctgggatc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccgcatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgcgg tgcatcgagg aggccatcga caaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggatc gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tacgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag 1980 tccaactact aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata 2040 aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa 2100 agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa gaagacac 2148 <210> 339 <211> 2254 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 339 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacctg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgccggg agcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccacatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ccacagacct ggtgaccgtc aggaagaaga ttcagtgaga ggacacgagg 1980 tatgtcatgg tttttaatca ataaataaag aggttttatt catcggacag tcgttgtagc 2040 ctgtaaaaga ctcgccccgg agggggttcc cccgatgtga ggggcatgca gtagtatggt 2100 gtcctgagtg tctcggatgc gtccttgaac tcgcactcta ccgccgtggg ggttaataaa 2160 gttttgctgc gccggtaggg ggggaggccg aggataataa agttgctacg tactggttga 2220 agtctaacaa tctctcgggg ggatccgaag acac 2254 <210> 340 <211> 2148 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 340 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacctg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgccggg agcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccacatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag 1980 tccaactact aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata 2040 aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa 2100 agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa gaagacac 2148 <210> 341 <211> 2147 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 341 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacctg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgccggg agcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccacatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactggat ccgctcagac atgataagat 1560 acattgatga gtttggacaa accacaacta gaatgcagtg ataattagac tttgagtgat 1620 cttgagcctt tcctagttca tcccaccccg ccccagagag atctttgtga aggaacctta 1680 cttctgtggt gtgacataat tggacaaact acctacagag atttaaagct ctaaggtaaa 1740 tataaaattt ttaagtgtat aatgtgttaa actactgatt ctaattgttt gtgtatttta 1800 gattccaacc tatggaactg atgaatggga gcagtggtgg aatgccttta atgaggaaaa 1860 cctgttttgc tcagaagaaa tgccatctag tgatgatgag gctactgctg actctcaaca 1920 ttctactcct ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag 1980 tccaactact aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata 2040 aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat tttactaaaa 2100 agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa gaagacc 2147 <210> 342 <211> 2191 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 342 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacctg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgccggg agcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccacatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactaata attagacttt gagtgatctt 1560 gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg aaccttactt 1620 ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta aggtaaatat 1680 aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg tattttagat 1740 tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg aggaaaacct 1800 gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact ctcaacattc 1860 tactcctcca cagacctggt gaccgtcagg aagaagattc agtgagagga cacgaggtat 1920 gtcatggttt ttaatcaata aataaagagg ttttattcat cggacagtcg ttgtagcctg 1980 taaaagactc gccccggagg gggttccccc gatgtgaggg gcatgcagta gtatggtgtc 2040 ctgagtgtct cggatgcgtc cttgaactcg cactctaccg ccgtgggggt taataaagtt 2100 ttgctgcgcc ggtagggggg gaggccgagg ataataaagt tgctacgtac tggttgaagt 2160 ctaacaatct ctcgggggga tccgaagaca c 2191 <210> 343 <211> 2085 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 343 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaaa acatcaagca aatgtacctg tgcctgcccc 480 agggtgagaa agtccaagcc atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgagccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctcagccctg 660 ttgccatgtt tcgggacccc ttccgccggg agcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccacatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgaag cacatcgagg aggccatcga gaaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggact gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tttgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactaata attagacttt gagtgatctt 1560 gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg aaccttactt 1620 ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta aggtaaatat 1680 aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg tattttagat 1740 tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg aggaaaacct 1800 gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact ctcaacattc 1860 tactcctctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc 1920 aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa 1980 aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg 2040 gaatgtggga ggtcagtgca tttaaaacat aaagaaagaa gacac 2085 <210> 344 <211> 2191 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 344 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gcatcaagca aatgtacatg tccctgcccc 480 agggtgagaa aatccaagcc atgtatatct gggttgatgg taccggagaa ggactgcgct 540 gcaagacccg taccctggac tgtgacccca agtgtgtgga agagttacct gagtggaact 600 ttgatggctc tagtaccttt cagtctgaag gctccaacag cgacatgtac ctccatcctg 660 ttgccatgtt tcgggacccc ttccgcaaag accccaacaa gctggtgcta tgtgaagttt 720 tcaagtataa ccggaagcct gcagaaacca acttgaggca catctgtaaa cggataatgg 780 acatggtgag caaccagcac ccctggtttg gaatggagca ggaatatact cttatgggaa 840 cagacggcca cccatttggt tggccttcca atggcttccc tggaccccaa ggcccgtatt 900 actgcggtgt gggagcagac aaggcctacg gcagggacat cgtggaggct cactaccggg 960 cctgcttgta tgctggagtc aagatcacgg ggacaaatgc ggaggttatg cctgcccagt 1020 gggaattcca gataggaccc tgtgagggaa tccgaatggg agatcatctt tggatagccc 1080 gttttatctt gcatcgggtg tgcgaagatt ttggggtgat agcaaccttt gaccccaagc 1140 ccattccagg gaactggaat ggtgcaggct gccataccaa cttcagcacc aaggccatgc 1200 gggaggagaa tggtctgaag tgcattgagg aggccattga caaactgagc aagaggcacc 1260 agtaccacat ccgcgcctac gatcccaagg ggggcctgga caacgcccgg cgtctgactg 1320 gattccacga aacctccaac atcaacgact tttctgccgg tgttgccaac cgctccgcca 1380 gtatccgcat tccccggact gtcggccagg agaagaaggg ctactttgag gaccgtcggc 1440 cttctgccaa ttgtgacccc tatgcggtga cagaagccat cgtccgcacg tgtctcctca 1500 acgaaacagg cgacgaaccc ttccaataca agaactaata attagacttt gagtgatctt 1560 gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg aaccttactt 1620 ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta aggtaaatat 1680 aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg tattttagat 1740 tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg aggaaaacct 1800 gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact ctcaacattc 1860 tactcctcca cagacctggt gaccgtcagg aagaagattc agtgagagga cacgaggtat 1920 gtcatggttt ttaatcaata aataaagagg ttttattcat cggacagtcg ttgtagcctg 1980 taaaagactc gccccggagg gggttccccc gatgtgaggg gcatgcagta gtatggtgtc 2040 ctgagtgtct cggatgcgtc cttgaactcg cactctaccg ccgtgggggt taataaagtt 2100 ttgctgcgcc ggtagggggg gaggccgagg ataataaagt tgctacgtac tggttgaagt 2160 ctaacaatct ctcgggggga tccgaagaca c 2191 <210> 345 <211> 2191 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 345 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gaatcaagca aatgtacatg aacctgcccc 480 agggtgagaa aatccaactg atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgacccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctccaccctg 660 ttgccatgtt tcgggacccc ttccgcagag atcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcgtgtaaa cggataatgg 780 acatggtgag ctcccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctgggatc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccgcatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgcgg tgcatcgagg aggccatcga caaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggatc gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tacgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactaata attagacttt gagtgatctt 1560 gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg aaccttactt 1620 ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta aggtaaatat 1680 aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg tattttagat 1740 tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg aggaaaacct 1800 gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact ctcaacattc 1860 tactcctcca cagacctggt gaccgtcagg aagaagattc agtgagagga cacgaggtat 1920 gtcatggttt ttaatcaata aataaagagg ttttattcat cggacagtcg ttgtagcctg 1980 taaaagactc gccccggagg gggttccccc gatgtgaggg gcatgcagta gtatggtgtc 2040 ctgagtgtct cggatgcgtc cttgaactcg cactctaccg ccgtgggggt taataaagtt 2100 ttgctgcgcc ggtagggggg gaggccgagg ataataaagt tgctacgtac tggttgaagt 2160 ctaacaatct ctcgggggga tccgaagaca c 2191 <210> 346 <211> 2085 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 346 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatgg 420 ccacctcagc aagttcccac ttgaacaaag gaatcaagca aatgtacatg aacctgcccc 480 agggtgagaa aatccaactg atgtatatct gggttgatgg tactggagaa ggactgcgct 540 gcaaaacccg caccctggac tgtgacccca agtgtgtaga agagttacct gagtggaatt 600 ttgatggctc tagtaccttt cagtctgagg gctccaacag tgacatgtat ctccaccctg 660 ttgccatgtt tcgggacccc ttccgcagag atcccaacaa gctggtgttc tgtgaagttt 720 tcaagtacaa ccggaagcct gcagagacaa atttaaggca ctcgtgtaaa cggataatgg 780 acatggtgag ctcccagcac ccctggtttg gaatggaaca ggagtatact ctgatgggaa 840 cagatgggca cccttttggt tggccttcca atggctttcc tgggccccaa ggtccgtatt 900 actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct cactaccgcg 960 cctgcttgta tgctgggatc aagattacag gaacaaatgc tgaggtcatg cctgcccagt 1020 gggagttcca aataggaccc tgtgaaggaa tccgcatggg agatcatctc tgggtggccc 1080 gtttcatctt gcatcgagta tgtgaggact ttggggtaat agcaaccttt gaccccaagc 1140 ccattcctgg gaactggaat ggtgcaggct gccataccaa ctttagcacc aaggccatgc 1200 gggaggagaa tggtctgcgg tgcatcgagg aggccatcga caaactaagc aagcggcacc 1260 agtaccacat tcgagcctac gatcccaagg ggggcctgga caatgcccgt cgtctgactg 1320 ggttccacga aacgtccaac atcaacgact tttctgctgg tgtcgccaat cgcagtgcca 1380 gcatccgcat tccccggatc gtcggccagg agaagaaagg ttactttgaa gatcgccgcc 1440 cctctgccaa ttgtgacccc tacgcagtga cagaagccat cgtccgcaca tgccttctca 1500 atgagactgg cgacgagccc ttccaataca aaaactaata attagacttt gagtgatctt 1560 gagcctttcc tagttcatcc caccccgccc cagagagatc tttgtgaagg aaccttactt 1620 ctgtggtgtg acataattgg acaaactacc tacagagatt taaagctcta aggtaaatat 1680 aaaattttta agtgtataat gtgttaaact actgattcta attgtttgtg tattttagat 1740 tccaacctat ggaactgatg aatgggagca gtggtggaat gcctttaatg aggaaaacct 1800 gttttgctca gaagaaatgc catctagtga tgatgaggct actgctgact ctcaacattc 1860 tactcctctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc 1920 aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa 1980 aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt actaaaaagg 2040 gaatgtggga ggtcagtgca tttaaaacat aaagaaagaa gacac 2085 <210> 347 <211> 1846 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 347 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg tggcatggcc 120 acctcagcaa gttcccactt gaacaaaaac atcaagcaaa tgtacctgtg cctgccccag 180 ggtgagaaag tccaagccat gtatatctgg gttgatggta ctggagaagg actgcgctgc 240 aaaacccgca ccctggactg tgagcccaag tgtgtagaag agttacctga gtggaatttt 300 gatggctcta gtacctttca gtctgagggc tccaacagtg acatgtatct cagccctgtt 360 gccatgtttc gggacccctt ccgccgggag cccaacaagc tggtgttctg tgaagttttc 420 aagtacaacc ggaagcctgc agagacaaat ttaaggcact cctgtaaacg gataatggac 480 atggtgagca accagcaccc ctggtttgga atggaacagg agtatactct gatgggaaca 540 gatgggcacc cttttggttg gccttccaat ggctttcctg ggccccaagg tccgtattac 600 tgtggtgtgg gcgcagacaa agcctatggc agggatatcg tggaggctca ctaccgcgcc 660 tgcttgtatg ctggggtcaa gattacagga acaaatgctg aggtcatgcc tgcccagtgg 720 gagttccaaa taggaccctg tgaaggaatc cacatgggag atcatctctg ggtggcccgt 780 ttcatcttgc atcgagtatg tgaggacttt ggggtaatag caacctttga ccccaagccc 840 attcctggga actggaatgg tgcaggctgc cataccaact ttagcaccaa ggccatgcgg 900 gaggagaatg gtctgaagca catcgaggag gccatcgaga aactaagcaa gcggcaccag 960 taccacattc gagcctacga tcccaagggg ggcctggaca atgcccgtcg tctgactggg 1020 ttccacgaaa cgtccaacat caacgacttt tctgctggtg tcgccaatcg cagtgccagc 1080 atccgcattc cccggactgt cggccaggag aagaaaggtt actttgaaga tcgccgcccc 1140 tctgccaatt gtgacccctt tgcagtgaca gaagccatcg tccgcacatg ccttctcaat 1200 gagactggcg acgagccctt ccaatacaaa aactggatcc gctcagacat gataagatac 1260 attgatgagt ttggacaaac cacaactaga atgcagtgat aattagactt tgagtgatct 1320 tgagcctttc ctagttcatc ccaccccgcc ccagagagat ctttgtgaag gaaccttact 1380 tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata 1440 taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga 1500 ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc 1560 tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt 1620 ctactcctct cgctttcttg ctgtccaatt tctattaaag gttcctttgt tccctaagtc 1680 caactactaa actgggggat attatgaagg gccttgagca tctggattct gcctaataaa 1740 aaacatttat tttcattgca atgatgtatt taaattattt ctgaatattt tactaaaaag 1800 ggaatgtggg aggtcagtgc atttaaaaca taaagaaaga agacac 1846 <210> 348 <211> 2212 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 348 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg tggcatggcc 120 acctcagcaa gttcccactt gaacaaaggc atcaagcaaa tgtacatgtc cctgccccag 180 ggtgagaaaa tccaagccat gtatatctgg gttgatggta ccggagaagg actgcgctgc 240 aagacccgta ccctggactg tgaccccaag tgtgtggaag agttacctga gtggaacttt 300 gatggctcta gtacctttca gtctgaaggc tccaacagcg acatgtacct ccatcctgtt 360 gccatgtttc gggacccctt ccgcaaagac cccaacaagc tggtgctatg tgaagttttc 420 aagtataacc ggaagcctgc agaaaccaac ttgaggcaca tctgtaaacg gataatggac 480 atggtgagca accagcaccc ctggtttgga atggagcagg aatatactct tatgggaaca 540 gacggccacc catttggttg gccttccaat ggcttccctg gaccccaagg cccgtattac 600 tgcggtgtgg gagcagacaa ggcctacggc agggacatcg tggaggctca ctaccgggcc 660 tgcttgtatg ctggagtcaa gatcacgggg acaaatgcgg aggttatgcc tgcccagtgg 720 gaattccaga taggaccctg tgagggaatc cgaatgggag atcatctttg gatagcccgt 780 tttatcttgc atcgggtgtg cgaagatttt ggggtgatag caacctttga ccccaagccc 840 attccaggga actggaatgg tgcaggctgc cataccaact tcagcaccaa ggccatgcgg 900 gaggagaatg gtctgaagtg cattgaggag gccattgaca aactgagcaa gaggcaccag 960 taccacatcc gcgcctacga tcccaagggg ggcctggaca acgcccggcg tctgactgga 1020 ttccacgaaa cctccaacat caacgacttt tctgccggtg ttgccaaccg ctccgccagt 1080 atccgcattc cccggactgt cggccaggag aagaagggct actttgagga ccgtcggcct 1140 tctgccaatt gtgaccccta tgcggtgaca gaagccatcg tccgcacgtg tctcctcaac 1200 gaaacaggcg acgaaccctt ccaatacaag aactggatcc gctcagatat gatccgctat 1260 atcgacgaat tcggccagac taccactcgc atgcaatgat aattagactt tgagtgatct 1320 tgagcctttc ctagttcatc ccaccccgcc ccagagagat ctttgtgaag gaaccttact 1380 tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata 1440 taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga 1500 ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc 1560 tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt 1620 ctactcctcc aaaaaagaag agaaaggtag aagatcccaa ggactttcct tcagaattgc 1680 taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca 1740 ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct 1800 ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc 1860 atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt 1920 gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc 1980 cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac 2040 ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt 2100 tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 2160 agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggaagac ac 2212 <210> 349 <211> 2149 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 349 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg tggcatggcc 120 acctcagcaa gttcccactt gaacaaaggc atcaagcaaa tgtacatgtc cctgccccag 180 ggtgagaaaa tccaagccat gtatatctgg gttgatggta ccggagaagg actgcgctgc 240 aagacccgta ccctggactg tgaccccaag tgtgtggaag agttacctga gtggaacttt 300 gatggctcta gtacctttca gtctgaaggc tccaacagcg acatgtacct ccatcctgtt 360 gccatgtttc gggacccctt ccgcaaagac cccaacaagc tggtgctatg tgaagttttc 420 aagtataacc ggaagcctgc agaaaccaac ttgaggcaca tctgtaaacg gataatggac 480 atggtgagca accagcaccc ctggtttgga atggagcagg aatatactct tatgggaaca 540 gacggccacc catttggttg gccttccaat ggcttccctg gaccccaagg cccgtattac 600 tgcggtgtgg gagcagacaa ggcctacggc agggacatcg tggaggctca ctaccgggcc 660 tgcttgtatg ctggagtcaa gatcacgggg acaaatgcgg aggttatgcc tgcccagtgg 720 gaattccaga taggaccctg tgagggaatc cgaatgggag atcatctttg gatagcccgt 780 tttatcttgc atcgggtgtg cgaagatttt ggggtgatag caacctttga ccccaagccc 840 attccaggga actggaatgg tgcaggctgc cataccaact tcagcaccaa ggccatgcgg 900 gaggagaatg gtctgaagtg cattgaggag gccattgaca aactgagcaa gaggcaccag 960 taccacatcc gcgcctacga tcccaagggg ggcctggaca acgcccggcg tctgactgga 1020 ttccacgaaa cctccaacat caacgacttt tctgccggtg ttgccaaccg ctccgccagt 1080 atccgcattc cccggactgt cggccaggag aagaagggct actttgagga ccgtcggcct 1140 tctgccaatt gtgaccccta tgcggtgaca gaagccatcg tccgcacgtg tctcctcaac 1200 gaaacaggcg acgaaccctt ccaatacaag aactaataat tagactttga gtgatcttga 1260 gcctttccta gttcatccca ccccgcccca gagagatctt tgtgaaggaa ccttacttct 1320 gtggtgtgac ataattggac aaactaccta cagagattta aagctctaag gtaaatataa 1380 aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta ttttagattc 1440 caacctatgg aactgatgaa tgggagcagt ggtggaatgc ctttaatgag gaaaacctgt 1500 tttgctcaga agaaatgcca tctagtgatg atgaggctac tgctgactct caacattcta 1560 ctcctccaaa aaagaagaga aaggtagaag atcccaagga ctttccttca gaattgctaa 1620 gttttttgag tcatgctgtg tttagtaata gaactcttgc ttgctttgct atttacacca 1680 caaaggaaaa agctgcactg ctatacaaga aaattatgga aaaatattct gtaaccttta 1740 taagtaggca taacagttat aatcataaca tactgttttt tcttactcca cacaggcata 1800 gagtgtctgc tattaataac tatgctcaaa aattgtgtac ctttagcttt ttaatttgta 1860 aaggggttaa taaggaatat ttgatgtata gtgccttgac tagagatcat aatcagccat 1920 accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg 1980 aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac 2040 aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt 2100 tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggaagacac 2149 <210> 350 <211> 2548 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 350 ttgtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggccacctca gcaagttccc acttgaacaa aaacatcaag caaatgtact 720 tgtgcctgcc ccagggtgag aaagtccaag ccatgtatat ctgggttgat ggtactggag 780 aaggactgcg ctgcaaaacc cgcaccctgg actgtgagcc caagtgtgta gaagagttac 840 ctgagtggaa ttttgatggc tctagtacct ttcagtctga gggctccaac agtgacatgt 900 atctcagccc tgttgccatg tttcgggacc ccttccgcag agatcccaac aagctggtgt 960 tctgtgaagt tttcaagtac aaccggaagc ctgcagagac aaatttaagg cactcgtgta 1020 aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa caggagtata 1080 ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt cctgggcccc 1140 aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat atcgtggagg 1200 ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat gctgaggtca 1260 tgcctgccca gtgggagttc caaataggac cctgtgaagg aatccgcatg ggagatcatc 1320 tctgggtggc ccgtttcatc ttgcatcgag tatgtgagga ctttggggta atagcaacct 1380 ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc aactttagca 1440 ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc gagaaactaa 1500 gcaagcggca caggtaccac attcgagcct acgatcccaa ggggggcctg gacaatgccc 1560 gtcgtctgac tgggttccac gaaacgtcca acatcaacga cttttctgct ggtgtcgcca 1620 atcgcagtgc cagcatccgc attccccgga ctgtcggcca ggagaagaaa ggttactttg 1680 aagatcgccg cccctctgcc aattgtgacc cctttgcagt gacagaagcc atcgtccgca 1740 catgccttct caatgagact ggcgacgagc ccttccaata caaaaactgg atccgctcag 1800 acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat 1860 gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata 1920 aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg 1980 aggtttttta aagcaagtaa aacctctaca aatgtggtaa aatcgataat atatggtagg 2040 gttcatagcc agagtaacct ttttttttaa tttttatttt attttatttt tgagtcgggc 2100 gcgccaaaat gaagtgaagt tcctatactt tctagataga ctctgggtag aatgttctgt 2160 ttcctgtaat ataaaatcat aaagtgatga tattatcaag tgaaaaggaa atgtggtacc 2220 ttaatctttc cacatcaagc caatatcatg ctgaaggcca gagaatcttt tttgctaaaa 2280 aacacaatac agatataatt aatagttatc atttatgttt gatattaatc atatgaatat 2340 aattaatatg ttttattgta tcgattattg ttgatattaa tgtaattact actaatacat 2400 aacaaatata actaatggtt atggctcagt aactaaggta agatataagc tacactggta 2460 aagaaagatc aatattgctt cagagtacac tgaagtaaat gaataactta accggtctag 2520 gttgtcactt atatttatac gaagactt 2548 <210> 351 <211> 1868 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 351 gtgtcttctt tctttatgtt ttaaatgcac tgatctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtt agtttttgta ttggaagggc 240 tcgtcgccag tctcattgag aaggcatgtg cggacgatgg cttctgtcac tgcaaagggg 300 tcacaattgg cagaggggcg gcgatcttca aagtaacctt tcttctcctg gccgacagtc 360 cggggaatgc ggatgctggc actgcgattg gcgacaccag cagaaaagtc gttgatgttg 420 gacgtttcgt ggaacccagt cagacgacgg gcattgtcca ggcccccctt gggatcgtag 480 gctcgaatgt ggtaccggtg ccgcttgctt agtttctcga tggcctcctc gatgtgcttc 540 agaccattct cctcccgcat ggccttggtg ctaaagttgg tatggcagcc tgcaccattc 600 cagttcccag gaatgggctt ggggtcaaag gttgctatta ccccaaagtc ctcacatact 660 cgatgcaaga tgaaacgggc cacccagaga tgatctccca tgcggattcc ttcacagggt 720 cctatttgga actcccactg ggcaggcatg acctcagcat ttgttcctgt aatcttgacc 780 ccagcataca agcaggcgcg gtagtgagcc tccacgatat ccctgccata ggctttgtct 840 gcgcccacac cacagtaata cggaccttgg ggcccaggaa agccattgga aggccaacca 900 aaagggtgcc catctgttcc catcagagta tactcctgtt ccattccaaa ccaggggtgc 960 tggttgctca ccatgtccat tatccgttta cacgagtgcc ttaaatttgt ctctgcaggc 1020 ttccggttgt acttgaaaac ttcacagaac accagcttgt tgggatctct gcggaagggg 1080 tcccgaaaca tggcaacagg gctgagatac atgtcactgt tggagccctc agactgaaag 1140 gtactagagc catcaaaatt ccactcaggt aactcttcta cacacttggg ctcacagtcc 1200 agggtgcggg ttttgcagcg cagtccttct ccagtaccat caacccagat atacatggct 1260 tggactttct caccctgggg caggcacaag tacatttgct tgatgttttt gttcaagtgg 1320 gaacttgctg aggtggccat ggtggcgacg tgcgctccgg aggcttgcag aatgcggaac 1380 accgcgcggg caggaacagg gcccacacta ccgccccaca ccccgcctcc cgcaccgccc 1440 cttcccggcc gctgctctca gaaagcgaag gagcaaagct gctattggcc gctgccccaa 1500 aggcctaccc gcttccattg ctcagcggtg ctgtccatct gcacgagact agtgagtcgt 1560 gctacttcca tttgtcacgt cctgcacgac gcgagctgcg gggcgggggg gaacttcctg 1620 actaggggag gagtagaagg tggcgcgaag gggccaccaa agaacggagc cggttggcgc 1680 ctaccggtgg atgtggaatg tgtgcgaggc cagaggccac ttgtgtagcg ccaagtgccc 1740 agcggggctg ctaaagcgca tgctccagac tgccttggga aaagcgcctc ccctacccgg 1800 tagagaaact tgatctgtcg ccgcaattca aacttcgtga ggctccggtg cccgtcagtg 1860 gaagacta 1868 <210> 352 <211> 1866 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 352 tagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 gaggctggga aggggtgggt ccgggggcgg gctcaggggc gggctcaggg gcggggcggg 420 cgcccgaagg tcctccggag gcccggcatt ctgcacgctt caaaagcgca cgtctgccgc 480 gctgttctcc tcttcctcat ctccgggcct ttcgtccgcc accatggcca cctcagcaag 540 ttcccacttg aacaaaaaca tcaagcaaat gtacctgtgc ctgccccagg gtgagaaagt 600 ccaagccatg tatatctggg ttgatggtac tggagaagga ctgcgctgca aaacccgcac 660 cctggactgt gagcccaagt gtgtagaaga gttacctgag tggaattttg atggctctag 720 tacctttcag tctgagggct ccaacagtga catgtatctc agccctgttg ccatgtttcg 780 ggaccccttc cgccgggagc ccaacaagct ggtgttctgt gaagttttca agtacaaccg 840 gaagcctgca gagacaaatt taaggcactc ctgtaaacgg ataatggaca tggtgagcaa 900 ccagcacccc tggtttggaa tggaacagga gtatactctg atgggaacag atgggcaccc 960 ttttggttgg ccttccaatg gctttcctgg gccccaaggt ccgtattact gtggtgtggg 1020 cgcagacaaa gcctatggca gggatatcgt ggaggctcac taccgcgcct gcttgtatgc 1080 tggggtcaag attacaggaa caaatgctga ggtcatgcct gcccagtggg agttccaaat 1140 aggaccctgt gaaggaatcc acatgggaga tcatctctgg gtggcccgtt tcatcttgca 1200 tcgagtatgt gaggactttg gggtaatagc aacctttgac cccaagccca ttcctgggaa 1260 ctggaatggt gcaggctgcc ataccaactt tagcaccaag gccatgcggg aggagaatgg 1320 tctgaagcac atcgaggagg ccatcgagaa actaagcaag cggcaccagt accacattcg 1380 agcctacgat cccaaggggg gcctggacaa tgcccgtcgt ctgactgggt tccacgaaac 1440 gtccaacatc aacgactttt ctgctggtgt cgccaatcgc agtgccagca tccgcattcc 1500 ccggactgtc ggccaggaga agaaaggtta ctttgaagat cgccgcccct ctgccaattg 1560 tgaccccttt gcagtgacag aagccatcgt ccgcacatgc cttctcaatg agactggcga 1620 cgagcccttc caatacaaaa actaatgact cgctttcttg ctgtccaatt tctattaaag 1680 gttcctttgt tccctaagtc caactactaa actgggggat attatgaagg gccttgagca 1740 tctggattct gcctaataaa aaacatttat tttcattgca atgatgtatt taaattattt 1800 ctgaatattt tactaaaaag ggaatgtggg aggtcagtgc atttaaaaca taaagaaaga 1860 agacac 1866 <210> 353 <211> 2785 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 353 aagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggccacctca gcaagttccc acttgaacaa aaacatcaag caaatgtact 720 tgtgcctgcc ccagggtgag aaagtccaag ccatgtatat ctgggttgat ggtactggag 780 aaggactgcg ctgcaaaacc cgcaccctgg actgtgagcc caagtgtgta gaagagttac 840 ctgagtggaa ttttgatggc tctagtacct ttcagtctga gggctccaac agtgacatgt 900 atctcagccc tgttgccatg tttcgggacc ccttccgcag agatcccaac aagctggtgt 960 tctgtgaagt tttcaagtac aaccggaagc ctgcagagac aaatttaagg cactcgtgta 1020 aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa caggagtata 1080 ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt cctgggcccc 1140 aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat atcgtggagg 1200 ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat gctgaggtca 1260 tgcctgccca gtgggagttc caaataggac cctgtgaagg aatccgcatg ggagatcatc 1320 tctgggtggc ccgtttcatc ttgcatcgag tatgtgagga ctttggggta atagcaacct 1380 ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc aactttagca 1440 ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc gagaaactaa 1500 gcaagcggca caggtaccac attcgagcct acgatcccaa ggggggcctg gacaatgccc 1560 gtcgtctgac tgggttccac gaaacgtcca acatcaacga cttttctgct ggtgtcgcca 1620 atcgcagtgc cagcatccgc attccccgga ctgtcggcca ggagaagaaa ggttactttg 1680 aagatcgccg cccctctgcc aattgtgacc cctttgcagt gacagaagcc atcgtccgca 1740 catgccttct caatgagact ggcgacgagc ccttccaata caaaaactaa ttagactttg 1800 agtgatcttg agcctttcct agttcatccc accccgcccc agagagatct ttgtgaagga 1860 accttacttc tgtggtgtga cataattgga caaactacct acagagattt aaagctctaa 1920 ggtaaatata aaatttttaa gtgtataatg tgttaaacta ctgattctaa ttgtttgtgt 1980 attttagatt ccaacctatg gaactgatga atgggagcag tggtggaatg cctttaatga 2040 ggaaaacctg ttttgctcag aagaaatgcc atctagtgat gatgaggcta ctgctgactc 2100 tcaacattct actcctccaa aaaagaagag aaaggtagaa gatcccaagg actttccttc 2160 agaattgcta agttttttga gtcatgctgt gtttagtaat agaactcttg cttgctttgc 2220 tatttacacc acaaaggaaa aagctgcact gctatacaag aaaattatgg aaaaatattc 2280 tgtaaccttt ataagtaggc ataacagtta taatcataac atactgtttt ttcttactcc 2340 acacaggcat agagtgtctg ctattaataa ctatgctcaa aaattgtgta cctttagctt 2400 tttaatttgt aaaggggtta ataaggaata tttgatgtat agtgccttga ctagagatca 2460 taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 2520 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 2580 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 2640 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggatctagc 2700 ttcgtgtcaa ggacggtgac tgcagtgaat aataaaatgt gtgtttgtcc gaaatacgcg 2760 ttttgagatt tctcgaggaa gacat 2785 <210> 354 <211> 1971 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 354 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg acacaagaca 120 ggcttgcgcc accatggttg agaataccac tttatcccgc gtcagggaga ggcagtgcgt 180 aaaaagacgc ggaaccatgt gaaatactgg tttttagtgc gccagatctc tataatctcg 240 cgcaacctat tttcccctcg aacacttttt aagccgtaga taaacaggct gggacacttc 300 acatggccac ctcagcaagt tcccacttga acaaaaacat caagcaaatg tacctgtgcc 360 tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtact ggagaaggac 420 tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag ttacctgagt 480 ggaattttga tggctctagt acctttcagt ctgagggctc caacagtgac atgtatctca 540 gccctgttgc catgtttcgg gaccccttcc gccgggagcc caacaagctg gtgttctgtg 600 aagttttcaa gtacaaccgg aagcctgcag agacaaattt aaggcactcc tgtaaacgga 660 taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag tatactctga 720 tgggaacaga tgggcaccct tttggttggc cttccaatgg ctttcctggg ccccaaggtc 780 cgtattactg tggtgtgggc gcagacaaag cctatggcag ggatatcgtg gaggctcact 840 accgcgcctg cttgtatgct ggggtcaaga ttacaggaac aaatgctgag gtcatgcctg 900 cccagtggga gttccaaata ggaccctgtg aaggaatcca catgggagat catctctggg 960 tggcccgttt catcttgcat cgagtatgtg aggactttgg ggtaatagca acctttgacc 1020 ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt agcaccaagg 1080 ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc catcgagaaa ctaagcaagc 1140 ggcaccagta ccacattcga gcctacgatc ccaagggggg cctggacaat gcccgtcgtc 1200 tgactgggtt ccacgaaacg tccaacatca acgacttttc tgctggtgtc gccaatcgca 1260 gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac tttgaagatc 1320 gccgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc cgcacatgcc 1380 ttctcaatga gactggcgac gagcccttcc aatacaaaaa ctaataatta gactttgagt 1440 gatcttgagc ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc 1500 ttacttctgt ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt 1560 aaatataaaa tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt 1620 ttagattcca acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga 1680 aaacctgttt tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca 1740 acattctact cctctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct 1800 aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta 1860 ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta 1920 aaaagggaat gtgggaggtc agtgcattta aaacataaag aaagaagaca c 1971 <210> 355 <211> 2034 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 355 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg acacaagaca 120 ggcttgcgcc accatggttg agaataccac tttatcccgc gtcagggaga ggcagtgcgt 180 aaaaagacgc ggaaccatgt gaaatactgg tttttagtgc gccagatctc tataatctcg 240 cgcaacctat tttcccctcg aacacttttt aagccgtaga taaacaggct gggacacttc 300 acatggccac ctcagcaagt tcccacttga acaaaaacat caagcaaatg tacctgtgcc 360 tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtact ggagaaggac 420 tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag ttacctgagt 480 ggaattttga tggctctagt acctttcagt ctgagggctc caacagtgac atgtatctca 540 gccctgttgc catgtttcgg gaccccttcc gccgggagcc caacaagctg gtgttctgtg 600 aagttttcaa gtacaaccgg aagcctgcag agacaaattt aaggcactcc tgtaaacgga 660 taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag tatactctga 720 tgggaacaga tgggcaccct tttggttggc cttccaatgg ctttcctggg ccccaaggtc 780 cgtattactg tggtgtgggc gcagacaaag cctatggcag ggatatcgtg gaggctcact 840 accgcgcctg cttgtatgct ggggtcaaga ttacaggaac aaatgctgag gtcatgcctg 900 cccagtggga gttccaaata ggaccctgtg aaggaatcca catgggagat catctctggg 960 tggcccgttt catcttgcat cgagtatgtg aggactttgg ggtaatagca acctttgacc 1020 ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt agcaccaagg 1080 ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc catcgagaaa ctaagcaagc 1140 ggcaccagta ccacattcga gcctacgatc ccaagggggg cctggacaat gcccgtcgtc 1200 tgactgggtt ccacgaaacg tccaacatca acgacttttc tgctggtgtc gccaatcgca 1260 gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac tttgaagatc 1320 gccgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc cgcacatgcc 1380 ttctcaatga gactggcgac gagcccttcc aatacaaaaa ctggatccgc tcagacatga 1440 taagatacat tgatgagttt ggacaaacca caactagaat gcagtgataa ttagactttg 1500 agtgatcttg agcctttcct agttcatccc accccgcccc agagagatct ttgtgaagga 1560 accttacttc tgtggtgtga cataattgga caaactacct acagagattt aaagctctaa 1620 ggtaaatata aaatttttaa gtgtataatg tgttaaacta ctgattctaa ttgtttgtgt 1680 attttagatt ccaacctatg gaactgatga atgggagcag tggtggaatg cctttaatga 1740 ggaaaacctg ttttgctcag aagaaatgcc atctagtgat gatgaggcta ctgctgactc 1800 tcaacattct actcctctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc 1860 cctaagtcca actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc 1920 ctaataaaaa acatttattt tcattgcaat gatgtattta aattatttct gaatatttta 1980 ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata aagaaagaag acac 2034 <210> 356 <211> 2337 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 356 tagtcttctt ggcgaaaaca cgcagatgca gtcggggcgg cgcggtccca ggtccacttc 60 gcatattaag gtgacgcgtg tggcctcgaa cacagagcga ctctgcaggg acacaagaca 120 ggcttgcgcc accatggttg agaataccac tttatcccgc gtcagggaga ggcagtgcgt 180 aaaaagacgc ggaaccatgt gaaatactgg tttttagtgc gccagatctc tataatctcg 240 cgcaacctat tttcccctcg aacacttttt aagccgtaga taaacaggct gggacacttc 300 acatggccac ctcagcaagt tcccacttga acaaaggcat caagcaaatg tacatgtccc 360 tgccccaggg tgagaaaatc caagccatgt atatctgggt tgatggtacc ggagaaggac 420 tgcgctgcaa gacccgtacc ctggactgtg accccaagtg tgtggaagag ttacctgagt 480 ggaactttga tggctctagt acctttcagt ctgaaggctc caacagcgac atgtacctcc 540 atcctgttgc catgtttcgg gaccccttcc gcaaagaccc caacaagctg gtgctatgtg 600 aagttttcaa gtataaccgg aagcctgcag aaaccaactt gaggcacatc tgtaaacgga 660 taatggacat ggtgagcaac cagcacccct ggtttggaat ggagcaggaa tatactctta 720 tgggaacaga cggccaccca tttggttggc cttccaatgg cttccctgga ccccaaggcc 780 cgtattactg cggtgtggga gcagacaagg cctacggcag ggacatcgtg gaggctcact 840 accgggcctg cttgtatgct ggagtcaaga tcacggggac aaatgcggag gttatgcctg 900 cccagtggga attccagata ggaccctgtg agggaatccg aatgggagat catctttgga 960 tagcccgttt tatcttgcat cgggtgtgcg aagattttgg ggtgatagca acctttgacc 1020 ccaagcccat tccagggaac tggaatggtg caggctgcca taccaacttc agcaccaagg 1080 ccatgcggga ggagaatggt ctgaagtgca ttgaggaggc cattgacaaa ctgagcaaga 1140 ggcaccagta ccacatccgc gcctacgatc ccaagggggg cctggacaac gcccggcgtc 1200 tgactggatt ccacgaaacc tccaacatca acgacttttc tgccggtgtt gccaaccgct 1260 ccgccagtat ccgcattccc cggactgtcg gccaggagaa gaagggctac tttgaggacc 1320 gtcggccttc tgccaattgt gacccctatg cggtgacaga agccatcgtc cgcacgtgtc 1380 tcctcaacga aacaggcgac gaacccttcc aatacaagaa ctaataatta gactttgagt 1440 gatcttgagc ctttcctagt tcatcccacc ccgccccaga gagatctttg tgaaggaacc 1500 ttacttctgt ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt 1560 aaatataaaa tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt 1620 ttagattcca acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga 1680 aaacctgttt tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca 1740 acattctact cctccaaaaa agaagagaaa ggtagaagat cccaaggact ttccttcaga 1800 attgctaagt tttttgagtc atgctgtgtt tagtaataga actcttgctt gctttgctat 1860 ttacaccaca aaggaaaaag ctgcactgct atacaagaaa attatggaaa aatattctgt 1920 aacctttata agtaggcata acagttataa tcataacata ctgttttttc ttactccaca 1980 caggcataga gtgtctgcta ttaataacta tgctcaaaaa ttgtgtacct ttagcttttt 2040 aatttgtaaa ggggttaata aggaatattt gatgtatagt gccttgacta gagatcataa 2100 tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc 2160 tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata 2220 atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 2280 attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg aagacac 2337 <210> 357 <211> 1586 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 357 accggtcagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg tgtccccgga 60 agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca gcgtcttgtc 120 attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt 180 aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg gccacctcag 240 caagttccca cttgaacaaa aacatcaagc aaatgtactt gtgcctgccc cagggtgaga 300 aagtccaagc catgtatatc tgggttgatg gtactggaga aggactgcgc tgcaaaaccc 360 gcaccctgga ctgtgagccc aagtgtgtag aagagttacc tgagtggaat tttgatggct 420 ctagtacctt tcagtctgag ggctccaaca gtgacatgta tctcagccct gttgccatgt 480 ttcgggaccc cttccgcaga gatcccaaca agctggtgtt ctgtgaagtt ttcaagtaca 540 accggaagcc tgcagagaca aatttaaggc actcgtgtaa acggataatg gacatggtga 600 gcaaccagca cccctggttt ggaatggaac aggagtatac tctgatggga acagatgggc 660 acccttttgg ttggccttcc aatggctttc ctgggcccca aggtccgtat tactgtggtg 720 tgggcgcaga caaagcctat ggcagggata tcgtggaggc tcactaccgc gcctgcttgt 780 atgctggggt caagattaca ggaacaaatg ctgaggtcat gcctgcccag tgggagttcc 840 aaataggacc ctgtgaagga atccgcatgg gagatcatct ctgggtggcc cgtttcatct 900 tgcatcgagt atgtgaggac tttggggtaa tagcaacctt tgaccccaag cccattcctg 960 ggaactggaa tggtgcaggc tgccatacca actttagcac caaggccatg cgggaggaga 1020 atggtctgaa gcacatcgag gaggccatcg agaaactaag caagcggcac aggtaccaca 1080 ttcgagccta cgatcccaag gggggcctgg acaatgcccg tcgtctgact gggttccacg 1140 aaacgtccaa catcaacgac ttttctgctg gtgtcgccaa tcgcagtgcc agcatccgca 1200 ttccccggac tgtcggccag gagaagaaag gttactttga agatcgccgc ccctctgcca 1260 attgtgaccc ctttgcagtg acagaagcca tcgtccgcac atgccttctc aatgagactg 1320 gcgacgagcc cttccaatac aaaaactgga tccgctcaga catgataaga tacattgatg 1380 agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg 1440 atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt 1500 gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa 1560 acctctacaa atgtggtaat ttaaat 1586 <210> 358 <211> 1592 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 358 gtaagcaggt taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 60 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 120 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 180 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgagcggatc 240 cagtttttgt attggaaggg ctcgtcgcca gtctcattga gaaggcatgt gcggacgatg 300 gcttctgtca ctgcaaaggg gtcacaattg gcagaggggc ggcgatcttc aaagtaacct 360 ttcttctcct ggccgacagt ccggggaatg cggatgctgg cactgcgatt ggcgacacca 420 gcagaaaagt cgttgatgtt ggacgtttcg tggaacccag tcagacgacg ggcattgtcc 480 aggcccccct tgggatcgta ggctcgaatg tggtacctgt gccgcttgct tagtttctcg 540 atggcctcct cgatgtgctt cagaccattc tcctcccgca tggccttggt gctaaagttg 600 gtatggcagc ctgcaccatt ccagttccca ggaatgggct tggggtcaaa ggttgctatt 660 accccaaagt cctcacatac tcgatgcaag atgaaacggg ccacccagag atgatctccc 720 atgcggattc cttcacaggg tcctatttgg aactcccact gggcaggcat gacctcagca 780 tttgttcctg taatcttgac cccagcatac aagcaggcgc ggtagtgagc ctccacgata 840 tccctgccat aggctttgtc tgcgcccaca ccacagtaat acggaccttg gggcccagga 900 aagccattgg aaggccaacc aaaagggtgc ccatctgttc ccatcagagt atactcctgt 960 tccattccaa accaggggtg ctggttgctc accatgtcca ttatccgttt acacgagtgc 1020 cttaaatttg tctctgcagg cttccggttg tacttgaaaa cttcacagaa caccagcttg 1080 ttgggatctc tgcggaaggg gtcccgaaac atggcaacag ggctgagata catgtcactg 1140 ttggagccct cagactgaaa ggtactagag ccatcaaaat tccactcagg taactcttct 1200 acacacttgg gctcacagtc cagggtgcgg gttttgcagc gcagtccttc tccagtacca 1260 tcaacccaga tatacatggc ttggactttc tcaccctggg gcaggcacaa gtacatttgc 1320 ttgatgtttt tgttcaagtg ggaacttgct gaggtggcca tgccaccctg cagagtcgct 1380 ctgtgttcga ggccacacgc gtcaccttaa tatgcgaagt ggacctggga ccgcgccgcc 1440 ccgactgcat ctgcgtgttt tcgccaatga caagacgctg ggcggggttt gtgtcatcat 1500 agaactaaag acatgcaaat atatttcttc cggggacacc gccagcaaac gcgagcaacg 1560 ggccacgggg atgaagcagc tgacctgcta ta 1592 <210> 359 <211> 2030 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 359 aagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggccacctca gcaagttccc acttgaacaa aaacatcaag caaatgtact 720 tgtgcctgcc ccagggtgag aaagtccaag ccatgtatat ctgggttgat ggtactggag 780 aaggactgcg ctgcaaaacc cgcaccctgg actgtgagcc caagtgtgta gaagagttac 840 ctgagtggaa ttttgatggc tctagtacct ttcagtctga gggctccaac agtgacatgt 900 atctcagccc tgttgccatg tttcgggacc ccttccgcag agatcccaac aagctggtgt 960 tctgtgaagt tttcaagtac aaccggaagc ctgcagagac aaatttaagg cactcgtgta 1020 aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa caggagtata 1080 ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt cctgggcccc 1140 aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat atcgtggagg 1200 ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat gctgaggtca 1260 tgcctgccca gtgggagttc caaataggac cctgtgaagg aatccgcatg ggagatcatc 1320 tctgggtggc ccgtttcatc ttgcatcgag tatgtgagga ctttggggta atagcaacct 1380 ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc aactttagca 1440 ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc gagaaactaa 1500 gcaagcggca caggtaccac attcgagcct acgatcccaa ggggggcctg gacaatgccc 1560 gtcgtctgac tgggttccac gaaacgtcca acatcaacga cttttctgct ggtgtcgcca 1620 atcgcagtgc cagcatccgc attccccgga ctgtcggcca ggagaagaaa ggttactttg 1680 aagatcgccg cccctctgcc aattgtgacc cctttgcagt gacagaagcc atcgtccgca 1740 catgccttct caatgagact ggcgacgagc ccttccaata caaaaactaa tggatccgct 1800 cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa 1860 aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca 1920 ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt 1980 gggaggtttt ttaaagcaag taaaacctct acaaatgtgg tagaagacaa 2030 <210> 360 <211> 1875 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 360 gtgtcttctt tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtc attagttttt gtattggaag 240 ggctcgtcgc cagtctcatt gagaaggcat gtgcggacga tggcttctgt cactgcaaag 300 gggtcacaat tggcagaggg gcggcgatct tcaaagtaac ctttcttctc ctggccgaca 360 gtccggggaa tgcggatgct ggcactgcga ttggcgacac cagcagaaaa gtcgttgatg 420 ttggacgttt cgtggaaccc agtcagacga cgggcattgt ccaggccccc cttgggatcg 480 taggctcgaa tgtggtactg gtgccgcttg cttagtttct cgatggcctc ctcgatgtgc 540 ttcagaccat tctcctcccg catggccttg gtgctaaagt tggtatggca gcctgcacca 600 ttccagttcc caggaatggg cttggggtca aaggttgcta ttaccccaaa gtcctcacat 660 actcgatgca agatgaaacg ggccacccag agatgatctc ccatgtggat tccttcacag 720 ggtcctattt ggaactccca ctgggcaggc atgacctcag catttgttcc tgtaatcttg 780 accccagcat acaagcaggc gcggtagtga gcctccacga tatccctgcc ataggctttg 840 tctgcgccca caccacagta atacggacct tggggcccag gaaagccatt ggaaggccaa 900 ccaaaagggt gcccatctgt tcccatcaga gtatactcct gttccattcc aaaccagggg 960 tgctggttgc tcaccatgtc cattatccgt ttacaggagt gccttaaatt tgtctctgca 1020 ggcttccggt tgtacttgaa aacttcacag aacaccagct tgttgggctc ccggcggaag 1080 gggtcccgaa acatggcaac agggctgaga tacatgtcac tgttggagcc ctcagactga 1140 aaggtactag agccatcaaa attccactca ggtaactctt ctacacactt gggctcacag 1200 tccagggtgc gggttttgca gcgcagtcct tctccagtac catcaaccca gatatacatg 1260 gcttggactt tctcaccctg gggcaggcac aggtacattt gcttgatgtt tttgttcaag 1320 tgggaacttg ctgaggtggc catggtggcg gacgaaaggc ccggagatga ggaagaggag 1380 aacagcgcgg cagacgtgcg cttttgaagc gtgcagaatg ccgggcctcc ggaggacctt 1440 cgggcgcccg ccccgcccct gagcccagaa agcgaaggag caaagctgct attggccgct 1500 gccccaaagg cctacccgct tccattgctc agcggtgctg tccatctgca cgagactagt 1560 gagtcgtgct acttccattt gtcacgtcct gcacgacgcg agctgcgggg cgggggggaa 1620 cttcctgact aggggaggag tagaaggtgg cgcgaagggg ccaccaaaga acggagccgg 1680 ttggcgccta ccggtggatg tggaatgtgt gcgaggccag aggccacttg tgtagcgcca 1740 agtgcccagc ggggctgcta aagcgcatgc tccagactgc cttgggaaaa gcgcctcccc 1800 tacccggtag agaaacttga tctgtcgccg caattcaaac ttcgtgaggc tccggtgccc 1860 gtcagtggaa gacta 1875 <210> 361 <211> 1926 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 361 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcatcagttt ttgtattgga 240 agggctcgtc gccagtctca ttgagaaggc atgtgcggac gatggcttct gtcactgcaa 300 aggggtcaca attggcagag gggcggcggt cttcaaagta acctttcttc tcctggccga 360 cagtccgggg aatgcggatg ctggcactgc gattggcgac accagcagaa aagtcgttga 420 tgttggacgt ttcgtggaac ccagtcagac gacgggcatt gtccaggccc cccttgggat 480 cgtaggctcg aatgtggtac cggtgccgct tgcttagttt ctcgatggcc tcctcgatgt 540 gcttcagacc attctcctcc cgcatggcct tggtgctaaa gttggtatgg cagcctgcac 600 cattccagtt cccaggaatg ggcttggggt caaaggttgc tattacccca aagtcttcac 660 atactcgatg caagatgaaa cgggccaccc agagatgatc tcccatgcgg attccttcac 720 agggtcctat ttggaactcc cactgggcag gcatgacctc agcatttgtt cctgtaatct 780 tgaccccagc atacaagcag gcgcggtagt gagcctccac gatatccctg ccataggctt 840 tgtctgcgcc cacaccacag taatacggac cttggggccc aggaaagcca ttggaaggcc 900 aaccaaaagg gtgcccatct gttcccatca gagtatactc ctgttccatt ccaaaccagg 960 ggtgctggtt gctcaccatg tccattatcc gtttacacga gtgccttaaa tttgtctctg 1020 caggcttccg gttgtacttg aaaacttcac agaacaccag cttgttggga tctctgcgga 1080 aggggtcccg aaacatggca acagggctga gatacatgtc actgttggag ccctcagact 1140 gaaaggtact agagccatca aaattccact caggtaactc ttctacacac ttgggctcac 1200 agtccagggt gcgggttttg cagcgcagtc cttctccagt accatcaacc cagatataca 1260 tggcttggac tttctcaccc tggggcaggc acaagtacat ttgcttgatg tttttgttca 1320 agtgggaact tgctgaggtg gccatggtgg cggacgaaag gcccggagat gaggaagagg 1380 agaacagcgc ggcagacgtg cgcttttgaa gcgtgcagaa tgccgggcct ccggaggacc 1440 ttcgggcgcc cgccccgccc ctgagcccgc ccctgagccc gcccccggac ccaccccttc 1500 ccagcctctg agcccagaaa gcgaaggagc aaagctgcta ttggccgctg ccccaaaggc 1560 ctacccgctt ccattgctca gcggtgctgt ccatctgcac gagactagtg agtcgtgcta 1620 cttccatttg tcacgtcctg cacgacgcga gctgcggggc gggggggaac ttcctgacta 1680 ggggaggagt agaaggtggc gcgaaggggc caccaaagaa cggagccggt tggcgcctac 1740 cggtggatgt ggaatgtgtg cgaggccaga ggccacttgt gtagcgccaa gtgcccagcg 1800 gggctgctaa agcgcatgct ccagactgcc ttgggaaaag cgcctcccct acccggtaga 1860 gaaacttgat ctgtcgccgc aattcaaact tcgtgaggct ccggtgcccg tcagtgacct 1920 gctata 1926 <210> 362 <211> 1926 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 362 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcatcagttt ttgtattgga 240 agggctcgtc gccagtctca ttgagaaggc atgtgcggac gatggcttct gtcactgcaa 300 aggggtcaca attggcagag gggcggcgat cttcaaagta acctttcttc tcctggccga 360 cagtccgggg aatgcggatg ctggcactgc gattggcgac accagcagaa aagtcgttga 420 tgttggacgt ttcgtggaac ccagtcagac gacgggcatt gtccaggccc cccttgggat 480 cgtaggctcg aatgtggtac cggtgccgct tgcttagttt ctcgatggcc tcctcgatgt 540 gcttcagacc attctcctcc cgcatggcct tggtgctaaa gttggtatgg cagcctgcac 600 cattccagtt cccaggaatg ggcttggggt caaaggttgc tattacccca aagtcctcac 660 atactcgatg caagatgaaa cgggccaccc agagatgatc tcccatgcgg attccttcac 720 agggtcctat ttggaactcc cactgggcag gcatgacctc agcatttgtt cctgtaatct 780 tgaccccagc atacaagcag gcgcggtagt gagcctccac gatatccctg ccataggctt 840 tgtctgcgcc cacaccacag taatacggac cttggggccc aggaaagcca ttggaaggcc 900 aaccaaaagg gtgcccatct gttcccatca gagtatactc ctgttccatt ccaaaccagg 960 ggtgctggtt gctcaccatg tccattatcc gtttacacga gtgccttaaa tttgtctctg 1020 caggcttccg gttgtacttg aaaacttcac agaacaccag cttgttggga tctctgcgga 1080 aggggtcccg aaacatggca acagggctga gatacatgtc actgttggag ccctcagact 1140 gaaaggtact agagccatca aaattccact caggtaactc ttctacacac ttgggctcac 1200 agtccagggt gcgggttttg cagcgcagtc cttctccagt accatcaacc cagatataca 1260 tggcttggac tttctcaccc tggggcaggc acaagtacat ttgcttgatg tttttgttca 1320 agtgggaact tgctgaggtg gccatggtgg cggacgaaag gcccggagat gaggaagagg 1380 agaacagcgc ggcagacgtg cgcttttgaa gcgtgcagaa tgccgggcct ccggaggacc 1440 ttcgggcgcc cgccccgccc ctgagcccgc ccctgagccc gcccccggac ccaccccttc 1500 ccagcctctg agcccagaaa gcgaaggagc aaagctgcta ttggccgctg ccccaaaggc 1560 ctacccgctt ccattgctca gcggtgctgt ccatctgcac gagactagtg agtcgtgcta 1620 cttccatttg tcacgtcctg cacgacgcga gctgcggggc gggggggaac ttcctgacta 1680 ggggaggagt agaaggtggc gcgaaggggc caccaaagaa cggagccggt tggcgcctac 1740 cggtggatgt ggaatgtgtg cgaggccaga ggccacttgt gtagcgccaa gtgcccagcg 1800 gggctgctaa agcgcatgct ccagactgcc ttgggaaaag cgcctcccct acccggtaga 1860 gaaacttgat ctgtcgccgc aattcaaact tcgtgaggct ccggtgcccg tcagtgacct 1920 gctata 1926 <210> 363 <211> 678 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 363 agtgacatgt atctcagccc tgttgccatg tttcgggacc ccttccgccg ggagcccaac 60 aagctggtgt tctgtgaagt tttcaagtac aaccggaagc ctgcagagac aaatttaagg 120 cactcctgta aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa 180 caggagtata ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt 240 cctgggcccc aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat 300 atcgtggagg ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat 360 gctgaggtca tgcctgccca gtgggagttc caaataggac cctgtgaagg aatccacatg 420 ggagatcatc tctgggtggc ccgtttcatc ttgcatcgag tatgtgagga ctttggggta 480 atagcaacct ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc 540 aactttagca ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc 600 gagaaactaa gcaagcggca ccagtaccac attcgagcct acgatcccaa ggggggcctg 660 gacaatgccc gtcgtctg 678 <210> 364 <211> 1535 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 364 aagtcttctt aattaatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatggc cacctcagca 180 agttcccact tgaacaaaaa catcaagcaa atgtacttgt gcctgcccca gggtgagaaa 240 gtccaagcca tgtatatctg ggttgatggt actggagaag gactgcgctg caaaacccgc 300 accctggact gtgagcccaa gtgtgtagaa gagttacctg agtggaattt tgatggctct 360 agtacctttc agtctgaggg ctccaacagt gacatgtatc tcagccctgt tgccatgttt 420 cgggacccct tccgcagaga tcccaacaag ctggtgttct gtgaagtttt caagtacaac 480 cggaagcctg cagagacaaa tttaaggcac tcgtgtaaac ggataatgga catggtgagc 540 aaccagcacc cctggtttgg aatggaacag gagtatactc tgatgggaac agatgggcac 600 ccttttggtt ggccttccaa tggctttcct gggccccaag gtccgtatta ctgtggtgtg 660 ggcgcagaca aagcctatgg cagggatatc gtggaggctc actaccgcgc ctgcttgtat 720 gctggggtca agattacagg aacaaatgct gaggtcatgc ctgcccagtg ggagttccaa 780 ataggaccct gtgaaggaat ccgcatggga gatcatctct gggtggcccg tttcatcttg 840 catcgagtat gtgaggactt tggggtaata gcaacctttg accccaagcc cattcctggg 900 aactggaatg gtgcaggctg ccataccaac tttagcacca aggccatgcg ggaggagaat 960 ggtctgaagc acatcgagga ggccatcgag aaactaagca agcggcacag gtaccacatt 1020 cgagcctacg atcccaaggg gggcctggac aatgcccgtc gtctgactgg gttccacgaa 1080 acgtccaaca tcaacgactt ttctgctggt gtcgccaatc gcagtgccag catccgcatt 1140 ccccggactg tcggccagga gaagaaaggt tactttgaag atcgccgccc ctctgccaat 1200 tgtgacccct ttgcagtgac agaagccatc gtccgcacat gccttctcaa tgagactggc 1260 gacgagccct tccaatacaa aaactaatgg atccgctcag acatgataag atacattgat 1320 gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt 1380 gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat 1440 tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa 1500 aacctctaca aatgtggtag gcgcgccgaa gacaa 1535 <210> 365 <211> 2449 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 365 accggtaagt ttccagagct ttcgaggaag gtttcttcaa ctcaaattca tccgcctgat 60 aattttctta tattttccta aagaaggaag agaagcgcat agaggagaag ggaaataatt 120 ttttaggagc ctttcttacg gctatgagga atttggggct cagttgaaaa gcctaaactg 180 cctctcggga ggttgggcgc ggcgaactac tttcagcggc gcacgcagac ggcgtctacg 240 tgaggggtga taagtgacgc aacactcgtt gcataaattt gcgctccgcc agcccggagc 300 atttaggggc ggttggcttt gttgggtgag cttgtttgtg tccctgtggg tggacgtggt 360 tggtgattgg caggatcctg gtatccgcta caggtactgg cccacagccg taaagagctg 420 cgggggcgtg agagggggga atgggtgagg tcaagctgga ggcttcttgg ggttgggtgg 480 gccgctgagg ggaggggagg gcgaggtgac gcgacacccg gcctttctgg gagagtgggc 540 cttgttgacc taaggggggc gagggcagtt ggcacgcgca cgcgccgaca gaaactaaca 600 gacattaacc aacagcgatt ccgtcgcgtt tacttgggag gaaggcggaa aagaggtagt 660 ttgtgtggct tctggaaacc ctaaatttgg aatcccagta tgagaatggt gtcccttctt 720 gtgtttcaat gggattttta cttcgcgagt cttgtgggtt tggttttgtt ttcagtttgc 780 ctaacaccgt gcttaggttt gaggcagatt ggagttcggt cgggggagtt tgaatatccg 840 gaacagttag tggggaaagc tgtggacgct tggtaagaga gcgctctgga ttttccgctg 900 ttgacgttga aaccttgaat gacgaatttc gtattaagtg acttagcctt gtaaaattga 960 ggggaggctt gcggaatatt aacgtattta aggcattttg aaggaatagt tgctaatttt 1020 gaagaatatt aggtgtaaaa gcaagaaata caatgatcct gaggtgacac gcttatgttt 1080 tacttttaaa ctaggtcaaa atggccacct cagcaagttc ccacttgaac aaaaacatca 1140 agcaaatgta cttgtgcctg ccccagggtg agaaagtcca agccatgtat atctgggttg 1200 atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg 1260 tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct gagggctcca 1320 acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc agagatccca 1380 acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag acaaatttaa 1440 ggcactcgtg taaacggata atggacatgg tgagcaacca gcacccctgg tttggaatgg 1500 aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct tccaatggct 1560 ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc tatggcaggg 1620 atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt acaggaacaa 1680 atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa ggaatccgca 1740 tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgag gactttgggg 1800 taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca ggctgccata 1860 ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc gaggaggcca 1920 tcgagaaact aagcaagcgg cacaggtacc acattcgagc ctacgatccc aaggggggcc 1980 tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac gacttttctg 2040 ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc caggagaaga 2100 aaggttactt tgaagatcgc cgcccctctg ccaattgtga cccctttgca gtgacagaag 2160 ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa tacaaaaacc 2220 agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa 2280 atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa 2340 taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg 2400 ggaggttttt taaagcaagt aaaacctcta caaatgtggt aatttaaat 2449 <210> 366 <211> 2455 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 366 gtaagcaggt taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc 60 ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt 120 ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac 180 tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggtttttgt 240 attggaaggg ctcgtcgcca gtctcattga gaaggcatgt gcggacgatg gcttctgtca 300 ctgcaaaggg gtcacaattg gcagaggggc ggcgatcttc aaagtaacct ttcttctcct 360 ggccgacagt ccggggaatg cggatgctgg cactgcgatt ggcgacacca gcagaaaagt 420 cgttgatgtt ggacgtttcg tggaacccag tcagacgacg ggcattgtcc aggcccccct 480 tgggatcgta ggctcgaatg tggtacctgt gccgcttgct tagtttctcg atggcctcct 540 cgatgtgctt cagaccattc tcctcccgca tggccttggt gctaaagttg gtatggcagc 600 ctgcaccatt ccagttccca ggaatgggct tggggtcaaa ggttgctatt accccaaagt 660 cctcacatac tcgatgcaag atgaaacggg ccacccagag atgatctccc atgcggattc 720 cttcacaggg tcctatttgg aactcccact gggcaggcat gacctcagca tttgttcctg 780 taatcttgac cccagcatac aagcaggcgc ggtagtgagc ctccacgata tccctgccat 840 aggctttgtc tgcgcccaca ccacagtaat acggaccttg gggcccagga aagccattgg 900 aaggccaacc aaaagggtgc ccatctgttc ccatcagagt atactcctgt tccattccaa 960 accaggggtg ctggttgctc accatgtcca ttatccgttt acacgagtgc cttaaatttg 1020 tctctgcagg cttccggttg tacttgaaaa cttcacagaa caccagcttg ttgggatctc 1080 tgcggaaggg gtcccgaaac atggcaacag ggctgagata catgtcactg ttggagccct 1140 cagactgaaa ggtactagag ccatcaaaat tccactcagg taactcttct acacacttgg 1200 gctcacagtc cagggtgcgg gttttgcagc gcagtccttc tccagtacca tcaacccaga 1260 tatacatggc ttggactttc tcaccctggg gcaggcacaa gtacatttgc ttgatgtttt 1320 tgttcaagtg ggaacttgct gaggtggcca ttttgaccta gtttaaaagt aaaacataag 1380 cgtgtcacct caggatcatt gtatttcttg cttttacacc taatattctt caaaattagc 1440 aactattcct tcaaaatgcc ttaaatacgt taatattccg caagcctccc ctcaatttta 1500 caaggctaag tcacttaata cgaaattcgt cattcaaggt ttcaacgtca acagcggaaa 1560 atccagagcg ctctcttacc aagcgtccac agctttcccc actaactgtt ccggatattc 1620 aaactccccc gaccgaactc caatctgcct caaacctaag cacggtgtta ggcaaactga 1680 aaacaaaacc aaacccacaa gactcgcgaa gtaaaaatcc cattgaaaca caagaaggga 1740 caccattctc atactgggat tccaaattta gggtttccag aagccacaca aactacctct 1800 tttccgcctt cctcccaagt aaacgcgacg gaatcgctgt tggttaatgt ctgttagttt 1860 ctgtcggcgc gtgcgcgtgc caactgccct cgcccccctt aggtcaacaa ggcccactct 1920 cccagaaagg ccgggtgtcg cgtcacctcg ccctcccctc ccctcagcgg cccacccaac 1980 cccaagaagc ctccagcttg acctcaccca ttcccccctc tcacgccccc gcagctcttt 2040 acggctgtgg gccagtacct gtagcggata ccaggatcct gccaatcacc aaccacgtcc 2100 acccacaggg acacaaacaa gctcacccaa caaagccaac cgcccctaaa tgctccgggc 2160 tggcggagcg caaatttatg caacgagtgt tgcgtcactt atcacccctc acgtagacgc 2220 cgtctgcgtg cgccgctgaa agtagttcgc cgcgcccaac ctcccgagag gcagtttagg 2280 cttttcaact gagccccaaa ttcctcatag ccgtaagaaa ggctcctaaa aaattatttc 2340 ccttctcctc tatgcgcttc tcttccttct ttaggaaaat ataagaaaat tatcaggcgg 2400 atgaatttga gttgaagaaa ccttcctcga aagctctgga aacttacctg ctata 2455 <210> 367 <211> 2206 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 367 aagtcttctt aattaatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatggc cacctcagca 180 agttcccact tgaacaaaaa catcaagcaa atgtacttgt gcctgcccca gggtgagaaa 240 gtccaagcca tgtatatctg ggttgatggt actggagaag gactgcgctg caaaacccgc 300 accctggact gtgagcccaa gtgtgtagaa gagttacctg agtggaattt tgatggctct 360 agtacctttc agtctgaggg ctccaacagt gacatgtatc tcagccctgt tgccatgttt 420 cgggacccct tccgcagaga tcccaacaag ctggtgttct gtgaagtttt caagtacaac 480 cggaagcctg cagagacaaa tttaaggcac tcgtgtaaac ggataatgga catggtgagc 540 aaccagcacc cctggtttgg aatggaacag gagtatactc tgatgggaac agatgggcac 600 ccttttggtt ggccttccaa tggctttcct gggccccaag gtccgtatta ctgtggtgtg 660 ggcgcagaca aagcctatgg cagggatatc gtggaggctc actaccgcgc ctgcttgtat 720 gctggggtca agattacagg aacaaatgct gaggtcatgc ctgcccagtg ggagttccaa 780 ataggaccct gtgaaggaat ccgcatggga gatcatctct gggtggcccg tttcatcttg 840 catcgagtat gtgaggactt tggggtaata gcaacctttg accccaagcc cattcctggg 900 aactggaatg gtgcaggctg ccataccaac tttagcacca aggccatgcg ggaggagaat 960 ggtctgaagc acatcgagga ggccatcgag aaactaagca agcggcacag gtaccacatt 1020 cgagcctacg atcccaaggg gggcctggac aatgcccgtc gtctgactgg gttccacgaa 1080 acgtccaaca tcaacgactt ttctgctggt gtcgccaatc gcagtgccag catccgcatt 1140 ccccggactg tcggccagga gaagaaaggt tactttgaag atcgccgccc ctctgccaat 1200 tgtgacccct ttgcagtgac agaagccatc gtccgcacat gccttctcaa tgagactggc 1260 gacgagccct tccaatacaa aaactaatta gactttgagt gatcttgagc ctttcctagt 1320 tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt ggtgtgacat 1380 aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa tttttaagtg 1440 tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca acctatggaa 1500 ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt tgctcagaag 1560 aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact cctccaaaaa 1620 agaagagaaa ggtagaagat cccaaggact ttccttcaga attgctaagt tttttgagtc 1680 atgctgtgtt tagtaataga actcttgctt gctttgctat ttacaccaca aaggaaaaag 1740 ctgcactgct atacaagaaa attatggaaa aatattctgt aacctttata agtaggcata 1800 acagttataa tcataacata ctgttttttc ttactccaca caggcataga gtgtctgcta 1860 ttaataacta tgctcaaaaa ttgtgtacct ttagcttttt aatttgtaaa ggggttaata 1920 aggaatattt gatgtatagt gccttgacta gagatcataa tcagccatac cacatttgta 1980 gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg 2040 aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat 2100 agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc 2160 aaactcatca atgtatctta tcatgtctgg ggcgcgccga agacaa 2206 <210> 368 <211> 2366 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 368 tagtcttcgt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga 60 ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg 120 cctaggcttt tgcaaaggac acaagacagg cttgcgccac catggttgag aataccactt 180 tatcccgcgt cagggagagg cagtgcgtaa aaagacgcgg aaccatgtga aatactggtt 240 tttagtgcgc cagatctcta taatctcgcg caacctattt tcccctcgaa cactttttaa 300 gccgtagata aacaggctgg gacacttcac atggccacct cagcaagttc ccacttgaac 360 aaaaacatca agcaaatgta cctgtgcctg ccccagggtg agaaagtcca agccatgtat 420 atctgggttg atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag 480 cccaagtgtg tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct 540 gagggctcca acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc 600 cgggagccca acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag 660 acaaatttaa ggcactcctg taaacggata atggacatgg tgagcaacca gcacccctgg 720 tttggaatgg aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct 780 tccaatggct ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc 840 tatggcaggg atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt 900 acaggaacaa atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa 960 ggaatccaca tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgag 1020 gactttgggg taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca 1080 ggctgccata ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc 1140 gaggaggcca tcgagaaact aagcaagcgg caccagtacc acattcgagc ctacgatccc 1200 aaggggggcc tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac 1260 gacttttctg ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc 1320 caggagaaga aaggttactt tgaagatcgc cgcccctctg ccaattgtga cccctttgca 1380 gtgacagaag ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa 1440 tacaaaaact aataattaga ctttgagtga tcttgagcct ttcctagttc atcccacccc 1500 gccccagaga gatctttgtg aaggaacctt acttctgtgg tgtgacataa ttggacaaac 1560 tacctacaga gatttaaagc tctaaggtaa atataaaatt tttaagtgta taatgtgtta 1620 aactactgat tctaattgtt tgtgtatttt agattccaac ctatggaact gatgaatggg 1680 agcagtggtg gaatgccttt aatgaggaaa acctgttttg ctcagaagaa atgccatcta 1740 gtgatgatga ggctactgct gactctcaac attctactcc tccaaaaaag aagagaaagg 1800 tagaagatcc caaggacttt ccttcagaat tgctaagttt tttgagtcat gctgtgttta 1860 gtaatagaac tcttgcttgc tttgctattt acaccacaaa ggaaaaagct gcactgctat 1920 acaagaaaat tatggaaaaa tattctgtaa cctttataag taggcataac agttataatc 1980 ataacatact gttttttctt actccacaca ggcatagagt gtctgctatt aataactatg 2040 ctcaaaaatt gtgtaccttt agctttttaa tttgtaaagg ggttaataag gaatatttga 2100 tgtatagtgc cttgactaga gatcataatc agccatacca catttgtaga ggttttactt 2160 gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 2220 gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 2280 ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat 2340 gtatcttatc atgtctggga agacac 2366 <210> 369 <211> 2452 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 369 tagtcttcgt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga 60 ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg 120 cctaggcttt tgcaaaggac acaagacagg cttgcgccac catggttgag aataccactt 180 tatcccgcgt cagggagagg cagtgcgtaa aaagacgcgg aaccatgtga aatactggtt 240 tttagtgcgc cagatctcta taatctcgcg caacctattt tcccctcgaa cactttttaa 300 gccgtagata aacaggctgg gacacttcac atggccacct cagcaagttc ccacttgaac 360 aaaaacatca agcaaatgta cctgtgcctg ccccagggtg agaaagtcca agccatgtat 420 atctgggttg atggtactgg agaaggactg cgctgcaaaa cccgcaccct ggactgtgag 480 cccaagtgtg tagaagagtt acctgagtgg aattttgatg gctctagtac ctttcagtct 540 gagggctcca acagtgacat gtatctcagc cctgttgcca tgtttcggga ccccttccgc 600 cgggagccca acaagctggt gttctgtgaa gttttcaagt acaaccggaa gcctgcagag 660 acaaatttaa ggcactcctg taaacggata atggacatgg tgagcaacca gcacccctgg 720 tttggaatgg aacaggagta tactctgatg ggaacagatg ggcacccttt tggttggcct 780 tccaatggct ttcctgggcc ccaaggtccg tattactgtg gtgtgggcgc agacaaagcc 840 tatggcaggg atatcgtgga ggctcactac cgcgcctgct tgtatgctgg ggtcaagatt 900 acaggaacaa atgctgaggt catgcctgcc cagtgggagt tccaaatagg accctgtgaa 960 ggaatccaca tgggagatca tctctgggtg gcccgtttca tcttgcatcg agtatgtgag 1020 gactttgggg taatagcaac ctttgacccc aagcccattc ctgggaactg gaatggtgca 1080 ggctgccata ccaactttag caccaaggcc atgcgggagg agaatggtct gaagcacatc 1140 gaggaggcca tcgagaaact aagcaagcgg caccagtacc acattcgagc ctacgatccc 1200 aaggggggcc tggacaatgc ccgtcgtctg actgggttcc acgaaacgtc caacatcaac 1260 gacttttctg ctggtgtcgc caatcgcagt gccagcatcc gcattccccg gactgtcggc 1320 caggagaaga aaggttactt tgaagatcgc cgcccctctg ccaattgtga cccctttgca 1380 gtgacagaag ccatcgtccg cacatgcctt ctcaatgaga ctggcgacga gcccttccaa 1440 tacaaaaact ggatccgctc agacatgata agatacattg atgagtttgg acaaaccaca 1500 actagaatgc agtgataatt agactttgag tgatcttgag cctttcctag ttcatcccac 1560 cccgccccag agagatcttt gtgaaggaac cttacttctg tggtgtgaca taattggaca 1620 aactacctac agagatttaa agctctaagg taaatataaa atttttaagt gtataatgtg 1680 ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga actgatgaat 1740 gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa gaaatgccat 1800 ctagtgatga tgaggctact gctgactctc aacattctac tcctccaaaa aagaagagaa 1860 aggtagaaga tcccaaggac tttccttcag aattgctaag ttttttgagt catgctgtgt 1920 ttagtaatag aactcttgct tgctttgcta tttacaccac aaaggaaaaa gctgcactgc 1980 tatacaagaa aattatggaa aaatattctg taacctttat aagtaggcat aacagttata 2040 atcataacat actgtttttt cttactccac acaggcatag agtgtctgct attaataact 2100 atgctcaaaa attgtgtacc tttagctttt taatttgtaa aggggttaat aaggaatatt 2160 tgatgtatag tgccttgact agagatcata atcagccata ccacatttgt agaggtttta 2220 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 2280 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 2340 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 2400 aatgtatctt atcatgtctg ggaagacacc gtcaaaaggg cgacacaaaa tt 2452 <210> 370 <211> 1945 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 370 cagctgcttc atccccgtgg cccgttgctc gcgtttgctg gcggtgtccc cggaagaaat 60 atatttgcat gtctttagtt ctatgatgac acaaaccccg cccagcgtct tgtcattggc 120 gaaaacacgc agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg 180 acgcgtgtgg cctcgaacac agagcgactc tgcagggtgg catggccacc tcagcaagtt 240 cccacttgaa caaaaacatc aagcaaatgt acctgtgcct gccccagggt gagaaagtcc 300 aagccatgta tatctgggtt gatggtactg gagaaggact gcgctgcaaa acccgcaccc 360 tggactgtga gcccaagtgt gtagaagagt tacctgagtg gaattttgat ggctctagta 420 cctttcagtc tgagggctcc aacagtgaca tgtatctcag ccctgttgcc atgtttcggg 480 accccttccg ccgggagccc aacaagctgg tgttctgtga agttttcaag tacaaccgga 540 agcctgcaga gacaaattta aggcactcct gtaaacggat aatggacatg gtgagcaacc 600 agcacccctg gtttggaatg gaacaggagt atactctgat gggaacagat gggcaccctt 660 ttggttggcc ttccaatggc tttcctgggc cccaaggtcc gtattactgt ggtgtgggcg 720 cagacaaagc ctatggcagg gatatcgtgg aggctcacta ccgcgcctgc ttgtatgctg 780 gggtcaagat tacaggaaca aatgctgagg tcatgcctgc ccagtgggag ttccaaatag 840 gaccctgtga aggaatccac atgggagatc atctctgggt ggcccgtttc atcttgcatc 900 gagtatgtga ggactttggg gtaatagcaa cctttgaccc caagcccatt cctgggaact 960 ggaatggtgc aggctgccat accaacttta gcaccaaggc catgcgggag gagaatggtc 1020 tgaagcacat cgaggaggcc atcgagaaac taagcaagcg gcaccagtac cacattcgag 1080 cctacgatcc caaggggggc ctggacaatg cccgtcgtct gactgggttc cacgaaacgt 1140 ccaacatcaa cgacttttct gctggtgtcg ccaatcgcag tgccagcatc cgcattcccc 1200 ggactgtcgg ccaggagaag aaaggttact ttgaagatcg ccgcccctct gccaattgtg 1260 acccctttgc agtgacagaa gccatcgtcc gcacatgcct tctcaatgag actggcgacg 1320 agcccttcca atacaaaaac tggatccgct cagacatgat aagatacatt gatgagtttg 1380 gacaaaccac aactagaatg cagtgataat tagactttga gtgatcttga gcctttccta 1440 gttcatccca ccccgcccca gagagatctt tgtgaaggaa ccttacttct gtggtgtgac 1500 ataattggac aaactaccta cagagattta aagctctaag gtaaatataa aatttttaag 1560 tgtataatgt gttaaactac tgattctaat tgtttgtgta ttttagattc caacctatgg 1620 aactgatgaa tgggagcagt ggtggaatgc ctttaatgag gaaaacctgt tttgctcaga 1680 agaaatgcca tctagtgatg atgaggctac tgctgactct caacattcta ctcctctcgc 1740 tttcttgctg tccaatttct attaaaggtt cctttgttcc ctaagtccaa ctactaaact 1800 gggggatatt atgaagggcc ttgagcatct ggattctgcc taataaaaaa catttatttt 1860 cattgcaatg atgtatttaa attatttctg aatattttac taaaaaggga atgtgggagg 1920 tcagtgcatt taaaacataa agaaa 1945 <210> 371 <211> 1136 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 371 gttttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 60 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 120 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 180 ctttaataga aattggacag caagaaagcg agttattagc cctcccacac ataaccagag 240 ggcagcaatt cacgaatccc aactgccgtc ggctgtccat cactgtcctt cactatggct 300 ttgatcccag gatgcagatc gagaagcacc tgtcggcacc gtccgcaggg gctcaagatg 360 cccctgttct catttccgat cgcgacgata caagtcaggt tgccagctgc cgcagcagca 420 gcagtgccca gcaccacgag ttctgcacaa ggtcccccag taaaatgata tacattgaca 480 ccagtgaaga tgcggccgtc gctagagaga gctgcgctgg cgacgctgta atcttcagag 540 atggggatgc tgttgattgt agccgttgct ctttcaatga gggtggattc ttcttgagac 600 aaaggcttgg ccatggtggc gacgtgcgct ccggaggctt gcagaatgcg gaacaccgcg 660 cgggcaggaa cagggcccac actaccgccc cacaccccgc ctcccgcacc gccccttccc 720 ggccgctgct ctcagaaagc gaaggagcaa agctgctatt ggccgctgcc ccaaaggcct 780 acccgcttcc attgctcagc ggtgctgtcc atctgcacga gactagtgag tcgtgctact 840 tccatttgtc acgtcctgca cgacgcgagc tgcggggcgg gggggaactt cctgactagg 900 ggaggagtag aaggtggcgc gaaggggcca ccaaagaacg gagccggttg gcgcctaccg 960 gtggatgtgg aatgtgtgcg aggccagagg ccacttgtgt agcgccaagt gcccagcggg 1020 gctgctaaag cgcatgctcc agactgcctt gggaaaagcg cctcccctac ccggtagaga 1080 aacttgatct gtcgccgcaa ttcaaacttc gtgaggctcc ggtgcccgtc agtgta 1136 <210> 372 <211> 1055 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 372 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 ttagccctcc cacacataac cagagggcag caattcacga atcccaactg ccgtcggctg 300 tccatcactg tccttcacta tggctttgat cccaggatgc agatcgagaa gcacctgtcg 360 gcaccgtccg caggggctca agatgcccct gttctcattt ccgatcgcga cgatacaagt 420 caggttgcca gctgccgcag cagcagcagt gcccagcacc acgagttctg cacaaggtcc 480 cccagtaaaa tgatatacat tgacaccagt gaagatgcgg ccgtcgctag agagagctgc 540 gctggcgacg ctgtaatctt cagagatggg gatgctgttg attgtagccg ttgctctttc 600 aatgagggtg gattcttctt gagacaaagg cttggccatg tgaagtgtcc cagcctgttt 660 atctacggct taaaaagtgt tcgaggggaa aataggttgc gcgagattat agagatctgg 720 cgcactaaaa accagtattt cacatgagtc cgcgtctttt tacgcactgc ctctccctga 780 cgcgggataa agtggtattc tcaaacatat ctcgcaagcc tgtcttgtgt ccctgcagag 840 tcgctctgtg ttcgaggcca cacgcgtcac cttaatatgc gaagtggacc tgggaccgcg 900 ccgccccgac tgcatctgcg tgttttcgcc aatgacaaga cgctgggcgg ggtttgtgtc 960 atcatagaac taaagacatg caaatatatt tcttccgggg acaccgccag caaacgcgag 1020 caacgggcca cggggatgaa gcagctggaa gacta 1055 <210> 373 <211> 868 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 373 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 ttagccctcc cacacataac cagagggcag caattcacga atcccaactg ccgtcggctg 300 tccatcactg tccttcacta tggctttgat cccaggatgc agatcgagaa gcacctgtcg 360 gcaccgtccg caggggctca agatgcccct gttctcattt ccgatcgcga cgatacaagt 420 caggttgcca gctgccgcag cagcagcagt gcccagcacc acgagttctg cacaaggtcc 480 cccagtaaaa tgatatacat tgacaccagt gaagatgcgg ccgtcgctag agagagctgc 540 gctggcgacg ctgtaatctt cagagatggg gatgctgttg attgtagccg ttgctctttc 600 aatgagggtg gattcttctt gagacaaagg cttggccatg ccaccctgca gagtcgctct 660 gtgttcgagg ccacacgcgt caccttaata tgcgaagtgg acctgggacc gcgccgcccc 720 gactgcatct gcgtgttttc gccaatgaca agacgctggg cggggtttgt gtcatcatag 780 aactaaagac atgcaaatat atttcttccg gggacaccgc cagcaaacgc gagcaacggg 840 ccacggggat gaagcagctg gaagacta 868 <210> 374 <211> 1307 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 374 aagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggccaagcct ttgtctcaag aagaatccac cctcattgaa agagcaacgg 720 ctacaatcaa cagcatcccc atctctgaag attacagcgt cgccagcgca gctctctcta 780 gcgacggccg catcttcact ggtgtcaatg tatatcattt tactggggga ccttgtgcag 840 aactcgtggt gctgggcact gctgctgctg cggcagctgg caacctgact tgtatcgtcg 900 cgatcggaaa tgagaacagg ggcatcttga gcccctgcgg acggtgccga caggtgcttc 960 tcgatctgca tcctgggatc aaagccatag tgaaggacag tgatggacag ccgacggcag 1020 ttgggattcg tgaattgctg ccctctggtt atgtgtggga gggctaatgg atccgctcag 1080 acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat 1140 gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata 1200 aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg 1260 aggtttttta aagcaagtaa aacctctaca aatgtggtag aagacaa 1307 <210> 375 <211> 1200 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 375 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag ttagccctcc cacacataac 240 cagagggcag caattcacga atcccaactg ccgtcggctg tccatcactg tccttcacta 300 tggctttgat cccaggatgc agatcgagaa gcacctgtcg gcaccgtccg caggggctca 360 agatgcccct gttctcattt ccgatcgcga cgatacaagt caggttgcca gctgccgcag 420 cagcagcagt gcccagcacc acgagttctg cacaaggtcc cccagtaaaa tgatatacat 480 tgacaccagt gaagatgcgg ccgtcgctag agagagctgc gctggcgacg ctgtaatctt 540 cagagatggg gatgctgttg attgtagccg ttgctctttc aatgagggtg gattcttctt 600 gagacaaagg cttggccatg gtggcggacg aaaggcccgg agatgaggaa gaggagaaca 660 gcgcggcaga cgtgcgcttt tgaagcgtgc agaatgccgg gcctccggag gaccttcggg 720 cgcccgcccc gcccctgagc ccgcccctga gcccgccccc ggacccaccc cttcccagcc 780 tctgagccca gaaagcgaag gagcaaagct gctattggcc gctgccccaa aggcctaccc 840 gcttccattg ctcagcggtg ctgtccatct gcacgagact agtgagtcgt gctacttcca 900 tttgtcacgt cctgcacgac gcgagctgcg gggcgggggg gaacttcctg actaggggag 960 gagtagaagg tggcgcgaag gggccaccaa agaacggagc cggttggcgc ctaccggtgg 1020 atgtggaatg tgtgcgaggc cagaggccac ttgtgtagcg ccaagtgccc agcggggctg 1080 ctaaagcgca tgctccagac tgccttggga aaagcgcctc ccctacccgg tagagaaact 1140 tgatctgtcg ccgcaattca agcttcgtga ggctccggtg cccgtcagtg acctgctata 1200 <210> 376 <211> 1145 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 376 gtgtcttctt tctttatgtt ttaaatgcac tgatctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtt agccctccca cacataacca 240 gagggcagca attcacgaat cccaactgcc gtcggctgtc catcactgtc cttcactatg 300 gctttgatcc caggatgcag atcgagaagc acctgtcggc accgtccgca ggggctcaag 360 atgcccctgt tctcatttcc gatcgcgacg atacaagtca ggttgccagc tgccgcagca 420 gcagcagtgc ccagcaccac gagttctgca caaggtcccc cagtaaaatg atatacattg 480 acaccagtga agatgcggcc gtcgctagag agagctgcgc tggcgacgct gtaatcttca 540 gagatgggga tgctgttgat tgtagccgtt gctctttcaa tgagggtgga ttcttcttga 600 gacaaaggct tggccatggt ggcgacgtgc gctccggagg cttgcagaat gcggaacacc 660 gcgcgggcag gaacagggcc cacactaccg ccccacaccc cgcctcccgc accgcccctt 720 cccggccgct gctctcagaa agcgaaggag caaagctgct attggccgct gccccaaagg 780 cctacccgct tccattgctc agcggtgctg tccatctgca cgagactagt gagtcgtgct 840 acttccattt gtcacgtcct gcacgacgcg agctgcgggg cgggggggaa cttcctgact 900 aggggaggag tagaaggtgg cgcgaagggg ccaccaaaga acggagccgg ttggcgccta 960 ccggtggatg tggaatgtgt gcgaggccag aggccacttg tgtagcgcca agtgcccagc 1020 ggggctgcta aagcgcatgc tccagactgc cttgggaaaa gcgcctcccc tacccggtag 1080 agaaacttga tctgtcgccg caattcaaac ttcgtgaggc tccggtgccc gtcagtggaa 1140 gacta 1145 <210> 377 <211> 812 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 377 aagtcttctt aattaatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatggc caagcctttg 180 tctcaagaag aatccaccct cattgaaaga gcaacggcta caatcaacag catccccatc 240 tctgaagatt acagcgtcgc cagcgcagct ctctctagcg acggccgcat cttcactggt 300 gtcaatgtat atcattttac tgggggacct tgtgcagaac tcgtggtgct gggcactgct 360 gctgctgcgg cagctggcaa cctgacttgt atcgtcgcga tcggaaatga gaacaggggc 420 atcttgagcc cctgcggacg gtgccgacag gtgcttctcg atctgcatcc tgggatcaaa 480 gccatagtga aggacagtga tggacagccg acggcagttg ggattcgtga attgctgccc 540 tctggttatg tgtgggaggg ctaatggatc cgctcagaca tgataagata cattgatgag 600 tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat 660 gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc 720 attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac 780 ctctacaaat gtggtaggcg cgccgaagac aa 812 <210> 378 <211> 1533 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 378 tatagcaggt cactgacggg caccggagcc tcacgaagct tgaattgcgg cgacagatca 60 agtttccagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg tgtccccgga 120 agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca gcgtcttgtc 180 attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt 240 aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg aaaaagcctg 300 aactcaccgc gacgtctgtc gagaagtttc tgatcgaaaa gttcgacagc gtgtccgacc 360 tgatgcagct ctcggagggc gaagaatctc gtgctttcag cttcgatgta ggagggcgtg 420 gatatgtcct gcgggtaaat agctgcgccg atggtttcta caaagatcgt tatgtttatc 480 ggcactttgc atcggccgcg ctcccgattc cggaagtgct tgacattggg gaattcagcg 540 agagcctgac ctattgcatc tcccgccgtg cacagggtgt cacgttgcaa gatctgcctg 600 aaaccgaact gcccgctgtt ctgcagccgg tcgcggaggc catggatgcg atcgctgcgg 660 ccgatcttag ccagacgagc gggttcggcc cattcggacc gcaaggaatc ggtcaataca 720 ctacatggcg tgatttcata tgcgcgattg ctgatcccca tgtgtatcac tggcaaactg 780 tgatggacga caccgtcagt gcgtccgtcg cgcaggctct cgatgagctg atgctttggg 840 ccgaggactg ccccgaagtc cggcacctcg tgcacgcgga tttcggctcc aacaatgtcc 900 tgacggacaa tggccgcata acagcggtca ttgactggag cgaggcgatg ttcggggatt 960 cccaatacga ggtcgccaac atcttcttct ggaggccgtg gttggcttgt atggagcagc 1020 agacgcgcta cttcgagcgg aggcatccgg agcttgcagg atcgccgcgg ctccgggcgt 1080 atatgctccg cattggtctt gaccaactct atcagagctt ggttgacggc aatttcgatg 1140 atgcagcttg ggcgcagggt cgatgcgacg caatcgtccg atccggagcc gggactgtcg 1200 ggcgtacaca aatcgcccgc agaagcgcgg ccgtctggac cgatggctgt gtagaagtac 1260 tcgccgatag tggaaaccga cgccccagca ctcgtccgag ggcaaaggaa tagctcgctt 1320 tcttgctgtc caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg 1380 gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca 1440 ttgcaatgat gtatttaaat tatttctgaa tattttacta aaaagggaat gtgggaggtc 1500 agtgcattta aaacataaag aaaacctgct tac 1533 <210> 379 <211> 1827 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 379 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag ctattccttt gccctcggac 240 gagtgctggg gcgtcggttt ccactatcgg cgagtacttc tacacagcca tcggtccaga 300 cggccgcgct tctgcgggcg atttgtgtac gcccgacagt cccggctccg gatcggacga 360 ttgcgtcgca tcgaccctgc gcccaagctg catcatcgaa attgccgtca accaagctct 420 gatagagttg gtcaagacca atgcggagca tatacgcccg gagccgcggc gatcctgcaa 480 gctccggatg cctccgctcg aagtagcgcg tctgctgctc catacaagcc aaccacggcc 540 tccagaagaa gatgttggcg acctcgtatt gggaatcccc gaacatcgcc tcgctccagt 600 caatgaccgc tgttatgcgg ccattgtccg tcaggacatt gttggagccg aaatccgcgt 660 gcacgaggtg ccggacttcg gggcagtcct cggcccaaag catcagctca tcgagagcct 720 gcgcgacgga cgcactgacg gtgtcgtcca tcacagtttg ccagtgatac acatggggat 780 cagcaatcgc gcatatgaaa tcacgccatg tagtgtattg accgattcct tgcggtccga 840 atgggccgaa cccgctcgtc tggctaagat cggccgcagc gatcgcatcc atggcctccg 900 cgaccggctg cagaacagcg ggcagttcgg tttcaggcag atcttgcaac gtgacaccct 960 gtgcacggcg ggagatgcaa taggtcaggc tctcgctgaa ttccccaatg tcaagcactt 1020 ccggaatcgg gagcgcggcc gatgcaaagt gccgataaac ataacgatct ttgtagaaac 1080 catcggcgca gctatttacc cgcaggacat atccacgccc tcctacatcg aagctgaaag 1140 cacgagattc ttcgccctcc gagagctgca tcaggtcgga cacgctgtcg aacttttcga 1200 tcagaaactt ctcgacagac gtcgcggtga gttcaggctt tttcatggtg gcggacgaaa 1260 ggcccggaga tgaggaagag gagaacagcg cggcagacgt gcgcttttga agcgtgcaga 1320 atgccgggcc tccggaggac cttcgggcgc ccgccccgcc cctgagcccg cccctgagcc 1380 cgcccccgga cccacccctt cccagcctct gagcccagaa agcgaaggag caaagctgct 1440 attggccgct gccccaaagg cctacccgct tccattgctc agcggtgctg tccatctgca 1500 cgagactagt gagtcgtgct acttccattt gtcacgtcct gcacgacgcg agctgcgggg 1560 cgggggggaa cttcctgact aggggaggag tagaaggtgg cgcgaagggg ccaccaaaga 1620 acggagccgg ttggcgccta ccggtggatg tggaatgtgt gcgaggccag aggccacttg 1680 tgtagcgcca agtgcccagc ggggctgcta aagcgcatgc tccagactgc cttgggaaaa 1740 gcgcctcccc tacccggtag agaaacttga tctgtcgccg caattcaagc ttcgtgaggc 1800 tccggtgccc gtcagtgacc tgctata 1827 <210> 380 <211> 1680 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 380 gagtcttcgg agacgcgaag aacaacgaga agatcctcaa cttctcctaa gccttttcac 60 taatagggag aagttcgatg gggcagcctt gggcagaccc acacttctgc tccatttccc 120 tggttcctgc agctctcaga ttctcccatt ttattcggga agcagctttc tggtttctgg 180 gtcctggatg tccttggtgc acactccaag gactcctcgt ccttaatcca tagtctgtat 240 tccctgagtc ctatcctggg aaccctcatc cggtcacttc ctcggcggga caatctcagc 300 tcccctcccc ctctcaggtc ggagcccaca cgcttggtgc gtgcacattt caaaaacgag 360 gcgggtccaa aaagagggag ggggggaatg agagaggccc agctactcgc ggctttacgg 420 gtgcacgtag ctcaggcctc tgcgcccttg agctgggact ggatgagccg agcgggaggc 480 ggggcgcgcg tcatcagctc cccccaccat ccagttccta taaatacgga ctgcagccct 540 ccctggtgct ctctgctcct ccctgttcta gagacagccg catcttcttg tgcagtgcca 600 ggctctctgc tcctcctgtt cgacagtcag ccgcatcttc ttttgcgtcg ccagatgatt 660 gaacaagatg gattgcacgc tggttctccg gccgcttggg tggagaggct attcggctat 720 gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag 780 gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actgcaggac 840 gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac 900 gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc 960 ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg 1020 ctgcatacgc ttgatccggc tacatgccca ttcgaccacc aagcgaaaca tcgcatcgag 1080 cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaggaacat 1140 caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgcatgcc cgacggcgag 1200 gatctcgtcg tgacccatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc 1260 ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg 1320 ttggctaccc gtgatattgc tgaggaactt ggcggcgaat gggctgaccg cttcctcgtg 1380 ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag 1440 ttcttctgat gactcgcttt cttgctgtcc aatttctatt aaaggttcct ttgttcccta 1500 agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga ttctgcctaa 1560 taaaaaacat ttattttcat tgcaatgatg tatttaaatt atttctgaat attttactaa 1620 aaagggaatg tgggaggtca gtgcatttaa aacataaaga aaacctgctt acgaagactc 1680 <210> 381 <211> 1305 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 381 tatagcaggt cactgacggg caccggagcc tcacgaagtt tgaattgcgg cgacagatca 60 agtttccagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg tgtccccgga 120 agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca gcgtcttgtc 180 attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt 240 aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg attgaacaag 300 atggattgca cgctggttct ccggccgctt gggtggagag gctattcggc tatgactggg 360 cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc 420 cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag gacgaggcag 480 cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc gacgttgtca 540 ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat 600 ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg cggctgcata 660 cgcttgatcc ggctacatgc ccattcgacc accaagcgaa acatcgcatc gagcgagcac 720 gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaggaa catcaggggc 780 tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc gaggatctcg 840 tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc cgcttttctg 900 gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata gcgttggcta 960 cccgtgatat tgctgaggaa cttggcggcg aatgggctga ccgcttcctc gtgctttacg 1020 gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac gagttcttct 1080 gatgactcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc ctaagtccaa 1140 ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc taataaaaaa 1200 catttatttt cattgcaatg atgtatttaa attatttctg aatattttac taaaaaggga 1260 atgtgggagg tcagtgcatt taaaacataa agaaaacctg cttac 1305 <210> 382 <211> 1599 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 382 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcatcagaag aactcgtcaa 240 gaaggcgata gaaggcgatg cgctgcgaat cgggagcggc gataccgtaa agcacgagga 300 agcggtcagc ccattcgccg ccaagttcct cagcaatatc acgggtagcc aacgctatgt 360 cctgatagcg gtccgccaca cccagccggc cacagtcgat gaatccagaa aagcggccat 420 tttccaccat gatattcggc aagcaggcat cgccatgggt cacgacgaga tcctcgccgt 480 cgggcatgcg cgccttgagc ctggcgaaca gttcggctgg cgcgagcccc tgatgttcct 540 cgtccagatc atcctgatcg acaagaccgg cttccatccg agtacgtgct cgctcgatgc 600 gatgtttcgc ttggtggtcg aatgggcatg tagccggatc aagcgtatgc agccgccgca 660 ttgcatcagc catgatggat actttctcgg caggagcaag gtgagatgac aggagatcct 720 gccccggcac ttcgcccaat agcagccagt cccttcccgc ttcagtgaca acgtcgagca 780 cagctgcgca aggaacgccc gtcgtggcca gccacgatag ccgcgctgcc tcgtcctgca 840 gttcattcag ggcaccggac aggtcggtct tgacaaaaag aaccgggcgc ccctgcgctg 900 acagccggaa cacggcggca tcagagcagc cgattgtctg ttgtgcccag tcatagccga 960 atagcctctc cacccaagcg gccggagaac cagcgtgcaa tccatcttgt tcaatcatgg 1020 tggcggacga aaggcccgga gatgaggaag aggagaacag cgcggcagac gtgcgctttt 1080 gaagcgtgca gaatgccggg cctccggagg accttcgggc gcccgccccg cccctgagcc 1140 cgcccctgag cccgcccccg gacccacccc ttcccagcct ctgagcccag aaagcgaagg 1200 agcaaagctg ctattggccg ctgccccaaa ggcctacccg cttccattgc tcagcggtgc 1260 tgtccatctg cacgagacta gtgagtcgtg ctacttccat ttgtcacgtc ctgcacgacg 1320 cgagctgcgg ggcggggggg aacttcctga ctaggggagg agtagaaggt ggcgcgaagg 1380 ggccaccaaa gaacggagcc ggttggcgcc taccggtgga tgtggaatgt gtgcgaggcc 1440 agaggccact tgtgtagcgc caagtgccca gcggggctgc taaagcgcat gctccagact 1500 gccttgggaa aagcgcctcc cctacccggt agagaaactt gatctgtcgc cgcaattcaa 1560 acttcgtgag gctccggtgc ccgtcagtga cctgctata 1599 <210> 383 <211> 1130 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 383 ttgtcttcgg cgcgcctccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatgac cgagtacaag 180 cccacggtgc gcctcgccac ccgcgacgac gtccccaggg ccgtacgcac cctcgccgcc 240 gcgttcgccg actaccccgc cacgcgccac accgtcgatc cggaccgcca catcgagcgg 300 gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc tcgacatcgg caaggtgtgg 360 gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc cggagagcgt cgaagcgggg 420 gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga gcggttcccg gctggccgcg 480 cagcaacaga tggaaggcct cctggcgccg caccggccca aggagcccgc gtggttcctg 540 gccaccgtcg gcgtgtcgcc cgaccaccag ggcaagggtc tgggcagcgc cgtcgtgctc 600 cccggagtgg aggcggccga gcgcgccggg gtgcccgcct tcctggagac atccgcgccc 660 cgcaacctcc ccttctacga gcggctcggc ttcaccgtca ccgccgacgt cgaggtgccc 720 gaaggaccgc gcacctggtg catgacccgc aagcccggtg cctgatggat ccgctcagac 780 atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc 840 tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa 900 caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag 960 gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tcgataatat atggtagggt 1020 tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg agtcgggcgc 1080 gcaaaaatga agtgaagttc ctatactttc tagattaatt aagaagactt 1130 <210> 384 <211> 1013 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 384 ttgtcttcgg cgcgcctacc acatttgtag aggttttact tgctttaaaa aacctcccac 60 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 120 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 180 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgag 240 cggatccatc aggcaccggg cttgcgggtc atgcaccagg tgcgcggtcc ttcgggcacc 300 tcgacgtcgg cggtgacggt gaagccgagc cgctcgtaga aggggaggtt gcggggcgcg 360 gatgtctcca ggaaggcggg caccccggcg cgctcggccg cctccactcc ggggagcacg 420 acggcgctgc ccagaccctt gccctggtgg tcgggcgaca cgccgacggt ggccaggaac 480 cacgcgggct ccttgggccg gtgcggcgcc aggaggcctt ccatctgttg ctgcgcggcc 540 agccgggaac cgctcaactc ggccatgcgc gggccgatct cggcgaacac cgcccccgct 600 tcgacgctct ccggcgtggt ccagaccgcc accgcggcgc cgtcgtccgc gacccacacc 660 ttgccgatgt cgagcccgac gcgcgtgagg aagagttctt gcagctcggt gacccgctcg 720 atgtggcggt ccggatcgac ggtgtggcgc gtggcggggt agtcggcgaa cgcggcggcg 780 agggtgcgta cggccctggg gacgtcgtcg cgggtggcga ggcgcaccgt gggcttgtac 840 tcggtcattt tgcaaaagcc tatacctcca aaaaagcctc ctcactactt ctggaatagc 900 tcagaggccg aggcggcctc ggcctctgca taaataaaaa aaattagtca gccatggggc 960 ggagaatggg cggaactggg cggagttagg ggcgggatta attaagaaga ctt 1013 <210> 385 <211> 1502 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 385 gagtcttcgg agacgcgaag aacaacgaga agatcctcaa cttctcctaa gccttttcac 60 taatagggag aagttcgatg gggcagcctt gggcagaccc acacttctgc tccatttccc 120 tggttcctgc agctctcaga ttctcccatt ttattcggga agcagctttc tggtttctgg 180 gtcctggatg tccttggtgc acactccaag gactcctcgt ccttaatcca tagtctgtat 240 tccctgagtc ctatcctggg aaccctcatc cggtcacttc ctcggcggga caatctcagc 300 tcccctcccc ctctcaggtc ggagcccaca cgcttggtgc gtgcacattt caaaaacgag 360 gcgggtccaa aaagagggag ggggggaatg agagaggccc agctactcgc ggctttacgg 420 gtgcacgtag ctcaggcctc tgcgcccttg agctgggact ggatgagccg agcgggaggc 480 ggggcgcgcg tcatcagctc cccccaccat ccagttccta taaatacgga ctgcagccct 540 ccctggtgct ctctgctcct ccctgttcta gagacagccg catcttcttg tgcagtgcca 600 ggctctctgc tcctcctgtt cgacagtcag ccgcatcttc ttttgcgtcg ccagatgacc 660 gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc cgtacgcacc 720 ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc ggaccgccac 780 atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct cgacatcggc 840 aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc ggagagcgtc 900 gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag cggttcccgg 960 ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa ggagcccgcg 1020 tggttcctgg ccaccgtcgg cgtgtcgccc gaccaccagg gcaagggtct gggcagcgcc 1080 gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg tgcccgcctt cctggagaca 1140 tccgcgcccc gcaacctccc cttctacgag cggctcggct tcaccgtcac cgccgacgtc 1200 gaggtgcccg aaggaccgcg cacctggtgc atgacccgca agcccggtgc ctgatggatc 1260 cgctcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga 1320 aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc 1380 tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag 1440 gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaggcg cgccgaagac 1500 ac 1502 <210> 386 <211> 1256 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 386 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 tcaggcaccg ggcttgcggg tcatgcacca ggtgcgcggt ccttcgggca cctcgacgtc 300 ggcggtgacg gtgaagccga gccgctcgta gaaggggagg ttgcggggcg cggatgtctc 360 caggaaggcg ggcaccccgg cgcgctcggc cgcctccact ccggggagca cgacggcgct 420 gcccagaccc ttgccctggt ggtcgggcga cacgccgacg gtggccagga accacgcggg 480 ctccttgggc cggtgcggcg ccaggaggcc ttccatctgt tgctgcgcgg ccagccggga 540 accgctcaac tcggccatgc gcgggccgat ctcggcgaac accgcccccg cttcgacgct 600 ctccggcgtg gtccagaccg ccaccgcggc gccgtcgtcc gcgacccaca ccttgccgat 660 gtcgagcccg acgcgcgtga ggaagagttc ttgcagctcg gtgacccgct cgatgtggcg 720 gtccggatcg acggtgtggc gcgtggcggg gtagtcggcg aacgcggcgg cgagggtgcg 780 tacggccctg gggacgtcgt cgcgggtggc gaggcgcacc gtgggcttgt actcggtcat 840 gtgaagtgtc ccagcctgtt tatctacggc ttaaaaagtg ttcgagggga aaataggttg 900 cgcgagatta tagagatctg gcgcactaaa aaccagtatt tcacatgagt ccgcgtcttt 960 ttacgcactg cctctccctg acgcgggata aagtggtatt ctcaaacata tctcgcaagc 1020 ctgtcttgtg tccctgcaga gtcgctctgt gttcgaggcc acacgcgtca ccttaatatg 1080 cgaagtggac ctgggaccgc gccgccccga ctgcatctgc gtgttttcgc caatgacaag 1140 acgctgggcg gggtttgtgt catcatagaa ctaaagacat gcaaatatat ttcttccggg 1200 gacaccgcca gcaaacgcga gcaacgggcc acggggatga agcagctgga agacta 1256 <210> 387 <211> 1202 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 387 ttgtcttcgg cgcgcccagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatgg 840 atccgctcag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag 900 tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata 960 agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg 1020 gaggtgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtaa aatcgataat 1080 atatggtagg gttcatagcc agagtaacct ttttttttaa tttttatttt attttatttt 1140 tgagtcgggc gcgcaaaaat gaagtgaagt tcctatactt tctagattaa ttaagaagac 1200 tt 1202 <210> 388 <211> 1085 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 388 ttgtcttcgg cgcgcctacc acatttgtag aggttttact tgctttaaaa aacctcccac 60 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 120 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 180 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgag 240 cggatccatc aggcaccggg cttgcgggtc atgcaccagg tgcgcggtcc ttcgggcacc 300 tcgacgtcgg cggtgacggt gaagccgagc cgctcgtaga aggggaggtt gcggggcgcg 360 gatgtctcca ggaaggcggg caccccggcg cgctcggccg cctccactcc ggggagcacg 420 acggcgctgc ccagaccctt gccctggtgg tcgggcgaca cgccgacggt ggccaggaac 480 cacgcgggct ccttgggccg gtgcggcgcc aggaggcctt ccatctgttg ctgcgcggcc 540 agccgggaac cgctcaactc ggccatgcgc gggccgatct cggcgaacac cgcccccgct 600 tcgacgctct ccggcgtggt ccagaccgcc accgcggcgc cgtcgtccgc gacccacacc 660 ttgccgatgt cgagcccgac gcgcgtgagg aagagttctt gcagctcggt gacccgctcg 720 atgtggcggt ccggatcgac ggtgtggcgc gtggcggggt agtcggcgaa cgcggcggcg 780 agggtgcgta cggccctggg gacgtcgtcg cgggtggcga ggcgcaccgt gggcttgtac 840 tcggtcatgc caccctgcag agtcgctctg tgttcgaggc cacacgcgtc accttaatat 900 gcgaagtgga cctgggaccg cgccgccccg actgcatctg cgtgttttcg ccaatgacaa 960 gacgctgggc ggggtttgtg tcatcataga actaaagaca tgcaaatata tttcttccgg 1020 ggacaccgcc agcaaacgcg agcaacgggc cacggggatg aagcagctgt taattaagaa 1080 gactt 1085 <210> 389 <211> 1743 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 389 ttgtcttcgg cgcgcctacc acatttgtag aggttttact tgctttaaaa aacctcccac 60 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 120 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 180 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgag 240 cggatccatc aggcaccggg cttgcgggtc atgcaccagg tgcgcggtcc ttcgggcacc 300 tcgacgtcgg cggtgacggt gaagccgagc cgctcgtaga aggggaggtt gcggggcgcg 360 gatgtctcca ggaaggcggg caccccggcg cgctcggccg cctccactcc ggggagcacg 420 acggcgctgc ccagaccctt gccctggtgg tcgggcgaca cgccgacggt ggccaggaac 480 cacgcgggct ccttgggccg gtgcggcgcc aggaggcctt ccatctgttg ctgcgcggcc 540 agccgggaac cgctcaactc ggccatgcgc gggccgatct cggcgaacac cgcccccgct 600 tcgacgctct ccggcgtggt ccagaccgcc accgcggcgc cgtcgtccgc gacccacacc 660 ttgccgatgt cgagcccgac gcgcgtgagg aagagttctt gcagctcggt gacccgctcg 720 atgtggcggt ccggatcgac ggtgtggcgc gtggcggggt agtcggcgaa cgcggcggcg 780 agggtgcgta cggccctggg gacgtcgtcg cgggtggcga ggcgcaccgt gggcttgtac 840 tcggtcatgc caccctgcag agtcgctctg tgttcgaggc cacacgcgtc accttaatat 900 gcgaagtgga cctgggaccg cgccgccccg actgcatctg cgtgttttcg ccaatgacaa 960 gacgctgggc ggggtttgtg tcatcataga actaaagaca tgcaaatata tttcttccgg 1020 ggacaccgcc agcaaacgcg agcaacgggc cacggggatg aagcagctgt agactctggg 1080 tagaatgttc tgtttcctgt aatataaaat cataaagtga tgatattatc aagtgaaaag 1140 gaaatgtggt accttaatct ttccacatca agccaatatc atgctgaagg ccagagaatc 1200 ttttttgcta aaaaacacaa tacagatata attaatagtt atcatttatg tttgatatta 1260 atcatatgaa tataattaat atgttttatt gtatcgatta ttgttgatat taatgtaatt 1320 actactaata cataacaaat ataactaatg gttatggctc agtaactaag gtaagatata 1380 agctacactg gtaaagaaag atcaatattg cttcagagta cactgaagta aatgaataac 1440 ttaaccggtc taggttgtca cttatattta tacgaaactt gatctgtcgc cgcaattcaa 1500 gcttcgtgag gctccggtgc ccgtcagtga cctgctatag aaacttgatc tgtcgccgca 1560 attcaagctt cgtgaggctc cggtgcccgt cagtgacctg ctatactctg aaatcgataa 1620 tatatggtag ggttcatagc cagagtaacc ttttttttta atttttattt tattttattt 1680 ttgagtcggg cgcgcaaaaa tgaagtgaag ttcctatact ttctagatta attaagaaga 1740 ctt 1743 <210> 390 <211> 1818 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 390 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagatgaccg agtacaagcc 240 cacggtgcgc ctcgccaccc gcgacgacgt ccccagggcc gtacgcaccc tcgccgccgc 300 gttcgccgac taccccgcca cgcgccacac cgtcgatccg gaccgccaca tcgagcgggt 360 caccgagctg caagaactct tcctcacgcg cgtcgggctc gatataggta aggtatgggt 420 ggcggacgac ggcgccgcgg tggcggtctg gaccacgccg gagagcgtcg aagcgggggc 480 ggtgttcgcc gagatcggcc cgcgcatggc cgagttgagc ggttcccggc tggccgcgca 540 gcaacagatg gaaggcctcc tggcgccgca ccggcccaag gagcccgcgt ggttcctggc 600 caccgtcggc gtgtcgcccg accaccaggg caagggtctg ggcagcgccg tcgtgctccc 660 cggagtggag gcggccgagc gcgccggggt gcccgccttc ctggagacat ccgcgccccg 720 caacctcccc ttctacgagc ggctcggctt caccgtcacc gccgacgtcg aggtgcccga 780 aggaccgcgc acctggtgca tgacccgcaa gcccggtgcc tgattagact ttgagtgatc 840 ttgagccttt cctagttcat cccaccccgc cccagagaga tctttgtgaa ggaaccttac 900 ttctgtggtg tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat 960 ataaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag 1020 attccaacct atggaactga tgaatgggag cagtggtgga atgcctttaa tgaggaaaac 1080 ctgttttgct cagaagaaat gccatctagt gatgatgagg ctactgctga ctctcaacat 1140 tctactcctc caaaaaagaa gagaaaggta gaagatccca aggactttcc ttcagaattg 1200 ctaagttttt tgagtcatgc tgtgtttagt aatagaactc ttgcttgctt tgctatttac 1260 accacaaagg aaaaagctgc actgctatac aagaaaatta tggaaaaata ttctgtaacc 1320 tttataagta ggcataacag ttataatcat aacatactgt tttttcttac tccacacagg 1380 catagagtgt ctgctattaa taactatgct caaaaattgt gtacctttag ctttttaatt 1440 tgtaaagggg ttaataagga atatttgatg tatagtgcct tgactagaga tcataatcag 1500 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 1560 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 1620 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 1680 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct agcttcgtgt 1740 caaggacggt gactgcagtg aataataaaa tgtgtgtttg tccgaaatac gcgttttgag 1800 atttctcgag gaagacat 1818 <210> 391 <211> 1734 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 391 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagatgacgg agtacaagcc 240 cacggtaagg ctggcaactc gcgacgatgt gcctagggcg gtaaggaccc tggcggccgc 300 gttcgccgac tatccggcaa ctcgccacac ggtggatccg gaccggcaca tcgagcgggt 360 aactgagctg caagagctgt tcctgacgag agtaggtctg gacatcggta aggtatgggt 420 ggctgatgat ggtgcggcgg tggcggtatg gaccaccccg gagagcgtcg aagcgggggc 480 ggtgttcgcc gagatcggcc cgcgcatggc cgagttgagc ggttcccggc tggccgcgca 540 gcaacagatg gaaggcctcc tggcgccgca ccggcccaag gagcccgcgt ggttcctggc 600 caccgtcggc gtgtcgcccg accaccaggg caagggtctg ggcagcgccg tcgtgctccc 660 cggagtggag gcggccgagc gcgccggggt gcccgccttc ctggagacat ccgcgccccg 720 caacctcccc ttctacgagc ggctcggctt caccgtcacc gccgacgtcg aggtgcccga 780 aggaccgcgc acctggtgca tgacccgcaa gcccggtgcc tgattagact ttgagtgatc 840 ttgagccttt cctagttcat cccaccccgc cccagagaga tctttgtgaa ggaaccttac 900 ttctgtggtg tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat 960 ataaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag 1020 attccaacct atggaactga tgaatgggag cagtggtgga atgcctttaa tgaggaaaac 1080 ctgttttgct cagaagaaat gccatctagt gatgatgagg ctactgctga ctctcaacat 1140 tctactcctc caaaaaagaa gagaaaggta gaagatccca aggactttcc ttcagaattg 1200 ctaagttttt tgagtcatgc tgtgtttagt aatagaactc ttgcttgctt tgctatttac 1260 accacaaagg aaaaagctgc actgctatac aagaaaatta tggaaaaata ttctgtaacc 1320 tttataagta ggcataacag ttataatcat aacatactgt tttttcttac tccacacagg 1380 catagagtgt ctgctattaa taactatgct caaaaattgt gtacctttag ctttttaatt 1440 tgtaaagggg ttaataagga atatttgatg tatagtgcct tgactagaga tcataatcag 1500 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 1560 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 1620 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 1680 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgggaag acat 1734 <210> 392 <211> 1818 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 392 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagatgacgg agtacaagcc 240 cacggtaagg ctggcaactc gcgacgatgt gcctagggcg gtaaggaccc tggcggccgc 300 gttcgccgac tatccggcaa ctcgccacac ggtggatccg gaccggcaca tcgagcgggt 360 aactgagctg caagagctgt tccttactcg ggtaggtctg gatataggta aggtatgggt 420 ggctgatgat ggtgcggcgg tggcggtatg gaccacccca gaaagtgtgg aggcgggtgc 480 ggtgttcgcg gagatcgggc cacgtatggc cgagctgtca ggttccaggt tagctgcaca 540 gcagcagatg gaaggtctgt tggccccgca ccggccgaag gagcccgcgt ggttcctggc 600 aacggtaggg gtaagtccag accaccaagg taagggtctg ggaagtgcgg tggtgttgcc 660 aggtgtggag gcggcagagc gggcgggtgt gcctgctttc ctcgagacta gcgccccgag 720 gaatctgcct ttctacgaaa gactcggttt cacggtaact gccgatgtgg aggtacctga 780 aggacctcgg acctggtgca tgacacgcaa gccaggtgcg tgattagact ttgagtgatc 840 ttgagccttt cctagttcat cccaccccgc cccagagaga tctttgtgaa ggaaccttac 900 ttctgtggtg tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat 960 ataaaatttt taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag 1020 attccaacct atggaactga tgaatgggag cagtggtgga atgcctttaa tgaggaaaac 1080 ctgttttgct cagaagaaat gccatctagt gatgatgagg ctactgctga ctctcaacat 1140 tctactcctc caaaaaagaa gagaaaggta gaagatccca aggactttcc ttcagaattg 1200 ctaagttttt tgagtcatgc tgtgtttagt aatagaactc ttgcttgctt tgctatttac 1260 accacaaagg aaaaagctgc actgctatac aagaaaatta tggaaaaata ttctgtaacc 1320 tttataagta ggcataacag ttataatcat aacatactgt tttttcttac tccacacagg 1380 catagagtgt ctgctattaa taactatgct caaaaattgt gtacctttag ctttttaatt 1440 tgtaaagggg ttaataagga atatttgatg tatagtgcct tgactagaga tcataatcag 1500 ccataccaca tttgtagagg ttttacttgc tttaaaaaac ctcccacacc tccccctgaa 1560 cctgaaacat aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg 1620 ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc 1680 tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggatct agcttcgtgt 1740 caaggacggt gactgcagtg aataataaaa tgtgtgtttg tccgaaatac gcgttttgag 1800 atttctcgag gaagacat 1818 <210> 393 <211> 2011 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 393 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga 420 ccgagtacaa gcccacggtg cgcctcgcca cccgcgacga cgtccccagg gccgtacgca 480 ccctcgccgc cgcgttcgcc gactaccccg ccacgcgcca caccgtcgat ccggaccgcc 540 acatcgagcg ggtcaccgag ctgcaagaac tcttcctcac gcgcgtcggg ctcgatatag 600 gtaaggtatg ggtggcggac gacggcgccg cggtggcggt ctggaccacg ccggagagcg 660 tcgaagcggg ggcggtgttc gccgagatcg gcccgcgcat ggccgagttg agcggttccc 720 ggctggccgc gcagcaacag atggaaggcc tcctggcgcc gcaccggccc aaggagcccg 780 cgtggttcct ggccaccgtc ggcgtgtcgc ccgaccacca gggcaagggt ctgggcagcg 840 ccgtcgtgct ccccggagtg gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga 900 catccgcgcc ccgcaacctc cccttctacg agcggctcgg cttcaccgtc accgccgacg 960 tcgaggtgcc cgaaggaccg cgcacctggt gcatgacccg caagcccggt gcctgattag 1020 actttgagtg atcttgagcc tttcctagtt catcccaccc cgccccagag agatctttgt 1080 gaaggaacct tacttctgtg gtgtgacata attggacaaa ctacctacag agatttaaag 1140 ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt 1200 ttgtgtattt tagattccaa cctatggaac tgatgaatgg gagcagtggt ggaatgcctt 1260 taatgaggaa aacctgtttt gctcagaaga aatgccatct agtgatgatg aggctactgc 1320 tgactctcaa cattctactc ctccaaaaaa gaagagaaag gtagaagatc ccaaggactt 1380 tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa ctcttgcttg 1440 ctttgctatt tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa ttatggaaaa 1500 atattctgta acctttataa gtaggcataa cagttataat cataacatac tgttttttct 1560 tactccacac aggcatagag tgtctgctat taataactat gctcaaaaat tgtgtacctt 1620 tagcttttta atttgtaaag gggttaataa ggaatatttg atgtatagtg ccttgactag 1680 agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 1740 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 1800 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 1860 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga 1920 tctagcttcg tgtcaaggac ggtgactgca gtgaataata aaatgtgtgt ttgtccgaaa 1980 tacgcgtttt gagatttctc gaggaagaca t 2011 <210> 394 <211> 2011 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 394 tagtcttcca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg 60 gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg 120 tcattggcga aaacacgcag atgcagtcgg ggcggcgcgg tcccaggtcc acttcgcata 180 ttaaggtgac gcgtgtggcc tcgaacacag agcgactctg cagggacaca agacaggctt 240 gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag 300 acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac 360 ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga 420 ccgagtacaa gcccacggtg cgcctcgcca cccgcgacga cgtccccagg gccgtacgca 480 ccctcgccgc cgcgttcgcc gactaccccg ccacgcgcca caccgtcgat ccggaccgcc 540 acatcgagcg ggtcaccgag ctgcaagaac tcttcctcac gcgcgtcggg ctcgatatag 600 gtaaggtatg ggtggcggac gacggcgccg cggtggcggt ctggaccacg ccggagagcg 660 tcgaagcggg ggcggtgttc gccgagatcg gcccgcgcat ggccgagttg agcggttccc 720 ggctggccgc gcagcaacag atggaaggcc tcctggcgcc gcaccggccc aaggagcccg 780 cgtggttcct ggccaccgtc ggcgtgtcgc ccgaccacca gggcaagggt ctgggcagcg 840 ccgtcgtgct ccccggagtg gaggcggccg agcgcgccgg ggtgcccgcc ttcctggaga 900 catccgcgcc ccgcaacctc cccttctacg agcggctcgg cttcaccgtc accgccgacg 960 tcgaggtgcc cgaaggaccg cgcacctggt gcatgacccg caagcccggt gcctgattag 1020 actttgagtg atcttgagcc tttcctagtt catcccaccc cgccccagag agatctttgt 1080 gaaggaacct tacttctgtg gtgtgacata attggacaaa ctacctacag agatttaaag 1140 ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt 1200 ttgtgtattt tagattccaa cctatggaac tgatgaatgg gagcagtggt ggaatgcctt 1260 taatgaggaa aacctgtttt gctcagaaga aatgccatct agtgatgatg aggctactgc 1320 tgactctcaa cattctactc ctccaaaaaa gaagagaaag gtagaagatc ccaaggactt 1380 tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa ctcttgcttg 1440 ctttgctatt tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa ttatggaaaa 1500 atattctgta acctttataa gtaggcataa cagttataat cataacatac tgttttttct 1560 tactccacac aggcatagag tgtctgctat taataactat gctcaaaaat tgtgtacctt 1620 tagcttttta atttgtaaag gggttaataa ggaatatttg atgtatagtg ccttgactag 1680 agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 1740 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 1800 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 1860 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgga 1920 tctagcttcg tgtcaaggac ggtgactgca gtgaataata aaatgtgtgt ttgtccgaaa 1980 tacgcgtttt gagatttctc gaggaagaca t 2011 <210> 395 <211> 1344 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 395 tagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 gaggctggga aggggtgggt ccgggggcgg gctcaggggc gggctcaggg gcggggcggg 420 cgcccgaagg tcctccggag gcccggcatt ctgcacgctt caaaagcgca cgtctgccgc 480 gctgttctcc tcttcctcat ctccgggcct ttcgtccgcc accatgaccg agtacaagcc 540 cacggtgcgc ctcgccaccc gcgacgacgt ccccagggcc gtacgcaccc tcgccgccgc 600 gttcgccgac taccccgcca cgcgccacac cgtcgatccg gaccgccaca tcgagcgggt 660 caccgagctg caagaactct tcctcacgcg cgtcgggctc gacatcggca aggtgtgggt 720 cgcggacgac ggcgccgcgg tggcggtctg gaccacgccg gagagcgtcg aagcgggggc 780 ggtgttcgcc gagatcggcc cgcgcatggc cgagttgagc ggttcccggc tggccgcgca 840 gcaacagatg gaaggcctcc tggcgccgca ccggcccaag gagcccgcgt ggttcctggc 900 caccgtcggc gtgtcgcccg accaccaggg caagggtctg ggcagcgccg tcgtgctccc 960 cggagtggag gcggccgagc gcgccggggt gcccgccttc ctggagacat ccgcgccccg 1020 caacctcccc ttctacgagc ggctcggctt caccgtcacc gccgacgtcg aggtgcccga 1080 aggaccgcgc acctggtgca tgacccgcaa gcccggtgcc tgatgactcg ctttcttgct 1140 gtccaatttc tattaaaggt tcctttgttc cctaagtcca actactaaac tgggggatat 1200 tatgaagggc cttgagcatc tggattctgc ctaataaaaa acatttattt tcattgcaat 1260 gatgtattta aattatttct gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat 1320 ttaaaacata aagaaagaag acac 1344 <210> 396 <211> 1469 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 396 ttgtcttcgg cgcgcctcta ccgggtaggg gaggcgcttt tcccaaggca gtctggagca 60 tgcgctttag cagccccgct gggcacttgg cgctacacaa gtggcctctg gcctcgcaca 120 cattccacat ccaccggtag gcgccaaccg gctccgttct ttggtggccc cttcgcgcca 180 ccttctactc ctcccctagt caggaagttc ccccccgccc cgcagctcgc gtcgtgcagg 240 acgtgacaaa tggaagtagc acgactcact agtctcgtgc agatggacag caccgctgag 300 caatggaagc gggtaggcct ttggggcagc ggccaatagc agctttgctc cttcgctttc 360 tgggctcagg ggcggggcgg gcgcccgaag gtcctccgga ggcccggcat tctgcacgct 420 tcaaaagcgc acgtctgccg cgctgttctc ctcttcctca tctccgggcc tttcgtcaca 480 cccaagctgt ctagagccgc caccatgacc gagtacaagc ccacggtgcg cctcgccacc 540 cgcgacgacg tccccagggc cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc 600 acgcgccaca ccgtcgatcc ggaccgccac atcgagcggg tcaccgagct gcaagaactc 660 ttcctcacgc gcgtcgggct cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg 720 gtggcggtct ggaccacgcc ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc 780 ccgcgcatgg ccgagttgag cggttcccgg ctggccgcgc agcaacagat ggaaggcctc 840 ctggcgccgc accggcccaa ggagcccgcg tggttcctgg ccaccgtcgg cgtgtcgccc 900 gaccaccagg gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag 960 cgcgccgggg tgcccgcctt cctggagaca tccgcgcccc gcaacctccc cttctacgag 1020 cggctcggct tcaccgtcac cgccgacgtc gaggtgcccg aaggaccgcg cacctggtgc 1080 atgacccgca agcccggtgc ctgatggatc cgctcagaca tgataagata cattgatgag 1140 tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat 1200 gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc 1260 attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac 1320 ctctacaaat gtggtaaaat cgataatata tggtagggtt catagccaga gtaacctttt 1380 tttttaattt ttattttatt ttatttttga gtcgggcgcg caaaaatgaa gtgaagttcc 1440 tatactttct agattaatta agaagactt 1469 <210> 397 <211> 2029 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 397 ttgtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat gaccgagtac aagcccacgg tgcgcctcgc cacccgcgac gacgtcccca 720 gggccgtacg caccctcgcc gccgcgttcg ccgactaccc cgccacgcgc cacaccgtcg 780 atccggaccg ccacatcgag cgggtcaccg agctgcaaga actcttcctc acgcgcgtcg 840 ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc cgcggtggcg gtctggacca 900 cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat cggcccgcgc atggccgagt 960 tgagcggttc ccggctggcc gcgcagcaac agatggaagg cctcctggcg ccgcaccggc 1020 ccaaggagcc cgcgtggttc ctggccaccg tcggcgtgtc gcccgaccac cagggcaagg 1080 gtctgggcag cgccgtcgtg ctccccggag tggaggcggc cgagcgcgcc ggggtgcccg 1140 ccttcctgga gacatccgcg ccccgcaacc tccccttcta cgagcggctc ggcttcaccg 1200 tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg gtgcatgacc cgcaagcccg 1260 gtgcctgatg gatccgctca gacatgataa gatacattga tgagtttgga caaaccacaa 1320 ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg 1380 taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 1440 aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta 1500 aaatcgataa tatatggtag ggttcatagc cagagtaacc ttttttttta atttttattt 1560 tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag ttcctatact ttctagatag 1620 actctgggta gaatgttctg tttcctgtaa tataaaatca taaagtgatg atattatcaa 1680 gtgaaaagga aatgtggtac cttaatcttt ccacatcaag ccaatatcat gctgaaggcc 1740 agagaatctt ttttgctaaa aaacacaata cagatataat taatagttat catttatgtt 1800 tgatattaat catatgaata taattaatat gttttattgt atcgattatt gttgatatta 1860 atgtaattac tactaataca taacaaatat aactaatggt tatggctcag taactaaggt 1920 aagatataag ctacactggt aaagaaagat caatattgct tcagagtaca ctgaagtaaa 1980 tgaataactt aaccggtcta ggttgtcact tatatttata cgaagactt 2029 <210> 398 <211> 1508 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 398 ttgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 tcaggcaccg ggcttgcggg tcatgcacca ggtgcgcggt ccttcgggca cctcgacgtc 300 ggcggtgacg gtgaagccga gccgctcgta gaaggggagg ttgcggggcg cggatgtctc 360 caggaaggcg ggcaccccgg cgcgctcggc cgcctccact ccggggagca cgacggcgct 420 gcccagaccc ttgccctggt ggtcgggcga cacgccgacg gtggccagga accacgcggg 480 ctccttgggc cggtgcggcg ccaggaggcc ttccatctgt tgctgcgcgg ccagccggga 540 accgctcaac tcggccatgc gcgggccgat ctcggcgaac accgcccccg cttcgacgct 600 ctccggcgtg gtccagaccg ccaccgcggc gccgtcgtcc gcgacccaca ccttgccgat 660 gtcgagcccg acgcgcgtga ggaagagttc ttgcagctcg gtgacccgct cgatgtggcg 720 gtccggatcg acggtgtggc gcgtggcggg gtagtcggcg aacgcggcgg cgagggtgcg 780 tacggccctg gggacgtcgt cgcgggtggc gaggcgcacc gtgggcttgt actcggtcat 840 gtgaagtgtc ccagcctgtt tatctacggc ttaaaaagtg ttcgagggga aaataggttg 900 cgcgagatta tagagatctg gcgcactaaa aaccagtatt tcacatgagt ccgcgtcttt 960 ttacgcactg cctctccctg acgcgggata aagtggtatt ctcaaacata tctcgcaagc 1020 ctgtcttgtg tccaagcttg acgaaaggcc cggagatgag gaagaggaga acagcgcggc 1080 agacgtgcgc ttttgaagcg tgcagaatgc cgggcctccg gaggaccttc gggcgcccgc 1140 cccgcccctg agcccagaaa gcgaaggagc aaagctgcta ttggccgctg ccccaaaggc 1200 ctacccgctt ccattgctca gcggtgctgt ccatctgcac gagactagtg agtcgtgcta 1260 cttccatttg tcacgtcctg cacgacgcga gctgcggggc gggggggaac ttcctgacta 1320 ggggaggagt agaaggtggc gcgaaggggc caccaaagaa cggagccggt tggcgcctac 1380 cggtggatgt ggaatgtgtg cgaggccaga ggccacttgt gtagcgccaa gtgcccagcg 1440 gggctgctaa agcgcatgct ccagactgcc ttgggaaaag cgcctcccct acccggtaga 1500 gaagactt 1508 <210> 399 <211> 1337 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 399 gttttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 60 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 120 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 180 ctttaataga aattggacag caagaaagcg agttatcagg caccgggctt gcgggtcatg 240 caccaggtgc gcggtccttc gggcacctcg acgtcggcgg tgacggtgaa gccgagccgc 300 tcgtagaagg ggaggttgcg gggcgcggat gtctccagga aggcgggcac cccggcgcgc 360 tcggccgcct ccactccggg gagcacgacg gcgctgccca gacccttgcc ctggtggtcg 420 ggcgacacgc cgacggtggc caggaaccac gcgggctcct tgggccggtg cggcgccagg 480 aggccttcca tctgttgctg cgcggccagc cgggaaccgc tcaactcggc catgcgcggg 540 ccgatctcgg cgaacaccgc ccccgcttcg acgctctccg gcgtggtcca gaccgccacc 600 gcggcgccgt cgtccgcgac ccacaccttg ccgatgtcga gcccgacgcg cgtgaggaag 660 agttcttgca gctcggtgac ccgctcgatg tggcggtccg gatcgacggt gtggcgcgtg 720 gcggggtagt cggcgaacgc ggcggcgagg gtgcgtacgg ccctggggac gtcgtcgcgg 780 gtggcgaggc gcaccgtggg cttgtactcg gtcatggtgg cgacgtgcgc tccggaggct 840 tgcagaatgc ggaacaccgc gcgggcagga acagggccca cactaccgcc ccacaccccg 900 cctcccgcac cgccccttcc cggccgctgc tctcagaaag cgaaggagca aagctgctat 960 tggccgctgc cccaaaggcc tacccgcttc cattgctcag cggtgctgtc catctgcacg 1020 agactagtga gtcgtgctac ttccatttgt cacgtcctgc acgacgcgag ctgcggggcg 1080 ggggggaact tcctgactag gggaggagta gaaggtggcg cgaaggggcc accaaagaac 1140 ggagccggtt ggcgcctacc ggtggatgtg gaatgtgtgc gaggccagag gccacttgtg 1200 tagcgccaag tgcccagcgg ggctgctaaa gcgcatgctc cagactgcct tgggaaaagc 1260 gcctccccta cccggtagag aaacttgatc tgtcgccgca attcaaactt cgtgaggctc 1320 cggtgcccgt cagtgta 1337 <210> 400 <211> 1349 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 400 gtgtcttctt tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtt atcaggcacc gggcttgcgg 240 gtcatgcacc aggtgcgcgg tccttcgggc acctcgacgt cggcggtgac ggtgaagccg 300 agccgctcgt agaaggggag gttgcggggc gcggatgtct ccaggaaggc gggcaccccg 360 gcgcgctcgg ccgcctccac tccggggagc acgacggcgc tgcccagacc cttgccctgg 420 tggtcgggcg acacgccgac ggtggccagg aaccacgcgg gctccttggg ccggtgcggc 480 gccaggaggc cttccatctg ttgctgcgcg gccagccggg aaccgctcaa ctcggccatg 540 cgcgggccga tctcggcgaa caccgccccc gcttcgacgc tctccggcgt ggtccagacc 600 gccaccgcgg cgccgtcgtc cgcgacccac accttgccga tgtcgagccc gacgcgcgtg 660 aggaagagtt cttgcagctc ggtgacccgc tcgatgtggc ggtccggatc gacggtgtgg 720 cgcgtggcgg ggtagtcggc gaacgcggcg gcgagggtgc gtacggccct ggggacgtcg 780 tcgcgggtgg cgaggcgcac cgtgggcttg tactcggtca tggtggcgac gtgcgctccg 840 gaggcttgca gaatgcggaa caccgcgcgg gcaggaacag ggcccacact accgccccac 900 accccgcctc ccgcaccgcc ccttcccggc cgctgctctc agaaagcgaa ggagcaaagc 960 tgctattggc cgctgcccca aaggcctacc cgcttccatt gctcagcggt gctgtccatc 1020 tgcacgagac tagtgagtcg tgctacttcc atttgtcacg tcctgcacga cgcgagctgc 1080 ggggcggggg ggaacttcct gactagggga ggagtagaag gtggcgcgaa ggggccacca 1140 aagaacggag ccggttggcg cctaccggtg gatgtggaat gtgtgcgagg ccagaggcca 1200 cttgtgtagc gccaagtgcc cagcggggct gctaaagcgc atgctccaga ctgccttggg 1260 aaaagcgcct cccctacccg gtagagaaac ttgatctgtc gccgcaattc aaacttcgtg 1320 aggctccggt gcccgtcagt ggaagacta 1349 <210> 401 <211> 1349 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 401 gtgtcttctt tctttatgtt ttaaatgcac tgatctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtt atcaggcacc gggcttgcgg 240 gtcatgcacc aggtgcgcgg tccttcgggc acctcgacgt cggcggtgac ggtgaagccg 300 agccgctcgt agaaggggag gttgcggggc gcggatgtct ccaggaaggc gggcaccccg 360 gcgcgctcgg ccgcctccac tccggggagc acgacggcgc tgcccagacc cttgccctgg 420 tggtcgggcg acacgccgac ggtggccagg aaccacgcgg gctccttggg ccggtgcggc 480 gccaggaggc cttccatctg ttgctgcgcg gccagccggg aaccgctcaa ctcggccatg 540 cgcgggccga tctcggcgaa caccgccccc gcttcgacgc tctccggcgt ggtccagacc 600 gccaccgcgg cgccgtcgtc cgcgacccac accttgccga tgtcgagccc gacgcgcgtg 660 aggaagagtt cttgcagctc ggtgacccgc tcgatgtggc ggtccggatc gacggtgtgg 720 cgcgtggcgg ggtagtcggc gaacgcggcg gcgagggtgc gtacggccct ggggacgtcg 780 tcgcgggtgg cgaggcgcac cgtgggcttg tactcggtca tggtggcgac gtgcgctccg 840 gaggcttgca gaatgcggaa caccgcgcgg gcaggaacag ggcccacact accgccccac 900 accccgcctc ccgcaccgcc ccttcccggc cgctgctctc agaaagcgaa ggagcaaagc 960 tgctattggc cgctgcccca aaggcctacc cgcttccatt gctcagcggt gctgtccatc 1020 tgcacgagac tagtgagtcg tgctacttcc atttgtcacg tcctgcacga cgcgagctgc 1080 ggggcggggg ggaacttcct gactagggga ggagtagaag gtggcgcgaa ggggccacca 1140 aagaacggag ccggttggcg cctaccggtg gatgtggaat gtgtgcgagg ccagaggcca 1200 cttgtgtagc gccaagtgcc cagcggggct gctaaagcgc atgctccaga ctgccttggg 1260 aaaagcgcct cccctacccg gtagagaaac ttgatctgtc gccgcaattc aaacttcgtg 1320 aggctccggt gcccgtcagt ggaagacta 1349 <210> 402 <211> 2075 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 402 ttgtcttcgg cgcgccaagt ttccagagct ttcgaggaag gtttcttcaa ctcaaattca 60 tccgcctgat aattttctta tattttccta aagaaggaag agaagcgcat agaggagaag 120 ggaaataatt ttttaggagc ctttcttacg gctatgagga atttggggct cagttgaaaa 180 gcctaaactg cctctcggga ggttgggcgc ggcgaactac tttcagcggc gcacgcagac 240 ggcgtctacg tgaggggtga taagtgacgc aacactcgtt gcataaattt gcgctccgcc 300 agcccggagc atttaggggc ggttggcttt gttgggtgag cttgtttgtg tccctgtggg 360 tggacgtggt tggtgattgg caggatcctg gtatccgcta caggtactgg cccacagccg 420 taaagagctg cgggggcgtg agagggggga atgggtgagg tcaagctgga ggcttcttgg 480 ggttgggtgg gccgctgagg ggaggggagg gcgaggtgac gcgacacccg gcctttctgg 540 gagagtgggc cttgttgacc taaggggggc gagggcagtt ggcacgcgca cgcgccgaca 600 gaaactaaca gacattaacc aacagcgatt ccgtcgcgtt tacttgggag gaaggcggaa 660 aagaggtagt ttgtgtggct tctggaaacc ctaaatttgg aatcccagta tgagaatggt 720 gtcccttctt gtgtttcaat gggattttta cttcgcgagt cttgtgggtt tggttttgtt 780 ttcagtttgc ctaacaccgt gcttaggttt gaggcagatt ggagttcggt cgggggagtt 840 tgaatatccg gaacagttag tggggaaagc tgtggacgct tggtaagaga gcgctctgga 900 ttttccgctg ttgacgttga aaccttgaat gacgaatttc gtattaagtg acttagcctt 960 gtaaaattga ggggaggctt gcggaatatt aacgtattta aggcattttg aaggaatagt 1020 tgctaatttt gaagaatatt aggtgtaaaa gcaagaaata caatgatcct gaggtgacac 1080 gcttatgttt tacttttaaa ctaggtcaaa atgaccgagt acaagcccac ggtgcgcctc 1140 gccacccgcg acgacgtccc cagggccgta cgcaccctcg ccgccgcgtt cgccgactac 1200 cccgccacgc gccacaccgt cgatccggac cgccacatcg agcgggtcac cgagctgcaa 1260 gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc 1320 gccgcggtgg cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag 1380 atcggcccgc gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa 1440 ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggcgtg 1500 tcgcccgacc accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg 1560 gccgagcgcg ccggggtgcc cgccttcctg gagacatccg cgccccgcaa cctccccttc 1620 tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc 1680 tggtgcatga cccgcaagcc cggtgcctga tggatccgct cagacatgat aagatacatt 1740 gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt 1800 tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac 1860 aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag 1920 taaaacctct acaaatgtgg taaaatcgat aatatatggt agggttcata gccagagtaa 1980 cctttttttt taatttttat tttattttat ttttgagtcg ggcgcgcaaa aatgaagtga 2040 agttcctata ctttctagat taattaagaa gactt 2075 <210> 403 <211> 1031 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 403 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 tcagtcctgc tcctcggcca cgaagtgcac gcagttgccg gccgggtcgc gcagggcgaa 300 ctcccgcccc cacggctgct cgccgatctc ggtcatggcc ggcccggagg cgtcccggaa 360 gttcgtggac acgacctccg accactcggc gtacagctcg tccaggccgc gcacccacac 420 ccaggccagg gtgttgtccg gcaccacctg gtcctggacc gcgctgatga acagggtcac 480 gtcgtcccgg accacaccgg cgaagtcgtc ctccacgaag tcccgggaga acccgagccg 540 gtcggtccag aactcgaccg ctccggcgac gtcgcgcgcg gtgagcaccg gaacggcact 600 ggtcaacttg gccatgtgaa gtgtcccagc ctgtttatct acggcttaaa aagtgttcga 660 ggggaaaata ggttgcgcga gattatagag atctggcgca ctaaaaacca gtatttcaca 720 tgagtccgcg tctttttacg cactgcctct ccctgacgcg ggataaagtg gtattctcaa 780 acatatctcg caagcctgtc ttgtgtccct gcagagtcgc tctgtgttcg aggccacacg 840 cgtcacctta atatgcgaag tggacctggg accgcgccgc cccgactgca tctgcgtgtt 900 ttcgccaatg acaagacgct gggcggggtt tgtgtcatca tagaactaaa gacatgcaaa 960 tatatttctt ccggggacac cgccagcaaa cgcgagcaac gggccacggg gatgaagcag 1020 ctggaagact a 1031 <210> 404 <211> 844 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 404 gtgtcttcta ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 60 ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 120 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 180 cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg agcggatcca 240 tcagtcctgc tcctcggcca cgaagtgcac gcagttgccg gccgggtcgc gcagggcgaa 300 ctcccgcccc cacggctgct cgccgatctc ggtcatggcc ggcccggagg cgtcccggaa 360 gttcgtggac acgacctccg accactcggc gtacagctcg tccaggccgc gcacccacac 420 ccaggccagg gtgttgtccg gcaccacctg gtcctggacc gcgctgatga acagggtcac 480 gtcgtcccgg accacaccgg cgaagtcgtc ctccacgaag tcccgggaga acccgagccg 540 gtcggtccag aactcgaccg ctccggcgac gtcgcgcgcg gtgagcaccg gaacggcact 600 ggtcaacttg gccatgccac cctgcagagt cgctctgtgt tcgaggccac acgcgtcacc 660 ttaatatgcg aagtggacct gggaccgcgc cgccccgact gcatctgcgt gttttcgcca 720 atgacaagac gctgggcggg gtttgtgtca tcatagaact aaagacatgc aaatatattt 780 cttccgggga caccgccagc aaacgcgagc aacgggccac ggggatgaag cagctggaag 840 acta 844 <210> 405 <211> 1283 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 405 aagtcttctc taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt 60 agcagccccg ctgggcactt ggcgctacac aagtggcctc tggcctcgca cacattccac 120 atccaccggt aggcgccaac cggctccgtt ctttggtggc cccttcgcgc caccttctac 180 tcctccccta gtcaggaagt tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca 240 aatggaagta gcacgactca ctagtctcgt gcagatggac agcaccgctg agcaatggaa 300 gcgggtaggc ctttggggca gcggccaata gcagctttgc tccttcgctt tctgggctca 360 ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc 420 gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgtca agcttggaca 480 caagacaggc ttgcgagata tgtttgagaa taccacttta tcccgcgtca gggagaggca 540 gtgcgtaaaa agacgcggac tcatgtgaaa tactggtttt tagtgcgcca gatctctata 600 atctcgcgca acctattttc ccctcgaaca ctttttaagc cgtagataaa caggctggga 660 cacttcacat ggccaagttg accagtgccg ttccggtgct caccgcgcgc gacgtcgccg 720 gagcggtcga gttctggacc gaccggctcg ggttctcccg ggacttcgtg gaggacgact 780 tcgccggtgt ggtccgggac gacgtgaccc tgttcatcag cgcggtccag gaccaggtgg 840 tgccggacaa caccctggcc tgggtgtggg tgcgcggcct ggacgagctg tacgccgagt 900 ggtcggaggt cgtgtccacg aacttccggg acgcctccgg gccggccatg accgagatcg 960 gcgagcagcc gtgggggcgg gagttcgccc tgcgcgaccc ggccggcaac tgcgtgcact 1020 tcgtggccga ggagcaggac tgatggatcc gctcagacat gataagatac attgatgagt 1080 ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg 1140 ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca 1200 ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc 1260 tctacaaatg tggtagaaga caa 1283 <210> 406 <211> 1121 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 406 gtgtcttctt tctttatgtt ttaaatgcac tgatctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtc agtcctgctc ctcggccacg 240 aagtgcacgc agttgccggc cgggtcgcgc agggcgaact cccgccccca cggctgctcg 300 ccgatctcgg tcatggccgg cccggaggcg tcccggaagt tcgtggacac gacctccgac 360 cactcggcgt acagctcgtc caggccgcgc acccacaccc aggccagggt gttgtccggc 420 accacctggt cctggaccgc gctgatgaac agggtcacgt cgtcccggac cacaccggcg 480 aagtcgtcct ccacgaagtc ccgggagaac ccgagccggt cggtccagaa ctcgaccgct 540 ccggcgacgt cgcgcgcggt gagcaccgga acggcactgg tcaacttggc catggtggcg 600 acgtgcgctc cggaggcttg cagaatgcgg aacaccgcgc gggcaggaac agggcccaca 660 ctaccgcccc acaccccgcc tcccgcaccg ccccttcccg gccgctgctc tcagaaagcg 720 aaggagcaaa gctgctattg gccgctgccc caaaggccta cccgcttcca ttgctcagcg 780 gtgctgtcca tctgcacgag actagtgagt cgtgctactt ccatttgtca cgtcctgcac 840 gacgcgagct gcggggcggg ggggaacttc ctgactaggg gaggagtaga aggtggcgcg 900 aaggggccac caaagaacgg agccggttgg cgcctaccgg tggatgtgga atgtgtgcga 960 ggccagaggc cacttgtgta gcgccaagtg cccagcgggg ctgctaaagc gcatgctcca 1020 gactgccttg ggaaaagcgc ctcccctacc cggtagagaa acttgatctg tcgccgcaat 1080 tcaaacttcg tgaggctccg gtgcccgtca gtggaagact a 1121 <210> 407 <211> 788 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 407 aagtcttctt aattaatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat 60 ggctgactaa ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc 120 cagaagtagt gaggaggctt ttttggaggt ataggctttt gcaaaatggc caagttgacc 180 agtgccgttc cggtgctcac cgcgcgcgac gtcgccggag cggtcgagtt ctggaccgac 240 cggctcgggt tctcccggga cttcgtggag gacgacttcg ccggtgtggt ccgggacgac 300 gtgaccctgt tcatcagcgc ggtccaggac caggtggtgc cggacaacac cctggcctgg 360 gtgtgggtgc gcggcctgga cgagctgtac gccgagtggt cggaggtcgt gtccacgaac 420 ttccgggacg cctccgggcc ggccatgacc gagatcggcg agcagccgtg ggggcgggag 480 ttcgccctgc gcgacccggc cggcaactgc gtgcacttcg tggccgagga gcaggactga 540 tggatccgct cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg 600 cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt 660 ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag 720 ggggaggtgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taggcgcgcc 780 gaagacaa 788 <210> 408 <211> 2852 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 408 gtgtcttctt tctttatgtt ttaaatgcac tgacctccca cattcccttt ttagtaaaat 60 attcagaaat aatttaaata catcattgca atgaaaataa atgtttttta ttaggcagaa 120 tccagatgct caaggccctt cataatatcc cccagtttag tagttggact tagggaacaa 180 aggaaccttt aatagaaatt ggacagcaag aaagcgagtc actattagtc tttcttctcg 240 tagacttcaa acttatactt gatgcctttt tcctcctgga cctcagagag gacgcctggg 300 tattctggga gaagtttata tttccccaaa tcaatttctg ggaaaaacgt gtcactttca 360 aattcctgca tgatccttgt cacaaagagt ctgaggtggc ctggttgatt catggcttcc 420 tggtaaacag aactgcctcc gactatccaa accatgtcta ctttacttgc caattccggt 480 tgttcaataa gtcttaaggc atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt 540 ggttctttga gttctctact gagaactata ttaattctgt cctttaaagg tcgattcttc 600 tcaggaatgg agaaccaggt tttcctaccc ataatcacca gattctgttt accttccact 660 gaagaggttg tggtcattct ttggaagtac ttgaactcgt tcctgagcgg aggccagggc 720 aagtctccgt tcttgccaat ccccatattt tgggacacgg cgacgatgca gttcaatggt 780 cgaaccattt tgctgtattt aatagtaaaa tatactttag tgtgatgatt gtggtgtgat 840 ccaatggcac aaatccaaca aaagagtaaa taatcgctct attgctcacc ggatggccaa 900 tccaatagct atatggcaac aatctctcaa ttgtcaccat aagcagccag atttggaata 960 aaaggaaaca cggacaccca aagtagtcgg ttccgctgcg gagttgcccg ttacgacaga 1020 ctgcccactg gttcgtgggt atctgctcca cagttaggat tatccgcatt caggggccgg 1080 aggactacta actagctcaa tagactcttc gcaccatgtc tgtattagag cgtcctatgg 1140 gtcaccccat aggcaggccg ccagcgcagc caccgccacg gtcgcccgtg aggaatgcgg 1200 tgactcatcg acctgatcta cactggggaa gtgctgagtg aaacactccg caactttcat 1260 ggtgttacta ggtttttcga agtagttagc cggataacga acgttttctc cttcaaccgc 1320 gtgagcagtc tattgatact cggtccgggg aaacaggagt gcttgatcta gacacggctg 1380 gtgtgccacg cccactattg atcggtatga attgcttcta agtttcagta gggggagggg 1440 tataaaacag gcacacaaag gtaccgtagt accagagtgc tagcgcccag tgggccctgt 1500 gggtgggtac aacccacagg ctgttttaat cagaagaact cgtcaagaag gcgatagaag 1560 gcgatgcgct gcgaatcggg agcggcgata ccgtaaagca cgaggaagcg gtcagcccat 1620 tcgccgccaa gttcctcagc aatatcacgg gtagccaacg ctatgtcctg atagcggtcc 1680 gccacaccca gccggccaca gtcgatgaat ccagaaaagc ggccattttc caccatgata 1740 ttcggcaagc aggcatcgcc atgggtcacg acgagatcct cgccgtcggg catgcgcgcc 1800 ttgagcctgg cgaacagttc ggctggcgcg agcccctgat gttcctcgtc cagatcatcc 1860 tgatcgacaa gaccggcttc catccgagta cgtgctcgct cgatgcgatg tttcgcttgg 1920 tggtcgaatg ggcatgtagc cggatcaagc gtatgcagcc gccgcattgc atcagccatg 1980 atggatactt tctcggcagg agcaaggtga gatgacagga gatcctgccc cggcacttcg 2040 cccaatagca gccagtccct tcccgcttca gtgacaacgt cgagcacagc tgcgcaagga 2100 acgcccgtcg tggccagcca cgatagccgc gctgcctcgt cctgcagttc attcagggca 2160 ccggacaggt cggtcttgac aaaaagaacc gggcgcccct gcgctgacag ccggaacacg 2220 gcggcatcag agcagccgat tgtctgttgt gcccagtcat agccgaatag cctctccacc 2280 caagcggccg gagaaccagc gtgcaatcca tcttgttcaa tcatggtggc gacgtgcgct 2340 ccggaggctt gcagaatgcg gaacaccgcg cgggcaggaa cagggcccac actaccgccc 2400 cacaccccgc ctcccgcacc gccccttccc ggccgctgct ctcagaaagc gaaggagcaa 2460 agctgctatt ggccgctgcc ccaaaggcct acccgcttcc attgctcagc ggtgctgtcc 2520 atctgcacga gactagtgag tcgtgctact tccatttgtc acgtcctgca cgacgcgagc 2580 tgcggggcgg gggggaactt cctgactagg ggaggagtag aaggtggcgc gaaggggcca 2640 ccaaagaacg gagccggttg gcgcctaccg gtggatgtgg aatgtgtgcg aggccagagg 2700 ccacttgtgt agcgccaagt gcccagcggg gctgctaaag cgcatgctcc agactgcctt 2760 gggaaaagcg cctcccctac ccggtagaga aacttgatct gtcgccgcaa ttcaaacttc 2820 gtgaggctcc ggtgcccgtc agtggaagac ta 2852 <210> 409 <211> 2121 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 409 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcactatcag cccttctgcc 240 aaatctggta gctatagttg atgttcgagg cgaagtcttg ggtgaacacc ggcctaaagt 300 tgctcgggat ctcagggaag tacacatctc cttcgggttc gatgtcgatg gtggagatgt 360 gcagagtgtc cacttggtcg atcagtgact tgtagatttc gccccctccg gacacaatga 420 catggtcggt gatcttcttg aggttcgtga gagcgtcctt gatcgaaggg aagatcagca 480 catcctcatt gtcggaagtg aagctggatc tggtcacgac ggcgtatttc cggttcggca 540 gggcacccat ggattcgaaa gtcttgcgac cgacaagcaa ccactggttg taggtgatgg 600 ccttgaacag cagctgctct ccctttgcgg accagggaat atctgggccg ttcccaatca 660 ctccgttctt tgaaatcgcc accatggggc cgggattttc ctccacgtcc ccgcatgtta 720 gcagacttcc cctgccctca gatgtaccga agaactcgtc aagaaggcga tagaaggcga 780 tgcgctgcga atcgggagcg gcgataccgt aaagcacgag gaagcggtca gcccattcgc 840 cgccaagttc ctcagcaata tcacgggtag ccaacgctat gtcctgatag cggtccgcca 900 cacccagccg gccacagtcg atgaatccag aaaagcggcc attttccacc atgatattcg 960 gcaagcaggc atcgccatgg gtcacgacga gatcctcgcc gtcgggcatg cgcgccttga 1020 gcctggcgaa cagttcggct ggcgcgagcc cctgatgttc ctcgtccaga tcatcctgat 1080 cgacaagacc ggcttccatc cgagtacgtg ctcgctcgat gcgatgtttc gcttggtggt 1140 cgaatgggca tgtagccgga tcaagcgtat gcagccgccg cattgcatca gccatgatgg 1200 atactttctc ggcaggagca aggtgagatg acaggagatc ctgccccggc acttcgccca 1260 atagcagcca gtcccttccc gcttcagtga caacgtcgag cacagctgcg caaggaacgc 1320 ccgtcgtggc cagccacgat agccgcgctg cctcgtcctg cagttcattc agggcaccgg 1380 acaggtcggt cttgacaaaa agaaccgggc gcccctgcgc tgacagccgg aacacggcgg 1440 catcagagca gccgattgtc tgttgtgccc agtcatagcc gaatagcctc tccacccaag 1500 cggccggaga accagcgtgc aatccatctt gttcaatcat ggtggcggac gaaaggcccg 1560 gagatgagga agaggagaac agcgcggcag acgtgcgctt ttgaagcgtg cagaatgccg 1620 ggcctccgga ggaccttcgg gcgcccgccc cgcccctgag cccgcccctg agcccgcccc 1680 cggacccacc ccttcccagc ctctgagccc agaaagcgaa ggagcaaagc tgctattggc 1740 cgctgcccca aaggcctacc cgcttccatt gctcagcggt gctgtccatc tgcacgagac 1800 tagtgagtcg tgctacttcc atttgtcacg tcctgcacga cgcgagctgc ggggcggggg 1860 ggaacttcct gactagggga ggagtagaag gtggcgcgaa ggggccacca aagaacggag 1920 ccggttggcg cctaccggtg gatgtggaat gtgtgcgagg ccagaggcca cttgtgtagc 1980 gccaagtgcc cagcggggct gctaaagcgc atgctccaga ctgccttggg aaaagcgcct 2040 cccctacccg gtagagaaac ttgatctgtc gccgcaattc aaacttcgtg aggctccggt 2100 gcccgtcagt gacctgctat a 2121 <210> 410 <211> 2366 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 410 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatta 840 aaacagcctg tgggttgtac ccacccacag ggcccactgg gcgctagcac tctggtacta 900 cggtaccttt gtgtgcctgt tttatacccc tccccctact gaaacttaga agcaattcat 960 accgatcaat agtgggcgtg gcacaccagc cgtgtctaga tcaagcactc ctgtttcccc 1020 ggaccgagta tcaatagact gctcacgcgg ttgaaggaga aaacgttcgt tatccggcta 1080 actacttcga aaaacctagt aacaccatga aagttgcgga gtgtttcact cagcacttcc 1140 ccagtgtaga tcaggtcgat gagtcaccgc attcctcacg ggcgaccgtg gcggtggctg 1200 cgctggcggc ctgcctatgg ggtgacccat aggacgctct aatacagaca tggtgcgaag 1260 agtctattga gctagttagt agtcctccgg cccctgaatg cggataatcc taactgtgga 1320 gcagataccc acgaaccagt gggcagtctg tcgtaacggg caactccgca gcggaaccga 1380 ctactttggg tgtccgtgtt tccttttatt ccaaatctgg ctgcttatgg tgacaattga 1440 gagattgttg ccatatagct attggattgg ccatccggtg agcaatagag cgattattta 1500 ctcttttgtt ggatttgtgc cattggatca caccacaatc atcacactaa agtatatttt 1560 actattaaat acagcaaaat ggttcgacca ttgaactgca tcgtcgccgt gtcccaaaat 1620 atggggattg gcaagaacgg agacttgccc tggcctccgc tcaggaacga gttcaagtac 1680 ttccaaagaa tgaccacaac ctcttcagtg gaaggtaaac agaatctggt gattatgggt 1740 aggaaaacct ggttctccat tcctgagaag aatcgacctt taaaggacag aattaatata 1800 gttctcagta gagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg 1860 gatgatgcct taagacttat tgaacaaccg gaattggcaa gtaaagtaga catggtttgg 1920 atagtcggag gcagttctgt ttaccaggaa gccatgaatc aaccaggcca cctcagactc 1980 tttgtgacaa ggatcatgca ggaatttgaa agtgacacgt ttttcccaga aattgatttg 2040 gggaaatata aacttctccc agaataccca ggcgtcctct ctgaggtcca ggaggaaaaa 2100 ggcatcaagt ataagtttga agtctacgag aagaaagact aatagtgact cgctttcttg 2160 ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat 2220 attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat tttcattgca 2280 atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg aggtcagtgc 2340 atttaaaaca taaagaaaga agacac 2366 <210> 411 <211> 2785 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 411 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gatgaccgag 240 tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccagggccgt acgcaccctc 300 gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgatccgga ccgccacatc 360 gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag 420 gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa 480 gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg 540 gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg 600 ttcctggcca ccgtcggcgt gtcgcccgac caccagggca agggtctggg cagcgccgtc 660 gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacatcc 720 gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag 780 gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgcctg agaaacccgt 840 atacaccgga ccttttctcc cctccctctc cacttacctt tttcccctct tcggcatgaa 900 acaaggatta ttcaagtgga aacgcgattt aatatgcggc tggccaccgc ggaataacgg 960 caattgtgta tctgctggaa gccaagcctg cctagccgat agcccttgac cgggtgtgta 1020 ggatagccca ggaaccagca atacgcgaca ggttatggta gagtagatac ctagccaggg 1080 gcaatgggac tgcattgcat atccctaatg aaccattgag atttctctgg tcattacccg 1140 gtgatggtta ctagaggggg gcctctagta ctagatctat actgcctgat agggtcgcgg 1200 ctggccgacc atgacctgta tagtcagttg atttgagcaa tatggttcga ccattgaact 1260 gcatcgtcgc cgtgtcccaa aatatgggga ttggcaagaa cggagacttg ccctggcctc 1320 cgctcaggaa cgagttcaag tacttccaaa gaatgaccac aacctcttca gtggaaggta 1380 aacagaatct ggtgattatg ggtaggaaaa cctggttctc cattcctgag aagaatcgac 1440 ctttaaagga cagaattaat atagttctca gtagagaact caaagaacca ccacgaggag 1500 ctcattttct tgccaaaagt ttggatgatg ccttaagact tattgaacaa ccggaattgg 1560 caagtaaagt agacatggtt tggatagtcg gaggcagttc tgtttaccag gaagccatga 1620 atcaaccagg ccacctcaga ctctttgtga caaggatcat gcaggaattt gaaagtgaca 1680 cgtttttccc agaaattgat ttggggaaat ataaacttct cccagagtac ccaggtgtgt 1740 taagtgaggt gcaagaggaa aaaggtatca agtacaagtt cgaggtatat gaaaagaagg 1800 attaatggat ccgctcagac atgataagat acattgatga gtttggacaa accacaacta 1860 gaatgcagtg ataattagac tttgagtgat cttgagcctt tcctagttca tcccaccccg 1920 ccccagagag atctttgtga aggaacctta cttctgtggt gtgacataat tggacaaact 1980 acctacagag atttaaagct ctaaggtaaa tataaaattt ttaagtgtat aatgtgttaa 2040 actactgatt ctaattgttt gtgtatttta gattccaacc tatggaactg atgaatggga 2100 gcagtggtgg aatgccttta atgaggaaaa cctgttttgc tcagaagaaa tgccatctag 2160 tgatgatgag gctactgctg actctcaaca ttctactcct ccaaaaaaga agagaaaggt 2220 agaagatccc aaggactttc cttcagaatt gctaagtttt ttgagtcatg ctgtgtttag 2280 taatagaact cttgcttgct ttgctattta caccacaaag gaaaaagctg cactgctata 2340 caagaaaatt atggaaaaat attctgtaac ctttataagt aggcataaca gttataatca 2400 taacatactg ttttttctta ctccacacag gcatagagtg tctgctatta ataactatgc 2460 tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg gttaataagg aatatttgat 2520 gtatagtgcc ttgactagag atcataatca gccataccac atttgtagag gttttacttg 2580 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 2640 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 2700 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 2760 tatcttatca tgtctgggaa gacac 2785 <210> 412 <211> 2222 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 412 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gagatatgtt tgagaatacc actttatccc gcgtcaggga gaggcagtgc 300 gtaaaaagac gcggactcat gtgaaatact ggtttttagt gcgccagatc tctataatct 360 cgcgcaacct attttcccct cgaacacttt ttaagccgta gataaacagg ctgggacact 420 tcacatgacc gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc 480 cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc 540 ggaccgccac atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct 600 cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc 660 ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag 720 cggttcccgg ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa 780 ggagcccgcg tggttcctgg ccaccgtcgg cgtgtcgccc gaccaccagg gcaagggtct 840 gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg tgcccgcctt 900 cctggagaca tccgcgcccc gcaacctccc cttctacgag cggctcggct tcaccgtcac 960 cgccgacgtc gaggtgcccg aaggaccgcg cacctggtgc atgacccgca agcccggtgc 1020 ctgagaaacc cgtatacacc ggaccttttc tcccctccct ctccacttac ctttttcccc 1080 tcttcggcat gaaacaagga ttattcaagt ggaaacgcga tttaatatgc ggctggccac 1140 cgcggaataa cggcaattgt gtatctgctg gaagccaagc ctgcctagcc gatagccctt 1200 gaccgggtgt gtaggatagc ccaggaacca gcaatacgcg acaggttatg gtagagtaga 1260 tacctagcca ggggcaatgg gactgcattg catatcccta atgaaccatt gagatttctc 1320 tggtcattac ccggtgatgg ttactagagg ggggcctcta gtactagatc tatactgcct 1380 gatagggtcg cggctggccg accatgacct gtatagtcag ttgatttgag caatatggtt 1440 cgaccattga actgcatcgt cgccgtgtcc caaaatatgg ggattggcaa gaacggagac 1500 ttgccctggc ctccgctcag gaacgagttc aagtacttcc aaagaatgac cacaacctct 1560 tcagtggaag gtaaacagaa tctggtgatt atgggtagga aaacctggtt ctccattcct 1620 gagaagaatc gacctttaaa ggacagaatt aatatagttc tcagtagaga actcaaagaa 1680 ccaccacgag gagctcattt tcttgccaaa agtttggatg atgccttaag acttattgaa 1740 caaccggaat tggcaagtaa agtagacatg gtttggatag tcggaggcag ttctgtttac 1800 caggaagcca tgaatcaacc aggccacctc agactctttg tgacaaggat catgcaggaa 1860 tttgaaagtg acacgttttt cccagaaatt gatttgggga aatataaact tctcccagaa 1920 tacccaggcg tcctctctga ggtccaggag gaaaaaggca tcaagtataa gtttgaagtc 1980 tacgagaaga aagactaata gtgactcgct ttcttgctgt ccaatttcta ttaaaggttc 2040 ctttgttccc taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg 2100 gattctgcct aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga 2160 atattttact aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaagaagac 2220 ac 2222 <210> 413 <211> 2717 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 413 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gagatatgtt tgagaatacc actttatccc gcgtcaggga gaggcagtgc 300 gtaaaaagac gcggactcat gtgaaatact ggtttttagt gcgccagatc tctataatct 360 cgcgcaacct attttcccct cgaacacttt ttaagccgta gataaacagg ctgggacact 420 tcacatgacc gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc 480 cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc 540 ggaccgccac atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct 600 cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc 660 ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag 720 cggttcccgg ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa 780 ggagcccgcg tggttcctgg ccaccgtcgg cgtgtcgccc gaccaccagg gcaagggtct 840 gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg tgcccgcctt 900 cctggagaca tccgcgcccc gcaacctccc cttctacgag cggctcggct tcaccgtcac 960 cgccgacgtc gaggtgcccg aaggaccgcg cacctggtgc atgacccgca agcccggtgc 1020 ctgagaaacc cgtatacacc ggaccttttc tcccctccct ctccacttac ctttttcccc 1080 tcttcggcat gaaacaagga ttattcaagt ggaaacgcga tttaatatgc ggctggccac 1140 cgcggaataa cggcaattgt gtatctgctg gaagccaagc ctgcctagcc gatagccctt 1200 gaccgggtgt gtaggatagc ccaggaacca gcaatacgcg acaggttatg gtagagtaga 1260 tacctagcca ggggcaatgg gactgcattg catatcccta atgaaccatt gagatttctc 1320 tggtcattac ccggtgatgg ttactagagg ggggcctcta gtactagatc tatactgcct 1380 gatagggtcg cggctggccg accatgacct gtatagtcag ttgatttgag caatatggtt 1440 cgaccattga actgcatcgt cgccgtgtcc caaaatatgg ggattggcaa gaacggagac 1500 ttgccctggc ctccgctcag gaacgagttc aagtacttcc aaagaatgac cacaacctct 1560 tcagtggaag gtaaacagaa tctggtgatt atgggtagga aaacctggtt ctccattcct 1620 gagaagaatc gacctttaaa ggacagaatt aatatagttc tcagtagaga actcaaagaa 1680 ccaccacgag gagctcattt tcttgccaaa agtttggatg atgccttaag acttattgaa 1740 caaccggaat tggcaagtaa agtagacatg gtttggatag tcggaggcag ttctgtttac 1800 caggaagcca tgaatcaacc aggccacctc agactctttg tgacaaggat catgcaggaa 1860 tttgaaagtg acacgttttt cccagaaatt gatttgggga aatataaact tctcccagag 1920 tacccaggtg tgttaagtga ggtgcaagag gaaaaaggta tcaagtacaa gttcgaggta 1980 tatgaaaaga aggattaatg gatccgctca gacatgataa gatacattga tgagtttgga 2040 caaaccacaa ctagaatgca gtgataatta gactttgagt gatcttgagc ctttcctagt 2100 tcatcccacc ccgccccaga gagatctttg tgaaggaacc ttacttctgt ggtgtgacat 2160 aattggacaa actacctaca gagatttaaa gctctaaggt aaatataaaa tttttaagtg 2220 tataatgtgt taaactactg attctaattg tttgtgtatt ttagattcca acctatggaa 2280 ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga aaacctgttt tgctcagaag 2340 aaatgccatc tagtgatgat gaggctactg ctgactctca acattctact cctccacaga 2400 cctggtgacc gtcaggaaga agattcagtg agaggacacg aggtatgtca tggtttttaa 2460 tcaataaata aagaggtttt attcatcgga cagtcgttgt agcctgtaaa agactcgccc 2520 cggagggggt tcccccgatg tgaggggcat gcagtagtat ggtgtcctga gtgtctcgga 2580 tgcgtccttg aactcgcact ctaccgccgt gggggttaat aaagttttgc tgcgccggta 2640 gggggggagg ccgaggataa taaagttgct acgtactggt tgaagtctaa caatctctcg 2700 gggggatccg aagacac 2717 <210> 414 <211> 2553 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 414 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gagatatgtt tgagaatacc actttatccc gcgtcaggga gaggcagtgc 300 gtaaaaagac gcggactcat gtgaaatact ggtttttagt gcgccagatc tctataatct 360 cgcgcaacct attttcccct cgaacacttt ttaagccgta gataaacagg ctgggacact 420 tcacatgacc gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg tccccagggc 480 cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca ccgtcgatcc 540 ggaccgccac atcgagcggg tcaccgagct gcaagaactc ttcctcacgc gcgtcgggct 600 cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct ggaccacgcc 660 ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg ccgagttgag 720 cggttcccgg ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc accggcccaa 780 ggagcccgcg tggttcctgg ccaccgtcgg cgtgtcgccc gaccaccagg gcaagggtct 840 gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg tgcccgcctt 900 cctggagaca tccgcgcccc gcaacctccc cttctacgag cggctcggct tcaccgtcac 960 cgccgacgtc gaggtgcccg aaggaccgcg cacctggtgc atgacccgca agcccggtgc 1020 ctgattaaaa cagcctgtgg gttgtaccca cccacagggc ccactgggcg ctagcactct 1080 ggtactacgg tacctttgtg tgcctgtttt atacccctcc ccctactgaa acttagaagc 1140 aattcatacc gatcaatagt gggcgtggca caccagccgt gtctagatca agcactcctg 1200 tttccccgga ccgagtatca atagactgct cacgcggttg aaggagaaaa cgttcgttat 1260 ccggctaact acttcgaaaa acctagtaac accatgaaag ttgcggagtg tttcactcag 1320 cacttcccca gtgtagatca ggtcgatgag tcaccgcatt cctcacgggc gaccgtggcg 1380 gtggctgcgc tggcggcctg cctatggggt gacccatagg acgctctaat acagacatgg 1440 tgcgaagagt ctattgagct agttagtagt cctccggccc ctgaatgcgg ataatcctaa 1500 ctgtggagca gatacccacg aaccagtggg cagtctgtcg taacgggcaa ctccgcagcg 1560 gaaccgacta ctttgggtgt ccgtgtttcc ttttattcca aatctggctg cttatggtga 1620 caattgagag attgttgcca tatagctatt ggattggcca tccggtgagc aatagagcga 1680 ttatttactc ttttgttgga tttgtgccat tggatcacac cacaatcatc acactaaagt 1740 atattttact attaaataca gcaaaatggt tcgaccattg aactgcatcg tcgccgtgtc 1800 ccaaaatatg gggattggca agaacggaga cttgccctgg cctccgctca ggaacgagtt 1860 caagtacttc caaagaatga ccacaacctc ttcagtggaa ggtaaacaga atctggtgat 1920 tatgggtagg aaaacctggt tctccattcc tgagaagaat cgacctttaa aggacagaat 1980 taatatagtt ctcagtagag aactcaaaga accaccacga ggagctcatt ttcttgccaa 2040 aagtttggat gatgccttaa gacttattga acaaccggaa ttggcaagta aagtagacat 2100 ggtttggata gtcggaggca gttctgttta ccaggaagcc atgaatcaac caggccacct 2160 cagactcttt gtgacaagga tcatgcagga atttgaaagt gacacgtttt tcccagaaat 2220 tgatttgggg aaatataaac ttctcccaga atacccaggc gtcctctctg aggtccagga 2280 ggaaaaaggc atcaagtata agtttgaagt ctacgagaag aaagactaat agtgactcgc 2340 tttcttgctg tccaatttct attaaaggtt cctttgttcc ctaagtccaa ctactaaact 2400 gggggatatt atgaagggcc ttgagcatct ggattctgcc taataaaaaa catttatttt 2460 cattgcaatg atgtatttaa attatttctg aatattttac taaaaaggga atgtgggagg 2520 tcagtgcatt taaaacataa agaaagaaga cac 2553 <210> 415 <211> 2718 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 415 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gacaccatgg ttgagaatac cactttatcc cgcgtcaggg agaggcagtg 300 cgtaaaaaga cgcggactca tgtgaaatac tggtttttag tgcgccagat ctctataatc 360 tcgcgcaacc tattttcccc tcgaacactt tttaagccgt agataaacag gctgggacac 420 ttcacatgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac gtccccaggg 480 ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac accgtcgatc 540 cggaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc 600 tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc 660 cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga 720 gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg caccggccca 780 aggagcccgc gtggttcctg gccaccgtcg gcgtgtcgcc cgaccaccag ggcaagggtc 840 tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg gtgcccgcct 900 tcctggagac atccgcgccc cgcaacctcc ccttctacga gcggctcggc ttcaccgtca 960 ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc aagcccggtg 1020 cctgagaaac ccgtatacac cggacctttt ctcccctccc tctccactta cctttttccc 1080 ctcttcggca tgaaacaagg attattcaag tggaaacgcg atttaatatg cggctggcca 1140 ccgcggaata acggcaattg tgtatctgct ggaagccaag cctgcctagc cgatagccct 1200 tgaccgggtg tgtaggatag cccaggaacc agcaatacgc gacaggttat ggtagagtag 1260 atacctagcc aggggcaatg ggactgcatt gcatatccct aatgaaccat tgagatttct 1320 ctggtcatta cccggtgatg gttactagag gggggcctct agtactagat ctatactgcc 1380 tgatagggtc gcggctggcc gaccatgacc tgtatagtca gttgatttga gcaatatggt 1440 tcgaccattg aactgcatcg tcgccgtgtc ccaaaatatg gggattggca agaacggaga 1500 cttgccctgg cctccgctca ggaacgagtt caagtacttc caaagaatga ccacaacctc 1560 ttcagtggaa ggtaaacaga atctggtgat tatgggtagg aaaacctggt tctccattcc 1620 tgagaagaat cgacctttaa aggacagaat taatatagtt ctcagtagag aactcaaaga 1680 accaccacga ggagctcatt ttcttgccaa aagtttggat gatgccttaa gacttattga 1740 acaaccggaa ttggcaagta aagtagacat ggtttggata gtcggaggca gttctgttta 1800 ccaggaagcc atgaatcaac caggccacct cagactcttt gtgacaagga tcatgcagga 1860 atttgaaagt gacacgtttt tcccagaaat tgatttgggg aaatataaac ttctcccaga 1920 gtacccaggt gtgttaagtg aggtgcaaga ggaaaaaggt atcaagtaca agttcgaggt 1980 atatgaaaag aaggattaat ggatccgctc agacatgata agatacattg atgagtttgg 2040 acaaaccaca actagaatgc agtgataatt agactttgag tgatcttgag cctttcctag 2100 ttcatcccac cccgccccag agagatcttt gtgaaggaac cttacttctg tggtgtgaca 2160 taattggaca aactacctac agagatttaa agctctaagg taaatataaa atttttaagt 2220 gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga 2280 actgatgaat gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa 2340 gaaatgccat ctagtgatga tgaggctact gctgactctc aacattctac tcctccacag 2400 acctggtgac cgtcaggaag aagattcagt gagaggacac gaggtatgtc atggttttta 2460 atcaataaat aaagaggttt tattcatcgg acagtcgttg tagcctgtaa aagactcgcc 2520 ccggaggggg ttcccccgat gtgaggggca tgcagtagta tggtgtcctg agtgtctcgg 2580 atgcgtcctt gaactcgcac tctaccgccg tgggggttaa taaagttttg ctgcgccggt 2640 agggggggag gccgaggata ataaagttgc tacgtactgg ttgaagtcta acaatctctc 2700 ggggggatcc gaagacac 2718 <210> 416 <211> 2718 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 416 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gccaccatgg ttgagaatac cactttatcc cgcgtcaggg agaggcagtg 300 cgtaaaaaga cgcggaacca tgtgaaatac tggtttttag tgcgccagat ctctataatc 360 tcgcgcaacc tattttcccc tcgaacactt tttaagccgt agataaacag gctgggacac 420 ttcacatgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac gtccccaggg 480 ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac accgtcgatc 540 cggaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc 600 tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc 660 cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga 720 gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg caccggccca 780 aggagcccgc gtggttcctg gccaccgtcg gcgtgtcgcc cgaccaccag ggcaagggtc 840 tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg gtgcccgcct 900 tcctggagac atccgcgccc cgcaacctcc ccttctacga gcggctcggc ttcaccgtca 960 ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc aagcccggtg 1020 cctgagaaac ccgtatacac cggacctttt ctcccctccc tctccactta cctttttccc 1080 ctcttcggca tgaaacaagg attattcaag tggaaacgcg atttaatatg cggctggcca 1140 ccgcggaata acggcaattg tgtatctgct ggaagccaag cctgcctagc cgatagccct 1200 tgaccgggtg tgtaggatag cccaggaacc agcaatacgc gacaggttat ggtagagtag 1260 atacctagcc aggggcaatg ggactgcatt gcatatccct aatgaaccat tgagatttct 1320 ctggtcatta cccggtgatg gttactagag gggggcctct agtactagat ctatactgcc 1380 tgatagggtc gcggctggcc gaccatgacc tgtatagtca gttgatttga gcaatatggt 1440 tcgaccattg aactgcatcg tcgccgtgtc ccaaaatatg gggattggca agaacggaga 1500 cttgccctgg cctccgctca ggaacgagtt caagtacttc caaagaatga ccacaacctc 1560 ttcagtggaa ggtaaacaga atctggtgat tatgggtagg aaaacctggt tctccattcc 1620 tgagaagaat cgacctttaa aggacagaat taatatagtt ctcagtagag aactcaaaga 1680 accaccacga ggagctcatt ttcttgccaa aagtttggat gatgccttaa gacttattga 1740 acaaccggaa ttggcaagta aagtagacat ggtttggata gtcggaggca gttctgttta 1800 ccaggaagcc atgaatcaac caggccacct cagactcttt gtgacaagga tcatgcagga 1860 atttgaaagt gacacgtttt tcccagaaat tgatttgggg aaatataaac ttctcccaga 1920 gtacccaggt gtgttaagtg aggtgcaaga ggaaaaaggt atcaagtaca agttcgaggt 1980 atatgaaaag aaggattaat ggatccgctc agacatgata agatacattg atgagtttgg 2040 acaaaccaca actagaatgc agtgataatt agactttgag tgatcttgag cctttcctag 2100 ttcatcccac cccgccccag agagatcttt gtgaaggaac cttacttctg tggtgtgaca 2160 taattggaca aactacctac agagatttaa agctctaagg taaatataaa atttttaagt 2220 gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga 2280 actgatgaat gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa 2340 gaaatgccat ctagtgatga tgaggctact gctgactctc aacattctac tcctccacag 2400 acctggtgac cgtcaggaag aagattcagt gagaggacac gaggtatgtc atggttttta 2460 atcaataaat aaagaggttt tattcatcgg acagtcgttg tagcctgtaa aagactcgcc 2520 ccggaggggg ttcccccgat gtgaggggca tgcagtagta tggtgtcctg agtgtctcgg 2580 atgcgtcctt gaactcgcac tctaccgccg tgggggttaa taaagttttg ctgcgccggt 2640 agggggggag gccgaggata ataaagttgc tacgtactgg ttgaagtcta acaatctctc 2700 ggggggatcc gaagacac 2718 <210> 417 <211> 2979 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 417 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggacacaag 240 acaggcttgc gccaccatgg ttgagaatac cactttatcc cgcgtcaggg agaggcagtg 300 cgtaaaaaga cgcggaacca tgtgaaatac tggtttttag tgcgccagat ctctataatc 360 tcgcgcaacc tattttcccc tcgaacactt tttaagccgt agataaacag gctgggacac 420 ttcacatgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac gtccccaggg 480 ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac accgtcgatc 540 cggaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc 600 tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc 660 cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga 720 gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg caccggccca 780 aggagcccgc gtggttcctg gccaccgtcg gcgtgtcgcc cgaccaccag ggcaagggtc 840 tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg gtgcccgcct 900 tcctggagac atccgcgccc cgcaacctcc ccttctacga gcggctcggc ttcaccgtca 960 ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc aagcccggtg 1020 cctgagaaac ccgtatacac cggacctttt ctcccctccc tctccactta cctttttccc 1080 ctcttcggca tgaaacaagg attattcaag tggaaacgcg atttaatatg cggctggcca 1140 ccgcggaata acggcaattg tgtatctgct ggaagccaag cctgcctagc cgatagccct 1200 tgaccgggtg tgtaggatag cccaggaacc agcaatacgc gacaggttat ggtagagtag 1260 atacctagcc aggggcaatg ggactgcatt gcatatccct aatgaaccat tgagatttct 1320 ctggtcatta cccggtgatg gttactagag gggggcctct agtactagat ctatactgcc 1380 tgatagggtc gcggctggcc gaccatgacc tgtatagtca gttgatttga gcaatatggt 1440 tcgaccattg aactgcatcg tcgccgtgtc ccaaaatatg gggattggca agaacggaga 1500 cttgccctgg cctccgctca ggaacgagtt caagtacttc caaagaatga ccacaacctc 1560 ttcagtggaa ggtaaacaga atctggtgat tatgggtagg aaaacctggt tctccattcc 1620 tgagaagaat cgacctttaa aggacagaat taatatagtt ctcagtagag aactcaaaga 1680 accaccacga ggagctcatt ttcttgccaa aagtttggat gatgccttaa gacttattga 1740 acaaccggaa ttggcaagta aagtagacat ggtttggata gtcggaggca gttctgttta 1800 ccaggaagcc atgaatcaac caggccacct cagactcttt gtgacaagga tcatgcagga 1860 atttgaaagt gacacgtttt tcccagaaat tgatttgggg aaatataaac ttctcccaga 1920 gtacccaggt gtgttaagtg aggtgcaaga ggaaaaaggt atcaagtaca agttcgaggt 1980 atatgaaaag aaggattaat ggatccgctc agacatgata agatacattg atgagtttgg 2040 acaaaccaca actagaatgc agtgataatt agactttgag tgatcttgag cctttcctag 2100 ttcatcccac cccgccccag agagatcttt gtgaaggaac cttacttctg tggtgtgaca 2160 taattggaca aactacctac agagatttaa agctctaagg taaatataaa atttttaagt 2220 gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga 2280 actgatgaat gggagcagtg gtggaatgcc tttaatgagg aaaacctgtt ttgctcagaa 2340 gaaatgccat ctagtgatga tgaggctact gctgactctc aacattctac tcctccaaaa 2400 aagaagagaa aggtagaaga tcccaaggac tttccttcag aattgctaag ttttttgagt 2460 catgctgtgt ttagtaatag aactcttgct tgctttgcta tttacaccac aaaggaaaaa 2520 gctgcactgc tatacaagaa aattatggaa aaatattctg taacctttat aagtaggcat 2580 aacagttata atcataacat actgtttttt cttactccac acaggcatag agtgtctgct 2640 attaataact atgctcaaaa attgtgtacc tttagctttt taatttgtaa aggggttaat 2700 aaggaatatt tgatgtatag tgccttgact agagatcata atcagccata ccacatttgt 2760 agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat 2820 gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa 2880 tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc 2940 caaactcatc aatgtatctt atcatgtctg ggaagacac 2979 <210> 418 <211> 2202 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 418 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgaggt 840 taaaaaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg 900 tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg 960 gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg 1020 aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca 1080 aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct 1140 ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca 1200 cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa 1260 ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggta 1320 cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg 1380 gacgtggttt tcctttgaaa aacacgatga taatatggtt cgaccattga actgcatcgt 1440 cgccgtgtcc caaaatatgg ggattggcaa gaacggagac ttgccctggc ctccgctcag 1500 gaacgagttc aagtacttcc aaagaatgac cacaacctct tcagtggaag gtaaacagaa 1560 tctggtgatt atgggtagga aaacctggtt ctccattcct gagaagaatc gacctttaaa 1620 ggacagaatt aatatagttc tcagtagaga actcaaagaa ccaccacgag gagctcattt 1680 tcttgccaaa agtttggatg atgccttaag acttattgaa caaccggaat tggcaagtaa 1740 agtagacatg gtttggatag tcggaggcag ttctgtttac caggaagcca tgaatcaacc 1800 aggccacctc agactctttg tgacaaggat catgcaggaa tttgaaagtg acacgttttt 1860 cccagaaatt gatttgggga aatataaact tctcccagaa tacccaggcg tcctctctga 1920 ggtccaggag gaaaaaggca tcaagtataa gtttgaagtc tacgagaaga aagactaata 1980 gtgactcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc taagtccaac 2040 tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct aataaaaaac 2100 atttattttc attgcaatga tgtatttaaa ttatttctga atattttact aaaaagggaa 2160 tgtgggaggt cagtgcattt aaaacataaa gaaagaagac ac 2202 <210> 419 <211> 2035 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 419 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgagaa 840 acccgtatac accggacctt ttctcccctc cctctccact tacctttttc ccctcttcgg 900 catgaaacaa ggattattca agtggaaacg cgatttaata tgcggctggc caccgcggaa 960 taacggcaat tgtgtatctg ctggaagcca agcctgccta gccgatagcc cttgaccggg 1020 tgtgtaggat agcccaggaa ccagcaatac gcgacaggtt atggtagagt agatacctag 1080 ccaggggcaa tgggactgca ttgcatatcc ctaatgaacc attgagattt ctctggtcat 1140 tacccggtga tggttactag aggggggcct ctagtactag atctatactg cctgataggg 1200 tcgcggctgg ccgaccatga cctgtatagt cagttgattt gagcaatatg gttcgaccat 1260 tgaactgcat cgtcgccgtg tcccaaaata tggggattgg caagaacgga gacttgccct 1320 ggcctccgct caggaacgag ttcaagtact tccaaagaat gaccacaacc tcttcagtgg 1380 aaggtaaaca gaatctggtg attatgggta ggaaaacctg gttctccatt cctgagaaga 1440 atcgaccttt aaaggacaga attaatatag ttctcagtag agaactcaaa gaaccaccac 1500 gaggagctca ttttcttgcc aaaagtttgg atgatgcctt aagacttatt gaacaaccgg 1560 aattggcaag taaagtagac atggtttgga tagtcggagg cagttctgtt taccaggaag 1620 ccatgaatca accaggccac ctcagactct ttgtgacaag gatcatgcag gaatttgaaa 1680 gtgacacgtt tttcccagaa attgatttgg ggaaatataa acttctccca gaatacccag 1740 gcgtcctctc tgaggtccag gaggaaaaag gcatcaagta taagtttgaa gtctacgaga 1800 agaaagacta atagtgactc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt 1860 ccctaagtcc aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg 1920 cctaataaaa aacatttatt ttcattgcaa tgatgtattt aaattatttc tgaatatttt 1980 actaaaaagg gaatgtggga ggtcagtgca tttaaaacat aaagaaagaa gacac 2035 <210> 420 <211> 2366 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 420 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatta 840 aaacagcctg tgggttgtac ccacccacag ggcccactgg gcgctagcac tctggtacta 900 cggtaccttt gtgtgcctgt tttatacccc tccccctact gaaacttaga agcaattcat 960 accgatcaat agtgggcgtg gcacaccagc cgtgtctaga tcaagcactc ctgtttcccc 1020 ggaccgagta tcaatagact gctcacgcgg ttgaaggaga aaacgttcgt tatccggcta 1080 actacttcga aaaacctagt aacaccatga aagttgcgga gtgtttcact cagcacttcc 1140 ccagtgtaga tcaggtcgat gagtcaccgc attcctcacg ggcgaccgtg gcggtggctg 1200 cgctggcggc ctgcctatgg ggtgacccat aggacgctct aatacagaca tggtgcgaag 1260 agtctattga gctagttagt agtcctccgg cccctgaatg cggataatcc taactgtgga 1320 gcagataccc acgaaccagt gggcagtctg tcgtaacggg caactccgca gcggaaccga 1380 ctactttggg tgtccgtgtt tccttttatt ccaaatctgg ctgcttatgg tgacaattga 1440 gagattgttg ccatatagct attggattgg ccatccggtg aataatagag cgataatata 1500 tttgtttgtt ggattcgtgc cacttagtct gaaagttttg agaacactca actacgtttt 1560 attgctgaat agtgcaagat ggttcgacca ttgaactgca tcgtcgccgt gtcccaaaat 1620 atggggattg gcaagaacgg agacttgccc tggcctccgc tcaggaacga gttcaagtac 1680 ttccaaagaa tgaccacaac ctcttcagtg gaaggtaaac agaatctggt gattatgggt 1740 aggaaaacct ggttctccat tcctgagaag aatcgacctt taaaggacag aattaatata 1800 gttctcagta gagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg 1860 gatgatgcct taagacttat tgaacaaccg gaattggcaa gtaaagtaga catggtttgg 1920 atagtcggag gcagttctgt ttaccaggaa gccatgaatc aaccaggcca cctcagactc 1980 tttgtgacaa ggatcatgca ggaatttgaa agtgacacgt ttttcccaga aattgatttg 2040 gggaaatata aacttctccc agaataccca ggcgtcctct ctgaggtcca ggaggaaaaa 2100 ggcatcaagt ataagtttga agtctacgag aagaaagact aatagtgact cgctttcttg 2160 ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat 2220 attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat tttcattgca 2280 atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg aggtcagtgc 2340 atttaaaaca taaagaaaga agacac 2366 <210> 421 <211> 2044 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 421 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgaggg 840 ttttacgaaa cccgtataca ccagaccttt tctcccctcc ccctccacct accttttccc 900 cctctttgga ccgaaacaag gacacgtaag tggaaacgcg attttatatg tggttggcca 960 ccacggaata acggcaattg tctacatgtg ggaagtgcaa cctccctagc cgataacccc 1020 tgaccgggtg tgtaggatag gaaaggtgcc cactgtgggc gacaggttat ggtagagtgg 1080 atacctagcc aggggcaatg ggactgcttt gcatatccct aatgaagtat tgagatttct 1140 ctgctcatta cccggtgatg gttgtgtggg gggggcccca tacactagat ccatactgcc 1200 tgatagggtc gcggctggcc gaccataacc tgtatagtca gttgaattca gccaagatgg 1260 ttcgaccatt gaactgcatc gtcgccgtgt cccaaaatat ggggattggc aagaacggag 1320 acttgccctg gcctccgctc aggaacgagt tcaagtactt ccaaagaatg accacaacct 1380 cttcagtgga aggtaaacag aatctggtga ttatgggtag gaaaacctgg ttctccattc 1440 ctgagaagaa tcgaccttta aaggacagaa ttaatatagt tctcagtaga gaactcaaag 1500 aaccaccacg aggagctcat tttcttgcca aaagtttgga tgatgcctta agacttattg 1560 aacaaccgga attggcaagt aaagtagaca tggtttggat agtcggaggc agttctgttt 1620 accaggaagc catgaatcaa ccaggccacc tcagactctt tgtgacaagg atcatgcagg 1680 aatttgaaag tgacacgttt ttcccagaaa ttgatttggg gaaatataaa cttctcccag 1740 aatacccagg cgtcctctct gaggtccagg aggaaaaagg catcaagtat aagtttgaag 1800 tctacgagaa gaaagactaa tagtgactcg ctttcttgct gtccaatttc tattaaaggt 1860 tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc cttgagcatc 1920 tggattctgc ctaataaaaa acatttattt tcattgcaat gatgtattta aattatttct 1980 gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata aagaaagaag 2040 acac 2044 <210> 422 <211> 2277 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 422 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgagac 840 gaaactacca tcatgcctcc ccgattatgt gatgctttct gccctgctgg gtggagcatc 900 ctcgggttga gaaaaccttc ttcctttttc cttggacccc ggtcccccgg tctaagccgc 960 ttggaataag acagggttat cttcacctct tccttcttct acttcatagt gttctatact 1020 atgaaagggt atgtgtcgcc ccttccttct ttggagaaca cgcgcggcgg tctttccgtc 1080 tctcgaaaag cgcgtgtgcg acatgcagag aaccgtgaag aaagcagttt gcggactagc 1140 tttagtgccc acaagaaaac agctgtagcg accacacaaa ggcagcggac cccccctcct 1200 ggcaacagga gcctctgcgg ccaaaagcca cgtggataag atccaccttt gtgtgcggca 1260 caaccccagt gccctggttt cttggtgaca cttcagtgaa aacgcaaatg gcgatctgaa 1320 gcgcctctgt aggaaagcca agaatgtcca ggaggtaccc cttccctcgg gaagggatct 1380 gacctggaga cacatcacat gtgctttaca cctgtgcttg tgtttaaaaa ttgtcacagc 1440 tttcccaaac caagtggtct tggttttcac tctttaaact gatttcacta tggttcgacc 1500 attgaactgc atcgtcgccg tgtcccaaaa tatggggatt ggcaagaacg gagacttgcc 1560 ctggcctccg ctcaggaacg agttcaagta cttccaaaga atgaccacaa cctcttcagt 1620 ggaaggtaaa cagaatctgg tgattatggg taggaaaacc tggttctcca ttcctgagaa 1680 gaatcgacct ttaaaggaca gaattaatat agttctcagt agagaactca aagaaccacc 1740 acgaggagct cattttcttg ccaaaagttt ggatgatgcc ttaagactta ttgaacaacc 1800 ggaattggca agtaaagtag acatggtttg gatagtcgga ggcagttctg tttaccagga 1860 agccatgaat caaccaggcc acctcagact ctttgtgaca aggatcatgc aggaatttga 1920 aagtgacacg tttttcccag aaattgattt ggggaaatat aaacttctcc cagaataccc 1980 aggcgtcctc tctgaggtcc aggaggaaaa aggcatcaag tataagtttg aagtctacga 2040 gaagaaagac taatagtgac tcgctttctt gctgtccaat ttctattaaa ggttcctttg 2100 ttccctaagt ccaactacta aactggggga tattatgaag ggccttgagc atctggattc 2160 tgcctaataa aaaacattta ttttcattgc aatgatgtat ttaaattatt tctgaatatt 2220 ttactaaaaa gggaatgtgg gaggtcagtg catttaaaac ataaagaaag aagacac 2277 <210> 423 <211> 2291 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 423 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgagtt 840 ttacaccccc ttaccctaat agcaacttag aaggctcaat gcatctacga ccaatagcag 900 gcgcgacggc accaagtcgt gtctcggtca agcacttctg tttccccggg accgagtatc 960 aatagactgc tcacgcggtt gaaggagaaa gcgttcgtta cccggccatc tacttcgaga 1020 agcctagtaa caccatgaaa gttgcagagc gtttcgctca gcacttcccc cgtgtagatc 1080 aggccgatga gtcactgcaa ccctcacggg cgaccgtggc agtggctgcg ttggcggcct 1140 gcccatggga ttacccatgg gacgctctaa tacagacatg gtgtgaagaa cctattgagc 1200 tagttggtag tcctccggcc cctgaatgcg gctaatccta actgcggagc atacaccctc 1260 aatccagggg gcagtgtgtc gtaacgggca actctgcagc ggaaccgact actttgggtg 1320 tccgtgtttc cttttattct tattatggct gcttatggtg acaattgaga gattgttgcc 1380 atatagctat tggattggcc atccggtgag caatagagcg attatttact cttttgttgg 1440 atttgtgcca ttggatcaca ccacaatcat cacactaaag tatattttac tattaaatac 1500 agcaaaatgg ttcgaccatt gaactgcatc gtcgccgtgt cccaaaatat ggggattggc 1560 aagaacggag acttgccctg gcctccgctc aggaacgagt tcaagtactt ccaaagaatg 1620 accacaacct cttcagtgga aggtaaacag aatctggtga ttatgggtag gaaaacctgg 1680 ttctccattc ctgagaagaa tcgaccttta aaggacagaa ttaatatagt tctcagtaga 1740 gaactcaaag aaccaccacg aggagctcat tttcttgcca aaagtttgga tgatgcctta 1800 agacttattg aacaaccgga attggcaagt aaagtagaca tggtttggat agtcggaggc 1860 agttctgttt accaggaagc catgaatcaa ccaggccacc tcagactctt tgtgacaagg 1920 atcatgcagg aatttgaaag tgacacgttt ttcccagaaa ttgatttggg gaaatataaa 1980 cttctcccag agtacccagg tgtgttaagt gaggtgcaag aggaaaaagg tatcaagtac 2040 aagttcgagg tatatgaaaa gaaggattaa tgactcgctt tcttgctgtc caatttctat 2100 taaaggttcc tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt 2160 gagcatctgg attctgccta ataaaaaaca tttattttca ttgcaatgat gtatttaaat 2220 tatttctgaa tattttacta aaaagggaat gtgggaggtc agtgcattta aaacataaag 2280 aaagaagaca c 2291 <210> 424 <211> 2366 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 424 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatta 840 aaacagcctg tgggttgtac ccacccacag ggcccactgg gcgctagcac tctggtacta 900 cggtaccttt gtgtgcctgt tttatacccc tccccctact gaaacttaga agcaattcat 960 accgatcaat agtgggcgtg gcacaccagc cgtgtctaga tcaagcactc ctgtttcccc 1020 ggaccgagta tcaatagact gctcacgcgg ttgaaggaga aaacgttcgt tatccggcta 1080 actacttcga aaaacctagt aacaccatga aagttgcgga gtgtttcact cagcacttcc 1140 ccagtgtaga tcaggtcgat gagtcaccgc attcctcacg ggcgaccgtg gcggtggctg 1200 cgctggcggc ctgcctatgg ggtgacccat aggacgctct aatacagaca tggtgcgaag 1260 agtctattga gctagttagt agtcctccgg cccctgaatg cggataatcc taactgtgga 1320 gcagataccc acgaaccagt gggcagtctg tcgtaacggg caactccgca gcggaaccga 1380 ctactttggg tgtccgtgtt tccttttatt ccaaatctgg ctgcttatgg tgacaattga 1440 gagattgttg ccatatagct attggattgg ccatccggtg aataatagag cgataatata 1500 tttgtttgtt ggattcgtgc cacttagtct gaaagaggtt aaaacattac aattcattgt 1560 taagttgaat acagcaaaat ggttcgacca ttgaactgca tcgtcgccgt gtcccaaaat 1620 atggggattg gcaagaacgg agacttgccc tggcctccgc tcaggaacga gttcaagtac 1680 ttccaaagaa tgaccacaac ctcttcagtg gaaggtaaac agaatctggt gattatgggt 1740 aggaaaacct ggttctccat tcctgagaag aatcgacctt taaaggacag aattaatata 1800 gttctcagta gagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg 1860 gatgatgcct taagacttat tgaacaaccg gaattggcaa gtaaagtaga catggtttgg 1920 atagtcggag gcagttctgt ttaccaggaa gccatgaatc aaccaggcca cctcagactc 1980 tttgtgacaa ggatcatgca ggaatttgaa agtgacacgt ttttcccaga aattgatttg 2040 gggaaatata aacttctccc agaataccca ggcgtcctct ctgaggtcca ggaggaaaaa 2100 ggcatcaagt ataagtttga agtctacgag aagaaagact aatagtgact cgctttcttg 2160 ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat 2220 attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat tttcattgca 2280 atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg aggtcagtgc 2340 atttaaaaca taaagaaaga agacac 2366 <210> 425 <211> 2308 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 425 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgatta 840 aaacagcctg tgggttgtac ccacccacag ggcccactgg gcgctagcac tctggtacta 900 cggtaccttt gtgtgcctgt tttatacccc tccccctact gaaacttaga agcaattcat 960 accgatcaat agtgggcgtg gcacaccagc cgtgtctaga tcaagcactc ctgtttcccc 1020 ggaccgagta tcaatagact gctcacgcgg ttgaaggaga aaacgttcgt tatccggcta 1080 actacttcga aaaacctagt aacaccatga aagttgcgga gtgtttcact cagcacttcc 1140 ccagtgtaga tcaggtcgat gagtcaccgc attcctcacg ggcgaccgtg gcggtggctg 1200 cgctggcggc ctgcctatgg ggtgacccat aggacgctct aatacagaca tggtgcgaag 1260 agtctattga gctagttagt agtcctccgg cccctgaatg cggataatcc taactgtgga 1320 gcagataccc acgaaccagt gggcagtctg tcgtaacggg caactccgca gcggaaccga 1380 ctactttggg tgtccgtgtt tccttttatt ccaaatctgg ctgcttatgg tgacaattga 1440 gagattgttg ccatatagct attggattgg ccatccggtg aataatagag cgataatata 1500 tttgtttgtt ggattcgtgc cacatggttc gaccattgaa ctgcatcgtc gccgtgtccc 1560 aaaatatggg gattggcaag aacggagact tgccctggcc tccgctcagg aacgagttca 1620 agtacttcca aagaatgacc acaacctctt cagtggaagg taaacagaat ctggtgatta 1680 tgggtaggaa aacctggttc tccattcctg agaagaatcg acctttaaag gacagaatta 1740 atatagttct cagtagagaa ctcaaagaac caccacgagg agctcatttt cttgccaaaa 1800 gtttggatga tgccttaaga cttattgaac aaccggaatt ggcaagtaaa gtagacatgg 1860 tttggatagt cggaggcagt tctgtttacc aggaagccat gaatcaacca ggccacctca 1920 gactctttgt gacaaggatc atgcaggaat ttgaaagtga cacgtttttc ccagaaattg 1980 atttggggaa atataaactt ctcccagagt acccaggtgt gttaagtgag gtgcaagagg 2040 aaaaaggtat caagtacaag ttcgaggtat atgaaaagaa ggattaatga ctcgctttct 2100 tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact aaactggggg 2160 atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt attttcattg 2220 caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg ggaggtcagt 2280 gcatttaaaa cataaagaaa gaagacac 2308 <210> 426 <211> 1920 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 426 aagtcttctt aattaattgg cgaaaacacg cagatgcagt cggggcggcg cggtcccagg 60 tccacttcgc atattaaggt gacgcgtgtg gcctcgaaca cagagcgact ctgcagggtg 120 gcatgaccga gtacaagccc acggtgcgcc tcgccacccg cgacgacgtc cccagggccg 180 tacgcaccct cgccgccgcg ttcgccgact accccgccac gcgccacacc gtcgatccgg 240 accgccacat cgagcgggtc accgagctgc aagaactctt cctcacgcgc gtcgggctcg 300 acatcggcaa ggtgtgggtc gcggacgacg gcgccgcggt ggcggtctgg accacgccgg 360 agagcgtcga agcgggggcg gtgttcgccg agatcggccc gcgcatggcc gagttgagcg 420 gttcccggct ggccgcgcag caacagatgg aaggcctcct ggcgccgcac cggcccaagg 480 agcccgcgtg gttcctggcc accgtcggcg tgtcgcccga ccaccagggc aagggtctgg 540 gcagcgccgt cgtgctcccc ggagtggagg cggccgagcg cgccggggtg cccgccttcc 600 tggagacatc cgcgccccgc aacctcccct tctacgagcg gctcggcttc accgtcaccg 660 ccgacgtcga ggtgcccgaa ggaccgcgca cctggtgcat gacccgcaag cccggtgcct 720 gagaaacccg tatacaccgg accttttctc ccctccctct ccacttacct ttttcccctc 780 ttcggcatga aacaaggatt attcaagtgg aaacgcgatt taatatgcgg ctggccaccg 840 cggaataacg gcaattgtgt atctgctgga agccaagcct gcctagccga tagcccttga 900 ccgggtgtgt aggatagccc aggaaccagc aatacgcgac aggttatggt agagtagata 960 cctagccagg ggcaatggga ctgcattgca tatccctaat gaaccattga gatttctctg 1020 gtcattaccc ggtgatggtt actagagggg ggcctctagt actagatcta tactgcctga 1080 tagggtcgcg gctggccgac catgacctgt atagtcagtt gatttgagca atatggttcg 1140 accattgaac tgcatcgtcg ccgtgtccca aaatatgggg attggcaaga acggagactt 1200 gccctggcct ccgctcagga acgagttcaa gtacttccaa agaatgacca caacctcttc 1260 agtggaaggt aaacagaatc tggtgattat gggtaggaaa acctggttct ccattcctga 1320 gaagaatcga cctttaaagg acagaattaa tatagttctc agtagagaac tcaaagaacc 1380 accacgagga gctcattttc ttgccaaaag tttggatgat gccttaagac ttattgaaca 1440 accggaattg gcaagtaaag tagacatggt ttggatagtc ggaggcagtt ctgtttacca 1500 ggaagccatg aatcaaccag gccacctcag actctttgtg acaaggatca tgcaggaatt 1560 tgaaagtgac acgtttttcc cagaaattga tttggggaaa tataaacttc tcccagaata 1620 cccaggcgtc ctctctgagg tccaggagga aaaaggcatc aagtataagt ttgaagtcta 1680 cgagaagaaa gactaatagt gactcgcttt cttgctgtcc aatttctatt aaaggttcct 1740 ttgttcccta agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga 1800 ttctgcctaa taaaaaacat ttattttcat tgcaatgatg tatttaaatt atttctgaat 1860 attttactaa aaagggaatg tgggaggtca gtgcatttaa aacataaaga aagaagacac 1920 <210> 427 <211> 1709 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 427 aagtcttctt aattaacagc tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg 60 tgtccccgga agaaatatat ttgcatgtct ttagttctat gatgacacaa accccgccca 120 gcgtcttgtc attggcgaaa acacgcagat gcagtcgggg cggcgcggtc ccaggtccac 180 ttcgcatatt aaggtgacgc gtgtggcctc gaacacagag cgactctgca gggtggcatg 240 accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtccccag ggccgtacgc 300 accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga tccggaccgc 360 cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc 420 ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc 480 gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc 540 cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc 600 gcgtggttcc tggccaccgt cggcgtgtcg cccgaccacc agggcaaggg tctgggcagc 660 gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag 720 acatccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac 780 gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgccggtaca 840 tctgagggca ggggaagtct gctaacatgc ggggacgtgg aggaaaatcc cggccccatg 900 gttcgaccat tgaactgcat cgtcgccgtg tcccaaaata tggggattgg caagaacgga 960 gatcttccct ggcctccgct caggaacgag ttcaagtact tccaaagaat gaccacaacc 1020 tcttcagtgg aaggtaaaca gaatctggtg attatgggta ggaaaacctg gttctccatt 1080 cctgagaaga atcgaccttt aaaggacaga attaatatag ttctcagtag agaactcaaa 1140 gaaccaccac gaggagctca ttttcttgcc aaaagtttgg atgatgcctt aagacttatt 1200 gaacaaccgg aattggcaag taaagtagac atggtttgga tagtcggagg cagttctgtt 1260 taccaggaag ccatgaatca accaggccac ctcagactct ttgtgacaag gatcatgcag 1320 gaatttgaaa gtgacacgtt tttcccagaa attgatttgg ggaaatataa acttctccca 1380 gaatacccag gcgtcctctc tgaggtccag gaggaaaaag gcatcaagta taagtttgaa 1440 gtctacgaga agaaagacta atggatccgc tcagacatga taagatacat tgatgagttt 1500 ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct 1560 attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt 1620 cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc 1680 tacaaatgtg gtaggcgcgc cgaagacaa 1709 <210> 428 <211> 1731 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 428 taaatgcact gacctcccac attccctttt tagtaaaata ttcagaaata atttaaatac 60 atcattgcaa tgaaaataaa tgttttttat taggcagaat ccagatgctc aaggcccttc 120 ataatatccc ccagtttagt agttggactt agggaacaaa ggaaccttta atagaaattg 180 gacagcaaga aagcgagtta tcattagtct ttcttctcgt agacttcaaa cttatacttg 240 atgccttttt cctcctggac ctcagagagg acgcctgggt attctgggag aagtttatat 300 ttccccaaat caatttctgg gaaaaacgtg tcactttcaa attcctgcat gatccttgtc 360 acaaagagtc tgaggtggcc tggttgattc atggcttcct ggtaaacaga actgcctccg 420 actatccaaa ccatgtctac tttacttgcc aattccggtt gttcaataag tcttaaggca 480 tcatccaaac ttttggcaag aaaatgagct cctcgtggtg gttctttgag ttctctactg 540 agaactatat taattctgtc ctttaaaggt cgattcttct caggaatgga gaaccaggtt 600 ttcctaccca taatcaccag attctgttta ccttccactg aagaggttgt ggtcattctt 660 tggaagtact tgaactcgtt cctgagcgga ggccagggca agtctccgtt cttgccaatc 720 cccatatttt gggacacggc gacgatgcag ttcaatggtc gaaccatggg gccgggattt 780 tcctccacgt ccccgcatgt tagcagactt cccctgccct cagatgtacc ggcaccgggc 840 ttgcgggtca tgcaccaggt gcgcggtcct tcgggcacct cgacgtcggc ggtgacggtg 900 aagccgagcc gctcgtagaa ggggaggttg cggggcgcgg atgtctccag gaaggcgggc 960 accccggcgc gctcggccgc ctccactccg gggagcacga cggcgctgcc cagacccttg 1020 ccctggtggt cgggcgacac gccgacggtg gccaggaacc acgcgggctc cttgggccgg 1080 tgcggcgcca ggaggccttc catctgttgc tgcgcggcca gccgggaacc gctcaactcg 1140 gccatgcgcg ggccgatctc ggcgaacacc gcccccgctt cgacgctctc cggcgtggtc 1200 cagaccgcca ccgcggcgcc gtcgtccgcg acccacacct tgccgatgtc gagcccgacg 1260 cgcgtgagga agagttcttg cagctcggtg acccgctcga tgtggcggtc cggatcgacg 1320 gtgtggcgcg tggcggggta gtcggcgaac gcggcggcga gggtgcgtac ggccctgggg 1380 acgtcgtcgc gggtggcgag gcgcaccgtg ggcttgtact cggtcatggt ggcggctcta 1440 gacagcttgg gtgtacctgc gaagcccctg agacggacgt gcgctccgga ggcttgcaga 1500 atgcggaaca ccgcgcgggc aggaacaggg cccacactac cgccccacac cccgcctccc 1560 gcaccgcccc ttcccggccg ctgctctcag aaagcgaagg agcaaagctg ctattggccg 1620 ctgccccaaa ggcctacccg cttccattgc tcagcggtgc tgtccatctg cacgagacta 1680 gtgagtcgtg ctacttccat ttgtcacgtc ctgcacgacg cgagctgcgg g 1731 <210> 429 <211> 2001 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 429 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag ttatcattag tctttcttct 240 cgtagacttc aaacttatac ttgatgcctt tttcctcctg gacctcagag aggacgcctg 300 ggtattctgg gagaagttta tatttcccca aatcaatttc tgggaaaaac gtgtcacttt 360 caaattcctg catgatcctt gtcacaaaga gtctgaggtg gcctggttga ttcatggctt 420 cctggtaaac agaactgcct ccgactatcc aaaccatgtc tactttactt gccaattccg 480 gttgttcaat aagtcttaag gcatcatcca aacttttggc aagaaaatga gctcctcgtg 540 gtggttcttt gagttctcta ctgagaacta tattaattct gtcctttaaa ggtcgattct 600 tctcaggaat ggagaaccag gttttcctac ccataatcac cagattctgt ttaccttcca 660 ctgaagaggt tgtggtcatt ctttggaagt acttgaactc gttcctgagc ggaggccagg 720 gcaagtctcc gttcttgcca atccccatat tttgggacac ggcgacgatg cagttcaatg 780 gtcgaaccat ggggccggga ttttcctcca cgtccccgca tgttagcaga cttcccctgc 840 cctcagatgt accggcaccg ggcttgcggg tcatgcacca ggtgcgcggt ccttcgggca 900 cctcgacgtc ggcggtgacg gtgaagccga gccgctcgta gaaggggagg ttgcggggcg 960 cggatgtctc caggaaggcg ggcaccccgg cgcgctcggc cgcctccact ccggggagca 1020 cgacggcgct gcccagaccc ttgccctggt ggtcgggcga cacgccgacg gtggccagga 1080 accacgcggg ctccttgggc cggtgcggcg ccaggaggcc ttccatctgt tgctgcgcgg 1140 ccagccggga accgctcaac tcggccatgc gcgggccgat ctcggcgaac accgcccccg 1200 cttcgacgct ctccggcgtg gtccagaccg ccaccgcggc gccgtcgtcc gcgacccaca 1260 ccttgccgat gtcgagcccg acgcgcgtga ggaagagttc ttgcagctcg gtgacccgct 1320 cgatgtggcg gtccggatcg acggtgtggc gcgtggcggg gtagtcggcg aacgcggcgg 1380 cgagggtgcg tacggccctg gggacgtcgt cgcgggtggc gaggcgcacc gtgggcttgt 1440 actcggtcat ggtggcggct ctagacagct tgggtgtgac gtgcgctccg gaggcttgca 1500 gaatgcggaa caccgcgcgg gcaggaacag ggcccacact accgccccac accccgcctc 1560 ccgcaccgcc ccttcccggc cgctgctctc agaaagcgaa ggagcaaagc tgctattggc 1620 cgctgcccca aaggcctacc cgcttccatt gctcagcggt gctgtccatc tgcacgagac 1680 tagtgagtcg tgctacttcc atttgtcacg tcctgcacga cgcgagctgc ggggcggggg 1740 ggaacttcct gactagggga ggagtagaag gtggcgcgaa ggggccacca aagaacggag 1800 ccggttggcg cctaccggtg gatgtggaat gtgtgcgagg ccagaggcca cttgtgtagc 1860 gccaagtgcc cagcggggct gctaaagcgc atgctccaga ctgccttggg aaaagcgcct 1920 cccctacccg gtagagaaac ttgatctgtc gccgcaattc aaacttcgtg aggctccggt 1980 gcccgtcagt gacctgctat a 2001 <210> 430 <211> 2022 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 430 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag ttatcattag tctttcttct 240 cgtagacttc aaacttatac ttgatgcctt tttcctcctg gacctcagag aggacgcctg 300 ggtattctgg gagaagttta tatttcccca aatcaatttc tgggaaaaac gtgtcacttt 360 caaattcctg catgatcctt gtcacaaaga gtctgaggtg gcctggttga ttcatggctt 420 cctggtaaac agaactgcct ccgactatcc aaaccatgtc tactttactt gccaattccg 480 gttgttcaat aagtcttaag gcatcatcca aacttttggc aagaaaatga gctcctcgtg 540 gtggttcttt gagttctcta ctgagaacta tattaattct gtcctttaaa ggtcgattct 600 tctcaggaat ggagaaccag gttttcctac ccataatcac cagattctgt ttaccttcca 660 ctgaagaggt tgtggtcatt ctttggaagt acttgaactc gttcctgagc ggaggccagg 720 gcaagtctcc gttcttgcca atccccatat tttgggacac ggcgacgatg cagttcaatg 780 gtcgaaccat ggggccggga ttttcctcca cgtccccgca tgttagcaga cttcccctgc 840 cctcagatgt accggcaccg ggcttgcggg tcatgcacca ggtgcgcggt ccttcgggca 900 cctcgacgtc ggcggtgacg gtgaagccga gccgctcgta gaaggggagg ttgcggggcg 960 cggatgtctc caggaaggcg ggcaccccgg cgcgctcggc cgcctccact ccggggagca 1020 cgacggcgct gcccagaccc ttgccctggt ggtcgggcga cacgccgacg gtggccagga 1080 accacgcggg ctccttgggc cggtgcggcg ccaggaggcc ttccatctgt tgctgcgcgg 1140 ccagccggga accgctcaac tcggccatgc gcgggccgat ctcggcgaac accgcccccg 1200 cttcgacgct ctccggcgtg gtccagaccg ccaccgcggc gccgtcgtcc gcgacccaca 1260 ccttgccgat gtcgagcccg acgcgcgtga ggaagagttc ttgcagctcg gtgacccgct 1320 cgatgtggcg gtccggatcg acggtgtggc gcgtggcggg gtagtcggcg aacgcggcgg 1380 cgagggtgcg tacggccctg gggacgtcgt cgcgggtggc gaggcgcacc gtgggcttgt 1440 actcggtcat ggtggcggct ctagacagct tgggtgtacc tgcgaagccc ctgagacgga 1500 cgtgcgctcc ggaggcttgc agaatgcgga acaccgcgcg ggcaggaaca gggcccacac 1560 taccgcccca caccccgcct cccgcaccgc cccttcccgg ccgctgctct cagaaagcga 1620 aggagcaaag ctgctattgg ccgctgcccc aaaggcctac ccgcttccat tgctcagcgg 1680 tgctgtccat ctgcacgaga ctagtgagtc gtgctacttc catttgtcac gtcctgcacg 1740 acgcgagctg cggggcgggg gggaacttcc tgactagggg aggagtagaa ggtggcgcga 1800 aggggccacc aaagaacgga gccggttggc gcctaccggt ggatgtggaa tgtgtgcgag 1860 gccagaggcc acttgtgtag cgccaagtgc ccagcggggc tgctaaagcg catgctccag 1920 actgccttgg gaaaagcgcc tcccctaccc ggtagagaaa cttgatctgt cgccgcaatt 1980 caaacttcgt gaggctccgg tgcccgtcag tgacctgcta ta 2022 <210> 431 <211> 1926 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 431 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag tcactatcag cccttctgcc 240 aaatctggta gctatagttg atgttcgagg cgaagtcttg ggtgaacacc ggcctaaagt 300 tgctcgggat ctcagggaag tacacatctc cttcgggttc gatgtcgatg gtggagatgt 360 gcagagtgtc cacttggtcg atcagtgact tgtagatttc gccccctccg gacacaatga 420 catggtcggt gatcttcttg aggttcgtga gagcgtcctt gatcgaaggg aagatcagca 480 catcctcatt gtcggaagtg aagctggatc tggtcacgac ggcgtatttc cggttcggca 540 gggcacccat ggattcgaaa gtcttgcgac cgacaagcaa ccactggttg taggtgatgg 600 ccttgaacag cagctgctct ccctttgcgg accagggaat atctgggccg ttcccaatca 660 ctccgttctt tgaaatcgcc accatggggc cgggattttc ctccacgtcc ccgcatgtta 720 gcagacttcc cctgccctca gatgtaccgg caccgggctt gcgggtcatg caccaggtgc 780 gcggtccttc gggcacctcg acgtcggcgg tgacggtgaa gccgagccgc tcgtagaagg 840 ggaggttgcg gggcgcggat gtctccagga aggcgggcac cccggcgcgc tcggccgcct 900 ccactccggg gagcacgacg gcgctgccca gacccttgcc ctggtggtcg ggcgacacgc 960 cgacggtggc caggaaccac gcgggctcct tgggccggtg cggcgccagg aggccttcca 1020 tctgttgctg cgcggccagc cgggaaccgc tcaactcggc catgcgcggg ccgatctcgg 1080 cgaacaccgc ccccgcttcg acgctctccg gcgtggtcca gaccgccacc gcggcgccgt 1140 cgtccgcgac ccacaccttg ccgatgtcga gcccgacgcg cgtgaggaag agttcttgca 1200 gctcggtgac ccgctcgatg tggcggtccg gatcgacggt gtggcgcgtg gcggggtagt 1260 cggcgaacgc ggcggcgagg gtgcgtacgg ccctggggac gtcgtcgcgg gtggcgaggc 1320 gcaccgtggg cttgtactcg gtcatggtgg cggacgaaag gcccggagat gaggaagagg 1380 agaacagcgc ggcagacgtg cgcttttgaa gcgtgcagaa tgccgggcct ccggaggacc 1440 ttcgggcgcc cgccccgccc ctgagcccgc ccctgagccc gcccccggac ccaccccttc 1500 ccagcctctg agcccagaaa gcgaaggagc aaagctgcta ttggccgctg ccccaaaggc 1560 ctacccgctt ccattgctca gcggtgctgt ccatctgcac gagactagtg agtcgtgcta 1620 cttccatttg tcacgtcctg cacgacgcga gctgcggggc gggggggaac ttcctgacta 1680 ggggaggagt agaaggtggc gcgaaggggc caccaaagaa cggagccggt tggcgcctac 1740 cggtggatgt ggaatgtgtg cgaggccaga ggccacttgt gtagcgccaa gtgcccagcg 1800 gggctgctaa agcgcatgct ccagactgcc ttgggaaaag cgcctcccct acccggtaga 1860 gaaacttgat ctgtcgccgc aattcaaact tcgtgaggct ccggtgcccg tcagtgacct 1920 gctata 1926 <210> 432 <211> 2921 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 432 tagtcttcca ctgacgggca ccggagcctc acgaagtttg aattgcggcg acagatcaag 60 tttctctacc gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca 120 gccccgctgg gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc 180 accggtaggc gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct 240 cccctagtca ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg 300 gaagtagcac gactcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg 360 gtaggccttt ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagggg 420 cggggcgggc gcccgaaggt cctccggagg cccggcattc tgcacgcttc aaaagcgcac 480 gtctgccgcg ctgttctcct cttcctcatc tccgggcctt tcgtcacacc caagctgtct 540 agagccgcca ccatgaccga gtacaagccc acggtgcgcc tcgccacccg cgacgacgtc 600 cccagggccg tacgcaccct cgccgccgcg ttcgccgact accccgccac gcgccacacc 660 gtcgatccgg accgccacat cgagcgggtc accgagctgc aagaactctt cctcacgcgc 720 gtcgggctcg acatcggcaa ggtgtgggtc gcggacgacg gcgccgcggt ggcggtctgg 780 accacgccgg agagcgtcga agcgggggcg gtgttcgccg agatcggccc gcgcatggcc 840 gagttgagcg gttcccggct ggccgcgcag caacagatgg aaggcctcct ggcgccgcac 900 cggcccaagg agcccgcgtg gttcctggcc accgtcggcg tgtcgcccga ccaccagggc 960 aagggtctgg gcagcgccgt cgtgctcccc ggagtggagg cggccgagcg cgccggggtg 1020 cccgccttcc tggagacatc cgcgccccgc aacctcccct tctacgagcg gctcggcttc 1080 accgtcaccg ccgacgtcga ggtgcccgaa ggaccgcgca cctggtgcat gacccgcaag 1140 cccggtgcct gagaaacccg tatacaccgg accttttctc ccctccctct ccacttacct 1200 ttttcccctc ttcggcatga aacaaggatt attcaagtgg aaacgcgatt taatatgcgg 1260 ctggccaccg cggaataacg gcaattgtgt atctgctgga agccaagcct gcctagccga 1320 tagcccttga ccgggtgtgt aggatagccc aggaaccagc aatacgcgac aggttatggt 1380 agagtagata cctagccagg ggcaatggga ctgcattgca tatccctaat gaaccattga 1440 gatttctctg gtcattaccc ggtgatggtt actagagggg ggcctctagt actagatcta 1500 tactgcctga tagggtcgcg gctggccgac catgacctgt atagtcagtt gatttgagca 1560 atatggccac ctcagcaagt tcccacttga acaaaaacat caagcaaatg tacttgtgcc 1620 tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtact ggagaaggac 1680 tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag ttacctgagt 1740 ggaattttga tggctctagt acctttcagt ctgagggctc caacagtgac atgtatctca 1800 gccctgttgc catgtttcgg gaccccttcc gcagagatcc caacaagctg gtgttctgtg 1860 aagttttcaa gtacaaccgg aagcctgcag agacaaattt aaggcactcg tgtaaacgga 1920 taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag tatactctga 1980 tgggaacaga tgggcaccct tttggttggc cttccaatgg ctttcctggg ccccaaggtc 2040 cgtattactg tggtgtgggc gcagacaaag cctatggcag ggatatcgtg gaggctcact 2100 accgcgcctg cttgtatgct ggggtcaaga ttacaggaac aaatgctgag gtcatgcctg 2160 cccagtggga gttccaaata ggaccctgtg aaggaatccg catgggagat catctctggg 2220 tggcccgttt catcttgcat cgagtatgtg aggactttgg ggtaatagca acctttgacc 2280 ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt agcaccaagg 2340 ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc catcgagaaa ctaagcaagc 2400 ggcaccggta ccacattcga gcctacgatc ccaagggggg cctggacaat gcccgtcgtc 2460 tgactgggtt ccacgaaacg tccaacatca acgacttttc tgctggtgtc gccaatcgca 2520 gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac tttgaagatc 2580 gccgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc cgcacatgcc 2640 ttctcaatga gactggcgac gagcccttcc aatacaaaaa ctggatccgc tcagacatga 2700 taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta 2760 tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag 2820 ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt 2880 tttaaagcaa gtaaaacctc tacaaatgtg gtagaagaca g 2921 <210> 433 <211> 2577 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 433 gtaagcaggt tttctttatg ttttaaatgc actgacctcc cacattccct ttttagtaaa 60 atattcagaa ataatttaaa tacatcattg caatgaaaat aaatgttttt tattaggcag 120 aatccagatg ctcaaggccc ttcataatat cccccagttt agtagttgga cttagggaac 180 aaaggaacct ttaatagaaa ttggacagca agaaagcgag ttatcagttt ttgtattgga 240 agggctcgtc gccagtctca ttgagaaggc atgtgcggac gatggcttct gtcactgcaa 300 aggggtcaca attggcagag gggcggcgat cttcaaagta acctttcttc tcctggccga 360 cagtccgggg aatgcggatg ctggcactgc gattggcgac accagcagaa aagtcgttga 420 tgttggacgt ttcgtggaac ccagtcagac gacgggcatt gtccaggccc cccttgggat 480 cgtaggctcg aatgtggtac cggtgccgct tgcttagttt ctcgatggcc tcctcgatgt 540 gcttcagacc attctcctcc cgcatggcct tggtgctaaa gttggtatgg cagcctgcac 600 cattccagtt cccaggaatg ggcttggggt caaaggttgc tattacccca aagtcctcac 660 atactcgatg caagatgaaa cgggccaccc agagatgatc tcccatgcgg attccttcac 720 agggtcctat ttggaactcc cactgggcag gcatgacctc agcatttgtt cctgtaatct 780 tgaccccagc atacaagcag gcgcggtagt gagcctccac gatatccctg ccataggctt 840 tgtctgcgcc cacaccacag taatacggac cttggggccc aggaaagcca ttggaaggcc 900 aaccaaaagg gtgcccatct gttcccatca gagtatactc ctgttccatt ccaaaccagg 960 ggtgctggtt gctcaccatg tccattatcc gtttacacga gtgccttaaa tttgtctctg 1020 caggcttccg gttgtacttg aaaacttcac agaacaccag cttgttggga tctctgcgga 1080 aggggtcccg aaacatggca acagggctga gatacatgtc actgttggag ccctcagact 1140 gaaaggtact agagccatca aaattccact caggtaactc ttctacacac ttgggctcac 1200 agtccagggt gcgggttttg cagcgcagtc cttctccagt accatcaacc cagatataca 1260 tggcttggac tttctcaccc tggggcaggc acaagtacat ttgcttgatg tttttgttca 1320 agtgggaact tgctgaggtg gccatggggc cgggattttc ctccacgtcc ccgcatgtta 1380 gcagacttcc cctgccctca gatgtaccgg caccgggctt gcgggtcatg caccaggtgc 1440 gcggtccttc gggcacctcg acgtcggcgg tgacggtgaa gccgagccgc tcgtagaagg 1500 ggaggttgcg gggcgcggat gtctccagga aggcgggcac cccggcgcgc tcggccgcct 1560 ccactccggg gagcacgacg gcgctgccca gacccttgcc ctggtggtcg ggcgacacgc 1620 cgacggtggc caggaaccac gcgggctcct tgggccggtg cggcgccagg aggccttcca 1680 tctgttgctg cgcggccagc cgggaaccgc tcaactcggc catgcgcggg ccgatctcgg 1740 cgaacaccgc ccccgcttcg acgctctccg gcgtggtcca gaccgccacc gcggcgccgt 1800 cgtccgcgac ccacaccttg ccgatgtcga gcccgacgcg cgtgaggaag agttcttgca 1860 gctcggtgac ccgctcgatg tggcggtccg gatcgacggt gtggcgcgtg gcggggtagt 1920 cggcgaacgc ggcggcgagg gtgcgtacgg ccctggggac gtcgtcgcgg gtggcgaggc 1980 gcaccgtggg cttgtactcg gtcatggtgg cggctctaga cagcttgggt gtacctgcga 2040 agcccctgag acggacgtgc gctccggagg cttgcagaat gcggaacacc gcgcgggcag 2100 gaacagggcc cacactaccg ccccacaccc cgcctcccgc accgcccctt cccggccgct 2160 gctctcagaa agcgaaggag caaagctgct attggccgct gccccaaagg cctacccgct 2220 tccattgctc agcggtgctg tccatctgca cgagactagt gagtcgtgct acttccattt 2280 gtcacgtcct gcacgacgcg agctgcgggg cgggggggaa cttcctgact aggggaggag 2340 tagaaggtgg cgcgaagggg ccaccaaaga acggagccgg ttggcgccta ccggtggatg 2400 tggaatgtgt gcgaggccag aggccacttg tgtagcgcca agtgcccagc ggggctgcta 2460 aagcgcatgc tccagactgc cttgggaaaa gcgcctcccc tacccggtag agaaacttga 2520 tctgtcgccg caattcaaac ttcgtgaggc tccggtgccc gtcagtgacc tgctata 2577 <210> 434 <211> 2286 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 434 taaatgcact gacctcccac attccctttt tagtaaaata ttcagaaata atttaaatac 60 atcattgcaa tgaaaataaa tgttttttat taggcagaat ccagatgctc aaggcccttc 120 ataatatccc ccagtttagt agttggactt agggaacaaa ggaaccttta atagaaattg 180 gacagcaaga aagcgagtta tcagtttttg tattggaagg gctcgtcgcc agtctcattg 240 agaaggcatg tgcggacgat ggcttctgtc actgcaaagg ggtcacaatt ggcagagggg 300 cggcgatctt caaagtaacc tttcttctcc tggccgacag tccggggaat gcggatgctg 360 gcactgcgat tggcgacacc agcagaaaag tcgttgatgt tggacgtttc gtggaaccca 420 gtcagacgac gggcattgtc caggcccccc ttgggatcgt aggctcgaat gtggtaccgg 480 tgccgcttgc ttagtttctc gatggcctcc tcgatgtgct tcagaccatt ctcctcccgc 540 atggccttgg tgctaaagtt ggtatggcag cctgcaccat tccagttccc aggaatgggc 600 ttggggtcaa aggttgctat taccccaaag tcctcacata ctcgatgcaa gatgaaacgg 660 gccacccaga gatgatctcc catgcggatt ccttcacagg gtcctatttg gaactcccac 720 tgggcaggca tgacctcagc atttgttcct gtaatcttga ccccagcata caagcaggcg 780 cggtagtgag cctccacgat atccctgcca taggctttgt ctgcgcccac accacagtaa 840 tacggacctt ggggcccagg aaagccattg gaaggccaac caaaagggtg cccatctgtt 900 cccatcagag tatactcctg ttccattcca aaccaggggt gctggttgct caccatgtcc 960 attatccgtt tacacgagtg ccttaaattt gtctctgcag gcttccggtt gtacttgaaa 1020 acttcacaga acaccagctt gttgggatct ctgcggaagg ggtcccgaaa catggcaaca 1080 gggctgagat acatgtcact gttggagccc tcagactgaa aggtactaga gccatcaaaa 1140 ttccactcag gtaactcttc tacacacttg ggctcacagt ccagggtgcg ggttttgcag 1200 cgcagtcctt ctccagtacc atcaacccag atatacatgg cttggacttt ctcaccctgg 1260 ggcaggcaca agtacatttg cttgatgttt ttgttcaagt gggaacttgc tgaggtggcc 1320 atggggccgg gattttcctc cacgtccccg catgttagca gacttcccct gccctcagat 1380 gtaccggcac cgggcttgcg ggtcatgcac caggtgcgcg gtccttcggg cacctcgacg 1440 tcggcggtga cggtgaagcc gagccgctcg tagaagggga ggttgcgggg cgcggatgtc 1500 tccaggaagg cgggcacccc ggcgcgctcg gccgcctcca ctccggggag cacgacggcg 1560 ctgcccagac ccttgccctg gtggtcgggc gacacgccga cggtggccag gaaccacgcg 1620 ggctccttgg gccggtgcgg cgccaggagg ccttccatct gttgctgcgc ggccagccgg 1680 gaaccgctca actcggccat gcgcgggccg atctcggcga acaccgcccc cgcttcgacg 1740 ctctccggcg tggtccagac cgccaccgcg gcgccgtcgt ccgcgaccca caccttgccg 1800 atgtcgagcc cgacgcgcgt gaggaagagt tcttgcagct cggtgacccg ctcgatgtgg 1860 cggtccggat cgacggtgtg gcgcgtggcg gggtagtcgg cgaacgcggc ggcgagggtg 1920 cgtacggccc tggggacgtc gtcgcgggtg gcgaggcgca ccgtgggctt gtactcggtc 1980 atggtggcgg ctctagacag cttgggtgta cctgcgaagc ccctgagacg gacgtgcgct 2040 ccggaggctt gcagaatgcg gaacaccgcg cgggcaggaa cagggcccac actaccgccc 2100 cacaccccgc ctcccgcacc gccccttccc ggccgctgct ctcagaaagc gaaggagcaa 2160 agctgctatt ggccgctgcc ccaaaggcct acccgcttcc attgctcagc ggtgctgtcc 2220 atctgcacga gactagtgag tcgtgctact tccatttgtc acgtcctgca cgacgcgagc 2280 tgcggg 2286 <210> 435 <211> 1296 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 435 cagcaggtgg gccgcctact gcgcacgcgc gggtttgcgg gcagccgcct gggctgtggg 60 agcagcccgg gcagagctct cctgcctctc caccagccca ccccgccgcc tgaccgcccc 120 ctccccaccc cccacccccc acccccggaa aacgcgtcgt cccctgggct gggtggagac 180 ccccgtcccg cgaaacaccg ggccccgcgc agcgtccggg cctgacaccg ctccggcggc 240 tcgcctccta tgcgcccccg cgccaccgtc gcccgcccgc ccgggcccct gcagccgccc 300 aggtgccagc acggagcgcc tggcggcgga acgcagaccc caggcccggc gcacaccggg 360 gacgctgagc gttccaggcg ggagggaagg cgggcagaga tggagagagg aacgggagac 420 ctagaggggc ggaaggacgg gcggagggac gttaggaggg agggagggag gcagggaggc 480 agggaggaac ggagggaaag acagagcgac gcagggactg ggggcgggcg ggagggagcc 540 ggggaacggg gggaggaagg cagggaggaa aagcggtcct cggcctccgg gagtagcggg 600 acccccgccc tccgggaaaa cggtcagcgt ccggcgcggg ctgagggctg ggcccacagc 660 cgccgcgccg gccggcgggg caccacccat tcgccccggt tccgtggccc agggagtggg 720 cggtttcctc cgggacaaaa gaccgggact cgggttgccg tcgggtcttc acccgcgcgg 780 ttcacagacc gcacatcccc aggctgagcc ctgcaacgcg gcgcgaggcc gacagccccg 840 gccacggagg agccacacgc aggacgacgg aggcgtgatt ttggtttccg cgtggctttg 900 ccctccgcaa ggcggcctgt tgctcacgtc tctccggccc ccgaaaggct ggccatgccg 960 actgtttgct cccggagctc tgcgggcacc cggaaacatg cagggaaggg tgcaagcccg 1020 gcacggtgcc ttcgctctcc ttgccaggtt ccaaaccggc cacactgcag actccccacg 1080 ttgccgcacg cgggaatcca tcgtcaggcc atcacgccgg ggaggcatct cctctctggg 1140 gtctcgctct ggtcttctac gtggaaatga acgagagcca cacgcctgcg tgtgcgagac 1200 cgtcccggca acggcgacgc ccacaggcat tgcctccttc acggagagag ggcctggcac 1260 actcaagact cccacggagg ttcagttcca cactcc 1296 <210> 436 <211> 1296 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 436 caccaggtgg gccgcctact gcgcacgcgc gggtttgcgg gcagccgcct gggctgtggg 60 agcagcccgg gcagagctct cctgcctctc caccagccca ccccgccgcc tgaccgcccc 120 ctccccaccc cccacccccc acccccggaa aacgcgtcgt cccctgggct gggtggtgac 180 ccccgtcccg cgaaacaccg ggccccgcgc agcgtccggg cctgacaccg ctccggcggc 240 tcgcctccta tgcgcccccg cgccaccgtc gcccgcccgc ccgggcccct gcagccgccc 300 aggtgccagc acggagcgcc tggcggcgga acgcagaccc caggcccggc gcacaccggg 360 gacgctgagc gttccaggcg ggagggaagg cgggcagaga tggagagagg aacgggagtc 420 ctagaggggc ggaaggacgg gcggagggac gttaggaggg agggagggag gcagggaggc 480 agggaggaac ggagggaaag acagagcgac gcagggactg ggggcgggcg ggagggagcc 540 ggggaacggg gggaggaagg cagggaggaa aagcggtcct cggcctccgg gagtagcggg 600 acccccgccc tccgggaaaa cggtcagcgt ccggcgcggg ctgagggctg ggcccacagc 660 cgccgcgccg gccggcgggg caccacccat tcgccccggt tccgtggccc agggagtggg 720 cggtttcctc cgggacaaaa gaccgggact cgggttgccg tcgggtgttc acccgcgcgg 780 ttcacagacc gcacatcccc aggctgagcc ctgcaacgcg gcgcgaggcc gacagccccg 840 gccacggagg agccacacgc aggacgacgg aggcgtgatt ttggtttccg cgtggctttg 900 ccctccgcaa ggcggcctgt tgctcaagtc tctccggccc ccgaaaggct ggccatgccg 960 actgtttgct cccggagctc tgcgggcacc cggaaacatg cagggaaggg tgcaagcccg 1020 gcacggtgcc ttcgctctcc ttgccaggtt ccaaaccggc cacactgcag actccccacg 1080 ttgccgcacg cgggaatcca tcgtcaggcc atcacgccgg ggaggcatct cctctctggg 1140 gtgtcgctct ggacttctac gtggaaatga acgagagcca cacgcctgcg tgtgccagac 1200 cgtcccggca acggcgacgc ccacaggcat tgcctccttc acggagagag ggcctggcac 1260 actcaagact cccacggagg ttcagttcca cactcc 1296 <210> 437 <211> 433 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 437 ggcgggaggg aaggcgggca gagatggaga gaggaacggg agacctagag gggcggaagg 60 acgggcggag ggacgttagg agggagggag ggaggcaggg aggcagggag gaacggaggg 120 aaagacagag cgacgcaggg actgggggcg ggcgggaggg agccggggaa cggggggagg 180 aaggcaggga ggaaaagcgg tcctcggcct ccgggagtag cgggaccccc gccctccggg 240 aaaacggtca gcgtccggcg cgggctgagg gctgggccca cagccgccgc gccggccggc 300 ggggcaccac ccattcgccc cggttccgtg gcccagggag tgggcggttt cctccgggac 360 aaaagaccgg gactcgggtt gccgtcgggt cttcacccgc gcggttcaca gaccgcacat 420 ccccaggctg agc 433 <210> 438 <211> 433 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 438 ggcgggaggg aaggcgggca gagatggaga gaggaacggg agtcctagag gggcggaagg 60 acgggcggag ggacgttagg agggagggag ggaggcaggg aggcagggag gaacggaggg 120 aaagacagag cgacgcaggg actgggggcg ggcgggaggg agccggggaa cggggggagg 180 aaggcaggga ggaaaagcgg tcctcggcct ccgggagtag cgggaccccc gccctccggg 240 aaaacggtca gcgtccggcg cgggctgagg gctgggccca cagccgccgc gccggccggc 300 ggggcaccac ccattcgccc cggttccgtg gcccagggag tgggcggttt cctccgggac 360 aaaagaccgg gactcgggtt gccgtcgggt gttcacccgc gcggttcaca gaccgcacat 420 ccccaggctg agc 433 <210> 439 <211> 65 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 439 agaggggcgg aagggacgtt aggagggagg cagggaggca gggaggcagg gaggaacgga 60 gggag 65 <210> 440 <211> 1213 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 440 gcgagctcac ggggacagcc cccccccaaa gcccccaggg atgtaattac gtccctcccc 60 cgctaggggg cagcagcgag ccgcccgggg ctccgctccg gtccggcgct ccccccgcat 120 ccccgagccg gcagcgtgcg gggacagccc gggcacgggg aaggtggcac gggatcgctt 180 tcctctgaac gcttctcgct gctctttgag cctgcagaca cctgggggga tacggggaaa 240 aagctttagg ctgaaagaga gatttagaat gacagaatca tagaacggcc tgggttgcaa 300 aggagcacag tgctcatcca gatccaaccc cctgctatgt gcagggtcat caaccagcag 360 cccaggctgc ccagagccac atccagcctg gccttgaatg cctgcaggga tggggcatcc 420 acagcctcct tgggcaacct gttcagtgcg tcaccaccct ctgggggaaa aactgcctcc 480 tcatatccaa cccaaacctc ccctgtctca gtgtaaagcc attccccctt gtcctatcaa 540 gggggagttt gctgtgacat tgttggtctg gggtgacaca tgtttgccaa ttcagtgcat 600 cacggagagg cagatcttgg ggataaggaa gtgcaggaca gcatggacgt gggacatgct 660 ggtgttgagg gctctgggac actctccaag tcacagcgtt cagaacagcc ttaaggataa 720 gaagatagga tagaaggaca aagagcaagt taaaacccag catggagagg agcacaaaaa 780 ggccacagac actgctggtc cctgtgtctg agcctgcatg tttgatggtg tctggatgca 840 agcagaaggg gtggaagtgc ttgcctggag agatacagct gggtcagtag gactgggaca 900 ggcagctgga gaattgccat gtagatgttc atacaatcgt caaatcatga aggctggaaa 960 agccctccaa gatccccaag accaacccca acccacccac cgtgcccact ggccatgtcc 1020 ctcagtgcca catccccaca gttcttcatc acctccaggg acggtgaccc ccccacctcc 1080 gtgggcagct gtgccactgc agcaccgctc tttggagaag gtaaatcttg ctaaatccag 1140 cccgaccctc ccctggcaca acgtaaggcc attatctctc atccaactcc aggacggagt 1200 cagtgagaat att 1213 <210> 441 <211> 246 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 441 gcgagctcac ggggacagcc cccccccaaa gcccccaggg atgtaattac gtccctcccc 60 cgctaggggg cagcagcgag ccgcccgggg ctccgctccg gtccggcgct ccccccgcat 120 ccccgagccg gcagcgtgcg gggacagccc gggcacgggg aaggtggcac gggatcgctt 180 tcctctgaac gcttctcgct gctctttgag cctgcagaca cctgggggga tacggggaaa 240 aagctt 246 <210> 442 <211> 1536 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 442 ctgttctcat cacatcatat caaggttata taccatcaat attgccacag atgttactta 60 gccttttaat atttctctaa tttagtgtat atgcaatgat agttctctga tttctgagat 120 tgagtttctc atgtgtaatg attatttaga gtttctcttt catctgttca aatttttgtc 180 tagttttatt ttttactgat ttgtaagact tctttttata atctgcatat tacaattctc 240 tttactgggg tgttgcaaat attttctgtc attctatggc ctgacttttc ttaatggttt 300 tttaatttta aaaataagtc ttaatattca tgcaatctaa ttaacaatct tttctttgtg 360 gttaggactt tgagtcataa gaaatttttc tctacactga agtcatgatg gcatgcttct 420 atattatttt ctaaaagatt taaagttttg ccttctccat ttagacttat aattcactgg 480 aatttttttg tgtgtatggt atgacatatg ggttcccttt tattttttac atataaatat 540 atttccctgt ttttctaaaa aagaaaaaga tcatcatttt cccattgtaa aatgccatat 600 ttttttcata ggtcacttac atatatcaat gggtctgttt ctgagctcta ctctatttta 660 tcagcctcac tgtctatccc cacacatctc atgctttgct ctaaatcttg atatttagtg 720 gaacattctt tcccattttg ttctacaaga atatttttgt tattgtcttt gggctttcta 780 tatacatttt gaaatgaggt tgacaagtta ataacaggcc tattgattgg aaagtttgtc 840 aacgaattgt gggtcttttg gggtttgctg ccccttttac gcaatgtgga tatcctgctt 900 taatgccttt atatgcatgt atacaagcaa aacaggcttt tactttctcg ccaacttaca 960 aggcctttct cagtaaacag tatatgaccc tttaccccgt tgctcggcaa cggcctggtc 1020 tgtgccaagt gtttgctgac gcaaccccca ctggttgggg cttggccata ggccatcagc 1080 gcatgcgtgg aacctttgtg tctcctctgc cgatccatac tgcggaactc ctagccgctt 1140 gttttgctcg cagcaggtct ggagcaaacc tcatcgggac cgacaattct gtcgtactct 1200 cccgcaagta tacatcgttt ccatggctgc taggctgtgc tgccaactgg atcctgcgcg 1260 ggacgtcctt tgtttacgtc ccgtcggcgc tgaatcccgc ggacgacccc tcccggggcc 1320 gcttggggct ctaccgcccg cttctccgtc tgccgtaccg tccgaccacg gggcgcacct 1380 ctctttacgc ggactccccg tctgtgcctt ctcatctgcc ggaccgtgtg cacttcgctt 1440 cacctctgca cgtcgcatgg aggccaccgt gaacgcccac cggaacctgc ccaaggtctt 1500 gcataagagg actcttggac tttcagcaat gtcatc 1536 <210> 443 <211> 726 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 443 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagctggact ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatc 726 <210> 444 <211> 726 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 444 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagcaggtct ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacctgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatc 726 <210> 445 <211> 810 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 445 ctgttctcat cacatcatat caaggttata taccatcaat attgccacag atgttactta 60 gccttttaat atttctctaa tttagtgtat atgcaatgat agttctctga tttctgagat 120 tgagtttctc atgtgtaatg attatttaga gtttctcttt catctgttca aatttttgtc 180 tagttttatt ttttactgat ttgtaagact tctttttata atctgcatat tacaattctc 240 tttactgggg tgttgcaaat attttctgtc attctatggc ctgacttttc ttaatggttt 300 tttaatttta aaaataagtc ttaatattca tgcaatctaa ttaacaatct tttctttgtg 360 gttaggactt tgagtcataa gaaatttttc tctacactga agtcatgatg gcatgcttct 420 atattatttt ctaaaagatt taaagttttg ccttctccat ttagacttat aattcactgg 480 aatttttttg tgtgtatggt atgacatatg ggttcccttt tattttttac atataaatat 540 atttccctgt ttttctaaaa aagaaaaaga tcatcatttt cccattgtaa aatgccatat 600 ttttttcata ggtcacttac atatatcaat gggtctgttt ctgagctcta ctctatttta 660 tcagcctcac tgtctatccc cacacatctc atgctttgct ctaaatcttg atatttagtg 720 gaacattctt tcccattttg ttctacaaga atatttttgt tattgtcttt gggctttcta 780 tatacatttt gaaatgaggt tgacaagtta 810 <210> 446 <211> 155 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 446 ggcatgcttc tatattattt tctaaaagat ttaaagtttt gccttctcca tttagactta 60 taattcactg gaattttttt gtgtgtatgg tatgacatat gggttccctt ttatttttta 120 catataaata tatttccctg tttttctaaa aaaga 155 <210> 447 <211> 300 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 447 ggttcccttt tattttttac atataaatat atttccctgt ttttctaaaa aagaaaaaga 60 tcatcatttt cccattgtaa aatgccatat ttttttcata ggtcacttac atatatcaat 120 gggtctgttt ctgagctcta ctctatttta tcagcctcac tgtctatccc cacacatctc 180 atgctttgct ctaaatcttg atatttagtg gaacattctt tcccattttg ttctacaaga 240 atatttttgt tattgtcttt gggctttcta tatacatttt gaaatgaggt tgacaagtta 300 <210> 448 <211> 1454 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 448 aagctttaga ctctgggtag aatgttctgt ttcctgtaat ataaaatcat aaagtgatga 60 tattatcaag tgaaaaggaa atgtggtacc ttaatctttc cacatcaagc caatatcatg 120 ctgaaggcca gagaatcttt tttgctaaaa aacacaatac agatataatt aatagttatc 180 atttatgttt gatattaatc atatgaatat aattaatatg ttttattgta tcgattattg 240 ttgatattaa tgtaattact actaatacat aacaaatata actaatggtt atggctcagt 300 aactaaggta agatataagc tacactggta aagaaagatc aatattgctt cagagtacac 360 tgaagtaaat gaataactta accggtctag gttgtcactt atatttatac aacattttaa 420 gaactaagaa cctctcttct atgcttagta gatgaacaaa atcatgtaat agatgaatga 480 ggccaggaag tacaaaggtt tacaaaattg ccaagccact ctggggtgat tttatgagta 540 atgcggcatt tggtagcttg ccttaaagaa tattattgga cattatcaag tgtgtgtgtg 600 tgtgtgtgtg tgtgtgtgtg tgtgtgtaac tgaactctct tgtagtttca tttttgtttg 660 aaaaagacat gtatctcatg tagcccaggc tggaatcaaa ctctatcctt ctgtctccac 720 ctctcaggtt ctggggttcc tggcatgcag cacccaagcc cagctacctc tgtgaaaact 780 ataacttagt aatcagatcc tggaccattt aaagaatata tatatatgta tgtgtgtgtg 840 tgtgtatata tataatatat acatatgtat gtatatatac atatatatgt atgtgtatat 900 atgtatgtat agagaggctg actatatata tatatatata tatgaggctg aatatatata 960 tatatatgaa tacacataca catagtgcca tggcacattc ctttaatctg agctctcagg 1020 caaaggcaga ccaatctctg agttgttcaa ggccagtgtg atccatagtc tcagaaatta 1080 tatactgaga cactcctgag gatgttatca catttctagt ttccttatct tactttagga 1140 catgattcca aaaaaaaggg gggggggaca cacagtcaat ggtagagtta caagactatg 1200 ccgatgtggt gactcaagaa gagagggctg agggagctga aacaggcatg ttcccatgaa 1260 ttccgggcaa gcctaggcta tagagtgaga ccaccatgat ttaaaaaaaa aaaaaaagtg 1320 gcacgcgaga aagtcaacaa tgctttgcat aagtgtttta cctcaaaatc gctgaatagt 1380 tgactagaac aaattaaaac cttgtccaaa gtcaaggcca gtgggatcag ggactccctc 1440 cagtcctgaa gctt 1454 <210> 449 <211> 1260 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 449 tagactctgg gtagaatgtt ctgtttcctg taatataaaa tcataaagtg atgatattat 60 caagtgaaaa ggaaatgtgg taccttaatc tttccacatc aagccaatat catgctgaag 120 gccagagaat cttttttgct aaaaaacaca atacagatat aattaatagt tatcatttat 180 gtttgatatt aatcatatga atataattaa tatgttttat tgtatcgatt attgttgata 240 ttaatgtaat tactactaat acataacaaa tataactaat ggttatggct cagtaactaa 300 ggtaagatat aagctacact ggtaaagaaa gatcaatatt gcttcagagt acactgaagt 360 aaatgaataa cttaaccggt ctaggttgtc acttatattt atacaacatt ttaagaacta 420 agaacctctc ttctatgctt agtagatgaa caaaatcatg taatagatga atgaggccag 480 gaagtacaaa ggtttacaaa attgccaagc cactctgggg tgattttatg agtaatgcgg 540 catttggtag cttgccttaa agaatattat tggacattat caagtgtgtg tgtgtgtgtg 600 tgtgtgtgtg tgtgtgtgtg taactgaact ctcttgtagt ttcatttttg tttgaaaaag 660 acatgtatct catgtagccc aggctggaat caaactctat ccttctgtct ccacctctca 720 ggttctgggg ttcctggcat gcagcaccca agcccagcta cctctgtgaa aactataact 780 tagtaatcag atcctggacc atttaaagaa tatatatata tgtatgtgtg tgtgtgtgta 840 tatatataat atatacatat gtatgtatat atacatatat atgtatgtgt atatatgtat 900 gtatagagag gctgactata tatatatata tatatatgag gctgaatata tatatatata 960 tgaatacaca tacacatagt gccatggcac attcctttaa tctgagctct caggcaaagg 1020 cagaccaatc tctgagttgt tcaaggccag tgtgatccat agtctcagaa attatatact 1080 gagacactcc tgaggatgtt atcacatttc tagtttcctt atcttacttt aggacatgat 1140 tccaaaaaaa aggggggggg gacacacagt caatggtaga gttacaagac tatgccgatg 1200 tggtgactca agaagagagg gctgagggag ctgaaacagg catgttccca tgaattccgg 1260 <210> 450 <211> 404 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 450 tagactctgg gtagaatgtt ctgtttcctg taatataaaa tcataaagtg atgatattat 60 caagtgaaaa ggaaatgtgg taccttaatc tttccacatc aagccaatat catgctgaag 120 gccagagaat cttttttgct aaaaaacaca atacagatat aattaatagt tatcatttat 180 gtttgatatt aatcatatga atataattaa tatgttttat tgtatcgatt attgttgata 240 ttaatgtaat tactactaat acataacaaa tataactaat ggttatggct cagtaactaa 300 ggtaagatat aagctacact ggtaaagaaa gatcaatatt gcttcagagt acactgaagt 360 aaatgaataa cttaaccggt ctaggttgtc acttatattt atac 404 <210> 451 <211> 691 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 451 tagactctgg gtagaatgtt ctgtttcctg taatataaaa tcataaagtg atgatattat 60 caagtgaaaa ggaaatgtgg taccttaatc tttccacatc aagccaatat catgctgaag 120 gccagagaat cttttttgct aaaaaacaca atacagatat aattaatagt tatcatttat 180 gtttgatatt aatcatatga atataattaa tatgttttat tgtatcgatt attgttgata 240 ttaatgtaat tactactaat acataacaaa tataactaat ggttatggct cagtaactaa 300 ggtaagatat aagctacact ggtaaagaaa gatcaatatt gcttcagagt acactgaagt 360 aaatgaataa cttaaccggt ctaggttgtc acttatattt atacaacatt ttaagaacta 420 agaacctctc ttctatgctt agtagatgaa caaaatcatg taatagatga atgaggccag 480 gaagtacaaa ggtttacaaa attgccaagc cactctgggg tgattttatg agtaatgcgg 540 catttggtag cttgccttaa agaatattat tggacattat caagtgtgtg tgtgtgtgtg 600 tgtgtgtgtg tgtgtgtgtg taactgaact ctcttgtagt ttcatttttg tttgaaaaag 660 acatgtatct catgtagccc aggctggaat c 691 <210> 452 <211> 1454 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 452 aagctttaga ctctgggtag aatgttctgt ttcctgtaat ataaaatcat aaagtgatga 60 tattatcaag tgaaaaggaa atgtggtacc ttaatctttc cacatcaagc caatatcatg 120 ctgaaggcca gagaatcttt tttgctaaaa aacacaatac agatataatt aatagttatc 180 atttatgttt gatattaatc atatgaatat aattaatatg ttttattgta tcgattattg 240 ttgatattaa tgtaattact actaatacat aacaaatata actaatggtt atggctcagt 300 aactaaggta agatataagc tacactggta aagaaagatc aatattgctt cagagtacac 360 tgaagtaaat gaataactta accggtctag gttgtcactt atatttatac aacattttaa 420 gaactaagaa cctctcttct atgcttagta gatgaacaaa atcatgtaat agatgaatga 480 ggccaggaag tacaaaggtt tacaaaattg ccaagccact ctggggtgat tttatgagta 540 atgcggcatt tggtagcttg ccttaaagaa tattattgga cattatcaag tgtgtgtgtg 600 tgtgtgtgtg tgtgtgtgtg tgtgtgtaac tgaactctct tgtagtttca tttttgtttg 660 aaaaagacat gtatctcatg tagcccaggc tggaatcaaa ctctatcctt ctgtctccac 720 ctctcaggtt ctggggttcc tggcatgcag cacccaagcc cagctacctc tgtgaaaact 780 ataacttagt aatcagatcc tggaccattt aaagaatata tatatatgta tgtgtgtgtg 840 tgtgtatata tataatatat acatatgtat gtatatatac atatatatgt atgtgtatat 900 atgtatgtat agagaggctg actatatata tatatatata tatgaggctg aatatatata 960 tatatatgaa tacacataca catagtgcca tggcacattc ctttaatctg agctctcagg 1020 caaaggcaga ccaatctctg agttgttcaa ggccagtgtg atccatagtc tcagaaatta 1080 tatactgaga cactcctgag gatgttatca catttctagt ttccttatct tactttagga 1140 catgattcca aaaaaaaggg gggggggaca cacagtcaat ggtagagtta caagactatg 1200 ccgatgtggt gactcaagaa gagagggctg agggagctga aacaggcatg ttcccatgaa 1260 ttccgggcaa gcctaggcta tagagtcaga ccaccatgat ttaaaaaaaa aaaaaaagtg 1320 gcacgcgaga aagtcaacaa tgctttgcat aagtgtttta cctcaaaatc gctgaatagt 1380 tgactagaac aaattaaaac cttgtccaaa gtcaaggcca gtgggatcag ggactccctc 1440 cagtcctgaa gctt 1454 <210> 453 <211> 293 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 453 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca 293 <210> 454 <211> 364 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 454 actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc 60 cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca 120 ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt 180 caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg 240 ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag 300 tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt 360 acca 364 <210> 455 <211> 375 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 455 attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 60 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 120 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 180 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 240 tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 300 attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag 360 tcatcgctat tacca 375 <210> 456 <211> 375 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 456 attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 60 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 120 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 180 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 240 tgtatcatat gccaagtccg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 300 attatgccca gtacatgacc ttacgggact ttcctacttg gcagtacatc tacgtattag 360 tcatcgctat tacca 375 <210> 457 <211> 374 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 457 attgattatt gagtagttat taatagtaat caattacggg gtcattagtt catagcccat 60 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 120 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 180 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 240 tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 300 attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacggttagt 360 catcgctatt acca 374 <210> 458 <211> 305 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 458 ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc 60 attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg 120 tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat 180 gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca 240 gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat 300 tacca 305 <210> 459 <211> 275 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 459 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 120 ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga 180 cggtaaatgg cccgcctggc attgtgccca gtacatgacc ttatgggact ttcctacttg 240 gcagtacatc tacgtattag tcatcgctat tacca 275 <210> 460 <211> 293 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 460 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca 293 <210> 461 <211> 292 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 461 actacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 60 atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 120 tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 180 cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 240 tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac ca 292 <210> 462 <211> 293 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 462 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta cca 293 <210> 463 <211> 412 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 463 gtcagtgtac ttggctccaa tgggtttttc ccattgactc atcccctatt gaccttatgt 60 actgggcaaa acccaatgga aagtccctat tgacgcagtg tacttggctc caatgggact 120 ttcctgttga ttcaccccct attgacctta tgtactgggc agaatacaat ggaaagtccc 180 tattgactca cccacattga ccttatatgc ttgccaacaa tggaaaaacc cattggaaag 240 tccctattga gtcagtgtac ttggcagcaa tgggtttttc ccattggctc acctcccatt 300 gacccaatgt acttgggcaa aacccagtgg aaagtcccat ttgactcagt gtgcttgcca 360 gtaatgggaa aaacccattg gcttacctcc cattgaccca atgtacttgg gt 412 <210> 464 <211> 294 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 464 tgagtcaata gggactttcc aatgggtttt gcccagtaca taaggtcaat gggaggtaag 60 ccaatgggtt tttcccatta ctggcacgta tactgagtca ttagggactt tccaatgggt 120 tttgcccagt acataaggtc aataggggtg aatcaacagg aaagttccat tggagccaag 180 tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg tcaatagggg 240 gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg ggtg 294 <210> 465 <211> 423 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 465 gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg 60 ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc 120 caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg 180 ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt 240 ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt 300 ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt 360 caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg 420 gtg 423 <210> 466 <211> 412 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 466 gtcagtgtac ttggctccaa tgggtttttc ccattgactc atcccctatt gaccttatgt 60 actgggcaaa acccaatgga aagtccctat tgacgcagtg tacttggctc caatgggact 120 ttcctgttga ttcaccccct attgacctta tgtactgggc agaatacaat ggaaagtccc 180 tattgactca cccacattga ccttatatgc ttgccaacaa tggaaaaacc cattggaaag 240 tccctattga gtcagtgtac ttggcagcaa tgggtttttc ccattggctc acctcccatt 300 gacccaatgt acttgggcaa aacccagtgg aaagtcccat ttgactcagt gtgcttgcca 360 gtaatgggaa aaacccattg gcttacctcc cattgaccca atgtacttgg gt 412 <210> 467 <211> 294 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 467 tgagtcaata gggactttcc aatgggtttt gcccagtaca taaggtcaat gggaggtaag 60 ccaatgggtt tttcccatta ctggcacgta tactgagtca ttagggactt tccaatgggt 120 tttgcccagt acataaggtc aataggggtg aatcaacagg aaagttccat tggagccaag 180 tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg tcaatagggg 240 gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg ggtg 294 <210> 468 <211> 423 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 468 gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg 60 ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc 120 caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg 180 ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt 240 ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt 300 ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt 360 caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg 420 gtg 423 <210> 469 <211> 206 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 469 tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg tcaatagggg 60 tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg actttccatt 120 gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt cccattattg 180 gcacgtacat aaggtcaata ggggtg 206 <210> 470 <211> 106 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 470 ccattggagc caagtacact gagtcaatag ggactttcca ttgggttttg cccagtacaa 60 aaggtcaata gggggtgagt caatgggttt ttcccattat tggcac 106 <210> 471 <211> 292 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 471 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt at 292 <210> 472 <211> 102 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 472 ccagctgttg gggtgagtac tccctctcaa aagcgggcat tacttctgcg ctaagattgt 60 cagtttccaa aaacgaggag gatttgatat tcacctggcc cg 102 <210> 473 <211> 144 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 473 ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt 60 agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca 120 tgcatctcaa ttagtcagca acca 144 <210> 474 <211> 178 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 474 gcacatcgcc cacagtcccc gagaagttgg ggggaggctc tggctgcagg taattgaacc 60 ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc 120 ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttc 178 <210> 475 <211> 369 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 475 acccgccccg accggagctg agagtaattc atacaaaagg actcgcccct gccttgggga 60 atcccaggga ccgtcgttaa actcccacta acgtagaacc cagagatcgc tgcgttcccg 120 ccccctcacc cgcccgctct cgtcatcact gaggtggaga atagcatgcg tgaggctccg 180 gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg ggaggggtcg 240 gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt 300 actggctcag cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg 360 tgaacgttc 369 <210> 476 <211> 369 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 476 acccgccccg accggagctg agagtaattc atacaaaagg actcgcccct gccttgggga 60 atcccaggga ccgtcgttaa actcccacta acgtagaacc cagagatcgc tgcgttcccg 120 ccccctcacc cgcccgctct cgtcatcact gaggtggaga atagcatgcg tgaggctccg 180 gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg ggaggggtcg 240 gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt 300 actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg 360 tgaacgttc 369 <210> 477 <211> 372 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 477 acccgccccg accggagctg agagtaattc atacaaaagg actcgcccct gccttgggga 60 atcccaggga ccgtcgttaa actcccacta acgtagaacc cagagatcgc tgcgttcccg 120 ccccctcacc cgcccgctct cgtcatcact gaggtggaga atagcatgcg tgaggctccg 180 gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg 240 tcggcaattg aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg 300 tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg 360 ccgtgaacgt tc 372 <210> 478 <211> 372 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 478 acccgccccg accggagctg agagtaattc atacaaaagg actcgcccct gccttgggga 60 atcccaggga ccgtcgttaa actcccacta acgtagaacc cagagatcgc tgcgttcccg 120 ccccctcacc cgcccgctct cgtcatcact gaggtggaga atagcatgcg tgaggctccg 180 gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg 240 tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg 300 tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg 360 ccgtgaacgt tc 372 <210> 479 <211> 372 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 479 acccgccccg accggagctg agagtaattc atacaaaagg actcgcccct gccttgggga 60 atcccaggga ccgtcgttaa actcccacta acgtagaacc cagagatcgc tgcgttcccg 120 ccccctcacc cgcccgctct cgtcatcact gaggtggaga atagcatgcg tgaggctccg 180 gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg 240 tcggcaattg atccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg 300 tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg 360 ccgtgaacgt tc 372 <210> 480 <211> 570 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 480 ctgggctgag acccgcagag gaagacgctc tagggatttg tcccggacta gcgagatggc 60 aaggctgagg acgggaggct gattgagagg cgaaggtaca ccctaatctc aatacaacct 120 ttggagctaa gccagcaatg gtagagggaa gattctgcac gtcccttcca ggcggcctcc 180 ccgtcaccac cccccccaac ccgccccgac cggagctgag agtaattcat acaaaaggac 240 tcgcccctgc cttggggaat cccagggacc gtcgttaaac tcccactaac gtagaaccca 300 gagatcgctg cgttcccgcc ccctcacccg cccgctctcg tcatcactga ggtggagaag 360 agcatgcgtg aggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 420 agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa 480 actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 540 atataagtgc agtagtcgcc gtgaacgttc 570 <210> 481 <211> 168 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 481 gcacatcgcc cacagtcccc gagaagttgg gaggggtcgg caattgaacc ggtgcctaga 60 gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg 120 agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttc 168 <210> 482 <211> 171 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 482 gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct 60 agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc 120 ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt c 171 <210> 483 <211> 171 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 483 gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga acgggtgcct 60 agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc 120 ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt c 171 <210> 484 <211> 168 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 484 gcacatcgcc cacagtcccc gagaagttgg gaggggtcgg caattgaacc ggtgcctaga 60 gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctcagc ctttttcccg 120 agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttc 168 <210> 485 <211> 171 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 485 gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga tccggtgcct 60 agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc 120 ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt c 171 <210> 486 <211> 440 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 486 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 60 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 120 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 180 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 240 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 300 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 360 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 420 cggcagtcgc cttggacgtt 440 <210> 487 <211> 480 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 487 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 60 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 120 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 180 cctggggaag tcccagggac cgtcgctaaa ttctcataac ccataatccc ggtacccgcc 240 ccaccacagt gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 300 ctcatagacc ctggtcgtgg ggggaggggc gcactgagcg gggggggggg gggtgatggg 360 ggggaggacc ggggagctgg cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc 420 gccctcttcc cgagggtggg ggagaacggt atataagtgc ggcagtcgcc ttggacgttc 480 <210> 488 <211> 316 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 488 ggagccgaga gtaattcata caaaaggagg gatcgccttc gcaaggggag agcccaggga 60 ccgtccctaa attctcacag acccaaatcc ctgtagccgc cccacgacag cgcgaggagc 120 atgcgcccag ggctgagcgc gggtagatca gagcacacaa gctcacagtc cccggcggtg 180 gggggagggg cgcgctgagc gggggccagg gagctggcgc ggggcaaact gggaaagtgg 240 tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata taagtgcggt 300 agtcgccttg gacgtt 316 <210> 489 <211> 503 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 489 cctctcccgg ccagaggagc aaggtatgcg ggaggcgacc aggaggatag cggggctgac 60 gtcgggaggt ggcctccgtg ggaaggacac ccggatcttg acacagcctt ggcagcggag 120 tcaggaagag taggggtagg ttctggacgc cctcttggcc agctcatcgc cgccccaccc 180 tctgctggag cacagagtaa ttcatacaaa aggagggatc gccttcgcaa ggggagagcc 240 cagggaccgt ccctaaattc tcacagaccc aaatccctgt agccgcccca cgacagcgcg 300 aggagcatgc gcccagggct gagcgcgggt agatcagagc acacaagctc acagtccccg 360 gcggtggggg gaggggcgcg ctgagcgggg gccagggagc tggcgcgggg caaactggga 420 aagtggtgtc gtgtgctggc tccgccctct tcccgagggt gggggagaac ggtatataag 480 tgcggtagtc gccttggacg ttc 503 <210> 490 <211> 503 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 490 cctctcccgg ccagaggagc aaggtatgcg ggaggcgacc aggaggatag cggggctgac 60 gtcgggaggt ggcctccgtg ggaaggacac ccggatcttg acacagcctt ggcagcggag 120 tcaggaagag taggggtagg ttctggacgc cctcttggcc agctcttcgc cgccccaccc 180 tctgctggag cacagagtaa ttcatacaaa aggagggatc gccttcgcaa ggggagagcc 240 cagggaccgt ccctaaattc tcacagaccc aaatccctgt agccgcccca cgacagcgcg 300 aggagcatgc gcccagggct gagcgcgggt agatcagagc acacaagctc acagtccccg 360 gcggtggggg gaggggcgcg ctgagcgggg gccagggagc tggcgcgggg caaactggga 420 aagtggtgtc gtgtgctggc tccgccctct tcccgagggt gggggagaac ggtatataag 480 tgcggtagtc gccttggacg ttc 503 <210> 491 <211> 301 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 491 ggagccgaga gtaattcata caaaaggagg gatcgccttc gcaaggggag agcccaggga 60 ccgtccctaa attctcacag acccaaatcc ctgtagccgc cccacgacag cgcgaggagc 120 atgcgctcag ggctgagcgc ggggagagca gagcacacaa gctcatagac cctggtcgtg 180 ggggggagga ccggggagct ggcgcggggc aaactgggaa agcggtgtcg tgtgctggct 240 ccgccctctt cccgagggtg ggggagaacg gtatataagt gcggcagtcg ccttggacgt 300 t 301 <210> 492 <211> 459 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 492 ggcggggctg acgtcgggag gtggcctcca cgggaaggga cacccggatc tcgacacagc 60 cttggcagtg gagtcaggaa gggtaggaca gattctggac gccctcttgg ccagtcctca 120 ccgccccacc cccgatggag ccgagagtaa ttcatacaaa aggagggatc gccttcgccc 180 ctgggaatcc cagggaccgt cgctaaattc tggccggcct cccagcccgg aaccgctgtg 240 cccgcccagc gcggcgggag gagcctgcgc ctagggcgga tcgcgggtcg gcgggagagc 300 acaagcccac agtccccggc ggtgggggag gggcgcgctg agcgggggcc cgggagccag 360 cgcggggcaa actgggaaag tggtgtcgtg tgctggctcc gccctcttcc cgagggtggg 420 ggagaacggt ataaaagtgc ggtagtcgcg ttggacgtt 459 <210> 493 <211> 600 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 493 ggggactctg aaggcaaaga cggaggagga gcctgccccg ggcgcgtatg ggaccagcag 60 aagaagctgt tcaaggggtt tgtccaggac ccgcgagagg tcaaggctga ggacgggagg 120 cgtactgcgg ggtgaaggga taccccaacc tggataccat ctttgcaaag aaagcaggaa 180 cggtggaggg aagattctaa gcgtccccgc ctggccgtct actctccgcc ccacccccag 240 ctgcagctga gagtaattca tacaaaagga ggactcgcct tggcctcggg gaatcccagg 300 gaccgtcggt aaactcccac taacctagaa ccgagggctc gctcgtcccc gcctcccacc 360 ccgcgctctc gtcatcatcg gggtcgagag gagcatgcgc aaggcgacgg gtgcttttca 420 gtgggctgag cgcacatcgc ccacggtccc cgaaacgttg ggggagggga cggcgattga 480 acgggtgccc ggtggaggtg gcgcggggta aactgggaaa gtcgtgtcgt gtgctgactc 540 cgccctcttc ccgagggtgg gggaggaccg tatataagtg ccgtagtcct cttgaacgtt 600 <210> 494 <211> 451 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 494 gccaggggtg aggccaagac ccgcggcagg gcgaaggcac accccagtgt ccactcaacc 60 tctgtgctaa gccacgaaga aaaggaagat tctggactgc ctttctggcg attcctagcc 120 gccccacccc cggctggaac caggagtaat tcatacaaaa ggaggactcg cctctgccct 180 cgggaatccc agggaccgtc gataaattct cttaataccc gccccgcggc ctccgagtcg 240 aggagagcat gggccgccga actggttgcg gatcagggcg ccgagcccac agcatcacgg 300 tccccgaggg cgggggaggg gacggcaagg gagcaaggcc aggaggaggc ggcgcggggc 360 aaactgggaa agtggtgtcg tgtgctggct ccgccctctt tccgagggtg ggggagaacg 420 gtatataagt gccgtagtcg ccctggacgt t 451 <210> 495 <211> 525 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 495 gcctggtccg gggtgcgagc atcacgccta gaggctccca acgggccagg tggcaggtgg 60 gcgacagggg aaagggacac ctcactcttg gcggctgagc caggaacggc agaggaacat 120 tctgggcgcc cctactggcc ttttcctcgc cgccccattc ccgggtgaag ctgagagtaa 180 ttcatacaga agaactcgcc tttgcctcgg ggaatcccag ggaccgtggt taaactccca 240 ctaacttaaa agcgaaggat ctccggggcc ccgcccccgg ctctcgtcaa cctcggggtc 300 gagaggagca tgcgcaagga gctgggtacg ggtcagtggg ctcagcgcac atcgcccatg 360 gtccccgaga actggttggg gggaggggag aggggcggtg attgaacgag tgcctactgg 420 aggttgcgcg gtgtaaactg ggaaagtggt gtcgtgtgcg ggctccgccc tcttcccgag 480 ggtgggggag aaccgtatat aagtgccgta gtcgccctgg acgtt 525 <210> 496 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 496 tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg 220 <210> 497 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 497 tgctgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg 220 <210> 498 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 498 tagtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg 220 <210> 499 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 499 tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agcgcgcgtt tagtgaaccg 220 <210> 500 <211> 220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 500 tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg 220 <210> 501 <211> 314 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 501 agtcattggg tttttccagc catttaatta aaacgccatg tactttccca ccattgacgt 60 caatgggcta ttgaaactaa tgcaacgtga cctttaaacg gtactttccc atagctgatt 120 aatgggaaag taccgttctc gagccaatac acgtcaatgg gaagtgaaag ggcagccaaa 180 acgtaacacc gccccggttt tcccctggaa attccatatt ggcactcatt ctattggctg 240 agctgcgttc tacgtgggta taagaggcgc gaccagcgtc ggtaccgtcg cagtcttcgg 300 tctgaccacc gtag 314 <210> 502 <211> 313 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 502 agtcattggg tttttccagc caatttataa aacgccatgt actttcccac cattgacgtc 60 aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca tagctgatta 120 atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg gcagccaaaa 180 cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc tattggctga 240 gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc agtcttgggt 300 ctgaccaccg tag 313 <210> 503 <211> 315 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 503 agtcattggg tttttccagc caatttaatt aaaacgccat gtactttccc accattgacg 60 tcaatgggct attgaaacta atgcaacgtg acctttaaac ggtactttcc catagctgat 120 taatgggaaa gtaccgttct cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa 180 aacgtaacac cgccccggtt ttcccctgga aattccatat tggcacgcat tctattggct 240 gagctgcgtt ctacgtgggt ataagaggcg cgaccagcgt cggtaccgtc gcagtcttcg 300 gtctgaccac cgtag 315 <210> 504 <211> 283 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 504 agtcattggg tttttccagc caatttataa aacgccatgt actttcccac cattgacgtc 60 aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca tagctgatta 120 atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg gcagccaaaa 180 cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc tattggctga 240 gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gta 283 <210> 505 <211> 293 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 505 aaaggccatt gagtcaccac ccctatgctg ggaaatggtg aacgccccct atgtggaaag 60 tccctatggg ccgccattag agtgcatgac cgtgctgatt catatgccat atgagtgtat 120 tagggggctt tccgcgtggg aaattgggta aaaagtcccc gtattactca catagggggc 180 gtttggcttt gcaaattagg ggatttcagt gcatttggca ttaaaaacta ttggttctag 240 tcataaaacg ggcggagtta accatataat tgctgtcccc catgccattc gag 293 <210> 506 <211> 238 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 506 tactaatggg gatttccaat gactaataca acgggcagta cgcccagtac gtatgactaa 60 tgggactttc cataatcccg ccccattgac gtcaatgggc atccgttctg gcaccaaaat 120 gaatgggaat ttccaatatg agtcataaac cccgccccat tgacgcacat tacacgtcaa 180 tgggcggtag gcgtgcccta tgggcggtct atataagcag agcccgttta gtgaaccg 238 <210> 507 <211> 783 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 507 tattaatagc aatcttagct aattaaaata gatagcgttt attgagcgtt gggtatcagg 60 cacggtccta attcttttag atgtctttag ttcgtttcac tctcccccaa acaatagggt 120 ggtattgatc acctccgagc aggtgaaatt gaggcacaga gaaatcctag tagctggtag 180 aagaacacgc agtgtggtca agctagcaag gtgtttggtc cactgctata tctacaaaac 240 ccctaacaat gcctggtgta tagatgctca gtatgcattt gtgggatcag tgattccgat 300 gcctgcttct tataaagttt ttatttagaa ataattacag gtaaggagtt gcaaaaacag 360 tatagtggga tcgagtgtcc tttttccctc ggcttctccc aggggtatcg tcttacgtaa 420 caatgtccaa acagggaaat tgacttgggt ataatccaca gactctattc accttgtaga 480 ttggttttaa tagaagtaac tggacaactt gtaagctaat atcgttgcta tggttctcgt 540 tctcagctaa aacggcgctc tttactttgt gcacctgaac actgcacacc gagggcgacc 600 accgcccccg agatgcccag cttctattct agagcgccgc gccggcgccg aatgggttaa 660 cgggcggggg gacacgcctc cgtgcgcttg cgcggcgtcc cttcgccccg ccttcgcagc 720 gcagtcacat gacccgccca accggcgtcc gcctataaaa agctgagtgt tgacgtcagc 780 gtt 783 <210> 508 <211> 335 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 508 ggatccaact tctaagtccg ttttttattg atctaaaagg ccttttgcga atcatcttga 60 aggcaatcgc gttctgagcc acctcagctt tggcacacag cgcggggact gtcgcgaggg 120 gtttagggcc caagcaggac acaccccgaa atctccgcag ccacccccac cccacgcccc 180 cggctcttga gggttaaatc gcaggcgcag gttctcgcac gcgcacatca tcccgcaggc 240 gagccccagc acccagccca gggtgcgcgc gcgccgtcac gtgacacgcc caaccggcgt 300 cgccgtataa aagcgcgggc gttgacgtca gcggt 335 <210> 509 <211> 335 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 509 ggatccaact tctaagtccg ttttttattg atctaaaagg ccttttgcga atcatcttga 60 aggcaatcgc gttctgagcc acctcagctt tggcacacag cgcggggact gtcgcgaggg 120 gtttagggcc caagcaggac acaccccgaa atctccgcag ccacccccac cccacgcccc 180 cggctcttga gggttaaatc gcaggcgctg gttctcgcac gcgcacatca tcccgcaggc 240 gagccccagc acccagccca gggtgcgcgc gcgccgtcac gtgacacgcc caaccggcgt 300 cgccgtataa aagcgcgggc gttgacgtca gcgtt 335 <210> 510 <211> 343 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 510 tgacttgggt ataatccaca gactctattc accttgtaga ttggttttaa tagaagtaac 60 tggacaactt gtaagctaat atcgttgcta tggttctcgt tctcagctaa aacggcgctc 120 tttactttgt gcacctgaac actgcacacc gagggcgacc accgcccccg agatgcccag 180 cttctattct agagcgccgc gccggcgccg aatgggttaa cgggcggggg gacacgcctc 240 cgtgcgcttg cgcggcgtcc cttcgccccg ccttcgcagc gcagtcacat gacccgccca 300 accggcgtcc gcctataaaa agctgagtgt tgacgtcagc gtt 343 <210> 511 <211> 329 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 511 cggtccgaat ttcaaagtct ttttcctatt gacctacaag gttttcaaga atcatgttgt 60 aagcaactgt gttctgagga atctatgttt aaaaacccat ccgtggatct tggcccaggg 120 tccagagact gagctagcca cgccccggcc gcgccgcagc cactcccacg gcagttcaag 180 tgttaagtcc caaagaccgc gctctgtgca tgcgcagacc cgtccacagc tggctcctag 240 ccaacccggc cggacgagca cccggcgccg tcacgtgacg cacccaaccg gcgtcgacct 300 ataaaaggcc gggcgttgac gtcagcggt 329 <210> 512 <211> 329 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 512 cggtccgaat ttcaaagtct ttttcctatt gacctacaag gttttcaaga atcatgttgt 60 aagcaactgt gttctgagga atctatgttt aaaaacccat ccgtggatct tggcccaggg 120 tccagagact gagctagcca cgccccggcc gcgccgcagc cactcccacg gcagttcaag 180 tgttaagtcc caaagaccgc gctctgtgca tgcgcagacc cgtccacagc tggctcctag 240 ccaacccggc cggacgagca cccggcgccg tcacgtgacg cacccaaccg gcgtcgacct 300 ataaaaggcc gggcgttgac gtcagcgtt 329 <210> 513 <211> 325 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 513 gggtccgaat ttcaaagtcc tttttattga cttacaaggt tttcaaggaa aatcttggaa 60 gtaactgtgt tccgaagaat ctacgtttaa aaaccgaccc ctggatcttt gccttgggtc 120 caaggaccga gctggccacg ccccagccgc gccgcagcca ctcccaaggc agttcaagtg 180 ttaagcccga aaggtagagc tctgcgcatg tgcacacccg tccatagctg ggtcccagcc 240 aaccaggccg gaggagcacc cgcgccgtca cgtgacgtgc ccaaccggcg tcgacctata 300 aaaggccggg cgttgacgtc agcgg 325 <210> 514 <211> 326 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 514 gggtccgaat ttcaaagtcc tttttattga cttacaaggt tttcaaggaa aatcttggaa 60 gtaactgtgt tccgaagaat ctacgtttaa aaaccgaccc ctggatcttt gccttgggtc 120 caaggaccga gctggccacg ccccagccgc gccgcagcca ctcccaaggc agttcaagtg 180 ttaagcccga aaggtagagc tctgcgcatg tgcacacccg tccatagctg ggtcccagcc 240 aaccaggccg gaggagcacc cgcgccgtca cgtgacgtgc ccaaccggcg tcgacctata 300 aaaggccggg cgttgacgtc agcgtt 326 <210> 515 <211> 169 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 515 ttcgccccgc cttcgcagcg cagtcacatg acccgcccaa ccggcgtccg cctataaaaa 60 gctgagtgtt gacgtcagcg ttctcttccg ccgtcgtcgc cgccatcctc ggcgcgactc 120 gcttctttcg gttctacctg ggagaatcca ccgccatccg ccaccacca 169 <210> 516 <211> 163 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 516 agcccagggt gcgcgcgcgc cgtcacgtga cacgcccaac cggcgtcgcc gtataaaagc 60 gcgggcgttg acgtcagcgt tctcttccgc cgcagccgcc gccatcgtcg gcgcccctcg 120 cacttctcct gtgcccgtga gaatccgtcg ccatccgcca cca 163 <210> 517 <211> 164 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 517 ggccggacga gcacccggcg ccgtcacgtg acgcacccaa ccggcgtcga cctataaaag 60 gccgggcgtt gacgtcagcg ttctcttccg ccgcagccgc cgccatcgtc ggcgcgcttc 120 cctgttcacc tctgactctg agaatccgtc gccatccgcc acca 164 <210> 518 <211> 280 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 518 tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc 60 caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg 120 gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag gcggagaggt 180 gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg 240 cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg 280 <210> 519 <211> 282 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 519 tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc 60 caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg 120 gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag 180 gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc 240 ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gg 282 <210> 520 <211> 280 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 520 tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc 60 caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg 120 gggcgcgcgc caggtggggc ggggcggggc gaggggcggg gcggggcgag gcggagaggt 180 gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc gaggcggcgg 240 cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg 280 <210> 521 <211> 283 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 521 tgggtcgagg tgagccccac gttctgcttc actctcccca tctccccccc ctccccaccc 60 ccaattttgt atttatttat tttttaatta ttttgtgcag cgatgggggc gggggggggg 120 ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg 180 tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg 240 gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg gga 283 <210> 522 <211> 270 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 522 tctctctttt tttttttttt tttttttttt tttccaaaag gaggggagag ggggtaaaaa 60 aatgctgcac tgtgcggcta ggccggtgag tgagcggcgc ggagccaatc agcgctcgcc 120 gttccgaaag ttgcctttta tggctcgagt ggccgctgtg gcgtcctata aaacccggcg 180 gcgcaacgcg cagccactgt cgagtccgcg tccacccgcg agcacaggcc tttcgcagct 240 ctttcttcgc cgctccacac ccgccaccag 270 <210> 523 <211> 294 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 523 tcaatctcgc tttctctctc gctttttttt tttttcttct tctttttttt tttttttttc 60 aaaaggaggg gagagggggt aaaaaaatgc tgcactgtgc ggcgaggccg gtgagtgagc 120 gacgcggagc caatcagcgc ccgccgttcc gaaagttgcc ttttatggct cgagtggccg 180 ctgtggcgtc ctataaaacc cggcggcgca acgcgcagcc actgtcgagt cgcgtccacc 240 cgcgagcaca gcttctttgc agctccttcg ttgccggtcc acacccgcca ccag 294 <210> 524 <211> 230 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 524 tcaatctcgc tttctctctc gctttttttt ttttcttctt cttttttttt ttttttttca 60 aaaggagggg agagggggta aaaaaatgct gcactgtgcg gcgaggccgg tgagtgagcg 120 acgcggagcc aatcagcgcc cgccgttccg aaagttgcct tttatggctc gagtggccgc 180 tgtggcgtcc tataaaaccc ggcggcgcaa cgcgcagcca ctgtcgagtc 230 <210> 525 <211> 308 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 525 acctcttcct caactcactt ctctctactc tcactttttt ttttcttctt cttttttttt 60 tttttttttt tttttttttt tgcaaaagaa gggggtaaaa aaatgctgca ctgtcgggcg 120 aggccggtga gtgagcgagc cggagccaat cagcgcccgc cgttccgaaa ttgcctttta 180 tggctcgagt ggccgctgtg gcgtcctata aaacccggcg gcgcaacgcg cgccactgtc 240 gagtccgcgt ccacccgcga gtacaacctc cttgcagctc ctccgtcccg gtccacaccc 300 gccaccag 308 <210> 526 <211> 253 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 526 gcccagcacc ccaaggcggc caacgccaaa actctccctc ctcctcttcc tcaatctcgc 60 tctcgctctt tttttttttc gcaaaaggag gggagagggg gtaaaaaaat gctgcactgt 120 gcggcgaagc cggtgagtga gcggcgcggg gccaatcagc gtgcgccgtt ccgaaagttg 180 ccttttatgg ctcgagcggc cgcggcggcg ccctataaaa cccagcggcg cgacgcgcca 240 ccaccgccga gtc 253 <210> 527 <211> 61 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 527 ttgcctttta tggctcgagt ggccgctgtg gcgtcctata aaacccggcg gcgcaacgcg 60 c 61 <210> 528 <211> 494 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 528 atgacgtcga ggagaagttc cccaactttc ccgcctctca gcctttgaaa gaaagaaagg 60 ggagggggca ggccgcgtgc agccgcgagc ggtgctgggc tccggctcca attccccatc 120 tcagtcgttc ccaaagtcct cctgtttcat ccaagcgtgt aagggtcccc gtccttgact 180 ccctagtgtc ctgctgccca cagtccagtc ctgggaacca gcaccgatca cctcccatcg 240 ggccaatctc agtcccttcc cccctacgtc ggggcccaca cgctcggtgc gtgcccagtt 300 gaaccaggcg gctgcggaaa aaaaaaagcg gggagaaagt agggcccggc tactagcggt 360 tttacgggcg cacgtagctc aggcctcaag accttgggct gggactggct gagcctggcg 420 ggaggcgggg tccgagtcac cgcctgccgc cgcgcccccg gtttctataa attgagcccg 480 cagcctcccg cttc 494 <210> 529 <211> 486 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 529 tttttgtaga aatgtcttgg tgtcctcgtc caatcaggta gccatctctg aaatatctgg 60 ctccgttgca actccgaacg acctgctggc aacgtaaaat tctccggggt aaaacttaaa 120 tgtggagtaa tggaaccaga aacatctctt cccttctctc tccttccacc gcccgttacc 180 gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgca 240 cttcccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg 300 atggaaaagt cccggccgtc gctggcaata atagcgggcg gacgcatgtc atgagattat 360 tggaaaccac cagaatcgaa tataaaaggc gaacaccttt cccaattttg gtttctcctg 420 acccaaagac tttaaattta atttatttgt ccctatttca atcaattgaa caactatcaa 480 aacaca 486 <210> 530 <211> 486 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 530 tttttgtaga aatgtcttgg tgtcctcgtc caatcaggta gccatctctg aaatatctgg 60 ctccgttgca actccgaacg acctgctggc aacgtaaaat tctccggggt aaaacttaaa 120 tgtggagtaa tggaaccaga aacgtctctt cccttctctc tccttccacc gcccgttacc 180 gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgct 240 cttcccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg 300 atggaaaagt cccggccgtc gctggcaata atagcgggcg gacgcatgtc atgagattat 360 tggaaaccac cagaatcgaa tataaaaggc gaacaccttt cccaattttg gtttctcctg 420 acccaaagac tttaaattta atttatttgt ccctatttca atcaattgaa caactatcaa 480 aacaca 486 <210> 531 <211> 486 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 531 tttttgtaga aatgtcttgg tgtcctcgtc caatcaggta gccatctctg aaatatctgg 60 ctccgttgca actccgaacg acctgctggc aacgtaaaat tctccggggt aaaacttaaa 120 tgtggagtaa tggaaccaga aacgtctctt cccttctctc tccttccacc gcccgttacc 180 gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgct 240 ctacccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg 300 atggaaaagt cccggccgtc gctggcaata atagcgggcg gacgcatgtc atgagattat 360 tggaaaccac cagaatcgaa tataaaaggc gaacaccttt cccaattttg gtttctcctg 420 acccaaagac tttaaattta atttatttgt ccctatttca atcaattgaa caactatcaa 480 aacaca 486 <210> 532 <211> 843 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 532 taccaaaaaa cctggagaag ttcctcagct tgcccgcctc ccagcctttg aaagaatagg 60 ggaagggggt ggcgcgtgct gtccccaggc gaccgggctc aggctccgac tccccatgcc 120 agccgctccc gggtcgtccg tgcggcccct tggcgcggcc tgggctcctg gacctctctg 180 gttcccacca ggatccccat ccccgagtct atagtggctt gcgtgcccat agtcccgtcc 240 cgggaacctt tagccatcac tgcccccgcg ggccacctcg gtcccctccc cctctcaggc 300 ctgggcccac atgcctggtg cgtgcactgg ggaacaaggc gggcccgcaa aaagaaaaac 360 gaggaggccc ggctactcgc gggtttacgg gcgcacgtag ctcaggcctc ctcgcccttg 420 ggctgggact gggcgagcag cacgggaggc ggggcgcacg tcacccacgc cccgccgccc 480 ccagtcccta taaattgagg ctgcgggttc ctccggtgct ctctgctccg ccccgttcga 540 caggcagccg cttcttctcg tgcagtgcta ggtgaccaag gcagaggccg tgggggcttg 600 ggggccggcg ggaggagggg gcgtgctggc cggggcttgg gcagccccga ggcggtgctg 660 ggcccccaga gcggagccgc cgggcggggt cccgcattgc aggggcgagc agagtacgtg 720 ccgtgccctg gggtgggaat ggaggccggg gggaggggcg ccgagggctc tggccgctgg 780 gctttgccga ctgccctgat gctcactctc ctctccccac agcgcgtccc cgagactgcc 840 acc 843 <210> 533 <211> 799 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 533 atcctcaact tttccacagc ctttgcataa aggggagagg gtcggcggtg cagctgtggc 60 acacacgcac ttctgctcaa cccgcccccc cccgcccccg ttcctgttcc ttcccaggtt 120 ctccccattt tatcggggcg gcaactttta ggtccctggg tcctggaagt ccttagtaca 180 cactcttcgt ccttaagtcc atagtctgta ttccctcggt cctatcctgt cccccatcac 240 cgggtcacct ccccagcgaa gcaatctcag ttcccctccc cctctcagcc ccgagcccac 300 acgtttggtg cgtgcacatt tcaaaaacga ggcgggtcca aagagagggg gtggggaggt 360 gccgagtggc ccagctactc gcggctttac gggtgcacgt agctcaggcc tcagcgccct 420 tgagctgtga ctggatggat gagcggggcg ggaggcgggg cgagcgtcct cggcgctccc 480 caccacccca gttcctataa atacggactg cagccctccc cggtgctctc tgctcctccc 540 tgttctagag acagccgcat ctttccgtgc agtgccaggt gaaaaccgca gagtgggccg 600 caggtggccg gggacggtcg gaaacgggga aggggggcgc tcagcccggg actgcgggcg 660 ctggggcgag ctccactgcc cgagcccggg ctccgcattg cagaggctgg agggggaagg 720 gatggggggc gcggcggggg gcacgctgac ctctctttct tctctctccc tccgcagcct 780 cgctccggag actgccacc 799 <210> 534 <211> 163 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 534 ggagacgcct tgggctggga ctggctgagc ctggcgggag gcggggtccg agtcaccgcc 60 tgccgccgcg cccccggttt ctataaattg agcccgcagc ctcccgcttc gctctctgct 120 cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc cag 163 <210> 535 <211> 185 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 535 ggagacggca cgtagctcag gcctcaagac cttgggctgg gactggctga gcctggcggg 60 aggcggggtc cgagtcaccg cctgccgccg cgcccccggt ttctataaat tgagcccgca 120 gcctcccgct tcgctctctg ctcctcctgt tcgacagtca gccgcatctt cttttgcgtc 180 gccag 185 <210> 536 <211> 224 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 536 ggagacgggg agaaagtagg gcccggctac tagcggtttt acgggcgcac gtagctcagg 60 cctcaagacc ttgggctggg actggctgag cctggcggga ggcggggtcc gagtcaccgc 120 ctgccgccgc gcccccggtt tctataaatt gagcccgcag cctcccgctt cgctctctgc 180 tcctcctgtt cgacagtcag ccgcatcttc ttttgcgtcg ccag 224 <210> 537 <211> 275 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 537 ggagacgacg ctcggtgcgt gcccagttga accaggcggc tgcggaaaaa aaaaagcggg 60 gagaaagtag ggcccggcta ctagcggttt tacgggcgca cgtagctcag gcctcaagac 120 cttgggctgg gactggctga gcctggcggg aggcggggtc cgagtcaccg cctgccgccg 180 cgcccccggt ttctataaat tgagcccgca gcctcccgct tcgctctctg ctcctcctgt 240 tcgacagtca gccgcatctt cttttgcgtc gccag 275 <210> 538 <211> 122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 538 ggagacgcga gtcaccgcct gccgccgcgc ccccggtttc tataaattga gcccgcagcc 60 tcccgcttcg ctctctgctc ctcctgttcg acagtcagcc gcatcttctt ttgcgtcgcc 120 ag 122 <210> 539 <211> 167 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 539 ggagacgcag ctccccccac catccagttc ctataaatac ggactgcagc cctccctggt 60 gctctctgct cctccctgtt ctagagacag ccgcatcttc ttgtgcagtg ccaggctctc 120 tgctcctcct gttcgacagt cagccgcatc ttcttttgcg tcgccag 167 <210> 540 <211> 190 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 540 ggagacggcg ggaggcgggg cgcgcgtcat cagctccccc caccatccag ttcctataaa 60 tacggactgc agccctccct ggtgctctct gctcctccct gttctagaga cagccgcatc 120 ttcttgtgca gtgccaggct ctctgctcct cctgttcgac agtcagccgc atcttctttt 180 gcgtcgccag 190 <210> 541 <211> 211 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 541 ggagacgagc tgggactgga tgagccgagc gggaggcggg gcgcgcgtca tcagctcccc 60 ccaccatcca gttcctataa atacggactg cagccctccc tggtgctctc tgctcctccc 120 tgttctagag acagccgcat cttcttgtgc agtgccaggc tctctgctcc tcctgttcga 180 cagtcagccg catcttcttt tgcgtcgcca g 211 <210> 542 <211> 239 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 542 ggagacggca cgtagctcag gcctctgcgc ccttgagctg ggactggatg agccgagcgg 60 gaggcggggc gcgcgtcatc agctcccccc accatccagt tcctataaat acggactgca 120 gccctccctg gtgctctctg ctcctccctg ttctagagac agccgcatct tcttgtgcag 180 tgccaggctc tctgctcctc ctgttcgaca gtcagccgca tcttcttttg cgtcgccag 239 <210> 543 <211> 278 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 543 ggagacgggg aatgagagag gcccagctac tcgcggcttt acgggtgcac gtagctcagg 60 cctctgcgcc cttgagctgg gactggatga gccgagcggg aggcggggcg cgcgtcatca 120 gctcccccca ccatccagtt cctataaata cggactgcag ccctccctgg tgctctctgc 180 tcctccctgt tctagagaca gccgcatctt cttgtgcagt gccaggctct ctgctcctcc 240 tgttcgacag tcagccgcat cttcttttgc gtcgccag 278 <210> 544 <211> 413 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 544 ggagacgtcc tatcctggga accctcatcc ggtcacttcc tcggcgggac aatctcagct 60 cccctccccc tctcaggtcg gagcccacac gcttggtgcg tgcacatttc aaaaacgagg 120 cgggtccaaa aagagggagg gggggaatga gagaggccca gctactcgcg gctttacggg 180 tgcacgtagc tcaggcctct gcgcccttga gctgggactg gatgagccga gcgggaggcg 240 gggcgcgcgt catcagctcc ccccaccatc cagttcctat aaatacggac tgcagccctc 300 cctggtgctc tctgctcctc cctgttctag agacagccgc atcttcttgt gcagtgccag 360 gctctctgct cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc cag 413 <210> 545 <211> 508 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 545 tctaccgggt aggggaggcg cttttcccaa ggcagtctgg agcatgcgct ttagcagccc 60 cgctgggcac ttggcgctac acaagtggcc tctggcctcg cacacattcc acatccaccg 120 gtaggcgcca accggctccg ttctttggtg gccccttcgc gccaccttct actcctcccc 180 tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg caggacgtga caaatggaag 240 tagcacgact cactagtctc gtgcagatgg acagcaccgc tgagcaatgg aagcgggtag 300 gcctttgggg cagcggccaa tagcagcttt gctccttcgc tttctgggct cagaggctgg 360 gaaggggtgg gtccgggggc gggctcaggg gcgggctcag gggcggggcg ggcgcccgaa 420 ggtcctccgg aggcccggca ttctgcacgc ttcaaaagcg cacgtctgcc gcgctgttct 480 cctcttcctc atctccgggc ctttcgtc 508 <210> 546 <211> 460 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 546 ctaccgggta ggggaggcgc ttttcccaag gcagtctgga gcatgcgctt tagcagcccc 60 gctgggcact tggcgctaca caagtggcct ctggcctcgc acacattcca catccaccgg 120 taggcgccaa ccggctccgt tctttggtgg ccccttcgcg ccaccttcta ctcctcccct 180 agtcaggaag ttcccccccg ccccgcagct cgcgtcgtgc aggacgtgac aaatggaagt 240 agcacgactc actagtctcg tgcagatgga cagcaccgct gagcaatgga agcgggtagg 300 cctttggggc agcggccaat agcagctttg ctccttcgct ttctgggctc aggggcgggg 360 cgggcgcccg aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg 420 ccgcgctgtt ctcctcttcc tcatctccgg gcctttcgtc 460 <210> 547 <211> 466 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 547 cggggttggg gttgcgcctt ttccaaggca gccctgggtt tgcgcaggga cgcggctgct 60 ctgggcgtgg ttccgggaaa cgcagcggcg ccgaccctgg gcctcgcaca ttcttcacgt 120 ccgttcgcag cgtcacccgg atcttcgccg ctacccttgt gggccccccg gcgacgcttc 180 ctcgtccgcc cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa 240 cggaagccgc acgtctcact agtaccctcg cagacggaca gcgccaggga gcaatggcag 300 cgcgccgacc gcgatgggct gtggccaata gcggctgctc agcagggcgc gccgagagca 360 gcggccggga aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc 420 tgcccgcgcg gtgttccgca ttctgcaagc ctccggagcg cacgtc 466 <210> 548 <211> 458 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 548 tctaccgggt aggggaggcg cttttcccaa ggcagtctgg agcatgcgct ttagcagccc 60 cgctgggcac ttggcgctac acaagtggcc tctggcctcg cacacattcc acatccaccg 120 gtaggcgcca accggctccg ttctttggtg gccccttcgc gccaccttct actcctcccc 180 tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg caggacgtga caaatggaag 240 tagcacgact cactagtctc gtgcagatgg acagcaccgc tgagcaatgg aagcgggtag 300 gcctttgggg cagcggccaa tagcagcttt gctccttcgc tttctgagag cagcggccgg 360 gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt gggccctgtt cctgcccgcg 420 cggtgttccg cattctgcaa gcctccggag cgcacgtc 458 <210> 549 <211> 523 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 549 cacgggtggg ggtgagcgct tttcctaagg cagcctagga ctaaagcagc gccacagata 60 ctttgggtgt ggctcctgaa ccgcggctgc agaagctacg ggcctctcaa actttccacg 120 tccaagtcgt agcacgacgc agctcccttc cgccccacct gcaggtcgct cgatgccgcc 180 tctcgctccg cccctagtca ggaaggttcc cccgcagctc gcagcgtgcc ggacgtgaca 240 aatggaagcc gcacgtccca ccagtaccct cgcagacgga cagcgccttg gagcaatggc 300 agcgagccgg cccctttggg ccagggccaa tagcggccgc tctgcttggc gcgccctgag 360 ccgcggccgg gaaggggcgg tgcgggaggc ggggcgtcgg ggggcggtgc gggcgcgctc 420 ccggtgggcg aggtgctcag cattctgcac gcgtctggac agcgcgtcgg tcgcattatc 480 cttctctcag tctccaacct ctcgccctcg ccttattgcc acc 523 <210> 550 <211> 527 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 550 cacggggttg gggttgcgcc ttttccaagg cagccctggg tttgcgcagg gatgcggctg 60 ctctgggcgt ggttccggga aacgcagcgg cgccgacctt gggtcttgca cattcttcac 120 gtccgttcgc agcgtcaccc ggatcttcgc cgctaccctt gtgggccccc cggcgacgct 180 tcctgctccg cccctaagtc gggaaggttc cttgcggttc gcggcgtgcc ggacgtgaca 240 aacggaagcc gcacctctca ctagtaccct cgcagacgga cagcgccaag gagcaatggc 300 agcgcgccga ccgcgatggg ctgtggccaa tagcggctgc tcagcagggc gcgccgggag 360 cagcggccgg gaaggggcgg tgcgggaggc ggggtgtggg gcggtagtgt ggcccctgtt 420 cctgcccgcg cggtgttcgg cattctgcaa gcctccggag cggacgtcag cagtcggctc 480 cctcgttgac cgaatcaccg acctctctcc ccagctgtat tgccacc 527 <210> 551 <211> 660 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 551 tctaccgggt aggggaggcg cttttcccaa ggcagtctgg agcatgcgct ttagcagccc 60 cgctgggcac ttggcgctac acaagtggcc tctggcctcg cacacattcc acatccaccg 120 gtaggcgcca accggctccg ttctttggtg gccccttcgc gccaccttct actcctcccc 180 tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg caggacgtga caaatggaag 240 tagcacgact cactagtctc gtgcagatgg acagcaccgc tgagcaatgg aagcgggtag 300 gcctttgggg cagcggccaa tagcagcttt gctccttcgc tttctgggct caggggcggg 360 gcgggcgccc gaaggtcctc cggaggcccg gcattctgca cgcttcaaaa gcgcacgtct 420 gccgcgctgt tctcctcttc ctcatctccg ggcctttcgt caagcttgga cacaagacag 480 gcttgcgaga tatgtttgag aataccactt tatcccgcgt cagggagagg cagtgcgtaa 540 aaagacgcgg actcatgtga aatactggtt tttagtgcgc cagatctcta taatctcgcg 600 caacctattt tcccctcgaa cactttttaa gccgtagata aacaggctgg gacacttcac 660 <210> 552 <211> 1092 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 552 aagtttccag agctttcgag gaaggtttct tcaactcaaa ttcatccgcc tgataatttt 60 cttatatttt cctaaagaag gaagagaagc gcatagagga gaagggaaat aattttttag 120 gagcctttct tacggctatg aggaatttgg ggctcagttg aaaagcctaa actgcctctc 180 gggaggttgg gcgcggcgaa ctactttcag cggcgcacgc agacggcgtc tacgtgaggg 240 gtgataagtg acgcaacact cgttgcataa atttgcgctc cgccagcccg gagcatttag 300 gggcggttgg ctttgttggg tgagcttgtt tgtgtccctg tgggtggacg tggttggtga 360 ttggcaggat cctggtatcc gctacaggta ctggcccaca gccgtaaaga gctgcggggg 420 cgtgagaggg gggaatgggt gaggtcaagc tggaggcttc ttggggttgg gtgggccgct 480 gaggggaggg gagggcgagg tgacgcgaca cccggccttt ctgggagagt gggccttgtt 540 gacctaaggg gggcgagggc agttggcacg cgcacgcgcc gacagaaact aacagacatt 600 aaccaacagc gattccgtcg cgtttacttg ggaggaaggc ggaaaagagg tagtttgtgt 660 ggcttctgga aaccctaaat ttggaatccc agtatgagaa tggtgtccct tcttgtgttt 720 caatgggatt tttacttcgc gagtcttgtg ggtttggttt tgttttcagt ttgcctaaca 780 ccgtgcttag gtttgaggca gattggagtt cggtcggggg agtttgaata tccggaacag 840 ttagtgggga aagctgtgga cgcttggtaa gagagcgctc tggattttcc gctgttgacg 900 ttgaaacctt gaatgacgaa tttcgtatta agtgacttag ccttgtaaaa ttgaggggag 960 gcttgcggaa tattaacgta tttaaggcat tttgaaggaa tagttgctaa ttttgaagaa 1020 tattaggtgt aaaagcaaga aatacaatga tcctgaggtg acacgcttat gttttacttt 1080 taaactaggt ca 1092 <210> 553 <211> 215 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 553 cagctgcttc atccccgtgg cccgttgctc gcgtttgctg gcggtgtccc cggaagaaat 60 atatttgcat gtctttagtt ctatgatgac acaaaccccg cccagcgtct tgtcattggc 120 gaaaacacgc agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg 180 acgcgtgtgg cctcgaacac agagcgactc tgcag 215 <210> 554 <211> 753 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 554 aaatgagtct tcggacctcg cgggggccgc ttaagcggtg gttagggttt gtctgacgcg 60 gggggagggg gaaggaacga aacactctca ttcggaggcg gctcggggtt tggtcttggt 120 ggccacgggc acgcagaaga gcgccgcgat cctcttaagc acccccccgc cctccgtgga 180 ggcgggggtt tggtcggcgg gtggtaactg gcgggccgct gactcgggcg ggtcgcgcgc 240 cccagagtgt gaccttttcg gtctgctcgc agacccccgg gcggcgccgc cgcggcggcg 300 acgggctcgc tgggtcctag gctccatggg gaccgtatac gtggacaggc tctggagcat 360 ccgcacgact gcggtgatat taccggagac cttctgcggg acgagccggg tcacgcggct 420 gacgcggagc gtccgttggg cgacaaacac caggacgggg cacaggtaca ctatcttgtc 480 acccggaggc gcgagggact gcaggagctt cagggagtgg cgcagctgct tcatccccgt 540 ggcccgttgc tcgcgtttgc tggcggtgtc cccggaagaa atatatttgc atgtctttag 600 ttctatgatg acacaaaccc cgcccagcgt cttgtcattg gcgaattcga acacgcagat 660 gcagtcgggg cggcgcggtc ccaggtccac ttcgcatatt aaggtgacgc gtgtggcctc 720 gaacaccgag cgaccctgca gcgacccgct taa 753 <210> 555 <211> 270 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 555 cagtgtggtt ttcaagagga agcaaaaagc ctctccaccc aggcctggaa tgtttccacc 60 caatgtcgag cagtgtggtt ttgcaagagg aagcaaaaag cctctccacc caggcctgga 120 atgtttccac ccaatgtcga gcaaaccccg cccagcgtct tgtcattggc gaattcgaac 180 acgcagatgc agtcggggcg gcgcggtccc aggtccactt cgcatattaa ggtgacgcgt 240 gtggcctcga acaccgagcg accctgcagg 270 <210> 556 <211> 149 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 556 tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt 60 ttatttatgc agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag 120 gcttttttgg aggtataggc ttttgcaaa 149 <210> 557 <211> 128 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 557 gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg 60 ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct 120 tttgcaaa 128 <210> 558 <211> 408 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 558 cagctgcttc atccccgtgg cccgttgctc gcgtttgctg gcggtgtccc cggaagaaat 60 atatttgcat gtctttagtt ctatgatgac acaaaccccg cccagcgtct tgtcattggc 120 gaaaacacgc agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg 180 acgcgtgtgg cctcgaacac agagcgactc tgcagggaca caagacaggc ttgcgagata 240 tgtttgagaa taccacttta tcccgcgtca gggagaggca gtgcgtaaaa agacgcggac 300 tcatgtgaaa tactggtttt tagtgcgcca gatctctata atctcgcgca acctattttc 360 ccctcgaaca ctttttaagc cgtagataaa caggctggga cacttcac 408 <210> 559 <211> 193 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 559 ggacacaaga caggcttgcg agatatgttt gagaatacca ctttatcccg cgtcagggag 60 aggcagtgcg taaaaagacg cggactcatg tgaaatactg gtttttagtg cgccagatct 120 ctataatctc gcgcaaccta ttttcccctc gaacactttt taagccgtag ataaacaggc 180 tgggacactt cac 193 <210> 560 <211> 318 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 560 ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca 60 aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac 120 tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa 180 ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg 240 gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt 300 gagagggcgg atggtcga 318 <210> 561 <211> 827 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 561 gtaagtaccg cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact 60 gtttttggct tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt 120 agcctatagg tgtgggttat tgaccattat tgaccactcc cctattggtg acgatacttt 180 ccattactaa tccataacat ggctctttgc cacaactctc tttattggct atatgccaat 240 acactgtcct tcagagactg acacggactc tgtattttta caggatgggg tctcatttat 300 tatttacaaa ttcacatata caacaccacc gtccccagtg cccgcagttt ttattaaaca 360 taacgtggga tctccacgcg aatctcgggt acgtgttccg gacatgggct cttctccggt 420 agcggcggag cttctacatc cgagccctgc tcccatgcct ccagcgactc atggtcgctc 480 ggcagctcct tgctcctaac agtggaggcc agacttaggc acagcacgat gcccaccacc 540 accagtgtgc cgcacaaggc cgtggcggta gggtatgtgt ctgaaaatga gctcggggag 600 cgggcttgca ccgctgacgc atttggaaga cttaaggcag cggcagaaga agatgcaggc 660 agctgagttg ttgtgttctg ataagagtca gaggtaactc ccgttgcggt gctgttaacg 720 gtggagggca gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat 780 agctgacaga ctaacagact gttcctttcc atgggtcttt tctgcag 827 <210> 562 <211> 827 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 562 gtaagtaccg cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact 60 gtttttggct tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt 120 agcctatagg tgtgggttat tgaccattat tgaccactcc cctattggtg acgatacttt 180 ccattactaa tccataacat ggctctttgc cacaactctc tttattggct atatgccaat 240 acactgtcct tcagagactg acacggactc tgtattttta caggatgggt tctcatttat 300 tatttacaaa ttcacatata caacaccacc gtccccagtg cccgcagttt ttattaaaca 360 taacgtggga tctccacgcg aatctcgggt acgtgttccg gacatgggtt cttctccggt 420 agcggcggag cttctacatc cgagccctgc tcccatgcct ccagcgactc atggtcgctc 480 ggcagctcct tgctcctaac agtggaggcc agacttaggc acagcacgat gcccaccacc 540 accagtgtgc cgcacaaggc cgtggcggta gggtatgtgt ctgaaaatga gctcggggag 600 cgggcttgca ccgctgacgc atttgaaaga cttaaggcag cggcagaaga agatgcaggc 660 agctgagttg ttgtgttctg ataagagtca gaggtaactc ccgttgcggt gctgttaacg 720 gtggagggca gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat 780 agctgacaga ctaacagact gttcctttcc atgggtcttt tctgcag 827 <210> 563 <211> 825 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 563 gtaagtagac caaggccttt tattggctgc ggtgttaagg caagctgcct gtctatccct 60 atctatctac tatccacctg gctctctagc tccatactgc gtacggtgtt tgttagctta 120 gggtgatagc aagtagaacg ctggtgatgg ttgctctcta tcagtttagc gctggtgatg 180 gtggcctcct tctccatttc ttatatatat atgctggtga tggtccctct tccatggccg 240 cggtgtgctt cggtgccggg taccgtaacg tggtacagaa aaaggcctga cacgtacgcg 300 tctctcccta ggatgctatg tgtctgtagc accggcggag cttgcgagct cgatgtccaa 360 gatagagtct ccatgactgc tcagatcgtc tcctgtgttc acacaccaga tattacaagc 420 gacggccgcc atgataagtc caaaaatgag cagaatacag aatattgtac tcagaggctg 480 cagccatctt ggtggcctgc tgtggtgctc ttttcccgtg gaggactccg tcagttcctg 540 cgtgttgttg ctcgtactgc gaagatctct cttgccccgt cctgaaaacc taggccctga 600 cagaaaaaag ggagagttag gagagggcac agaggattct gtctgtgtca agggggcttc 660 catgttgttt ctttacctga gatctcttcc accagttgtt ttttatcagc aactgacagg 720 tagtatatca aaatgagtgc actgatgatt attagcactg tatactttag atatcttctg 780 gtctctgtgg acatctgttg atgataaaaa attatatttt tttag 825 <210> 564 <211> 1246 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 564 gtaaggttgc attgggctcg gctatgggac ggggatttgg cccggtactt taatatgggt 60 ggggtcttat gggtaggggg cttattaata taacgccccc tacccataca tattgcgtca 120 cgtaattaga agccccctac cacgccattg gcgcccgccc atagcggtac tttcggttct 180 atacaagatg gctaccgcgg ttttcgatcg ctcccggggg tctcatttct atagctggaa 240 agcatccgac ccccatgatc tgtgccttag accccagggt acgtgcctgg ataggtgggc 300 gacccctagc ggctgcttgt atttttatat cagagatcga aaatcacagc cgcccgtaac 360 agctgtcagg gctatacaag atggcgaccg ctactttcga tcgctttttc ttccctcgat 420 cctgcttccg aaacgcaacc cacccccggg gtatgtgcct tagaccctat agatgccccc 480 caggacgcag gaaaaatttt agctcccctc tataatttta ttcgagcgat cgaaatccgc 540 ggaccgcccg ggtttttact ttcgttttct cggtcgccgc tcggctcgga ttccgagcag 600 aaaaagggct agaaagctgc gctcacctgc cgaaacgcgt tgttcggatc atcccgggag 660 ggccagcgta gtctccgttg ctgggttcgg ccgagggatc gagtcgagcg ggcggcggga 720 cgccgggaac gagagaggat cgggagcggg cgcccgggtg gctcgggagc ggccgggaga 780 cggtctgcag agctccagag ctgcgtgtcc tgacactgaa cagttgggaa aaatactgga 840 tcttataatg acccagggga aggggtccga gatcctccca gtgtccgaga ctgccaagag 900 acactcctgt tgaaaagcag ctctaaaacg ttttcctgct catctctgcc agacccccgc 960 ccactgacag agctcaattg atagcagatg tcctctttgg aaggacacac gcttccacaa 1020 acaccgttcc tcactgaggt gcattgtctg ggagggaagg tcaccttctt gttcattgtg 1080 gacggtgtgc ggcccaggcc tcggacgacc ctggcccggg cttccttctt cctgatccag 1140 gtagattgac gtgcggacat cgcgaacgac cgcagtcttc ctgatctttg aatgactcga 1200 gtacatgagc gcacctttcg agactgatct ctcttgttct ccatag 1246 <210> 565 <211> 1246 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 565 gtaaggttgc attgggctcg gctatgggac ggggatttgg cccggtactt taatatgggt 60 ggggtcttat gggtaggggg cttattaata taacgccccc tacccataca tattgcgtca 120 cgtaattaga agccccctac cacgccattg gcgcccgccc atagcggtac tttcggttct 180 atacaagatg gctaccgcgg ttttcgatcg ctcccggggg tcacatttct atagctggaa 240 agcatccgac ccccatgatc tgtgccttag accccagggt acgtgcctgg ataggtgggc 300 gacccctagc ggctgcttgt atttttatat cagagatcga aaatcacagc cgcccgtaac 360 agctgtcagg gctatacaag atggcgaccg ctactttcga tcgctttttc ttccctcgat 420 cctgcttccg aaacgcaacc cacccccggg gtatgtgcct tagaccctat agatgccccc 480 caggacgcag gaaaaatttt agctcccctc tataatttta ttcgagcgat cgaaatccgc 540 ggaccgcccg ggtttttact ttcgttttct cggtcgccgc tcggctcgga ttccgagcag 600 aaaaagggct agaaagctgc gctctcctgc cgaaacgcgt tgttcggatc atcccgggag 660 ggccagcgta gtctccgttg ctgggttcgg ccgagggatc gagtcgagcg ggcggcggga 720 cgccgggaac gagagaggat cgggagcggg cgcccgggtg gctcgggagc ggccgggaga 780 gggtctgcag agctccagag ctgcgtgtcc tgacactgaa cagttgggaa aaatactgga 840 tcttataatg acccagggga aggggtccga gatcctccca gtgtccgaga ctgccaagag 900 acactcctgt tgaaaagcag ctctaaaacg ttttcctgct catctctgcc agacccccgc 960 ccactgacag agctcaattg atagcagatg tcctctttgg aaggacacac gcttccacaa 1020 acaccgttcc tcactgaggt gcattgtctg ggagggaagg tcaccttctt gttcattgtg 1080 gacggtgtgc ggcccaggcc tcggacgacc ctggcccggg cttccttctt cctgatccag 1140 gtagattgac gtgcggacat cgcgaacgac cgcagtgttc ctgatctttg aatgactcga 1200 gtacatgagc gcacctttcg agactgatct ctcttgttct ccatag 1246 <210> 566 <211> 114 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 566 gtacgtgtcg gggtttgtgc cccccctttt tttttaataa aattgtatta atgttatata 60 catatctcct gtatgtgacc catgtgctta tgactctatt tctcatgtgt ttag 114 <210> 567 <211> 170 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 567 gtaagtctgt tgacatgtat gtgatgtata ctaacctgca tgggacgtgg atttacttgt 60 gtatgtcaga tagagtaaag attaactctt gcatgtgagc ggggcatcga gatagcgata 120 aatgagtcag gaggacggat acttatatgt gttgttatcc tcctctacag 170 <210> 568 <211> 122 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 568 gtgagtgtct cagttattca catcatgact cttctaacta tcttatctcc tctacctgtc 60 tctgtctttc atattcaccc acacagaaca cttgagttat acaaaccact cttatattcc 120 ag 122 <210> 569 <211> 174 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 569 gtgagtaggc atgatgttct gtgtcttgct aaccacacag tctctgcatg tgaaaagaga 60 tgataggatg agcttattaa cctcggggtg gttcatgcat gtgtcaggct gggggtggag 120 agacagctgt ggaacttagt gactcatgac agctatctct gttatcctcc acag 174 <210> 570 <211> 97 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 570 gtaagtttct gtttccattt cctctcttgt gacacatttc atgactctgc atttacataa 60 cccctgactc atggtcttcc cactcttgtt ctctcag 97 <210> 571 <211> 856 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 571 gtaagtactg cctatagata taggcgtggc tatatactat ctatagcatg ctatgcatta 60 tcttggcttt ggaccagggc gcttccgctt actcatacta tagggtgatg gtatagctta 120 acatataggt ggagctattg attgggactg ccccctattg gtgacggtgt ttcctatatc 180 tgatcaatac tatggccctc tgccatgccg cccctcttgg cctatagcca atctatcggt 240 gtcggactct gcttagaccc cctttccaac tcccagagac tgacacgcgg actctgtttg 300 tttttaagga tggctctttt attcttagac cccacaaaca ccgtccgggg ctaacagggg 360 atctccacgg cgatctcggg tacccccggc cacgggagtg tggttagtct gtcctcctcc 420 ggctcctcgg gccaggtccc cagcagctct tcttgttctt catcgtcgct gggcacctct 480 cggctgctaa ttgtcgaggc cagactcagg cagatcacga tccccaccac tattaccatg 540 ccgcccaggg ccgaggctgt ggggtatgcc tctaacaacg agcccgggga ccctacatgg 600 gtccacggac tctctgctgt ctggagactt aaggccaggg aagaagagac agatgatgaa 660 gtccctgaca gctgagaaga aaaggtaagg gagctcgtta ctcccgtggt gttgtgatag 720 ttaacagcgg tggagggtag ttgtcgctca gtcgtcactg ccgccagcag agggagacat 780 aagtacacca ggctcaacca cactgtcttc atggatgttt gcaggtagag accacacgcg 840 gcacttcacc agagag 856 <210> 572 <211> 181 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 572 gtaagtctgt tgacatgtat gtgatgtata ctaacctgca tgggacgtgg atttacttgt 60 gtatgtcaga tagagtaaag attaactctt gcatgtgagc ggggcatcga gatagcgata 120 aatgagtcag gaggacggag cctctgctaa ccatgttcat gccttcttct ttttcctaca 180 g 181 <210> 573 <211> 213 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 573 gtaagtctgt tgacatgtat gtgatgtata ctaatctgca tgggacgtgg atttacttgt 60 gtatgtcaga tagagtaaag attaactctt gcatgtgagc ggggcatcga gatagcgata 120 aatgagtcag gaggacggat acttatatgt gttgttatcc tcctctacag agcctctgct 180 aaccatgttc atgccttctt ctttttccta cag 213 <210> 574 <211> 841 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 574 gtaagtaccg cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact 60 gtttttggct tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt 120 agcctatagg tgtgggttat tgaccattat tgaccactcc cctattggtg acgatacttt 180 ccattactaa tccataacat ggctctttgc cacaactctc tttattggct atatgccaat 240 acactgtcct tcagagactg acacggactc tgtattttta caggatgggt tctcatttat 300 tatttacaaa ttcacatata caacaccacc gtccccagtg cccgcagttt ttattaaaca 360 taacgtggga tctccacgcg aatctcgggt acgtgttccg gacatgggtt cttctccggt 420 agcggcggag cttctacatc cgagccctgc tcccatgcct ccagcgactc atggtcgctc 480 ggcagctcct tgctcctaac agtggaggcc agacttaggc acagcacgat gcccaccacc 540 accagtgtgc cgcacaaggc cgtggcggta gggtatgtgt ctgaaaatga gctcggggag 600 cgggcttgca ccgctgacgc atttgaaaga cttaaggcag cggcagaaga agatgcaggc 660 agctgagttg ttgtgttctg ataagagtca gaggtaactc ccgttgcggt gctgttaacg 720 gtggagggca gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat 780 agctgacaga ctaacagaag cctctgctaa ccatgttcat gccttcttct ttttcctaca 840 g 841 <210> 575 <211> 850 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 575 gtaagtactg cctatagata taggcgtggc tatatactat ctatagcatg ctatgcatta 60 tcttggcttt ggaccagggc gcttccgctt actcatacta tagggtgatg gtatagctta 120 acatataggt ggagctattg attgggactg ccccctattg gtgacggtgt ttcctatatc 180 tgatcaatac tatggccctc tgccatgccg cccctcttgg cctatagcca atctatcggt 240 gtcggactct gcttagaccc cctttccaac tcccagagac tgacacgcgg actctgtttg 300 tttttaagga tggctctttt attcttagac cccacaaaca ccgtccgggg ctaacagggg 360 atctccacgg cgatctcggg tacccccggc cacgggagtg tggttagtct gtcctcctcc 420 ggctcctcgg gccaggtccc cagcagctct tcttgttctt catcgtcgct gggcacctct 480 cggctgctaa ttgtcgaggc cagactcagg cagatcacga tccccaccac tattaccatg 540 ccgcccaggg ccgaggctgt ggggtatgcc tctaacaacg agcccgggga ccctacatgg 600 gtccacggac tctctgctgt ctggagactt aaggccaggg aagaagagac agatgatgaa 660 gtccctgaca gctgagaaga aaaggtaagg gagctcgtta ctcccgtggt gttgtgatag 720 ttaacagcgg tggagggcag tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc 780 agacataata gctgacagac taacagaagc ctctgctaac catgttcatg ccttcttctt 840 tttcctacag 850 <210> 576 <211> 181 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 576 gtaagtctgt tgacatgtat gtgatgtata ctaacctgca tgggacgtgg atttacttgt 60 gtatgtcaga tagagtaaag attaactctt gcatgtgagc ggggcatcga gatagcgata 120 aatgagtcag gaggacggag cctctgctaa ccatgttcat gccttcttct ttttcctaca 180 g 181 <210> 577 <211> 213 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 577 gtaagtctgt tgacatgtat gtgatgtata ctaatctgca tgggacgtgg atttacttgt 60 gtatgtcaga tagagtaaag attaactctt gcatgtgagc ggggcatcga gatagcgata 120 aatgagtcag gaggacggat acttatatgt gttgttatcc tcctctacag agcctctgct 180 aaccatgttc atgccttctt ctttttccta cag 213 <210> 578 <211> 841 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 578 gtaagtaccg cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact 60 gtttttggct tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt 120 agcctatagg tgtgggttat tgaccattat tgaccactcc cctattggtg acgatacttt 180 ccattactaa tccataacat ggctctttgc cacaactctc tttattggct atatgccaat 240 acactgtcct tcagagactg acacggactc tgtattttta caggatgggt tctcatttat 300 tatttacaaa ttcacatata caacaccacc gtccccagtg cccgcagttt ttattaaaca 360 taacgtggga tctccacgcg aatctcgggt acgtgttccg gacatgggtt cttctccggt 420 agcggcggag cttctacatc cgagccctgc tcccatgcct ccagcgactc atggtcgctc 480 ggcagctcct tgctcctaac agtggaggcc agacttaggc acagcacgat gcccaccacc 540 accagtgtgc cgcacaaggc cgtggcggta gggtatgtgt ctgaaaatga gctcggggag 600 cgggcttgca ccgctgacgc atttgaaaga cttaaggcag cggcagaaga agatgcaggc 660 agctgagttg ttgtgttctg ataagagtca gaggtaactc ccgttgcggt gctgttaacg 720 gtggagggca gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat 780 agctgacaga ctaacagaag cctctgctaa ccatgttcat gccttcttct ttttcctaca 840 g 841 <210> 579 <211> 850 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 579 gtaagtactg cctatagata taggcgtggc tatatactat ctatagcatg ctatgcatta 60 tcttggcttt ggaccagggc gcttccgctt actcatacta tagggtgatg gtatagctta 120 acatataggt ggagctattg attgggactg ccccctattg gtgacggtgt ttcctatatc 180 tgatcaatac tatggccctc tgccatgccg cccctcttgg cctatagcca atctatcggt 240 gtcggactct gcttagaccc cctttccaac tcccagagac tgacacgcgg actctgtttg 300 tttttaagga tggctctttt attcttagac cccacaaaca ccgtccgggg ctaacagggg 360 atctccacgg cgatctcggg tacccccggc cacgggagtg tggttagtct gtcctcctcc 420 ggctcctcgg gccaggtccc cagcagctct tcttgttctt catcgtcgct gggcacctct 480 cggctgctaa ttgtcgaggc cagactcagg cagatcacga tccccaccac tattaccatg 540 ccgcccaggg ccgaggctgt ggggtatgcc tctaacaacg agcccgggga ccctacatgg 600 gtccacggac tctctgctgt ctggagactt aaggccaggg aagaagagac agatgatgaa 660 gtccctgaca gctgagaaga aaaggtaagg gagctcgtta ctcccgtggt gttgtgatag 720 ttaacagcgg tggagggcag tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc 780 agacataata gctgacagac taacagaagc ctctgctaac catgttcatg ccttcttctt 840 tttcctacag 850 <210> 580 <211> 1133 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 580 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta cttccacctg gctccagtac gtgattcttg atcccgagct ggagccaggg 120 gcgggccttg cgctttagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc 180 gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata 240 agtctctagc catttaaaat ttttgatgac gtgctgcgac gctttttttc tggcaagata 300 gtcttgtaaa tgcgggccag gatctgcaca ctggtatttc ggtttttggg cccgcggccg 360 gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc 420 caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg 480 cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt 540 gagcggaaag atggccgctt cccggccctg ctccaggggg ctcaaaatgg aggacgcggc 600 gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag 660 ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct 720 ggagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc 780 cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct 840 tggaatttgg cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc 900 aaagtttttt tcttccattt caggtgtcgt gaacacgtct caggggcgag accggtgagg 960 tgtggcaggc ttgagatcca gctgttgggg tgagtactcc ctctcaaaag cgggcattac 1020 ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccga 1080 tctggccata cacttgagtg acaatgacat ccactttgcc tttctctcca cag 1133 <210> 581 <211> 943 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 581 gtgagtggcg ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg ggtcggaccg 60 ccgtgcgggt gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga tggcgggctg 120 tgcgggaggg cgaggggggg aggcctggcg gcggccccgg agcctcgcct cgtgtcgggc 180 gtgaggccta gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct ttgctgtctg 240 cccggctgcc ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg cgtggagctg 300 gctggtaggg agccccgtag tccgcatgtc gggcagggag agcggcagca gtcggggggg 360 ggaccgggcc cgcccgtccc gcagcacatg tccgacgccg cctggacggg tagcggcctg 420 tgtcctgata aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg gccccgggtc 480 ccggcccggt ctggccagta ccccgtagtg gcttagctcc gaggagggcg agcccgcccg 540 cccggcacca gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag caaggagctc 600 aaaatggagg acgcggcagc ccggcggagc ggggcgggtg agtcacccac acaaaggaag 660 agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc ggccgcactt 720 cagtcacccc gggcgctctt tcggagcacc gctggcctcc gctgggggag gggatctgtc 780 taatggcgtt ggagtttgct cacatttggt gggtggagac tgtagccagg ccagcctggc 840 catggaagta attcttggaa tttgcccatt ttgagtttgg agcgaagctg attgacaaag 900 ctgcttagcc gttcaaaggt attcttcgaa cttttttttt aag 943 <210> 582 <211> 923 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 582 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta cttccacctg gctccagtac gtgattcttg atcccgagct ggagccaggg 120 gcgggccttg cgctttagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc 180 gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata 240 agtctctagc catttaaaat ttttgatgac gtgctgcgac gctttttttc tggcaagata 300 gtcttgtaaa tgcgggccag gatctgcaca ctggtatttc ggtttttggg cccgcggccg 360 gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc 420 caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg 480 cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt 540 gagcggaaag atggccgctt cccggccctg ctccaggggg ctcaaaatgg aggacgcggc 600 gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag 660 ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct 720 ggagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc 780 cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct 840 tggaatttgg cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc 900 aaagtttttt tcttccattt cag 923 <210> 583 <211> 943 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 583 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt 120 tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg 180 agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc 240 ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac 300 gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc 360 ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag 420 gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc 480 tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc 540 ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag 600 ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa 660 aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc 720 caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg 780 gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg 840 gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct 900 caagcctcag acagtggttc aaagtttttt tcttccattt cag 943 <210> 584 <211> 943 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 584 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt 120 tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg 180 agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc 240 ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac gtgctgcgac 300 gctttttttc tggcaagata gtcttgtaaa tgcgggccag gatctgcaca ctggtatttc 360 ggtttttggg cccgcggccg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag 420 gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc 480 tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc 540 ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctccaggggg 600 ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa 660 aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc 720 caggcacctc gattagttct ggagcttttg gagtacgtcg tctttaggtt ggggggaggg 780 gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg 840 gcacttgatg taattctcct tggaatttgg cctttttgag tttggatctt ggttcattct 900 caagcctcag acagtggttc aaagtttttt tcttccattt cag 943 <210> 585 <211> 938 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 585 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt cgggttggaa 120 gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt gcttgagttg 180 aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc 240 tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct gcgacgcttt 300 ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt atttcggttt 360 ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg 420 gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc cggcctgctc 480 tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg ctggcccggt 540 cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca gggagctcaa 600 aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa aggaaaaggg 660 cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg ccgtccaggc 720 acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg gaggggtttt 780 atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca gcttggcact 840 tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc attctcaagc 900 ctcagacagt ggttcaaagt ttttttcttc catttcag 938 <210> 586 <211> 948 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 586 gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc 60 gggccccgct gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg 120 cgcgggaggc agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt 180 gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt 240 tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata ggggctaaca 300 aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg gggaggaatg 360 gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc gacgccacct 420 ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag cgtgccgagg 480 ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc cctgcctccc 540 taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc 600 cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt 660 gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt cctgtgaccc 720 cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag tcgcggcggg 780 gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga ctagtcaggc 840 cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag cggagctaat 900 tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttag 948 <210> 587 <211> 944 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 587 gtgagtggcg ggtgtggctt ccgcgggccc cggagctgga gccctgctct gagcgggccg 60 ggctgatatg cgagtgtcgt ccgcagggtt tagctgtgag cattcccact tcgagtggcg 120 ggcggtgcgg gggtgagagt gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc 180 ggcttgaggc ctagcgtggt gtccgccgcc gcgtgccact ccggccgcac tatgcgtttt 240 ttgtccttgc tgccctcgat tgccttccag cagcatgggc taacaaaggg agggtgtggg 300 gctcactctt aaggagccca tgaagcttac gttggatagg aatggaaggg caggaggggc 360 gactggggcc cgcccgcctt cggagcacat gtccgacgcc acctggatgg ggcgaggcct 420 gtggctttcc gaagcaatcg ggcgtgagtt tagcctacct gggccatgtg gccctagcac 480 tgggcacggt ctggcctggc ggtgccgcgt tcccttgcct cccaacaagg gtgaggccgt 540 cccgcccggc accagttgct tgcgcggaaa gatggccgct cccggggccc tgttgcaagg 600 agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac ccacacaaag 660 gaagagggcc ttgcccctcg ccggccgctg cttcctgtga ccccgtggtc tatcggccgc 720 atagtcacct cgggcttctc ttgagcaccg ctcgtcgcgg cggggggagg ggatctaatg 780 gcgttggagt ttgttcacat ttggtgggtg gagactagtc aggccagcct ggcgctggaa 840 gtcattcttg gaatttgccc ctttgagttt ggagcgaggc taattctcaa gcctcttagc 900 ggttcaaagg tattttctaa acccgtttcc aggtgttgtg aaag 944 <210> 588 <211> 994 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 588 gtgagtttcg ggtgtggctt ccgcgggcct ggccgccttg ccttgagcgg attgaggcct 60 tcgcacgcct ttctgtccag tcgtgctgct gggtcatttt tttcgaggtt cttggccccg 120 aatttcgggt tgcgaggggt gggagagttc gaggcctagc gtttttttcg gaagcggctt 180 cgcctcgtgc ttgtgttgag gcctggtctg ggctcccggg ccgtcgcgtg cgaatcccgt 240 cgtacatttg cgccctcccc actgcctttt ctttttttcc cttctctttt ttttttttta 300 caattgggtg tcgccggctc gttgaacccc caactagcag ccgtgattcg atgccttttt 360 ccgccgtgcg tggacgggga accacacgcc cgtcggctcg cgcggggcgg cggcggctgg 420 gcccgcccgt cccggcgcac atgttctgcg cggcctcggg gaggcgaggc ggggcccggg 480 agccccggcc gccagtccgg gccggcgtgg gcttcgagta gcgggccgag cgacacagct 540 gtccggcctg ctttgagcac ccatggccgt ggctcccggc ttggcccggc ccgcccggca 600 ccagttgcgt gcgcggaaag atggccgctc ccgggcccag ttacagggag ctcaaaatgg 660 aggacgcggc gggccgggag agcgggcggg tgagtcaccc acacaaagga aaagggattt 720 tccctcttcg gtcgctgttt cctgtgaccc tgcagtgctc gggcgccgtc ccggcacctc 780 gatgtcgcct tggaggctcg gcgccctcct gccgggggag gggatttggt cccccggagt 840 ttcctctctt ggtgggtgga gactggtgtg tgaggccagc ttggcactgg ttgtaattct 900 ccttggaatt tgcccttttg agttgggacc gtggcttatt ctcaagcctc tggatggtgg 960 ttcacacaaa ggtatttttg aacttccttt ttag 994 <210> 589 <211> 849 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 589 gtgggtgctg ggtgttgctt ccgtaggcct ggcccgggcc gggagctggc ggtgggcctg 60 ccgggcctct ctcccgggca gcgcctccag ctgccgtgcg ggcctcggcc ccgagcccga 120 ggggcgcggc ctttgccttt ccagaagcct cggcctcgtg ttctggggcg aggcctggct 180 tggcgtccgg agcgccgcgt gccggttcgg gcgcgctgtg gcggctgcct gctgcctggg 240 tatcgagtcc aggccttttg ggataacaaa ggagccccgg gtggtagtcg cccgcggagc 300 ggagccgctc tctatggcag gacctccgcc cccggaccgg gcgggcccgc gcacaagcct 360 cgtgtcgctt gagcgagggg aggccttggt ccgtcgccgg gtcggtgggg gcagtttggt 420 ggcccggcgt cccgtccaac ccggggcatc ccctagttcc gcttcgggcg gccttggccg 480 ctcggcacca gttgcgtgcg cggaaagatg gccgctacgg gcctgctccg ggagctcaaa 540 atggaggacg cggcggccgg gcggtgagtc acccacacaa agagtcgggg ccttccccgc 600 cggccgccgc gtcctgtgac ccccgcggcg ctctgcccgc cattggtcac ctgggttact 660 ctatgtcgcg gtgggggagg ggaggcaggc agtgcgttgg agtttgctcg cactcggtgg 720 gtggagtcga agtcaggcca gcgtggcctc gcatgtcagt cttggagttt gcccctctcg 780 gtctggttcg tgacttactt ggctcttaca gcggttctca gacaattttt tttccacttg 840 ttgccttag 849 <210> 590 <211> 956 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 590 gtgagtgccg ggcgtggctt ccgcgggcct ggcctcccgg agcgggctgc ggccctcgcg 60 tgcctttctc tgctgctgcg ccacggagtc cctttgcgat gttcttgacc ccgaatttcg 120 ggtcgtaagt gggtgggaga gttcgaggcc ttgcgctttt ttcaggggcc ccgtcgcctc 180 gtgcttgggt gaaggcctgg ttggcgcgcc gtggctgccg cgtgcgattc ccgccgccgc 240 gccgcctcgc cggccctgtg atccagaagt ctccggccac ttgagttctc ggggaaagta 300 tccccagtgg ttttgcgtcg agggggtctg accgaggttg gtcagcgccg acggggcggg 360 cttcgctcgc gtcgcgggct cgggctgtgg ggcggcggcg ggccctccgc ccggcgcaca 420 tggcctgcga ggcggtgccc gcgagcctcg gccccgagtc gacgcgggag gaggcccgtg 480 gaggggccag gcggctccgg cgccgggctc gcgccgccgt gcgcctccct gccctgggcg 540 gcgaggccgg cctttgcccg ctcggcacca gttgcgtgcg cggaaagatg gccgctcgcg 600 gccctgtgca gggagctcaa aatggaggac gcggcggccc gggagagcgg gcgggtgagt 660 cacccgcaca aagggaaagg cttttccctc cacggccgct gcttcctgtg accccgccgt 720 gtgcccggca ccgtcccggc tcctcggttt catggccttt ggagcagggc ttcctctggt 780 tgggggaggg gacttaggcg atggagtttc cccacacttg gtgggtggag acaagagttg 840 ggccagcttg gcactggatg attctccttg gaatttgccc tttgagtttt catcgtggct 900 tgttctcaag cttgtgggac ggtggttaaa agatctcccc ccctccccct ctttag 956 <210> 591 <211> 937 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 591 gtgagtggcg ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg ggtcggaccg 60 ccgtgcgggt gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga tggcgggctg 120 tgcgggaggg cgaggggggg aggcctggcg gcggccccgg agcctcgcct cgtgtcgggc 180 gtgaggccta gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct ttgctgtctg 240 cccggctgcc ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg cgtggagctg 300 gctggtaggg agccccgtag tccgcatgtc gggcagggag agcggcagca gtcggggggg 360 ggaccgggcc cgcccgtccc gcagcacatg tccgacgccg cctggacggg tagcggcctg 420 tgtcctgata aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg gccccgggtc 480 ccggcccggt ctggccagta ccccgtagtg gcttagctcc gaggagggcg agcccgcccg 540 cccggcacca gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag caaggagctc 600 aaaatggagg acgcggcagc ccggcggagc ggggcgggtg agtcacccac acaaaggaag 660 agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc ggccgcactt 720 cagtcacccc gggcgctctt tcggagcacc gctggcctcc gctgggggag gggatctgtc 780 taatggcgtt ggagtttgct cacatttggt gggtggagac tgtagccagg ccagcctggc 840 catggaagta attcttggaa tttgcccatt ttgagtttgg agcgaagctg attgacaaag 900 ctgcttagcc gttcaaagtt tttttcttcc atttcag 937 <210> 592 <211> 943 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 592 gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc 60 gggccccgct gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg 120 cgcgggaggc agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt 180 gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt 240 ttttttttgt tgttgttgcc ctgctgcctt cgattgccgt tcagcaatag gggctaacaa 300 agggagggtg cggggcttgc tcgcccggag cccggagagg tcatggttgg ggaggaatgg 360 agggacagga gtggcggctg gggcccgccc gccttcggag cacatgtccg acgccacctg 420 gatggggcga ggcctggggt ttttcccgaa gcaaccaggc tggggttagc gtgccgaggc 480 catgtggccc cagcacccgg cacgatctgg cttggcggcg ccgcgttgcc ctgcctccct 540 aactagggtg aggccatccc gtccggcacc agttgcgtgc gtggaaagat ggccgctccc 600 gggccctgtt gcaaggagct caaaatggag gacgcggcag cccggtggag cgggcgggtg 660 agtcacccac acaaaggaag agggcctggt ccctcaccgg ctgctgcttc ctgtgacccc 720 gtggtcctat cggccgcaat agtcacctcg ggcttttgag cacggctagt cgcggcgggg 780 ggaggggatg taatggcgtt ggagtttgtt cacatttggt gggtggagac tagtcaggcc 840 agcctggcgc tggaagtcat ttttggaatt tgtccccttg agttttgagc ggagctaatt 900 ctcgggcttc ttagcggttc aaagtttttt tcttccattt cag 943 <210> 593 <211> 928 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 593 gtgagtggcg ggtgtggctt ccgcgggccc cggagctgga gccctgctct gagcgggccg 60 ggctgatatg cgagtgtcgt ccgcagggtt tagctgtgag cattcccact tcgagtggcg 120 ggcggtgcgg gggtgagagt gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc 180 ggcttgaggc ctagcgtggt gtccgccgcc gcgtgccact ccggccgcac tatgcgtttt 240 ttgtccttgc tgccctcgat tgccttccag cagcatgggc taacaaaggg agggtgtggg 300 gctcactctt aaggagccca tgaagcttac gttggatagg aatggaaggg caggaggggc 360 gactggggcc cgcccgcctt cggagcacat gtccgacgcc acctggatgg ggcgaggcct 420 gtggctttcc gaagcaatcg ggcgtgagtt tagcctacct gggccatgtg gccctagcac 480 tgggcacggt ctggcctggc ggtgccgcgt tcccttgcct cccaacaagg gtgaggccgt 540 cccgcccggc accagttgct tgcgcggaaa gatggccgct cccggggccc tgttgcaagg 600 agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac ccacacaaag 660 gaagagggcc ttgcccctcg ccggccgctg cttcctgtga ccccgtggtc tatcggccgc 720 atagtcacct cgggcttctc ttgagcaccg ctcgtcgcgg cggggggagg ggatctaatg 780 gcgttggagt ttgttcacat ttggtgggtg gagactagtc aggccagcct ggcgctggaa 840 gtcattcttg gaatttgccc ctttgagttt ggagcgaggc taattctcaa gcctcttagc 900 ggttcaaagt ttttttcttc catttcag 928 <210> 594 <211> 971 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 594 gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc 60 cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg 120 ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc 180 cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg 240 tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc 300 gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc 360 ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc 420 gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc 480 cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc 540 gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg 600 ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc 660 tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag 720 ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc 780 tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc 840 cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg 900 ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc 960 ggcggctcta g 971 <210> 595 <211> 971 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 595 gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc 60 cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg 120 ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc 180 cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg 240 tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc 300 gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc 360 ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc 420 gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc 480 cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc 540 gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg 600 ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc 660 tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag 720 ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc 780 tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc 840 cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg 900 ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc 960 ggcggctcta g 971 <210> 596 <211> 963 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 596 gtcgctgcgt tgccttcgcc ccgtgccccg ctccgcgccg cctcgcgccg cccgccccgg 60 ctctgactga ccgcgttact cccacaggtg agcgggcggg acggcccttc tcctccgggc 120 tgtaattagc gcttggttta atgacggctc gtttcttttc tgtggctgcg tgaaagcctt 180 aaagggctcc gggagggccc tttgtgcggg ggggagcggc tcggggggtg cgtgcgtgtg 240 tgtgtgcgtg gggagcgccg cgtgcggccc gcgctgcccg gcggctgtga gcgctgcggg 300 cgcggcgcgg ggctttgtgc gctccgcgtg tgcgcgaggg gagcgcggcc gggggcggtg 360 ccccgcggtg cgggggggct gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg 420 ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg cacccccctc 480 cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtgcgggg cgtggcgcgg 540 ggctcgccgt gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc 600 ctcgggccgg ggagggctcg ggggaggggc gcggcggccc cggagcgccg gcggctgtcg 660 aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg cgcagggact 720 tcctttgtcc caaatctggc ggagccgaaa tctgggaggc gccgccgcac cccctctagc 780 gggcgcgggc gaagcggtgc ggcgccggca ggaaggaaat gggcggggag ggccttcgtg 840 cgtcgccgcg ccgccgtccc cttctccatc tccagcctcg gggctgccgc agggggacgg 900 ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc 960 tag 963 <210> 597 <211> 971 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 597 gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc 60 cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg 120 ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc 180 cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg 240 tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc 300 gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc 360 ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc 420 gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc 480 cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc 540 gcggggctcg ccgtgccggg cggggggtgg cgccaggtgg gggtgccggg cggggcgggg 600 ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc 660 tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag 720 ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc 780 tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc 840 cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg 900 ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc 960 ggcggctcta g 971 <210> 598 <211> 956 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 598 gtaagcaggg acaacaggcc cagccggcca cagccctccc gtgggcagtg accgcgctgc 60 agggtcgcgg gggacactcg gcgcggacac cggggaaggc tggagggtgg tgccgggccg 120 cggagcggac actttcagat ccaactttca gtccagggtg tagacccttt acagccgcat 180 tgccacggtg tagacaccgg tggacccgct ctggctcaga gcacgcggct tgggggaacc 240 cattagggtc gcagtgtggg cgctatgaga gccgatgcag ctttcgggtg ttgaaccgta 300 tctgcccacc ttggggggag gacacaaggt cgggagccaa acgccacgat catgccttgg 360 tggcccatgg gtctttgtct aaaccggttt gcccatttgg cttgccgggc gggcgggcgc 420 ggcgggcccg gctcggccgg gtgggggctg ggttgccact gcgcttgcgc gctctatggc 480 tgggtattgg ggcgcgtgca cgctggggag ggagcccttc ctcttccccc tctcccaagt 540 taaacttgcg cgtgcgtatt gagacttgga gcgcggccac cggggttggg cgagggcggg 600 gccgttgtcc ggaaggggcg gggtcgcaga ggattcgggg cgcctgctcg cgcttcctgc 660 tgggtgtggt cgcctcccgc gcgcgcacta gaccgcccgg cgggggggcg aaggcgggtc 720 ttgcgcccgt ttggggaggg ggcggagacc tggcttcctg ccgtggggcc gcctccggac 780 cagcgtttgc ctcttatggt aataacgcgg ccggcctggg cttcatttgt cccctgagtt 840 tgggcgcgcg ccccctggcg gcccgagacc gcggcttgcc ggaagtgggc agggcggcaa 900 cggctgcgcc tagtggcccg ccagtgaccg cgaccctctt ttgtgccctg atatag 956 <210> 599 <211> 956 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 599 gtaagcaggg acaacaggcc cagccggcca cagccctccc gtgggcagtg accgcgctgc 60 agggtcgcgg gggacactcg gcgcggacac cggggaaggc tggagggtgg tgccgggccg 120 cggagcggac actttcagat ccaactttca gtccagggtg tagacccttt acagccgcat 180 tgccacggtg tagacaccgg tggacccgct ctggctcaga gcacgcggct tgggggaacc 240 cattagggtc gcagtgtggg cgctatgaga gccgatgcag ctttcgggtg ttgaaccgta 300 tctgcccacc ttggggggag gacacaaggt cgggagccaa acgccacgat catgccttgg 360 tggcccatgg gtctttgtct aaaccggttt gcccatttgg cttgccgggc gggcgggcgc 420 ggcgggcccg gctcggccgg gtgggggctg ggttgccact gcgcttgcgc gctctatggc 480 tgggtattgg ggcgcgtgca cgctggggag ggagcccttc ctcttccccc tctcccaagt 540 taaacttgcg cgtgcgtatt gagacttgga gcgcggccac cggggttggg cgagggcggg 600 gccgttgtcc ggaaggggcg gggtcgcaga ggattcgggg cgcctgctcg cgcttcctgc 660 tgggtgtggt cgcctcccgc gcgcgcacta gaccgcccgg cgggggggcg aaggcgggtc 720 ttgcgcccgt ttggggaggg ggcggacacc tggcttcctg ccgtggggcc gcctccggac 780 cagcgtttgc ctcttatggt aataacgcgg ccggcctggg cttcatttgt cccctgagtt 840 tgggcgcgcg ccccctggcg gcccgtgacc gcggcttgcc ggaagtgggc agggcggcaa 900 cggctgcgcc tagtggcccg ccagtgaccg cgaccctctt ttgtgccctg atatag 956 <210> 600 <211> 959 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 600 gtaagcaggg acgccgggcc cagcgggcct tcgctctctc gtggctagta cctcactgca 60 gggtcctgag gatcactcag aacggacacc atgggcgggt ggagggtggt gccgggccgc 120 ggagcggaca ctggcacagc caactttacg cctagcgtgt agactctttg cagccacatt 180 cccgcggtgt agacactcgt gggcccgctc ccgctcggtg cgtggggctt ggggacacac 240 tagggtcgcg gtgtgggcat ttgatgagcc ggtgcggctt gcgggtgtta aaagccgtat 300 taggtccatc ttgagagtac acagtattgg gaaccagacg ctacgatcac gcctcaatgg 360 cctctgggtc tttgtccaaa ccggtttgcc tattcggctt gccgggcggg cgggcgggcg 420 ggcgggcgcg gcagggccgg ctcggccggg tgggggctgg gatgccactg cgcgtgcgct 480 ctctatcact gggcatcgag gcgcgtgtgc gctagggagg gagctcttcc tctccccctc 540 ttcctagtta gctgcgcgtg cgtattgagg ctgggagcgc ggctgcccgg ggttgggcga 600 gggcggggcc gttgtccgga aggggcgggg tcacagtggc acgggcgcct tgtttgcgct 660 tcctgctggg tgtggtcgcc tcccgcgcgc gcacaagccg cccgtcggcg cagtgtaggc 720 ggagcttgcg cccgtttggg gagggggcgg aggtctggct tcctgcccta ggtccgcctc 780 cgggccagcg tttgcctttt atggtaataa tgcggccggt ctgcgcttcc tttgtcccct 840 gagcttgggc gcgcgccccc tggcggctcg agcccgcggc ttgccggaag tgggcagggc 900 ggcagcggct gctcttggcg gccccgaggt gactatagcc ttcttttgtg tcttgatag 959 <210> 601 <211> 959 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 601 gtaagcaggg acgccgggcc cagcgggcct tcgctctctc gtggctagta cctcactgca 60 gggtcctgag gatcactcag aacggacacc atgggcgggt ggagggtggt gccgggccgc 120 ggagcggaca ctggcacagc caactttacg cctagcgtgt agactctttg cagccacatt 180 cccgcggtgt agacactcgt gggcccgctc ccgctcggtg cgtggggctt ggggacacac 240 tagggtcgcg gtgtgggcat ttgatgagcc ggtgcggctt gcgggtgtta aaagccgtat 300 taggtccatc ttgagagtac acagtattgg gaaccagacg ctacgatcac gcctcaatgg 360 cctctgggtc tttgtccaaa ccggtttgcc tattcggctt gccgggcggg cgggcgggcg 420 ggcgggcgcg gcagggccgg ctcggccggg tgggggctgg gatgccactg cgcgtgcgct 480 ctctatcact gggcatcgag gcgcgtgtgc gctagggagg gacctcttcc tctccccctc 540 ttcctagtta gctgcgcgtg cgtattgagg ctgggagcgc ggctgcccgg ggttgggcga 600 gggcggggcc gttgtccgga aggggcgggg tcacagtggc acgggcgcct tgtttgcgct 660 tcctgctggg tgtggtcgcc tcccgcgcgc gcacaagccg cccgtcggcg cagtgtaggc 720 ggagcttgcg cccgtttggg gagggggcgg aggtctggct tcctgcccta ggtccgcctc 780 cgggccagcg tttgcctttt atggtaataa tgcggccggt ctgcgcttcc tttgtcccct 840 gagcttgggc gcgcgccccc tggcggctcg agcccgcggc ttgccggaag tgggcagggc 900 ggcagcggct gctcttggcg gccccgaggt gactatagcc ttcttttgtg tcttgatag 959 <210> 602 <211> 929 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 602 gtaagcaggg acgtcgggcc cagcgggccc caactttacc ttggccacta cctcgctgca 60 ggatcgtgag gaacactcag aagggacacc gtagaggggt ggagcgtggt accgggccgc 120 ggagcagctg gcaaagctta actttcccgg cccctagggt gtagagtgtt tgcagtcgta 180 ttcccgcggt gtggacactc gtgggtacgc tcctgcttgg tgcgcggggc ttggggacac 240 actagagtcg cggtgtgggc atttggagag ccggtgcggc tgcgggtgtt aagccgcatc 300 tgtccacctt gaggggcaac agtattgggg tcaggcgtta caatcacgct ttgatggcct 360 atgggtcttt gtccaaaccg gttttgccat tcggcttggc gggcgcggcg gggccgctcg 420 gccgggtggg ggctgggatg ccattgcgcg tgcgcgctct atcactgggc attggggccg 480 tgcgcgctgg ggagggaact cttcctctcc ccctcttccg agttaagagt tgcgcgtgcg 540 tattgagact aggagcgcgg ccgccccggg ttgggcgagg gcgggccgtc caccggaagg 600 ggcggggtcg tagcggctag gcgcctgctc gcgcttcctg ctgggtgtgg tcgcctcccg 660 cgcgcgcact agccgcccgt cgcctcagtg taggcgggcc tgtgcccgtt tggggagggg 720 cggaggcctg gcttcctgcc gtgggtccgc ctccgggcca gcgtttgcct tttatggtaa 780 taatgcggct gtcctgcgct tcctttgtcc cctgagcttg ggcgcgcccc tggcggctcg 840 aggccgcggc tcgccggaag tgggcagggc ggcagcggct gctcttggcg gctccgcggt 900 gaccatagcc ctcttttgtg ccttgatag 929 <210> 603 <211> 767 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 603 gtaagcccgg ccagccgacc ggggcatgcg gccgcggccc ttcgcccgtg cagagccgcc 60 gtctgggccg cagcgggggg cgcatggggc ggaaccggac cgccgtgggg ggcgcgggag 120 aagcccctgg gcctccggag atgggggaca ccccacgcca gttcgcaggc gcgaggccgc 180 gctcgggcgg gcgcgctccg ggggtgccgc tctcggggcg ggggcaaccg gcggggtctt 240 tgtctgagcc gggctcttgc caatggggat cgcacggtgg gcgcggcgta gcccccgtca 300 ggcccggtgg gggctggggc gccatgcgcg tgcgcgctgg tcctttgggc gctaactgcg 360 tgcgcgctgg gaattggcgc taattgcgcg tgcgcgctgg gactcaatgg cgctaatcgc 420 gcgtgcgttc tggggcccgg gcgcttgcgc cacttcctgc ccgagccgct ggcgcccgag 480 ggtgtggccg ctgcgtgcgc gcgcgcgacc cggtcgctgt ttgaaccggg cggaggcggg 540 gctggcgccc ggttgggagg gggttggggc ctggcttcct gccgcgcgcc gcggggacgc 600 ctccgaccag tgtttgcctt ttatggtaat aacgcggccg gcccggcttc ctttgtcccc 660 aatctgggcg cgcgccggcg ccccctggcg gcctaaggac tcggcgcgcc ggaagtggcc 720 agggcggggg cgacttcggc tcacagcgcg cccggctatt ctcgcag 767 <210> 604 <211> 1005 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 604 gtaagcaggg acaacaggcc cagccggcca cagccctccc gtgggcagtg accgcgctgc 60 agggtcgcgg gggacactcg gcgcggacac cggggaaggc tggagggtgg tgccgggccg 120 cggagcggac actttcagat ccaactttca gtccagggtg tagacccttt acagccgcat 180 tgccacggtg tagacaccgg tggacccgct ctggctcaga gcacgcggct tgggggaacc 240 cattagggtc gcagtgtggg cgctatgaga gccgatgcag ctttcgggtg ttgaaccgta 300 tctgcccacc ttggggggag gacacaaggt cgggagccaa acgccacgat catgccttgg 360 tggcccatgg gtctttgtct aaaccggttt gcccatttgg cttgccgggc gggcgggcgc 420 ggcgggcccg gctcggccgg gtgggggctg ggttgccact gcgcttgcgc gctctatggc 480 tgggtattgg ggcgcgtgca cgctggggag ggagcccttc ctcttccccc tctcccaagt 540 taaacttgcg cgtgcgtatt gagacttgga gcgcggccac cggggttggg cgagggcggg 600 gccgttgtcc ggaaggggcg gggtcgcaga ggattcgggg cgcctgctcg cgcttcctgc 660 tgggtgtggt cgcctcccgc gcgcgcacta gaccgcccgg cgggggggcg aaggcgggtc 720 ttgcgcccgt ttggggaggg ggcggacacc tggcttcctg ccgtggggcc gcctccggac 780 cagcgtttgc ctcttatggt aataacgcgg ccggcctggg cttcatttgt cccctgagtt 840 tgggcgcgcg ccccctggcg gcccgtgacc gcggcttgcc ggaagtgggc agggcggcaa 900 cggctgcgcc tagtggcccg ccagtgaccg cgaccctctt ttgtgccctg atatagttcg 960 ccagcctctg ctaaccatgt tcatgccttc ttctttttcc tacag 1005 <210> 605 <211> 1008 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 605 gtaagcaggg acgccgggcc cagcgggcct tcgctctctc gtggctagta cctcactgca 60 gggtcctgag gatcactcag aacggacacc atgggcgggt ggagggtggt gccgggccgc 120 ggagcggaca ctggcacagc caactttacg cctagcgtgt agactctttg cagccacatt 180 cccgcggtgt agacactcgt gggcccgctc ccgctcggtg cgtggggctt ggggacacac 240 tagggtcgcg gtgtgggcat ttgatgagcc ggtgcggctt gcgggtgtta aaagccgtat 300 taggtccatc ttgagagtac acagtattgg gaaccagacg ctacgatcac gcctcaatgg 360 cctctgggtc tttgtccaaa ccggtttgcc tattcggctt gccgggcggg cgggcgggcg 420 ggcgggcgcg gcagggccgg ctcggccggg tgggggctgg gatgccactg cgcgtgcgct 480 ctctatcact gggcatcgag gcgcgtgtgc gctagggagg gacctcttcc tctccccctc 540 ttcctagtta gctgcgcgtg cgtattgagg ctgggagcgc ggctgcccgg ggttgggcga 600 gggcggggcc gttgtccgga aggggcgggg tcacagtggc acgggcgcct tgtttgcgct 660 tcctgctggg tgtggtcgcc tcccgcgcgc gcacaagccg cccgtcggcg cagtgtaggc 720 ggagcttgcg cccgtttggg gagggggcgg aggtctggct tcctgcccta ggtccgcctc 780 cgggccagcg tttgcctttt atggtaataa tgcggccggt ctgcgcttcc tttgtcccct 840 gagcttgggc gcgcgccccc tggcggctcg agcccgcggc ttgccggaag tgggcagggc 900 ggcagcggct gctcttggcg gccccgaggt gactatagcc ttcttttgtg tcttgatagt 960 tcgccagcct ctgctaacca tgttcatgcc ttcttctttt tcctacag 1008 <210> 606 <211> 978 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 606 gtaagcaggg acgtcgggcc cagcgggccc caactttacc ttggccacta cctcgctgca 60 ggatcgtgag gaacactcag aagggacacc gtagaggggt ggagcgtggt accgggccgc 120 ggagcagctg gcaaagctta actttcccgg cccctagggt gtagagtgtt tgcagtcgta 180 ttcccgcggt gtggacactc gtgggtacgc tcctgcttgg tgcgcggggc ttggggacac 240 actagagtcg cggtgtgggc atttggagag ccggtgcggc tgcgggtgtt aagccgcatc 300 tgtccacctt gaggggcaac agtattgggg tcaggcgtta caatcacgct ttgatggcct 360 atgggtcttt gtccaaaccg gttttgccat tcggcttggc gggcgcggcg gggccgctcg 420 gccgggtggg ggctgggatg ccattgcgcg tgcgcgctct atcactgggc attggggccg 480 tgcgcgctgg ggagggaact cttcctctcc ccctcttccg agttaagagt tgcgcgtgcg 540 tattgagact aggagcgcgg ccgccccggg ttgggcgagg gcgggccgtc caccggaagg 600 ggcggggtcg tagcggctag gcgcctgctc gcgcttcctg ctgggtgtgg tcgcctcccg 660 cgcgcgcact agccgcccgt cgcctcagtg taggcgggcc tgtgcccgtt tggggagggg 720 cggaggcctg gcttcctgcc gtgggtccgc ctccgggcca gcgtttgcct tttatggtaa 780 taatgcggct gtcctgcgct tcctttgtcc cctgagcttg ggcgcgcccc tggcggctcg 840 aggccgcggc tcgccggaag tgggcagggc ggcagcggct gctcttggcg gctccgcggt 900 gaccatagcc ctcttttgtg ccttgatagt tcgccagcct ctgctaacca tgttcatgcc 960 ttcttctttt tcctacag 978 <210> 607 <211> 833 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 607 gtaagcccgg ccagccgacc ggggcatgcg gccgcggccc ttcgcccgtg cagagccgcc 60 gtctgggccg cagcgggggg cgcatggggc ggaaccggac cgccgtgggg ggcgcgggag 120 aagcccctgg gcctccggag atgggggaca ccccacgcca gttcgcaggc gcgaggccgc 180 gctcgggcgg gcgcgctccg ggggtgccgc tctcggggcg ggggcaaccg gcggggtctt 240 tgtctgagcc gggctcttgc caatggggat cgcacggtgg gcgcggcgta gcccccgtca 300 ggcccggtgg gggctggggc gccatgcgcg tgcgcgctgg tcctttgggc gctaactgcg 360 tgcgcgctgg gaattggcgc taattgcgcg tgcgcgctgg gactcaatgg cgctaatcgc 420 gcgtgcgttc tggggcccgg gcgcttgcgc cacttcctgc ccgagccgct ggcgcccgag 480 ggtgtggccg ctgcgtgcgc gcgcgcgacc cggtcgctgt ttgaaccggg cggaggcggg 540 gctggcgccc ggttgggagg gggttggggc ctggcttcct gccgcgcgcc gcggggacgc 600 ctccgaccag tgtttgcctt ttatggtaat aacgcggccg gcccggcttc ctttgtcccc 660 aatctgggcg cgcgccggcg ccccctggcg gcctaaggac tcggcgcgcc ggaagtggcc 720 agggcggcag cggctgctct tggcggcccc gaggtgacta tagccttctt ttgtgtcttg 780 atagttcgcc agcctctgct aaccatgttc atgccttctt ctttttccta cag 833 <210> 608 <211> 240 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 608 gtaaagacgg gcggagagaa acccgggagg ctagggacgg cctgaaggcg gcaggggcgg 60 gcgcaggccg gatgtgttcg cgccgctgcg gggtgggccc gggcggcctc cgcattgcag 120 gggcgggcgg aggacgtgat gcggcgcggg ctgggcatgg aggcctggtg ggggagggga 180 ggggaggcgt gtgtgtcggc cggggccact aggcgctcac tgttctctcc ctccgcgcag 240 <210> 609 <211> 240 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 609 gtgaagacgg gcggagagaa acccgggagg ctagggacgg cctgaaggcg gcaggggcgg 60 gcgcaggccg gatgtgttcg cgccgctgcg gggtgggccc gggcggcctc cgcattgcag 120 gggcgggcgg aggacgtgat gcggcgcggg ctgggcatgg aggcctggtg ggggagggga 180 ggggaggcgt gtgtgtcggc cggggccact aggcgctcac tgttctctcc ctccgcgcag 240 <210> 610 <211> 240 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 610 gtgaaaatcg cggagtgggc cgcaggaggc cggggacagt cggaaactgg gaaggggagt 60 gggcactgta cgggtctagg gatgctggtg cgaagtgtgc aagccggacc caggctccgc 120 attgcagggg ggggatgatg gaggacgtga tggggcgcac ggcgggaatg gaggcggggt 180 gggggagggg actgcctggt gtccttcggg ccacgctaat ctcattttct tctcctgcag 240 <210> 611 <211> 188 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 611 gtgtggcagg cttgagatcc agctgttggg gtgagtactc cctctcaaaa gcgggcatta 60 cttctgcgct aagattgtca gtttccaaaa acgaggagga tttgatattc acctggcccg 120 atctggccat acacttgagt gacaatgaca tccactttgc ctttctctcc acaggtgtcc 180 actcccag 188 <210> 612 <211> 193 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 612 gtgaggtgtg gcaggcttga gatccagctg ttggggtgag tactccctct caaaagcggg 60 cattacttct gcgctaagat tgtcagtttc caaaaacgag gaggatttga tattcacctg 120 gcccgatctg gccatacact tgagtgacaa tgacatccac tttgcctttc tctccacagg 180 tgtccactcc cag 193 <210> 613 <211> 1018 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 613 gtgagtgacc ccggagcggc ggtgctcggg gccggagacg gtacctcggg gctgcgggac 60 gtgtcggtgg cggtccgcgg aggccggcct gggaggagac atggctgccg gggcggcggg 120 acgtggacgg acggggcggc tggcgccatg tctgcgcgtc gggctgtggc ctcggcacgg 180 cggccgttgt cccctcggcg gacggtgctg atttggcagt gggcacagcc aggcctctgg 240 ccgccctcgg gcgtgggatc gctggtcccg tccccggcgg agggccagcg tccctttacg 300 aggtgacagc cgggtgggcg gtcttccgtt tgcacatccg cgtcccctgt ggccggcctc 360 cgcgcgtcac gtcgctgctg taggaccccc tcctgaacgg tgacgtgctc cctgctaacc 420 aaatggattc cgaaggtagc ctgggcaagg gctctcgcat cccgccatgt ggaacccgct 480 ggctttgggt ggcgcaaagc gtgtcccatg ccgagcgtct ggaggttctg tgcctccaca 540 cgtgtggacc catcgagttg tcatgagtag tgtcctgctg aggttcccac gcacttctag 600 gcactgcttg cttggctgtg aagctggggt ggcaggcgca gttttgttgc ctgtggatgc 660 gttggaagat tgggggcctt tggttattgc ggtggtgact gtctttgaga tagggtttca 720 cgtagcccag gcttgctcag gtggttagtt cagggtttgt ttagttaggg ctggacttct 780 gacgtgctgg ctgtggactc ttgatctgta tgctaacgag gtgcttgggc ttgcaggctc 840 gagtcaccgc ggactcactg ttccttatga atgacaaccg aggctccatc ttgggctgac 900 ggtcgtggtt gtagtggctg tgtgcgcact ggagtgttgt gtgggcaggc cacggccacg 960 cgtgggaaac gacatgctgc tgcctgcagt ttgctcagct gcccctcccc catcccag 1018 <210> 614 <211> 1018 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 614 gtgagtgacc ccggagcggc ggtgctcggg gccggagtcg gtacctcggg gctgcgggac 60 gtgtcggtgg cggtccgcgg aggccggcct gggaggagac atggctgccg gggcggcggg 120 acgtggacgg acggggcggc tggcgccatg tctgcgcgtc gggctgtggc ctcggcacgg 180 cggccgttgt cccctcggcg gacggtgctg atttggcagt gggcacagcc aggcctctgg 240 ccgccctcgg gcgtgggatc gctggtcccg tccccggcgg agggccagcg tccctttacg 300 aggtgacagc cgggtgggcg gacttccgtt tgcacatccg cgtcccctgt ggccggcctc 360 cgcgcgtcac gtcgctgctg taggaccccc tcctgaacgg tgacgtgctc cctgctaacc 420 aaatggattc cgaaggtagc ctgggcaagg gctctcgcat cccgccatgt ggaacccgct 480 ggctttgggt ggcgcaaagc gtgtcccatg ccgagcgtct ggaggttctg tgcctccaca 540 cgtgtggacc catcgagttg tcatgagtag tgtcctgctg aggttcccac gcacttctag 600 gcactgcttg cttggctgtg aagctggggt ggcaggcgca gttttgttgc ctgtggatgc 660 gttggaagat tgggggcctt tggttattgc ggtggtgact gtctttgaga tagggtttca 720 cgtagcccag gcttgctcag gtggttagtt cagggtttgt ttagttaggg ctggacttct 780 gacgtgctgg ctgtggactc ttgatctgta tgctaacgag gtgcttgggc ttgcaggctc 840 gagtcaccgc ggactcactg ttccttatga atgacaaccg aggctccatc ttgggctgac 900 ggtcgtggtt gtagtggctg tgtgcgcact ggagtgttgt gtgggcaggc cacggccacg 960 cgtgggaaac gacatgctgc tgcctgcagt ttgctcagct gcccctcccc catcccag 1018 <210> 615 <211> 1028 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 615 gtgagtaacc ctgcctcgct ggtgccccgg agcggcggcg gggcctccgc ggggcctacg 60 ctgcctagcc tgggacgctg gggccccccg tgccaggagg agacgtagcg gcggcggggc 120 cggaggaccc ggggctgggg aagcggccgc cgccatgtct gtgcgccgcg ctgttcaccg 180 agccctttct ccgtttccga gggcgccata accttgccca gacctggttg gagctgggtt 240 gttagcgggg atgggggtgg ggaatgatga tgtggcaggc gtagtaatgg cgggcaccgc 300 ggtggaagcg gggagacagg gaggcgcctt atgtaacccg cgggccgcga gtttgagatc 360 gattttctgc cgggggacta ggggcggcag ggaaatggca gaacgagcaa agcgacacct 420 gaaaggctcc ccttttcctt ccaaatacct tctcctgatg ctgttaatcg tcgaccttag 480 gcacttgtcc ttcctatgac tcccagatgt acaaagactc ttattgagac acgaggtgta 540 ggcttgtggc agttagggcc gttccggctc cccgttattt cctggggtgg gtggccttgt 600 ctgatcccgt ttgccaaggg gtgaccttgc attttatgat gaagcttctt gctcggggaa 660 gtttgggtgg cccggtgaca acgtggaggg ggctttagga gaggattcat cccttacgtg 720 tttggcccca aatgagactt tagtatttgt acctggtatc aaggaaatct gttgacactc 780 agttttattc ctgagcactt ttatttctgg gttgtcaatc atgaatgaca cctattaacg 840 gtggttcctt ggagattgcg gggtggctct taaggggtgt taggctggca agattcggtg 900 ggcttggggc accccagcac caaccccctc ctggccttgg gcatgctggt tcgtttggac 960 tgaacgctcc gtgccatgct gtgttcctgg aaatcacgag ctggtctgag cctccttgtc 1020 ttgcccag 1028 <210> 616 <211> 1027 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 616 gtgagtaacc ctgcctcgct ggtgccccgg agcggcggcg gggcctccgc ggggcctacg 60 ctgcctagcc tgggacgctg gggccccccg tgccaggagg agaggtagcg gcggcggggc 120 cggaggaccc ggggctgggg aagcggccgc cgccatgtct gtgcgccgcg ctgttcaccg 180 agccctttct ccgtttccga gggcgccata accttgccca gacctggttg gagctgggtt 240 gttagcgggg atgggggtgg ggaatgatga tgtggcaggc gtagtaatgg cgggcaccgc 300 ggtggaagcg gggagacagg gaggcgcctt atgtaacccg cgggccgcga gtttgagatc 360 gattttctgc cgggggacta ggggcggcag ggaatggcag aacgagcaaa gcgacacctg 420 aaaggctccc cttttccttc caaatacctt ctcctgatgc tgttaatcgt cgaccttagg 480 cacttgtcct tcctatgact cccagatgta caaagactct tattgagaca cgaggtgtag 540 gcttgtggca gttagggccg ttccggctcc ccgttatttc ctggggtggg tggccttgtc 600 tgatcccgtt tgccaagggg tgaccttgca ttttatgatg aagcttcttg ctcggggaag 660 tttgggtggc ccggtgacaa cgtggagggg gctttaggag aggattcatc ccttacgtgt 720 ttggccccaa atgagacttt agtatttgta cctggtatca aggaaatctg ttgacactca 780 gttttattcc tgagcacttt tatttctggg ttgtcaatca tgaatgacac ctattaacgg 840 tggttccttg gagattgcgg ggtggctctt aaggggtgtt aggctggcaa gattcggtgg 900 gcttggggca ccccagcacc aaccccctcc tggccttggg catgctggtt cgtttggact 960 gaacgctccg tgccatgctg tgttcctgga aatcacgagc tggtctgagc ctccttgtct 1020 tgcccag 1027 <210> 617 <211> 935 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 617 gtgagtctcc tcggctccgc tagactcggg gaccgagacg aatctctggg gcagcgggac 60 gtggctgtag cgggacgctg agagggacgg gaggaagaga catggctgcc ctggcccggg 120 cggcaggacg tggtcgggcc gcggcgccat atctgcgcgt ccctgagggc cttgggagtg 180 tcaactgccg aggtcggggt gttttcttga agtccttcaa ctccccgcgg ccgccggggt 240 gactgcggga ggggttgtgc ttggtgatgt ggcagcgggc aaagcgccgt ccccgcgccc 300 ctggtgacgg gcggagggtg tcctcgggag gtgacagcct gtagggctgg cttccttgga 360 cacctccagt gggctgaacg ccttccgggc cctttccggt agcccccgtc tctgttttct 420 atctgagttc acacgtgagc accggtcccc ataatctaag aaagtggctc actgggccta 480 gtggcgcatt gtggcctttg atccgggctt tgaccttggc gcacagcacc cagtggtttg 540 gggaagaggt gtgtgtagca gaggaggttt tttcgtgctt tggtcccaat caatccggca 600 tctttgcagt gccgaggtgg ccgtgcacct tggctttgaa ttcttgtgct gaggttatgt 660 gacttgagcc tcaagatagg gtcttctagc acaggcttgc tcttaagtgt cgcagttgtc 720 ggtttcggcg tttgtttaga gctgtggaca catctgtgaa cttttgatgc ttatttcaga 780 ggtcctgggt tgtacgtttg agtcacactg tgagctcagc tccaatcttg ggccgacatc 840 tggttcctgc ccctgctgtg gggtgctatt gacccaccga tgcctgccaa gttgggttcc 900 cagaatcagc ctggctgccc atccccccac cacag 935 <210> 618 <211> 935 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 618 gtgagtctcc tcggctccgc tagactcggg gaccgagagg aatctctggg gcagcgggac 60 gtggctgtag cgggacgctg agagggacgg gaggaagaga catggctgcc ctggcccggg 120 cggcaggacg tggtcgggcc gcggcgccat atctgcgcgt ccctgagggc cttgggagtg 180 tcaactgccg aggtcggggt gttttcttga agtccttcaa ctccccgcgg ccgccggggt 240 gactgcggga ggggttgtgc ttggtgatgt ggcagcgggc aaagcgccgt ccccgcgccc 300 ctggtgacgg gcggagggtg tcctcgggag gtgacagcct gtagggctgg cttccttgga 360 cacctccagt gggctgaacg ccttccgggc cctttccggt agcccccgtg tctgttttct 420 atctgagttc acacgtgagc accggtcccc ataatctaag aaagtggctc actgggccta 480 gtggcgcatt gtggcctttg atccgggctt tgaccttggc gcacagcacc cagtggtttg 540 gggaagaggt gtgtgtagca gaggaggttt tttcgtgctt tggtcccaat caatccggca 600 tctttgcagt gccgaggtgg ccgtgcacct tggctttgaa ttcttgtgct gaggttatgt 660 gacttgagcc tcaagatagg gtgttctagc acaggcttgc tcttaagtgt cgcagttgtc 720 ggtttcggcg tttgtttaga gctgtggaca catctgtgaa cttttgatgc ttatttcaga 780 ggtcctgggt tgtacgtttg agtcacactg tgagctcagc tccaatcttg ggccgacatc 840 tggttcctgc ccctgctgtg gggtgctatt gacccaccga tgcctgccaa gttgggttcc 900 cagaatcagc ctggctgccc atccccccac cacag 935 <210> 619 <211> 874 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 619 gtgagtgtcc gcggcgcggc aagacttggg gactgagacg agtcttcggg gcagcgggag 60 gtggccggag cgggacccgg aaaagaaagg agacatggct gcctctgcat gggtggcggg 120 acgtggtcgg ctcgcggcgc catatctgca cctcctctgc ccgtctttgg gagtgtcggc 180 ctcctgaagt tggagtgttt tctctaattc cttcgtccag ctctcctttc cgagaacgct 240 ggggtggctg tgggaggggc ggcgtttgct gatgtggcag cggacataat gctgtatagc 300 cctgtgccca tggtgacagg gtgatggtgc tcccgggaag tgacagcctg caggggtggc 360 tcacatggag acctctagtg agctgagcgt cttccgccct ggcctttatc tccttccttg 420 gtccgcacaa tggaaccggt cccctccaag ctgagaaaat ggctcatggg cctaggggcc 480 tattgtggcc tttgatccca gcatttgacc ttggcgcaca aggcgggttg gcagtgtgta 540 gcaggcgagg ttttgtcggc ctgtgtgggc cccatctcgt gcgggccccc tgtcgcctgc 600 attgttggac tgctggggtg gcagtccagc ttggcgttga ttacgtggtg cggtctcagc 660 ctaggctccc tggtactctt gttctagttg tcattttggt tagggttggg ttcctgacac 720 atctggtgac tcttgatgct tcttaggtgg taggcttgta ggtgtgagtc gaatgagcgc 780 cagttttggg gagacagctc tttggaaccc cacaatgggg tgctatcgac ccgagttccc 840 agaatcagtc ctgaccgccc ttcccccacc acag 874 <210> 620 <211> 874 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 620 gtgagtgtcc gcggcgcggc aagacttggg gactgtgacg agacttcggg gcagcgggag 60 gtggccggag cgggacccgg aaaagaaagg agacatggct gcctctgcat gggtggcggg 120 acgtggtcgg ctcgcggcgc catatctgca cctcctctgc ccgtctttgg gagtgtcggc 180 ctcctgaagt tggagtgttt tctctaattc cttcgtccag ctctcctttc cgagaacgct 240 ggggtggctg tgggaggggc ggcgtttgct gatgtggcag cggacataat gctgtatagc 300 cctgtgccca tggtgacagg gtgatggtgc tcccgggaag tgacagcctg caggggtggc 360 tcacatggtg acctctagtg agctgagcct cttccgccct ggcctttatc tccttccttg 420 gtccgcacaa tggaaccggt cccctccaag ctgagaaaat ggctcatggg cctaggggcc 480 tattgtggcc tttgatccca gcatttgacc ttggcgcaca aggcgggttg gcagtgtgta 540 gcaggcgagg ttttgtcggc ctgtgtgggc cccatctcgt gcgggccccc tgtcgcctgc 600 attgttggac tgctggggtg gcagtccagc ttggcgttga ttacgtggtg cggtcacagc 660 ctaggctccc tggtactctt gttctagttg tcattttggt tagggttggg ttcctgacac 720 atctggtgac tcttgatgct tcttaggtgg taggcttgta ggtgtgagtc gaatgagcgc 780 cagttttggg gagacagctc tttggaaccc cacaatgggg tgctatcgac ccgagttccc 840 agaatcagtc ctgaccgccc ttcccccacc acag 874 <210> 621 <211> 66 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 621 gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta 60 ttttag 66 <210> 622 <211> 530 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 622 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg 530 <210> 623 <211> 1388 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 623 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg tcacttcgct 540 tggagccacc gtccacgctg tttggagctc catagaagga accgggaccc agccagcctc 600 cgtagccggg aacggtgcat tggaacgcgg atacagcgtg ccaatagtga cgtaagtact 660 gcctatagat ataggcgtgg ctatatacta tctatagcat gctatgcatt atcttggctt 720 tggaccaggg cgcttccgct tactcatact atagggtgat ggtatagctt aacatatagg 780 tggagctatt gattgggact gccccctatt ggtgacggtg tttcctatat ctgatcaata 840 ctatggccct ctgccatgcc gcccctcttg gcctatagcc aatctatcgg tgtcggactc 900 tgcttagacc ccctttccaa ctcccagaga ctgacacgcg gactctgttt gtttttaagg 960 atggctcttt tattcttaga ccccacaaac accgtccggg gctaacaggg gatctccacg 1020 gcgatctcgg gtacccccgg ccacgggagt gtggttagtc tgtcctcctc cggctcctcg 1080 ggccaggtcc ccagcagctc ttcttgttct tcatcgtcgc tgggcacctc tcggctgcta 1140 attgtcgagg ccagactcag gcagatcacg atccccacca ctattaccat gccgcccagg 1200 gccgaggctg tggggtatgc ctctaacaac gagcccgggg accctacatg ggtccacgga 1260 ctctctgctg tctggagact taaggccagg gaagaagaga cagatgatga agtccctgac 1320 agctgagaag aaaaggtaag ggagctcgtt actcccgtgg tgttgtgata gttaacagcg 1380 gtggaggg 1388 <210> 624 <211> 1501 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 624 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg tcacttcgct 540 tggagccacc gtccacgctg tttggagctc catagaagga accgggaccc agccagcctc 600 cgtagccggg aacggtgcat tggaacgcgg atacagcgtg ccaatagtga cgtaagtact 660 gcctatagat ataggcgtgg ctatatacta tctatagcat gctatgcatt atcttggctt 720 tggaccaggg cgcttccgct tactcatact atagggtgat ggtatagctt aacatatagg 780 tggagctatt gattgggact gccccctatt ggtgacggtg tttcctatat ctgatcaata 840 ctatggccct ctgccatgcc gcccctcttg gcctatagcc aatctatcgg tgtcggactc 900 tgcttagacc ccctttccaa ctcccagaga ctgacacgcg gactctgttt gtttttaagg 960 atggctcttt tattcttaga ccccacaaac accgtccggg gctaacaggg gatctccacg 1020 gcgatctcgg gtacccccgg ccacgggagt gtggttagtc tgtcctcctc cggctcctcg 1080 ggccaggtcc ccagcagctc ttcttgttct tcatcgtcgc tgggcacctc tcggctgcta 1140 attgtcgagg ccagactcag gcagatcacg atccccacca ctattaccat gccgcccagg 1200 gccgaggctg tggggtatgc ctctaacaac gagcccgggg accctacatg ggtccacgga 1260 ctctctgctg tctggagact taaggccagg gaagaagaga cagatgatga agtccctgac 1320 agctgagaag aaaaggtaag ggagctcgtt actcccgtgg tgttgtgata gttaacagcg 1380 gtggagggca gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat 1440 agctgacaga ctaacagaag cctctgctaa ccatgttcat gccttcttct ttttcctaca 1500 g 1501 <210> 625 <211> 1507 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 625 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg tcacttcgct 540 tggagccacc gtccacgctg tttggagctc catagaagga accgggaccc agccagcctc 600 cgtagccggg aacggtgcat tggaacgcgg atacagcgtg ccaatagtga cgtaagtact 660 gcctatagat ataggcgtgg ctatatacta tctatagcat gctatgcatt atcttggctt 720 tggaccaggg cgcttccgct tactcatact atagggtgat ggtatagctt aacatatagg 780 tggagctatt gattgggact gccccctatt ggtgacggtg tttcctatat ctgatcaata 840 ctatggccct ctgccatgcc gcccctcttg gcctatagcc aatctatcgg tgtcggactc 900 tgcttagacc ccctttccaa ctcccagaga ctgacacgcg gactctgttt gtttttaagg 960 atggctcttt tattcttaga ccccacaaac accgtccggg gctaacaggg gatctccacg 1020 gcgatctcgg gtacccccgg ccacgggagt gtggttagtc tgtcctcctc cggctcctcg 1080 ggccaggtcc ccagcagctc ttcttgttct tcatcgtcgc tgggcacctc tcggctgcta 1140 attgtcgagg ccagactcag gcagatcacg atccccacca ctattaccat gccgcccagg 1200 gccgaggctg tggggtatgc ctctaacaac gagcccgggg accctacatg ggtccacgga 1260 ctctctgctg tctggagact taaggccagg gaagaagaga cagatgatga agtccctgac 1320 agctgagaag aaaaggtaag ggagctcgtt actcccgtgg tgttgtgata gttaacagcg 1380 gtggagggta gttgtcgctc agtcgtcact gccgccagca gagggagaca taagtacacc 1440 aggctcaacc acactgtctt catggatgtt tgcaggtaga gaccacacgc ggcacttcac 1500 cagagag 1507 <210> 626 <211> 833 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 626 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg tcacttcgct 540 tggagccacc gtccacgctg tttggagctc catagaagga accgggaacc tgaagtcctt 600 tgaagatatc accaaggagt gtgataagaa ccccgggaag gacattctgc aagaacttgg 660 tgagtaggca tgatgttctg tgtcttgcta accacacagt ctctgcatgt gaaaagagat 720 gataggatga gcttattaac ctcggggtgg ttcatgcatg tgtcaggctg ggggtggaga 780 gacagctgtg gaacttagtg actcatgaca gctatctctg ttatcctcca cag 833 <210> 627 <211> 846 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 627 ttcaatgtct atatatggag atccgcatat tgacgtcaat atcggtaaat ggcccacttg 60 gctgaccgcc ccacgacccc cgcccattga cgtcaatggt gggactttcc attgacgtca 120 atgggcgggg aacggatatg agccatagaa tgtactgcca agtgggccat ttaccgttca 180 ccacgcccct attgacgtca atgacggtaa atggcccgcc tggctgtacg ccaattgcat 240 catcctattg tttttctatg ggaatttccc tattggcagt acatcaacgt attactaatg 300 gggatttcca atgactaata caacgggcag tacgcccagt acgtatgact aatgggactt 360 tccataatcc cgccccattg acgtcaatgg gcatccgttc tggcaccaaa atgaatggga 420 atttccaata tgagtcataa accccgcccc attgacgcac attacacgtc aatgggcggt 480 aggcgtgccc tatgggcggt ctatataagc agagcccgtt tagtgaaccg tcacttcgct 540 tggagccacc gtccacgctg tttggagctc catagaagat accgggaccg atccagcctc 600 cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga ccctggcaga 660 actcggtaag tctgttgaca tgtatgtgat gtatactaac ctgcatggga cgtggattta 720 cttgtgtatg tcagatagag taaagattaa ctcttgcatg tgagcggggc atcgagatag 780 cgataaatga gtcaggagga cggagcctct gctaaccatg ttcatgcctt cttctttttc 840 ctacag 846 <210> 628 <211> 1011 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 628 ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg 60 gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc 120 ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc 180 atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact 240 gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact 360 tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac 420 atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat 660 agaagatacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt 720 ccccgtgcca agagtgaccc tggcagaact cggtaagtct gttgacatgt atgtgatgta 780 tactaacctg catgggacgt ggatttactt gtgtatgtca gatagagtaa agattaactc 840 ttgcatgtga gcggggcatc gagatagcga taaatgagtc aggaggacgg agcctctgct 900 aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggtagcttcc 960 ttcttctttt tcctagaagc tcagaataaa cgctcaactt tggccgccac c 1011 <210> 629 <211> 1021 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 629 ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg 60 gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc 120 ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc 180 atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact 240 gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact 360 tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac 420 atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat 660 agaagatacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt 720 ccccgtgcca agagtgaccc tggcagaact cggtaagtct gttgacatgt atgtgatgta 780 tactaacctg catgggacgt ggatttactt gtgtatgtca gatagagtaa agattaactc 840 ttgcatgtga gcggggcatc gagatagcga taaatgagtc aggaggacgg agcctctgct 900 aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg 960 ctgtctcatc attttggcaa agaatttcac cgtccttgac acgaagtttg ctgccgccac 1020 c 1021 <210> 630 <211> 1581 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 630 ggagacgact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga 60 cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat 120 gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa 180 gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca 240 tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca 300 tgctgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 360 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 420 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 480 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 540 atccacgctg ttttgacctc catagtggac accgggaccg atccagcctc cgcggccggg 600 aacggtgcat tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag 660 tctataggcc cacccccttg gcttcttatg catgctatac tgtttttggc ttggggtcta 720 tacacccccg cttcctcatg ttataggtga tggtatagct tagcctatag gtgtgggtta 780 ttgaccatta ttgaccactc ccctattggt gacgatactt tccattacta atccataaca 840 tggctctttg ccacaactct ctttattggc tatatgccaa tacactgtcc ttcagagact 900 gacacggact ctgtattttt acaggatggg ttctcattta ttatttacaa attcacatat 960 acaacaccac cgtccccagt gcccgcagtt tttattaaac ataacgtggg atctccacgc 1020 gaatctcggg tacgtgttcc ggacatgggt tcttctccgg tagcggcgga gcttctacat 1080 ccgagccctg ctcccatgcc tccagcgact catggtcgct cggcagctcc ttgctcctaa 1140 cagtggaggc cagacttagg cacagcacga tgcccaccac caccagtgtg ccgcacaagg 1200 ccgtggcggt agggtatgtg tctgaaaatg agctcgggga gcgggcttgc accgctgacg 1260 catttgaaag acttaaggca gcggcagaag aagatgcagg cagctgagtt gttgtgttct 1320 gataagagtc agaggtaact cccgttgcgg tgctgttaac ggtggagggc agtgtagtct 1380 gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag actaacagaa 1440 gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg 1500 gttattgtgc tgtctcatca ttttggcaaa gaattccgtc tcaggggaca gaccaccaat 1560 aattcaaagc aagccgccac c 1581 <210> 631 <211> 1560 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 631 ggagacgact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga 60 cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat 120 gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa 180 gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca 240 tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca 300 tgctgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 360 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 420 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 480 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 540 atccacgctg ttttgacctc catagtggac accgggaccg atccagcctc cgcggccggg 600 aacggtgcat tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag 660 tctataggcc cacccccttg gcttcttatg catgctatac tgtttttggc ttggggtcta 720 tacacccccg cttcctcatg ttataggtga tggtatagct tagcctatag gtgtgggtta 780 ttgaccatta ttgaccactc ccctattggt gacgatactt tccattacta atccataaca 840 tggctctttg ccacaactct ctttattggc tatatgccaa tacactgtcc ttcagagact 900 gacacggact ctgtattttt acaggatggg ttctcattta ttatttacaa attcacatat 960 acaacaccac cgtccccagt gcccgcagtt tttattaaac ataacgtggg atctccacgc 1020 gaatctcggg tacgtgttcc ggacatgggt tcttctccgg tagcggcgga gcttctacat 1080 ccgagccctg ctcccatgcc tccagcgact catggtcgct cggcagctcc ttgctcctaa 1140 cagtggaggc cagacttagg cacagcacga tgcccaccac caccagtgtg ccgcacaagg 1200 ccgtggcggt agggtatgtg tctgaaaatg agctcgggga gcgggcttgc accgctgacg 1260 catttgaaag acttaaggca gcggcagaag aagatgcagg cagctgagtt gttgtgttct 1320 gataagagtc agaggtaact cccgttgcgg tgctgttaac ggtggagggc agtgtagtct 1380 gagcagtact cgttgctgcc gcgcgcgcca ccagacataa tagctgacag actaacagaa 1440 gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg 1500 gtagcttcct tcttcttttt cctagaagct cagaataaac gctcaacttt ggccgccacc 1560 <210> 632 <211> 1021 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 632 ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg 60 gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc 120 ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc 180 atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact 240 gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact 360 tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac 420 atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctcgtttag tgaaccgtca gatcgcctgg agactccatc cacgctgttt tgacctccat 660 agaagatacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt 720 ccccgtgcca agagtgaccc tggcagaact cggtaagtct gttgacatgt atgtgatgta 780 tactaacctg catgggacgt ggatttactt gtgtatgtca gatagagtaa agattaactc 840 ttgcatgtga gcggggcatc gagatagcga taaatgagtc aggaggacgg agcctctgct 900 aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg 960 ctgtctcatc attttggcaa agaatttcac cgtccttgac acgaagtttg ctgccgccac 1020 c 1021 <210> 633 <211> 1582 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 633 ccaacattac cgccatgttg acttcaatgt ctatatatgg agatccgcat attgacgtca 60 atatcggtaa atggcccact tggctgaccg ccccacgacc cccgcccatt gacgtcaatg 120 gtgggacttt ccattgacgt caatgggcgg ggaacggata tgagccatag aatgtactgc 180 caagtgggcc atttaccgtt caccacgccc ctattgacgt caatgacggt aaatggcccg 240 cctggctgta cgccaattgc atcatcctat tgtttttcta tgggaatttc cctattggca 300 gtacatcaac gtattactaa tggggatttc caatgactaa tacaacgggc agtacgccca 360 gtacgtatga ctaatgggac tttccataat cccgccccat tgacgtcaat gggcatccgt 420 tctggcacca aaatgaatgg gaatttccaa tatgagtcat aaaccccgcc ccattgacgc 480 acattacacg tcaatgggcg gtaggcgtgc cctatgggcg gtctatataa gcagagcccg 540 tttagtgaac cgtcacttcg cttggagcca ccgtccacgc tgtttggagc tccatagaag 600 gaaccgggac ccagccagcc tccgtagccg ggaacggtgc attggaacgc ggatacagcg 660 tgccaatagt gacgtaagta ctgcctatag atataggcgt ggctatatac tatctatagc 720 atgctatgca ttatcttggc tttggaccag ggcgcttccg cttactcata ctatagggtg 780 atggtatagc ttaacatata ggtggagcta ttgattggga ctgcccccta ttggtgacgg 840 tgtttcctat atctgatcaa tactatggcc ctctgccatg ccgcccctct tggcctatag 900 ccaatctatc ggtgtcggac tctgcttaga ccccctttcc aactcccaga gactgacacg 960 cggactctgt ttgtttttaa ggatggctct tttattctta gaccccacaa acaccgtccg 1020 gggctaacag gggatctcca cggcgatctc gggtaccccc ggccacggga gtgtggttag 1080 tctgtcctcc tccggctcct cgggccaggt ccccagcagc tcttcttgtt cttcatcgtc 1140 gctgggcacc tctcggctgc taattgtcga ggccagactc aggcagatca cgatccccac 1200 cactattacc atgccgccca gggccgaggc tgtggggtat gcctctaaca acgagcccgg 1260 ggaccctaca tgggtccacg gactctctgc tgtctggaga cttaaggcca gggaagaaga 1320 gacagatgat gaagtccctg acagctgaga agaaaaggta agggagctcg ttactcccgt 1380 ggtgttgtga tagttaacag cggtggaggg cagtgtagtc tgagcagtac tcgttgctgc 1440 cgcgcgcgcc accagacata atagctgaca gactaacaga agcctctgct aaccatgttc 1500 atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc 1560 attttggcaa agaattgcca cc 1582 <210> 634 <211> 1669 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 634 ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg 60 gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc 120 ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc 180 atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact 240 gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact 360 tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac 420 atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctcgtttag tgaaccgtca gatcgcctgg agactccatt cacttcgctt ggagccaccg 660 tccacgctgt ttggagctcc atagaaggaa ccgggaccca gccagcctcc gtagccggga 720 acggtgcatt ggaacgcgga tacagcgtgc caatagtgac gtaagtactg cctatagata 780 taggcgtggc tatatactat ctatagcatg ctatgcatta tcttggcttt ggaccagggc 840 gcttccgctt actcatacta tagggtgatg gtatagctta acatataggt ggagctattg 900 attgggactg ccccctattg gtgacggtgt ttcctatatc tgatcaatac tatggccctc 960 tgccatgccg cccctcttgg cctatagcca atctatcggt gtcggactct gcttagaccc 1020 cctttccaac tcccagagac tgacacgcgg actctgtttg tttttaagga tggctctttt 1080 attcttagac cccacaaaca ccgtccgggg ctaacagggg atctccacgg cgatctcggg 1140 tacccccggc cacgggagtg tggttagtct gtcctcctcc ggctcctcgg gccaggtccc 1200 cagcagctct tcttgttctt catcgtcgct gggcacctct cggctgctaa ttgtcgaggc 1260 cagactcagg cagatcacga tccccaccac tattaccatg ccgcccaggg ccgaggctgt 1320 ggggtatgcc tctaacaacg agcccgggga ccctacatgg gtccacggac tctctgctgt 1380 ctggagactt aaggccaggg aagaagagac agatgatgaa gtccctgaca gctgagaaga 1440 aaaggtaagg gagctcgtta ctcccgtggt gttgtgatag ttaacagcgg tggagggcag 1500 tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc agacataata gctgacagac 1560 taacagaagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca 1620 acgtgctggt tattgtgctg tctcatcatt ttggcaaaga attgccacc 1669 <210> 635 <211> 1088 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 635 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgc tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcctcact 540 cactctcttc cgcatcgctg tctgcgaggg ccagctgttg ggctcgcggt tgaggacaaa 600 ctcttcgcgg tctttccagt actcttggat cggaaacccg tcggcctccg aacggtactc 660 cgccaccgag ggacctgagc gagtccgcat cgaccggatc ggaaaacctc tcgagaaagg 720 cgtctaacca gtcacagtcg caaggtaggc tgagcaccgt ggcgggcggc agcgggtggc 780 ggtcggggtt gtttctggcg gaggtgctgc tgatgatgta attaaagtag gcggtcttga 840 gactgcggat ggtcgaggtg aggtgtggca ggcttgagat ccagctgttg gggtgagtac 900 tccctctcaa aagcgggcat tacttctgcg ctaagattgt cagtttccaa aaacgaggag 960 gatttgatat tcacctggcc cgatctggcc atacacttga gtgacaatga catccacttt 1020 gcctttctct ccacaggtgt ccactcccag cgtctcaggg gacacccaag ctgtctagag 1080 ccgccacc 1088 <210> 636 <211> 878 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 636 ccaacattac cgccatgttg acttcaatgt ctatatatgg agatccgcat attgacgtca 60 atatcggtaa atggcccact tggctgaccg ccccacgacc cccgcccatt gacgtcaatg 120 gtgggacttt ccattgacgt caatgggcgg ggaacggata tgagccatag aatgtactgc 180 caagtgggcc atttaccgtt caccacgccc ctattgacgt caatgacggt aaatggcccg 240 cctggctgta cgccaattgc atcatcctat tgtttttcta tgggaatttc cctattggca 300 gtacatcaac gtattactaa tggggatttc caatgactaa tacaacgggc agtacgccca 360 gtacgtatga ctaatgggac tttccataat cccgccccat tgacgtcaat gggcatccgt 420 tctggcacca aaatgaatgg gaatttccaa tatgagtcat aaaccccgcc ccattgacgc 480 acattacacg tcaatgggcg gtaggcgtgc cctatgggcg gtctatataa gcagagcccg 540 tttagtgaac cgtcacttcg cttggagcca ccgtccacgc tgtttggagc tccatagaag 600 gaaccgggaa cctgaagtcc tttgaagata tcaccaagga gtgtgataag aaccccggga 660 aggacattct gcaagaactt ggtgagtagg catgatgttc tgtgtcttgc taaccacaca 720 gtctctgcat gtgaaaagag atgataggat gagcttatta acctcggggt ggttcatgca 780 tgtgtcaggc tgggggtgga gagacagctg tggaacttag tgactcatga cagctatctc 840 tgttatcctc cacagttaag cagattaagg ccgccacc 878 <210> 637 <211> 930 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 637 ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg 60 gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc 120 ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc 180 atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact 240 gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat 300 gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact 360 tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac 420 atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac 480 gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac 540 tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga 600 gctcgtttag tgaaccgtca gatcgcctgg agactccata gctccataga aggaaccggg 660 aacctgaagt cctttgaaga tatcaccaag gagtgtgata agaaccccgg gaaggacatt 720 ctgcaagaac ttggtgagta ggcatgatgt tctgtgtctt gctaaccaca cagtctctgc 780 atgtgaaaag agatgatagg atgagcttat taacctcggg gtggttcatg catgtgtcag 840 gctgggggtg gagagacagc tgtggaactt agtgactcat gacagctatc tctgttatcc 900 tccacagtta agcagattaa ggccgccacc 930 <210> 638 <211> 895 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 638 gaattcgttt atcggccacc gaggccaaga tctggccgcc aattgattat tgactagtta 60 ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac 120 ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 180 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 240 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc 300 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 360 cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt 420 gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc 480 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 540 tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg 600 ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gactccatat 660 cgccgatcag gcatccgtca acgcccacgg ccgtcacttg gataagaacc gtgtctaccc 720 atcagacaag taagtttctg tttccatttc ctctcttgtg acacatttca tgactctgca 780 tttacataac ccctgactca tggtcttccc actcttgttc tctcagggtg ccagctcagc 840 ttccttcttc tttttcctag aagctcagaa taaacgctca actttggccg ccacc 895 <210> 639 <211> 623 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 639 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcgtct caggggacac 600 ccaagctgtc tagagccgcc acc 623 <210> 640 <211> 1695 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 640 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga 300 ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt 360 gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggcgcg 420 cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg 480 cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc 540 ggccctataa aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg 600 tgccccgctc cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc 660 cacaggtgag cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat 720 gacggcttgt ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt 780 tgtgcggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt 840 gcggctccgc gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc 900 tccgcagtgt gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct 960 gcgaggggaa caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg 1020 gcgcgtcggt cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc 1080 cggcttcggg tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg 1140 ggtggcggca ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg 1200 gggaggggcg cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc 1260 attgcctttt atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg 1320 cggagccgaa atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt 1380 gcggcgccgg caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc 1440 cccttctccc tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac 1500 ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc 1560 atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt 1620 ctcatcattt tggcaaagaa ttcggcttga tcgaagccgt ctcaggggac acccaagctg 1680 tctagagccg ccacc 1695 <210> 641 <211> 870 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 641 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgaccctggc agaactcggt aagtctgttg 660 acatgtatgt gatgtatact aacctgcatg ggacgtggat ttacttgtgt atgtcagata 720 gagtaaagat taactcttgc atgtgagcgg ggcatcgaga tagcgataaa tgagtcagga 780 ggacggatac ttatatgtgt tgttatcctc ctctacagtc aaacagatta agcgtctcag 840 gggacaccca agctgtctag agccgccacc 870 <210> 642 <211> 1937 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 642 actacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 60 atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 120 tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 180 cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 240 tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac caatgacgtc 300 gaggagaagt tccccaactt tcccgcctct cagcctttga aagaaagaaa ggggaggggg 360 caggccgcgt gcagccgcga gcggtgctgg gctccggctc caattcccca tctcagtcgt 420 tcccaaagtc ctcctgtttc atccaagcgt gtaagggtcc ccgtccttga ctccctagtg 480 tcctgctgcc cacagtccag tcctgggaac cagcaccgat cacctcccat cgggccaatc 540 tcagtccctt cccccctacg tcggggccca cacgctcggt gcgtgcccag ttgaaccagg 600 cggctgcgga aaaaaaaaag cggggagaaa gtagggcccg gctactagcg gttttacggg 660 cgcacgtagc tcaggcctca agaccttggg ctgggactgg ctgagcctgg cgggaggcgg 720 ggtccgagtc accgcctgcc gccgcgcccc cggtttctat aaattgagcc cgcagcctcc 780 cgcttcgctc tctgctcctc ctgttcgaca gtcaggagtc gctgcgcgct gccttcgccc 840 cgtgccccgc tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact 900 cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta 960 atgacggctt gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc 1020 tttgtgcggg gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc 1080 gtgcggctcc gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc 1140 gctccgcagt gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg 1200 ctgcgagggg aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt 1260 gggcgcgtcg gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg 1320 cccggcttcg ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg 1380 ggggtggcgc caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc 1440 gggggagggg cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag 1500 ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg 1560 tgcggagccg aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg 1620 gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg 1680 tccccttctc cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg 1740 acggggcagg gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa 1800 ccatgttcat gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct 1860 gtctcatcat tttggcaaag aattcggctt gatcgaagcc gtctcagggg acacccaagc 1920 tgtctagagc cgccacc 1937 <210> 643 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 643 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 644 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 644 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 645 <211> 1133 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 645 actacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 60 atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 120 tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 180 cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 240 tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac caatgacgtc 300 gaggagaagt tccccaactt tcccgcctct cagcctttga aagaaagaaa ggggaggggg 360 caggccgcgt gcagccgcga gcggtgctgg gctccggctc caattcccca tctcagtcgt 420 tcccaaagtc ctcctgtttc atccaagcgt gtaagggtcc ccgtccttga ctccctagtg 480 tcctgctgcc cacagtccag tcctgggaac cagcaccgat cacctcccat cgggccaatc 540 tcagtccctt cccccctacg tcggggccca cacgctcggt gcgtgcccag ttgaaccagg 600 cggctgcgga aaaaaaaaag cggggagaaa gtagggcccg gctactagcg gttttacggg 660 cgcacgtagc tcaggcctca agaccttggg ctgggactgg ctgagcctgg cgggaggcgg 720 ggtccgagtc accgcctgcc gccgcgcccc cggtttctat aaattgagcc cgcagcctcc 780 cgcttcgctc tctgctcctc ctgttcgaca gtcagccgca tcttcttttg cgtcgccagg 840 taaagacggg cggagagaaa cccgggaggc tagggacggc ctgaaggcgg caggggcggg 900 cgcaggccgg atgtgttcgc gccgctgcgg ggtgggcccg ggcggcctcc gcattgcagg 960 ggcgggcgga ggacgtgatg cggcgcgggc tgggcatgga ggcctggtgg gggaggggag 1020 gggaggcgtg tgtgtcggcc ggggccacta ggcgctcact gttctctccc tccgcgcagc 1080 cgagccacat cgctccgtct caggggacac ccaagctgtc tagagccgcc acc 1133 <210> 646 <211> 534 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 646 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccagcacatc 300 gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag 360 gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg 420 tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt 480 tgccgccaga acacagcgtc tcaggggaca cccaagctgt ctagagccgc cacc 534 <210> 647 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 647 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 648 <211> 878 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 648 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaatgacgt 300 cgaggagaag ttccccaact ttcccgcctc tcagcctttg aaagaaagaa aggggagggg 360 gcaggccgcg tgcagccgcg agcggtgctg ggctccggct ccaattcccc atctcagtcg 420 ttcccaaagt cctcctgttt catccaagcg tgtaagggtc cccgtccttg actccctagt 480 gtcctgctgc ccacagtcca gtcctgggaa ccagcaccga tcacctccca tcgggccaat 540 ctcagtccct tcccccctac gtcggggccc acacgctcgg tgcgtgccca gttgaaccag 600 gcggctgcgg aaaaaaaaaa gcggggagaa agtagggccc ggctactagc ggttttacgg 660 gcgcacgtag ctcaggcctc aagaccttgg gctgggactg gctgagcctg gcgggaggcg 720 gggtccgagt caccgcctgc cgccgcgccc ccggtttcta taaattgagc ccgcagcctc 780 ccgcttcgct ctctgctcct cctgttcgac agtcagccgc atcttctttt gcgtcgccag 840 cgtctcaggg gacacccaag ctgtctagag ccgccacc 878 <210> 649 <211> 1489 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 649 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccagcacatc 300 gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag 360 gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg 420 tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt 480 tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg 540 ttatggccct tgcgtgcctt gaattacttc cacgcccctg gctgcagtac gtgattcttg 600 atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc 660 cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct 720 ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt 780 gatgacgtgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaggatc 840 tgcacactgg tatttcggtt tttgggcccg cggccggcga cggggcccgt gcgtcccagc 900 gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt 960 ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct 1020 gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg 1080 gccctgctcc agggggctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt 1140 cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg 1200 agtaccgggc gccgtccagg cacctcgatt agttctggag cttttggagt acgtcgtctt 1260 taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg 1320 aagttaggcc agcttggcac ttgatgtaat tctccttgga atttggcctt tttgagtttg 1380 gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg 1440 tgtcgtgaac acgtctcagg ggacacccaa gctgtctaga gccgccacc 1489 <210> 650 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 650 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 651 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 651 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 652 <211> 558 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 652 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc cgtctcaggg gacacccaag 540 ctgtctagag ccgccacc 558 <210> 653 <211> 1133 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 653 actacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 60 atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 120 tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 180 cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 240 tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac caatgacgtc 300 gaggagaagt tccccaactt tcccgcctct cagcctttga aagaaagaaa ggggaggggg 360 caggccgcgt gcagccgcga gcggtgctgg gctccggctc caattcccca tctcagtcgt 420 tcccaaagtc ctcctgtttc atccaagcgt gtaagggtcc ccgtccttga ctccctagtg 480 tcctgctgcc cacagtccag tcctgggaac cagcaccgat cacctcccat cgggccaatc 540 tcagtccctt cccccctacg tcggggccca cacgctcggt gcgtgcccag ttgaaccagg 600 cggctgcgga aaaaaaaaag cggggagaaa gtagggcccg gctactagcg gttttacggg 660 cgcacgtagc tcaggcctca agaccttggg ctgggactgg ctgagcctgg cgggaggcgg 720 ggtccgagtc accgcctgcc gccgcgcccc cggtttctat aaattgagcc cgcagcctcc 780 cgcttcgctc tctgctcctc ctgttcgaca gtcagccgca tcttcttttg cgtcgccagg 840 taaagacggg cggagagaaa cccgggaggc tagggacggc ctgaaggcgg caggggcggg 900 cgcaggccgg atgtgttcgc gccgctgcgg ggtgggcccg ggcggcctcc gcattgcagg 960 ggcgggcgga ggacgtgatg cggcgcgggc tgggcatgga ggcctggtgg gggaggggag 1020 gggaggcgtg tgtgtcggcc ggggccacta ggcgctcact gttctctccc tccgcgcagc 1080 cgagccacat cgctccgtct caggggacac ccaagctgtc tagagccgcc acc 1133 <210> 654 <211> 361 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 654 ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt 60 agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca 120 tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa 180 ctccgcccag ttccgcccat tctccgcccc atcgctgact aatttttttt atttatgcag 240 aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag 300 gcctaggctt ttgcaaaaag cttcgtctca ggggacaccc aagctgtcta gagccgccac 360 c 361 <210> 655 <211> 1469 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 655 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccagcacatc 300 gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag 360 gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg 420 tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt 480 tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg 540 ttatggccct tgcgtgcctt gaattacttc cacctggctc cagtacgtga ttcttgatcc 600 cgagctggag ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg tgcttgagtt 660 gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt 720 ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacgtgc tgcgacgctt 780 tttttctggc aagatagtct tgtaaatgcg ggccaggatc tgcacactgg tatttcggtt 840 tttgggcccg cggccggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg 900 ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct 960 ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg 1020 tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc agggggctca 1080 aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg 1140 gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg 1200 cacctcgatt agttctggag cttttggagt acgtcgtctt taggttgggg ggaggggttt 1260 tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac 1320 ttgatgtaat tctccttgga atttggcctt tttgagtttg gatcttggtt cattctcaag 1380 cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcctgaac acgtctcagg 1440 ggacacccaa gctgtctaga gccgccacc 1469 <210> 656 <211> 1062 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 656 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc ctcactctct tccgcatcgc 540 tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca aactcttcgc ggtctttcca 600 gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg agggacctga 660 gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt 720 cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg gcggtcgggg ttgtttctgg 780 cggaggtgct gctgatgatg taattaaagt aggcggtctt gagacggcgg atggtcgagg 840 tgaggtgtgg caggcttgag atccagctgt tggggtgagt actccctctc aaaagcgggc 900 attacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg 960 cccgatctgg ccatacactt gagtgacaat gacatccact ttgcctttct ctccacaggt 1020 gtccactccc aggggacacc caagctgtct agagccgcca cc 1062 <210> 657 <211> 1516 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 657 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatgctgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagag gccatccacg 540 ctgttttgac ctccatagtg gacaccggga ccgatccagc ctccgcggcc gggaacggtg 600 cattggaacg cggattcccc gtgccaagag tgacgtaagt accgcctata gagtctatag 660 gcccaccccc ttggcttctt atgcatgcta tactgttttt ggcttggggt ctatacaccc 720 ccgcttcctc atgttatagg tgatggtata gcttagccta taggtgtggg ttattgacca 780 ttattgacca ctcccctatt ggtgacgata ctttccatta ctaatccata acatggctct 840 ttgccacaac tctctttatt ggctatatgc caatacactg tccttcagag actgacacgg 900 actctgtatt tttacaggat gggttctcat ttattattta caaattcaca tatacaacac 960 caccgtcccc agtgcccgca gtttttatta aacataacgt gggatctcca cgcgaatctc 1020 gggtacgtgt tccggacatg ggttcttctc cggtagcggc ggagcttcta catccgagcc 1080 ctgctcccat gcctccagcg actcatggtc gctcggcagc tccttgctcc taacagtgga 1140 ggccagactt aggcacagca cgatgcccac caccaccagt gtgccgcaca aggccgtggc 1200 ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct tgcaccgctg acgcatttga 1260 aagacttaag gcagcggcag aagaagatgc aggcagctga gttgttgtgt tctgataaga 1320 gtcagaggta actcccgttg cggtgctgtt aacggtggag ggcagtgtag tctgagcagt 1380 actcgttgct gccgcgcgcg ccaccagaca taatagctga cagactaaca gactgttcct 1440 ttccatgggt cttttctgca gtcaccgtcc ttgacacgcg tctcagggga cacccaagct 1500 gtctagagcc gccacc 1516 <210> 658 <211> 1062 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 658 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat 300 gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag 360 tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc 420 aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga 480 ggtctatata agcagagctc gtttagtgaa ccgtcagatc ctcactctct tccgcatcgc 540 tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca aactcttcgc ggtctttcca 600 gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg agggacctga 660 gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt 720 cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg gcggtcgggg ttgtttctgg 780 cggaggtgct gctgatgatg taattaaagt aggcggtctt gagacggcgg atggtcgagg 840 tgaggtgtgg caggcttgag atccagctgt tggggtgagt actccctctc aaaagcgggc 900 attacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg 960 cccgatctgg ccatacactt gagtgacaat gacatccact ttgcctttct ctccacaggt 1020 gtccactccc aggggacacc caagctgtct agagccgcca cc 1062 <210> 659 <211> 1080 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 659 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaatgacgt 300 cgaggagaag ttccccaact ttcccgcctc tcagcctttg aaagaaagaa aggggagggg 360 gcaggccgcg tgcagccgcg agcggtgctg ggctccggct ccaattcccc atctcagtcg 420 ttcccaaagt cctcctgttt catccaagcg tgtaagggtc cccgtccttg actccctagt 480 gtcctgctgc ccacagtcca gtcctgggaa ccagcaccga tcacctccca tcgggccaat 540 ctcagtccct tcccccctac gtcggggccc acacgctcgg tgcgtgccca gttgaaccag 600 gcggctgcgg aaaaaaaaaa gcggggagaa agtagggccc ggctactagc ggttttacgg 660 gcgcacgtag ctcaggcctc aagaccttgg gctgggactg gctgagcctg gcgggaggcg 720 gggtccgagt caccgcctgc cgccgcgccc ccggtttcta taaattgagc ccgcagcctc 780 ccgcttcgct ctctgctcct cctgttcgac agtcagccgc atcttctttt gcgtcgccag 840 cgtctcaggg gccctggcag aactcggtaa gtctgttgac atgtatgtga tgtatactaa 900 cctgcatggg acgtggattt acttgtgtat gtcagataga gtaaagatta actcttgcat 960 gtgagcgggg catcgagata gcgataaatg agtcaggagg acggatactt atatgtgttg 1020 ttatcctcct ctacagtcaa acagattaag gggacaccca agctgtctag agccgccacc 1080 <210> 660 <211> 1043 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 660 caacctttgg agctaagcca gcaatggtag agggaagatt ctgcacgtcc cttccaggcg 60 gcctccccgt caccaccccc cccaacccgc cccgaccgga gctgagagta attcatacaa 120 aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc actaacgtag 180 aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat cactgaggtg 240 gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag 300 tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga aggtggcgcg 360 gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag 420 aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca 480 gaacacagcg tctcaggggc tctcactctc ttccgcatcg ctgtctgcga gggccagctg 540 ttgggctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac 600 ccgtcggcct ccgaacggta ctccgccacc gagggacctg agcgagtccg catcgaccgg 660 atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac 720 cgtggcgggc ggcagcgggt ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat 780 gtaattaaag taggcggtct tgagagggcg gatggtcgag gtgaggtgtg gcaggcttga 840 gatccagctg ttggggtgag tactccctct caaaagcggg cattacttct gcgctaagat 900 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgatctg gccatacact 960 tgagtgacaa tgacatccac tttgcctttc tctccacagg tgtccactcc caggggacac 1020 ccaagctgtc tagagccgcc acc 1043 <210> 661 <211> 1076 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 661 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaatgacgt 300 cgaggagaag ttccccaact ttcccgcctc tcagcctttg aaagaaagaa aggggagggg 360 gcaggccgcg tgcagccgcg agcggtgctg ggctccggct ccaattcccc atctcagtcg 420 ttcccaaagt cctcctgttt catccaagcg tgtaagggtc cccgtccttg actccctagt 480 gtcctgctgc ccacagtcca gtcctgggaa ccagcaccga tcacctccca tcgggccaat 540 ctcagtccct tcccccctac gtcggggccc acacgctcgg tgcgtgccca gttgaaccag 600 gcggctgcgg aaaaaaaaaa gcggggagaa agtagggccc ggctactagc ggttttacgg 660 gcgcacgtag ctcaggcctc aagaccttgg gctgggactg gctgagcctg gcgggaggcg 720 gggtccgagt caccgcctgc cgccgcgccc ccggtttcta taaattgagc ccgcagcctc 780 ccgcttcgct ctctgctcct cctgttcgac agtcagccgc atcttctttt gcgtcgccag 840 cgtctcaggg gcggtgaggt gtggcaggct tgagatccag ctgttggggt gagtactccc 900 tctcaaaagc gggcattact tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt 960 tgatattcac ctggcccgat ctggccatac acttgagtga caatgacatc cactttgcct 1020 ttctctccac aggtgtccac tcccagggga cacccaagct gtctagagcc gccacc 1076 <210> 662 <211> 1080 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 662 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaatgacgt 300 cgaggagaag ttccccaact ttcccgcctc tcagcctttg aaagaaagaa aggggagggg 360 gcaggccgcg tgcagccgcg agcggtgctg ggctccggct ccaattcccc atctcagtcg 420 ttcccaaagt cctcctgttt catccaagcg tgtaagggtc cccgtccttg actccctagt 480 gtcctgctgc ccacagtcca gtcctgggaa ccagcaccga tcacctccca tcgggccaat 540 ctcagtccct tcccccctac gtcggggccc acacgctcgg tgcgtgccca gttgaaccag 600 gcggctgcgg aaaaaaaaaa gcggggagaa agtagggccc ggctactagc ggttttacgg 660 gcgcacgtag ctcaggcctc aagaccttgg gctgggactg gctgagcctg gcgggaggcg 720 gggtccgagt caccgcctgc cgccgcgccc ccggtttcta taaattgagc ccgcagcctc 780 ccgcttcgct ctctgctcct cctgttcgac agtcagccgc atcttctttt gcgtcgccag 840 cgtctcaggg gccctggcag aactcggtaa gtctgttgac atgtatgtga tgtatactaa 900 cctgcatggg acgtggattt acttgtgtat gtcagataga gtaaagatta actcttgcat 960 gtgagcgggg catcgagata gcgataaatg agtcaggagg acggatactt atatgtgttg 1020 ttatcctcct ctacagtcaa acagattaag gggacaccca agctgtctag agccgccacc 1080 <210> 663 <211> 1043 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 663 caacctttgg agctaagcca gcaatggtag agggaagatt ctgcacgtcc cttccaggcg 60 gcctccccgt caccaccccc cccaacccgc cccgaccgga gctgagagta attcatacaa 120 aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc actaacgtag 180 aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat cactgaggtg 240 gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag 300 tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga aggtggcgcg 360 gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag 420 aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca 480 gaacacagcg tctcaggggc tctcactctc ttccgcatcg ctgtctgcga gggccagctg 540 ttgggctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac 600 ccgtcggcct ccgaacggta ctccgccacc gagggacctg agcgagtccg catcgaccgg 660 atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac 720 cgtggcgggc ggcagcgggt ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat 780 gtaattaaag taggcggtct tgagagggcg gatggtcgag gtgaggtgtg gcaggcttga 840 gatccagctg ttggggtgag tactccctct caaaagcggg cattacttct gcgctaagat 900 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgatctg gccatacact 960 tgagtgacaa tgacatccac tttgcctttc tctccacagg tgtccactcc caggggacac 1020 ccaagctgtc tagagccgcc acc 1043 <210> 664 <211> 697 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 664 attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 60 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 120 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 180 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 240 tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 300 attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag 360 tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt 420 ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 480 accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg 540 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga 600 tcgcctgtag acgccatcca cgctgttttg acctccatag aagacaccgg gaccgatcca 660 gcctccgggg acacccaagc tgtctagagc cgccacc 697 <210> 665 <211> 1670 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 665 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaacccgcc 300 ccgaccggag ctgagagtaa ttcatacaaa aggactcgcc cctgccttgg ggaatcccag 360 ggaccgtcgt taaactccca ctaacgtaga acccagagat cgctgcgttc ccgccccctc 420 acccgcccgc tctcgtcatc actgaggtgg agaatagcat gcgtgaggct ccggtgcccg 480 tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa 540 ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg 600 gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa 660 cgttcttttt cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg 720 cgggcctggc ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct 780 ccagtacgtg attcttgatc ccgagctgga gccaggggcg ggccttgcgc tttaggagcc 840 ccttcgcctc gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc 900 tggtggcacc ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt 960 tgatgacgtg ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaggat 1020 ctgcacactg gtatttcggt ttttgggccc gcggccggcg acggggcccg tgcgtcccag 1080 cgcacatgtt cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag 1140 tctcaagctg gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc 1200 tgggcggcaa ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc 1260 ggccctgctc cagggggctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag 1320 tcacccacac aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg 1380 gagtaccggg cgccgtccag gcacctcgat tagttctgga gcttttggag tacgtcgtct 1440 ttaggttggg gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact 1500 gaagttaggc cagcttggca cttgatgtaa ttctccttgg aatttggcct ttttgagttt 1560 ggatcttggt tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag 1620 gtgtcctgaa cacgtctcag gggacaccca agctgtctag agccgccacc 1670 <210> 666 <211> 1469 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 666 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 60 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 120 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc 180 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 240 acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccagcacatc 300 gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag 360 gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg 420 tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt 480 tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg 540 ttatggccct tgcgtgcctt gaattacttc cacctggctc cagtacgtga ttcttgatcc 600 cgagctggag ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg tgcttgagtt 660 gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt 720 ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacgtgc tgcgacgctt 780 tttttctggc aagatagtct tgtaaatgcg ggccaggatc tgcacactgg tatttcggtt 840 tttgggcccg cggccggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg 900 ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct 960 ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg 1020 tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc agggggctca 1080 aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg 1140 gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg 1200 cacctcgatt agttctggag cttttggagt acgtcgtctt taggttgggg ggaggggttt 1260 tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac 1320 ttgatgtaat tctccttgga atttggcctt tttgagtttg gatcttggtt cattctcaag 1380 cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcctgaac acgtctcagg 1440 ggacacccaa gctgtctaga gccgccacc 1469 <210> 667 <211> 1311 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 667 gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg 60 ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc 120 caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg 180 ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt 240 ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt 300 ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt 360 caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg 420 gtgactagta aatcaacggg accgaagaac aacgaggaga agatcctcaa cttttccgca 480 gccttttcaa taatggggag aggttcgatg atgcagtggc agggtgaccc acacttctcc 540 atttcccctg ttctcccatt ttactcggga agcagcattc aggtttctgg gtcctggatg 600 tccttggtgc acactccaag gactcctcgt ccttaagttc atagtctgta ttccctgagt 660 cctatcctgg gaaccatcac ccggtcacct cctgagcggg gcaatctcag ctcccctccc 720 cctatcagtt cggagcccac acgcttggtg cgtgcacatt tcaaaaatga ggcgggtcca 780 aagagaggga ggaggggaaa tgagagaggc ccagctactc gcggctttac gggtgcacgt 840 agctcaggcc tctgcgccct tgagctagga ctggataagc agggcgggag gcggggcgcg 900 cgtcatcagc tcccccccac catccgggtt cctataaata cggactgcag ccctccctgg 960 tgctctctgc tcctccctgt tccagagtcg gccgcatctt cttgtgcagt gccaggtgaa 1020 aatcgcggag tgggccgcag gaggccgggg acagtcggaa actgggaagg ggagtgggca 1080 ctgtacgggt ctagggatgc tggtgcgaag tgtgcaagcc ggacccaggc tccgcattgc 1140 agggggggga tgatggagga cgtgatgggg cgcacggcgg gaatggaggc ggggtggggg 1200 aggggactgc ctggtgtcct tcgggccacg ctaatctcat tttcttctcc tgcagcctcg 1260 tcccgtagac aaacgtctca ggggacaccc aagctgtcta gagccgccac c 1311 <210> 668 <211> 1755 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 668 gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg 60 ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc 120 caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg 180 ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt 240 ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt 300 ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt 360 caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg 420 gtgactagta aatcaacggg actctctctt tttttttttt tttttttttt tttttccaaa 480 aggaggggag agggggtaaa aaaatgctgc actgtgcggc taggccggtg agtgagcggc 540 gcggagccaa tcagcgctcg ccgttccgaa agttgccttt tatggctcga gtggccgctg 600 tggcgtccta taaaacccgg cggcgcaacg cgcagccact gtcgagtccg cgtccacccg 660 cgagcacagg cctttcgcag ctctttcttc gccgctccac acccgccacc aggtaagcag 720 ggacaacagg cccagccggc cacagccctc ccgtgggcag tgaccgcgct gcagggtcgc 780 gggggacact cggcgcggac accggggaag gctggagggt ggtgccgggc cgcggagcgg 840 acactttcag atccaacttt cagtccaggg tgtagaccct ttacagccgc attgccacgg 900 tgtagacacc ggtggacccg ctctggctca gagcacgcgg cttgggggaa cccattaggg 960 tcgcagtgtg ggcgctatga gagccgatgc agctttcggg tgttgaaccg tatctgccca 1020 ccttgggggg aggacacaag gtcgggagcc aaacgccacg atcatgcctt ggtggcccat 1080 gggtctttgt ctaaaccggt ttgcccattt ggcttgccgg gcgggcgggc gcggcgggcc 1140 cggctcggcc gggtgggggc tgggttgcca ctgcgcttgc gcgctctatg gctgggtatt 1200 ggggcgcgtg cacgctgggg agggagccct tcctcttccc cctctcccaa gttaaacttg 1260 cgcgtgcgta ttgagacttg gagcgcggcc accggggttg ggcgagggcg gggccgttgt 1320 ccggaagggg cggggtcgca gaggattcgg ggcgcctgct cgcgcttcct gctgggtgtg 1380 gtcgcctccc gcgcgcgcac tagaccgccc ggcggggggg cgaaggcggg tcttgcgccc 1440 gtttggggag ggggcggaca cctggcttcc tgccgtgggg ccgcctccgg accagcgttt 1500 gcctcttatg gtaataacgc ggccggcctg ggcttcattt gtcccctgag tttgggcgcg 1560 cgccccctgg cggcccgtga ccgcggcttg ccggaagtgg gcagggcggc aacggctgcg 1620 cctagtggcc cgccagtgac cgcgaccctc ttttgtgccc tgatatagtt cgccagcctc 1680 tgctaaccat gttcatgcct tcttcttttt cctacagcgt ctcaggggac acccaagctg 1740 tctagagccg ccacc 1755 <210> 669 <211> 1547 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 669 tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg tcaatagggg 60 tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg actttccatt 120 gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt cccattattg 180 gcacgtacat aaggtcaata ggggtgagtc attgggtttt tccagccaat ttataaaacg 240 ccatgtactt tcccaccatt gacgtcaatg ggctattgaa actaatgcaa cgtgaccttt 300 aaacggtact ttcccatagc tgattaatgg gaaagtaccg ttctcgagcc aatacacgtc 360 aatgggaagt gaaagggcag ccaaaacgta acaccgcccc ggttttcccc tggaaattcc 420 atattggcac gcattctatt ggctgagctg cgttctacgt gggtataaga ggcgcgacca 480 gcgtcggtac cgtcgcagtc ttgggtctga ccaccgtaga acgcagagcc tttttcgcaa 540 cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt 600 tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctccagt acgtgattct 660 tgatcccgag ctggagccag gggcgggcct tgcgctttag gagccccttc gcctcgtgct 720 tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc 780 gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg acgtgctgcg 840 acgctttttt tctggcaaga tagtcttgta aatgcgggcc aggatctgca cactggtatt 900 tcggtttttg ggcccgcggc cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg 960 aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg 1020 cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg 1080 gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctccaggg 1140 ggctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg 1200 aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg 1260 tccaggcacc tcgattagtt ctggagcttt tggagtacgt cgtctttagg ttggggggag 1320 gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct 1380 tggcacttga tgtaattctc cttggaattt ggcctttttg agtttggatc ttggttcatt 1440 ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaacacgt 1500 ctcaggggtc gtctcagggg acacccaagc tgtctagagc cgccacc 1547 <210> 670 <211> 1797 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 670 gagtcaatgg gaaaaaccca ttggagccaa gtacactgac tcaataggga ctttccattg 60 ggttttgccc agtacataag gtcaataggg ggtgagtcaa caggaaagtc ccattggagc 120 caagtacatt gagtcaatag ggactttcca atgggttttg cccagtacat aaggtcaatg 180 ggaggtaagc caatgggttt ttcccattac tgacatgtat actgagtcat tagggacttt 240 ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga aagtcccatt 300 ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag tacaaaaggt 360 caataggggg tgagtcaatg ggtttttccc attattggca catacataag gtcaataggg 420 gtgactagta aatcaacggg acctcttcat cctcttcctc aatctcgctt tctctctcgc 480 tttttttttt ttcttcttct tttttttttt ttttttcaaa aggaggggag agggggtaaa 540 aaaatgctgc actgtgcggc gaggccggtg agtgagcgac gcggagccaa tcagcgcccg 600 ccgttccgaa agttgccttt tatggctcga gtggccgctg tggcgtccta taaaacccgg 660 cggcgcaacg cgcagccact gtcgagtcgc gtccacccgc gagcacagct tctttgcagc 720 tccttcgttg ccggtccaca cccgccacca ggtaagcagg gacgccgggc ccagcgggcc 780 ttcgctctct cgtggctagt acctcactgc agggtcctga ggatcactca gaacggacac 840 catgggcggg tggagggtgg tgccgggccg cggagcggac actggcacag ccaactttac 900 gcctagcgtg tagactcttt gcagccacat tcccgcggtg tagacactcg tgggcccgct 960 cccgctcggt gcgtggggct tggggacaca ctagggtcgc ggtgtgggca tttgatgagc 1020 cggtgcggct tgcgggtgtt aaaagccgta ttaggtccat cttgagagta cacagtattg 1080 ggaaccagac gctacgatca cgcctcaatg gcctctgggt ctttgtccaa accggtttgc 1140 ctattcggct tgccgggcgg gcgggcgggc gggcgggcgc ggcagggccg gctcggccgg 1200 gtgggggctg ggatgccact gcgcgtgcgc tctctatcac tgggcatcga ggcgcgtgtg 1260 cgctagggag ggacctcttc ctctccccct cttcctagtt agctgcgcgt gcgtattgag 1320 gctgggagcg cggctgcccg gggttgggcg agggcggggc cgttgtccgg aaggggcggg 1380 gtcacagtgg cacgggcgcc ttgtttgcgc ttcctgctgg gtgtggtcgc ctcccgcgcg 1440 cgcacaagcc gcccgtcggc gcagtgtagg cggagcttgc gcccgtttgg ggagggggcg 1500 gaggtctggc ttcctgccct aggtccgcct ccgggccagc gtttgccttt tatggtaata 1560 atgcggccgg tctgcgcttc ctttgtcccc tgagcttggg cgcgcgcccc ctggcggctc 1620 gagcccgcgg cttgccggaa gtgggcaggg cggcagcggc tgctcttggc ggccccgagg 1680 tgactatagc cttcttttgt gtcttgatag ttcgccagcc tctgctaacc atgttcatgc 1740 cttcttcttt ttcctacagc gtctcagggg acacccaagc tgtctagagc cgccacc 1797 <210> 671 <211> 769 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 671 attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat 60 atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg 120 acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt 180 tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag 240 tgtatcatat gccaagtccg ccccctattg acgtcaatga cggtaaatgg cccgcctggc 300 attatgccca gtacatgacc ttacgggact ttcctacttg gcagtacatc tacgtattag 360 tcatcgctat taccatggtg atgcggtttt ggcagtacac caatgggcgt ggatagcggt 420 ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc 480 accaaaatca acgggacttt ccaaaatgtc gtaataaccc cgccccgttg acgcaaatgg 540 gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga 600 tcgcctggag actccatcca cgctgttttg acctccatag aagataccgg gaccgatcca 660 gcctccgcgg ccgggaacgg tgcattggaa cgcggattcc ccgtgccaag agtgactcac 720 cgtccttgac acggccgcgg ggacacccaa gctgtctaga gccgccacc 769 <210> 672 <211> 904 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 672 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgg tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540 agaggccatc cacgctgttt tgacctccat agtggacacc gggaccgatc cagcctccgc 600 ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca agagtgaccc tggcagaact 660 cggtaagtct gttgacatgt atgtgatgta tactaacctg catgggacgt ggatttactt 720 gtgtatgtca gatagagtaa agattaactc ttgcatgtga gcggggcatc gagatagcga 780 taaatgagtc aggaggacgg atacttatat gtgttgttat cctcctctac agtcaaacag 840 attaagagct tccttcttct ttttcctaga agctcagaat aaacgctcaa ctttggccgc 900 cacc 904 <210> 673 <211> 1544 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 673 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgg tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540 agaggcctgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct 600 ttacgggtta tggcccttgc gtgccttgaa ttacttccac ctggctccag tacgtgattc 660 ttgatcccga gctggagcca ggggcgggcc ttgcgcttta ggagcccctt cgcctcgtgc 720 ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg 780 cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacgtgctgc 840 gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caggatctgc acactggtat 900 ttcggttttt gggcccgcgg ccggcgacgg ggcccgtgcg tcccagcgca catgttcggc 960 gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg 1020 gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct 1080 ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctccagg 1140 gggctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag 1200 gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt accgggcgcc 1260 gtccaggcac ctcgattagt tctggagctt ttggagtacg tcgtctttag gttgggggga 1320 ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc 1380 ttggcacttg atgtaattct ccttggaatt tggccttttt gagtttggat cttggttcat 1440 tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcagagct tccttcttct 1500 ttttcctaga agctcagaat aaacgctcaa ctttggccgc cacc 1544 <210> 674 <211> 1568 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 674 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgg tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540 agaggccgcc gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg 600 gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat 660 tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt 720 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta 780 ctccggccgc actctggtct tttttttttt tgttgttgtt gccctgctgc cttcgattgc 840 cgttcagcaa taggggctaa caaagggagg gtgcggggct tgctcgcccg gagcccggag 900 aggtcatggt tggggaggaa tggagggaca ggagtggcgg ctggggcccg cccgccttcg 960 gagcacatgt ccgacgccac ctggatgggg cgaggcctgg ggtttttccc gaagcaacca 1020 ggctggggtt agcgtgccga ggccatgtgg ccccagcacc cggcacgatc tggcttggcg 1080 gcgccgcgtt gccctgcctc cctaactagg gtgaggccat cccgtccggc accagttgcg 1140 tgcgtggaaa gatggccgct cccgggccct gttgcaagga gctcaaaatg gaggacgcgg 1200 cagcccggtg gagcgggcgg gtgagtcacc cacacaaagg aagagggcct ggtccctcac 1260 cggctgctgc ttcctgtgac cccgtggtcc tatcggccgc aatagtcacc tcgggctttt 1320 gagcacggct agtcgcggcg gggggagggg atgtaatggc gttggagttt gttcacattt 1380 ggtgggtgga gactagtcag gccagcctgg cgctggaagt catttttgga atttgtcccc 1440 ttgagttttg agcggagcta attctcgggc ttcttagcgg ttcaaaggta tcttttaaac 1500 ccttttttag agcttccttc ttctttttcc tagaagctca gaataaacgc tcaactttgg 1560 ccgccacc 1568 <210> 675 <211> 1190 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 675 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgg tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540 agaggccatc cacgctgttt tgacctccat agtggacacc gggaccgatc cagcctccgc 600 ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca agagtgactc agatcctcac 660 tctcttccgc atcgctgtct gcgagggcca gctgttgggc tcgcggttga ggacaaactc 720 ttcgcggtct ttccagtact cttggatcgg aaacccgtcg gcctccgaac ggtactccgc 780 caccgaggga cctgagcgag tccgcatcga ccggatcgga aaacctctcg agaaaggcgt 840 ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc gggcggcagc gggtggcggt 900 cggggttgtt tctggcggag gtgctgctga tgatgtaatt aaagtaggcg gtcttgagac 960 ggcggatggt cgaggtgagg tgtggcaggc ttgagatcca gctgttgggg tgagtactcc 1020 ctctcaaaag cgggcattac ttctgcgcta agattgtcag tttccaaaaa cgaggaggat 1080 ttgatattca cctggcccga tctggccata cacttgagtg acaatgacat ccactttgcc 1140 tttctctcca caggtgtcca ctcccaggtc caagtttaaa cgccgccacc 1190 <210> 676 <211> 922 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 676 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 360 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 420 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 480 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 540 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta ccgtcgcagt 600 cttgggtctg accaccgtag aacgcagagc tcctcgctgc agtatcctgc ccaagaaaga 660 gcgacccctg gcagaactcg gtaagtctgt tgacatgtat gtgatgtata ctaacctgca 720 tgggacgtgg atttacttgt gtatgtcaga tagagtaaag attaactctt gcatgtgagc 780 ggggcatcga gatagcgata aatgagtcag gaggacggat acttatatgt gttgttatcc 840 tcctctacag tcaaacagat taagagcttc cttcttcttt ttcctagaag ctcagaataa 900 acgctcaact ttggccgcca cc 922 <210> 677 <211> 1610 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 677 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 360 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 420 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 480 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 540 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta ccgtcgcagt 600 cttgggtctg acctgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg 660 gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctccagtacg 720 tgattcttga tcccgagctg gagccagggg cgggccttgc gctttaggag ccccttcgcc 780 tcgtgcttga gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca 840 ccttcgcgcc tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacg 900 tgctgcgacg ctttttttct ggcaagatag tcttgtaaat gcgggccagg atctgcacac 960 tggtatttcg gtttttgggc ccgcggccgg cgacggggcc cgtgcgtccc agcgcacatg 1020 ttcggcgagg cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc 1080 tggccggcct gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc 1140 aaggctggcc cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc 1200 tccagggggc tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac 1260 acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca tgtgactcca cggagtaccg 1320 ggcgccgtcc aggcacctcg attagttctg gagcttttgg agtacgtcgt ctttaggttg 1380 gggggagggg ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag 1440 gccagcttgg cacttgatgt aattctcctt ggaatttggc ctttttgagt ttggatcttg 1500 gttcattctc aagcctcaga cagtggttca aagttttttt cttccatttc agagcttcct 1560 tcttcttttt cctagaagct cagaataaac gctcaacttt ggccgccacc 1610 <210> 678 <211> 1208 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 678 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 360 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 420 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 480 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 540 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta ccgtcgcagt 600 cttgggtctg accaccgtag aacgcagagc tcctcgctgc agtatcctgc ccaagaaaga 660 gcgacctcag atcctcactc tcttccgcat cgctgtctgc gagggccagc tgttgggctc 720 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 780 ctccgaacgg tactccgcca ccgagggacc tgagcgagtc cgcatcgacc ggatcggaaa 840 acctctcgag aaaggcgtct aaccagtcac agtcgcaagg taggctgagc accgtggcgg 900 gcggcagcgg gtggcggtcg gggttgtttc tggcggaggt gctgctgatg atgtaattaa 960 agtaggcggt cttgagacgg cggatggtcg aggtgaggtg tggcaggctt gagatccagc 1020 tgttggggtg agtactccct ctcaaaagcg ggcattactt ctgcgctaag attgtcagtt 1080 tccaaaaacg aggaggattt gatattcacc tggcccgatc tggccataca cttgagtgac 1140 aatgacatcc actttgcctt tctctccaca ggtgtccact cccaggtcca agtttaaacg 1200 ccgccacc 1208 <210> 679 <211> 1488 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 679 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccagca catcgcccac agtccccgag aagttgggag gggtcggcaa ttgaaccggt 360 gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt 420 tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt 480 cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc 540 ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct ccagtacgtg 600 attcttgatc ccgagctgga gccaggggcg ggccttgcgc tttaggagcc ccttcgcctc 660 gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc 720 ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacgtg 780 ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaggat ctgcacactg 840 gtatttcggt ttttgggccc gcggccggcg acggggcccg tgcgtcccag cgcacatgtt 900 cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg 960 gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa 1020 ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctc 1080 cagggggctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac 1140 aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg 1200 cgccgtccag gcacctcgat tagttctgga gcttttggag tacgtcgtct ttaggttggg 1260 gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc 1320 cagcttggca cttgatgtaa ttctccttgg aatttggcct ttttgagttt ggatcttggt 1380 tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag agcttccttc 1440 ttctttttcc tagaagctca gaataaacgc tcaactttgg ccgccacc 1488 <210> 680 <211> 1513 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 680 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccagca catcgcccac agtccccgag aagttgggag gggtcggcaa ttgaaccggt 360 gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt 420 tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt 480 cgcaacgggt ttgccgccag aacacaggtg aggggcgggt gtggcttccg cgggccgccg 540 agctggaggt cctgctccga gcgggccggg ccccgctgtc gtcggcgggg attagctgcg 600 agcattcccg cttcgagttg cgggcggcgc gggaggcaga gtgcgaggcc tagcggcaac 660 cccgtagcct cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgcgc cgccgccgcg 720 tgctactccg gccgcactct ggtctttttt ttttttgttg ttgttgccct gctgccttcg 780 attgccgttc agcaataggg gctaacaaag ggagggtgcg gggcttgctc gcccggagcc 840 cggagaggtc atggttgggg aggaatggag ggacaggagt ggcggctggg gcccgcccgc 900 cttcggagca catgtccgac gccacctgga tggggcgagg cctggggttt ttcccgaagc 960 aaccaggctg gggttagcgt gccgaggcca tgtggcccca gcacccggca cgatctggct 1020 tggcggcgcc gcgttgccct gcctccctaa ctagggtgag gccatcccgt ccggcaccag 1080 ttgcgtgcgt ggaaagatgg ccgctcccgg gccctgttgc aaggagctca aaatggagga 1140 cgcggcagcc cggtggagcg ggcgggtgag tcacccacac aaaggaagag ggcctggtcc 1200 ctcaccggct gctgcttcct gtgaccccgt ggtcctatcg gccgcaatag tcacctcggg 1260 cttttgagca cggctagtcg cggcgggggg aggggatgta atggcgttgg agtttgttca 1320 catttggtgg gtggagacta gtcaggccag cctggcgctg gaagtcattt ttggaatttg 1380 tccccttgag ttttgagcgg agctaattct cgggcttctt agcggttcaa aggtatcttt 1440 taaacccttt tttagagctt ccttcttctt tttcctagaa gctcagaata aacgctcaac 1500 tttggccgcc acc 1513 <210> 681 <211> 1049 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 681 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccagca catcgcccac agtccccgag aagttgggag gggtcggcaa ttgaaccggt 360 gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt 420 tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt 480 cgcaacgggt ttgccgccag aacacagtca gatcctcact ctcttccgca tcgctgtctg 540 cgagggccag ctgttgggct cgcggttgag gacaaactct tcgcggtctt tccagtactc 600 ttggatcgga aacccgtcgg cctccgaacg gtactccgcc accgagggac ctgagcgagt 660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 720 gtaggctgag caccgtggcg ggcggcagcg ggtggcggtc ggggttgttt ctggcggagg 780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gaggtgaggt 840 gtggcaggct tgagatccag ctgttggggt gagtactccc tctcaaaagc gggcattact 900 tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt tgatattcac ctggcccgat 960 ctggccatac acttgagtga caatgacatc cactttgcct ttctctccac aggtgtccac 1020 tcccaggtcc aagtttaaac gccgccacc 1049 <210> 682 <211> 1036 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 682 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagc ggggctgacg tcgggaggtg gcctccgtgg gaagggacac ccggatcttg 360 acacagcctt ggcagcggag taaggaagag tagggataga ttctggccgc cctcttggcc 420 agcttctcgc cgccccaccc tccgctaggg ccaagagtaa ttcatacaaa aggagggatc 480 gccttcgcaa ggggagagcc cagggaccgt ccctaaattc tcacagaccc aaatccctgt 540 agccgcccca cgacagcgcg aggagcatgc gctcagggct gagcgcgggg agagcagagc 600 acacaagctc atagaccctg gtcgtggggg ggaggaccgg ggagctggcg cggggcaaac 660 tgggaaagcg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg agaacggtat 720 ataagtgcgg cagtcgcctt ggacgttctt tttcgcaacg ggtttgccgt cagaacgcag 780 cctggcagaa ctcggtaagt ctgttgacat gtatgtgatg tatactaacc tgcatgggac 840 gtggatttac ttgtgtatgt cagatagagt aaagattaac tcttgcatgt gagcggggca 900 tcgagatagc gataaatgag tcaggaggac ggatacttat atgtgttgtt atcctcctct 960 acagtcaaac agattaagag cttccttctt ctttttccta gaagctcaga ataaacgctc 1020 aactttggcc gccacc 1036 <210> 683 <211> 1786 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 683 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagc ggggctgacg tcgggaggtg gcctccgtgg gaagggacac ccggatcttg 360 acacagcctt ggcagcggag taaggaagag tagggataga ttctggccgc cctcttggcc 420 agcttctcgc cgccccaccc tccgctaggg ccaagagtaa ttcatacaaa aggagggatc 480 gccttcgcaa ggggagagcc cagggaccgt ccctaaattc tcacagaccc aaatccctgt 540 agccgcccca cgacagcgcg aggagcatgc gctcagggct gagcgcgggg agagcagagc 600 acacaagctc atagaccctg gtcgtggggg ggaggaccgg ggagctggcg cggggcaaac 660 tgggaaagcg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg agaacggtat 720 ataagtgcgg cagtcgcctt ggacgttctt tttcgcaacg ggtttgccgt cagaacgcag 780 gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc 840 gggccccgct gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg 900 cgcgggaggc agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt 960 gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt 1020 tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata ggggctaaca 1080 aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg gggaggaatg 1140 gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc gacgccacct 1200 ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag cgtgccgagg 1260 ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc cctgcctccc 1320 taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc 1380 cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt 1440 gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt cctgtgaccc 1500 cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag tcgcggcggg 1560 gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga ctagtcaggc 1620 cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag cggagctaat 1680 tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttagag cttccttctt 1740 ctttttccta gaagctcaga ataaacgctc aactttggcc gccacc 1786 <210> 684 <211> 810 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 684 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgtggtgat gcggttttgg cagtacacca 240 atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 300 atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg 360 ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc 420 gtttagtgaa ccgtcagatc gcctggagag gccatccacg ctgttttgac ctccatagtg 480 gacaccggga ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc 540 gtgccaagag tgaccctggc agaactcggt aagtctgttg acatgtatgt gatgtatact 600 aacctgcatg ggacgtggat ttacttgtgt atgtcagata gagtaaagat taactcttgc 660 atgtgagcgg ggcatcgaga tagcgataaa tgagtcagga ggacggatac ttatatgtgt 720 tgttatcctc ctctacagtc aaacagatta agagcttcct tcttcttttt cctagaagct 780 cagaataaac gctcaacttt ggccgccacc 810 <210> 685 <211> 1450 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 685 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgtggtgat gcggttttgg cagtacacca 240 atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 300 atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg 360 ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc 420 gtttagtgaa ccgtcagatc gcctggagag gcctgccgcc agaacacagg taagtgccgt 480 gtgtggttcc cgcgggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac 540 ttccacctgg ctccagtacg tgattcttga tcccgagctg gagccagggg cgggccttgc 600 gctttaggag ccccttcgcc tcgtgcttga gttgaggcct ggcctgggcg ctggggccgc 660 cgcgtgcgaa tctggtggca ccttcgcgcc tgtctcgctg ctttcgataa gtctctagcc 720 atttaaaatt tttgatgacg tgctgcgacg ctttttttct ggcaagatag tcttgtaaat 780 gcgggccagg atctgcacac tggtatttcg gtttttgggc ccgcggccgg cgacggggcc 840 cgtgcgtccc agcgcacatg ttcggcgagg cggggcctgc gagcgcggcc accgagaatc 900 ggacgggggt agtctcaagc tggccggcct gctctggtgc ctggcctcgc gccgccgtgt 960 atcgccccgc cctgggcggc aaggctggcc cggtcggcac cagttgcgtg agcggaaaga 1020 tggccgcttc ccggccctgc tccagggggc tcaaaatgga ggacgcggcg ctcgggagag 1080 cgggcgggtg agtcacccac acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca 1140 tgtgactcca cggagtaccg ggcgccgtcc aggcacctcg attagttctg gagcttttgg 1200 agtacgtcgt ctttaggttg gggggagggg ttttatgcga tggagtttcc ccacactgag 1260 tgggtggaga ctgaagttag gccagcttgg cacttgatgt aattctcctt ggaatttggc 1320 ctttttgagt ttggatcttg gttcattctc aagcctcaga cagtggttca aagttttttt 1380 cttccatttc agagcttcct tcttcttttt cctagaagct cagaataaac gctcaacttt 1440 ggccgccacc 1450 <210> 686 <211> 1474 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 686 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgtggtgat gcggttttgg cagtacacca 240 atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 300 atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg 360 ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc 420 gtttagtgaa ccgtcagatc gcctggagag gccgccgtca gaacgcaggt gaggggcggg 480 tgtggcttcc gcgggccgcc gagctggagg tcctgctccg agcgggccgg gccccgctgt 540 cgtcggcggg gattagctgc gagcattccc gcttcgagtt gcgggcggcg cgggaggcag 600 agtgcgaggc ctagcggcaa ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt 660 ggtgtccgcg ccgccgccgc gtgctactcc ggccgcactc tggtcttttt tttttttgtt 720 gttgttgccc tgctgccttc gattgccgtt cagcaatagg ggctaacaaa gggagggtgc 780 ggggcttgct cgcccggagc ccggagaggt catggttggg gaggaatgga gggacaggag 840 tggcggctgg ggcccgcccg ccttcggagc acatgtccga cgccacctgg atggggcgag 900 gcctggggtt tttcccgaag caaccaggct ggggttagcg tgccgaggcc atgtggcccc 960 agcacccggc acgatctggc ttggcggcgc cgcgttgccc tgcctcccta actagggtga 1020 ggccatcccg tccggcacca gttgcgtgcg tggaaagatg gccgctcccg ggccctgttg 1080 caaggagctc aaaatggagg acgcggcagc ccggtggagc gggcgggtga gtcacccaca 1140 caaaggaaga gggcctggtc cctcaccggc tgctgcttcc tgtgaccccg tggtcctatc 1200 ggccgcaata gtcacctcgg gcttttgagc acggctagtc gcggcggggg gaggggatgt 1260 aatggcgttg gagtttgttc acatttggtg ggtggagact agtcaggcca gcctggcgct 1320 ggaagtcatt tttggaattt gtccccttga gttttgagcg gagctaattc tcgggcttct 1380 tagcggttca aaggtatctt ttaaaccctt ttttagagct tccttcttct ttttcctaga 1440 agctcagaat aaacgctcaa ctttggccgc cacc 1474 <210> 687 <211> 1096 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 687 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgtggtgat gcggttttgg cagtacacca 240 atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 300 atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg 360 ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc 420 gtttagtgaa ccgtcagatc gcctggagag gccatccacg ctgttttgac ctccatagtg 480 gacaccggga ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc 540 gtgccaagag tgactcagat cctcactctc ttccgcatcg ctgtctgcga gggccagctg 600 ttgggctcgc ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac 660 ccgtcggcct ccgaacggta ctccgccacc gagggacctg agcgagtccg catcgaccgg 720 atcggaaaac ctctcgagaa aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac 780 cgtggcgggc ggcagcgggt ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat 840 gtaattaaag taggcggtct tgagacggcg gatggtcgag gtgaggtgtg gcaggcttga 900 gatccagctg ttggggtgag tactccctct caaaagcggg cattacttct gcgctaagat 960 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgatctg gccatacact 1020 tgagtgacaa tgacatccac tttgcctttc tctccacagg tgtccactcc caggtccaag 1080 tttaaacgcc gccacc 1096 <210> 688 <211> 828 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 688 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta 240 taaaacgcca tgtactttcc caccattgac gtcaatgggc tattgaaact aatgcaacgt 300 gacctttaaa cggtactttc ccatagctga ttaatgggaa agtaccgttc tcgagccaat 360 acacgtcaat gggaagtgaa agggcagcca aaacgtaaca ccgccccggt tttcccctgg 420 aaattccata ttggcacgca ttctattggc tgagctgcgt tctacgtggg tataagaggc 480 gcgaccagcg tcggtaccgt cgcagtcttg ggtctgacca ccgtagaacg cagagctcct 540 cgctgcagta tcctgcccaa gaaagagcga cccctggcag aactcggtaa gtctgttgac 600 atgtatgtga tgtatactaa cctgcatggg acgtggattt acttgtgtat gtcagataga 660 gtaaagatta actcttgcat gtgagcgggg catcgagata gcgataaatg agtcaggagg 720 acggatactt atatgtgttg ttatcctcct ctacagtcaa acagattaag agcttccttc 780 ttctttttcc tagaagctca gaataaacgc tcaactttgg ccgccacc 828 <210> 689 <211> 1540 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 689 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta 240 taaaacgcca tgtactttcc caccattgac gtcaatgggc tattgaaact aatgcaacgt 300 gacctttaaa cggtactttc ccatagctga ttaatgggaa agtaccgttc tcgagccaat 360 acacgtcaat gggaagtgaa agggcagcca aaacgtaaca ccgccccggt tttcccctgg 420 aaattccata ttggcacgca ttctattggc tgagctgcgt tctacgtggg tataagaggc 480 gcgaccagcg tcggtaccgt cgcagtcttg ggtctgaccg ccgtcagaac gcaggtgagg 540 ggcgggtgtg gcttccgcgg gccgccgagc tggaggtcct gctccgagcg ggccgggccc 600 cgctgtcgtc ggcggggatt agctgcgagc attcccgctt cgagttgcgg gcggcgcggg 660 aggcagagtg cgaggcctag cggcaacccc gtagcctcgc ctcgtgtccg gcttgaggcc 720 tagcgtggtg tccgcgccgc cgccgcgtgc tactccggcc gcactctggt cttttttttt 780 tttgttgttg ttgccctgct gccttcgatt gccgttcagc aataggggct aacaaaggga 840 gggtgcgggg cttgctcgcc cggagcccgg agaggtcatg gttggggagg aatggaggga 900 caggagtggc ggctggggcc cgcccgcctt cggagcacat gtccgacgcc acctggatgg 960 ggcgaggcct ggggtttttc ccgaagcaac caggctgggg ttagcgtgcc gaggccatgt 1020 ggccccagca cccggcacga tctggcttgg cggcgccgcg ttgccctgcc tccctaacta 1080 gggtgaggcc atcccgtccg gcaccagttg cgtgcgtgga aagatggccg ctcccgggcc 1140 ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg tggagcgggc gggtgagtca 1200 cccacacaaa ggaagagggc ctggtccctc accggctgct gcttcctgtg accccgtggt 1260 cctatcggcc gcaatagtca cctcgggctt ttgagcacgg ctagtcgcgg cggggggagg 1320 ggatgtaatg gcgttggagt ttgttcacat ttggtgggtg gagactagtc aggccagcct 1380 ggcgctggaa gtcatttttg gaatttgtcc ccttgagttt tgagcggagc taattctcgg 1440 gcttcttagc ggttcaaagg tatcttttaa accctttttt agagcttcct tcttcttttt 1500 cctagaagct cagaataaac gctcaacttt ggccgccacc 1540 <210> 690 <211> 1114 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 690 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta 240 taaaacgcca tgtactttcc caccattgac gtcaatgggc tattgaaact aatgcaacgt 300 gacctttaaa cggtactttc ccatagctga ttaatgggaa agtaccgttc tcgagccaat 360 acacgtcaat gggaagtgaa agggcagcca aaacgtaaca ccgccccggt tttcccctgg 420 aaattccata ttggcacgca ttctattggc tgagctgcgt tctacgtggg tataagaggc 480 gcgaccagcg tcggtaccgt cgcagtcttg ggtctgacca ccgtagaacg cagagctcct 540 cgctgcagta tcctgcccaa gaaagagcga cctcagatcc tcactctctt ccgcatcgct 600 gtctgcgagg gccagctgtt gggctcgcgg ttgaggacaa actcttcgcg gtctttccag 660 tactcttgga tcggaaaccc gtcggcctcc gaacggtact ccgccaccga gggacctgag 720 cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc 780 gcaaggtagg ctgagcaccg tggcgggcgg cagcgggtgg cggtcggggt tgtttctggc 840 ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga tggtcgaggt 900 gaggtgtggc aggcttgaga tccagctgtt ggggtgagta ctccctctca aaagcgggca 960 ttacttctgc gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc 1020 ccgatctggc catacacttg agtgacaatg acatccactt tgcctttctc tccacaggtg 1080 tccactccca ggtccaagtt taaacgccgc cacc 1114 <210> 691 <211> 669 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 691 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtggcacatc gcccacagtc cccgagaagt 240 tgggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa 300 gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg 360 cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca cagcctggca 420 gaactcggta agtctgttga catgtatgtg atgtatacta acctgcatgg gacgtggatt 480 tacttgtgta tgtcagatag agtaaagatt aactcttgca tgtgagcggg gcatcgagat 540 agcgataaat gagtcaggag gacggatact tatatgtgtt gttatcctcc tctacagtca 600 aacagattaa gagcttcctt cttctttttc ctagaagctc agaataaacg ctcaactttg 660 gccgccacc 669 <210> 692 <211> 1394 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 692 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtggcacatc gcccacagtc cccgagaagt 240 tgggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa 300 gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg 360 cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca caggtaagtg 420 ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc gtgccttgaa 480 ttacttccac ctggctccag tacgtgattc ttgatcccga gctggagcca ggggcgggcc 540 ttgcgcttta ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg 600 ccgccgcgtg cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct 660 agccatttaa aatttttgat gacgtgctgc gacgcttttt ttctggcaag atagtcttgt 720 aaatgcgggc caggatctgc acactggtat ttcggttttt gggcccgcgg ccggcgacgg 780 ggcccgtgcg tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag 840 aatcggacgg gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc 900 gtgtatcgcc ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga 960 aagatggccg cttcccggcc ctgctccagg gggctcaaaa tggaggacgc ggcgctcggg 1020 agagcgggcg ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc 1080 ttcatgtgac tccacggagt accgggcgcc gtccaggcac ctcgattagt tctggagctt 1140 ttggagtacg tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac 1200 tgagtgggtg gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt 1260 tggccttttt gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt 1320 ttttcttcca tttcagagct tccttcttct ttttcctaga agctcagaat aaacgctcaa 1380 ctttggccgc cacc 1394 <210> 693 <211> 1419 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 693 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtggcacatc gcccacagtc cccgagaagt 240 tgggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa 300 gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg 360 cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca caggtgaggg 420 gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg ctccgagcgg gccgggcccc 480 gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc gagttgcggg cggcgcggga 540 ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct 600 agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg cactctggtc tttttttttt 660 ttgttgttgt tgccctgctg ccttcgattg ccgttcagca ataggggcta acaaagggag 720 ggtgcggggc ttgctcgccc ggagcccgga gaggtcatgg ttggggagga atggagggac 780 aggagtggcg gctggggccc gcccgccttc ggagcacatg tccgacgcca cctggatggg 840 gcgaggcctg gggtttttcc cgaagcaacc aggctggggt tagcgtgccg aggccatgtg 900 gccccagcac ccggcacgat ctggcttggc ggcgccgcgt tgccctgcct ccctaactag 960 ggtgaggcca tcccgtccgg caccagttgc gtgcgtggaa agatggccgc tcccgggccc 1020 tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac 1080 ccacacaaag gaagagggcc tggtccctca ccggctgctg cttcctgtga ccccgtggtc 1140 ctatcggccg caatagtcac ctcgggcttt tgagcacggc tagtcgcggc ggggggaggg 1200 gatgtaatgg cgttggagtt tgttcacatt tggtgggtgg agactagtca ggccagcctg 1260 gcgctggaag tcatttttgg aatttgtccc cttgagtttt gagcggagct aattctcggg 1320 cttcttagcg gttcaaaggt atcttttaaa ccctttttta gagcttcctt cttctttttc 1380 ctagaagctc agaataaacg ctcaactttg gccgccacc 1419 <210> 694 <211> 955 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 694 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtggcacatc gcccacagtc cccgagaagt 240 tgggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa 300 gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg 360 cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca cagtcagatc 420 ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca 480 aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac 540 tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa 600 ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg 660 gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt 720 gagacggcgg atggtcgagg tgaggtgtgg caggcttgag atccagctgt tggggtgagt 780 actccctctc aaaagcgggc attacttctg cgctaagatt gtcagtttcc aaaaacgagg 840 aggatttgat attcacctgg cccgatctgg ccatacactt gagtgacaat gacatccact 900 ttgcctttct ctccacaggt gtccactccc aggtccaagt ttaaacgccg ccacc 955 <210> 695 <211> 1667 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 695 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagcgggg ctgacgtcgg gaggtggcct 240 ccgtgggaag ggacacccgg atcttgacac agccttggca gcggagtaag gaagagtagg 300 gatagattct ggccgccctc ttggccagct tctcgccgcc ccaccctccg ctagggccaa 360 gagtaattca tacaaaagga gggatcgcct tcgcaagggg agagcccagg gaccgtccct 420 aaattctcac agacccaaat ccctgtagcc gccccacgac agcgcgagga gcatgcgctc 480 agggctgagc gcggggagag cagagcacac aagctcatag accctggtcg tgggggggag 540 gaccggggag ctggcgcggg gcaaactggg aaagcggtgt cgtgtgctgg ctccgccctc 600 ttcccgaggg tgggggagaa cggtatataa gtgcggcagt cgccttggac gttctttttc 660 gcaacgggtt tgccgtcaga acgcaggtaa gtgccgtgtg tggttcccgc gggcctggcc 720 tctttacggg ttatggccct tgcgtgcctt gaattacttc cacctggctc cagtacgtga 780 ttcttgatcc cgagctggag ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg 840 tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct 900 tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacgtgc 960 tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaggatc tgcacactgg 1020 tatttcggtt tttgggcccg cggccggcga cggggcccgt gcgtcccagc gcacatgttc 1080 ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg 1140 ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag 1200 gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc 1260 agggggctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca 1320 aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc 1380 gccgtccagg cacctcgatt agttctggag cttttggagt acgtcgtctt taggttgggg 1440 ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc 1500 agcttggcac ttgatgtaat tctccttgga atttggcctt tttgagtttg gatcttggtt 1560 cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcaga gcttccttct 1620 tctttttcct agaagctcag aataaacgct caactttggc cgccacc 1667 <210> 696 <211> 1692 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 696 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagcgggg ctgacgtcgg gaggtggcct 240 ccgtgggaag ggacacccgg atcttgacac agccttggca gcggagtaag gaagagtagg 300 gatagattct ggccgccctc ttggccagct tctcgccgcc ccaccctccg ctagggccaa 360 gagtaattca tacaaaagga gggatcgcct tcgcaagggg agagcccagg gaccgtccct 420 aaattctcac agacccaaat ccctgtagcc gccccacgac agcgcgagga gcatgcgctc 480 agggctgagc gcggggagag cagagcacac aagctcatag accctggtcg tgggggggag 540 gaccggggag ctggcgcggg gcaaactggg aaagcggtgt cgtgtgctgg ctccgccctc 600 ttcccgaggg tgggggagaa cggtatataa gtgcggcagt cgccttggac gttctttttc 660 gcaacgggtt tgccgtcaga acgcaggtga ggggcgggtg tggcttccgc gggccgccga 720 gctggaggtc ctgctccgag cgggccgggc cccgctgtcg tcggcgggga ttagctgcga 780 gcattcccgc ttcgagttgc gggcggcgcg ggaggcagag tgcgaggcct agcggcaacc 840 ccgtagcctc gcctcgtgtc cggcttgagg cctagcgtgg tgtccgcgcc gccgccgcgt 900 gctactccgg ccgcactctg gtcttttttt tttttgttgt tgttgccctg ctgccttcga 960 ttgccgttca gcaatagggg ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc 1020 ggagaggtca tggttgggga ggaatggagg gacaggagtg gcggctgggg cccgcccgcc 1080 ttcggagcac atgtccgacg ccacctggat ggggcgaggc ctggggtttt tcccgaagca 1140 accaggctgg ggttagcgtg ccgaggccat gtggccccag cacccggcac gatctggctt 1200 ggcggcgccg cgttgccctg cctccctaac tagggtgagg ccatcccgtc cggcaccagt 1260 tgcgtgcgtg gaaagatggc cgctcccggg ccctgttgca aggagctcaa aatggaggac 1320 gcggcagccc ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gcctggtccc 1380 tcaccggctg ctgcttcctg tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc 1440 ttttgagcac ggctagtcgc ggcgggggga ggggatgtaa tggcgttgga gtttgttcac 1500 atttggtggg tggagactag tcaggccagc ctggcgctgg aagtcatttt tggaatttgt 1560 ccccttgagt tttgagcgga gctaattctc gggcttctta gcggttcaaa ggtatctttt 1620 aaaccctttt ttagagcttc cttcttcttt ttcctagaag ctcagaataa acgctcaact 1680 ttggccgcca cc 1692 <210> 697 <211> 1228 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 697 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagcgggg ctgacgtcgg gaggtggcct 240 ccgtgggaag ggacacccgg atcttgacac agccttggca gcggagtaag gaagagtagg 300 gatagattct ggccgccctc ttggccagct tctcgccgcc ccaccctccg ctagggccaa 360 gagtaattca tacaaaagga gggatcgcct tcgcaagggg agagcccagg gaccgtccct 420 aaattctcac agacccaaat ccctgtagcc gccccacgac agcgcgagga gcatgcgctc 480 agggctgagc gcggggagag cagagcacac aagctcatag accctggtcg tgggggggag 540 gaccggggag ctggcgcggg gcaaactggg aaagcggtgt cgtgtgctgg ctccgccctc 600 ttcccgaggg tgggggagaa cggtatataa gtgcggcagt cgccttggac gttctttttc 660 gcaacgggtt tgccgtcaga acgcagtcag atcctcactc tcttccgcat cgctgtctgc 720 gagggccagc tgttgggctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 780 tggatcggaa acccgtcggc ctccgaacgg tactccgcca ccgagggacc tgagcgagtc 840 cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 900 taggctgagc accgtggcgg gcggcagcgg gtggcggtcg gggttgtttc tggcggaggt 960 gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg aggtgaggtg 1020 tggcaggctt gagatccagc tgttggggtg agtactccct ctcaaaagcg ggcattactt 1080 ctgcgctaag attgtcagtt tccaaaaacg aggaggattt gatattcacc tggcccgatc 1140 tggccataca cttgagtgac aatgacatcc actttgcctt tctctccaca ggtgtccact 1200 cccaggtcca agtttaaacg ccgccacc 1228 <210> 698 <211> 597 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 698 tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 240 atccacgctg ttttgacctc catagtggac accgggaccg atccagcctc cgcggccggg 300 aacggtgcat tggaacgcgg attccccgtg ccaagagtga ccctggcaga actcggtaag 360 tctgttgaca tgtatgtgat gtatactaac ctgcatggga cgtggattta cttgtgtatg 420 tcagatagag taaagattaa ctcttgcatg tgagcggggc atcgagatag cgataaatga 480 gtcaggagga cggatactta tatgtgttgt tatcctcctc tacagtcaaa cagattaaga 540 gcttccttct tctttttcct agaagctcag aataaacgct caactttggc cgccacc 597 <210> 699 <211> 1237 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 699 tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 240 tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg 300 ttatggccct tgcgtgcctt gaattacttc cacctggctc cagtacgtga ttcttgatcc 360 cgagctggag ccaggggcgg gccttgcgct ttaggagccc cttcgcctcg tgcttgagtt 420 gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt 480 ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacgtgc tgcgacgctt 540 tttttctggc aagatagtct tgtaaatgcg ggccaggatc tgcacactgg tatttcggtt 600 tttgggcccg cggccggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg 660 ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct 720 ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg 780 tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctcc agggggctca 840 aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg 900 gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg 960 cacctcgatt agttctggag cttttggagt acgtcgtctt taggttgggg ggaggggttt 1020 tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac 1080 ttgatgtaat tctccttgga atttggcctt tttgagtttg gatcttggtt cattctcaag 1140 cctcagacag tggttcaaag tttttttctt ccatttcaga gcttccttct tctttttcct 1200 agaagctcag aataaacgct caactttggc cgccacc 1237 <210> 700 <211> 1261 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 700 tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 240 gccgtcagaa cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc 300 tgctccgagc gggccgggcc ccgctgtcgt cggcggggat tagctgcgag cattcccgct 360 tcgagttgcg ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg 420 cctcgtgtcc ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc 480 cgcactctgg tctttttttt ttttgttgtt gttgccctgc tgccttcgat tgccgttcag 540 caataggggc taacaaaggg agggtgcggg gcttgctcgc ccggagcccg gagaggtcat 600 ggttggggag gaatggaggg acaggagtgg cggctggggc ccgcccgcct tcggagcaca 660 tgtccgacgc cacctggatg gggcgaggcc tggggttttt cccgaagcaa ccaggctggg 720 gttagcgtgc cgaggccatg tggccccagc acccggcacg atctggcttg gcggcgccgc 780 gttgccctgc ctccctaact agggtgaggc catcccgtcc ggcaccagtt gcgtgcgtgg 840 aaagatggcc gctcccgggc cctgttgcaa ggagctcaaa atggaggacg cggcagcccg 900 gtggagcggg cgggtgagtc acccacacaa aggaagaggg cctggtccct caccggctgc 960 tgcttcctgt gaccccgtgg tcctatcggc cgcaatagtc acctcgggct tttgagcacg 1020 gctagtcgcg gcggggggag gggatgtaat ggcgttggag tttgttcaca tttggtgggt 1080 ggagactagt caggccagcc tggcgctgga agtcattttt ggaatttgtc cccttgagtt 1140 ttgagcggag ctaattctcg ggcttcttag cggttcaaag gtatctttta aacccttttt 1200 tagagcttcc ttcttctttt tcctagaagc tcagaataaa cgctcaactt tggccgccac 1260 c 1261 <210> 701 <211> 883 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 701 tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat 60 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 120 actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac 180 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagaggcc 240 atccacgctg ttttgacctc catagtggac accgggaccg atccagcctc cgcggccggg 300 aacggtgcat tggaacgcgg attccccgtg ccaagagtga ctcagatcct cactctcttc 360 cgcatcgctg tctgcgaggg ccagctgttg ggctcgcggt tgaggacaaa ctcttcgcgg 420 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtactc cgccaccgag 480 ggacctgagc gagtccgcat cgaccggatc ggaaaacctc tcgagaaagg cgtctaacca 540 gtcacagtcg caaggtaggc tgagcaccgt ggcgggcggc agcgggtggc ggtcggggtt 600 gtttctggcg gaggtgctgc tgatgatgta attaaagtag gcggtcttga gacggcggat 660 ggtcgaggtg aggtgtggca ggcttgagat ccagctgttg gggtgagtac tccctctcaa 720 aagcgggcat tacttctgcg ctaagattgt cagtttccaa aaacgaggag gatttgatat 780 tcacctggcc cgatctggcc atacacttga gtgacaatga catccacttt gcctttctct 840 ccacaggtgt ccactcccag gtccaagttt aaacgccgcc acc 883 <210> 702 <211> 1303 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 702 agtcattggg tttttccagc caatttataa aacgccatgt actttcccac cattgacgtc 60 aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca tagctgatta 120 atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg gcagccaaaa 180 cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc tattggctga 240 gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc agtcttgggt 300 ctgacctgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt 360 tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctccagt acgtgattct 420 tgatcccgag ctggagccag gggcgggcct tgcgctttag gagccccttc gcctcgtgct 480 tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc 540 gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg acgtgctgcg 600 acgctttttt tctggcaaga tagtcttgta aatgcgggcc aggatctgca cactggtatt 660 tcggtttttg ggcccgcggc cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg 720 aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg 780 cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg 840 gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctccaggg 900 ggctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg 960 aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg 1020 tccaggcacc tcgattagtt ctggagcttt tggagtacgt cgtctttagg ttggggggag 1080 gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct 1140 tggcacttga tgtaattctc cttggaattt ggcctttttg agtttggatc ttggttcatt 1200 ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcagagctt ccttcttctt 1260 tttcctagaa gctcagaata aacgctcaac tttggccgcc acc 1303 <210> 703 <211> 1327 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 703 agtcattggg tttttccagc caatttataa aacgccatgt actttcccac cattgacgtc 60 aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca tagctgatta 120 atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg gcagccaaaa 180 cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc tattggctga 240 gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc agtcttgggt 300 ctgaccgccg tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg 360 aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt 420 cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta 480 gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac 540 tccggccgca ctctggtctt tttttttttt gttgttgttg ccctgctgcc ttcgattgcc 600 gttcagcaat aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga 660 ggtcatggtt ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg 720 agcacatgtc cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag 780 gctggggtta gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg 840 cgccgcgttg ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt 900 gcgtggaaag atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc 960 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc 1020 ggctgctgct tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg 1080 agcacggcta gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg 1140 gtgggtggag actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct 1200 tgagttttga gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc 1260 cttttttaga gcttccttct tctttttcct agaagctcag aataaacgct caactttggc 1320 cgccacc 1327 <210> 704 <211> 901 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 704 agtcattggg tttttccagc caatttataa aacgccatgt actttcccac cattgacgtc 60 aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca tagctgatta 120 atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg gcagccaaaa 180 cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc tattggctga 240 gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc agtcttgggt 300 ctgaccaccg tagaacgcag agctcctcgc tgcagtatcc tgcccaagaa agagcgacct 360 cagatcctca ctctcttccg catcgctgtc tgcgagggcc agctgttggg ctcgcggttg 420 aggacaaact cttcgcggtc tttccagtac tcttggatcg gaaacccgtc ggcctccgaa 480 cggtactccg ccaccgaggg acctgagcga gtccgcatcg accggatcgg aaaacctctc 540 gagaaaggcg tctaaccagt cacagtcgca aggtaggctg agcaccgtgg cgggcggcag 600 cgggtggcgg tcggggttgt ttctggcgga ggtgctgctg atgatgtaat taaagtaggc 660 ggtcttgaga cggcggatgg tcgaggtgag gtgtggcagg cttgagatcc agctgttggg 720 gtgagtactc cctctcaaaa gcgggcatta cttctgcgct aagattgtca gtttccaaaa 780 acgaggagga tttgatattc acctggcccg atctggccat acacttgagt gacaatgaca 840 tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaagtttaa acgccgccac 900 c 901 <210> 705 <211> 456 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 705 gcacatcgcc cacagtcccc gagaagttgg gaggggtcgg caattgaacc ggtgcctaga 60 gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg 120 agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg 180 ggtttgccgc cagaacacag cctggcagaa ctcggtaagt ctgttgacat gtatgtgatg 240 tatactaacc tgcatgggac gtggatttac ttgtgtatgt cagatagagt aaagattaac 300 tcttgcatgt gagcggggca tcgagatagc gataaatgag tcaggaggac ggatacttat 360 atgtgttgtt atcctcctct acagtcaaac agattaagag cttccttctt ctttttccta 420 gaagctcaga ataaacgctc aactttggcc gccacc 456 <210> 706 <211> 1206 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 706 gcacatcgcc cacagtcccc gagaagttgg gaggggtcgg caattgaacc ggtgcctaga 60 gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg 120 agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg 180 ggtttgccgc cagaacacag gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga 240 ggtcctgctc cgagcgggcc gggccccgct gtcgtcggcg gggattagct gcgagcattc 300 ccgcttcgag ttgcgggcgg cgcgggaggc agagtgcgag gcctagcggc aaccccgtag 360 cctcgcctcg tgtccggctt gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact 420 ccggccgcac tctggtcttt tttttttttg ttgttgttgc cctgctgcct tcgattgccg 480 ttcagcaata ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag 540 gtcatggttg gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga 600 gcacatgtcc gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg 660 ctggggttag cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc 720 gccgcgttgc cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg 780 cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca 840 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg 900 gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga 960 gcacggctag tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg 1020 tgggtggaga ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt 1080 gagttttgag cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc 1140 ttttttagag cttccttctt ctttttccta gaagctcaga ataaacgctc aactttggcc 1200 gccacc 1206 <210> 707 <211> 729 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 707 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 60 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 120 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 180 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 240 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 300 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 360 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 420 cggcagtcgc cttggacgtt ctttttcgca acgggtttgc cgtcagaacg cagcctggca 480 gaactcggta agtctgttga catgtatgtg atgtatacta acctgcatgg gacgtggatt 540 tacttgtgta tgtcagatag agtaaagatt aactcttgca tgtgagcggg gcatcgagat 600 agcgataaat gagtcaggag gacggatact tatatgtgtt gttatcctcc tctacagtca 660 aacagattaa gagcttcctt cttctttttc ctagaagctc agaataaacg ctcaactttg 720 gccgccacc 729 <210> 708 <211> 1454 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 708 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 60 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 120 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 180 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 240 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 300 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 360 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 420 cggcagtcgc cttggacgtt ctttttcgca acgggtttgc cgtcagaacg caggtaagtg 480 ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc gtgccttgaa 540 ttacttccac ctggctccag tacgtgattc ttgatcccga gctggagcca ggggcgggcc 600 ttgcgcttta ggagcccctt cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg 660 ccgccgcgtg cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct 720 agccatttaa aatttttgat gacgtgctgc gacgcttttt ttctggcaag atagtcttgt 780 aaatgcgggc caggatctgc acactggtat ttcggttttt gggcccgcgg ccggcgacgg 840 ggcccgtgcg tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag 900 aatcggacgg gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc 960 gtgtatcgcc ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga 1020 aagatggccg cttcccggcc ctgctccagg gggctcaaaa tggaggacgc ggcgctcggg 1080 agagcgggcg ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc 1140 ttcatgtgac tccacggagt accgggcgcc gtccaggcac ctcgattagt tctggagctt 1200 ttggagtacg tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac 1260 tgagtgggtg gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt 1320 tggccttttt gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt 1380 ttttcttcca tttcagagct tccttcttct ttttcctaga agctcagaat aaacgctcaa 1440 ctttggccgc cacc 1454 <210> 709 <211> 1015 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 709 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 60 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 120 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 180 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 240 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 300 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 360 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 420 cggcagtcgc cttggacgtt ctttttcgca acgggtttgc cgtcagaacg cagtcagatc 480 ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca 540 aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtac 600 tccgccaccg agggacctga gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa 660 ggcgtctaac cagtcacagt cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg 720 gcggtcgggg ttgtttctgg cggaggtgct gctgatgatg taattaaagt aggcggtctt 780 gagacggcgg atggtcgagg tgaggtgtgg caggcttgag atccagctgt tggggtgagt 840 actccctctc aaaagcgggc attacttctg cgctaagatt gtcagtttcc aaaaacgagg 900 aggatttgat attcacctgg cccgatctgg ccatacactt gagtgacaat gacatccact 960 ttgcctttct ctccacaggt gtccactccc aggtccaagt ttaaacgccg ccacc 1015 <210> 710 <211> 1181 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 710 gcacatcgcc cacagtcccc gagaagttgg gaggggtcgg caattgaacc ggtgcctaga 60 gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg 120 agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg 180 ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta 240 cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctccagtac gtgattcttg 300 atcccgagct ggagccaggg gcgggccttg cgctttagga gccccttcgc ctcgtgcttg 360 agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc 420 ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac gtgctgcgac 480 gctttttttc tggcaagata gtcttgtaaa tgcgggccag gatctgcaca ctggtatttc 540 ggtttttggg cccgcggccg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag 600 gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc 660 tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc 720 ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctccaggggg 780 ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa 840 aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc 900 caggcacctc gattagttct ggagcttttg gagtacgtcg tctttaggtt ggggggaggg 960 gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg 1020 gcacttgatg taattctcct tggaatttgg cctttttgag tttggatctt ggttcattct 1080 caagcctcag acagtggttc aaagtttttt tcttccattt cagagcttcc ttcttctttt 1140 tcctagaagc tcagaataaa cgctcaactt tggccgccac c 1181 <210> 711 <211> 669 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 711 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccaagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 360 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 420 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 480 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 540 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta ccgtcgcagt 600 cttgggtctg accaccgtag aacgcagagc tcctcgctgc agtatcctgc ccaagaaaga 660 gccgccacc 669 <210> 712 <211> 575 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 712 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta 240 taaaacgcca tgtactttcc caccattgac gtcaatgggc tattgaaact aatgcaacgt 300 gacctttaaa cggtactttc ccatagctga ttaatgggaa agtaccgttc tcgagccaat 360 acacgtcaat gggaagtgaa agggcagcca aaacgtaaca ccgccccggt tttcccctgg 420 aaattccata ttggcacgca ttctattggc tgagctgcgt tctacgtggg tataagaggc 480 gcgaccagcg tcggtaccgt cgcagtcttg ggtctgacca ccgtagaacg cagagctcct 540 cgctgcagta tcctgcccaa gaaagagccg ccacc 575 <210> 713 <211> 671 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 713 gggctctgga gacgacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc 60 ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga 120 cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat 180 atgccaagtc cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc 240 cagtacatga ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct 300 attaccatgg tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca 360 cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat 420 caacgggact ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg 480 cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540 agaggccatc cacgctgttt tgacctccat agtggacacc gggaccgatc cagcctccgc 600 ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca agagtgacgt ccaagtttaa 660 acgccgccac c 671 <210> 714 <211> 577 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 714 gccgccatat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca 60 ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact 120 ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc 180 attattggca cgtacataag gtcaataggg gtgtggtgat gcggttttgg cagtacacca 240 atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 300 atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg 360 ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc 420 gtttagtgaa ccgtcagatc gcctggagag gccatccacg ctgttttgac ctccatagtg 480 gacaccggga ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc 540 gtgccaagag tgacgtccaa gtttaaacgc cgccacc 577 <210> 715 <211> 462 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 715 tcttctttct agactgacca aagacttttt gtcaacttgt acaatctgaa gcaatgtctg 60 gcccacagac agctgagctg taaacaaatg tcacatggaa ataaatactt tatcttgtga 120 actcacttta ttgtgaagga atttgttttg tttttcaaac ctttcctgcg gtgttgacag 180 cccaaggatt atctgaatag agcctaggaa ctggaaatgg aacagtgcag tctgatggta 240 cttaagggag aaagagggaa aggaggtgtg gaagaagaaa aaagagaagc aagggggggg 300 ggagaaaggg agagggagag ggagagggag agggagaggg agagggagag ggagagggag 360 agggagaggg agagggagag ggagggggag agagagagag agagagagag agagagagag 420 agagagagag agagagagag agagcatgca ctctaacagc aa 462 <210> 716 <211> 463 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 716 tcttctttct agactgacca aagacttttt gtcaacttgt acaatctgaa gcaatgtctg 60 gcccacagac agctgagctg taaacaaatg tcacatggaa ataaatactt tatcttgtga 120 actcacttta ttgtgaagga atttgttttg tttttcaaac ctttcctgcg gtgttgacag 180 cccaaggatt atctgaatag agcctaggaa ctggaaatgg aacagtgcag tctgatggta 240 cttaagggag aaagagggaa aggaggtgtg gaagaagaaa aaagagaagc aagggggagg 300 gggagaaagg gagagggaga gggagaggga gagggagagg gagagggaga gggagaggga 360 gagggagagg gagagggagg gggaggggga gagagagaga gagagagaga gagagagaga 420 gagagagaga gagagagaga gagagcatgc actctaacag caa 463 <210> 717 <211> 449 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 717 gatccttttc cctctgacca gaattatggg aacatcatga agccccttga gcatctagct 60 tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 120 tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt 180 tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga 240 ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg 300 acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta 360 aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc 420 atagctgtcc ctcttctctt atggagatc 449 <210> 718 <211> 415 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 718 tcttctttct agactgacca aagacttttt gtcaacttgt acaatctgaa gcaatgtctg 60 gcccacagac agctgagctg taaacaaatg tcacatggaa ataaatactt tatcttgtga 120 actcacttta ttgtgaagga atttgttttg tttttcaaac ctttcctgcg gtgttgacag 180 cccaaggatt atctgaatag agcctaggaa ctggaaatgg aacagtgcag tctgatggta 240 cttaagggag aaagagggaa aggaggtgtg gaagaagaaa aaagagaagc aagggggagg 300 gggagaaagg gagagggaga gggagaggga gagggagagg gagagggaga gggagaggga 360 gagggagagg gagagggagg gggaggggga gagagagcat gcactctaac agcaa 415 <210> 719 <211> 284 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 719 ttgacttgac tcatgcttgt ttcactttca catggaattt cccagttatg aaattaataa 60 aaatcaatgg tttccacatc tgtgtgtgcc tgtgtcaccg acccaggtag ggctggcctt 120 gggggagggg gaggccagaa tgactccaag agctacagga aggcaggtca gagaaggggg 180 aggggggggc ggcgcgcagt gtggatctta tatctagtcc ccagggggag ggggcaataa 240 aagatcttta ttttcattag atctgtgtgt tggttttttg tgtg 284 <210> 720 <211> 353 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 720 ttgacttgac tcatgcttgt ttcactttca catggaattt cccagttatg aaattaataa 60 aaatcaatgg tttccacatc tgtgtgtgcc tgtgtcaccg acccaggtag ggctggcctt 120 gggggagggg gaggccagaa tgactccaag agctacagga aggcaggtca gagatcccac 180 tggacaaaca gtggctggac tctgcaccat aacacacaat caacagggga gtgagctgga 240 tccaggggga ggggggggcg gcgcgcagtg tggatcttat atctagtccc cagggggagg 300 gggcaataaa agatctttat tttcattaga tctgtgtgtt ggttttttgt gtg 353 <210> 721 <211> 424 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 721 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaactgtac ttggctcact ctccttctcc 120 ttacatagga aattacccag ttatgaaatt aataaaaagc cagtgatccc cacatttgtc 180 tgtgcctctg cctaggggct ggcctgggag gggagaaaaa ggccagaata attccaggaa 240 ccgccaagaa ggcaggtcag agatcttgct ggacaaacag tggctgaact ctgttcctta 300 acagagtcag cagcaggggg aggggggggc ggcgcgcagt gtggatctta tatctagtcc 360 ccagggggag ggggcaataa aagatcttta ttttcattag atctgtgtgt tggttttttg 420 tgtg 424 <210> 722 <211> 330 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 722 ctgtacttgg ctcactctcc ttctccttac ataggaaatt acccagttat gaaattaata 60 aaaagccagt gatccccaca tttgtctgtg cctctgccta ggggctggcc tgggagggga 120 gaaaaaggcc agaataattc caggaaccgc caagaaggca ggtcagagat cttgctggac 180 aaacagtggc tgaactctgt tccttaacag agtcagcagc agggggaggg gggggcggcg 240 cgcagtgtgg atcttatatc tagtccccag ggggaggggg caataaaaga tctttatttt 300 cattagatct gtgtgttggt tttttgtgtg 330 <210> 723 <211> 463 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 723 tcttctttct agactgacca aagacttttt gtcaacttgt acaatctgaa gcaatgtctg 60 gcccacagac agctgagctg taaacaaatg tcacatggaa ataaatactt tatcttgtga 120 actcacttta ttgtgaagga atttgttttg tttttcaaac ctttcctgcg gtgttgacag 180 cccaaggatt atctgaatag agcctaggaa ctggaaatgg aacagtgcag tctgatggta 240 cttaagggag aaagagggaa aggaggtgtg gaagaagaaa aaagagaagc acgggggagg 300 gggagaaagg gagagggaga gggagaggga gagggagagg gagagggaga gggagaggga 360 gagggagagg gagagggagg gggaggggga gagagagaga gagagagaga gagagagaga 420 gagagagaga gagagagaga gagagcatgc actctaacag caa 463 <210> 724 <211> 239 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 724 ctgtcttcca gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca 60 gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat 120 aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg 180 ggagatgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta agaagacag 239 <210> 725 <211> 147 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 725 ctgtcttccc aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 60 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 120 caatgtatct tatcatgtcg aagacag 147 <210> 726 <211> 287 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 726 ctgtcttcgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 60 tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 120 gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagtccc cattggggcc 180 aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 240 ggctcgcagc caacgtcggg gcggcaggcc ctgccatagg aagacag 287 <210> 727 <211> 65 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 727 ctgtcttcaa taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtggaa 60 gacag 65 <210> 728 <211> 264 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 728 ctgtcttccc aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 60 aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 120 caatgtatct tatcatgtca aatcgataat atatggtagg gttcatagcc agagtaacct 180 ttttttttaa tttttatttt attttatttt tgagtcgggc gcgccaaaat gaagtgaagt 240 tcctatactt tctagagaag acag 264 <210> 729 <211> 404 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 729 ctgtcttcgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 60 tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 120 gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagtccc cattggggcc 180 aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 240 ggctcgcagc caacgtcggg gcggcaggcc ctgccataga aatcgataat atatggtagg 300 gttcatagcc agagtaacct ttttttttaa tttttatttt attttatttt tgagtcgggc 360 gcgccaaaat gaagtgaagt tcctatactt tctagagaag acag 404 <210> 730 <211> 347 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 730 ctgtcttcat ccacaagccc agctccccac ccatcaccat ggacaatgtt tttttactaa 60 cacttggaca atgatggata cttttttact aacacttgga caatgatgat gatacactcc 120 tcacttgccc acttagacac aattactaac accacacccc ctcttttatt tctctgtact 180 taatgttttc tgaataaagt gatcctattg tacccacatt aaagacttct ttaactcttt 240 atggttcaca ggacccgaga tgaacataga tattgttaca gcagcggcct ccatgtcagg 300 tataactact gcctcacaca gcgccctgcc aatcagaagg aagacag 347 <210> 731 <211> 280 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 731 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc 280 <210> 732 <211> 852 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 732 aatattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa cggtgtcaga 60 actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa tgataacaat 120 gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg gttttctttt 180 ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa tggaaacaac 240 ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat gagaaacctg 300 tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag attgagatta 360 acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct gttggtattc 420 attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag tggcatttct 480 tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt gtatatatat 540 atcagttact gttatggatc ccacgtcact attgtatact ctatattata ctctatgtta 600 tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta agtctcccgt 660 gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc cggtatcgat 720 tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag cgcccctctt 780 aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg ggcatccgct 840 actcccgagc tc 852 <210> 733 <211> 675 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 733 aaatattacc cctaacacct gccaccccag tcttaatcag tggtggaaga actctcagaa 60 ctgtttgtct caattggcca tttaagttta atagtgaaag actggttaat gataacaatg 120 catcggaaaa ccttcaggag gaaaggagaa tgttttgtgg aacatttttg tgtgtgtggc 180 agttttaagt tattagtttt caaaatcagt actttttaat ggaaacaact tgaccaaaaa 240 tctgtcacag aattttgaac ccattaaaat acaagtttaa tgagaagtct gtctctgtta 300 atgctgaagt cattactaag tgcttagctt agcaaggtat gtggatgccc atttgtgttc 360 caagggattg gactgttcat caggacccag agctgtgtat actctatatt atactctatg 420 ttatactctg taatcctact caataaacgt gtcacgcctg tgaaaccgta ctaagtctcc 480 cgtgtcttct tatcaccatc aggtgacatc ctcgcccagg ctgtcaatca tgccggtatc 540 gattccagta gcaccggccc cacgctgaca acccactctt gcagcgttag cagcgcccct 600 cttaacaagc cgacccccac cagcgtcgcg gttactaaca ctcctctccc cggggcatcc 660 gctactcccg agctc 675 <210> 734 <211> 666 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 734 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaagttaaa 660 tgagaa 666 <210> 735 <211> 403 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 735 ctgtcttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg 60 tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat 120 ttggtttaga gtttggcaac atatgcccat atgctggctg ccatgaacaa aggttggcta 180 taaagaggtc atcagtatat gaaacagccc cctgctgtcc attccttatt ccatagaaaa 240 gccttgactt gaggttagat tttttttata ttttgttttg tgttattttt ttctttaaca 300 tccctaaaat tttccttaca tgttttacta gccagatttt tcctcctctc ctgactactc 360 ccagtcatag ctgtccctct tctcttatgg agatcgaaga cag 403 <210> 736 <211> 469 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 736 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtttac ctgactcatg gtcctttcac 120 tttcacatgg gatttcccag ttatgaaatt aataaaaatc agtgatttcc acatctgtgt 180 gtgcctgtgc caggctgggt ggggaacagg aggccgagat gattccggga actgtcagaa 240 ggaatcaatg atttccacat cctgtctgtc ttatgtcttg gggggtgggg aggccaggaa 300 gattccagga aggtcagagt caatcaatgg tttccacatc tctcagtgcc tctatctgga 360 ggccaggtag ggctggcctt gggggagggg gaggccagaa tgactccaag agctacagga 420 aggggggagg gggaaaaagg ccagaataat tccaggaacc gccaagaag 469 <210> 737 <211> 682 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 737 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aa 682 <210> 738 <211> 748 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 738 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaa 748 <210> 739 <211> 851 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 739 atattatccc taatacttgc caccccactc ttaatcagtg gtggaagaac ggtgtcagaa 60 ctgtttgttt caattggcca tttaagttta gtagtaaaag actggttaat gataacaatg 120 catcgtaaaa ccttcagaag gaaaggagaa tgttttgtgg accactttgg ttttcttttt 180 tgcgtgtggc agttttaagt tattagtttt taaaatcagt actttttaat ggaaacaact 240 tgaccaaaaa tttgtcacag aattttgaga tccattaaaa aagttaaatg agaaacctgt 300 gtgttccttt ggtcaacacc gagacattta ggtgaaagca tatactgaga ttgagattaa 360 cttcctgtga aacccagtgt cttagacaac tgtggcttga gcaccacctg ttggtattca 420 ttacaaactt gctcactaca ataaatgaat tttaagcttt aagatgaagt ggcatttctt 480 ttaacagtta ctatgttgga attggttaca aattttggag tggactattg tatatatata 540 tcagttactg ttatggatcc cacgtcacta ttgtatactc tatattatac tctatgttat 600 actctgtaat cctactcaat aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg 660 tcttgttatc accatcaggt gacatcctcg cccaggctgt caatcatgcc ggtatcgatt 720 ccagtagcac cggccccacg ctgacaaccc actcttgcag cgttagcagc gcccctctta 780 acaagccgac ccccaccagc gtcgcggtta ctaacactcc tctccccggg gcatccgcta 840 ctcccgagct c 851 <210> 740 <211> 760 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 740 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaagt taaatgagaa 760 <210> 741 <211> 358 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 741 ctgtcttccc gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc 60 cctcctcccc tccttgcacc ggcccttcct ggtctttgaa taaaaacttg tttattgcag 120 cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt 180 cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtcaaatcga 240 taatatatgg tagggttcat agccagagta accttttttt ttaattttta ttttatttta 300 tttttgagtc gggcgcgcca aaatgaagtg aagttcctat actttctaga gaagacag 358 <210> 742 <211> 447 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 742 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgact tgactcatgc ttgtttcact 120 ttcacatgga atttcccagt tatgaaatta ataaaaatca atggtttcca catctgtgtg 180 tgcctgtgtc accgacccag gtagggctgg ccttggggga gggggaggcc agaatgactc 240 caagagctac aggaaggcag gtcagagatc ccactggaca aacagtggct ggactctgca 300 ccataacaca caatcaacag gggagtgagc tggatccagg gggagggggg ggcggcgcgc 360 agtgtggatc ttatatctag tccccagggg gagggggcaa taaaagatct ttattttcat 420 tagatctgtg tgttggtttt ttgtgtg 447 <210> 743 <211> 333 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 743 ctgtcttcgc tggagcctcg gtagccgttc ctcctgcccg ctgggcctcc caacgggccc 60 tcctcccctc cttgcaccgg cccttcctgg tctttgaata aacagacatg ataagataca 120 ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa 180 tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca 240 acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagca 300 agtaaaacct ctacaaatgt ggtaagaaga cag 333 <210> 744 <211> 543 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 744 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagatcct tttccctctg accagaatta 120 tgggaacatc atgaagcccc ttgagcatct agcttctggc taataaagga aatttatttt 180 cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc 240 aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat 300 gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc 360 tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt 420 ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc 480 cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag 540 atc 543 <210> 745 <211> 1509 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 745 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agaaacttga tctgtcgccg caattcaagc 420 ttcgtgaggc tccggtgccc gtcagtgacc tgctatactc tggagacgca acctttggag 480 ctaagccagc aatggtagag ggaagattct gcacgtccct tccaggcggc ctccccgtca 540 ccaccccccc caacccgccc cgaccggagc tgagagtaat tcatacaaaa ggactcgccc 600 ctgccttggg gaatcccagg gaccgtcgtt aaactcccac taacgtagaa cccagagatc 660 gctgcgttcc cgccccctca cccgcccgct ctcgtcatca ctgaggtgga gaatagcatg 720 cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt 780 tggggggagg ggtcggcaat tgaacgggtg cctagagaag gtggcgcggg gtaaactggg 840 aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa 900 gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacagcgtc 960 tcaggggcga gacctctcac tctcttccgc atcgctgtct gcgagggcca gctgttgggc 1020 tcgcggttga ggacaaactc ttcgcggtct ttccagtact cttggatcgg aaacccgtcg 1080 gcctccgaac ggtactccgc caccgaggga cctgagcgag tccgcatcga ccggatcgga 1140 aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc 1200 gggcggcagc gggtggcggt cggggttgtt tctggcggag gtgctgctga tgatgtaatt 1260 aaagtaggcg gtcttgagag ggcggatggt cgaggtgagg tgtggcaggc ttgagatcca 1320 gctgttgggg tgagtactcc ctctcaaaag cgggcattac ttctgcgcta agattgtcag 1380 tttccaaaaa cgaggaggat ttgatattca cctggcccga tctggccata cacttgagtg 1440 acaatgacat ccactttgcc tttctctcca caggtgtcca ctcccaggtc caagtttaaa 1500 gccgccacc 1509 <210> 746 <211> 1904 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 746 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga cttacggtaa atggcccgcc tggctgaccg 1020 cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata 1080 gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta 1140 catcaagtgt atcatatgcc aagtccgccc cctattgacg tcaatgacgg taaatggccc 1200 gcctggcatt atgcccagta catgacctta cgggactttc ctacttggca gtacatctac 1260 gtattagtca tcgctattac caatgacgtc gaggagaagt tccccaactt tcccgcctct 1320 cagcctttga aagaaagaaa ggggaggggg caggccgcgt gcagccgcga gcggtgctgg 1380 gctccggctc caattcccca tctcagtcgt tcccaaagtc ctcctgtttc atccaagcgt 1440 gtaagggtcc ccgtccttga ctccctagtg tcctgctgcc cacagtccag tcctgggaac 1500 cagcaccgat cacctcccat cgggccaatc tcagtccctt cccccctacg tcggggccca 1560 cacgctcggt gcgtgcccag ttgaaccagg cggctgcgga aaaaaaaaag cggggagaaa 1620 gtagggcccg gctactagcg gttttacggg cgcacgtagc tcaggcctca agaccttggg 1680 ctgggactgg ctgagcctgg cgggaggcgg ggtccgagtc accgcctgcc gccgcgcccc 1740 cggtttctat aaattgagcc cgcagcctcc cgcttcgctc tctgctcctc ctgttcgaca 1800 gtcagccgca tcttcttttg cgtcgccagc gtctcagggg cgagaccagc ttgcttgttc 1860 tttttgcaga agctcagaat aaacgctcaa ctttggccgc cacc 1904 <210> 747 <211> 1383 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 747 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agaaacttga tctgtcgccg caattcaagc 420 ttcgtgaggc tccggtgccc gtcagtgacc tgctatactc tggagacgac ttacggtaaa 480 tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt 540 tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta 600 aactgcccac ttggcagtac atcaagtgta tcatatgcca agtccgcccc ctattgacgt 660 caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttac gggactttcc 720 tacttggcag tacatctacg tattagtcat cgctattacc aatgacgtcg aggagaagtt 780 ccccaacttt cccgcctctc agcctttgaa agaaagaaag gggagggggc aggccgcgtg 840 cagccgcgag cggtgctggg ctccggctcc aattccccat ctcagtcgtt cccaaagtcc 900 tcctgtttca tccaagcgtg taagggtccc cgtccttgac tccctagtgt cctgctgccc 960 acagtccagt cctgggaacc agcaccgatc acctcccatc gggccaatct cagtcccttc 1020 ccccctacgt cggggcccac acgctcggtg cgtgcccagt tgaaccaggc ggctgcggaa 1080 aaaaaaaagc ggggagaaag tagggcccgg ctactagcgg ttttacgggc gcacgtagct 1140 caggcctcaa gaccttgggc tgggactggc tgagcctggc gggaggcggg gtccgagtca 1200 ccgcctgccg ccgcgccccc ggtttctata aattgagccc gcagcctccc gcttcgctct 1260 ctgctcctcc tgttcgacag tcagccgcat cttcttttgc gtcgccagcg tctcaggggc 1320 gagaccagct tgcttgttct ttttgcagaa gctcagaata aacgctcaac tttggccgcc 1380 acc 1383 <210> 748 <211> 2120 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 748 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga ctacggtaaa tggcccgcct ggctgaccgc 1020 ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 1080 ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 1140 atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg 1200 cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg 1260 tattagtcat cgctattacc aatgacgtcg aggagaagtt ccccaacttt cccgcctctc 1320 agcctttgaa agaaagaaag gggagggggc aggccgcgtg cagccgcgag cggtgctggg 1380 ctccggctcc aattccccat ctcagtcgtt cccaaagtcc tcctgtttca tccaagcgtg 1440 taagggtccc cgtccttgac tccctagtgt cctgctgccc acagtccagt cctgggaacc 1500 agcaccgatc acctcccatc gggccaatct cagtcccttc ccccctacgt cggggcccac 1560 acgctcggtg cgtgcccagt tgaaccaggc ggctgcggaa aaaaaaaagc ggggagaaag 1620 tagggcccgg ctactagcgg ttttacgggc gcacgtagct caggcctcaa gaccttgggc 1680 tgggactggc tgagcctggc gggaggcggg gtccgagtca ccgcctgccg ccgcgccccc 1740 ggtttctata aattgagccc gcagcctccc gcttcgctct ctgctcctcc tgttcgacag 1800 tcagccgcat cttcttttgc gtcgccagcg tctcaggggc gagaccggtg aggtgtggca 1860 ggcttgagat ccagctgttg gggtgagtac tccctctcaa aagcgggcat tacttctgcg 1920 ctaagattgt cagtttccaa aaacgaggag gatttgatat tcacctggcc cgatctggcc 1980 atacacttga gtgacaatga catccacttt gcctttctct ccacaggtgt ccactcccag 2040 gtccaagttt aaacgccgcc accagcttgc ttgttctttt tgcagaagct cagaataaac 2100 gctcaacttt ggccgccacc 2120 <210> 749 <211> 1007 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 749 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agaaacttga tctgtcgccg caattcaaac 420 ttcgtgaggc tccggtgccc gtcagtgact tacggtaaat ggcccgcctg gctgaccgcc 480 caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg 540 gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca 600 tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc 660 ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt 720 attagtcatc gctattacca gcacatcgcc cacagtcccc gagaagttgg ggggaggggt 780 cggcaattga accggtgcct agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt 840 gtactggctc cgcctttttc ccgagggtgg gggagaaccg tatataagtg cagtagtcgc 900 cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca cagccatcta ttgcttacat 960 ttgcttctga cacaactgtg ttcactagca acctcaaaca gacacca 1007 <210> 750 <211> 2033 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 750 gctcttctat gactgccctg accgaaggtg ctaagctgtt tgagaaggag attccgtaca 60 tcaccgagct ggaaggggac gtcgaaggaa tgaagttcat catcaaggga gaaggaaccg 120 gggacgctac gactggaacc attaaggcca agtatatctg taccactgga gatctgccag 180 tgccttgggc cacccttgtg tcaaccctct cgtatggagt gcagtgtttt gctaagtacc 240 ctagccacat taaggacttc ttcaaatccg ccatgccgga aggttatacc caagagcgca 300 ccatttcttt tgagggagat ggagtgtaca agacccgcgc gatggtcacc tatgagaggg 360 gatctatcta caaccgggtg actctgactg gagaaaactt taagaaggac gggcatattc 420 ttcggaagaa tgtcgccttc cagtgccctc ccagcatcct ttacattctc cccgacactg 480 tgaacaacgg aatccgcgtg gagttcaatc aagcctacga catcgagggg gtgacggaga 540 agctggtgac caagtgtagc cagatgaatc ggccactggc cggttcagcg gctgtccaca 600 ttccgcgcta ccatcatatc acttatcaca ctaagctctc caaagaccgc gatgagagga 660 gagatcacat gtgcctggtg gaagtggtca aggccgtcga tctcgatacc tatcagtaag 720 gttaaaaaat tccgcccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg 780 tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc 840 cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa 900 ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga 960 caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc 1020 ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc 1080 cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac 1140 aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg 1200 tacacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg 1260 gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccat ggtgtcaaaa 1320 ggggaggaat tgatcaaaga gaacatgcat atgaaactgt acatggaggg aactgtcaac 1380 aatcaccact tcaaatgcac ctcagagggc gagggaaagc cctacgaagg gacccagacc 1440 atgcgcatta aggtggtcga aggcggacca ctcccttttg cattcgacat cctggctacc 1500 tccttcatgt acggatcgcg cacttttatc aagtacccga aggggatccc ggacttcttc 1560 aagcaatcct tccctgaggg attcacttgg gaacgggtca cgacctacga agatggaggc 1620 gtggtgaccg tgatgcaaga cactagcctg gaagatggct gccttgtcta caacgtgaag 1680 atcagaggtg tgaacttccc atccaatggc cccgtgatgc agaaaaagac tctggggtgg 1740 gaagccaata ccgaaatgct ctacccagcg gacggaggac tcgaaggccg gtctgacatg 1800 gccctgaagc tggtcggagg aggacatttg tcgtgtagct ttgtgactac gtaccggtcg 1860 aagaagccgg ccaaaaacct gaagatgccg ggtatccacg cggtggacca tagactggaa 1920 cgcctggagg agagcgataa cgagatgttc gtcgttcaga gggaacacgc tgtggcacga 1980 tattgcgatc tcccgtcgaa gcttggtcac aagctcaatt agggtagaag agc 2033 <210> 751 <211> 2032 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 751 attatcccta atacctgcca ccccactctt aatcagtggt ggaagaacgg tgtcagaact 60 gtttgtttca attggccatt taagtttagt agtaaaagac tggttaatga taacaatgca 120 tcgtaaaacc ttcagaagga aaggagaatg ttttgtggac cactttggtt ttcttttttg 180 cgtgtggcag ttttaagtta ttagttttta aaatcagtac tttttaatgg aaacaacttg 240 accaaaaatt tgtcacagaa ttttgacacc cattaaaaaa gttaaatgag aaacctgtgt 300 gttcctttgg agaggggcgg aagggacgtt aggagggagg cagggaggca gggaggcagg 360 gaggaacgga gggaggaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 420 gcccgtcagt gacctgctat actctggaga cgctgggaag ggtccctagg attgtgcacc 480 tctcccgcgg gggacaagca ggggatggcg gggctgacgt cgggaggtgg cctccacggg 540 aagggacacc cggatctcga cacagccttg gcagtggagt caggaagggt aggacagatt 600 ctggacgccc tcttggccag tcctcaccgc cccacccccg atggagccga gagtaattca 660 tacaaaagga gggatcgcct tcgcccctgg gaatcccagg gaccgtcgct aaattctggc 720 cggcctccca gcccggaacc gctgtgcccg cccagcgcgg cgggaggagc ctgcgcctag 780 ggcggatcgc gggtcggcgg gagagcacaa gcccacagtc cccggcggtg ggggaggggc 840 gcgctgagcg ggggcccggg agccagcgcg gggcaaactg ggaaagtggt gtcgtgtgct 900 ggctccgccc tcttcccgag ggtgggggag aacggtataa aagtgcggta gtcgcgttgg 960 acgttctttt tcgcaacggg tttgccgtca gaacgcaggt gagtggcggg tgtggcctcc 1020 gcgggcccgg gctccctcct ttgagcgggg tcggaccgcc gtgcgggtgt cgtcggccgg 1080 gcttctctgc gagcgttccc gccctggatg gcgggctgtg cgggagggcg agggggggag 1140 gcctggcggc ggccccggag cctcgcctcg tgtcgggcgt gaggcctagc gtggcttccg 1200 ccccgccgcg tgccaccgcg gccgcgcttt gctgtctgcc cggctgccct cgattgcctg 1260 cccgcggccc gggccaacaa agggagggcg tggagctggc tggtagggag ccccgtagtc 1320 cgcatgtcgg gcagggagag cggcagcagt cggggggggg accgggcccg cccgtcccgc 1380 agcacatgtc cgacgccgcc tggacgggta gcggcctgtg tcctgataag gcggccgggc 1440 ggtgggtttt agatgccggg ttcaggtggc cccgggtccc ggcccggtct ggccagtacc 1500 ccgtagtggc ttagctccga ggagggcgag cccgcccgcc cggcaccagt tgcgtgcgcg 1560 gaaagatggc cgctcccggg ccctgtagca aggagctcaa aatggaggac gcggcagccc 1620 ggcggagcgg ggcgggtgag tcacccacac aaaggaagag ggccttgccc ctcgccggcc 1680 gctgcttcct gtgaccccgt ggtgtaccgg ccgcacttca gtcaccccgg gcgctctttc 1740 ggagcaccgc tggcctccgc tgggggaggg gatctgtcta atggcgttgg agtttgctca 1800 catttggtgg gtggagactg tagccaggcc agcctggcca tggaagtaat tcttggaatt 1860 tgcccatttt gagtttggag cgaagctgat tgacaaagct gcttagccgt tcaaaggtat 1920 tcttcgaact ttttttttaa ggtgttgtga aaaccaccgc taattcaaat ccaacagctt 1980 gcttgttctt tttgcagaag ctcagaataa acgctcaact ttggccgcca cc 2032 <210> 752 <211> 1979 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 752 attatcccta atacctgcca ccccactctt aatcagtggt ggaagaacgg tgtcagaact 60 gtttgtttca attggccatt taagtttagt agtaaaagac tggttaatga taacaatgca 120 tcgtaaaacc ttcagaagga aaggagaatg ttttgtggac cactttggtt ttcttttttg 180 cgtgtggcag ttttaagtta ttagttttta aaatcagtac tttttaatgg aaacaacttg 240 accaaaaatt tgtcacagaa ttttgacacc cattaaaaaa gttaaatgag aaacctgtgt 300 gttcctttgg agaggggcgg aagggacgtt aggagggagg cagggaggca gggaggcagg 360 gaggaacgga gggaggaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 420 gcccgtcagt gacctgctat actctggaga cgagcggggc tgacgtcggg aggtggcctc 480 cgtgggaagg gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg 540 atagattctg gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag 600 agtaattcat acaaaaggag ggatcgcctt cgcaagggga gagcccaggg accgtcccta 660 aattctcaca gacccaaatc cctgtagccg ccccacgaca gcgcgaggag catgcgctca 720 gggctgagcg cggggagagc agagcacaca agctcataga ccctggtcgt gggggggagg 780 accggggagc tggcgcgggg caaactggga aagcggtgtc gtgtgctggc tccgccctct 840 tcccgagggt gggggagaac ggtatataag tgcggcagtc gccttggacg ttctttttcg 900 caacgggttt gccgtcagaa cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag 960 ctggaggtcc tgctccgagc gggccgggcc ccgctgtcgt cggcggggat tagctgcgag 1020 cattcccgct tcgagttgcg ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc 1080 cgtagcctcg cctcgtgtcc ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg 1140 ctactccggc cgcactctgg tctttttttt ttttgttgtt gttgccctgc tgccttcgat 1200 tgccgttcag caataggggc taacaaaggg agggtgcggg gcttgctcgc ccggagcccg 1260 gagaggtcat ggttggggag gaatggaggg acaggagtgg cggctggggc ccgcccgcct 1320 tcggagcaca tgtccgacgc cacctggatg gggcgaggcc tggggttttt cccgaagcaa 1380 ccaggctggg gttagcgtgc cgaggccatg tggccccagc acccggcacg atctggcttg 1440 gcggcgccgc gttgccctgc ctccctaact agggtgaggc catcccgtcc ggcaccagtt 1500 gcgtgcgtgg aaagatggcc gctcccgggc cctgttgcaa ggagctcaaa atggaggacg 1560 cggcagcccg gtggagcggg cgggtgagtc acccacacaa aggaagaggg cctggtccct 1620 caccggctgc tgcttcctgt gaccccgtgg tcctatcggc cgcaatagtc acctcgggct 1680 tttgagcacg gctagtcgcg gcggggggag gggatgtaat ggcgttggag tttgttcaca 1740 tttggtgggt ggagactagt caggccagcc tggcgctgga agtcattttt ggaatttgtc 1800 cccttgagtt ttgagcggag ctaattctcg ggcttcttag cggttcaaag gtatctttta 1860 aacccttttt taggtgttgt gaaaaccacc gctaattcaa agcaagctaa ttcaaatcca 1920 acagcttgct tgttcttttt gcagaagctc agaataaacg ctcaactttg gccgccacc 1979 <210> 753 <211> 2561 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 753 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga gcggggctga cgtcgggagg tggcctccgt 1020 gggaagggac acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata 1080 gattctggcc gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt 1140 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 1200 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgctcaggg 1260 ctgagcgcgg ggagagcaga gcacacaagc tcatagaccc tggtcgtggg ggggaggacc 1320 ggggagctgg cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc gccctcttcc 1380 cgagggtggg ggagaacggt atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa 1440 cgggtttgcc gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg 1500 gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat 1560 tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt 1620 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta 1680 ctccggccgc actctggtct tttttttttt tgttgttgtt gccctgctgc cttcgattgc 1740 cgttcagcaa taggggctaa caaagggagg gtgcggggct tgctcgcccg gagcccggag 1800 aggtcatggt tggggaggaa tggagggaca ggagtggcgg ctggggcccg cccgccttcg 1860 gagcacatgt ccgacgccac ctggatgggg cgaggcctgg ggtttttccc gaagcaacca 1920 ggctggggtt agcgtgccga ggccatgtgg ccccagcacc cggcacgatc tggcttggcg 1980 gcgccgcgtt gccctgcctc cctaactagg gtgaggccat cccgtccggc accagttgcg 2040 tgcgtggaaa gatggccgct cccgggccct gttgcaagga gctcaaaatg gaggacgcgg 2100 cagcccggtg gagcgggcgg gtgagtcacc cacacaaagg aagagggcct ggtccctcac 2160 cggctgctgc ttcctgtgac cccgtggtcc tatcggccgc aatagtcacc tcgggctttt 2220 gagcacggct agtcgcggcg gggggagggg atgtaatggc gttggagttt gttcacattt 2280 ggtgggtgga gactagtcag gccagcctgg cgctggaagt catttttgga atttgtcccc 2340 ttgagttttg agcggagcta attctcgggc ttcttagcgg ttcaaaggta tcttttaaac 2400 ccttttttag gtgttgtgaa aaccaccgct aattcaaagc aacgtctcag gggctgtctt 2460 cgcaggagcc cgggctgggc ataaaagtca gggcagagcc atctattgct tacatttgct 2520 tctgacacaa ctgtgttcac tagcaacctc aaacagacac c 2561 <210> 754 <211> 2560 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 754 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga gcggggctga cgtcgggagg tggcctccgt 1020 gggaagggac acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata 1080 gattctggcc gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt 1140 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 1200 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgctcaggg 1260 ctgagcgcgg ggagagcaga gcacacaagc tcatagaccc tggtcgtggg ggggaggacc 1320 ggggagctgg cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc gccctcttcc 1380 cgagggtggg ggagaacggt atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa 1440 cgggtttgcc gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg 1500 gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat 1560 tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt 1620 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta 1680 ctccggccgc actctggtct tttttttttt gttgttgttg ccctgctgcc ttcgattgcc 1740 gttcagcaat aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga 1800 ggtcatggtt ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg 1860 agcacatgtc cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag 1920 gctggggtta gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg 1980 cgccgcgttg ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt 2040 gcgtggaaag atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2100 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc 2160 ggctgctgct tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg 2220 agcacggcta gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg 2280 gtgggtggag actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct 2340 tgagttttga gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc 2400 cttttttagg tgttgtgaaa accaccgcta attcaaagca acgtctcagg ggctgtcttc 2460 gcaggagccc gggctgggca taaaagtcag ggcagagcca tctattgctt acatttgctt 2520 ctgacacaac tgtgttcact agcaacctca aacagacacc 2560 <210> 755 <211> 2010 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 755 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacaa cctttggagc taagccagca atggtagagg 1020 gaagattctg cacgtccctt ccaggcggcc tccccgtcac cacccccccc aacccgcccc 1080 gaccggagct gagagtaatt catacaaaag gactcgcccc tgccttgggg aatcccaggg 1140 accgtcgtta aactcccact aacgtagaac ccagagatcg ctgcgttccc gccccctcac 1200 ccgcccgctc tcgtcatcac tgaggtggag aatagcatgc gtgaggctcc ggtgcccgtc 1260 agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt 1320 gaacgggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc 1380 tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg 1440 ttctttttcg caacgggttt gccgccagaa cacagtctca ctctcttccg catcgctgtc 1500 tgcgagggcc agctgttggg ctcgcggttg aggacaaact cttcgcggtc tttccagtac 1560 tcttggatcg gaaacccgtc ggcctccgaa cggtactccg ccaccgaggg acctgagcga 1620 gtccgcatcg accggatcgg aaaacctctc gagaaaggcg tctaaccagt cacagtcgca 1680 aggtaggctg agcaccgtgg cgggcggcag cgggtggcgg tcggggttgt ttctggcgga 1740 ggtgctgctg atgatgtaat taaagtaggc ggtcttgaga gggcggatgg tcgaggtgag 1800 gtgtggcagg cttgagatcc agctgttggg gtgagtactc cctctcaaaa gcgggcatta 1860 cttctgcgct aagattgtca gtttccaaaa acgaggagga tttgatattc acctggcccg 1920 atctggccat acacttgagt gacaatgaca tccactttgc ctttctctcc acaggtgtcc 1980 actcccaggt ccaagtttaa agccgccacc 2010 <210> 756 <211> 2046 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 756 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacaa cctttggagc taagccagca atggtagagg 1020 gaagattctg cacgtccctt ccaggcggcc tccccgtcac cacccccccc aagcggggct 1080 gacgtcggga ggtggcctcc gtgggaaggg acacccggat cttgacacag ccttggcagc 1140 ggagtaagga agagtaggga tagattctgg ccgccctctt ggccagcttc tcgccgcccc 1200 accctccgct agggccaaga gtaattcata caaaaggagg gatcgccttc gcaaggggag 1260 agcccaggga ccgtccctaa attctcacag acccaaatcc ctgtagccgc cccacgacag 1320 cgcgaggagc atgcgctcag ggctgagcgc ggggagagca gagcacacaa gctcatagac 1380 cctggtcgtg ggggggagga ccggggagct ggcgcggggc aaactgggaa agcggtgtcg 1440 tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtatataagt gcggcagtcg 1500 ccttggacgt ttctcactct cttccgcatc gctgtctgcg agggccagct gttgggctcg 1560 cggttgagga caaactcttc gcggtctttc cagtactctt ggatcggaaa cccgtcggcc 1620 tccgaacggt actccgccac cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 1680 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 1740 cggcagcggg tggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 1800 gtaggcggtc ttgagagggc ggatggtcga ggtgaggtgt ggcaggcttg agatccagct 1860 gttggggtga gtactccctc tcaaaagcgg gcattacttc tgcgctaaga ttgtcagttt 1920 ccaaaaacga ggaggatttg atattcacct ggcccgatct ggccatacac ttgagtgaca 1980 atgacatcca ctttgccttt ctctccacag gtgtccactc ccaggtccaa gtttaaagcc 2040 gccacc 2046 <210> 757 <211> 2100 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 757 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga cttacggtaa atggcccgcc tggctgaccg 1020 cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata 1080 gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta 1140 catcaagtgt atcatatgcc aagtccgccc cctattgacg tcaatgacgg taaatggccc 1200 gcctggcatt atgcccagta catgacctta cgggactttc ctacttggca gtacatctac 1260 gtattagtca tcgctattac caatgacgtc gaggagaagt tccccaactt tcccgcctct 1320 cagcctttga aagaaagaaa ggggaggggg caggccgcgt gcagccgcga gcggtgctgg 1380 gctccggctc caattcccca tctcagtcgt tcccaaagtc ctcctgtttc atccaagcgt 1440 gtaagggtcc ccgtccttga ctccctagtg tcctgctgcc cacagtccag tcctgggaac 1500 cagcaccgat cacctcccat cgggccaatc tcagtccctt cccccctacg tcggggccca 1560 cacgctcggt gcgtgcccag ttgaaccagg cggctgcgga aaaaaaaaag cggggagaaa 1620 gtagggcccg gctactagcg gttttacggg cgcacgtagc tcaggcctca agaccttggg 1680 ctgggactgg ctgagcctgg cgggaggcgg ggtccgagtc accgcctgcc gccgcgcccc 1740 cggtttctat aaattgagcc cgcagcctcc cgcttcgctc tctgctcctc ctgttcgaca 1800 gtcagccgca tcttcttttg cgtcgccagc gtctcagggg ccctggcaga actcggtaag 1860 tctgttgaca tgtatgtgat gtatactaac ctgcatggga cgtggattta cttgtgtatg 1920 tcagatagag taaagattaa ctcttgcatg tgagcggggc atcgagatag cgataaatga 1980 gtcaggagga cggatactta tatgtgttgt tatcctcctc tacagtcaaa cagattaagg 2040 ggtagcttgc ttgttctttt tgcagaagct cagaataaac gctcaacttt ggccgccacc 2100 <210> 758 <211> 2758 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 758 atattatccc taatacttgc caccccactc ttaatcagtg gtggaagaac ggtgtcagaa 60 ctgtttgttt caattggcca tttaagttta gtagtaaaag actggttaat gataacaatg 120 catcgtaaaa ccttcagaag gaaaggagaa tgttttgtgg accactttgg ttttcttttt 180 tgcgtgtggc agttttaagt tattagtttt taaaatcagt actttttaat ggaaacaact 240 tgaccaaaaa tttgtcacag aattttgaga tccattaaaa aagttaaatg agaaacctgt 300 gtgttccttt ggtcaacacc gagacattta ggtgaaagca tatactgaga ttgagattaa 360 cttcctgtga aacccagtgt cttagacaac tgtggcttga gcaccacctg ttggtattca 420 ttacaaactt gctcactaca ataaatgaat tttaagcttt aagatgaagt ggcatttctt 480 ttaacagtta ctatgttgga attggttaca aattttggag tggactattg tatatatata 540 tcagttactg ttatggatcc cacgtcacta ttgtatactc tatattatac tctatgttat 600 actctgtaat cctactcaat aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg 660 tcttgttatc accatcaggt gacatcctcg cccaggctgt caatcatgcc ggtatcgatt 720 ccagtagcac cggccccacg ctgacaaccc actcttgcag cgttagcagc gcccctctta 780 acaagccgac ccccaccagc gtcgcggtta ctaacactcc tctccccggg gcatccgcta 840 ctcccgagct cctctggaga cggtagcatc cttaggatcg agtcaatggg aaaaacccat 900 tggagccaag tacactgact caatagggac tttccattgg gttttgccca gtacataagg 960 tcaatagggg gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg 1020 gactttccaa tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt 1080 tcccattact gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac 1140 ataaggtcaa taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca 1200 atagggactt tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg 1260 gtttttccca ttattggcac atacataagg tcaatagggg tgagtcattg ggtttttcca 1320 gccaatttat aaaacgccat gtactttccc accattgacg tcaatgggct attgaaacta 1380 atgcaacgtg acctttaaac ggtactttcc catagctgat taatgggaaa gtaccgttct 1440 cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt 1500 ttcccctgga aattccatat tggcacgcat tctattggct gagctgcgtt ctacgtgggt 1560 ataagaggcg cgaccagcgt cggtaccgtc gcagtcttgg gtctgaccac cgtagaacgc 1620 agagctcctc gctgcagtat cctgcccaag aaagagcgac cttccccggc tactgaagcg 1680 catcggaccc gctcggttct attgggacca cgcccatccg ccatattgga acagccgcca 1740 tattggtaac gccgccatct tgattgggac caccgcccct attgggacca ccgcccaatt 1800 gggaccaccg cccacccagc gacccaggcc cagaggctac gtcaccagga cccccggctg 1860 cccagcgccc cctcgaggac acacaatgta agtagaccaa ggccttttat tggctgcggt 1920 gttaaggcaa gctgcctgtc tatccctatc tatctactat ccacctggct ctctagctcc 1980 atactgcgta cggtgtttgt tagcttaggg tgatagcaag tagaacgctg gtgatggttg 2040 ctctctatca gtttagcgct ggtgatggtg gcctccttct ccatttctta tatatatatg 2100 ctggtgatgg tccctcttcc atggccgcgg tgtgcttcgg tgccgggtac cgtaacgtgg 2160 tacagaaaaa ggcctgacac gtacgcttct ctccctagga tgctatgtgt ctgtagcacc 2220 ggcggagctt gcgagctcga tgtccaagat agagtctcca tgactgctca gattgtctcc 2280 tgtgttcaca caccagatat tacaagcgac ggccgccatg ataagtccaa aaatgagcag 2340 aatacagaat attgtactca gaggctgcag ccatcttggt ggcctgctgt ggtgctcttt 2400 tcccgtggag gactccgtca gttcctgcgt gttgttgctc gtactgcgaa gatctctctt 2460 gccccgtcct gaaaacctag gccctgacag aaaaaaggga gagttaggag agggcacaga 2520 ggattctgtc tgtgtcaagg gggcttccat gttgtttctt tacctgagat ctcttccacc 2580 agttgttttt tatcagcaac tgacaggtag tatatcaaaa tgagtgcact gatgattatt 2640 agcactgtat actttagata tcttctggtt tctgtggaca tctgttgatg ataaaaaatt 2700 atattttttt agagagcgtc tcaggggtgt gtcgtgaaaa ctacccctag ccgccacc 2758 <210> 759 <211> 4113 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 759 ggggatatta tccctaatac ttgccacccc actcttaatc agtggtggaa gaacggtgtc 60 agaactgttt gtttcaattg gccatttaag tttagtagta aaagactggt taatgataac 120 aatgcatcgt aaaaccttca gaaggaaagg agaatgtttt gtggaccact ttggttttct 180 tttttgcgtg tggcagtttt aagttattag tttttaaaat cagtactttt taatggaaac 240 aacttgacca aaaatttgtc acagaatttt gagatccatt aaaaaagtta aatgagaaac 300 ctgtgtgttc ctttggtcaa caccgagaca tttaggtgaa agcatatact gagattgaga 360 ttaacttcct gtgaaaccca gtgtcttaga caactgtggc ttgagcacca cctgttggta 420 ttcattacaa acttgctcac tacaataaat gaattttaag ctttaagatg aagtggcatt 480 tcttttaaca gttactatgt tggaattggt tacaaatttt ggagtggact attgtatata 540 tatatcagtt actgttatgg atcccacgtc actattgtat actctatatt atactctatg 600 ttatactctg taatcctact caataaacgt gtcacgcctg tgaaaccgta ctaagtctcc 660 cgtgtcttgt tatcaccatc aggtgacatc ctcgcccagg ctgtcaatca tgccggtatc 720 gattccagta gcaccggccc cacgctgaca acccactctt gcagcgttag cagcgcccct 780 cttaacaagc cgacccccac cagcgtcgcg gttactaaca ctcctctccc cggggcatcc 840 gctactcccg agctcacgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc 900 caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg 960 gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca 1020 tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc 1080 ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt 1140 attagtcatc gctattacca tggtcgaggt gagccccacg ttctgcttca ctctccccat 1200 ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat tttgtgcagc 1260 gatgggggcg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg 1320 gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc 1380 cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg 1440 gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc 1500 cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc 1560 cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa 1620 gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg 1680 tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct 1740 gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg 1800 gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt 1860 gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc 1920 cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg 1980 gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg 2040 ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg 2100 gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc 2160 agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc 2220 cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg 2280 gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc 2340 ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga 2400 ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc 2460 tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc ggcttgatcg 2520 aagccgtctc aggggagaga ccacacccaa gctgtctaga gccgccacct tatattcccc 2580 agaacatcag gttaatggcg tttttgatgt cattttcgcg gtggctgaga tcagccactt 2640 cttccccgat aacggaaacc ggcacactgg ccatatcggt ggtcatcatg cgccagcttt 2700 catccccgat atgcaccacc gggtaaagtt cacgggagac tttatctgac agcagacgtg 2760 cactggccag ggggatcacc atccgtcgcc cgggcgtgtc aataatatca ctctgtacat 2820 ccacaaacag acgataacgg ctctctcttt tataggtgta aaccttaaac tgcatttcac 2880 cagcccctgt tctcgtcagc aaaagagccg ttcatttcaa taaaccgggc gacctcagcc 2940 atcccttcct gattttccgc tttccagcgt tcggcacgca gacgacgggc ttcattctgc 3000 atggttgtgc ttaccagacc ggagatattg acatcatata tgccttgagc aactgatagc 3060 tgtcgctgtc aactgtcact gtaatacgct gcttcatagc atacctcttt ttgacatact 3120 tcgggtatac atatcagtat atattcttat accgcaaaaa tcagcgcgca aatacgcata 3180 ctgttatctg gcttttagta agccgacgca ctttgcgccg aataaatacc tgtgacggaa 3240 gatcacttcg cagaataaat aaatcctggt gtccctgttg ataccgggaa gccctgggcc 3300 aacttttggc gaaaatgaca cgttgatcgg cacgtaagag gttccaactt tcaccataat 3360 gaaataagat cactaccggg cgtatttttt gagttatcga gattttcagg agctaaggaa 3420 gctaaaatgg agaaaaaaat cactggatat accaccgttg atatatccca atggcatcgt 3480 aaagaacatt ttgaggcatt tcagtcagtt gctcaatgta cctataacca gaccgttcag 3540 ctggatatta cggccttttt aaagaccgta aagaaaaata agcacaagtt ttatccggcc 3600 tttattcaca ttcttgcccg cctgatgaat gctcatccgg agttccgtat ggcaatgaaa 3660 gacggtgagc tggtgatatg ggatagtgtt cacccttgtt acaccgtttt ccatgagcaa 3720 actgaaacgt tttcatcgct ctggagtgaa taccacgacg atttccggca gtttctacac 3780 atatattcgc aagatgtggc gtgttacggt gaaaacctgg cctatttccc taaagggttt 3840 attgagaata tgtttttcgt gtcagccaat ccctgggtga gtttcaccag ttttgattta 3900 aacgtggcca atatggacaa cttcttcgcc cccgttttca ctatgggcaa atattatacg 3960 caaggcgaca aggtgctgat gccgctggcg attcaggttc atcatgccgt ttgtgatggc 4020 ttccatgtcg gcagaatgct taatgaatta caacagtact gcgatgagtg gcaggggggg 4080 cgtaaacgcc gtgaggtctc taaaactgtc ttc 4113 <210> 760 <211> 2436 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 760 cttgctcacc tcgagtacga tagccggcta atcagccata ccacatttgt agaggtttta 60 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 120 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 180 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 240 aatgtatctt atcatgtctg gaattcggac ggtgactgca gtgaataata aaatgtgtgt 300 ttgtccgaaa tacgcgtttt gagatttctc tggagacgct gtcgccgact aaattcatgt 360 cgcgcgatag tggtgtttat cgccgataga gatggcgata ttggaaaaat cgatatttga 420 aaatatggca tattgaaaat gtcgccgatg tgagtttctg tgtaactgat atcgccattt 480 ttccaaaagt gatttttggg catacgcgat atctggcgat agcgcttata tcgtttacgg 540 gggatggcga tagacgactt tggtgacttg ggcgattctg tgtgtcgcaa atatcgcagt 600 ttcgatatag gtgacagacg atatgaggct atatcgccga tagaggcgac atcaagctgg 660 cacatggcca atgcatatcg atctatacat tgaatcaata ttggccatta gccatattat 720 tcattggtta tatagcataa atcaatattg gctattggcc attgcatacg ttgtatccat 780 atcataatat gtacatttat attggctcat gtccaacatt accgccatgt tgacattgat 840 tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg 900 agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc 960 gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt 1020 gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc 1080 atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg 1140 cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg 1200 ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact 1260 cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa 1320 atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta 1380 ggcgtgtacg gtgggaggtc tatataagca gagctcgttt agtgaaccgt cagatcgcct 1440 ggagaggcca tccacgctgt tttgacctcc atagtggaca ccgggaccga tccagcctcc 1500 gcggccggga acggtgcatt ggaacgcgga ttccccgtgc caagagtgac gtaagtaccg 1560 cctatagagt ctataggccc acccccttgg cttcttatgc atgctatact gtttttggct 1620 tggggtctat acacccccgc ttcctcatgt tataggtgat ggtatagctt agcctatagg 1680 tgtgggttat tgaccattat tgaccactcc cctattggtg acgatacttt ccattactaa 1740 tccataacat ggctctttgc cacaactctc tttattggct atatgccaat acactgtcct 1800 tcagagactg acacggactc tgtattttta caggatgggt tctcatttat tatttacaaa 1860 ttcacatata caacaccacc gtccccagtg cccgcagttt ttattaaaca taacgtggga 1920 tctccacgcg aatctcgggt acgtgttccg gacatgggtt cttctccggt agcggcggag 1980 cttctacatc cgagccctgc tcccatgcct ccagcgactc atggtcgctc ggcagctcct 2040 tgctcctaac agtggaggcc agacttaggc acagcacgat gcccaccacc accagtgtgc 2100 cgcacaaggc cgtggcggta gggtatgtgt ctgaaaatga gctcggggag cgggcttgca 2160 ccgctgacgc atttgaaaga cttaaggcag cggcagaaga agatgcaggc agctgagttg 2220 ttgtgttctg ataagagtca gaggtaactc ccgttgcggt gctgttaacg gtggagggca 2280 gtgtagtctg agcagtactc gttgctgccg cgcgcgccac cagacataat agctgacaga 2340 ctaacagact gttcctttcc atgggtcttt tctgcagtca ccgtccttga cacgcgtctc 2400 aggggcgtgt cgtgaaaact acccctagcc gccacc 2436 <210> 761 <211> 2042 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 761 atattatccc taatacttgc caccccactc ttaatcagtg gtggaagaac ggtgtcagaa 60 ctgtttgttt caattggcca tttaagttta gtagtaaaag actggttaat gataacaatg 120 catcgtaaaa ccttcagaag gaaaggagaa tgttttgtgg accactttgg ttttcttttt 180 tgcgtgtggc agttttaagt tattagtttt taaaatcagt actttttaat ggaaacaact 240 tgaccaaaaa tttgtcacag aattttgaga tccattaaaa aagttaaatg agaaacctgt 300 gtgttccttt ggtcaacacc gagacattta ggtgaaagca tatactgaga ttgagattaa 360 cttcctgtga aacccagtgt cttagacaac tgtggcttga gcaccacctg ttggtattca 420 ttacaaactt gctcactaca ataaatgaat tttaagcttt aagatgaagt ggcatttctt 480 ttaacagtta ctatgttgga attggttaca aattttggag tggactattg tatatatata 540 tcagttactg ttatggatcc cacgtcacta ttgtatactc tatattatac tctatgttat 600 actctgtaat cctactcaat aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg 660 tcttgttatc accatcaggt gacatcctcg cccaggctgt caatcatgcc ggtatcgatt 720 ccagtagcac cggccccacg ctgacaaccc actcttgcag cgttagcagc gcccctctta 780 acaagccgac ccccaccagc gtcgcggtta ctaacactcc tctccccggg gcatccgcta 840 ctcccgagct cctctggaga cggtagcatc cttaggatcg agtcaatggg aaaaacccat 900 tggagccaag tacactgact caatagggac tttccattgg gttttgccca gtacataagg 960 tcaatagggg gtgagtcaac aggaaagtcc cattggagcc aagtacattg agtcaatagg 1020 gactttccaa tgggttttgc ccagtacata aggtcaatgg gaggtaagcc aatgggtttt 1080 tcccattact gacatgtata ctgagtcatt agggactttc caatgggttt tgcccagtac 1140 ataaggtcaa taggggtgaa tcaacaggaa agtcccattg gagccaagta cactgagtca 1200 atagggactt tccattgggt tttgcccagt acaaaaggtc aatagggggt gagtcaatgg 1260 gtttttccca ttattggcac gtacataagg tcaatagggg tgagtcattg ggtttttcca 1320 gccaatttat aaaacgccat gtactttccc accattgacg tcaatgggct attgaaacta 1380 atgcaacgtg acctttaaac ggtactttcc catagctgat taatgggaaa gtaccgttct 1440 cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt 1500 ttcccctgga aattccatat tggcacgcat tctattggct gagctgcgtt ctacgtgggt 1560 ataagaggcg cgaccagcgt cggtaccgtc gcagtcttgg gtctgaccac cgtagaacgc 1620 agagctcctc gctgctcaga tcgcctggag aggccatcca cgctgttttg acctccatag 1680 tggacaccgg gaccgatcca gcctccgcgg ccgggaacgg tgcattggaa cgcggattcc 1740 ccgtgccaag agtgacgtaa gtctgttgac atgtatgtga tgtatactaa tctgcatggg 1800 acgtggattt acttgtgtat gtcagataga gtaaagatta actcttgcat gtgagcgggg 1860 catcgagata gcgataaatg agtcaggagg acggatactt atatgtgttg ttatcctcct 1920 ctacagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc tccgtctcag 1980 gggcaagctt gcttgttctt tttgcagaag ctcagaataa acgctcaact ttggccgcca 2040 cc 2042 <210> 762 <211> 1836 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 762 ccgcctagga ctgtatactc tatattatac tctatgttat actctgtaat cctactcaat 60 aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg tcttcttatc accatcaggt 120 gacatcctcg cccaggctgt caatcatgcc ggtatcgatt ccagtagcac cggccccacg 180 ctgacaaccc actcttgcag cgttagcagc gcccctctta acaagccgac ccccaccagc 240 gtcgcggtta ctaacactcc tctccccggg gcatccgcta ctcccgagct cgaattcgtt 300 tatcggccac cgaggccaag atctggccgc catatactga gtcattaggg actttccaat 360 gggttttgcc cagtacataa ggtcaatagg ggtgaatcaa caggaaagtc ccattggagc 420 caagtacact gagtcaatag ggactttcca ttgggttttg cccagtacaa aaggtcaata 480 gggggtgagt caatgggttt ttcccattat tggcacgtac ataaggtcaa taggggtgag 540 tcattgggtt tttccagcca atttataaaa cgccatgtac tttcccacca ttgacgtcaa 600 tgggctattg aaactaatgc aacgtgacct ttaaacggta ctttcccata gctgattaat 660 gggaaagtac cgttctcgag ccaatacacg tcaatgggaa gtgaaagggc agccaaaacg 720 taacaccgcc ccggttttcc cctggaaatt ccatattggc acgcattcta ttggctgagc 780 tgcgttctac gtgggtataa gaggcgcgac cagcgtcggt agggaccggt ttgccgccag 840 aacacaggtg aggggcgggt gtggcttccg cgggccgccg agctggaggt cctgctccga 900 gcgggccggg ccccgctgtc gtcggcgggg attagctgcg agcattcccg cttcgagttg 960 cgggcggcgc gggaggcaga gtgcgaggcc tagcggcaac cccgtagcct cgcctcgtgt 1020 ccggcttgag gcctagcgtg gtgtccgcgc cgccgccgcg tgctactccg gccgcactct 1080 ggtctttttt ttttttgttg ttgttgccct gctgccttcg attgccgttc agcaataggg 1140 gctaacaaag ggagggtgcg gggcttgctc gcccggagcc cggagaggtc atggttgggg 1200 aggaatggag ggacaggagt ggcggctggg gcccgcccgc cttcggagca catgtccgac 1260 gccacctgga tggggcgagg cctggggttt ttcccgaagc aaccaggctg gggttagcgt 1320 gccgaggcca tgtggcccca gcacccggca cgatctggct tggcggcgcc gcgttgccct 1380 gcctccctaa ctagggtgag gccatcccgt ccggcaccag ttgcgtgcgt ggaaagatgg 1440 ccgctcccgg gccctgttgc aaggagctca aaatggagga cgcggcagcc cggtggagcg 1500 ggcgggtgag tcacccacac aaaggaagag ggcctggtcc ctcaccggct gctgcttcct 1560 gtgaccccgt ggtcctatcg gccgcaatag tcacctcggg cttttgagca cggctagtcg 1620 cggcgggggg aggggatgta atggcgttgg agtttgttca catttggtgg gtggagacta 1680 gtcaggccag cctggcgctg gaagtcattt ttggaatttg tccccttgag ttttgagcgg 1740 agctaattct cgggcttctt agcggttcaa aggtatcttt taaacccttt tttaggtgtt 1800 gtgaaaacca ccgctaattc aaagcaagcc gccacc 1836 <210> 763 <211> 1923 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 763 ccgcctagga ctgtatactc tatattatac tctatgttat actctgtaat cctactcaat 60 aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg tcttcttatc accatcaggt 120 gacatcctcg cccaggctgt caatcatgcc ggtatcgatt ccagtagcac cggccccacg 180 ctgacaaccc actcttgcag cgttagcagc gcccctctta acaagccgac ccccaccagc 240 gtcgcggtta ctaacactcc tctccccggg gcatccgcta ctcccgagct cgaattcgtt 300 tatcggccac cgaggccaag atctggccgc caacttacgg taaatggccc gcctggctga 360 ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca 420 atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca 480 gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga cggtaaatgg 540 cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg gcagtacatc 600 tacgtattag tcatcgctat taccaagtca ttgggttttt ccagccaatt tataaaacgc 660 catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac gtgaccttta 720 aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca atacacgtca 780 atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttcccct ggaaattcca 840 tattggcacg cattctattg gctgagctgc gttctacgtg ggtataagag gcgcgaccag 900 cgtcggtagg gaccggtttg ccgccagaac acaggtgagg ggcgggtgtg gcttccgcgg 960 gccgccgagc tggaggtcct gctccgagcg ggccgggccc cgctgtcgtc ggcggggatt 1020 agctgcgagc attcccgctt cgagttgcgg gcggcgcggg aggcagagtg cgaggcctag 1080 cggcaacccc gtagcctcgc ctcgtgtccg gcttgaggcc tagcgtggtg tccgcgccgc 1140 cgccgcgtgc tactccggcc gcactctggt cttttttttt tttgttgttg ttgccctgct 1200 gccttcgatt gccgttcagc aataggggct aacaaaggga gggtgcgggg cttgctcgcc 1260 cggagcccgg agaggtcatg gttggggagg aatggaggga caggagtggc ggctggggcc 1320 cgcccgcctt cggagcacat gtccgacgcc acctggatgg ggcgaggcct ggggtttttc 1380 ccgaagcaac caggctgggg ttagcgtgcc gaggccatgt ggccccagca cccggcacga 1440 tctggcttgg cggcgccgcg ttgccctgcc tccctaacta gggtgaggcc atcccgtccg 1500 gcaccagttg cgtgcgtgga aagatggccg ctcccgggcc ctgttgcaag gagctcaaaa 1560 tggaggacgc ggcagcccgg tggagcgggc gggtgagtca cccacacaaa ggaagagggc 1620 ctggtccctc accggctgct gcttcctgtg accccgtggt cctatcggcc gcaatagtca 1680 cctcgggctt ttgagcacgg ctagtcgcgg cggggggagg ggatgtaatg gcgttggagt 1740 ttgttcacat ttggtgggtg gagactagtc aggccagcct ggcgctggaa gtcatttttg 1800 gaatttgtcc ccttgagttt tgagcggagc taattctcgg gcttcttagc ggttcaaagg 1860 tatcttttaa accctttttt aggtgttgtg aaaaccaccg ctaattcaaa gcaagccgcc 1920 acc 1923 <210> 764 <211> 2494 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 764 ccgcctagga catattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 60 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 120 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 180 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 240 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 300 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag 360 attgagatta acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct 420 gttggtattc attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag 480 tggcatttct tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt 540 gtatatatat atcagttact gttatggatc ccacgtcact attgtatact ctatattata 600 ctctatgtta tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta 660 agtctcccgt gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc 720 cggtatcgat tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag 780 cgcccctctt aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg 840 ggcatccgct actcccgagc tcgaattcgt ttatcggcca ccgaggccaa gatctggccg 900 ccaacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 960 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 1020 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc 1080 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 1140 cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccaagtc 1200 attgggtttt tccagccaat ttataaaacg ccatgtactt tcccaccatt gacgtcaatg 1260 ggctattgaa actaatgcaa cgtgaccttt aaacggtact ttcccatagc tgattaatgg 1320 gaaagtaccg ttctcgagcc aatacacgtc aatgggaagt gaaagggcag ccaaaacgta 1380 acaccgcccc ggttttcccc tggaaattcc atattggcac gcattctatt ggctgagctg 1440 cgttctacgt gggtataaga ggcgcgacca gcgtcggtag ggaccggttt gccgccagaa 1500 cacaggtgag gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc tgctccgagc 1560 gggccgggcc ccgctgtcgt cggcggggat tagctgcgag cattcccgct tcgagttgcg 1620 ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc 1680 ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc cgcactctgg 1740 tctttttttt ttttgttgtt gttgccctgc tgccttcgat tgccgttcag caataggggc 1800 taacaaaggg agggtgcggg gcttgctcgc ccggagcccg gagaggtcat ggttggggag 1860 gaatggaggg acaggagtgg cggctggggc ccgcccgcct tcggagcaca tgtccgacgc 1920 cacctggatg gggcgaggcc tggggttttt cccgaagcaa ccaggctggg gttagcgtgc 1980 cgaggccatg tggccccagc acccggcacg atctggcttg gcggcgccgc gttgccctgc 2040 ctccctaact agggtgaggc catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc 2100 gctcccgggc cctgttgcaa ggagctcaaa atggaggacg cggcagcccg gtggagcggg 2160 cgggtgagtc acccacacaa aggaagaggg cctggtccct caccggctgc tgcttcctgt 2220 gaccccgtgg tcctatcggc cgcaatagtc acctcgggct tttgagcacg gctagtcgcg 2280 gcggggggag gggatgtaat ggcgttggag tttgttcaca tttggtgggt ggagactagt 2340 caggccagcc tggcgctgga agtcattttt ggaatttgtc cccttgagtt ttgagcggag 2400 ctaattctcg ggcttcttag cggttcaaag gtatctttta aacccttttt taggtgttgt 2460 gaaaaccacc gctaattcaa agcaagccgc cacc 2494 <210> 765 <211> 901 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 765 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc ggccgccata tactgagtca 300 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 360 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 420 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 480 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc 540 ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt 600 cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga 660 aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc 720 attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaccg 780 tcgcagtctt gggtctgacc accgtagaac gcagagctcc tcgctgcagt atcctgccca 840 agaaagagcg acccgtctca ggggcttcgc aggtacaccc aagctgtcta gagccgccac 900 c 901 <210> 766 <211> 1545 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 766 ccgcctagga catattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 60 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 120 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 180 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 240 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 300 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag 360 attgagatta acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct 420 gttggtattc attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag 480 tggcatttct tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt 540 gtatatatat atcagttact gttatggatc ccacgtcact attgtatact ctatattata 600 ctctatgtta tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta 660 agtctcccgt gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc 720 cggtatcgat tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag 780 cgcccctctt aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg 840 ggcatccgct actcccgagc tcgaattcgt ttatcggcca ccgaggccaa gatctggccg 900 ccaacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 960 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 1020 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc 1080 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 1140 cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatgct 1200 gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc 1260 aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt 1320 tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg 1380 ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gaggccatcc 1440 acgctgtttt gacctccata gtggacaccg ggaccgatcc agcctccgag cttgcttgtt 1500 ctttttgcag aagctcagaa taaacgctca actttggccg ccacc 1545 <210> 767 <211> 2101 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 767 ccgcctagga catattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 60 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 120 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 180 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 240 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 300 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag 360 attgagatta acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct 420 gttggtattc attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag 480 tggcatttct tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt 540 gtatatatat atcagttact gttatggatc ccacgtcact attgtatact ctatattata 600 ctctatgtta tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta 660 agtctcccgt gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc 720 cggtatcgat tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag 780 cgcccctctt aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg 840 ggcatccgct actcccgagc tcgaattcgt ttatcggcca ccgaggccaa gatctggccg 900 ccagcacatc gcccacagtc cccgagaagt tgggaggggt cggcaattga accggtgcct 960 agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc 1020 ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca 1080 acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct 1140 ttacgggtta tggcccttgc gtgccttgaa ttacttccac ctggctccag tacgtgattc 1200 ttgatcccga gctggagcca ggggcgggcc ttgcgcttta ggagcccctt cgcctcgtgc 1260 ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg 1320 cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacgtgctgc 1380 gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caggatctgc acactggtat 1440 ttcggttttt gggcccgcgg ccggcgacgg ggcccgtgcg tcccagcgca catgttcggc 1500 gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg 1560 gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct 1620 ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctccagg 1680 gggctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag 1740 gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt accgggcgcc 1800 gtccaggcac ctcgattagt tctggagctt ttggagtacg tcgtctttag gttgggggga 1860 ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc 1920 ttggcacttg atgtaattct ccttggaatt tggccttttt gagtttggat cttggttcat 1980 tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgaacacc 2040 atctattgct tacatttgct tctgacacaa ctgtgttcac tagcaacctc aaacagacac 2100 c 2101 <210> 768 <211> 2485 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 768 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag atagactctg ggtagaatgt tctgtttcct 420 gtaatataaa atcataaagt gatgatatta tcaagtgaaa aggaaatgtg gtaccttaat 480 ctttccacat caagccaata tcatgctgaa ggccagagaa tcttttttgc taaaaaacac 540 aatacagata taattaatag ttatcattta tgtttgatat taatcatatg aatataatta 600 atatgtttta ttgtatcgat tattgttgat attaatgtaa ttactactaa tacataacaa 660 atataactaa tggttatggc tcagtaacta aggtaagata taagctacac tggtaaagaa 720 agatcaatat tgcttcagag tacactgaag taaatgaata acttaaccgg tctaggttgt 780 cacttatatt tatacgaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 840 gcccgtcagt gacctgctat agaaacttga tctgtcgccg caattcaagc ttcgtgaggc 900 tccggtgccc gtcagtgacc tgctatactc tgagcggggc tgacgtcggg aggtggcctc 960 cgtgggaagg gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg 1020 atagattctg gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag 1080 agtaattcat acaaaaggag ggatcgcctt cgcaagggga gagcccaggg accgtcccta 1140 aattctcaca gacccaaatc cctgtagccg ccccacgaca gcgcgaggag catgcgctca 1200 gggctgagcg cggggagagc agagcacaca agctcataga ccctggtcgt gggggggagg 1260 accggggagc tggcgcgggg caaactggga aagcggtgtc gtgtgctggc tccgccctct 1320 tcccgagggt gggggagaac ggtatataag tgcggcagtc gccttggacg ttctttttcg 1380 caacgggttt gccgtcagaa cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag 1440 ctggaggtcc tgctccgagc gggccgggcc ccgctgtcgt cggcggggat tagctgcgag 1500 cattcccgct tcgagttgcg ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc 1560 cgtagcctcg cctcgtgtcc ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg 1620 ctactccggc cgcactctgg tctttttttt ttttgttgtt gttgccctgc tgccttcgat 1680 tgccgttcag caataggggc taacaaaggg agggtgcggg gcttgctcgc ccggagcccg 1740 gagaggtcat ggttggggag gaatggaggg acaggagtgg cggctggggc ccgcccgcct 1800 tcggagcaca tgtccgacgc cacctggatg gggcgaggcc tggggttttt cccgaagcaa 1860 ccaggctggg gttagcgtgc cgaggccatg tggccccagc acccggcacg atctggcttg 1920 gcggcgccgc gttgccctgc ctccctaact agggtgaggc catcccgtcc ggcaccagtt 1980 gcgtgcgtgg aaagatggcc gctcccgggc cctgttgcaa ggagctcaaa atggaggacg 2040 cggcagcccg gtggagcggg cgggtgagtc acccacacaa aggaagaggg cctggtccct 2100 caccggctgc tgcttcctgt gaccccgtgg tcctatcggc cgcaatagtc acctcgggct 2160 tttgagcacg gctagtcgcg gcggggggag gggatgtaat ggcgttggag tttgttcaca 2220 tttggtgggt ggagactagt caggccagcc tggcgctgga agtcattttt ggaatttgtc 2280 cccttgagtt ttgagcggag ctaattctcg ggcttcttag cggttcaaag gtatctttta 2340 aacccttttt taggtgttgt gaaaaccacc gctaattcaa agcaagcagg agcccgggct 2400 gggcataaaa gtcagggcag agccatctat tgcttacatt tgcttctgac acaactgtgt 2460 tcactagcaa cctcaaacag acacc 2485 <210> 769 <211> 2772 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 769 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag atagactctg ggtagaatgt tctgtttcct 420 gtaatataaa atcataaagt gatgatatta tcaagtgaaa aggaaatgtg gtaccttaat 480 ctttccacat caagccaata tcatgctgaa ggccagagaa tcttttttgc taaaaaacac 540 aatacagata taattaatag ttatcattta tgtttgatat taatcatatg aatataatta 600 atatgtttta ttgtatcgat tattgttgat attaatgtaa ttactactaa tacataacaa 660 atataactaa tggttatggc tcagtaacta aggtaagata taagctacac tggtaaagaa 720 agatcaatat tgcttcagag tacactgaag taaatgaata acttaaccgg tctaggttgt 780 cacttatatt tatacaacat tttaagaact aagaacctct cttctatgct tagtagatga 840 acaaaatcat gtaatagatg aatgaggcca ggaagtacaa aggtttacaa aattgccaag 900 ccactctggg gtgattttat gagtaatgcg gcatttggta gcttgcctta aagaatatta 960 ttggacatta tcaagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtaactgaac 1020 tctcttgtag tttcattttt gtttgaaaaa gacatgtatc tcatgtagcc caggctggaa 1080 tcgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc cgtcagtgac 1140 ctgctataga aacttgatct gtcgccgcaa ttcaagcttc gtgaggctcc ggtgcccgtc 1200 agtgacctgc tatactctga gcggggctga cgtcgggagg tggcctccgt gggaagggac 1260 acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata gattctggcc 1320 gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt aattcataca 1380 aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat tctcacagac 1440 ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgctcaggg ctgagcgcgg 1500 ggagagcaga gcacacaagc tcatagaccc tggtcgtggg ggggaggacc ggggagctgg 1560 cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc gccctcttcc cgagggtggg 1620 ggagaacggt atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa cgggtttgcc 1680 gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg gaggtcctgc 1740 tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat tcccgcttcg 1800 agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt agcctcgcct 1860 cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta ctccggccgc 1920 actctggtct tttttttttt tgttgttgtt gccctgctgc cttcgattgc cgttcagcaa 1980 taggggctaa caaagggagg gtgcggggct tgctcgcccg gagcccggag aggtcatggt 2040 tggggaggaa tggagggaca ggagtggcgg ctggggcccg cccgccttcg gagcacatgt 2100 ccgacgccac ctggatgggg cgaggcctgg ggtttttccc gaagcaacca ggctggggtt 2160 agcgtgccga ggccatgtgg ccccagcacc cggcacgatc tggcttggcg gcgccgcgtt 2220 gccctgcctc cctaactagg gtgaggccat cccgtccggc accagttgcg tgcgtggaaa 2280 gatggccgct cccgggccct gttgcaagga gctcaaaatg gaggacgcgg cagcccggtg 2340 gagcgggcgg gtgagtcacc cacacaaagg aagagggcct ggtccctcac cggctgctgc 2400 ttcctgtgac cccgtggtcc tatcggccgc aatagtcacc tcgggctttt gagcacggct 2460 agtcgcggcg gggggagggg atgtaatggc gttggagttt gttcacattt ggtgggtgga 2520 gactagtcag gccagcctgg cgctggaagt catttttgga atttgtcccc ttgagttttg 2580 agcggagcta attctcgggc ttcttagcgg ttcaaaggta tcttttaaac ccttttttag 2640 gtgttgtgaa aaccaccgct aattcaaagc aagcaggagc ccgggctggg cataaaagtc 2700 agggcagagc catctattgc ttacatttgc ttctgacaca actgtgttca ctagcaacct 2760 caaacagaca cc 2772 <210> 770 <211> 2831 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 770 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagctggact ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcgggg gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta 780 tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc 840 ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca ttggggccaa 900 tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg 960 ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat atggtagggt 1020 tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg agtcgggcgc 1080 gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac agcccccccc 1140 caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag cgagccgccc 1200 ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg tgcggggaca 1260 gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct cgctgctctt 1320 tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa gagagattta 1380 gaatgacagg caacctttgg agctaagcca gcaatggtag agggaagatt ctgcacgtcc 1440 cttccaggcg gcctccccgt caccaccccc cccaacccgc cccgaccgga gctgagagta 1500 attcatacaa aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc 1560 actaacgtag aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat 1620 cactgaggtg gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca 1680 tcgcccacag tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga 1740 aggtggcgcg gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag 1800 ggtgggggag aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg 1860 tttgccgcca gaacacaggt aagtgccgtg tgtggttccc gcgggcctgg cctctttacg 1920 ggttatggcc cttgcgtgcc ttgaattact tccacctggc tccagtacgt gattcttgat 1980 cccgagctgg agccaggggc gggccttgcg ctttaggagc cccttcgcct cgtgcttgag 2040 ttgaggcctg gcctgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct 2100 gtctcgctgc tttcgataag tctctagcca tttaaaattt ttgatgacgt gctgcgacgc 2160 tttttttctg gcaagatagt cttgtaaatg cgggccagga tctgcacact ggtatttcgg 2220 tttttgggcc cgcggccggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc 2280 ggggcctgcg agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg 2340 ctctggtgcc tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc 2400 ggtcggcacc agttgcgtga gcggaaagat ggccgcttcc cggccctgct ccagggggct 2460 caaaatggag gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaaa 2520 gggcctttcc gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca 2580 ggcacctcga ttagttctgg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt 2640 tttatgcgat ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc 2700 acttgatgta attctccttg gaatttggcc tttttgagtt tggatcttgg ttcattctca 2760 agcctcagac agtggttcaa agtttttttc ttccatttca ggtgtcgtga aaactacccc 2820 taaaagccac c 2831 <210> 771 <211> 2890 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 771 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagctggact ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcgggg gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta 780 tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc 840 ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca ttggggccaa 900 tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg 960 ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat atggtagggt 1020 tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg agtcgggcgc 1080 gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac agcccccccc 1140 caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag cgagccgccc 1200 ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg tgcggggaca 1260 gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct cgctgctctt 1320 tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa gagagattta 1380 gaatgacagc ctctcccggc cagaggagca aggtatgcgg gaggcgacca ggaggatagc 1440 ggggctgacg tcgggaggtg gcctccgtgg gaaggacacc cggatcttga cacagccttg 1500 gcagcggagt caggaagagt aggggtaggt tctggacgcc ctcttggcca gctcatcgcc 1560 gccccaccct ctgctggagc acagagtaat tcatacaaaa ggagggatcg ccttcgcaag 1620 gggagagccc agggaccgtc cctaaattct cacagaccca aatccctgta gccgccccac 1680 gacagcgcga ggagcatgcg cccagggctg agcgcgggta gatcagagca cacaagctca 1740 cagtccccgg cggtgggggg aggggcgcgc tgagcggggg ccagggagct ggcgcggggc 1800 aaactgggaa agtggtgtcg tgtgctggct ccgccctctt cccgagggtg ggggagaacg 1860 gtatataagt gcggtagtcg ccttggacgt tctttttcgc aacgggtttg ccgtcagaac 1920 gcaggtgagt ggcgggtgtg gcttccgcgg gccccggagc tggagccctg ctctgagcgg 1980 gccgggctga tatgcgagtg tcgtccgcag ggtttagctg tgagcattcc cacttcgagt 2040 ggcgggcggt gcgggggtga gagtgcgagg cctagcggca accccgtagc ctcgcctcgt 2100 gtccggcttg aggcctagcg tggtgtccgc cgccgcgtgc cactccggcc gcactatgcg 2160 ttttttgtcc ttgctgccct cgattgcctt ccagcagcat gggctaacaa agggagggtg 2220 tggggctcac tcttaaggag cccatgaagc ttacgttgga taggaatgga agggcaggag 2280 gggcgactgg ggcccgcccg ccttcggagc acatgtccga cgccacctgg atggggcgag 2340 gcctgtggct ttccgaagca atcgggcgtg agtttagcct acctgggcca tgtggcccta 2400 gcactgggca cggtctggcc tggcggtgcc gcgttccctt gcctcccaac aagggtgagg 2460 ccgtcccgcc cggcaccagt tgcttgcgcg gaaagatggc cgctcccggg gccctgttgc 2520 aaggagctca aaatggagga cgcggcagcc cggtggagcg ggcgggtgag tcacccacac 2580 aaaggaagag ggccttgccc ctcgccggcc gctgcttcct gtgaccccgt ggtctatcgg 2640 ccgcatagtc acctcgggct tctcttgagc accgctcgtc gcggcggggg gaggggatct 2700 aatggcgttg gagtttgttc acatttggtg ggtggagact agtcaggcca gcctggcgct 2760 ggaagtcatt cttggaattt gcccctttga gtttggagcg aggctaattc tcaagcctct 2820 tagcggttca aaggtatttt ctaaacccgt ttccaggtgt tgtgaaagcc accgctaatt 2880 caaagcaacc 2890 <210> 772 <211> 2844 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 772 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagctggact ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcgggg gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta 780 tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc 840 ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca ttggggccaa 900 tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg 960 ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat atggtagggt 1020 tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg agtcgggcgc 1080 gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac agcccccccc 1140 caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag cgagccgccc 1200 ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg tgcggggaca 1260 gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct cgctgctctt 1320 tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa gagagattta 1380 gaatgacaga gcggggctga cgtcgggagg tggcctccgt gggaagggac acccggatct 1440 tgacacagcc ttggcagcgg agtaaggaag agtagggata gattctggcc gccctcttgg 1500 ccagcttctc gccgccccac cctccgctag ggccaagagt aattcataca aaaggaggga 1560 tcgccttcgc aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct 1620 gtagccgccc cacgacagcg cgaggagcat gcgctcaggg ctgagcgcgg ggagagcaga 1680 gcacacaagc tcatagaccc tggtcgtggg ggggaggacc ggggagctgg cgcggggcaa 1740 actgggaaag cggtgtcgtg tgctggctcc gccctcttcc cgagggtggg ggagaacggt 1800 atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa cgggtttgcc gtcagaacgc 1860 aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg gaggtcctgc tccgagcggg 1920 ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat tcccgcttcg agttgcgggc 1980 ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt agcctcgcct cgtgtccggc 2040 ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta ctccggccgc actctggtct 2100 tttttttttt tgttgttgtt gccctgctgc cttcgattgc cgttcagcaa taggggctaa 2160 caaagggagg gtgcggggct tgctcgcccg gagcccggag aggtcatggt tggggaggaa 2220 tggagggaca ggagtggcgg ctggggcccg cccgccttcg gagcacatgt ccgacgccac 2280 ctggatgggg cgaggcctgg ggtttttccc gaagcaacca ggctggggtt agcgtgccga 2340 ggccatgtgg ccccagcacc cggcacgatc tggcttggcg gcgccgcgtt gccctgcctc 2400 cctaactagg gtgaggccat cccgtccggc accagttgcg tgcgtggaaa gatggccgct 2460 cccgggccct gttgcaagga gctcaaaatg gaggacgcgg cagcccggtg gagcgggcgg 2520 gtgagtcacc cacacaaagg aagagggcct ggtccctcac cggctgctgc ttcctgtgac 2580 cccgtggtcc tatcggccgc aatagtcacc tcgggctttt gagcacggct agtcgcggcg 2640 gggggagggg atgtaatggc gttggagttt gttcacattt ggtgggtgga gactagtcag 2700 gccagcctgg cgctggaagt catttttgga atttgtcccc ttgagttttg agcggagcta 2760 attctcgggc ttcttagcgg ttcaaaggta tcttttaaac ccttttttag gtgttgtgaa 2820 aaccaccgct aattcaaagc aacc 2844 <210> 773 <211> 2858 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 773 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cagctggact ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagta tacatcgttt ccatggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcgggg gaggctaact gaaacacgga aggagacaat accggaagga acccgcgcta 780 tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc 840 ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca ttggggccaa 900 tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga aggcccaggg 960 ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat atggtagggt 1020 tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg agtcgggcgc 1080 gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac agcccccccc 1140 caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag cgagccgccc 1200 ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg tgcggggaca 1260 gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct cgctgctctt 1320 tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa gagagattta 1380 gaatgacaga cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt 1440 gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca 1500 atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc 1560 aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta 1620 catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac 1680 cagcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc 1740 ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt 1800 tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg 1860 caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg ggcctggcct 1920 ctttacgggt tatggccctt gcgtgccttg aattacttcc acctggctcc agtacgtgat 1980 tcttgatccc gagctggagc caggggcggg ccttgcgctt taggagcccc ttcgcctcgt 2040 gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt 2100 cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacgtgct 2160 gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaggatct gcacactggt 2220 atttcggttt ttgggcccgc ggccggcgac ggggcccgtg cgtcccagcg cacatgttcg 2280 gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc 2340 cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg 2400 ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctcca 2460 gggggctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa 2520 aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg 2580 ccgtccaggc acctcgatta gttctggagc ttttggagta cgtcgtcttt aggttggggg 2640 gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca 2700 gcttggcact tgatgtaatt ctccttggaa tttggccttt ttgagtttgg atcttggttc 2760 attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcagac atttgcttct 2820 gacacaactg tgttcactag caacctcaaa cagacacc 2858 <210> 774 <211> 1083 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 774 attatcccta atacctgcca ccccactctt aatcagtggt ggaagaacgg tgtcagaact 60 gtttgtttca attggccatt taagtttagt agtaaaagac tggttaatga taacaatgca 120 tcgtaaaacc ttcagaagga aaggagaatg ttttgtggac cactttggtt ttcttttttg 180 cgtgtggcag ttttaagtta ttagttttta aaatcagtac tttttaatgg aaacaacttg 240 accaaaaatt tgtcacagaa ttttgacacc cattaaaaaa gttaaatgag aaacctgtgt 300 gttcctttgg agaggggcgg aagggacgtt aggagggagg cagggaggca gggaggcagg 360 gaggaacgga gggaggaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 420 gcccgtcagt gacctgctat aacttacggt aaatggcccg cctggctgac cgcccaacga 480 cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt 540 ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt 600 gtatcatatg ccaagtccgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca 660 ttatgcccag tacatgacct tacgggactt tcctacttgg cagtacatct acgtattagt 720 catcgctatt accatgctga tgcggttttg gcagtacacc aatgggcgtg gatagcggtt 780 tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca 840 ccaaaatcaa cgggactttc caaaatgtcg taataacccc gccccgttga cgcaaatggg 900 cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgtcagat 960 cgcctggaga ggccatccac gctgttttga cctccatagt ggacaccggg accgatccag 1020 cctccgagct tgcttgttct ttttgcagaa gctcagaata aacgctcaac tttggccgcc 1080 acc 1083 <210> 775 <211> 1503 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 775 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag atagactctg ggtagaatgt tctgtttcct 420 gtaatataaa atcataaagt gatgatatta tcaagtgaaa aggaaatgtg gtaccttaat 480 ctttccacat caagccaata tcatgctgaa ggccagagaa tcttttttgc taaaaaacac 540 aatacagata taattaatag ttatcattta tgtttgatat taatcatatg aatataatta 600 atatgtttta ttgtatcgat tattgttgat attaatgtaa ttactactaa tacataacaa 660 atataactaa tggttatggc tcagtaacta aggtaagata taagctacac tggtaaagaa 720 agatcaatat tgcttcagag tacactgaag taaatgaata acttaaccgg tctaggttgt 780 cacttatatt tatacgaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 840 gcccgtcagt gacctgctat aacttacggt aaatggcccg cctggctgac cgcccaacga 900 cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt 960 ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt 1020 gtatcatatg ccaagtccgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca 1080 ttatgcccag tacatgacct tacgggactt tcctacttgg cagtacatct acgtattagt 1140 catcgctatt accatgctga tgcggttttg gcagtacacc aatgggcgtg gatagcggtt 1200 tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca 1260 ccaaaatcaa cgggactttc caaaatgtcg taataacccc gccccgttga cgcaaatggg 1320 cggtaggcgt gtacggtggg aggtctatat aagcagagct cgtttagtga accgtcagat 1380 cgcctggaga ggccatccac gctgttttga cctccatagt ggacaccggg accgatccag 1440 cctccgagct tgcttgttct ttttgcagaa gctcagaata aacgctcaac tttggccgcc 1500 acc 1503 <210> 776 <211> 991 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 776 atctgtatac tctatattat actctatgtt atactctgta atcctactca ataaacgtgt 60 cacgcctgtg aaaccgtact aagtctcccg tgtcttctta tcaccatcag gtgacatcct 120 cgcccaggct gtcaatcatg ccggtatcga ttccagtagc accggcccca cgctgacaac 180 ccactcttgc agcgttagca gcgcccctct taacaagccg acccccacca gcgtcgcggt 240 tactaacact cctctccccg gggcatccgc tactcccgag ctcgaaactt gatctgtcgc 300 cgcaattcaa gcttcgtgag gctccggtgc ccgtcagtga cctgctataa cttacggtaa 360 atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg 420 ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt 480 aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc cctattgacg 540 tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta cgggactttc 600 ctacttggca gtacatctac gtattagtca tcgctattac catgctgatg cggttttggc 660 agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca 720 ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta 780 ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa 840 gcagagctcg tttagtgaac cgtcagatcg cctggagagg ccatccacgc tgttttgacc 900 tccatagtgg acaccgggac cgatccagcc tccgagcttg cttgttcttt ttgcagaagc 960 tcagaataaa cgctcaactt tggccgccac c 991 <210> 777 <211> 1476 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 777 cttgctcacc tcgagtacga tagccggcta atcagccata ccacatttgt agaggtttta 60 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 120 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 180 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 240 aatgtatctt atcatgtctg gaattcggac ggtgactgca gtgaataata aaatgtgtgt 300 ttgtccgaaa tacgcgtttt gagatttctc tggagtcgct gtcgccgact aaattcatgt 360 cgcgcgatag tggtgtttat cgccgataga gatggcgata ttggaaaaat cgatatttga 420 aaatatggca tattgaaaat gtcgccgatg tgagtttctg tgtaactgat atcgccattt 480 ttccaaaagt gatttttggg catacgcgat atctggcgat agcgcttata tcgtttacgg 540 gggatggcga tagacgactt tggtgacttg ggcgattctg tgtgtcgcaa atatcgcagt 600 ttcgatatag gtgacagacg atatgaggct atatcgccga tagaggcgac atcaagctgg 660 cacatggcca atgcatatcg atctatacat tgaatcaata ttggccatta gccatattat 720 tcattggtta tatagcataa atcaatattg gctattggcc attgcatacg ttgtatccat 780 atcataatat gtacatttat attggctcat gtccaacatt accgccatgt tgacacttac 840 ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac 900 gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt 960 acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc cgccccctat 1020 tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttacggga 1080 ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgc tgatgcggtt 1140 ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca 1200 ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg 1260 tcgtaataac cccgccccgt tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta 1320 tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agaggccatc cacgctgttt 1380 tgacctccat agtggacacc gggaccgatc cagcctccga gcttgcttgt tctttttgca 1440 gaagctcaga ataaacgctc aactttggcc gccacc 1476 <210> 778 <211> 2277 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 778 cttgctcacc tcgagtacga tagccggcta atcagccata ccacatttgt agaggtttta 60 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 120 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 180 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 240 aatgtatctt atcatgtctg gtattcggac ggtgacgata tttgaaaata tggcatattg 300 aaaatgtcgc cgatgtgagt ttctgtgtaa ctgatatcgc catttttcca aaagtgattt 360 ttgggcatac gcgatatctg gcgatagcgc ttatatcgtt tacgggggat ggcgatagac 420 gactttggtg acttgggcga ttctgtgtgt cgcaaatatc gcagtttcga tataggtgac 480 agacgatatg aggctatatc gccgatagag gcgacatcaa gctggcacat ggccaatgca 540 tatcgatcta tacattgaat caatattggc cattagccat attattcatt ggttatatag 600 cataaatcaa tattggctat tggccattgc atacgttgta tccatatcat aatatgtaca 660 tttatattgg ctcatgtcca acattaccgc catgttgaca ttgattattg actagttatt 720 aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 780 aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 840 taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 900 agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 960 cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1020 tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1080 tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1140 gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1200 caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1260 aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac 1320 gctgttttga cctccataga agataccggg accgatccag cctccgcggc cgggaacggt 1380 gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat agagtctata 1440 ggcccacccc cttggcttct tatgcatgct atactgtttt tggcttgggg tctatacacc 1500 cccgcttcct catgttatag gtgatggtat agcttagcct ataggtgtgg gttattgacc 1560 attattgacc actcccctat tggtgacgat actttccatt actaatccat aacatggctc 1620 tttgccacaa ctctctttat tggctatatg ccaatacact gtccttcaga gactgacacg 1680 gactctgtat ttttacagga tgggttctca tttattattt acaaattcac atatacaaca 1740 ccaccgtccc cagtgcccgc agtttttatt aaacataacg tgggatctcc acgcgaatct 1800 cgggtacgtg ttccggacat gggttcttct ccggtagcgg cggagcttct acatccgagc 1860 cctgctccca tgcctccagc gactcatggt cgctcggcag ctccttgctc ctaacagtgg 1920 aggccagact taggcacagc acgatgccca ccaccaccag tgtgccgcac aaggccgtgg 1980 cggtagggta tgtgtctgaa aatgagctcg gggagcgggc ttgcaccgct gacgcatttg 2040 aaagacttaa ggcagcggca gaagaagatg caggcagctg agttgttgtg ttctgataag 2100 agtcagaggt aactcccgtt gcggtgctgt taacggtgga gggcagtgta gtctgagcag 2160 tactcgttgc tgccgcgcgc gccaccagac ataatagctg acagactaac agactgttcc 2220 tttccatggg tcttttctgc agtcaccgtc cttgacacga agtttgctcg agccacc 2277 <210> 779 <211> 1698 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 779 cttgctcacc tcgagtacga tagccggcta atcagccata ccacatttgt agaggtttta 60 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 120 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 180 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 240 aatgtatctt atcatgtctg gtattcggac ggtgacgata tttgaaaata tggcatattg 300 aaaatgtcgc cgatgtgagt ttctgtgtaa ctgatatcgc catttttcca aaagtgattt 360 ttgggcatac gcgatatctg gcgatagcgc ttatatcgtt tacgggggat ggcgatagac 420 gactttggtg acttgggcga ttctgtgtgt cgcaaatatc gcagtttcga tataggtgac 480 agacgatatg aggctatatc gccgatagag gcgacatcaa gctggcacat ggccaatgca 540 tatcgatcta tacattgaat caatattggc cattagccat attattcatt ggttatatag 600 cataaatcaa tattggctat tggccattgc atacgttgta tccatatcat aatatgtaca 660 tttatattgg ctcatgtcca acattaccgc catgttgaca ttgattattg actagttatt 720 aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 780 aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 840 taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 900 agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 960 cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1020 tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1080 tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1140 gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1200 caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1260 aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac 1320 gctgttttga cctccataga agataccggg accgatccag cctccgcggc cgggaacggt 1380 gcattggaac gcggattccc cgtgccaaga gtgaccctgg cagaactcgg taagtctgtt 1440 gacatgtatg tgatgtatac taacctgcat gggacgtgga tttacttgtg tatgtcagat 1500 agagtaaaga ttaactcttg catgtgagcg gggcatcgag atagcgataa atgagtcagg 1560 aggacggagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca 1620 acgtgctggt tattgtgctg tctcatcatt ttggcaaaga atttcaccgt ccttgacacg 1680 aagtttgctc gagccacc 1698 <210> 780 <211> 2450 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 780 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga gcggggctga cgtcgggagg tggcctccgt 1020 gggaagggac acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata 1080 gattctggcc gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt 1140 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 1200 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgctcaggg 1260 ctgagcgcgg ggagagcaga gcacacaagc tcatagaccc tggtcgtggg ggggaggacc 1320 ggggagctgg cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc gccctcttcc 1380 cgagggtggg ggagaacggt atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa 1440 cgggtttgcc gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg 1500 gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat 1560 tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt 1620 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta 1680 ctccggccgc actctggtct tttttttttt gttgttgttg ccctgctgcc ttcgattgcc 1740 gttcagcaat aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga 1800 ggtcatggtt ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg 1860 agcacatgtc cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag 1920 gctggggtta gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg 1980 cgccgcgttg ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt 2040 gcgtggaaag atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2100 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc 2160 ggctgctgct tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg 2220 agcacggcta gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg 2280 gtgggtggag actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct 2340 tgagttttga gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc 2400 cttttttagg tgttgtgaaa accaccgcta attcaaagca agccgccacc 2450 <210> 781 <211> 2407 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 781 ccgcctagga catattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 60 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 120 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 180 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 240 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 300 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag 360 attgagatta acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct 420 gttggtattc attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag 480 tggcatttct tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt 540 gtatatatat atcagttact gttatggatc ccacgtcact attgtatact ctatattata 600 ctctatgtta tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta 660 agtctcccgt gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc 720 cggtatcgat tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag 780 cgcccctctt aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg 840 ggcatccgct actcccgagc tcgaattcgt ttatcggcca ccgaggccaa gatctggccg 900 ccatatactg agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag 960 gggtgaatca acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc 1020 attgggtttt gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta 1080 ttggcacgta cataaggtca ataggggtga gtcattgggt ttttccagcc aatttataaa 1140 acgccatgta ctttcccacc attgacgtca atgggctatt gaaactaatg caacgtgacc 1200 tttaaacggt actttcccat agctgattaa tgggaaagta ccgttctcga gccaatacac 1260 gtcaatggga agtgaaaggg cagccaaaac gtaacaccgc cccggttttc ccctggaaat 1320 tccatattgg cacgcattct attggctgag ctgcgttcta cgtgggtata agaggcgcga 1380 ccagcgtcgg tagggaccgg tttgccgcca gaacacaggt gaggggcggg tgtggcttcc 1440 gcgggccgcc gagctggagg tcctgctccg agcgggccgg gccccgctgt cgtcggcggg 1500 gattagctgc gagcattccc gcttcgagtt gcgggcggcg cgggaggcag agtgcgaggc 1560 ctagcggcaa ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcg 1620 ccgccgccgc gtgctactcc ggccgcactc tggtcttttt tttttttgtt gttgttgccc 1680 tgctgccttc gattgccgtt cagcaatagg ggctaacaaa gggagggtgc ggggcttgct 1740 cgcccggagc ccggagaggt catggttggg gaggaatgga gggacaggag tggcggctgg 1800 ggcccgcccg ccttcggagc acatgtccga cgccacctgg atggggcgag gcctggggtt 1860 tttcccgaag caaccaggct ggggttagcg tgccgaggcc atgtggcccc agcacccggc 1920 acgatctggc ttggcggcgc cgcgttgccc tgcctcccta actagggtga ggccatcccg 1980 tccggcacca gttgcgtgcg tggaaagatg gccgctcccg ggccctgttg caaggagctc 2040 aaaatggagg acgcggcagc ccggtggagc gggcgggtga gtcacccaca caaaggaaga 2100 gggcctggtc cctcaccggc tgctgcttcc tgtgaccccg tggtcctatc ggccgcaata 2160 gtcacctcgg gcttttgagc acggctagtc gcggcggggg gaggggatgt aatggcgttg 2220 gagtttgttc acatttggtg ggtggagact agtcaggcca gcctggcgct ggaagtcatt 2280 tttggaattt gtccccttga gttttgagcg gagctaattc tcgggcttct tagcggttca 2340 aaggtatctt ttaaaccctt ttttaggtgt tgtgaaaacc accgctaatt caaagcaagc 2400 cgccacc 2407 <210> 782 <211> 1820 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 782 ccgcctagga ctgtatactc tatattatac tctatgttat actctgtaat cctactcaat 60 aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg tcttcttatc accatcaggt 120 gacatcctcg cccaggctgt caatcatgcc ggtatcgatt ccagtagcac cggccccacg 180 ctgacaaccc actcttgcag cgttagcagc gcccctctta acaagccgac ccccaccagc 240 gtcgcggtta ctaacactcc tctccccggg gcatccgcta ctcccgagct cgaattcgtt 300 tatcggccac cgaggccaag atctggccgc catatactga gtcattaggg actttccaat 360 gggttttgcc cagtacataa ggtcaatagg ggtgaatcaa caggaaagtc ccattggagc 420 caagtacact gagtcaatag ggactttcca ttgggttttg cccagtacaa aaggtcaata 480 gggggtgagt caatgggttt ttcccattat tggcacgtac ataaggtcaa taggggtgag 540 tcattgggtt tttccagcca atttataaaa cgccatgtac tttcccacca ttgacgtcaa 600 tgggctattg aaactaatgc aacgtgacct ttaaacggta ctttcccata gctgattaat 660 gggaaagtac cgttctcgag ccaatacacg tcaatgggaa gtgaaagggc agccaaaacg 720 taacaccgcc ccggttttcc cctggaaatt ccatattggc acgcattcta ttggctgagc 780 tgcgttctac gtgggtataa gaggcgcgac cagcgtcggt agggaccggt ttgccgccag 840 aacacaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc ctgctctgag 900 cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat tcccacttcg 960 agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt agcctcgcct 1020 cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg gccgcactat 1080 gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa caaagggagg 1140 gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat ggaagggcag 1200 gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc tggatggggc 1260 gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg ccatgtggcc 1320 ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc aacaagggtg 1380 aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc ggggccctgt 1440 tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca 1500 cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc cgtggtctat 1560 cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg ggggagggga 1620 tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg ccagcctggc 1680 gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa ttctcaagcc 1740 tcttagcggt tcaaaggtat tttctaaacc cgtttccagg tgttgtgaaa accaccgcta 1800 attcaaagca agccgccacc 1820 <210> 783 <211> 2478 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 783 ccgcctagga catattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 60 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 120 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 180 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 240 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 300 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaagc atatactgag 360 attgagatta acttcctgtg aaacccagtg tcttagacaa ctgtggcttg agcaccacct 420 gttggtattc attacaaact tgctcactac aataaatgaa ttttaagctt taagatgaag 480 tggcatttct tttaacagtt actatgttgg aattggttac aaattttgga gtggactatt 540 gtatatatat atcagttact gttatggatc ccacgtcact attgtatact ctatattata 600 ctctatgtta tactctgtaa tcctactcaa taaacgtgtc acgcctgtga aaccgtacta 660 agtctcccgt gtcttgttat caccatcagg tgacatcctc gcccaggctg tcaatcatgc 720 cggtatcgat tccagtagca ccggccccac gctgacaacc cactcttgca gcgttagcag 780 cgcccctctt aacaagccga cccccaccag cgtcgcggtt actaacactc ctctccccgg 840 ggcatccgct actcccgagc tcgaattcgt ttatcggcca ccgaggccaa gatctggccg 900 ccaacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 960 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 1020 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc 1080 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 1140 cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccaagtc 1200 attgggtttt tccagccaat ttataaaacg ccatgtactt tcccaccatt gacgtcaatg 1260 ggctattgaa actaatgcaa cgtgaccttt aaacggtact ttcccatagc tgattaatgg 1320 gaaagtaccg ttctcgagcc aatacacgtc aatgggaagt gaaagggcag ccaaaacgta 1380 acaccgcccc ggttttcccc tggaaattcc atattggcac gcattctatt ggctgagctg 1440 cgttctacgt gggtataaga ggcgcgacca gcgtcggtag ggaccggttt gccgccagaa 1500 cacaggtgag tggcgggtgt ggcttccgcg ggccccggag ctggagccct gctctgagcg 1560 ggccgggctg atatgcgagt gtcgtccgca gggtttagct gtgagcattc ccacttcgag 1620 tggcgggcgg tgcgggggtg agagtgcgag gcctagcggc aaccccgtag cctcgcctcg 1680 tgtccggctt gaggcctagc gtggtgtccg ccgccgcgtg ccactccggc cgcactatgc 1740 gttttttgtc cttgctgccc tcgattgcct tccagcagca tgggctaaca aagggagggt 1800 gtggggctca ctcttaagga gcccatgaag cttacgttgg ataggaatgg aagggcagga 1860 ggggcgactg gggcccgccc gccttcggag cacatgtccg acgccacctg gatggggcga 1920 ggcctgtggc tttccgaagc aatcgggcgt gagtttagcc tacctgggcc atgtggccct 1980 agcactgggc acggtctggc ctggcggtgc cgcgttccct tgcctcccaa caagggtgag 2040 gccgtcccgc ccggcaccag ttgcttgcgc ggaaagatgg ccgctcccgg ggccctgttg 2100 caaggagctc aaaatggagg acgcggcagc ccggtggagc gggcgggtga gtcacccaca 2160 caaaggaaga gggccttgcc cctcgccggc cgctgcttcc tgtgaccccg tggtctatcg 2220 gccgcatagt cacctcgggc ttctcttgag caccgctcgt cgcggcgggg ggaggggatc 2280 taatggcgtt ggagtttgtt cacatttggt gggtggagac tagtcaggcc agcctggcgc 2340 tggaagtcat tcttggaatt tgcccctttg agtttggagc gaggctaatt ctcaagcctc 2400 ttagcggttc aaaggtattt tctaaacccg tttccaggtg ttgtgaaaac caccgctaat 2460 tcaaagcaag ccgccacc 2478 <210> 784 <211> 2394 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 784 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacattg attattgact agttattaat 840 agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac 900 ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa 960 tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt 1020 atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc 1080 ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat 1140 gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc 1200 ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc 1260 tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa 1320 aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg 1380 tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagaggc catccacgct 1440 gttttgacct ccatagtgga caccgggacc gatccagcct ccgcggccgg gaacggtgca 1500 ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga gtctataggc 1560 ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct atacaccccc 1620 gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt attgaccatt 1680 attgaccact cccctattgg tgacgatact ttccattact aatccataac atggctcttt 1740 gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac tgacacggac 1800 tctgtatttt tacaggatgg gttctcattt attatttaca aattcacata tacaacacca 1860 ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg cgaatctcgg 1920 gtacgtgttc cggacatggg ttcttctccg gtagcggcgg agcttctaca tccgagccct 1980 gctcccatgc ctccagcgac tcatggtcgc tcggcagctc cttgctccta acagtggagg 2040 ccagacttag gcacagcacg atgcccacca ccaccagtgt gccgcacaag gccgtggcgg 2100 tagggtatgt gtctgaaaat gagctcgggg agcgggcttg caccgctgac gcatttgaaa 2160 gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtgttc tgataagagt 2220 cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc tgagcagtac 2280 tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga ctgttccttt 2340 ccatgggtct tttctgcagt caccgtcctt gacacgaagt ttgctcgagc cacc 2394 <210> 785 <211> 2498 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 785 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga gcggggctga cgtcgggagg tggcctccgt 1020 gggaagggac acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata 1080 gattctggcc gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt 1140 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 1200 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgctcaggg 1260 ctgagcgcgg ggagagcaga gcacacaagc tcatagaccc tggtcgtggg ggggaggacc 1320 ggggagctgg cgcggggcaa actgggaaag cggtgtcgtg tgctggctcc gccctcttcc 1380 cgagggtggg ggagaacggt atataagtgc ggcagtcgcc ttggacgttc tttttcgcaa 1440 cgggtttgcc gtcagaacgc aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg 1500 gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat 1560 tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt 1620 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta 1680 ctccggccgc actctggtct tttttttttt gttgttgttg ccctgctgcc ttcgattgcc 1740 gttcagcaat aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga 1800 ggtcatggtt ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg 1860 agcacatgtc cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag 1920 gctggggtta gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg 1980 cgccgcgttg ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt 2040 gcgtggaaag atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2100 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc 2160 ggctgctgct tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg 2220 agcacggcta gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg 2280 gtgggtggag actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct 2340 tgagttttga gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc 2400 cttttttagg tgttgtgaaa accaccgcta attcaaagca aagcttgctt gttctttttg 2460 cagaagctca gaataaacgc tcaactttgg ccgccacc 2498 <210> 786 <211> 1906 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 786 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga cttacggtaa atggcccgcc tggctgaccg 1020 cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata 1080 gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta 1140 catcaagtgt atcatatgcc aagtccgccc cctattgacg tcaatgacgg taaatggccc 1200 gcctggcatt atgcccagta catgacctta cgggactttc ctacttggca gtacatctac 1260 gtattagtca tcgctattac catgctgatg cggttttggc agtacaccaa tgggcgtgga 1320 tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg 1380 ttttggcacc aaaatcaacg ggactttcca aaatgtcgta ataaccccgc cccgttgacg 1440 caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac 1500 cgtcagatcg cctggagacg ccatccacgc tgttttgacc tccatagaag ataccgggac 1560 cgatccagcc tccgcggccg ggaacggtgc attggaacgc ggattccccg tgccaagagt 1620 gaccctggca gaactcggta agtctgttga catgtatgtg atgtatacta acctgcatgg 1680 gacgtggatt tacttgtgta tgtcagatag agtaaagatt aactcttgca tgtgagcggg 1740 gcatcgagat agcgataaat gagtcaggag gacggagcct ctgctaacca tgttcatgcc 1800 ttcttctttt tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt 1860 ggcaaagaat ttcaccgtcc ttgacacgaa gtttgctcga gccacc 1906 <210> 787 <211> 1996 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 787 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc ggccgccatc tctggagacg 300 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 360 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 420 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 480 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 540 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaacccgcc 600 ccgaccggag ctgagagtaa ttcatacaaa aggactcgcc cctgccttgg ggaatcccag 660 ggaccgtcgt taaactccca ctaacgtaga acccagagat cgctgcgttc ccgccccctc 720 acccgcccgc tctcgtcatc actgaggtgg agaatagcat gcgtgaggct ccggtgcccg 780 tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa 840 ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg 900 gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa 960 cgttcttttt cgcaacgggt ttgccgccag aacacaggta agtgccgtgt gtggttcccg 1020 cgggcctggc ctctttacgg gttatggccc ttgcgtgcct tgaattactt ccacctggct 1080 ccagtacgtg attcttgatc ccgagctgga gccaggggcg ggccttgcgc tttaggagcc 1140 ccttcgcctc gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc 1200 tggtggcacc ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt 1260 tgatgacgtg ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaggat 1320 ctgcacactg gtatttcggt ttttgggccc gcggccggcg acggggcccg tgcgtcccag 1380 cgcacatgtt cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag 1440 tctcaagctg gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc 1500 tgggcggcaa ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc 1560 ggccctgctc cagggggctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag 1620 tcacccacac aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg 1680 gagtaccggg cgccgtccag gcacctcgat tagttctgga gcttttggag tacgtcgtct 1740 ttaggttggg gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact 1800 gaagttaggc cagcttggca cttgatgtaa ttctccttgg aatttggcct ttttgagttt 1860 ggatcttggt tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag 1920 gtgtcctgaa cacgtctcaa gcttgcttgt tctttttgca gaagctcaga ataaacgctc 1980 aactttggcc gccacc 1996 <210> 788 <211> 1411 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 788 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc ggccgccatc tctggagacg 300 acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat 360 aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga 420 gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 480 ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt 540 atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccaatgacgt 600 cgaggagaag ttccccaact ttcccgcctc tcagcctttg aaagaaagaa aggggagggg 660 gcaggccgcg tgcagccgcg agcggtgctg ggctccggct ccaattcccc atctcagtcg 720 ttcccaaagt cctcctgttt catccaagcg tgtaagggtc cccgtccttg actccctagt 780 gtcctgctgc ccacagtcca gtcctgggaa ccagcaccga tcacctccca tcgggccaat 840 ctcagtccct tcccccctac gtcggggccc acacgctcgg tgcgtgccca gttgaaccag 900 gcggctgcgg aaaaaaaaaa gcggggagaa agtagggccc ggctactagc ggttttacgg 960 gcgcacgtag ctcaggcctc aagaccttgg gctgggactg gctgagcctg gcgggaggcg 1020 gggtccgagt caccgcctgc cgccgcgccc ccggtttcta taaattgagc ccgcagcctc 1080 ccgcttcgct ctctgctcct cctgttcgac agtcagccgc atcttctttt gcgtcgccag 1140 cgtctcaggg gccctggcag aactcggtaa gtctgttgac atgtatgtga tgtatactaa 1200 cctgcatggg acgtggattt acttgtgtat gtcagataga gtaaagatta actcttgcat 1260 gtgagcgggg catcgagata gcgataaatg agtcaggagg acggatactt atatgtgttg 1320 ttatcctcct ctacagtcaa acagattaag gggtagcttg cttgttcttt ttgcagaagc 1380 tcagaataaa cgctcaactt tggccgccac c 1411 <210> 789 <211> 917 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 789 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc ggccgccata tactgagtca 300 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 360 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 420 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 480 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc 540 ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt 600 cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga 660 aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc 720 attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaccg 780 tcgcagtctt gggtctgacc accgtagaac gcagagctcc tcgctgcagt atcctgccca 840 agaaagagcg acccgtctca agcttgcttg ttctttttgc agaagctcag aataaacgct 900 caactttggc cgccacc 917 <210> 790 <211> 1797 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 790 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc ggccgccaag cggggctgac 300 gtcgggaggt ggcctccgtg ggaagggaca cccggatctt gacacagcct tggcagcgga 360 gtaaggaaga gtagggatag attctggccg ccctcttggc cagcttctcg ccgccccacc 420 ctccgctagg gccaagagta attcatacaa aaggagggat cgccttcgca aggggagagc 480 ccagggaccg tccctaaatt ctcacagacc caaatccctg tagccgcccc acgacagcgc 540 gaggagcatg cgctcagggc tgagcgcggg gagagcagag cacacaagct catagaccct 600 ggtcgtgggg gggaggaccg gggagctggc gcggggcaaa ctgggaaagc ggtgtcgtgt 660 gctggctccg ccctcttccc gagggtgggg gagaacggta tataagtgcg gcagtcgcct 720 tggacgttct ttttcgcaac gggtttgccg tcagaacgca ggtgaggggc gggtgtggct 780 tccgcgggcc gccgagctgg aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc 840 ggggattagc tgcgagcatt cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga 900 ggcctagcgg caaccccgta gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc 960 gcgccgccgc cgcgtgctac tccggccgca ctctggtctt tttttttttg ttgttgttgc 1020 cctgctgcct tcgattgccg ttcagcaata ggggctaaca aagggagggt gcggggcttg 1080 ctcgcccgga gcccggagag gtcatggttg gggaggaatg gagggacagg agtggcggct 1140 ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg aggcctgggg 1200 tttttcccga agcaaccagg ctggggttag cgtgccgagg ccatgtggcc ccagcacccg 1260 gcacgatctg gcttggcggc gccgcgttgc cctgcctccc taactagggt gaggccatcc 1320 cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc 1380 tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa 1440 gagggcctgg tccctcaccg gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa 1500 tagtcacctc gggcttttga gcacggctag tcgcggcggg gggaggggat gtaatggcgt 1560 tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg ctggaagtca 1620 tttttggaat ttgtcccctt gagttttgag cggagctaat tctcgggctt cttagcggtt 1680 caaaggtatc ttttaaaccc ttttttaggt gttgtgaaaa ccaccgctaa ttcaaagcaa 1740 agcttgcttg ttctttttgc agaagctcag aataaacgct caactttggc cgccacc 1797 <210> 791 <211> 2359 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 791 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 60 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 120 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 180 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 240 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 300 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 360 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 420 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 480 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 540 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 600 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 660 cagacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 720 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 780 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac 840 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 900 cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccaaccc 960 gccccgaccg gagctgagag taattcatac aaaaggactc gcccctgcct tggggaatcc 1020 cagggaccgt cgttaaactc ccactaacgt agaacccaga gatcgctgcg ttcccgcccc 1080 ctcacccgcc cgctctcgtc atcactgagg tggagaatag catgcgtgag gctccggtgc 1140 ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg gaggggtcgg 1200 caattgaacg ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta 1260 ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt 1320 gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc 1380 ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta cttccacctg 1440 gctccagtac gtgattcttg atcccgagct ggagccaggg gcgggccttg cgctttagga 1500 gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg ccgcgtgcga 1560 atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc catttaaaat 1620 ttttgatgac gtgctgcgac gctttttttc tggcaagata gtcttgtaaa tgcgggccag 1680 gatctgcaca ctggtatttc ggtttttggg cccgcggccg gcgacggggc ccgtgcgtcc 1740 cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat cggacggggg 1800 tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg tatcgccccg 1860 ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag atggccgctt 1920 cccggccctg ctccaggggg ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt 1980 gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc 2040 acggagtacc gggcgccgtc caggcacctc gattagttct ggagcttttg gagtacgtcg 2100 tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga gtgggtggag 2160 actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgg cctttttgag 2220 tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt tcttccattt 2280 caggtgtcct gaacacgtct caagcttgct tgttcttttt gcagaagctc agaataaacg 2340 ctcaactttg gccgccacc 2359 <210> 792 <211> 1774 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 792 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 60 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 120 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 180 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 240 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 300 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 360 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 420 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 480 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 540 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 600 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 660 cagacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc 720 aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt 780 ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac 840 gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac 900 cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccaatga 960 cgtcgaggag aagttcccca actttcccgc ctctcagcct ttgaaagaaa gaaaggggag 1020 ggggcaggcc gcgtgcagcc gcgagcggtg ctgggctccg gctccaattc cccatctcag 1080 tcgttcccaa agtcctcctg tttcatccaa gcgtgtaagg gtccccgtcc ttgactccct 1140 agtgtcctgc tgcccacagt ccagtcctgg gaaccagcac cgatcacctc ccatcgggcc 1200 aatctcagtc ccttcccccc tacgtcgggg cccacacgct cggtgcgtgc ccagttgaac 1260 caggcggctg cggaaaaaaa aaagcgggga gaaagtaggg cccggctact agcggtttta 1320 cgggcgcacg tagctcaggc ctcaagacct tgggctggga ctggctgagc ctggcgggag 1380 gcggggtccg agtcaccgcc tgccgccgcg cccccggttt ctataaattg agcccgcagc 1440 ctcccgcttc gctctctgct cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc 1500 cagcgtctca ggggccctgg cagaactcgg taagtctgtt gacatgtatg tgatgtatac 1560 taacctgcat gggacgtgga tttacttgtg tatgtcagat agagtaaaga ttaactcttg 1620 catgtgagcg gggcatcgag atagcgataa atgagtcagg aggacggata cttatatgtg 1680 ttgttatcct cctctacagt caaacagatt aaggggtagc ttgcttgttc tttttgcaga 1740 agctcagaat aaacgctcaa ctttggccgc cacc 1774 <210> 793 <211> 1300 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 793 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 60 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 120 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 180 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 240 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 300 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 360 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 420 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 480 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 540 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 600 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 660 cagggccgcc atatactgag tcattaggga ctttccaatg ggttttgccc agtacataag 720 gtcaataggg gtgaatcaac aggaaagtcc cattggagcc aagtacactg agtcaatagg 780 gactttccat tgggttttgc ccagtacaaa aggtcaatag ggggtgagtc aatgggtttt 840 tcccattatt ggcacgtaca taaggtcaat aggggtgagt cattgggttt ttccagccaa 900 tttataaaac gccatgtact ttcccaccat tgacgtcaat gggctattga aactaatgca 960 acgtgacctt taaacggtac tttcccatag ctgattaatg ggaaagtacc gttctcgagc 1020 caatacacgt caatgggaag tgaaagggca gccaaaacgt aacaccgccc cggttttccc 1080 ctggaaattc catattggca cgcattctat tggctgagct gcgttctacg tgggtataag 1140 aggcgcgacc agcgtcggta ccgtcgcagt cttgggtctg accaccgtag aacgcagagc 1200 tcctcgctgc agtatcctgc ccaagaaaga gcgacccgtc tcaagcttgc ttgttctttt 1260 tgcagaagct cagaataaac gctcaacttt ggccgccacc 1300 <210> 794 <211> 2172 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 794 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 60 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 120 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 180 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 240 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 300 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 360 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 420 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 480 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 540 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 600 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 660 cagagcgggg ctgacgtcgg gaggtggcct ccgtgggaag ggacacccgg atcttgacac 720 agccttggca gcggagtaag gaagagtagg gatagattct ggccgccctc ttggccagct 780 tctcgccgcc ccaccctccg ctagggccaa gagtaattca tacaaaagga gggatcgcct 840 tcgcaagggg agagcccagg gaccgtccct aaattctcac agacccaaat ccctgtagcc 900 gccccacgac agcgcgagga gcatgcgctc agggctgagc gcggggagag cagagcacac 960 aagctcatag accctggtcg tgggggggag gaccggggag ctggcgcggg gcaaactggg 1020 aaagcggtgt cgtgtgctgg ctccgccctc ttcccgaggg tgggggagaa cggtatataa 1080 gtgcggcagt cgccttggac gttctttttc gcaacgggtt tgccgtcaga acgcaggtga 1140 ggggcgggtg tggcttccgc gggccgccga gctggaggtc ctgctccgag cgggccgggc 1200 cccgctgtcg tcggcgggga ttagctgcga gcattcccgc ttcgagttgc gggcggcgcg 1260 ggaggcagag tgcgaggcct agcggcaacc ccgtagcctc gcctcgtgtc cggcttgagg 1320 cctagcgtgg tgtccgcgcc gccgccgcgt gctactccgg ccgcactctg gtcttttttt 1380 ttttgttgtt gttgccctgc tgccttcgat tgccgttcag caataggggc taacaaaggg 1440 agggtgcggg gcttgctcgc ccggagcccg gagaggtcat ggttggggag gaatggaggg 1500 acaggagtgg cggctggggc ccgcccgcct tcggagcaca tgtccgacgc cacctggatg 1560 gggcgaggcc tggggttttt cccgaagcaa ccaggctggg gttagcgtgc cgaggccatg 1620 tggccccagc acccggcacg atctggcttg gcggcgccgc gttgccctgc ctccctaact 1680 agggtgaggc catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc gctcccgggc 1740 cctgttgcaa ggagctcaaa atggaggacg cggcagcccg gtggagcggg cgggtgagtc 1800 acccacacaa aggaagaggg cctggtccct caccggctgc tgcttcctgt gaccccgtgg 1860 tcctatcggc cgcaatagtc acctcgggct tttgagcacg gctagtcgcg gcggggggag 1920 gggatgtaat ggcgttggag tttgttcaca tttggtgggt ggagactagt caggccagcc 1980 tggcgctgga agtcattttt ggaatttgtc cccttgagtt ttgagcggag ctaattctcg 2040 ggcttcttag cggttcaaag gtatctttta aacccttttt taggtgttgt gaaaaccacc 2100 gctaattcaa agcaaagctt gcttgttctt tttgcagaag ctcagaataa acgctcaact 2160 ttggccgcca cc 2172 <210> 795 <211> 3976 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 795 gggtaatcga gtacgatagc cggctaatca gccataccac atttgtagag gttttacttg 60 ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg 120 ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt 180 tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg 240 tatcttatca tgtctggaat tcggacggtg actgggcctt tcgcccgggc taattatggg 300 gtgtcgccct tcgctgaagg ccctccgcgc ctacagctca agccacatcc gaagggggag 360 ggagccggga gctgcgcgcg gggccgccgg ggggaggggt ggcaccgccc acgccgggcg 420 gccacgaagg gcggggcagc gggcgcgcgc ccggcggggg gaggggccgc gcgccgcgcc 480 cgctgggaat tggggcccta gggggagggc ggaggcgccg acgaccgcgg cacttaccgt 540 tcgcggcgtg gcgcccggtg gtccccaagg ggagggaagg gggaggcggg gcgaggacag 600 tgaccggagt ctcctcagcg gtggcttttc tgcttggcag cctcagcggc tggcgccaaa 660 accggactcc gcccacttcc tcgcccctgc ggtgcgaggg tgtggaatcc tccagacgct 720 gggggagggg gagttgggag cttaaaaact agtacccctt tgggaccact ttcagcagcg 780 aactctcctg tacaccaggg gtcagttcca cagacgcggg ccaggggtgg gtcattgcgg 840 cgtgaacaat aatttgacta gaagttgatt cgggtgtttc cggaaggggc cgagtcaatc 900 cgccgagttg gggcacggaa aacaaaaagg gaaggctact aagatttttc tggcgggggt 960 tatcattggc gtaactgcag ggaccacctc ccgggttgag ggggctggat ctccaggctg 1020 cggattaagc ccctcccgtc ggcgttaatt tcaaactgcg cgaccgtttc tcacctgcct 1080 tgcgccaagg cagggggcgg gaccctattc caagaggtag taactagcag gactctagcc 1140 ttccgcaatt cattgagcgc atttacggaa gtaacgtcgg gtactgtctc tggccgcaag 1200 ggtgggagga gtacgcattt ggcgtaaggt ggggcgtaga gccttcccgc cattggcggc 1260 ggatagggcg tttacgcgac ggcctgacgt agcggatgac gcgttagtgg gggggaaggt 1320 tctagaaaag cggcggcagc ggctctagcg gcagtagcag cagcgccggg tcccgtgcgg 1380 aggtgctcct cgcagagttg tttctcgagc agcggcagtt ctcactacag cgccaggacg 1440 agtccggttc gtgttcgtcc gcggagatcg atctctctca tctcgctcgg ctgcgggaaa 1500 tcgggctgaa gcgactgagt ccgcgatgga ggtaacgggt ttgaaatcaa tgagttattg 1560 aaaagggcat ggcgaggccg ttggcgcctc agtggaagtc ggccagccgc ctccgtggga 1620 gagaggcagg aaatcggacc aattcagtag cagtggggct taaggtttat gaacggggtc 1680 ttgagcggag gcctgagcgt acaaacagct tccccaccct cagcctcccg gcgccatttc 1740 ccttcactgg gggtggggga tggggagctt tcacatggcg gacgctgccc cgctggggtg 1800 aaagtggggc gcggaggcgg gaattcttat tccctttcta aagcacgctg cttcgggggc 1860 cacggcgact cctcggcgtc cgaaatacgc gttttgagat ttctgtcgcc gactaaattc 1920 atgtcgcgcg atagtggtgt ttatcgccga tagagatggc gatattggaa aaatcgatat 1980 ttgaaaatat ggcatattga aaatgtcgcc gatgtgagtt tctgtgtaac tgatatcgcc 2040 atttttccaa aagtgatttt tgggcatacg cgatatctgg cgatagcgct tatatcgttt 2100 acgggggatg gcgatagacg actttggtga cttgggcgat tctgtgtgtc gcaaatatcg 2160 cagtttcgat ataggtgaca gacgatatga ggctatatcg ccgatagagg cgacatcaag 2220 ctggcacatg gccaatgcat atcgatctat acattgaatc aatattggcc attagccata 2280 ttattcattg gttatatagc ataaatcaat attggctatt ggccattgca tacgttgtat 2340 ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc atgttgacat 2400 tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat 2460 atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac 2520 ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc 2580 cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg 2640 tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat 2700 tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc 2760 atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt 2820 gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac 2880 caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc 2940 ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc 3000 gcctggagag gccatccacg ctgttttgac ctccatagtg gacaccggga ccgatccagc 3060 ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag tgacgtaagt 3120 accgcctata gagtctatag gcccaccccc ttggcttctt atgcatgcta tactgttttt 3180 ggcttggggt ctatacaccc ccgcttcctc atgttatagg tgatggtata gcttagccta 3240 taggtgtggg ttattgacca ttattgacca ctcccctatt ggtgacgata ctttccatta 3300 ctaatccata acatggctct ttgccacaac tctctttatt ggctatatgc caatacactg 3360 tccttcagag actgacacgg actctgtatt tttacaggat gggttctcat ttattattta 3420 caaattcaca tatacaacac caccgtcccc agtgcccgca gtttttatta aacataacgt 3480 gggatctcca cgcgaatctc gggtacgtgt tccggacatg ggttcttctc cggtagcggc 3540 ggagcttcta catccgagcc ctgctcccat gcctccagcg actcatggtc gctcggcagc 3600 tccttgctcc taacagtgga ggccagactt aggcacagca cgatgcccac caccaccagt 3660 gtgccgcaca aggccgtggc ggtagggtat gtgtctgaaa atgagctcgg ggagcgggct 3720 tgcaccgctg acgcatttga aagacttaag gcagcggcag aagaagatgc aggcagctga 3780 gttgttgtgt tctgataaga gtcagaggta actcccgttg cggtgctgtt aacggtggag 3840 ggcagtgtag tctgagcagt actcgttgct gccgcgcgcg ccaccagaca taatagctga 3900 cagactaaca gactgttcct ttccatgggt cttttctgca gtcaccgtcc ttgacacgaa 3960 gtttgctcga gccacc 3976 <210> 796 <211> 2562 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 796 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcagctggac 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt atacatcgtt 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatctgt atactctata ttatactcta tgttatactc tgtaatccta 780 ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct cccgtgtctt cttatcacca 840 tcaggtgaca tcctcgccca ggctgtcaat catgccggta tcgattccag tagcaccggc 900 cccacgctga caacccactc ttgcagcgtt agcagcgccc ctcttaacaa gccgaccccc 960 accagcgtcg cggttactaa cactcctctc cccggggcat ccgctactcc cgagctcgaa 1020 ttcgtttatc ggccaccgag gccaagatct ggccgccata tactgagtca ttagggactt 1080 tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg aaagtcccat 1140 tggagccaag tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg 1200 tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg 1260 ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc ccaccattga 1320 cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt cccatagctg 1380 attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga aagggcagcc 1440 aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc attctattgg 1500 ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaggg accggtttgc 1560 cgccagaaca caggtgaggg gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg 1620 ctccgagcgg gccgggcccc gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc 1680 gagttgcggg cggcgcggga ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc 1740 tcgtgtccgg cttgaggcct agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg 1800 cactctggtc tttttttttt ttgttgttgt tgccctgctg ccttcgattg ccgttcagca 1860 ataggggcta acaaagggag ggtgcggggc ttgctcgccc ggagcccgga gaggtcatgg 1920 ttggggagga atggagggac aggagtggcg gctggggccc gcccgccttc ggagcacatg 1980 tccgacgcca cctggatggg gcgaggcctg gggtttttcc cgaagcaacc aggctggggt 2040 tagcgtgccg aggccatgtg gccccagcac ccggcacgat ctggcttggc ggcgccgcgt 2100 tgccctgcct ccctaactag ggtgaggcca tcccgtccgg caccagttgc gtgcgtggaa 2160 agatggccgc tcccgggccc tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt 2220 ggagcgggcg ggtgagtcac ccacacaaag gaagagggcc tggtccctca ccggctgctg 2280 cttcctgtga ccccgtggtc ctatcggccg caatagtcac ctcgggcttt tgagcacggc 2340 tagtcgcggc ggggggaggg gatgtaatgg cgttggagtt tgttcacatt tggtgggtgg 2400 agactagtca ggccagcctg gcgctggaag tcatttttgg aatttgtccc cttgagtttt 2460 gagcggagct aattctcggg cttcttagcg gttcaaaggt atcttttaaa ccctttttta 2520 ggtgttgtga aaaccaccgc taattcaaag caagccgcca cc 2562 <210> 797 <211> 3220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 797 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcagctggac 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt atacatcgtt 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcata ttatccctaa tacttgccac cccactctta atcagtggtg 780 gaagaacggt gtcagaactg tttgtttcaa ttggccattt aagtttagta gtaaaagact 840 ggttaatgat aacaatgcat cgtaaaacct tcagaaggaa aggagaatgt tttgtggacc 900 actttggttt tcttttttgc gtgtggcagt tttaagttat tagtttttaa aatcagtact 960 ttttaatgga aacaacttga ccaaaaattt gtcacagaat tttgagatcc attaaaaaag 1020 ttaaatgaga aacctgtgtg ttcctttggt caacaccgag acatttaggt gaaagcatat 1080 actgagattg agattaactt cctgtgaaac ccagtgtctt agacaactgt ggcttgagca 1140 ccacctgttg gtattcatta caaacttgct cactacaata aatgaatttt aagctttaag 1200 atgaagtggc atttctttta acagttacta tgttggaatt ggttacaaat tttggagtgg 1260 actattgtat atatatatca gttactgtta tggatcccac gtcactattg tatactctat 1320 attatactct atgttatact ctgtaatcct actcaataaa cgtgtcacgc ctgtgaaacc 1380 gtactaagtc tcccgtgtct tgttatcacc atcaggtgac atcctcgccc aggctgtcaa 1440 tcatgccggt atcgattcca gtagcaccgg ccccacgctg acaacccact cttgcagcgt 1500 tagcagcgcc cctcttaaca agccgacccc caccagcgtc gcggttacta acactcctct 1560 ccccggggca tccgctactc ccgagctcga attcgtttat cggccaccga ggccaagatc 1620 tggccgccaa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt 1680 gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca 1740 atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc 1800 aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta 1860 catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac 1920 caagtcattg ggtttttcca gccaatttat aaaacgccat gtactttccc accattgacg 1980 tcaatgggct attgaaacta atgcaacgtg acctttaaac ggtactttcc catagctgat 2040 taatgggaaa gtaccgttct cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa 2100 aacgtaacac cgccccggtt ttcccctgga aattccatat tggcacgcat tctattggct 2160 gagctgcgtt ctacgtgggt ataagaggcg cgaccagcgt cggtagggac cggtttgccg 2220 ccagaacaca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg aggtcctgct 2280 ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt cccgcttcga 2340 gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta gcctcgcctc 2400 gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac tccggccgca 2460 ctctggtctt tttttttttt gttgttgttg ccctgctgcc ttcgattgcc gttcagcaat 2520 aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga ggtcatggtt 2580 ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg agcacatgtc 2640 cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag gctggggtta 2700 gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg cgccgcgttg 2760 ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt gcgtggaaag 2820 atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc agcccggtgg 2880 agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc ggctgctgct 2940 tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg agcacggcta 3000 gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg gtgggtggag 3060 actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct tgagttttga 3120 gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc cttttttagg 3180 tgttgtgaaa accaccgcta attcaaagca agccgccacc 3220 <210> 798 <211> 1469 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 798 ccgcctagga ctgtatactc tatattatac tctatgttat actctgtaat cctactcaat 60 aaacgtgtca cgcctgtgaa accgtactaa gtctcccgtg tcttcttatc accatcaggt 120 gacatcctcg cccaggctgt caatcatgcc ggtatcgatt ccagtagcac cggccccacg 180 ctgacaaccc actcttgcag cgttagcagc gcccctctta acaagccgac ccccaccagc 240 gtcgcggtta ctaacactcc tctccccggg gcatccgcta ctcccgagct cgaattcgtt 300 tatcggccac cgaggccaag atctggccgc caattgatta ttgactagtt attaatagta 360 atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac 420 ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac 480 gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt 540 acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc cgccccctat 600 tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttacggga 660 ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt 720 ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca 780 ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg 840 tcgtaataac cccgccccgt tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta 900 tataagcaga gctcgtttag tgaaccgtca gatcctcact ctcttccgca tcgctgtctg 960 cgagggccag ctgttgggct cgcggttgag gacaaactct tcgcggtctt tccagtactc 1020 ttggatcgga aacccgtcgg cctccgaacg gtactccgcc accgagggac ctgagcgagt 1080 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 1140 gtaggctgag caccgtggcg ggcggcagcg ggtggcggtc ggggttgttt ctggcggagg 1200 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gaggtgaggt 1260 gtggcaggct tgagatccag ctgttggggt gagtactccc tctcaaaagc gggcattact 1320 tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt tgatattcac ctggcccgat 1380 ctggccatac acttgagtga caatgacatc cactttgcct ttctctccac aggtgtccac 1440 tcccaggtcc aagtttaaac gccgccacc 1469 <210> 799 <211> 1824 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 799 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatctat tcggacggtg acgatatttg aaaatatggc 420 atattgaaaa tgtcgccgat gtgagtttct gtgtaactga tatcgccatt tttccaaaag 480 tgatttttgg gcatacgcga tatctggcga tagcgcttat atcgtttacg ggggatggcg 540 atagacgact ttggtgactt gggcgattct gtgtgtcgca aatatcgcag tttcgatata 600 ggtgacagac gatatgaggc tatatcgccg atagaggcga catcaagctg gcacatggcc 660 aatgcatatc gatctataca ttgaatcaat attggccatt agccatatta ttcattggtt 720 atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcca tatcataata 780 tgtacattta tattggctca tgtccaacat taccgccatg ttgacattga ttattgacta 840 gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg 900 ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga 960 cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat 1020 gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa 1080 gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca 1140 tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca 1200 tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat 1260 ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg 1320 actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac 1380 ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc 1440 atccacgctg ttttgacctc catagaagat accgggaccg atccagcctc cgcggccggg 1500 aacggtgcat tggaacgcgg attccccgtg ccaagagtga ccctggcaga actcggtaag 1560 tctgttgaca tgtatgtgat gtatactaac ctgcatggga cgtggattta cttgtgtatg 1620 tcagatagag taaagattaa ctcttgcatg tgagcggggc atcgagatag cgataaatga 1680 gtcaggagga cggagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc 1740 tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattt caccgtcctt 1800 gacacgaagt ttgctgccgc cacc 1824 <210> 800 <211> 2229 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 800 atattacccc taacacctgc caccccagtc ttaatcagtg gtggaagaac tctcagaact 60 gtttgtctca attggccatt taagtttaat agtgaaagac tggttaatga taacaatgca 120 tcggaaaacc ttcaggagga aaggagaatg ttttgtggaa catttttgtg tgtgtggcag 180 ttttaagtta ttagttttca aaatcagtac tttttaatgg aaacaacttg accaaaaatc 240 tgtcacagaa ttttgaaccc attaaaatac aagtttaatg agaagtctgt ctctgttaat 300 gctgaagtca ttactaagtg cttagcttag caaggtatgt ggatgcccat ttgtgttcca 360 agggattgga ctgttcatca ggacccagag ctgtgtatac tctatattat actctatgtt 420 atactctgta atcctactca ataaacgtgt cacgcctgtg aaaccgtact aagtctcccg 480 tgtcttctta tcaccatcag gtgacatcct cgcccaggct gtcaatcatg ccggtatcga 540 ttccagtagc accggcccca cgctgacaac ccactcttgc agcgttagca gcgcccctct 600 taacaagccg acccccacca gcgtcgcggt tactaacact cctctccccg gggcatccgc 660 tactcccgag ctcgttaaat gagaaacctg tgtgttcctt tggggcgggg ctgacgtcgg 720 gaggtggcct ccacgggaag ggacacccgg atctcgacac agccttggca gtggagtcag 780 gaagggtagg acagattctg gacgccctct tggccagtcc tcaccgcccc acccccgatg 840 gagccgagag taattcatac aaaaggaggg atcgccttcg cccctgggaa tcccagggac 900 cgtcgctaaa ttctggccgg cctcccagcc cggaaccgct gtgcccgccc agcgcggcgg 960 gaggagcctg cgcctagggc ggatcgcggg tcggcgggag agcacaagcc cacagtcccc 1020 ggcggtgggg gaggggcgcg ctgagcgggg gcccgggagc cagcgcgggg caaactggga 1080 aagtggtgtc gtgtgctggc tccgccctct tcccgagggt gggggagaac ggtataaaag 1140 tgcggtagtc gcgttggacg ttctttttcg caacgggttt gccgtcagaa cgcaggtgag 1200 tggcgggtgt ggcctccgcg ggcccgggct ccctcctttg agcggggtcg gaccgccgtg 1260 cgggtgtcgt cggccgggct tctctgcgag cgttcccgcc ctggatggcg ggctgtgcgg 1320 gagggcgagg gggggaggcc tggcggcggc cccggagcct cgcctcgtgt cgggcgtgag 1380 gcctagcgtg gcttccgccc cgccgcgtgc caccgcggcc gcgctttgct gtctgcccgg 1440 ctgccctcga ttgcctgccc gcggcccggg ccaacaaagg gagggcgtgg agctggctgg 1500 tagggagccc cgtagtccgc atgtcgggca gggagagcgg cagcagtcgg gggggggacc 1560 gggcccgccc gtcccgcagc acatgtccga cgccgcctgg acgggtagcg gcctgtgtcc 1620 tgataaggcg gccgggcggt gggttttaga tgccgggttc aggtggcccc gggtcccggc 1680 ccggtctggc cagtaccccg tagtggctta gctccgagga gggcgagccc gcccgcccgg 1740 caccagttgc gtgcgcggaa agatggccgc tcccgggccc tgtagcaagg agctcaaaat 1800 ggaggacgcg gcagcccggc ggagcggggc gggtgagtca cccacacaaa ggaagagggc 1860 cttgcccctc gccggccgct gcttcctgtg accccgtggt gtaccggccg cacttcagtc 1920 accccgggcg ctctttcgga gcaccgctgg cctccgctgg gggaggggat ctgtctaatg 1980 gcgttggagt ttgctcacat ttggtgggtg gagactgtag ccaggccagc ctggccatgg 2040 aagtaattct tggaatttgc ccattttgag tttggagcga agctgattga caaagctgct 2100 tagccgttca aaggtattct tcgaactttt tttttaaggt gttgtgaaaa ccaccgctaa 2160 ttcaaatcca acagcttgct tgttcttttt gcagaagctc agaataaacg ctcaactttg 2220 gccgccacc 2229 <210> 801 <211> 1824 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 801 ccacagacct ggtgaccgtc aggaagaaga ttcagtgaga ggacacgagg tatgtcatgg 60 tttttaatca ataaataaag aggttttatt catcggacag tcgttgtagc ctgtaaaaga 120 ctcgccccgg agggggttcc cccgatgtga ggggcatgca gtagtatggt gtcctgagtg 180 tctcggatgc gtccttgaac tcgcactcta ccgccgtggg ggttaataaa gttttgctgc 240 gccggtaggg ggggaggccg aggataataa agttgctacg tactggttga agtctaacaa 300 tctctcgggg ggatcccctc tcccggccag aggagcaagg tatgcgggag gcgaccagga 360 ggatagcggg gctgacgtcg ggaggtggcc tccgtgggaa ggacacccgg atcttgacac 420 agccttggca gcggagtcag gaagagtagg ggtaggttct ggacgccctc ttggccagct 480 catcgccgcc ccaccctctg ctggagcaca gagtaattca tacaaaagga gggatcgcct 540 tcgcaagggg agagcccagg gaccgtccct aaattctcac agacccaaat ccctgtagcc 600 gccccacgac agcgcgagga gcatgcgccc agggctgagc gcgggtagat cagagcacac 660 aagctcacag tccccggcgg tggggggagg ggcgcgctga gcgggggcca gggagctggc 720 gcggggcaaa ctgggaaagt ggtgtcgtgt gctggctccg ccctcttccc gagggtgggg 780 gagaacggta tataagtgcg gtagtcgcct tggacgttct ttttcgcaac gggtttgccg 840 tcagaacgca ggtgagtggc gggtgtggct tccgcgggcc ccggagctgg agccctgctc 900 tgagcgggcc gggctgatat gcgagtgtcg tccgcagggt ttagctgtga gcattcccac 960 ttcgagtggc gggcggtgcg ggggtgagag tgcgaggcct agcggcaacc ccgtagcctc 1020 gcctcgtgtc cggcttgagg cctagcgtgg tgtccgccgc cgcgtgccac tccggccgca 1080 ctatgcgttt tttgtccttg ctgccctcga ttgccttcca gcagcatggg ctaacaaagg 1140 gagggtgtgg ggctcactct taaggagccc atgaagctta cgttggatag gaatggaagg 1200 gcaggagggg cgactggggc ccgcccgcct tcggagcaca tgtccgacgc cacctggatg 1260 gggcgaggcc tgtggctttc cgaagcaatc gggcgtgagt ttagcctacc tgggccatgt 1320 ggccctagca ctgggcacgg tctggcctgg cggtgccgcg ttcccttgcc tcccaacaag 1380 ggtgaggccg tcccgcccgg caccagttgc ttgcgcggaa agatggccgc tcccggggcc 1440 ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg tggagcgggc gggtgagtca 1500 cccacacaaa ggaagagggc cttgcccctc gccggccgct gcttcctgtg accccgtggt 1560 ctatcggccg catagtcacc tcgggcttct cttgagcacc gctcgtcgcg gcggggggag 1620 gggatctaat ggcgttggag tttgttcaca tttggtgggt ggagactagt caggccagcc 1680 tggcgctgga agtcattctt ggaatttgcc cctttgagtt tggagcgagg ctaattctca 1740 agcctcttag cggttcaaag gtattttcta aacccgtttc caggtgttgt gaaagccacc 1800 gctaattcaa agcaagccgc cacc 1824 <210> 802 <211> 2344 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 802 atattacccc taacacctgc caccccagtc ttaatcagtg gtggaagaac tctcagaact 60 gtttgtctca attggccatt taagtttaat agtgaaagac tggttaatga taacaatgca 120 tcggaaaacc ttcaggagga aaggagaatg ttttgtggaa catttttgtg tgtgtggcag 180 ttttaagtta ttagttttca aaatcagtac tttttaatgg aaacaacttg accaaaaatc 240 tgtcacagaa ttttgaaccc attaaaatac aagtttaatg agaagtctgt ctctgttaat 300 gctgaagtca ttactaagtg cttagcttag caaggtatgt ggatgcccat ttgtgttcca 360 agggattgga ctgttcatca ggacccagag ctgatccaca agcccagctc cccacccatc 420 accatggaca atgttttttt actaacactt ggacaatgat ggatactttt ttactaacac 480 ttggacaatg atgatgatac actcctcact tgcccactta gacacaatta ctaacaccac 540 accccctctt ttatttctct gtacttaatg ttttctgaat aaagtgatcc tattgtaccc 600 acattaaaga cttctttaac tctttatggt tcacaggacc cgagatgaac atagatattg 660 ttacagcagc ggcctccatg tcaggtataa ctactgcctc acacagcgcc ctgccaatca 720 gaaggttaaa tgagaaacct gtgtgttcct ttggggccgc catatactga gtcattaggg 780 actttccaat gggttttgcc cagtacataa ggtcaatagg ggtgaatcaa caggaaagtc 840 ccattggagc caagtacact gagtcaatag ggactttcca ttgggttttg cccagtacaa 900 aaggtcaata gggggtgagt caatgggttt ttcccattat tggcacgtac ataaggtcaa 960 taggggtgag tcattgggtt tttccagcca atttataaaa cgccatgtac tttcccacca 1020 ttgacgtcaa tgggctattg aaactaatgc aacgtgacct ttaaacggta ctttcccata 1080 gctgattaat gggaaagtac cgttctcgag ccaatacacg tcaatgggaa gtgaaagggc 1140 agccaaaacg taacaccgcc ccggttttcc cctggaaatt ccatattggc acgcattcta 1200 ttggctgagc tgcgttctac gtgggtataa gaggcgcgac cagcgtcggt agggaccggt 1260 ttgccgccag aacacagctt tttcgcaacg ggtttgccgt cagaacgcag gtgagtggcg 1320 ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg ggtcggaccg ccgtgcgggt 1380 gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga tggcgggctg tgcgggaggg 1440 cgaggggggg aggcctggcg gcggccccgg agcctcgcct cgtgtcgggc gtgaggccta 1500 gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct ttgctgtctg cccggctgcc 1560 ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg cgtggagctg gctggtaggg 1620 agccccgtag tccgcatgtc gggcagggag agcggcagca gtcggggggg ggaccgggcc 1680 cgcccgtccc gcagcacatg tccgacgccg cctggacggg tagcggcctg tgtcctgata 1740 aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg gccccgggtc ccggcccggt 1800 ctggccagta ccccgtagtg gcttagctcc gaggagggcg agcccgcccg cccggcacca 1860 gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag caaggagctc aaaatggagg 1920 acgcggcagc ccggcggagc ggggcgggtg agtcacccac acaaaggaag agggccttgc 1980 ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc ggccgcactt cagtcacccc 2040 gggcgctctt tcggagcacc gctggcctcc gctgggggag gggatctgtc taatggcgtt 2100 ggagtttgct cacatttggt gggtggagac tgtagccagg ccagcctggc catggaagta 2160 attcttggaa tttgcccatt ttgagtttgg agcgaagctg attgacaaag ctgcttagcc 2220 gttcaaaggt attcttcgaa cttttttttt aaggtgttgt gaaaaccacc gctaattcaa 2280 atccaacagc ttgcttgttc tttttgcaga agctcagaat aaacgctcaa ctttggccgc 2340 cacc 2344 <210> 803 <211> 1088 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 803 atccacaagc ccagctcccc acccatcacc atggacaatg tttttttact aacacttgga 60 caatgatgga tactttttta ctaacacttg gacaatgatg atgatacact cctcacttgc 120 ccacttagac acaattacta acaccacacc ccctctttta tttctctgta cttaatgttt 180 tctgaataaa gtgatcctat tgtacccaca ttaaagactt ctttaactct ttatggttca 240 caggacccga gatgaacata gatattgtta cagcagcggc ctccatgtca ggtataacta 300 ctgcctcaca cagcgccctg ccaatcagaa ggatctggcc gccatatact gagtcattag 360 ggactttcca atgggttttg cccagtacat aaggtcaata ggggtgaatc aacaggaaag 420 tcccattgga gccaagtaca ctgagtcaat agggactttc cattgggttt tgcccagtac 480 aaaaggtcaa tagggggtga gtcaatgggt ttttcccatt attggcacgt acataaggtc 540 aataggggtg agtcattggg tttttccagc caatttataa aacgccatgt actttcccac 600 cattgacgtc aatgggctat tgaaactaat gcaacgtgac ctttaaacgg tactttccca 660 tagctgatta atgggaaagt accgttctcg agccaataca cgtcaatggg aagtgaaagg 720 gcagccaaaa cgtaacaccg ccccggtttt cccctggaaa ttccatattg gcacgcattc 780 tattggctga gctgcgttct acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc 840 agtcttgggt ctgaccaccg tagaacgcag agctcctcgc tgtcagatcg cctggagacg 900 ccccgtgtct acccatcaga caagtaagtt tctgtttcca tttcctctct tgtgacacat 960 ttcatgactc tgcatttaca taacccctga ctcatggtct tcccactctt gttctctcag 1020 ggtgccagct cagcttgctt gttctttttg cagaagctca gaataaacgc tcaactttgg 1080 ccgccacc 1088 <210> 804 <211> 1073 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 804 ccacagacct ggtgaccgtc aggaagaaga ttcagtgaga ggacacgagg tatgtcatgg 60 tttttaatca ataaataaag aggttttatt catcggacag tcgttgtagc ctgtaaaaga 120 ctcgccccgg agggggttcc cccgatgtga ggggcatgca gtagtatggt gtcctgagtg 180 tctcggatgc gtccttgaac tcgcactcta ccgccgtggg ggttaataaa gttttgctgc 240 gccggtaggg ggggaggccg aggataataa agttgctacg tactggttga agtctaacaa 300 tctctcgggg ggatccgatc tggccgccat atactgagtc attagggact ttccaatggg 360 ttttgcccag tacataaggt caataggggt gaatcaacag gaaagtccca ttggagccaa 420 gtacactgag tcaataggga ctttccattg ggttttgccc agtacaaaag gtcaataggg 480 ggtgagtcaa tgggtttttc ccattattgg cacgtacata aggtcaatag gggtgagtca 540 ttgggttttt ccagccaatt tataaaacgc catgtacttt cccaccattg acgtcaatgg 600 gctattgaaa ctaatgcaac gtgaccttta aacggtactt tcccatagct gattaatggg 660 aaagtaccgt tctcgagcca atacacgtca atgggaagtg aaagggcagc caaaacgtaa 720 caccgccccg gttttcccct ggaaattcca tattggcacg cattctattg gctgagctgc 780 gttctacgtg ggtataagag gcgcgaccag cgtcggtacc gtcgcagtct tgggtctgac 840 caccgtagaa cgcagagctc ctcgctgtca gatcgcctgg agacgccccg tgtctaccca 900 tcagacaagt aagtttctgt ttccatttcc tctcttgtga cacatttcat gactctgcat 960 ttacataacc cctgactcat ggtcttccca ctcttgttct ctcagggtgc cagctcagct 1020 tgcttgttct ttttgcagaa gctcagaata aacgctcaac tttggccgcc acc 1073 <210> 805 <211> 1222 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 805 ccgcctagga cccacagacc tggtgaccgt caggaagaag attcagtgag aggacacgag 60 gtatgtcatg gtttttaatc aataaataaa gaggttttat tcatcggaca gtcgttgtag 120 cctgtaaaag actcgccccg gagggggttc ccccgatgtg aggggcatgc agtagtatgg 180 tgtcctgagt gtctcggatg cgtccttgaa ctcgcactct accgccgtgg gggttaataa 240 agttttgctg cgccggtagg gggggaggcc gaggataata aagttgctac gtactggttg 300 aagtctaaca atctctcggg gggatccgaa ttcgtttatc ggccaccgag gccaagatct 360 ggccgccaat tgattattga ctagttatta atagtaatca attacggggt cattagttca 420 tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc 480 gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat 540 agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt 600 acatcaagtg tatcatatgc caagtccgcc ccctattgac gtcaatgacg gtaaatggcc 660 cgcctggcat tatgcccagt acatgacctt acgggacttt cctacttggc agtacatcta 720 cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacacca atgggcgtgg 780 atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt 840 gttttggcac caaaatcaac gggactttcc aaaatgtcgt aataaccccg ccccgttgac 900 gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa 960 ccgtcagatc tcgcagtctt gggtctgacc accgtagaac gcagagctcc tcgctgtcag 1020 atcgcctgga gacgccccgt gtctacccat cagacaagta agtttctgtt tccatttcct 1080 ctcttgtgac acatttcatg actctgcatt tacataaccc ctgactcatg gtcttcccac 1140 tcttgttctc tcagggtgcc agctcagctt gcttgttctt tttgcagaag ctcagaataa 1200 acgctcaact ttggccgcca cc 1222 <210> 806 <211> 1692 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 806 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatctat tcggacggtg acgatatttg aaaatatggc 420 atattgaaaa tgtcgccgat gtgagtttct gtgtaactga tatcgccatt tttccaaaag 480 tgatttttgg gcatacgcga tatctggcga tagcgcttat atcgtttacg ggggatggcg 540 atagacgact ttggtgactt gggcgattct gtgtgtcgca aatatcgcag tttcgatata 600 ggtgacagac gatatgaggc tatatcgccg atagaggcga catcaagctg gcacatggcc 660 aatgcatatc gatctataca ttgaatcaat attggccatt agccatatta ttcattggtt 720 atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcca tatcataata 780 tgtacattta tattggctca tgtccaacat taccgccatg ttgacgatct ggccgccata 840 tactgagtca ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg 900 aatcaacagg aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg 960 gttttgccca gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc 1020 acgtacataa ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc 1080 atgtactttc ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa 1140 acggtacttt cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa 1200 tgggaagtga aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat 1260 attggcacgc attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc 1320 gtcggtaccg tcgcagtctt gggtctgacc accgtagaac gcagagctcc tcgctgattg 1380 gaacgcggat tccccgtgcc aagagtgacc ctggcagaac tcggtaagtc tgttgacatg 1440 tatgtgatgt atactaacct gcatgggacg tggatttact tgtgtatgtc agatagagta 1500 aagattaact cttgcatgtg agcggggcat cgagatagcg ataaatgagt caggaggacg 1560 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1620 tggttattgt gctgtctcat cattttggca aagaatttca ccgtccttga cacgaagttt 1680 gctgccgcca cc 1692 <210> 807 <211> 1373 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 807 tgtatactct atattatact ctatgttata ctctgtaatc ctactcaata aacgtgtcac 60 gcctgtgaaa ccgtactaag tctcccgtgt cttcttatca ccatcaggtg acatcctcgc 120 ccaggctgtc aatcatgccg gtatcgattc cagtagcacc ggccccacgc tgacaaccca 180 ctcttgcagc gttagcagcg cccctcttaa caagccgacc cccaccagcg tcgcggttac 240 taacactcct ctccccgggg catccgctac tcccgagctc gatctggccg ccatatactg 300 agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 360 acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 420 gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacgta 480 cataaggtca ataggggtga gtcattgggt ttttccagcc aatttataaa acgccatgta 540 ctttcccacc attgacgtca atgggctatt gaaactaatg caacgtgacc tttaaacggt 600 actttcccat agctgattaa tgggaaagta ccgttctcga gccaatacac gtcaatggga 660 agtgaaaggg cagccaaaac gtaacaccgc cccggttttc ccctggaaat tccatattgg 720 cacgcattct attggctgag ctgcgttcta cgtgggtata agaggcgcga ccagcgtcgg 780 taccgtcgca gtcttgggtc tgaccaccgt agaacgcaga gctcctcgct gtcagatcct 840 cactctcttc cgcatcgctg tctgcgaggg ccagctgttg ggctcgcggt tgaggacaaa 900 ctcttcgcgg tctttccagt actcttggat cggaaacccg tcggcctccg aacggtactc 960 cgccaccgag ggacctgagc gagtccgcat cgaccggatc ggaaaacctc tcgagaaagg 1020 cgtctaacca gtcacagtcg caaggtaggc tgagcaccgt ggcgggcggc agcgggtggc 1080 ggtcggggtt gtttctggcg gaggtgctgc tgatgatgta attaaagtag gcggtcttga 1140 gacggcggat ggtcgaggtg aggtgtggca ggcttgagat ccagctgttg gggtgagtac 1200 tccctctcaa aagcgggcat tacttctgcg ctaagattgt cagtttccaa aaacgaggag 1260 gatttgatat tcacctggcc cgatctggcc atacacttga gtgacaatga catccacttt 1320 gcctttctct ccacaggtgt ccactcccag gtccaagttt aaacgccgcc acc 1373 <210> 808 <211> 1785 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 808 atctgtatac tctatattat actctatgtt atactctgta atcctactca ataaacgtgt 60 cacgcctgtg aaaccgtact aagtctcccg tgtattctta tcaccatcag gtgacatcct 120 cgcccaggct gtcaatcatg ccggtatcga ttccagtagc accggcccca cgctgacaac 180 ccactcttgc agcgttagca gcgcccctct taacaagccg acccccacca gcgtcgcggt 240 tactaacact cctctccccg gggcatccgc tactcccgag ctcgaattcg tttatcggcc 300 accgaggcca agatctggcc gccaagcggg gctgacgtcg ggaggtggcc tccgtgggaa 360 gggacacccg gatcttgaca cagccttggc agcggagtaa ggaagagtag ggatagattc 420 tggccgccct cttggccagc ttctcgccgc cccaccctcc gctagggcca agagtaattc 480 atacaaaagg agggatcgcc ttcgcaaggg gagagcccag ggaccgtccc taaattctca 540 cagacccaaa tccctgtagc cgccccacga cagcgcgagg agcatgcgct cagggctgag 600 cgcggggaga gcagagcaca caagctcata gaccctggtc gtggggggga ggaccgggga 660 gctggcgcgg ggcaaactgg gaaagcggtg tcgtgtgctg gctccgccct cttcccgagg 720 gtgggggaga acggtatata agtgcggcag tcgccttgga cgttcttttt cgcaacgggt 780 ttgccgtcag aacgcaggtg aggggcgggt gtggcttccg cgggccgccg agctggaggt 840 cctgctccga gcgggccggg ccccgctgtc gtcggcgggg attagctgcg agcattcccg 900 cttcgagttg cgggcggcgc gggaggcaga gtgcgaggcc tagcggcaac cccgtagcct 960 cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgcgc cgccgccgcg tgctactccg 1020 gccgcactct ggtctttttt tttttgttgt tgttgccctg ctgccttcga ttgccgttca 1080 gcaatagggg ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc ggagaggtca 1140 tggttgggga ggaatggagg gacaggagtg gcggctgggg cccgcccgcc ttcggagcac 1200 atgtccgacg ccacctggat ggggcgaggc ctggggtttt tcccgaagca accaggctgg 1260 ggttagcgtg ccgaggccat gtggccccag cacccggcac gatctggctt ggcggcgccg 1320 cgttgccctg cctccctaac tagggtgagg ccatcccgtc cggcaccagt tgcgtgcgtg 1380 gaaagatggc cgctcccggg ccctgttgca aggagctcaa aatggaggac gcggcagccc 1440 ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gcctggtccc tcaccggctg 1500 ctgcttcctg tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc ttttgagcac 1560 ggctagtcgc ggcgggggga ggggatgtaa tggcgttgga gtttgttcac atttggtggg 1620 tggagactag tcaggccagc ctggcgctgg aagtcatttt tggaatttgt ccccttgagt 1680 tttgagcgga gctaattctc gggcttctta gcggttcaaa ggtatctttt aaaccctttt 1740 ttaggtgttg tgaaaaccac cgctaattca aagcaagccg ccacc 1785 <210> 809 <211> 1725 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 809 atctgtatac tctatattat actctatgtt atactctgta atcctactca ataaacgtgt 60 cacgcctgtg aaaccgtact aagtctcccg tgtattctta tcaccatcag gtgacatcct 120 cgcccaggct gtcaatcatg ccggtatcga ttccagtagc accggcccca cgctgacaac 180 ccactcttgc agcgttagca gcgcccctct taacaagccg acccccacca gcgtcgcggt 240 tactaacact cctctccccg gggcatccgc tactcccgag ctcgaattcg tttatcggcc 300 accgaggcca agatctggcc gccaacccgc cccgaccgga gctgagagta attcatacaa 360 aaggactcgc ccctgccttg gggaatccca gggaccgtcg ttaaactccc actaacgtag 420 aacccagaga tcgctgcgtt cccgccccct cacccgcccg ctctcgtcat cactgaggtg 480 gagaatagca tgcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag 540 tccccgagaa gttgggggga ggggtcggca attgaacggg tgcctagaga aggtggcgcg 600 gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag 660 aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca 720 gaacacaggt aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc 780 cttgcgtgcc ttgaattact tccacctggc tccagtacgt gattcttgat cccgagctgg 840 agccaggggc gggccttgcg ctttaggagc cccttcgcct cgtgcttgag ttgaggcctg 900 gcctgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct gtctcgctgc 960 tttcgataag tctctagcca tttaaaattt ttgatgacgt gctgcgacgc tttttttctg 1020 gcaagatagt cttgtaaatg cgggccagga tctgcacact ggtatttcgg tttttgggcc 1080 cgcggccggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc ggggcctgcg 1140 agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg ctctggtgcc 1200 tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc ggtcggcacc 1260 agttgcgtga gcggaaagat ggccgcttcc cggccctgct ccagggggct caaaatggag 1320 gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaaa gggcctttcc 1380 gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca ggcacctcga 1440 ttagttctgg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt tttatgcgat 1500 ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc acttgatgta 1560 attctccttg gaatttggcc tttttgagtt tggatcttgg ttcattctca agcctcagac 1620 agtggttcaa agtttttttc ttccatttca ggtgtcgtga aaactaccag cttgcttgtt 1680 ctttttgcag aagctcagaa taaacgctca actttggccg ccacc 1725 <210> 810 <211> 2451 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 810 atcataacag gcctattgat tggaaagttt gtcaacgaat tgtgggtctt ttggggtttg 60 ctgccccttt tacgcaatgt ggatatcctg ctttaatgcc tttatatgca tgtatacaag 120 caaaacaggc ttttactttc tcgccaactt acaaggcctt tctcagtaaa cagtatatga 180 ccctttaccc cgttgctcgg caacggcctg gtctgtgcca agtgtttgct gacgcaaccc 240 ccactggttg gggcttggcc ataggccatc agcgcatgcg tggaaccttt gtgtctcctc 300 tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcacctgg agtggagcaa 360 acctcatcgg gaccgacaat tctgtcgtac tctcccgcaa gtcatcatcg tttccttggc 420 tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac gtcccgtcgg 480 cgctgaatcc cgcggacgac ccctcccggg gccgcttggg gctctaccgc ccgcttctcc 540 gtctgccgta ccgtccgacc acggggcgca cctctcttta cgcggactcc ccgtctgtgc 600 cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca tggaggccac 660 cgtgaacgcc caccggaact tgcccaaggt cttgcataag aggactcttg gactttcagc 720 aatgtcatct gtatactcta tattatactc tatgttatac tctgtaatcc tactcaataa 780 acgtgtcacg cctgtgaaac cgtactaagt ctcccgtgta ttcttatcac catcaggtga 840 catcctcgcc caggctgtca atcatgccgg tatcgattcc agtagcaccg gccccacgct 900 gacaacccac tcttgcagcg ttagcagcgc ccctcttaac aagccgaccc ccaccagcgt 960 cgcggttact aacactcctc tccccggggc atccgctact cccgagctcg aattcgttta 1020 tcggccaccg aggccaagat ctggccgcca acccgccccg accggagctg agagtaattc 1080 atacaaaagg actcgcccct gccttgggga atcccaggga ccgtcgttaa actcccacta 1140 acgtagaacc cagagatcgc tgcgttcccg ccccctcacc cgcccgctct cgtcatcact 1200 gaggtggaga atagcatgcg tgaggctccg gtgcccgtca gtgggcagag cgcacatcgc 1260 ccacagtccc cgagaagttg gggggagggg tcggcaattg aacgggtgcc tagagaaggt 1320 ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg 1380 ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg 1440 ccgccagaac acaggtaagt gccgtgtgtg gttcccgcgg gcctggcctc tttacgggtt 1500 atggcccttg cgtgccttga attacttcca cctggctcca gtacgtgatt cttgatcccg 1560 agctggagcc aggggcgggc cttgcgcttt aggagcccct tcgcctcgtg cttgagttga 1620 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 1680 cgctgctttc gataagtctc tagccattta aaatttttga tgacgtgctg cgacgctttt 1740 tttctggcaa gatagtcttg taaatgcggg ccaggatctg cacactggta tttcggtttt 1800 tgggcccgcg gccggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1860 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1920 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1980 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctccag ggggctcaaa 2040 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 2100 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 2160 cctcgattag ttctggagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 2220 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 2280 gatgtaattc tccttggaat ttggcctttt tgagtttgga tcttggttca ttctcaagcc 2340 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgaaaac taccagcttg 2400 cttgttcttt ttgcagaagc tcagaataaa cgctcaactt tggccgccac c 2451 <210> 811 <211> 1425 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 811 cttgctcacc tcgagtacga tagccggcta atcagccaat ccacaagccc agctccccac 60 ccatcaccat ggacaatgtt tttttactaa cacttggaca atgatggata cttttttact 120 aacacttgga caatgatgat gatacactcc tcacttgccc acttagacac aattactaac 180 accacacccc ctcttttatt tctctgtact taatgttttc tgaataaagt gatcctattg 240 tacccacatt aaagacttct ttaactcttt atggttcaca ggacccgaga tgaacataga 300 tattgttaca gcagcggcct ccatgtcagg tataactact gcctcacaca gcgccctgcc 360 aatcagaagc atatcataat atgtacattt atattggctc atgtccaaca ttaccgccat 420 gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata 480 gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc 540 ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag 600 ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac 660 atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg 720 cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg 780 tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat 840 agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt 900 tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc 960 aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc 1020 gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga taccgggacc 1080 gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt gccaagagtg 1140 accctggcag aactcggtaa gtctgttgac atgtatgtga tgtatactaa cctgcatggg 1200 acgtggattt acttgtgtat gtcagataga gtaaagatta actcttgcat gtgagcgggg 1260 catcgagata gcgataaatg agtcaggagg acggagcctc tgctaaccat gttcatgcct 1320 tcttcttttt cctacagctc ctgggcaacg tgctggttat tgtgctgtct catcattttg 1380 gcaaagaatt tcaccgtcct tgacacgaag tttgctgccg ccacc 1425 <210> 812 <211> 3133 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 812 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcata ttatccctaa tacttgccac cccactctta atcagtggtg 780 gaagaacggt gtcagaactg tttgtttcaa ttggccattt aagtttagta gtaaaagact 840 ggttaatgat aacaatgcat cgtaaaacct tcagaaggaa aggagaatgt tttgtggacc 900 actttggttt tcttttttgc gtgtggcagt tttaagttat tagtttttaa aatcagtact 960 ttttaatgga aacaacttga ccaaaaattt gtcacagaat tttgagatcc attaaaaaag 1020 ttaaatgaga aacctgtgtg ttcctttggt caacaccgag acatttaggt gaaagcatat 1080 actgagattg agattaactt cctgtgaaac ccagtgtctt agacaactgt ggcttgagca 1140 ccacctgttg gtattcatta caaacttgct cactacaata aatgaatttt aagctttaag 1200 atgaagtggc atttctttta acagttacta tgttggaatt ggttacaaat tttggagtgg 1260 actattgtat atatatatca gttactgtta tggatcccac gtcactattg tatactctat 1320 attatactct atgttatact ctgtaatcct actcaataaa cgtgtcacgc ctgtgaaacc 1380 gtactaagtc tcccgtgtct tgttatcacc atcaggtgac atcctcgccc aggctgtcaa 1440 tcatgccggt atcgattcca gtagcaccgg ccccacgctg acaacccact cttgcagcgt 1500 tagcagcgcc cctcttaaca agccgacccc caccagcgtc gcggttacta acactcctct 1560 ccccggggca tccgctactc ccgagctcga attcgtttat cggccaccga ggccaagatc 1620 tggccgccat atactgagtc attagggact ttccaatggg ttttgcccag tacataaggt 1680 caataggggt gaatcaacag gaaagtccca ttggagccaa gtacactgag tcaataggga 1740 ctttccattg ggttttgccc agtacaaaag gtcaataggg ggtgagtcaa tgggtttttc 1800 ccattattgg cacgtacata aggtcaatag gggtgagtca ttgggttttt ccagccaatt 1860 tataaaacgc catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac 1920 gtgaccttta aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca 1980 atacacgtca atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttcccct 2040 ggaaattcca tattggcacg cattctattg gctgagctgc gttctacgtg ggtataagag 2100 gcgcgaccag cgtcggtagg gaccggtttg ccgccagaac acaggtgagg ggcgggtgtg 2160 gcttccgcgg gccgccgagc tggaggtcct gctccgagcg ggccgggccc cgctgtcgtc 2220 ggcggggatt agctgcgagc attcccgctt cgagttgcgg gcggcgcggg aggcagagtg 2280 cgaggcctag cggcaacccc gtagcctcgc ctcgtgtccg gcttgaggcc tagcgtggtg 2340 tccgcgccgc cgccgcgtgc tactccggcc gcactctggt cttttttttt tttgttgttg 2400 ttgccctgct gccttcgatt gccgttcagc aataggggct aacaaaggga gggtgcgggg 2460 cttgctcgcc cggagcccgg agaggtcatg gttggggagg aatggaggga caggagtggc 2520 ggctggggcc cgcccgcctt cggagcacat gtccgacgcc acctggatgg ggcgaggcct 2580 ggggtttttc ccgaagcaac caggctgggg ttagcgtgcc gaggccatgt ggccccagca 2640 cccggcacga tctggcttgg cggcgccgcg ttgccctgcc tccctaacta gggtgaggcc 2700 atcccgtccg gcaccagttg cgtgcgtgga aagatggccg ctcccgggcc ctgttgcaag 2760 gagctcaaaa tggaggacgc ggcagcccgg tggagcgggc gggtgagtca cccacacaaa 2820 ggaagagggc ctggtccctc accggctgct gcttcctgtg accccgtggt cctatcggcc 2880 gcaatagtca cctcgggctt ttgagcacgg ctagtcgcgg cggggggagg ggatgtaatg 2940 gcgttggagt ttgttcacat ttggtgggtg gagactagtc aggccagcct ggcgctggaa 3000 gtcatttttg gaatttgtcc ccttgagttt tgagcggagc taattctcgg gcttcttagc 3060 ggttcaaagg tatcttttaa accctttttt aggtgttgtg aaaaccaccg ctaattcaaa 3120 gcaagccgcc acc 3133 <210> 813 <211> 3070 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 813 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cacctggagt ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagtc atcatcgttt ccttggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcatat tacccctaac acctgccacc ccagtcttaa tcagtggtgg aagaactctc 780 agaactgttt gtctcaattg gccatttaag tttaatagtg aaagactggt taatgataac 840 aatgcatcgg aaaaccttca ggaggaaagg agaatgtttt gtggaacatt tttgtgtgtg 900 tggcagtttt aagttattag ttttcaaaat cagtactttt taatggaaac aacttgacca 960 aaaatctgtc acagaatttt gaacccatta aaatacaagt ttaatgagaa gtctgtctct 1020 gttaatgctg aagtcattac taagtgctta gcttagcaag gtatgtggat gcccatttgt 1080 gttccaaggg attggactgt tcatcaggac ccagagctga tccacaagcc cagctcccca 1140 cccatcacca tggacaatgt ttttttacta acacttggac aatgatggat acttttttac 1200 taacacttgg acaatgatga tgatacactc ctcacttgcc cacttagaca caattactaa 1260 caccacaccc cctcttttat ttctctgtac ttaatgtttt ctgaataaag tgatcctatt 1320 gtacccacat taaagacttc tttaactctt tatggttcac aggacccgag atgaacatag 1380 atattgttac agcagcggcc tccatgtcag gtataactac tgcctcacac agcgccctgc 1440 caatcagaag gttaaatgag aaacctgtgt gttcctttgg ggccgccata tactgagtca 1500 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 1560 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 1620 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 1680 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc 1740 ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt 1800 cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga 1860 aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc 1920 attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaggg 1980 accggtttgc cgccagaaca cagctttttc gcaacgggtt tgccgtcaga acgcaggtga 2040 gtggcgggtg tggcctccgc gggcccgggc tccctccttt gagcggggtc ggaccgccgt 2100 gcgggtgtcg tcggccgggc ttctctgcga gcgttcccgc cctggatggc gggctgtgcg 2160 ggagggcgag ggggggaggc ctggcggcgg ccccggagcc tcgcctcgtg tcgggcgtga 2220 ggcctagcgt ggcttccgcc ccgccgcgtg ccaccgcggc cgcgctttgc tgtctgcccg 2280 gctgccctcg attgcctgcc cgcggcccgg gccaacaaag ggagggcgtg gagctggctg 2340 gtagggagcc ccgtagtccg catgtcgggc agggagagcg gcagcagtcg ggggggggac 2400 cgggcccgcc cgtcccgcag cacatgtccg acgccgcctg gacgggtagc ggcctgtgtc 2460 ctgataaggc ggccgggcgg tgggttttag atgccgggtt caggtggccc cgggtcccgg 2520 cccggtctgg ccagtacccc gtagtggctt agctccgagg agggcgagcc cgcccgcccg 2580 gcaccagttg cgtgcgcgga aagatggccg ctcccgggcc ctgtagcaag gagctcaaaa 2640 tggaggacgc ggcagcccgg cggagcgggg cgggtgagtc acccacacaa aggaagaggg 2700 ccttgcccct cgccggccgc tgcttcctgt gaccccgtgg tgtaccggcc gcacttcagt 2760 caccccgggc gctctttcgg agcaccgctg gcctccgctg ggggagggga tctgtctaat 2820 ggcgttggag tttgctcaca tttggtgggt ggagactgta gccaggccag cctggccatg 2880 gaagtaattc ttggaatttg cccattttga gtttggagcg aagctgattg acaaagctgc 2940 ttagccgttc aaaggtattc ttcgaacttt ttttttaagg tgttgtgaaa accaccgcta 3000 attcaaatcc aacagcttgc ttgttctttt tgcagaagct cagaataaac gctcaacttt 3060 ggccgccacc 3070 <210> 814 <211> 2546 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 814 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatctgt atactctata ttatactcta tgttatactc tgtaatccta 780 ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct cccgtgtctt cttatcacca 840 tcaggtgaca tcctcgccca ggctgtcaat catgccggta tcgattccag tagcaccggc 900 cccacgctga caacccactc ttgcagcgtt agcagcgccc ctcttaacaa gccgaccccc 960 accagcgtcg cggttactaa cactcctctc cccggggcat ccgctactcc cgagctcgaa 1020 ttcgtttatc ggccaccgag gccaagatct ggccgccata tactgagtca ttagggactt 1080 tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg aaagtcccat 1140 tggagccaag tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg 1200 tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg 1260 ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc ccaccattga 1320 cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt cccatagctg 1380 attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga aagggcagcc 1440 aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc attctattgg 1500 ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaggg accggtttgc 1560 cgccagaaca caggtgagtg gcgggtgtgg cttccgcggg ccccggagct ggagccctgc 1620 tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg gtttagctgt gagcattccc 1680 acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc ctagcggcaa ccccgtagcc 1740 tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc gccgcgtgcc actccggccg 1800 cactatgcgt tttttgtcct tgctgccctc gattgccttc cagcagcatg ggctaacaaa 1860 gggagggtgt ggggctcact cttaaggagc ccatgaagct tacgttggat aggaatggaa 1920 gggcaggagg ggcgactggg gcccgcccgc cttcggagca catgtccgac gccacctgga 1980 tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga gtttagccta cctgggccat 2040 gtggccctag cactgggcac ggtctggcct ggcggtgccg cgttcccttg cctcccaaca 2100 agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg aaagatggcc gctcccgggg 2160 ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg gcgggtgagt 2220 cacccacaca aaggaagagg gccttgcccc tcgccggccg ctgcttcctg tgaccccgtg 2280 gtctatcggc cgcatagtca cctcgggctt ctcttgagca ccgctcgtcg cggcgggggg 2340 aggggatcta atggcgttgg agtttgttca catttggtgg gtggagacta gtcaggccag 2400 cctggcgctg gaagtcattc ttggaatttg cccctttgag tttggagcga ggctaattct 2460 caagcctctt agcggttcaa aggtattttc taaacccgtt tccaggtgtt gtgaaaacca 2520 ccgctaattc aaagcaagcc gccacc 2546 <210> 815 <211> 3175 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 815 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cacctggagt ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagtc atcatcgttt ccttggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcatat tatccctaat acttgccacc ccactcttaa tcagtggtgg aagaacggtg 780 tcagaactgt ttgtttcaat tggccattta agtttagtag taaaagactg gttaatgata 840 acaatgcatc gtaaaacctt cagaaggaaa ggagaatgtt ttgtggacca ctttggtttt 900 cttttttgcg tgtggcagtt ttaagttatt agtttttaaa atcagtactt tttaatggaa 960 acaacttgac caaaaatttg tcacagaatt ttgagatcca ttaaaaaagt taaatgagaa 1020 acctgtgtgt tcctttggtc aacaccgaga catttaggtg aaagcatata ctgagattga 1080 gattaacttc ctgtgaaacc cagtgtctta gacaactgtg gcttgagcac cacctgttgg 1140 tattcattac aaacttgctc actacaataa atgaatttta agctttaaga tgaagtggca 1200 tttcttttaa cagttactat gttggaattg gttacaaatt ttggagtgga ctattgtata 1260 tatatatcag ttactgttat ggatcccacg tcactattgt atactctata ttatactcta 1320 tgttatactc tgtaatccta ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct 1380 cccgtgtctt gttatcacca tcaggtgaca tcctcgccca ggctgtcaat catgccggta 1440 tcgattccag tagcaccggc cccacgctga caacccactc ttgcagcgtt agcagcgccc 1500 ctcttaacaa gccgaccccc accagcgtcg cggttactaa cactcctctc cccggggcat 1560 ccgctactcc cgagctctcc tttggggccg ccatatactg agtcattagg gactttccaa 1620 tgggttttgc ccagtacata aggtcaatag gggtgaatca acaggaaagt cccattggag 1680 ccaagtacac tgagtcaata gggactttcc attgggtttt gcccagtaca aaaggtcaat 1740 agggggtgag tcaatgggtt tttcccatta ttggcacgta cataaggtca ataggggtga 1800 gtcattgggt ttttccagcc aatttataaa acgccatgta ctttcccacc attgacgtca 1860 atgggctatt gaaactaatg caacgtgacc tttaaacggt actttcccat agctgattaa 1920 tgggaaagta ccgttctcga gccaatacac gtcaatggga agtgaaaggg cagccaaaac 1980 gtaacaccgc cccggttttc ccctggaaat tccatattgg cacgcattct attggctgag 2040 ctgcgttcta cgtgggtata agaggcgcga ccagcgtcgg tagggaccgg tttgccgcca 2100 gaacacagct ttttcgcaac gggtttgccg tcagaacgca ggtgagtggc gggtgtggcc 2160 tccgcgggcc cgggctccct cctttgagcg gggtcggacc gccgtgcggg tgtcgtcggc 2220 cgggcttctc tgcgagcgtt cccgccctgg atggcgggct gtgcgggagg gcgagggggg 2280 gaggcctggc ggcggccccg gagcctcgcc tcgtgtcggg cgtgaggcct agcgtggctt 2340 ccgccccgcc gcgtgccacc gcggccgcgc tttgctgtct gcccggctgc cctcgattgc 2400 ctgcccgcgg cccgggccaa caaagggagg gcgtggagct ggctggtagg gagccccgta 2460 gtccgcatgt cgggcaggga gagcggcagc agtcgggggg gggaccgggc ccgcccgtcc 2520 cgcagcacat gtccgacgcc gcctggacgg gtagcggcct gtgtcctgat aaggcggccg 2580 ggcggtgggt tttagatgcc gggttcaggt ggccccgggt cccggcccgg tctggccagt 2640 accccgtagt ggcttagctc cgaggagggc gagcccgccc gcccggcacc agttgcgtgc 2700 gcggaaagat ggccgctccc gggccctgta gcaaggagct caaaatggag gacgcggcag 2760 cccggcggag cggggcgggt gagtcaccca cacaaaggaa gagggccttg cccctcgccg 2820 gccgctgctt cctgtgaccc cgtggtgtac cggccgcact tcagtcaccc cgggcgctct 2880 ttcggagcac cgctggcctc cgctggggga ggggatctgt ctaatggcgt tggagtttgc 2940 tcacatttgg tgggtggaga ctgtagccag gccagcctgg ccatggaagt aattcttgga 3000 atttgcccat tttgagtttg gagcgaagct gattgacaaa gctgcttagc cgttcaaagg 3060 tattcttcga actttttttt taaggtgttg tgaaaaccac cgctaattca aatccaacag 3120 cttgcttgtt ctttttgcag aagctcagaa taaacgctca actttggccg ccacc 3175 <210> 816 <211> 3117 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 816 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcata ttatccctaa tacttgccac cccactctta atcagtggtg 780 gaagaacggt gtcagaactg tttgtttcaa ttggccattt aagtttagta gtaaaagact 840 ggttaatgat aacaatgcat cgtaaaacct tcagaaggaa aggagaatgt tttgtggacc 900 actttggttt tcttttttgc gtgtggcagt tttaagttat tagtttttaa aatcagtact 960 ttttaatgga aacaacttga ccaaaaattt gtcacagaat tttgagatcc attaaaaaag 1020 ttaaatgaga aacctgtgtg ttcctttggt caacaccgag acatttaggt gaaagcatat 1080 actgagattg agattaactt cctgtgaaac ccagtgtctt agacaactgt ggcttgagca 1140 ccacctgttg gtattcatta caaacttgct cactacaata aatgaatttt aagctttaag 1200 atgaagtggc atttctttta acagttacta tgttggaatt ggttacaaat tttggagtgg 1260 actattgtat atatatatca gttactgtta tggatcccac gtcactattg tatactctat 1320 attatactct atgttatact ctgtaatcct actcaataaa cgtgtcacgc ctgtgaaacc 1380 gtactaagtc tcccgtgtct tgttatcacc atcaggtgac atcctcgccc aggctgtcaa 1440 tcatgccggt atcgattcca gtagcaccgg ccccacgctg acaacccact cttgcagcgt 1500 tagcagcgcc cctcttaaca agccgacccc caccagcgtc gcggttacta acactcctct 1560 ccccggggca tccgctactc ccgagctcga attcgtttat cggccaccga ggccaagatc 1620 tggccgccat atactgagtc attagggact ttccaatggg ttttgcccag tacataaggt 1680 caataggggt gaatcaacag gaaagtccca ttggagccaa gtacactgag tcaataggga 1740 ctttccattg ggttttgccc agtacaaaag gtcaataggg ggtgagtcaa tgggtttttc 1800 ccattattgg cacgtacata aggtcaatag gggtgagtca ttgggttttt ccagccaatt 1860 tataaaacgc catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac 1920 gtgaccttta aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca 1980 atacacgtca atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttcccct 2040 ggaaattcca tattggcacg cattctattg gctgagctgc gttctacgtg ggtataagag 2100 gcgcgaccag cgtcggtagg gaccggtttg ccgccagaac acaggtgagt ggcgggtgtg 2160 gcttccgcgg gccccggagc tggagccctg ctctgagcgg gccgggctga tatgcgagtg 2220 tcgtccgcag ggtttagctg tgagcattcc cacttcgagt ggcgggcggt gcgggggtga 2280 gagtgcgagg cctagcggca accccgtagc ctcgcctcgt gtccggcttg aggcctagcg 2340 tggtgtccgc cgccgcgtgc cactccggcc gcactatgcg ttttttgtcc ttgctgccct 2400 cgattgcctt ccagcagcat gggctaacaa agggagggtg tggggctcac tcttaaggag 2460 cccatgaagc ttacgttgga taggaatgga agggcaggag gggcgactgg ggcccgcccg 2520 ccttcggagc acatgtccga cgccacctgg atggggcgag gcctgtggct ttccgaagca 2580 atcgggcgtg agtttagcct acctgggcca tgtggcccta gcactgggca cggtctggcc 2640 tggcggtgcc gcgttccctt gcctcccaac aagggtgagg ccgtcccgcc cggcaccagt 2700 tgcttgcgcg gaaagatggc cgctcccggg gccctgttgc aaggagctca aaatggagga 2760 cgcggcagcc cggtggagcg ggcgggtgag tcacccacac aaaggaagag ggccttgccc 2820 ctcgccggcc gctgcttcct gtgaccccgt ggtctatcgg ccgcatagtc acctcgggct 2880 tctcttgagc accgctcgtc gcggcggggg gaggggatct aatggcgttg gagtttgttc 2940 acatttggtg ggtggagact agtcaggcca gcctggcgct ggaagtcatt cttggaattt 3000 gcccctttga gtttggagcg aggctaattc tcaagcctct tagcggttca aaggtatttt 3060 ctaaacccgt ttccaggtgt tgtgaaaacc accgctaatt caaagcaagc cgccacc 3117 <210> 817 <211> 2730 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 817 ataacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg gggtttgctg 60 ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt atacaagcaa 120 aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag tatatgaccc 180 tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac gcaaccccca 240 ctggttgggg cttggccata ggccatcagc gcatgcgtgg aacctttgtg tctcctctgc 300 cgatccatac tgcggaactc ctagccgctt gttttgctcg cacctggagt ggagcaaacc 360 tcatcgggac cgacaattct gtcgtactct cccgcaagtc atcatcgttt ccttggctgc 420 taggctgtgc tgccaactgg atcctgcgcg ggacgtcctt tgtttacgtc ccgtcggcgc 480 tgaatcccgc ggacgacccc tcccggggcc gcttggggct ctaccgcccg cttctccgtc 540 tgccgtaccg tccgaccacg gggcgcacct ctctttacgc ggactccccg tctgtgcctt 600 ctcatctgcc ggaccgtgtg cacttcgctt cacctctgca cgtcgcatgg aggccaccgt 660 gaacgcccac cggaacttgc ccaaggtctt gcataagagg actcttggac tttcagcaat 720 gtcatcatat tatccctaat acttgccacc ccactcttaa tcagtggtgg aagaacggtg 780 tcagaactgt ttgtttcaat tggccattta agtttagtag taaaagactg gttaatgata 840 acaatgcatc gtaaaacctt cagaaggaaa ggagaatgtt ttgtggacca ctttggtttt 900 cttttttgcg tgtggcagtt ttaagttatt agtttttaaa atcagtactt tttaatggaa 960 acaacttgac caaaaatttg tcacagaatt ttgagatcca ttaaaaaagt taaatgagaa 1020 acctgtgtgt tcctttggtc aacaccgaga catttaggtg aaagcatata ctgagattga 1080 gattaacttc ctgtgaaacc cagtgtctta gacaactgtg gcttgagcac cacctgttgg 1140 tattcattac aaacttgctc actacaataa atgaatttta agctttaaga tgaagtggca 1200 tttcttttaa cagttactat gttggaattg gttacaaatt ttggagtgga ctattgtata 1260 tatatatcag ttactgttat ggatcccacg tcactattgt atactctata ttatactcta 1320 tgttatactc tgtaatccta ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct 1380 cccgtgtctt gttatcacca tcaggtgaca tcctcgccca ggctgtcaat catgccggta 1440 tcgattccag tagcaccggc cccacgctga caacccactc ttgcagcgtt agcagcgccc 1500 ctcttaacaa gccgaccccc accagcgtcg cggttactaa cactcctctc cccggggcat 1560 ccgctactcc cgagctctcc tttggggccg ccaattgatt attgactagt tattaatagt 1620 aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta 1680 cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga 1740 cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt 1800 tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta 1860 ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg 1920 actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt 1980 tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc 2040 accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat 2100 gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct 2160 atataagcag agctcgttta gtgaaccgtc agatcctcac tctcttccgc atcgctgtct 2220 gcgagggcca gctgttgggc tcgcggttga ggacaaactc ttcgcggtct ttccagtact 2280 cttggatcgg aaacccgtcg gcctccgaac ggtactccgc caccgaggga cctgagcgag 2340 tccgcatcga ccggatcgga aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa 2400 ggtaggctga gcaccgtggc gggcggcagc gggtggcggt cggggttgtt tctggcggag 2460 gtgctgctga tgatgtaatt aaagtaggcg gtcttgagac ggcggatggt cgaggtgagg 2520 tgtggcaggc ttgagatcca gctgttgggg tgagtactcc ctctcaaaag cgggcattac 2580 ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccga 2640 tctggccata cacttgagtg acaatgacat ccactttgcc tttctctcca caggtgtcca 2700 ctcccaggtc caagtttaaa cgccgccacc 2730 <210> 818 <211> 3231 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 818 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg 780 aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg 840 ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagtcccc 900 attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg 960 aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagaa atcgataata 1020 tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta ttttattttt 1080 gagtcgggcg cgccaaaatg aagtgaagtt cctatacttt ctagagcgag ctcacgggga 1140 cagccccccc ccaaagcccc cagggatgta attacgtccc tcccccgcta gggggcagca 1200 gcgagccgcc cggggctccg ctccggtccg gcgctccccc cgcatccccg agccggcagc 1260 gtgcggggac agcccgggca cggggaaggt ggcacgggat cgctttcctc tgaacgcttc 1320 tcgctgctct ttgagcctgc agacacctgg ggggatacgg ggaaaaagct ttaggctgaa 1380 agagagattt agaatgacag gcgagctcac ggggacagcc cccccccaaa gcccccaggg 1440 atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg 1500 gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg 1560 aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca 1620 cctgggggga tacggggaaa aagcttgaaa cttgatctgt cgccgcaatt caagcttcgt 1680 gaggctccgg tgcccgtcag tgacctgcta tactctggag acgcctctcc cggccagagg 1740 agcaaggtat gcgggaggcg accaggagga tagcggggct gacgtcggga ggtggcctcc 1800 gtgggaagga cacccggatc ttgacacagc cttggcagcg gagtcaggaa gagtaggggt 1860 aggttctgga cgccctcttg gccagctcat cgccgcccca ccctctgctg gagcacagag 1920 taattcatac aaaaggaggg atcgccttcg caaggggaga gcccagggac cgtccctaaa 1980 ttctcacaga cccaaatccc tgtagccgcc ccacgacagc gcgaggagca tgcgcccagg 2040 gctgagcgcg ggtagatcag agcacacaag ctcacagtcc ccggcggtgg ggggaggggc 2100 gcgctgagcg ggggccaggg agctggcgcg gggcaaactg ggaaagtggt gtcgtgtgct 2160 ggctccgccc tcttcccgag ggtgggggag aacggtatat aagtgcggta gtcgccttgg 2220 acgttctttt tcgcaacggg tttgccgtca gaacgcaggt gagtggcggg tgtggcttcc 2280 gcgggccccg gagctggagc cctgctctga gcgggccggg ctgatatgcg agtgtcgtcc 2340 gcagggttta gctgtgagca ttcccacttc gagtggcggg cggtgcgggg gtgagagtgc 2400 gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct agcgtggtgt 2460 ccgccgccgc gtgccactcc ggccgcacta tgcgtttttt gtccttgctg ccctcgattg 2520 ccttccagca gcatgggcta acaaagggag ggtgtggggc tcactcttaa ggagcccatg 2580 aagcttacgt tggataggaa tggaagggca ggaggggcga ctggggcccg cccgccttcg 2640 gagcacatgt ccgacgccac ctggatgggg cgaggcctgt ggctttccga agcaatcggg 2700 cgtgagttta gcctacctgg gccatgtggc cctagcactg ggcacggtct ggcctggcgg 2760 tgccgcgttc ccttgcctcc caacaagggt gaggccgtcc cgcccggcac cagttgcttg 2820 cgcggaaaga tggccgctcc cggggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2880 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctt gcccctcgcc 2940 ggccgctgct tcctgtgacc ccgtggtcta tcggccgcat agtcacctcg ggcttctctt 3000 gagcaccgct cgtcgcggcg gggggagggg atctaatggc gttggagttt gttcacattt 3060 ggtgggtgga gactagtcag gccagcctgg cgctggaagt cattcttgga atttgcccct 3120 ttgagtttgg agcgaggcta attctcaagc ctcttagcgg ttcaaaggta ttttctaaac 3180 ccgtttccag gtgttgtgaa agccaccgct aattcaaagc aagccgccac c 3231 <210> 819 <211> 2985 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 819 ccgcctagga caacctttag attataaaat ctgtgaaagg ttaacaggca ttctgaatta 60 tgttggtcct tttactaaat gtggttatgc tgctctcctt cctttgtatc aagctacttc 120 gcgtacggca tttgtgtttt cttctctcta ccacatctgg ttgctgtccc tttatgctga 180 gttgtggcct gttgccaggc aacgaggcgt ggtgtgctct gtgtctgacg caaccccctc 240 tggttggggc atttgcacca cctatcaact catttccccg acgggcgctt ttgccctgcc 300 gatcgccacc gcggacgtca tcgccgcatg ccttgcgcgc tgctggacag gcgctcggct 360 gttaggcact gacaactcgg tggttctttc gggcaaactg acttcctttc cttggctgct 420 cgcctctgtt gccaactgga ttcttcgcgg gacgtcgttc tgctacgtgc cttcggcagc 480 gaatccggcg gaccttcctt ctcgaggcct tctgccggct ctgcatcccg tgccgactct 540 ccgcttccgt ccgcagctga gtcgcatctc cctttggccc gcctccccga tattatccct 600 aatacttgcc accccactct taatcagtgg tggaagaacg gtgtcagaac tgtttgtttc 660 aattggccat ttaagtttag tagtaaaaga ctggttaatg ataacaatgc atcgtaaaac 720 cttcagaagg aaaggagaat gttttgtgga ccactttggt tttctttttt gcgtgtggca 780 gttttaagtt attagttttt aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 840 ttgtcacaga attttgagat ccattaaaaa agttaaatga gaaacctgtg tgttcctttg 900 gtcaacaccg agacatttag gtgaaagcat atactgagat tgagattaac ttcctgtgaa 960 acccagtgtc ttagacaact gtggcttgag caccacctgt tggtattcat tacaaacttg 1020 ctcactacaa taaatgaatt ttaagcttta agatgaagtg gcatttcttt taacagttac 1080 tatgttggaa ttggttacaa attttggagt ggactattgt atatatatat cagttactgt 1140 tatggatccc acgtcactat tgtatactct atattatact ctatgttata ctctgtaatc 1200 ctactcaata aacgtgtcac gcctgtgaaa ccgtactaag tctcccgtgt cttgttatca 1260 ccatcaggtg acatcctcgc ccaggctgtc aatcatgccg gtatcgattc cagtagcacc 1320 ggccccacgc tgacaaccca ctcttgcagc gttagcagcg cccctcttaa caagccgacc 1380 cccaccagcg tcgcggttac taacactcct ctccccgggg catccgctac tcccgagctc 1440 gaattcgttt atcggccacc gaggccaaga tctggccgcc atatactgag tcattaggga 1500 ctttccaatg ggttttgccc agtacataag gtcaataggg gtgaatcaac aggaaagtcc 1560 cattggagcc aagtacactg agtcaatagg gactttccat tgggttttgc ccagtacaaa 1620 aggtcaatag ggggtgagtc aatgggtttt tcccattatt ggcacgtaca taaggtcaat 1680 aggggtgagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 1740 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 1800 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 1860 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 1920 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta gggaccggtt 1980 tgccgccaga acacaggtga ggggcgggtg tggcttccgc gggccgccga gctggaggtc 2040 ctgctccgag cgggccgggc cccgctgtcg tcggcgggga ttagctgcga gcattcccgc 2100 ttcgagttgc gggcggcgcg ggaggcagag tgcgaggcct agcggcaacc ccgtagcctc 2160 gcctcgtgtc cggcttgagg cctagcgtgg tgtccgcgcc gccgccgcgt gctactccgg 2220 ccgcactctg gtcttttttt tttttgttgt tgttgccctg ctgccttcga ttgccgttca 2280 gcaatagggg ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc ggagaggtca 2340 tggttgggga ggaatggagg gacaggagtg gcggctgggg cccgcccgcc ttcggagcac 2400 atgtccgacg ccacctggat ggggcgaggc ctggggtttt tcccgaagca accaggctgg 2460 ggttagcgtg ccgaggccat gtggccccag cacccggcac gatctggctt ggcggcgccg 2520 cgttgccctg cctccctaac tagggtgagg ccatcccgtc cggcaccagt tgcgtgcgtg 2580 gaaagatggc cgctcccggg ccctgttgca aggagctcaa aatggaggac gcggcagccc 2640 ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gcctggtccc tcaccggctg 2700 ctgcttcctg tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc ttttgagcac 2760 ggctagtcgc ggcgggggga ggggatgtaa tggcgttgga gtttgttcac atttggtggg 2820 tggagactag tcaggccagc ctggcgctgg aagtcatttt tggaatttgt ccccttgagt 2880 tttgagcgga gctaattctc gggcttctta gcggttcaaa ggtatctttt aaaccctttt 2940 ttaggtgttg tgaaaaccac cgctaattca aagcaagccg ccacc 2985 <210> 820 <211> 3083 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 820 ccgcctagga caacctttag attataaaat ctgtgaaagg ttaacaggca ttctgaatta 60 tgttggtcct tttactaaat gtggttatgc tgctctcctt cctttgtatc aagctacttc 120 gcgtacggca tttgtgtttt cttctctcta ccacatctgg ttgctgtccc tttatgctga 180 gttgtggcct gttgccaggc aacgaggcgt ggtgtgctct gtgtctgacg caaccccctc 240 tggttggggc atttgcacca cctatcaact catttccccg acgggcgctt ttgccctgcc 300 gatcgccacc gcggacgtca tcgccgcatg ccttgcgcgc tgctggacag gcgctcggct 360 gttaggcact gacaactcgg tggttctttc gggcaaactg acttcctttc cttggctgct 420 cgcctctgtt gccaactgga ttcttcgcgg gacgtcgttc tgctacgtgc cttcggcagc 480 gaatccggcg gaccttcctt ctcgaggcct tctgccggct ctgcatcccg tgccgactct 540 ccgcttccgt ccgcagctga gtcgcatctc cctttggccc gcctccccgg ggggaggcta 600 actgaaacac ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga 660 cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg 720 ctggcactct gtcgataccc caccgagtcc ccattggggc caatacgccc gcgtttcttc 780 cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag ccaacgtcgg 840 ggcggcaggc cctgccatag aaatcgataa tatatggtag ggttcatagc cagagtaacc 900 ttttttttta atttttattt tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag 960 ttcctatact ttctagagcg agctcacggg gacagccccc ccccaaagcc cccagggatg 1020 taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc 1080 cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag 1140 gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct 1200 ggggggatac ggggaaaaag ctttaggctg aaagagagat ttagaatgac aggcgagctc 1260 acggggacag ccccccccca aagcccccag ggatgtaatt acgtccctcc cccgctaggg 1320 ggcagcagcg agccgcccgg ggctccgctc cggtccggcg ctccccccgc atccccgagc 1380 cggcagcgtg cggggacagc ccgggcacgg ggaaggtggc acgggatcgc tttcctctga 1440 acgcttctcg ctgctctttg agcctgcaga cacctggggg gatacgggga aaaagcttga 1500 aacttgatct gtcgccgcaa ttcaagcttc gtgaggctcc ggtgcccgtc agtgacctgc 1560 tatactctgg agacgcctct cccggccaga ggagcaaggt atgcgggagg cgaccaggag 1620 gatagcgggg ctgacgtcgg gaggtggcct ccgtgggaag gacacccgga tcttgacaca 1680 gccttggcag cggagtcagg aagagtaggg gtaggttctg gacgccctct tggccagctc 1740 atcgccgccc caccctctgc tggagcacag agtaattcat acaaaaggag ggatcgcctt 1800 cgcaagggga gagcccaggg accgtcccta aattctcaca gacccaaatc cctgtagccg 1860 ccccacgaca gcgcgaggag catgcgccca gggctgagcg cgggtagatc agagcacaca 1920 agctcacagt ccccggcggt ggggggaggg gcgcgctgag cgggggccag ggagctggcg 1980 cggggcaaac tgggaaagtg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg 2040 agaacggtat ataagtgcgg tagtcgcctt ggacgttctt tttcgcaacg ggtttgccgt 2100 cagaacgcag gtgagtggcg ggtgtggctt ccgcgggccc cggagctgga gccctgctct 2160 gagcgggccg ggctgatatg cgagtgtcgt ccgcagggtt tagctgtgag cattcccact 2220 tcgagtggcg ggcggtgcgg gggtgagagt gcgaggccta gcggcaaccc cgtagcctcg 2280 cctcgtgtcc ggcttgaggc ctagcgtggt gtccgccgcc gcgtgccact ccggccgcac 2340 tatgcgtttt ttgtccttgc tgccctcgat tgccttccag cagcatgggc taacaaaggg 2400 agggtgtggg gctcactctt aaggagccca tgaagcttac gttggatagg aatggaaggg 2460 caggaggggc gactggggcc cgcccgcctt cggagcacat gtccgacgcc acctggatgg 2520 ggcgaggcct gtggctttcc gaagcaatcg ggcgtgagtt tagcctacct gggccatgtg 2580 gccctagcac tgggcacggt ctggcctggc ggtgccgcgt tcccttgcct cccaacaagg 2640 gtgaggccgt cccgcccggc accagttgct tgcgcggaaa gatggccgct cccggggccc 2700 tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac 2760 ccacacaaag gaagagggcc ttgcccctcg ccggccgctg cttcctgtga ccccgtggtc 2820 tatcggccgc atagtcacct cgggcttctc ttgagcaccg ctcgtcgcgg cggggggagg 2880 ggatctaatg gcgttggagt ttgttcacat ttggtgggtg gagactagtc aggccagcct 2940 ggcgctggaa gtcattcttg gaatttgccc ctttgagttt ggagcgaggc taattctcaa 3000 gcctcttagc ggttcaaagg tattttctaa acccgtttcc aggtgttgtg aaagccaccg 3060 ctaattcaaa gcaagccgcc acc 3083 <210> 821 <211> 3220 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 821 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcata ttatccctaa tacttgccac cccactctta atcagtggtg 780 gaagaacggt gtcagaactg tttgtttcaa ttggccattt aagtttagta gtaaaagact 840 ggttaatgat aacaatgcat cgtaaaacct tcagaaggaa aggagaatgt tttgtggacc 900 actttggttt tcttttttgc gtgtggcagt tttaagttat tagtttttaa aatcagtact 960 ttttaatgga aacaacttga ccaaaaattt gtcacagaat tttgagatcc attaaaaaag 1020 ttaaatgaga aacctgtgtg ttcctttggt caacaccgag acatttaggt gaaagcatat 1080 actgagattg agattaactt cctgtgaaac ccagtgtctt agacaactgt ggcttgagca 1140 ccacctgttg gtattcatta caaacttgct cactacaata aatgaatttt aagctttaag 1200 atgaagtggc atttctttta acagttacta tgttggaatt ggttacaaat tttggagtgg 1260 actattgtat atatatatca gttactgtta tggatcccac gtcactattg tatactctat 1320 attatactct atgttatact ctgtaatcct actcaataaa cgtgtcacgc ctgtgaaacc 1380 gtactaagtc tcccgtgtct tgttatcacc atcaggtgac atcctcgccc aggctgtcaa 1440 tcatgccggt atcgattcca gtagcaccgg ccccacgctg acaacccact cttgcagcgt 1500 tagcagcgcc cctcttaaca agccgacccc caccagcgtc gcggttacta acactcctct 1560 ccccggggca tccgctactc ccgagctcga attcgtttat cggccaccga ggccaagatc 1620 tggccgccaa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt 1680 gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca 1740 atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc 1800 aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta 1860 catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac 1920 caagtcattg ggtttttcca gccaatttat aaaacgccat gtactttccc accattgacg 1980 tcaatgggct attgaaacta atgcaacgtg acctttaaac ggtactttcc catagctgat 2040 taatgggaaa gtaccgttct cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa 2100 aacgtaacac cgccccggtt ttcccctgga aattccatat tggcacgcat tctattggct 2160 gagctgcgtt ctacgtgggt ataagaggcg cgaccagcgt cggtagggac cggtttgccg 2220 ccagaacaca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg aggtcctgct 2280 ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt cccgcttcga 2340 gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta gcctcgcctc 2400 gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac tccggccgca 2460 ctctggtctt tttttttttt gttgttgttg ccctgctgcc ttcgattgcc gttcagcaat 2520 aggggctaac aaagggaggg tgcggggctt gctcgcccgg agcccggaga ggtcatggtt 2580 ggggaggaat ggagggacag gagtggcggc tggggcccgc ccgccttcgg agcacatgtc 2640 cgacgccacc tggatggggc gaggcctggg gtttttcccg aagcaaccag gctggggtta 2700 gcgtgccgag gccatgtggc cccagcaccc ggcacgatct ggcttggcgg cgccgcgttg 2760 ccctgcctcc ctaactaggg tgaggccatc ccgtccggca ccagttgcgt gcgtggaaag 2820 atggccgctc ccgggccctg ttgcaaggag ctcaaaatgg aggacgcggc agcccggtgg 2880 agcgggcggg tgagtcaccc acacaaagga agagggcctg gtccctcacc ggctgctgct 2940 tcctgtgacc ccgtggtcct atcggccgca atagtcacct cgggcttttg agcacggcta 3000 gtcgcggcgg ggggagggga tgtaatggcg ttggagtttg ttcacatttg gtgggtggag 3060 actagtcagg ccagcctggc gctggaagtc atttttggaa tttgtcccct tgagttttga 3120 gcggagctaa ttctcgggct tcttagcggt tcaaaggtat cttttaaacc cttttttagg 3180 tgttgtgaaa accaccgcta attcaaagca agccgccacc 3220 <210> 822 <211> 3072 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 822 ccgcctagga caacctttag attataaaat ctgtgaaagg ttaacaggca ttctgaatta 60 tgttggtcct tttactaaat gtggttatgc tgctctcctt cctttgtatc aagctacttc 120 gcgtacggca tttgtgtttt cttctctcta ccacatctgg ttgctgtccc tttatgctga 180 gttgtggcct gttgccaggc aacgaggcgt ggtgtgctct gtgtctgacg caaccccctc 240 tggttggggc atttgcacca cctatcaact catttccccg acgggcgctt ttgccctgcc 300 gatcgccacc gcggacgtca tcgccgcatg ccttgcgcgc tgctggacag gcgctcggct 360 gttaggcact gacaactcgg tggttctttc gggcaaactg acttcctttc cttggctgct 420 cgcctctgtt gccaactgga ttcttcgcgg gacgtcgttc tgctacgtgc cttcggcagc 480 gaatccggcg gaccttcctt ctcgaggcct tctgccggct ctgcatcccg tgccgactct 540 ccgcttccgt ccgcagctga gtcgcatctc cctttggccc gcctccccga tattatccct 600 aatacttgcc accccactct taatcagtgg tggaagaacg gtgtcagaac tgtttgtttc 660 aattggccat ttaagtttag tagtaaaaga ctggttaatg ataacaatgc atcgtaaaac 720 cttcagaagg aaaggagaat gttttgtgga ccactttggt tttctttttt gcgtgtggca 780 gttttaagtt attagttttt aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 840 ttgtcacaga attttgagat ccattaaaaa agttaaatga gaaacctgtg tgttcctttg 900 gtcaacaccg agacatttag gtgaaagcat atactgagat tgagattaac ttcctgtgaa 960 acccagtgtc ttagacaact gtggcttgag caccacctgt tggtattcat tacaaacttg 1020 ctcactacaa taaatgaatt ttaagcttta agatgaagtg gcatttcttt taacagttac 1080 tatgttggaa ttggttacaa attttggagt ggactattgt atatatatat cagttactgt 1140 tatggatccc acgtcactat tgtatactct atattatact ctatgttata ctctgtaatc 1200 ctactcaata aacgtgtcac gcctgtgaaa ccgtactaag tctcccgtgt cttgttatca 1260 ccatcaggtg acatcctcgc ccaggctgtc aatcatgccg gtatcgattc cagtagcacc 1320 ggccccacgc tgacaaccca ctcttgcagc gttagcagcg cccctcttaa caagccgacc 1380 cccaccagcg tcgcggttac taacactcct ctccccgggg catccgctac tcccgagctc 1440 gaattcgttt atcggccacc gaggccaaga tctggccgcc aacttacggt aaatggcccg 1500 cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata 1560 gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc 1620 cacttggcag tacatcaagt gtatcatatg ccaagtccgc cccctattga cgtcaatgac 1680 ggtaaatggc ccgcctggca ttatgcccag tacatgacct tacgggactt tcctacttgg 1740 cagtacatct acgtattagt catcgctatt accaagtcat tgggtttttc cagccaattt 1800 ataaaacgcc atgtactttc ccaccattga cgtcaatggg ctattgaaac taatgcaacg 1860 tgacctttaa acggtacttt cccatagctg attaatggga aagtaccgtt ctcgagccaa 1920 tacacgtcaa tgggaagtga aagggcagcc aaaacgtaac accgccccgg ttttcccctg 1980 gaaattccat attggcacgc attctattgg ctgagctgcg ttctacgtgg gtataagagg 2040 cgcgaccagc gtcggtaggg accggtttgc cgccagaaca caggtgaggg gcgggtgtgg 2100 cttccgcggg ccgccgagct ggaggtcctg ctccgagcgg gccgggcccc gctgtcgtcg 2160 gcggggatta gctgcgagca ttcccgcttc gagttgcggg cggcgcggga ggcagagtgc 2220 gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct agcgtggtgt 2280 ccgcgccgcc gccgcgtgct actccggccg cactctggtc tttttttttt ttgttgttgt 2340 tgccctgctg ccttcgattg ccgttcagca ataggggcta acaaagggag ggtgcggggc 2400 ttgctcgccc ggagcccgga gaggtcatgg ttggggagga atggagggac aggagtggcg 2460 gctggggccc gcccgccttc ggagcacatg tccgacgcca cctggatggg gcgaggcctg 2520 gggtttttcc cgaagcaacc aggctggggt tagcgtgccg aggccatgtg gccccagcac 2580 ccggcacgat ctggcttggc ggcgccgcgt tgccctgcct ccctaactag ggtgaggcca 2640 tcccgtccgg caccagttgc gtgcgtggaa agatggccgc tcccgggccc tgttgcaagg 2700 agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac ccacacaaag 2760 gaagagggcc tggtccctca ccggctgctg cttcctgtga ccccgtggtc ctatcggccg 2820 caatagtcac ctcgggcttt tgagcacggc tagtcgcggc ggggggaggg gatgtaatgg 2880 cgttggagtt tgttcacatt tggtgggtgg agactagtca ggccagcctg gcgctggaag 2940 tcatttttgg aatttgtccc cttgagtttt gagcggagct aattctcggg cttcttagcg 3000 gttcaaaggt atcttttaaa ccctttttta ggtgttgtga aaaccaccgc taattcaaag 3060 caagccgcca cc 3072 <210> 823 <211> 2492 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 823 ccgcctagga caacctttag attataaaat ctgtgaaagg ttaacaggca ttctgaatta 60 tgttggtcct tttactaaat gtggttatgc tgctctcctt cctttgtatc aagctacttc 120 gcgtacggca tttgtgtttt cttctctcta ccacatctgg ttgctgtccc tttatgctga 180 gttgtggcct gttgccaggc aacgaggcgt ggtgtgctct gtgtctgacg caaccccctc 240 tggttggggc atttgcacca cctatcaact catttccccg acgggcgctt ttgccctgcc 300 gatcgccacc gcggacgtca tcgccgcatg ccttgcgcgc tgctggacag gcgctcggct 360 gttaggcact gacaactcgg tggttctttc gggcaaactg acttcctttc cttggctgct 420 cgcctctgtt gccaactgga ttcttcgcgg gacgtcgttc tgctacgtgc cttcggcagc 480 gaatccggcg gaccttcctt ctcgaggcct tctgccggct ctgcatcccg tgccgactct 540 ccgcttccgt ccgcagctga gtcgcatctc cctttggccc gcctccccgg ggggaggcta 600 actgaaacac ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga 660 cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg 720 ctggcactct gtcgataccc caccgagtcc ccattggggc caatacgccc gcgtttcttc 780 cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag ccaacgtcgg 840 ggcggcaggc cctgccatag aaatcgataa tatatggtag ggttcatagc cagagtaacc 900 ttttttttta atttttattt tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag 960 ttcctatact ttctagagcg agctcacggg gacagccccc ccccaaagcc cccagggatg 1020 taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc 1080 cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag 1140 gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct 1200 ggggggatac ggggaaaaag ctttaggctg aaagagagat ttagaatgac aggcgagctc 1260 acggggacag ccccccccca aagcccccag ggatgtaatt acgtccctcc cccgctaggg 1320 ggcagcagcg agccgcccgg ggctccgctc cggtccggcg ctccccccgc atccccgagc 1380 cggcagcgtg cggggacagc ccgggcacgg ggaaggtggc acgggatcgc tttcctctga 1440 acgcttctcg ctgctctttg agcctgcaga cacctggggg gatacgggga aaaagcttga 1500 aacttgatct gtcgccgcaa ttcaagcttc gtgaggctcc ggtgcccgtc agtgacctgc 1560 tatactctgg agacgactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 1620 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 1680 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 1740 tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 1800 ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc 1860 tattaccatg ctgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc 1920 acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 1980 tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag 2040 gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg 2100 gagacgccat ccacgctgtt ttgacctcca tagaagatac cgggaccgat ccagcctccg 2160 cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacc ctggcagaac 2220 tcggtaagtc tgttgacatg tatgtgatgt atactaacct gcatgggacg tggatttact 2280 tgtgtatgtc agatagagta aagattaact cttgcatgtg agcggggcat cgagatagcg 2340 ataaatgagt caggaggacg gagcctctgc taaccatgtt catgccttct tctttttcct 2400 acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaatttca 2460 ccgtccttga cacgaagttt gctcgagcca cc 2492 <210> 824 <211> 2464 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 824 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctataga caagcagggg atggcggggc tgacgtcggg aggtggcctc 1020 cacgggaagg gacacccgga tctcgacaca gccttggcag tggagtcagg aagggtagga 1080 cagattctgg acgccctctt ggccagtcct caccgcccca cccccgatgg agccgagagt 1140 aattcataca aaaggaggga tcgccttcgc ccctgggaat cccagggacc gtcgctaaat 1200 tctggccggc ctcccagccc ggaaccgctg tgcccgccca gcgcggcggg aggagcctgc 1260 gcctagggcg gatcgcgggt cggcgggaga gcacaagccc acagtccccg gcggtggggg 1320 aggggcgcgc tgagcggggg cccgggagcc agcgcggggc aaactgggaa agtggtgtcg 1380 tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtataaaagt gcggtagtcg 1440 cgttggacgt tctttttcgc aacgggtttg ccgtcagaac gcaggtgagt ggcgggtgtg 1500 gcctccgcgg gcccgggctc cctcctttga gcggggtcgg accgccgtgc gggtgtcgtc 1560 ggccgggctt ctctgcgagc gttcccgccc tggatggcgg gctgtgcggg agggcgaggg 1620 ggggaggcct ggcggcggcc ccggagcctc gcctcgtgtc gggcgtgagg cctagcgtgg 1680 cttccgcccc gccgcgtgcc accgcggccg cgctttgctg tctgcccggc tgccctcgat 1740 tgcctgcccg cggcccgggc caacaaaggg agggcgtgga gctggctggt agggagcccc 1800 gtagtccgca tgtcgggcag ggagagcggc agcagtcggg ggggggaccg ggcccgcccg 1860 tcccgcagca catgtccgac gccgcctgga cgggtagcgg cctgtgtcct gataaggcgg 1920 ccgggcggtg ggttttagat gccgggttca ggtggccccg ggtcccggcc cggtctggcc 1980 agtaccccgt agtggcttag ctccgaggag ggcgagcccg cccgcccggc accagttgcg 2040 tgcgcggaaa gatggccgct cccgggccct gtagcaagga gctcaaaatg gaggacgcgg 2100 cagcccggcg gagcggggcg ggtgagtcac ccacacaaag gaagagggcc ttgcccctcg 2160 ccggccgctg cttcctgtga ccccgtggtg taccggccgc acttcagtca ccccgggcgc 2220 tctttcggag caccgctggc ctccgctggg ggaggggatc tgtctaatgg cgttggagtt 2280 tgctcacatt tggtgggtgg agactgtagc caggccagcc tggccatgga agtaattctt 2340 ggaatttgcc cattttgagt ttggagcgaa gctgattgac aaagctgctt agccgttcaa 2400 aggtattctt cgaacttttt ttttaaggtg ttgtgaaaac caccgctaat tcaaatccgc 2460 cacc 2464 <210> 825 <211> 3050 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 825 ccgcctagga caacctttag attataaaat ctgtgaaagg ttaacaggca ttctgaatta 60 tgttggtcct tttactaaat gtggttatgc tgctctcctt cctttgtatc aagctacttc 120 gcgtacggca tttgtgtttt cttctctcta ccacatctgg ttgctgtccc tttatgctga 180 gttgtggcct gttgccaggc aacgaggcgt ggtgtgctct gtgtctgacg caaccccctc 240 tggttggggc atttgcacca cctatcaact catttccccg acgggcgctt ttgccctgcc 300 gatcgccacc gcggacgtca tcgccgcatg ccttgcgcgc tgctggacag gcgctcggct 360 gttaggcact gacaactcgg tggttctttc gggcaaactg acttcctttc cttggctgct 420 cgcctctgtt gccaactgga ttcttcgcgg gacgtcgttc tgctacgtgc cttcggcagc 480 gaatccggcg gaccttcctt ctcgaggcct tctgccggct ctgcatcccg tgccgactct 540 ccgcttccgt ccgcagctga gtcgcatctc cctttggccc gcctccccgg ggggaggcta 600 actgaaacac ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga 660 cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg 720 ctggcactct gtcgataccc caccgagtcc ccattggggc caatacgccc gcgtttcttc 780 cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag ccaacgtcgg 840 ggcggcaggc cctgccatag aaatcgataa tatatggtag ggttcatagc cagagtaacc 900 ttttttttta atttttattt tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag 960 ttcctatact ttctagagcg agctcacggg gacagccccc ccccaaagcc cccagggatg 1020 taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc 1080 cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag 1140 gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct 1200 ggggggatac ggggaaaaag ctttaggctg aaagagagat ttagaatgac aggcgagctc 1260 acggggacag ccccccccca aagcccccag ggatgtaatt acgtccctcc cccgctaggg 1320 ggcagcagcg agccgcccgg ggctccgctc cggtccggcg ctccccccgc atccccgagc 1380 cggcagcgtg cggggacagc ccgggcacgg ggaaggtggc acgggatcgc tttcctctga 1440 acgcttctcg ctgctctttg agcctgcaga cacctggggg gatacgggga aaaagcttga 1500 aacttgatct gtcgccgcaa ttcaagcttc gtgaggctcc ggtgcccgtc agtgacctgc 1560 tatagacaag caggggatgg cggggctgac gtcgggaggt ggcctccacg ggaagggaca 1620 cccggatctc gacacagcct tggcagtgga gtcaggaagg gtaggacaga ttctggacgc 1680 cctcttggcc agtcctcacc gccccacccc cgatggagcc gagagtaatt catacaaaag 1740 gagggatcgc cttcgcccct gggaatccca gggaccgtcg ctaaattctg gccggcctcc 1800 cagcccggaa ccgctgtgcc cgcccagcgc ggcgggagga gcctgcgcct agggcggatc 1860 gcgggtcggc gggagagcac aagcccacag tccccggcgg tgggggaggg gcgcgctgag 1920 cgggggcccg ggagccagcg cggggcaaac tgggaaagtg gtgtcgtgtg ctggctccgc 1980 cctcttcccg agggtggggg agaacggtat aaaagtgcgg tagtcgcgtt ggacgttctt 2040 tttcgcaacg ggtttgccgt cagaacgcag gtgagtggcg ggtgtggcct ccgcgggccc 2100 gggctccctc ctttgagcgg ggtcggaccg ccgtgcgggt gtcgtcggcc gggcttctct 2160 gcgagcgttc ccgccctgga tggcgggctg tgcgggaggg cgaggggggg aggcctggcg 2220 gcggccccgg agcctcgcct cgtgtcgggc gtgaggccta gcgtggcttc cgccccgccg 2280 cgtgccaccg cggccgcgct ttgctgtctg cccggctgcc ctcgattgcc tgcccgcggc 2340 ccgggccaac aaagggaggg cgtggagctg gctggtaggg agccccgtag tccgcatgtc 2400 gggcagggag agcggcagca gtcggggggg ggaccgggcc cgcccgtccc gcagcacatg 2460 tccgacgccg cctggacggg tagcggcctg tgtcctgata aggcggccgg gcggtgggtt 2520 ttagatgccg ggttcaggtg gccccgggtc ccggcccggt ctggccagta ccccgtagtg 2580 gcttagctcc gaggagggcg agcccgcccg cccggcacca gttgcgtgcg cggaaagatg 2640 gccgctcccg ggccctgtag caaggagctc aaaatggagg acgcggcagc ccggcggagc 2700 ggggcgggtg agtcacccac acaaaggaag agggccttgc ccctcgccgg ccgctgcttc 2760 ctgtgacccc gtggtgtacc ggccgcactt cagtcacccc gggcgctctt tcggagcacc 2820 gctggcctcc gctgggggag gggatctgtc taatggcgtt ggagtttgct cacatttggt 2880 gggtggagac tgtagccagg ccagcctggc catggaagta attcttggaa tttgcccatt 2940 ttgagtttgg agcgaagctg attgacaaag ctgcttagcc gttcaaaggt attcttcgaa 3000 cttttttttt aaggtgttgt gaaaaccacc gctaattcaa atccgccacc 3050 <210> 826 <211> 3198 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 826 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcacctggag 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt catcatcgtt 420 tccttggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg 780 aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg 840 ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagtcccc 900 attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg 960 aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagaa atcgataata 1020 tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta ttttattttt 1080 gagtcgggcg cgccaaaatg aagtgaagtt cctatacttt ctagagcgag ctcacgggga 1140 cagccccccc ccaaagcccc cagggatgta attacgtccc tcccccgcta gggggcagca 1200 gcgagccgcc cggggctccg ctccggtccg gcgctccccc cgcatccccg agccggcagc 1260 gtgcggggac agcccgggca cggggaaggt ggcacgggat cgctttcctc tgaacgcttc 1320 tcgctgctct ttgagcctgc agacacctgg ggggatacgg ggaaaaagct ttaggctgaa 1380 agagagattt agaatgacag gcgagctcac ggggacagcc cccccccaaa gcccccaggg 1440 atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg 1500 gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg 1560 aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca 1620 cctgggggga tacggggaaa aagcttgaaa cttgatctgt cgccgcaatt caagcttcgt 1680 gaggctccgg tgcccgtcag tgacctgcta tagacaagca ggggatggcg gggctgacgt 1740 cgggaggtgg cctccacggg aagggacacc cggatctcga cacagccttg gcagtggagt 1800 caggaagggt aggacagatt ctggacgccc tcttggccag tcctcaccgc cccacccccg 1860 atggagccga gagtaattca tacaaaagga gggatcgcct tcgcccctgg gaatcccagg 1920 gaccgtcgct aaattctggc cggcctccca gcccggaacc gctgtgcccg cccagcgcgg 1980 cgggaggagc ctgcgcctag ggcggatcgc gggtcggcgg gagagcacaa gcccacagtc 2040 cccggcggtg ggggaggggc gcgctgagcg ggggcccggg agccagcgcg gggcaaactg 2100 ggaaagtggt gtcgtgtgct ggctccgccc tcttcccgag ggtgggggag aacggtataa 2160 aagtgcggta gtcgcgttgg acgttctttt tcgcaacggg tttgccgtca gaacgcaggt 2220 gagtggcggg tgtggcctcc gcgggcccgg gctccctcct ttgagcgggg tcggaccgcc 2280 gtgcgggtgt cgtcggccgg gcttctctgc gagcgttccc gccctggatg gcgggctgtg 2340 cgggagggcg agggggggag gcctggcggc ggccccggag cctcgcctcg tgtcgggcgt 2400 gaggcctagc gtggcttccg ccccgccgcg tgccaccgcg gccgcgcttt gctgtctgcc 2460 cggctgccct cgattgcctg cccgcggccc gggccaacaa agggagggcg tggagctggc 2520 tggtagggag ccccgtagtc cgcatgtcgg gcagggagag cggcagcagt cggggggggg 2580 accgggcccg cccgtcccgc agcacatgtc cgacgccgcc tggacgggta gcggcctgtg 2640 tcctgataag gcggccgggc ggtgggtttt agatgccggg ttcaggtggc cccgggtccc 2700 ggcccggtct ggccagtacc ccgtagtggc ttagctccga ggagggcgag cccgcccgcc 2760 cggcaccagt tgcgtgcgcg gaaagatggc cgctcccggg ccctgtagca aggagctcaa 2820 aatggaggac gcggcagccc ggcggagcgg ggcgggtgag tcacccacac aaaggaagag 2880 ggccttgccc ctcgccggcc gctgcttcct gtgaccccgt ggtgtaccgg ccgcacttca 2940 gtcaccccgg gcgctctttc ggagcaccgc tggcctccgc tgggggaggg gatctgtcta 3000 atggcgttgg agtttgctca catttggtgg gtggagactg tagccaggcc agcctggcca 3060 tggaagtaat tcttggaatt tgcccatttt gagtttggag cgaagctgat tgacaaagct 3120 gcttagccgt tcaaaggtat tcttcgaact ttttttttaa ggtgttgtga aaaccaccgc 3180 taattcaaat ccgccacc 3198 <210> 827 <211> 2165 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 827 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaacg gtccgaattt caaagtcttt ttcctattga 780 cctacaaggt tttcaagaat catgttgtaa gcaactgtgt tctgaggaat ctatgtttaa 840 aaacccatcc gtggatcttg gcccagggtc cagagactga gctagccacg ccccggccgc 900 gccgcagcca ctcccacggc agttcaagtg ttaagtccca aagaccgcgc tctgtgcatg 960 cgcagacccg tccacagctg gctcctagcc aacccggccg gacgagcacc cggcgccgtc 1020 acgtgacgca cccaaccggc gtcgacctat aaaaggccgg gcgttgacgt cagcgttctc 1080 ttccgccgca gccgccgcca tcgtcggcgc gcttccctgt tcacctctga ctctgagaat 1140 ccgtcgccat ccgccaggtg agtctcctcg gctccgctag actcggggac cgagaggaat 1200 ctctggggca gcgggacgtg gctgtagcgg gacgctgaga gggacgggag gaagagacat 1260 ggctgccctg gcccgggcgg caggacgtgg tcgggccgcg gcgccatatc tgcgcgtccc 1320 tgagggcctt gggagtgtca actgccgagg tcggggtgtt ttcttgaagt ccttcaactc 1380 cccgcggccg ccggggtgac tgcgggaggg gttgtgcttg gtgatgtggc agcgggcaaa 1440 gcgccgtccc cgcgcccctg gtgacgggcg gagggtgtcc tcgggaggtg acagcctgta 1500 gggctggctt ccttggacac ctccagtggg ctgaacgcct tccgggccct ttccggtagc 1560 ccccgtgtct gttttctatc tgagttcaca cgtgagcacc ggtccccata atctaagaaa 1620 gtggctcact gggcctagtg gcgcattgtg gcctttgatc cgggctttga ccttggcgca 1680 cagcacccag tggtttgggg aagaggtgtg tgtagcagag gaggtttttt cgtgctttgg 1740 tcccaatcaa tccggcatct ttgcagtgcc gaggtggccg tgcaccttgg ctttgaattc 1800 ttgtgctgag gttatgtgac ttgagcctca agatagggtg ttctagcaca ggcttgctct 1860 taagtgtcgc agttgtcggt ttcggcgttt gtttagagct gtggacacat ctgtgaactt 1920 ttgatgctta tttcagaggt cctgggttgt acgtttgagt cacactgtga gctcagctcc 1980 aatcttgggc cgacatctgg ttcctgcccc tgctgtgggg tgctattgac ccaccgatgc 2040 ctgccaagtt gggttcccag aatcagcctg gctgcccatc cccccaccac aggtgaactt 2100 cgtctcaagc ttccttcttc tttttcctag aagctcagaa taaacgctca actttggccg 2160 ccacc 2165 <210> 828 <211> 2188 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 828 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaggatccaa cttctaagtc cgttttttat tgatctaaaa 720 ggccttttgc gaatcatctt gaaggcaatc gcgttctgag ccacctcagc tttggcacac 780 agcgcgggga ctgtcgcgag gggtttaggg cccaagcagg acacaccccg aaatctccgc 840 agccaccccc accccacgcc cccggctctt gagggttaaa tcgcaggcgc tggttctcgc 900 acgcgcacat catcccgcag gcgagcccca gcacccagcc cagggtgcgc gcgcgccgtc 960 acgtgacacg cccaaccggc gtcgccgtat aaaagcgcgg gcgttgacgt cagcgttctc 1020 ttccgccgca gccgccgcca tcgtcggcgc ccctcgcact tctcctgtgc ccgtgagaat 1080 ccgtcgccat ccgccaggtg agtgaccccg gagcggcggt gctcggggcc ggagtcggta 1140 cctcggggct gcgggacgtg tcggtggcgg tccgcggagg ccggcctggg aggagacatg 1200 gctgccgggg cggcgggacg tggacggacg gggcggctgg cgccatgtct gcgcgtcggg 1260 ctgtggcctc ggcacggcgg ccgttgtccc ctcggcggac ggtgctgatt tggcagtggg 1320 cacagccagg cctctggccg ccctcgggcg tgggatcgct ggtcccgtcc ccggcggagg 1380 gccagcgtcc ctttacgagg tgacagccgg gtgggcggac ttccgtttgc acatccgcgt 1440 cccctgtggc cggcctccgc gcgtcacgtc gctgctgtag gaccccctcc tgaacggtga 1500 cgtgctccct gctaaccaaa tggattccga aggtagcctg ggcaagggct ctcgcatccc 1560 gccatgtgga acccgctggc tttgggtggc gcaaagcgtg tcccatgccg agcgtctgga 1620 ggttctgtgc ctccacacgt gtggacccat cgagttgtca tgagtagtgt cctgctgagg 1680 ttcccacgca cttctaggca ctgcttgctt ggctgtgaag ctggggtggc aggcgcagtt 1740 ttgttgcctg tggatgcgtt ggaagattgg gggcctttgg ttattgcggt ggtgactgtc 1800 tttgagatag ggtttcacgt agcccaggct tgctcaggtg gttagttcag ggtttgttta 1860 gttagggctg gacttctgac gtgctggctg tggactcttg atctgtatgc taacgaggtg 1920 cttgggcttg caggctcgag tcaccgcgga ctcactgttc cttatgaatg acaaccgagg 1980 ctccatcttg ggctgacggt cgtggttgta gtggctgtgt gcgcactgga gtgttgtgtg 2040 ggcaggccac ggccacgcgt gggaaacgac atgctgctgc ctgcagtttg ctcagctgcc 2100 cctcccccat cccaggtgaa cttcgtctca agcttccttc ttctttttcc tagaagctca 2160 gaataaacgc tcaactttgg ccgccacc 2188 <210> 829 <211> 1695 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 829 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaaaatcgat aatatatggt agggttcata gccagagtaa 720 cctttttttt taatttttat tttattttat ttttgagtcg ggcgcgccaa aatgaagtga 780 agttcctata ctttctagac gaagaacaac gaggagaaga tcctcaactt ttccgcagcc 840 ttttcaataa tggggagagg ttcgatgatg cagtggcagg gtgacccaca cttctccatt 900 tcccctgttc tcccatttta ctcgggaagc agcattcagg tttctgggtc ctggatgtcc 960 ttggtgcaca ctccaaggac tcctcgtcct taagttcata gtctgtattc cctgagtcct 1020 atcctgggaa ccatcacccg gtcacctcct gagcggggca atctcagctc ccctccccct 1080 atcagttcgg agcccacacg cttggtgcgt gcacatttca aaaatgaggc gggtccaaag 1140 agagggagga ggggaaatga gagaggccca gctactcgcg gctttacggg tgcacgtagc 1200 tcaggcctct gcgcccttga gctaggactg gataagcagg gcgggaggcg gggcgcgcgt 1260 catcagctcc cccccaccat ccgggttcct ataaatacgg actgcagccc tccctggtgc 1320 tctctgctcc tccctgttcc agagtcggcc gcatcttctt gtgcagtgcc aggtgaaaat 1380 cgcggagtgg gccgcaggag gccggggaca gtcggaaact gggaagggga gtgggcactg 1440 tacgggtcta gggatgctgg tgcgaagtgt gcaagccgga cccaggctcc gcattgcagg 1500 ggggggatga tggaggacgt gatggggcgc acggcgggaa tggaggcggg gtgggggagg 1560 ggactgcctg gtgtccttcg ggccacgcta atctcatttt cttctcctgc agcctcgtcc 1620 cgtagacaaa cgtctcaagc ttccttcttc tttttcctag aagctcagaa taaacgctca 1680 actttggccg ccacc 1695 <210> 830 <211> 1396 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 830 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaaa atcgataata tatggtaggg ttcatagcca 780 gagtaacctt tttttttaat ttttatttta ttttattttt gagtcgggcg cgccaaaatg 840 aagtgaagtt cctatacttt ctagacgggg ttggggttgc gccttttcca aggcagccct 900 gggtttgcgc agggacgcgg ctgctctggg cgtggttccg ggaaacgcag cggcgccgac 960 cctgggcctc gcacattctt cacgtccgtt cgcagcgtca cccggatctt cgccgctacc 1020 cttgtgggcc ccccggcgac gcttcctcgt ccgcccctaa gtcgggaagg ttccttgcgg 1080 ttcgcggcgt gccggacgtg acaaacggaa gccgcacgac tcactagtac cctcgcagac 1140 ggacagcgcc agggagcaat ggcagcgcgc cgaccgcgat gggctgtggc caatagcggc 1200 tgctcagcag ggcgcgccga gagcagcggc cgggaagggg cggtgcggga ggcggggtgt 1260 ggggcggtag tgtgggccct gttcctgccc gcgcggtgtt ccgcattctg caagcctccg 1320 gagcgcacgt ccgtctcaag cttccttctt ctttttccta gaagctcaga ataaacgctc 1380 aactttggcc gccacc 1396 <210> 831 <211> 2304 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 831 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaagt taaatgagaa acctgtgtgt tcctttgggg 780 cggggctgac gtcgggaggt ggcctccacg ggaagggaca cccggatctc gacacagcct 840 tggcagtgga gtcaggaagg gtaggacaga ttctggacgc cctcttggcc agtcctcacc 900 gccccacccc cgatggagcc gagagtaatt catacaaaag gagggatcgc cttcgcccct 960 gggaatccca gggaccgtcg ctaaattctg gccggcctcc cagcccggaa ccgctgtgcc 1020 cgcccagcgc ggcgggagga gcctgcgcct agggcggatc gcgggtcggc gggagagcac 1080 aagcccacag tccccggcgg tgggggaggg gcgcgctgag cgggggcccg ggagccagcg 1140 cggggcaaac tgggaaagtg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg 1200 agaacggtat aaaagtgcgg tagtcgcgtt ggacgttctt tttcgcaacg ggtttgccgt 1260 cagaacgcag gtgagtggcg ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg 1320 ggtcggaccg ccgtgcgggt gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga 1380 tggcgggctg tgcgggaggg cgaggggggg aggcctggcg gcggccccgg agcctcgcct 1440 cgtgtcgggc gtgaggccta gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct 1500 ttgctgtctg cccggctgcc ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg 1560 cgtggagctg gctggtaggg agccccgtag tccgcatgtc gggcagggag agcggcagca 1620 gtcggggggg ggaccgggcc cgcccgtccc gcagcacatg tccgacgccg cctggacggg 1680 tagcggcctg tgtcctgata aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg 1740 gccccgggtc ccggcccggt ctggccagta ccccgtagtg gcttagctcc gaggagggcg 1800 agcccgcccg cccggcacca gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag 1860 caaggagctc aaaatggagg acgcggcagc ccggcggagc ggggcgggtg agtcacccac 1920 acaaaggaag agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc 1980 ggccgcactt cagtcacccc gggcgctctt tcggagcacc gctggcctcc gctgggggag 2040 gggatctgtc taatggcgtt ggagtttgct cacatttggt gggtggagac tgtagccagg 2100 ccagcctggc catggaagta attcttggaa tttgcccatt ttgagtttgg agcgaagctg 2160 attgacaaag ctgcttagcc gttcaaaggt attcttcgaa cttttttttt aaggtgttgt 2220 gaaaaccacc gctaattcaa atccaacagc ttgcttgttc tttttgcaga agctcagaat 2280 aaacgctcaa ctttggccgc cacc 2304 <210> 832 <211> 2190 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 832 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aacctctccc ggccagagga gcaaggtatg cgggaggcga 720 ccaggaggat agcggggctg acgtcgggag gtggcctccg tgggaaggac acccggatct 780 tgacacagcc ttggcagcgg agtcaggaag agtaggggta ggttctggac gccctcttgg 840 ccagctcatc gccgccccac cctctgctgg agcacagagt aattcataca aaaggaggga 900 tcgccttcgc aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct 960 gtagccgccc cacgacagcg cgaggagcat gcgcccaggg ctgagcgcgg gtagatcaga 1020 gcacacaagc tcacagtccc cggcggtggg gggaggggcg cgctgagcgg gggccaggga 1080 gctggcgcgg ggcaaactgg gaaagtggtg tcgtgtgctg gctccgccct cttcccgagg 1140 gtgggggaga acggtatata agtgcggtag tcgccttgga cgttcttttt cgcaacgggt 1200 ttgccgtcag aacgcaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc 1260 ctgctctgag cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat 1320 tcccacttcg agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt 1380 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg 1440 gccgcactat gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa 1500 caaagggagg gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat 1560 ggaagggcag gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc 1620 tggatggggc gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg 1680 ccatgtggcc ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc 1740 aacaagggtg aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc 1800 ggggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt 1860 gagtcaccca cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc 1920 cgtggtctat cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg 1980 ggggagggga tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg 2040 ccagcctggc gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa 2100 ttctcaagcc tcttagcggt tcaaaggtat tttctaaacc cgtttccagg tgttgtgaaa 2160 gccaccgcta attcaaagca agccgccacc 2190 <210> 833 <211> 1750 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 833 cttgctcacc tcgagtacga tagccggcta atcagccata ccacatttgt agaggtttta 60 cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt 120 gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca 180 aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc 240 aatgtatctt atcatgtctg gtattcggac ggtgacgata tttgaaaata tggcatattg 300 aaaatgtcgc cgatgtgagt ttctgtgtaa ctgatatcgc catttttcca aaagtgattt 360 ttgggcatac gcgatatctg gcgatagcgc ttatatcgtt tacgggggat ggcgatagac 420 gactttggtg acttgggcga ttctgtgtgt cgcaaatatc gcagtttcga tataggtgac 480 agacgatatg aggctatatc gccgatagag gcgacatcaa gctggcacat ggccaatgca 540 tatcgatcta tacattgaat caatattggc cattagccat attattcatt ggttatatag 600 cataaatcaa tattggctat tggccattgc atacgttgta tccatatcat aatatgtaca 660 tttatattgg ctcatgtcca acattaccgc catgttgaca ttgattattg actagttatt 720 aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat 780 aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa 840 taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg 900 agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc 960 cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct 1020 tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga 1080 tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa 1140 gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc 1200 caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg 1260 aggtctatat aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac 1320 gctgttttga cctccataga agataccggg accgatccag cctccgcggc cgggaacggt 1380 gcattggaac gcggattccc cgtgccaaga gtgaccctgg cagaactcgg taagtctgtt 1440 gacatgtatg tgatgtatac taacctgcat gggacgtgga tttacttgtg tatgtcagat 1500 agagtaaaga ttaactcttg catgtgagcg gggcatcgag atagcgataa atgagtcagg 1560 aggacggagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca 1620 acgtgctggt tattgtgctg tctcatcatt ttggcaaaga atttcaccgt ccttgacacg 1680 aagtttgctc gaagcttcct tcttcttttt cctagaagct cagaataaac gctcaacttt 1740 ggccgccacc 1750 <210> 834 <211> 1852 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 834 cttgctcacc tcgagtacga tagccggcta atcagccatg gctaataaag gaaatttatt 60 ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg 120 gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat 180 atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc 240 cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata 300 ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta 360 gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg 420 agatctattc ggacggtgac gatatttgaa aatatggcat attgaaaatg tcgccgatgt 480 gagtttctgt gtaactgata tcgccatttt tccaaaagtg atttttgggc atacgcgata 540 tctggcgata gcgcttatat cgtttacggg ggatggcgat agacgacttt ggtgacttgg 600 gcgattctgt gtgtcgcaaa tatcgcagtt tcgatatagg tgacagacga tatgaggcta 660 tatcgccgat agaggcgaca tcaagctggc acatggccaa tgcatatcga tctatacatt 720 gaatcaatat tggccattag ccatattatt cattggttat atagcataaa tcaatattgg 780 ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg 840 tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac 900 ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg 960 cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc 1020 catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac 1080 tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa 1140 tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac 1200 ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta 1260 catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga 1320 cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa 1380 ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag 1440 agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca 1500 tagaagatac cgggaccgat ccagcctccg cggccgggaa cggtgcattg gaacgcggat 1560 tccccgtgcc aagagtgacc ctggcagaac tcggtaagtc tgttgacatg tatgtgatgt 1620 atactaacct gcatgggacg tggatttact tgtgtatgtc agatagagta aagattaact 1680 cttgcatgtg agcggggcat cgagatagcg ataaatgagt caggaggacg gagcctctgc 1740 taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc tggtagcttc 1800 cttcttcttt ttcctagaag ctcagaataa acgctcaact ttggccgcca cc 1852 <210> 835 <211> 1860 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 835 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaattcgt ttatcggcca ccgaggccaa gatctggccg 720 ccaattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc 780 catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca 840 acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga 900 ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc 960 aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct 1020 ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat 1080 tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc 1140 ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt 1200 ggcaccaaaa tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa 1260 tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc 1320 agatcctcac tctcttccgc atcgctgtct gcgagggcca gctgttgggc tcgcggttga 1380 ggacaaactc ttcgcggtct ttccagtact cttggatcgg aaacccgtcg gcctccgaac 1440 ggtactccgc caccgaggga cctgagcgag tccgcatcga ccggatcgga aaacctctcg 1500 agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc gggcggcagc 1560 gggtggcggt cggggttgtt tctggcggag gtgctgctga tgatgtaatt aaagtaggcg 1620 gtcttgagac ggcggatggt cgaggtgagg tgtggcaggc ttgagatcca gctgttgggg 1680 tgagtactcc ctctcaaaag cgggcattac ttctgcgcta agattgtcag tttccaaaaa 1740 cgaggaggat ttgatattca cctggcccga tctggccata cacttgagtg acaatgacat 1800 ccactttgcc tttctctcca caggtgtcca ctcccaggtc caagtttaaa cgccgccacc 1860 <210> 836 <211> 1692 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 836 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaaaaatcg 660 ataatatatg gtagggttca tagccagagt aacctttttt tttaattttt attttatttt 720 atttttgagt cgggcgcgcc aaaatgaagt gaagttccta tactttctag aattgattat 780 tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt 840 tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc 900 cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac 960 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 1020 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc 1080 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 1140 ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac 1200 ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc 1260 aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc 1320 gtgtacggtg ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcgcctgga 1380 gaggccatcc acgctgtttt gacctccata gtggacaccg ggaccgatcc agcctccgcg 1440 gccgggaacg gtgcattgga acgcggattc cccgtgccaa gagtgacgta agtaccgcct 1500 atagagtcta taggcccacc cccttggctt cttatgcgta agtttctgtt tccatttcct 1560 ctcttgtgac acatttcatg actctgcatt tacataaccc ctgactcatg gtcttcccac 1620 tcttgttctc tcagagcttc cttcttcttt ttcctagaag ctcagaataa acgctcaact 1680 ttggccgcca cc 1692 <210> 837 <211> 1790 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 837 cttgctcacc tcgagtacga tagccggcta atcagccatg gctaataaag gaaatttatt 60 ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg 120 gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat 180 atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc 240 cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata 300 ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta 360 gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg 420 agatctattc ggacggtgac gatatttgaa aatatggcat attgaaaatg tcgccgatgt 480 gagtttctgt gtaactgata tcgccatttt tccaaaagtg atttttgggc atacgcgata 540 tctggcgata gcgcttatat cgtttacggg ggatggcgat agacgacttt ggtgacttgg 600 gcgattctgt gtgtcgcaaa tatcgcagtt tcgatatagg tgacagacga tatgaggcta 660 tatcgccgat agaggcgaca tcaagctggc acatggccaa tgcatatcga tctatacatt 720 gaatcaatat tggccattag ccatattatt cattggttat atagcataaa tcaatattgg 780 ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg 840 tccaacatta ccgccatgtt gacgccaaga tctggccgcc atatactgag tcattaggga 900 ctttccaatg ggttttgccc agtacataag gtcaataggg gtgaatcaac aggaaagtcc 960 cattggagcc aagtacactg agtcaatagg gactttccat tgggttttgc ccagtacaaa 1020 aggtcaatag ggggtgagtc aatgggtttt tcccattatt ggcacgtaca taaggtcaat 1080 aggggtgagt cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat 1140 tgacgtcaat gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag 1200 ctgattaatg ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca 1260 gccaaaacgt aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat 1320 tggctgagct gcgttctacg tgggtataag aggcgcgacc agcgtcggta gggaccggtt 1380 tgccgccaga acacagtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 1440 gaagataccg ggaccgatcc agcctccgcg gccgggaacg gtgcattgga acgcggattc 1500 cccgtgccaa gagtgaccct ggcagaactc ggtaagtctg ttgacatgta tgtgatgtat 1560 actaacctgc atgggacgtg gatttacttg tgtatgtcag atagagtaaa gattaactct 1620 tgcatgtgag cggggcatcg agatagcgat aaatgagtca ggaggacgga gcctctgcta 1680 accatgttca tgccttcttc tttttcctac agctcctggg caacgtgctg gtagcttcct 1740 tcttcttttt cctagaagct cagaataaac gctcaacttt ggccgccacc 1790 <210> 838 <211> 1798 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 838 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaattcgt ttatcggcca ccgaggccaa gatctggccg 720 ccagccaaga tctggccgcc atatactgag tcattaggga ctttccaatg ggttttgccc 780 agtacataag gtcaataggg gtgaatcaac aggaaagtcc cattggagcc aagtacactg 840 agtcaatagg gactttccat tgggttttgc ccagtacaaa aggtcaatag ggggtgagtc 900 aatgggtttt tcccattatt ggcacgtaca taaggtcaat aggggtgagt cattgggttt 960 ttccagccaa tttataaaac gccatgtact ttcccaccat tgacgtcaat gggctattga 1020 aactaatgca acgtgacctt taaacggtac tttcccatag ctgattaatg ggaaagtacc 1080 gttctcgagc caatacacgt caatgggaag tgaaagggca gccaaaacgt aacaccgccc 1140 cggttttccc ctggaaattc catattggca cgcattctat tggctgagct gcgttctacg 1200 tgggtataag aggcgcgacc agcgtcggta gggaccggtt tgccgccaga acacagtcag 1260 atcctcactc tcttccgcat cgctgtctgc gagggccagc tgttgggctc gcggttgagg 1320 acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc ctccgaacgg 1380 tactccgcca ccgagggacc tgagcgagtc cgcatcgacc ggatcggaaa acctctcgag 1440 aaaggcgtct aaccagtcac agtcgcaagg taggctgagc accgtggcgg gcggcagcgg 1500 gtggcggtcg gggttgtttc tggcggaggt gctgctgatg atgtaattaa agtaggcggt 1560 cttgagacgg cggatggtcg aggtgaggtg tggcaggctt gagatccagc tgttggggtg 1620 agtactccct ctcaaaagcg ggcattactt ctgcgctaag attgtcagtt tccaaaaacg 1680 aggaggattt gatattcacc tggcccgatc tggccataca cttgagtgac aatgacatcc 1740 actttgcctt tctctccaca ggtgtccact cccaggtcca agtttaaacg ccgccacc 1798 <210> 839 <211> 1630 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 839 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaaaaatcg 660 ataatatatg gtagggttca tagccagagt aacctttttt tttaattttt attttatttt 720 atttttgagt cgggcgcgcc aaaatgaagt gaagttccta tactttctag agccaagatc 780 tggccgccat atactgagtc attagggact ttccaatggg ttttgcccag tacataaggt 840 caataggggt gaatcaacag gaaagtccca ttggagccaa gtacactgag tcaataggga 900 ctttccattg ggttttgccc agtacaaaag gtcaataggg ggtgagtcaa tgggtttttc 960 ccattattgg cacgtacata aggtcaatag gggtgagtca ttgggttttt ccagccaatt 1020 tataaaacgc catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac 1080 gtgaccttta aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca 1140 atacacgtca atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttcccct 1200 ggaaattcca tattggcacg cattctattg gctgagctgc gttctacgtg ggtataagag 1260 gcgcgaccag cgtcggtagg gaccggtttg ccgccagaac acagtcagat cgcctggaga 1320 ggccatccac gctgttttga cctccatagt ggacaccggg accgatccag cctccgcggc 1380 cgggaacggt gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat 1440 agagtctata ggcccacccc cttggcttct tatgcgtaag tttctgtttc catttcctct 1500 cttgtgacac atttcatgac tctgcattta cataacccct gactcatggt cttcccactc 1560 ttgttctctc agagcttcct tcttcttttt cctagaagct cagaataaac gctcaacttt 1620 ggccgccacc 1630 <210> 840 <211> 3898 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 840 ggggcttgct cacctcgagt acgatagccg gctaatcagc cataccacat ttgtagaggt 60 tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc 120 aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat 180 cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact 240 catcaatgta tcttatcatg tctggtattc ggacggtgaa ctgggccttt cgcccgggct 300 aattatgggg tgtcgccctt cgctgaaggc cctccgcgcc tacagctcaa gccacatccg 360 aagggggagg gagccgggag ctgcgcgcgg ggccgccggg gggaggggtg gcaccgccca 420 cgccgggcgg ccacgaaggg cggggcagcg ggcgcgcgcc cggcgggggg aggggccgcg 480 cgccgcgccc gctgggaatt ggggccctag ggggagggcg gaggcgccga cgaccgcggc 540 acttaccgtt cgcggcgtgg cgcccggtgg tccccaaggg gagggaaggg ggaggcgggg 600 cgaggacagt gaccggagtc tcctcagcgg tggcttttct gcttggcagc ctcagcggct 660 ggcgccaaaa ccggactccg cccacttcct cgcccctgcg gtgcgagggt gtggaatcct 720 ccagacgctg ggggaggggg agttgggagc ttaaaaacta gtaccccttt gggaccactt 780 tcagcagcga actctcctgt acaccagggg tcagttccac agacgcgggc caggggtggg 840 tcattgcggc gtgaacaata atttgactag aagttgattc gggtgtttcc ggaaggggcc 900 gagtcaatcc gccgagttgg ggcacggaaa acaaaaaggg aaggctacta agatttttct 960 ggcgggggtt atcattggcg taactgcagg gaccacctcc cgggttgagg gggctggatc 1020 tccaggctgc ggattaagcc cctcccgtcg gcgttaattt caaactgcgc gaccgtttct 1080 cacctgcctt gcgccaaggc agggggcggg accctattcc aagaggtagt aactagcagg 1140 actctagcct tccgcaattc attgagcgca tttacggaag taacgtcggg tactgtctct 1200 ggccgcaagg gtgggaggag tacgcatttg gcgtaaggtg gggcgtagag ccttcccgcc 1260 attggcggcg gatagggcgt ttacgcgacg gcctgacgta gcggatgacg cgttagtggg 1320 ggggaaggtt ctagaaaagc ggcggcagcg gctctagcgg cagtagcagc agcgccgggt 1380 cccgtgcgga ggtgctcctc gcagagttgt ttctcgagca gcggcagttc tcactacagc 1440 gccaggacga gtccggttcg tgttcgtccg cggagatcga tctctctcat ctcgctcggc 1500 tgcgggaaat cgggctgaag cgactgagtc cgcgatggag gtaacgggtt tgaaatcaat 1560 gagttattga aaagggcatg gcgaggccgt tggcgcctca gtggaagtcg gccagccgcc 1620 tccgtgggag agaggcagga aatcggacca attcagtagc agtggggctt aaggtttatg 1680 aacggggtct tgagcggagg cctgagcgta caaacagctt ccccaccctc agcctcccgg 1740 cgccatttcc cttcactggg ggtgggggat ggggagcttt cacatggcgg acgctgcccc 1800 gctggggtga aagtggggcg cggaggcggg aattcttatt ccctttctaa agcacgctgc 1860 ttcgggggcc acggcgactc ctcggcgtcc gatatttgaa aatatggcat attgaaaatg 1920 tcgccgatgt gagtttctgt gtaactgata tcgccatttt tccaaaagtg atttttgggc 1980 atacgcgata tctggcgata gcgcttatat cgtttacggg ggatggcgat agacgacttt 2040 ggtgacttgg gcgattctgt gtgtcgcaaa tatcgcagtt tcgatatagg tgacagacga 2100 tatgaggcta tatcgccgat agaggcgaca tcaagctggc acatggccaa tgcatatcga 2160 tctatacatt gaatcaatat tggccattag ccatattatt cattggttat atagcataaa 2220 tcaatattgg ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata 2280 ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt 2340 aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta 2400 cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga 2460 cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt 2520 tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta 2580 ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg 2640 actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt 2700 tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc 2760 accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat 2820 gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct 2880 atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt 2940 ttgacctcca tagaagatac cgggaccgat ccagcctccg cggccgggaa cggtgcattg 3000 gaacgcggat tccccgtgcc aagagtgacg taagtaccgc ctatagagtc tataggccca 3060 cccccttggc ttcttatgca tgctatactg tttttggctt ggggtctata cacccccgct 3120 tcctcatgtt ataggtgatg gtatagctta gcctataggt gtgggttatt gaccattatt 3180 gaccactccc ctattggtga cgatactttc cattactaat ccataacatg gctctttgcc 3240 acaactctct ttattggcta tatgccaata cactgtcctt cagagactga cacggactct 3300 gtatttttac aggatgggtt ctcatttatt atttacaaat tcacatatac aacaccaccg 3360 tccccagtgc ccgcagtttt tattaaacat aacgtgggat ctccacgcga atctcgggta 3420 cgtgttccgg acatgggttc ttctccggta gcggcggagc ttctacatcc gagccctgct 3480 cccatgcctc cagcgactca tggtcgctcg gcagctcctt gctcctaaca gtggaggcca 3540 gacttaggca cagcacgatg cccaccacca ccagtgtgcc gcacaaggcc gtggcggtag 3600 ggtatgtgtc tgaaaatgag ctcggggagc gggcttgcac cgctgacgca tttgaaagac 3660 ttaaggcagc ggcagaagaa gatgcaggca gctgagttgt tgtgttctga taagagtcag 3720 aggtaactcc cgttgcggtg ctgttaacgg tggagggcag tgtagtctga gcagtactcg 3780 ttgctgccgc gcgcgccacc agacataata gctgacagac taacagactg ttcctttcca 3840 tgggtctttt ctgcagtcac cgtccttgac acgaagtttg ctcgagccgc caccaaaa 3898 <210> 841 <211> 2505 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 841 ccgcctagga cgggggaggc taactgaaac acggaaggag acaataccgg aaggaacccg 60 cgctatgacg gcaataaaaa gacagaataa aacgcacggg tgttgggtcg tttgttcata 120 aacgcggggt tcggtcccag ggctggcact ctgtcgatac cccaccgagt ccccattggg 180 gccaatacgc ccgcgtttct tccttttccc caccccaccc cccaagttcg ggtgaaggcc 240 cagggctcgc agccaacgtc ggggcggcag gccctgccat agaaatcgat aatatatggt 300 agggttcata gccagagtaa cctttttttt taatttttat tttattttat ttttgagtcg 360 ggcgcgccaa aatgaagtga agttcctata ctttctagag cgagctcacg gggacagccc 420 ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc agcagcgagc 480 cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg 540 ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg cttctcgctg 600 ctctttgagc ctgcagacac ctggggggat acggggaaaa agctttaggc tgaaagagag 660 atttagaatg acaggcgagc tcacggggac agcccccccc caaagccccc agggatgtaa 720 ttacgtccct cccccgctag ggggcagcag cgagccgccc ggggctccgc tccggtccgg 780 cgctcccccc gcatccccga gccggcagcg tgcggggaca gcccgggcac ggggaaggtg 840 gcacgggatc gctttcctct gaacgcttct cgctgctctt tgagcctgca gacacctggg 900 gggatacggg gaaaaagctt gaaacttgat ctgtcgccgc aattcaagct tcgtgaggct 960 ccggtgcccg tcagtgacct gctatactct ggagacgcct ctcccggcca gaggagcaag 1020 gtatgcggga ggcgaccagg aggatagcgg ggctgacgtc gggaggtggc ctccgtggga 1080 aggacacccg gatcttgaca cagccttggc agcggagtca ggaagagtag gggtaggttc 1140 tggacgccct cttggccagc tcatcgccgc cccaccctct gctggagcac agagtaattc 1200 atacaaaagg agggatcgcc ttcgcaaggg gagagcccag ggaccgtccc taaattctca 1260 cagacccaaa tccctgtagc cgccccacga cagcgcgagg agcatgcgcc cagggctgag 1320 cgcgggtaga tcagagcaca caagctcaca gtccccggcg gtggggggag gggcgcgctg 1380 agcgggggcc agggagctgg cgcggggcaa actgggaaag tggtgtcgtg tgctggctcc 1440 gccctcttcc cgagggtggg ggagaacggt atataagtgc ggtagtcgcc ttggacgttc 1500 tttttcgcaa cgggtttgcc gtcagaacgc aggtgagtgg cgggtgtggc ttccgcgggc 1560 cccggagctg gagccctgct ctgagcgggc cgggctgata tgcgagtgtc gtccgcaggg 1620 tttagctgtg agcattccca cttcgagtgg cgggcggtgc gggggtgaga gtgcgaggcc 1680 tagcggcaac cccgtagcct cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgccg 1740 ccgcgtgcca ctccggccgc actatgcgtt ttttgtcctt gctgccctcg attgccttcc 1800 agcagcatgg gctaacaaag ggagggtgtg gggctcactc ttaaggagcc catgaagctt 1860 acgttggata ggaatggaag ggcaggaggg gcgactgggg cccgcccgcc ttcggagcac 1920 atgtccgacg ccacctggat ggggcgaggc ctgtggcttt ccgaagcaat cgggcgtgag 1980 tttagcctac ctgggccatg tggccctagc actgggcacg gtctggcctg gcggtgccgc 2040 gttcccttgc ctcccaacaa gggtgaggcc gtcccgcccg gcaccagttg cttgcgcgga 2100 aagatggccg ctcccggggc cctgttgcaa ggagctcaaa atggaggacg cggcagcccg 2160 gtggagcggg cgggtgagtc acccacacaa aggaagaggg ccttgcccct cgccggccgc 2220 tgcttcctgt gaccccgtgg tctatcggcc gcatagtcac ctcgggcttc tcttgagcac 2280 cgctcgtcgc ggcgggggga ggggatctaa tggcgttgga gtttgttcac atttggtggg 2340 tggagactag tcaggccagc ctggcgctgg aagtcattct tggaatttgc ccctttgagt 2400 ttggagcgag gctaattctc aagcctctta gcggttcaaa ggtattttct aaacccgttt 2460 ccaggtgttg tgaaagccac cgctaattca aagcaagccg ccacc 2505 <210> 842 <211> 3252 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 842 ccgcctagga caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta 60 actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta 120 ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt 180 atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg 240 caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt 300 tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag 360 gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc 420 cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc 480 cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc 540 ttccgcctct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc 600 ccatgtatct ttttcacctg tgccttgttt ttgcctgtgt tccatgtcct acttttcaag 660 cctccaagct gtgccttgga tggctttggg gcatggacat agatccctat aaagaatttg 720 gttcatctta tcagttgttg aattttcttc ctttggacgg gggaggctaa ctgaaacacg 780 gaaggagaca ataccggaag gaacccgcgc tatgacggca ataaaaagac agaataaaac 840 gcacgggtgt tgggtcgttt gttcataaac gcggggttcg gtcccagggc tggcactctg 900 tcgatacccc accgagtccc cattggggcc aatacgcccg cgtttcttcc ttttccccac 960 cccacccccc aagttcgggt gaaggcccag ggctcgcagc caacgtcggg gcggcaggcc 1020 ctgccataga aatcgataat atatggtagg gttcatagcc agagtaacct ttttttttaa 1080 tttttatttt attttatttt tgagtcgggc gcgccaaaat gaagtgaagt tcctatactt 1140 tctagagcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 1200 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 1260 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 1320 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 1380 gggaaaaagc tttaggctga aagagagatt tagaatgaca ggcgagctca cggggacagc 1440 ccccccccaa agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga 1500 gccgcccggg gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc 1560 ggggacagcc cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc 1620 tgctctttga gcctgcagac acctgggggg atacggggaa aaagcttgaa acttgatctg 1680 tcgccgcaat tcaagcttcg tgaggctccg gtgcccgtca gtgacctgct atactctgga 1740 gacgcctctc ccggccagag gagcaaggta tgcgggaggc gaccaggagg atagcggggc 1800 tgacgtcggg aggtggcctc cgtgggaagg acacccggat cttgacacag ccttggcagc 1860 ggagtcagga agagtagggg taggttctgg acgccctctt ggccagctca tcgccgcccc 1920 accctctgct ggagcacaga gtaattcata caaaaggagg gatcgccttc gcaaggggag 1980 agcccaggga ccgtccctaa attctcacag acccaaatcc ctgtagccgc cccacgacag 2040 cgcgaggagc atgcgcccag ggctgagcgc gggtagatca gagcacacaa gctcacagtc 2100 cccggcggtg gggggagggg cgcgctgagc gggggccagg gagctggcgc ggggcaaact 2160 gggaaagtgg tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata 2220 taagtgcggt agtcgccttg gacgttcttt ttcgcaacgg gtttgccgtc agaacgcagg 2280 tgagtggcgg gtgtggcttc cgcgggcccc ggagctggag ccctgctctg agcgggccgg 2340 gctgatatgc gagtgtcgtc cgcagggttt agctgtgagc attcccactt cgagtggcgg 2400 gcggtgcggg ggtgagagtg cgaggcctag cggcaacccc gtagcctcgc ctcgtgtccg 2460 gcttgaggcc tagcgtggtg tccgccgccg cgtgccactc cggccgcact atgcgttttt 2520 tgtccttgct gccctcgatt gccttccagc agcatgggct aacaaaggga gggtgtgggg 2580 ctcactctta aggagcccat gaagcttacg ttggatagga atggaagggc aggaggggcg 2640 actggggccc gcccgccttc ggagcacatg tccgacgcca cctggatggg gcgaggcctg 2700 tggctttccg aagcaatcgg gcgtgagttt agcctacctg ggccatgtgg ccctagcact 2760 gggcacggtc tggcctggcg gtgccgcgtt cccttgcctc ccaacaaggg tgaggccgtc 2820 ccgcccggca ccagttgctt gcgcggaaag atggccgctc ccggggccct gttgcaagga 2880 gctcaaaatg gaggacgcgg cagcccggtg gagcgggcgg gtgagtcacc cacacaaagg 2940 aagagggcct tgcccctcgc cggccgctgc ttcctgtgac cccgtggtct atcggccgca 3000 tagtcacctc gggcttctct tgagcaccgc tcgtcgcggc ggggggaggg gatctaatgg 3060 cgttggagtt tgttcacatt tggtgggtgg agactagtca ggccagcctg gcgctggaag 3120 tcattcttgg aatttgcccc tttgagtttg gagcgaggct aattctcaag cctcttagcg 3180 gttcaaaggt attttctaaa cccgtttcca ggtgttgtga aagccaccgc taattcaaag 3240 caagccgcca cc 3252 <210> 843 <211> 3231 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 843 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcagctggac 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt atacatcgtt 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg 780 aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg 840 ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagtcccc 900 attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg 960 aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagaa atcgataata 1020 tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta ttttattttt 1080 gagtcgggcg cgccaaaatg aagtgaagtt cctatacttt ctagagcgag ctcacgggga 1140 cagccccccc ccaaagcccc cagggatgta attacgtccc tcccccgcta gggggcagca 1200 gcgagccgcc cggggctccg ctccggtccg gcgctccccc cgcatccccg agccggcagc 1260 gtgcggggac agcccgggca cggggaaggt ggcacgggat cgctttcctc tgaacgcttc 1320 tcgctgctct ttgagcctgc agacacctgg ggggatacgg ggaaaaagct ttaggctgaa 1380 agagagattt agaatgacag gcgagctcac ggggacagcc cccccccaaa gcccccaggg 1440 atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg 1500 gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg 1560 aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca 1620 cctgggggga tacggggaaa aagcttgaaa cttgatctgt cgccgcaatt caagcttcgt 1680 gaggctccgg tgcccgtcag tgacctgcta tactctggag acgcctctcc cggccagagg 1740 agcaaggtat gcgggaggcg accaggagga tagcggggct gacgtcggga ggtggcctcc 1800 gtgggaagga cacccggatc ttgacacagc cttggcagcg gagtcaggaa gagtaggggt 1860 aggttctgga cgccctcttg gccagctcat cgccgcccca ccctctgctg gagcacagag 1920 taattcatac aaaaggaggg atcgccttcg caaggggaga gcccagggac cgtccctaaa 1980 ttctcacaga cccaaatccc tgtagccgcc ccacgacagc gcgaggagca tgcgcccagg 2040 gctgagcgcg ggtagatcag agcacacaag ctcacagtcc ccggcggtgg ggggaggggc 2100 gcgctgagcg ggggccaggg agctggcgcg gggcaaactg ggaaagtggt gtcgtgtgct 2160 ggctccgccc tcttcccgag ggtgggggag aacggtatat aagtgcggta gtcgccttgg 2220 acgttctttt tcgcaacggg tttgccgtca gaacgcaggt gagtggcggg tgtggcttcc 2280 gcgggccccg gagctggagc cctgctctga gcgggccggg ctgatatgcg agtgtcgtcc 2340 gcagggttta gctgtgagca ttcccacttc gagtggcggg cggtgcgggg gtgagagtgc 2400 gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct agcgtggtgt 2460 ccgccgccgc gtgccactcc ggccgcacta tgcgtttttt gtccttgctg ccctcgattg 2520 ccttccagca gcatgggcta acaaagggag ggtgtggggc tcactcttaa ggagcccatg 2580 aagcttacgt tggataggaa tggaagggca ggaggggcga ctggggcccg cccgccttcg 2640 gagcacatgt ccgacgccac ctggatgggg cgaggcctgt ggctttccga agcaatcggg 2700 cgtgagttta gcctacctgg gccatgtggc cctagcactg ggcacggtct ggcctggcgg 2760 tgccgcgttc ccttgcctcc caacaagggt gaggccgtcc cgcccggcac cagttgcttg 2820 cgcggaaaga tggccgctcc cggggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2880 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctt gcccctcgcc 2940 ggccgctgct tcctgtgacc ccgtggtcta tcggccgcat agtcacctcg ggcttctctt 3000 gagcaccgct cgtcgcggcg gggggagggg atctaatggc gttggagttt gttcacattt 3060 ggtgggtgga gactagtcag gccagcctgg cgctggaagt cattcttgga atttgcccct 3120 ttgagtttgg agcgaggcta attctcaagc ctcttagcgg ttcaaaggta ttttctaaac 3180 ccgtttccag gtgttgtgaa agccaccgct aattcaaagc aagccgccac c 3231 <210> 844 <211> 3106 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 844 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca actcccactg gttggggcat ttgcaccacc tgtcaactca tttccggtac 300 tttcggtttc tcacttccga ttgctaccgc ggagcttata gccgcctgcc ttgctcgctg 360 ctggacagga gctcggttgt tgggcactga taactccgtg gtcctctccg gtaagctaac 420 ttcgtttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcgtctgc cccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgcct gtgggggagg ctaactgaaa cacggaagga gacaataccg gaaggaaccc 660 gcgctatgac ggcaataaaa agacagaata aaacgcacgg gtgttgggtc gtttgttcat 720 aaacgcgggg ttcggtccca gggctggcac tctgtcgata ccccaccgag tccccattgg 780 ggccaatacg cccgcgtttc ttccttttcc ccaccccacc ccccaagttc gggtgaaggc 840 ccagggctcg cagccaacgt cggggcggca ggccctgcca tagaaatcga taatatatgg 900 tagggttcat agccagagta accttttttt ttaattttta ttttatttta tttttgagtc 960 gggcgcgcca aaatgaagtg aagttcctat actttctaga gcgagctcac ggggacagcc 1020 cccccccaaa gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag 1080 ccgcccgggg ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg 1140 gggacagccc gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct 1200 gctctttgag cctgcagaca cctgggggga tacggggaaa aagctttagg ctgaaagaga 1260 gatttagaat gacaggcgag ctcacgggga cagccccccc ccaaagcccc cagggatgta 1320 attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg 1380 gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt 1440 ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg 1500 ggggatacgg ggaaaaagct tgaaacttga tctgtcgccg caattcaagc ttcgtgaggc 1560 tccggtgccc gtcagtgacc tgctatactc tggagacgcc tctcccggcc agaggagcaa 1620 ggtatgcggg aggcgaccag gaggatagcg gggctgacgt cgggaggtgg cctccgtggg 1680 aaggacaccc ggatcttgac acagccttgg cagcggagtc aggaagagta ggggtaggtt 1740 ctggacgccc tcttggccag ctcatcgccg ccccaccctc tgctggagca cagagtaatt 1800 catacaaaag gagggatcgc cttcgcaagg ggagagccca gggaccgtcc ctaaattctc 1860 acagacccaa atccctgtag ccgccccacg acagcgcgag gagcatgcgc ccagggctga 1920 gcgcgggtag atcagagcac acaagctcac agtccccggc ggtgggggga ggggcgcgct 1980 gagcgggggc cagggagctg gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc 2040 cgccctcttc ccgagggtgg gggagaacgg tatataagtg cggtagtcgc cttggacgtt 2100 ctttttcgca acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cttccgcggg 2160 ccccggagct ggagccctgc tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg 2220 gtttagctgt gagcattccc acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc 2280 ctagcggcaa ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc 2340 gccgcgtgcc actccggccg cactatgcgt tttttgtcct tgctgccctc gattgccttc 2400 cagcagcatg ggctaacaaa gggagggtgt ggggctcact cttaaggagc ccatgaagct 2460 tacgttggat aggaatggaa gggcaggagg ggcgactggg gcccgcccgc cttcggagca 2520 catgtccgac gccacctgga tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga 2580 gtttagccta cctgggccat gtggccctag cactgggcac ggtctggcct ggcggtgccg 2640 cgttcccttg cctcccaaca agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg 2700 aaagatggcc gctcccgggg ccctgttgca aggagctcaa aatggaggac gcggcagccc 2760 ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gccttgcccc tcgccggccg 2820 ctgcttcctg tgaccccgtg gtctatcggc cgcatagtca cctcgggctt ctcttgagca 2880 ccgctcgtcg cggcgggggg aggggatcta atggcgttgg agtttgttca catttggtgg 2940 gtggagacta gtcaggccag cctggcgctg gaagtcattc ttggaatttg cccctttgag 3000 tttggagcga ggctaattct caagcctctt agcggttcaa aggtattttc taaacccgtt 3060 tccaggtgtt gtgaaagcca ccgctaattc aaagcaagcc gccacc 3106 <210> 845 <211> 3290 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 845 ccgcctagga ccaacatctt gagtcccttt atgccgctgt taccaatttt cttttgtctt 60 tgggtataca tttaaaccct aacaaaacaa aaagatgggg atattccctt aacttcatgg 120 gatatgtaat tgggagttgg ggcacatggc cacaggatca tattgtacaa aacttcaaac 180 tatgttttag aaaacttcct gttaatcaac ctctggatta caaaatttgt gaaagattga 240 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 300 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 360 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 420 tgtttgctga cgcaaccccc actggttggg gcatttgcac cacctatcaa ctcatttccc 480 cgacgggcgc ttttgccctg ccgatcgcca ccgcggacgt catcgccgcc tgccttgctc 540 gctgctggac aggagctcgg ctgttgggca ctgacaactc cgtggttctt tcgggcaaac 600 tgacttccta tccatggctg ctcgcctgtg ttgccaactg gattcttcgc gggacgtcct 660 tctgttacgt cccctccgcg gacaacccag cggaccttcc ttcccgggga cttctgccgg 720 ctctccgtcc tctgccgctt ctgcgttttc gtccggtcac caagcggata tccctgtggg 780 ccgcctcccc gcctgtgggg gaggctaact gaaacacgga aggagacaat accggaagga 840 acccgcgcta tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt 900 tcataaacgc ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca 960 ttggggccaa tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga 1020 aggcccaggg ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat 1080 atggtagggt tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg 1140 agtcgggcgc gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac 1200 agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag 1260 cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg 1320 tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct 1380 cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa 1440 gagagattta gaatgacagg cgagctcacg gggacagccc ccccccaaag cccccaggga 1500 tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg 1560 tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga 1620 aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac 1680 ctggggggat acggggaaaa agcttgaaac ttgatctgtc gccgcaattc aagcttcgtg 1740 aggctccggt gcccgtcagt gacctgctat actctggaga cgcctctccc ggccagagga 1800 gcaaggtatg cgggaggcga ccaggaggat agcggggctg acgtcgggag gtggcctccg 1860 tgggaaggac acccggatct tgacacagcc ttggcagcgg agtcaggaag agtaggggta 1920 ggttctggac gccctcttgg ccagctcatc gccgccccac cctctgctgg agcacagagt 1980 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 2040 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgcccaggg 2100 ctgagcgcgg gtagatcaga gcacacaagc tcacagtccc cggcggtggg gggaggggcg 2160 cgctgagcgg gggccaggga gctggcgcgg ggcaaactgg gaaagtggtg tcgtgtgctg 2220 gctccgccct cttcccgagg gtgggggaga acggtatata agtgcggtag tcgccttgga 2280 cgttcttttt cgcaacgggt ttgccgtcag aacgcaggtg agtggcgggt gtggcttccg 2340 cgggccccgg agctggagcc ctgctctgag cgggccgggc tgatatgcga gtgtcgtccg 2400 cagggtttag ctgtgagcat tcccacttcg agtggcgggc ggtgcggggg tgagagtgcg 2460 aggcctagcg gcaaccccgt agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc 2520 cgccgccgcg tgccactccg gccgcactat gcgttttttg tccttgctgc cctcgattgc 2580 cttccagcag catgggctaa caaagggagg gtgtggggct cactcttaag gagcccatga 2640 agcttacgtt ggataggaat ggaagggcag gaggggcgac tggggcccgc ccgccttcgg 2700 agcacatgtc cgacgccacc tggatggggc gaggcctgtg gctttccgaa gcaatcgggc 2760 gtgagtttag cctacctggg ccatgtggcc ctagcactgg gcacggtctg gcctggcggt 2820 gccgcgttcc cttgcctccc aacaagggtg aggccgtccc gcccggcacc agttgcttgc 2880 gcggaaagat ggccgctccc ggggccctgt tgcaaggagc tcaaaatgga ggacgcggca 2940 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggccttg cccctcgccg 3000 gccgctgctt cctgtgaccc cgtggtctat cggccgcata gtcacctcgg gcttctcttg 3060 agcaccgctc gtcgcggcgg ggggagggga tctaatggcg ttggagtttg ttcacatttg 3120 gtgggtggag actagtcagg ccagcctggc gctggaagtc attcttggaa tttgcccctt 3180 tgagtttgga gcgaggctaa ttctcaagcc tcttagcggt tcaaaggtat tttctaaacc 3240 cgtttccagg tgttgtgaaa gccaccgcta attcaaagca agccgccacc 3290 <210> 846 <211> 3226 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 846 ccgcctagga cttccactca acaaaccttt agattataaa atctgtgaaa ggttaacagg 60 cattctgaat tatgttgctc cttttactaa atgtggttat gctgctctcc ttcctttgta 120 tcaagctact tcgcgtacgg catttgtgtt ttcttctctc taccacagct ggttgctgtc 180 cctttatgct gagttgtggc ctgttgccag gcaacgtggc gtggtgtgct ctgtgtctga 240 cgcaaccccc actggttggg gcatttgcac cacctatcaa ctcatttccc cgacgggcgc 300 ttttgccctg ccgatcgcca ccgcggacgt catcgccgcc tgccttgctc gctgctggac 360 aggagctcgg ctgttgggca ctgacaactc cgtggttctt tcgggcaaac tgacttccta 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacctg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tggggggagg ctaactgaaa cacggaagga gacaataccg gaaggaaccc 780 gcgctatgac ggcaataaaa agacagaata aaacgcacgg gtgttgggtc gtttgttcat 840 aaacgcgggg ttcggtccca gggctggcac tctgtcgata ccccaccgag tccccattgg 900 ggccaatacg cccgcgtttc ttccttttcc ccaccccacc ccccaagttc gggtgaaggc 960 ccagggctcg cagccaacgt cggggcggca ggccctgcca tagaaatcga taatatatgg 1020 tagggttcat agccagagta accttttttt ttaattttta ttttatttta tttttgagtc 1080 gggcgcgcca aaatgaagtg aagttcctat actttctaga gcgagctcac ggggacagcc 1140 cccccccaaa gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag 1200 ccgcccgggg ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg 1260 gggacagccc gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct 1320 gctctttgag cctgcagaca cctgggggga tacggggaaa aagctttagg ctgaaagaga 1380 gatttagaat gacaggcgag ctcacgggga cagccccccc ccaaagcccc cagggatgta 1440 attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg 1500 gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt 1560 ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg 1620 ggggatacgg ggaaaaagct tgaaacttga tctgtcgccg caattcaagc ttcgtgaggc 1680 tccggtgccc gtcagtgacc tgctatactc tggagacgcc tctcccggcc agaggagcaa 1740 ggtatgcggg aggcgaccag gaggatagcg gggctgacgt cgggaggtgg cctccgtggg 1800 aaggacaccc ggatcttgac acagccttgg cagcggagtc aggaagagta ggggtaggtt 1860 ctggacgccc tcttggccag ctcatcgccg ccccaccctc tgctggagca cagagtaatt 1920 catacaaaag gagggatcgc cttcgcaagg ggagagccca gggaccgtcc ctaaattctc 1980 acagacccaa atccctgtag ccgccccacg acagcgcgag gagcatgcgc ccagggctga 2040 gcgcgggtag atcagagcac acaagctcac agtccccggc ggtgggggga ggggcgcgct 2100 gagcgggggc cagggagctg gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc 2160 cgccctcttc ccgagggtgg gggagaacgg tatataagtg cggtagtcgc cttggacgtt 2220 ctttttcgca acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cttccgcggg 2280 ccccggagct ggagccctgc tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg 2340 gtttagctgt gagcattccc acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc 2400 ctagcggcaa ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc 2460 gccgcgtgcc actccggccg cactatgcgt tttttgtcct tgctgccctc gattgccttc 2520 cagcagcatg ggctaacaaa gggagggtgt ggggctcact cttaaggagc ccatgaagct 2580 tacgttggat aggaatggaa gggcaggagg ggcgactggg gcccgcccgc cttcggagca 2640 catgtccgac gccacctgga tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga 2700 gtttagccta cctgggccat gtggccctag cactgggcac ggtctggcct ggcggtgccg 2760 cgttcccttg cctcccaaca agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg 2820 aaagatggcc gctcccgggg ccctgttgca aggagctcaa aatggaggac gcggcagccc 2880 ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gccttgcccc tcgccggccg 2940 ctgcttcctg tgaccccgtg gtctatcggc cgcatagtca cctcgggctt ctcttgagca 3000 ccgctcgtcg cggcgggggg aggggatcta atggcgttgg agtttgttca catttggtgg 3060 gtggagacta gtcaggccag cctggcgctg gaagtcattc ttggaatttg cccctttgag 3120 tttggagcga ggctaattct caagcctctt agcggttcaa aggtattttc taaacccgtt 3180 tccaggtgtt gtgaaagcca ccgctaattc aaagcaagcc gccacc 3226 <210> 847 <211> 3290 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 847 ccgcctagga cgagcatctt accgccattt attcccatat ttgctctgtt tttcttgatt 60 tgggcataca tttaaatgta gccaaaacta aatggtgggg acatcattta catttcatgg 120 gttatgttat tactggagca ggaattttac cccaagataa acatgtgcaa aaagtatcaa 180 catatttgaa atccattcct gtaaacaggc ctattgattg gaaagtttgt caacgaattg 240 tgggtctttt ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt 300 tatatgcatg tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc 360 tcagtaaaca gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag 420 tgtttgctga cgcaactccc actggttggg gcatttgcac cacctgtcaa ctcatttccg 480 gtactttcgg tttctcactt ccgattgcta ccgcggagct tatagccgcc tgccttgctc 540 gctgctggac aggagctcgg ttgttgggca ctgataactc cgtggtcctc tccggtaagc 600 taacttcgtt tccatggctg ctcgcctgtg ttgccaactg gattcttcgc gggacgtcgt 660 tctgctacgt cccttcggca gcgaatccgg cggaccttcc ttcccgaggc cttctgccgg 720 ctctgcatcc cgtgccgact ctccgcttcc gtccgcagct gagtcgcatc tccctttggg 780 ccgcctcccc gcctgtgggg gaggctaact gaaacacgga aggagacaat accggaagga 840 acccgcgcta tgacggcaat aaaaagacag aataaaacgc acgggtgttg ggtcgtttgt 900 tcataaacgc ggggttcggt cccagggctg gcactctgtc gataccccac cgagtcccca 960 ttggggccaa tacgcccgcg tttcttcctt ttccccaccc caccccccaa gttcgggtga 1020 aggcccaggg ctcgcagcca acgtcggggc ggcaggccct gccatagaaa tcgataatat 1080 atggtagggt tcatagccag agtaaccttt ttttttaatt tttattttat tttatttttg 1140 agtcgggcgc gccaaaatga agtgaagttc ctatactttc tagagcgagc tcacggggac 1200 agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag ggggcagcag 1260 cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga gccggcagcg 1320 tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct gaacgcttct 1380 cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaagctt taggctgaaa 1440 gagagattta gaatgacagg cgagctcacg gggacagccc ccccccaaag cccccaggga 1500 tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg 1560 tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga 1620 aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac 1680 ctggggggat acggggaaaa agcttgaaac ttgatctgtc gccgcaattc aagcttcgtg 1740 aggctccggt gcccgtcagt gacctgctat actctggaga cgcctctccc ggccagagga 1800 gcaaggtatg cgggaggcga ccaggaggat agcggggctg acgtcgggag gtggcctccg 1860 tgggaaggac acccggatct tgacacagcc ttggcagcgg agtcaggaag agtaggggta 1920 ggttctggac gccctcttgg ccagctcatc gccgccccac cctctgctgg agcacagagt 1980 aattcataca aaaggaggga tcgccttcgc aaggggagag cccagggacc gtccctaaat 2040 tctcacagac ccaaatccct gtagccgccc cacgacagcg cgaggagcat gcgcccaggg 2100 ctgagcgcgg gtagatcaga gcacacaagc tcacagtccc cggcggtggg gggaggggcg 2160 cgctgagcgg gggccaggga gctggcgcgg ggcaaactgg gaaagtggtg tcgtgtgctg 2220 gctccgccct cttcccgagg gtgggggaga acggtatata agtgcggtag tcgccttgga 2280 cgttcttttt cgcaacgggt ttgccgtcag aacgcaggtg agtggcgggt gtggcttccg 2340 cgggccccgg agctggagcc ctgctctgag cgggccgggc tgatatgcga gtgtcgtccg 2400 cagggtttag ctgtgagcat tcccacttcg agtggcgggc ggtgcggggg tgagagtgcg 2460 aggcctagcg gcaaccccgt agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc 2520 cgccgccgcg tgccactccg gccgcactat gcgttttttg tccttgctgc cctcgattgc 2580 cttccagcag catgggctaa caaagggagg gtgtggggct cactcttaag gagcccatga 2640 agcttacgtt ggataggaat ggaagggcag gaggggcgac tggggcccgc ccgccttcgg 2700 agcacatgtc cgacgccacc tggatggggc gaggcctgtg gctttccgaa gcaatcgggc 2760 gtgagtttag cctacctggg ccatgtggcc ctagcactgg gcacggtctg gcctggcggt 2820 gccgcgttcc cttgcctccc aacaagggtg aggccgtccc gcccggcacc agttgcttgc 2880 gcggaaagat ggccgctccc ggggccctgt tgcaaggagc tcaaaatgga ggacgcggca 2940 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggccttg cccctcgccg 3000 gccgctgctt cctgtgaccc cgtggtctat cggccgcata gtcacctcgg gcttctcttg 3060 agcaccgctc gtcgcggcgg ggggagggga tctaatggcg ttggagtttg ttcacatttg 3120 gtgggtggag actagtcagg ccagcctggc gctggaagtc attcttggaa tttgcccctt 3180 tgagtttgga gcgaggctaa ttctcaagcc tcttagcggt tcaaaggtat tttctaaacc 3240 cgtttccagg tgttgtgaaa gccaccgcta attcaaagca agccgccacc 3290 <210> 848 <211> 3284 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 848 ccgcctagga ccaacatctt gagtcccttt atgccgctgt taccaatttt cttttgtctt 60 tgggtataca tttaaaccct aacaaaacaa aaagatgggg atattccctt aacttcatgg 120 gatatgtaat tgggagttgg ggcacatggc cacaggatca tattgtacaa aacttcaaac 180 tatgttttag aaaacttcca ctcaacaaac ctttagatta taaaatctgt gaaaggttaa 240 caggcattct gaattatgtt gctcctttta ctaaatgtgg ttatgctgct ctccttcctt 300 tgtatcaagc tacttcgcgt acggcatttg tgttttcttc tctctaccac agctggttgc 360 tgtcccttta tgctgagttg tggcctgttg ccaggcaacg tggcgtggtg tgctctgtgt 420 ctgacgcaac ccccactggt tggggcttgg ccataggcca tcagcgcatg cgtggaacct 480 ttgtgtctcc tctgccgatc catactgcgg aactcctagc cgcttgtttt gctcgcagct 540 ggactggagc aaacctcatc gggaccgaca attctgtcgt actctcccgc aagtatacat 600 cgtttccatg gctgctcgcc tgtgttgcca actggattct tcgcgggacg tcgttctgct 660 acgtcccttc ggcagcgaat ccggcggacc ttccttcccg aggccttctg ccggctctgc 720 atcccgtgcc gactctccgc ttccgtccgc agctgagtcg catctccctt tgggccgcct 780 ccccgcctgt gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc 840 gctatgacgg caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa 900 acgcggggtt cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg 960 ccaatacgcc cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc 1020 agggctcgca gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta 1080 gggttcatag ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg 1140 gcgcgccaaa atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc 1200 cccccaaagc ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc 1260 gcccggggct ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg 1320 gacagcccgg gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc 1380 tctttgagcc tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga 1440 tttagaatga caggcgagct cacggggaca gccccccccc aaagccccca gggatgtaat 1500 tacgtccctc ccccgctagg gggcagcagc gagccgcccg gggctccgct ccggtccggc 1560 gctccccccg catccccgag ccggcagcgt gcggggacag cccgggcacg gggaaggtgg 1620 cacgggatcg ctttcctctg aacgcttctc gctgctcttt gagcctgcag acacctgggg 1680 ggatacgggg aaaaagcttg aaacttgatc tgtcgccgca attcaagctt cgtgaggctc 1740 cggtgcccgt cagtgacctg ctatactctg gagacgcctc tcccggccag aggagcaagg 1800 tatgcgggag gcgaccagga ggatagcggg gctgacgtcg ggaggtggcc tccgtgggaa 1860 ggacacccgg atcttgacac agccttggca gcggagtcag gaagagtagg ggtaggttct 1920 ggacgccctc ttggccagct catcgccgcc ccaccctctg ctggagcaca gagtaattca 1980 tacaaaagga gggatcgcct tcgcaagggg agagcccagg gaccgtccct aaattctcac 2040 agacccaaat ccctgtagcc gccccacgac agcgcgagga gcatgcgccc agggctgagc 2100 gcgggtagat cagagcacac aagctcacag tccccggcgg tggggggagg ggcgcgctga 2160 gcgggggcca gggagctggc gcggggcaaa ctgggaaagt ggtgtcgtgt gctggctccg 2220 ccctcttccc gagggtgggg gagaacggta tataagtgcg gtagtcgcct tggacgttct 2280 ttttcgcaac gggtttgccg tcagaacgca ggtgagtggc gggtgtggct tccgcgggcc 2340 ccggagctgg agccctgctc tgagcgggcc gggctgatat gcgagtgtcg tccgcagggt 2400 ttagctgtga gcattcccac ttcgagtggc gggcggtgcg ggggtgagag tgcgaggcct 2460 agcggcaacc ccgtagcctc gcctcgtgtc cggcttgagg cctagcgtgg tgtccgccgc 2520 cgcgtgccac tccggccgca ctatgcgttt tttgtccttg ctgccctcga ttgccttcca 2580 gcagcatggg ctaacaaagg gagggtgtgg ggctcactct taaggagccc atgaagctta 2640 cgttggatag gaatggaagg gcaggagggg cgactggggc ccgcccgcct tcggagcaca 2700 tgtccgacgc cacctggatg gggcgaggcc tgtggctttc cgaagcaatc gggcgtgagt 2760 ttagcctacc tgggccatgt ggccctagca ctgggcacgg tctggcctgg cggtgccgcg 2820 ttcccttgcc tcccaacaag ggtgaggccg tcccgcccgg caccagttgc ttgcgcggaa 2880 agatggccgc tcccggggcc ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg 2940 tggagcgggc gggtgagtca cccacacaaa ggaagagggc cttgcccctc gccggccgct 3000 gcttcctgtg accccgtggt ctatcggccg catagtcacc tcgggcttct cttgagcacc 3060 gctcgtcgcg gcggggggag gggatctaat ggcgttggag tttgttcaca tttggtgggt 3120 ggagactagt caggccagcc tggcgctgga agtcattctt ggaatttgcc cctttgagtt 3180 tggagcgagg ctaattctca agcctcttag cggttcaaag gtattttcta aacccgtttc 3240 caggtgttgt gaaagccacc gctaattcaa agcaagccgc cacc 3284 <210> 849 <211> 3241 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 849 ccgcctagga caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta 60 actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta 120 ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt 180 atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg 240 caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt 300 tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag 360 gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc 420 cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc 480 cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc 540 ttccgcctct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc 600 ccatgtatct ttttcacctg tgccttgttt ttgcctgtgt tccatgtcct acttttcaag 660 cctccaagct gtgccttgga tggctttggg gcatggacat agatccctat aaagaatttg 720 gttcatctta tcagttgttg aattttcttc ctttggacat attatcccta atacttgcca 780 ccccactctt aatcagtggt ggaagaacgg tgtcagaact gtttgtttca attggccatt 840 taagtttagt agtaaaagac tggttaatga taacaatgca tcgtaaaacc ttcagaagga 900 aaggagaatg ttttgtggac cactttggtt ttcttttttg cgtgtggcag ttttaagtta 960 ttagttttta aaatcagtac tttttaatgg aaacaacttg accaaaaatt tgtcacagaa 1020 ttttgagatc cattaaaaaa gttaaatgag aaacctgtgt gttcctttgg tcaacaccga 1080 gacatttagg tgaaagcata tactgagatt gagattaact tcctgtgaaa cccagtgtct 1140 tagacaactg tggcttgagc accacctgtt ggtattcatt acaaacttgc tcactacaat 1200 aaatgaattt taagctttaa gatgaagtgg catttctttt aacagttact atgttggaat 1260 tggttacaaa ttttggagtg gactattgta tatatatatc agttactgtt atggatccca 1320 cgtcactatt gtatactcta tattatactc tatgttatac tctgtaatcc tactcaataa 1380 acgtgtcacg cctgtgaaac cgtactaagt ctcccgtgtc ttgttatcac catcaggtga 1440 catcctcgcc caggctgtca atcatgccgg tatcgattcc agtagcaccg gccccacgct 1500 gacaacccac tcttgcagcg ttagcagcgc ccctcttaac aagccgaccc ccaccagcgt 1560 cgcggttact aacactcctc tccccggggc atccgctact cccgagctcg aattcgttta 1620 tcggccaccg aggccaagat ctggccgcca acttacggta aatggcccgc ctggctgacc 1680 gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat 1740 agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt 1800 acatcaagtg tatcatatgc caagtccgcc ccctattgac gtcaatgacg gtaaatggcc 1860 cgcctggcat tatgcccagt acatgacctt acgggacttt cctacttggc agtacatcta 1920 cgtattagtc atcgctatta ccaagtcatt gggtttttcc agccaattta taaaacgcca 1980 tgtactttcc caccattgac gtcaatgggc tattgaaact aatgcaacgt gacctttaaa 2040 cggtactttc ccatagctga ttaatgggaa agtaccgttc tcgagccaat acacgtcaat 2100 gggaagtgaa agggcagcca aaacgtaaca ccgccccggt tttcccctgg aaattccata 2160 ttggcacgca ttctattggc tgagctgcgt tctacgtggg tataagaggc gcgaccagcg 2220 tcggtaggga ccggtttgcc gccagaacac aggtgagggg cgggtgtggc ttccgcgggc 2280 cgccgagctg gaggtcctgc tccgagcggg ccgggccccg ctgtcgtcgg cggggattag 2340 ctgcgagcat tcccgcttcg agttgcgggc ggcgcgggag gcagagtgcg aggcctagcg 2400 gcaaccccgt agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgcgccgccg 2460 ccgcgtgcta ctccggccgc actctggtct tttttttttt tgttgttgtt gccctgctgc 2520 cttcgattgc cgttcagcaa taggggctaa caaagggagg gtgcggggct tgctcgcccg 2580 gagcccggag aggtcatggt tggggaggaa tggagggaca ggagtggcgg ctggggcccg 2640 cccgccttcg gagcacatgt ccgacgccac ctggatgggg cgaggcctgg ggtttttccc 2700 gaagcaacca ggctggggtt agcgtgccga ggccatgtgg ccccagcacc cggcacgatc 2760 tggcttggcg gcgccgcgtt gccctgcctc cctaactagg gtgaggccat cccgtccggc 2820 accagttgcg tgcgtggaaa gatggccgct cccgggccct gttgcaagga gctcaaaatg 2880 gaggacgcgg cagcccggtg gagcgggcgg gtgagtcacc cacacaaagg aagagggcct 2940 ggtccctcac cggctgctgc ttcctgtgac cccgtggtcc tatcggccgc aatagtcacc 3000 tcgggctttt gagcacggct agtcgcggcg gggggagggg atgtaatggc gttggagttt 3060 gttcacattt ggtgggtgga gactagtcag gccagcctgg cgctggaagt catttttgga 3120 atttgtcccc ttgagttttg agcggagcta attctcgggc ttcttagcgg ttcaaaggta 3180 tcttttaaac ccttttttag gtgttgtgaa aaccaccgct aattcaaagc aagccgccac 3240 c 3241 <210> 850 <211> 3095 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 850 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca actcccactg gttggggcat ttgcaccacc tgtcaactca tttccggtac 300 tttcggtttc tcacttccga ttgctaccgc ggagcttata gccgcctgcc ttgctcgctg 360 ctggacagga gctcggttgt tgggcactga taactccgtg gtcctctccg gtaagctaac 420 ttcgtttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcgtctgc cccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgcct gtatattatc cctaatactt gccaccccac tcttaatcag tggtggaaga 660 acggtgtcag aactgtttgt ttcaattggc catttaagtt tagtagtaaa agactggtta 720 atgataacaa tgcatcgtaa aaccttcaga aggaaaggag aatgttttgt ggaccacttt 780 ggttttcttt tttgcgtgtg gcagttttaa gttattagtt tttaaaatca gtacttttta 840 atggaaacaa cttgaccaaa aatttgtcac agaattttga gatccattaa aaaagttaaa 900 tgagaaacct gtgtgttcct ttggtcaaca ccgagacatt taggtgaaag catatactga 960 gattgagatt aacttcctgt gaaacccagt gtcttagaca actgtggctt gagcaccacc 1020 tgttggtatt cattacaaac ttgctcacta caataaatga attttaagct ttaagatgaa 1080 gtggcatttc ttttaacagt tactatgttg gaattggtta caaattttgg agtggactat 1140 tgtatatata tatcagttac tgttatggat cccacgtcac tattgtatac tctatattat 1200 actctatgtt atactctgta atcctactca ataaacgtgt cacgcctgtg aaaccgtact 1260 aagtctcccg tgtcttgtta tcaccatcag gtgacatcct cgcccaggct gtcaatcatg 1320 ccggtatcga ttccagtagc accggcccca cgctgacaac ccactcttgc agcgttagca 1380 gcgcccctct taacaagccg acccccacca gcgtcgcggt tactaacact cctctccccg 1440 gggcatccgc tactcccgag ctcgaattcg tttatcggcc accgaggcca agatctggcc 1500 gccaacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt 1560 caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg 1620 tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc 1680 cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga 1740 ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccaagt 1800 cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat tgacgtcaat 1860 gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag ctgattaatg 1920 ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca gccaaaacgt 1980 aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat tggctgagct 2040 gcgttctacg tgggtataag aggcgcgacc agcgtcggta gggaccggtt tgccgccaga 2100 acacaggtga ggggcgggtg tggcttccgc gggccgccga gctggaggtc ctgctccgag 2160 cgggccgggc cccgctgtcg tcggcgggga ttagctgcga gcattcccgc ttcgagttgc 2220 gggcggcgcg ggaggcagag tgcgaggcct agcggcaacc ccgtagcctc gcctcgtgtc 2280 cggcttgagg cctagcgtgg tgtccgcgcc gccgccgcgt gctactccgg ccgcactctg 2340 gtcttttttt tttttgttgt tgttgccctg ctgccttcga ttgccgttca gcaatagggg 2400 ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc ggagaggtca tggttgggga 2460 ggaatggagg gacaggagtg gcggctgggg cccgcccgcc ttcggagcac atgtccgacg 2520 ccacctggat ggggcgaggc ctggggtttt tcccgaagca accaggctgg ggttagcgtg 2580 ccgaggccat gtggccccag cacccggcac gatctggctt ggcggcgccg cgttgccctg 2640 cctccctaac tagggtgagg ccatcccgtc cggcaccagt tgcgtgcgtg gaaagatggc 2700 cgctcccggg ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg 2760 gcgggtgagt cacccacaca aaggaagagg gcctggtccc tcaccggctg ctgcttcctg 2820 tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc ttttgagcac ggctagtcgc 2880 ggcgggggga ggggatgtaa tggcgttgga gtttgttcac atttggtggg tggagactag 2940 tcaggccagc ctggcgctgg aagtcatttt tggaatttgt ccccttgagt tttgagcgga 3000 gctaattctc gggcttctta gcggttcaaa ggtatctttt aaaccctttt ttaggtgttg 3060 tgaaaaccac cgctaattca aagcaagccg ccacc 3095 <210> 851 <211> 3279 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 851 ccgcctagga ccaacatctt gagtcccttt atgccgctgt taccaatttt cttttgtctt 60 tgggtataca tttaaaccct aacaaaacaa aaagatgggg atattccctt aacttcatgg 120 gatatgtaat tgggagttgg ggcacatggc cacaggatca tattgtacaa aacttcaaac 180 tatgttttag aaaacttcct gttaatcaac ctctggatta caaaatttgt gaaagattga 240 ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 300 tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 360 tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg 420 tgtttgctga cgcaaccccc actggttggg gcatttgcac cacctatcaa ctcatttccc 480 cgacgggcgc ttttgccctg ccgatcgcca ccgcggacgt catcgccgcc tgccttgctc 540 gctgctggac aggagctcgg ctgttgggca ctgacaactc cgtggttctt tcgggcaaac 600 tgacttccta tccatggctg ctcgcctgtg ttgccaactg gattcttcgc gggacgtcct 660 tctgttacgt cccctccgcg gacaacccag cggaccttcc ttcccgggga cttctgccgg 720 ctctccgtcc tctgccgctt ctgcgttttc gtccggtcac caagcggata tccctgtggg 780 ccgcctcccc gcctgtatat tatccctaat acttgccacc ccactcttaa tcagtggtgg 840 aagaacggtg tcagaactgt ttgtttcaat tggccattta agtttagtag taaaagactg 900 gttaatgata acaatgcatc gtaaaacctt cagaaggaaa ggagaatgtt ttgtggacca 960 ctttggtttt cttttttgcg tgtggcagtt ttaagttatt agtttttaaa atcagtactt 1020 tttaatggaa acaacttgac caaaaatttg tcacagaatt ttgagatcca ttaaaaaagt 1080 taaatgagaa acctgtgtgt tcctttggtc aacaccgaga catttaggtg aaagcatata 1140 ctgagattga gattaacttc ctgtgaaacc cagtgtctta gacaactgtg gcttgagcac 1200 cacctgttgg tattcattac aaacttgctc actacaataa atgaatttta agctttaaga 1260 tgaagtggca tttcttttaa cagttactat gttggaattg gttacaaatt ttggagtgga 1320 ctattgtata tatatatcag ttactgttat ggatcccacg tcactattgt atactctata 1380 ttatactcta tgttatactc tgtaatccta ctcaataaac gtgtcacgcc tgtgaaaccg 1440 tactaagtct cccgtgtctt gttatcacca tcaggtgaca tcctcgccca ggctgtcaat 1500 catgccggta tcgattccag tagcaccggc cccacgctga caacccactc ttgcagcgtt 1560 agcagcgccc ctcttaacaa gccgaccccc accagcgtcg cggttactaa cactcctctc 1620 cccggggcat ccgctactcc cgagctcgaa ttcgtttatc ggccaccgag gccaagatct 1680 ggccgccaac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 1740 acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 1800 tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 1860 agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 1920 atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 1980 aagtcattgg gtttttccag ccaatttata aaacgccatg tactttccca ccattgacgt 2040 caatgggcta ttgaaactaa tgcaacgtga cctttaaacg gtactttccc atagctgatt 2100 aatgggaaag taccgttctc gagccaatac acgtcaatgg gaagtgaaag ggcagccaaa 2160 acgtaacacc gccccggttt tcccctggaa attccatatt ggcacgcatt ctattggctg 2220 agctgcgttc tacgtgggta taagaggcgc gaccagcgtc ggtagggacc ggtttgccgc 2280 cagaacacag gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc 2340 cgagcgggcc gggccccgct gtcgtcggcg gggattagct gcgagcattc ccgcttcgag 2400 ttgcgggcgg cgcgggaggc agagtgcgag gcctagcggc aaccccgtag cctcgcctcg 2460 tgtccggctt gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac 2520 tctggtcttt tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata 2580 ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg 2640 gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc 2700 gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag 2760 cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc 2820 cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga 2880 tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga 2940 gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt 3000 cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag 3060 tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga 3120 ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag 3180 cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttaggt 3240 gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 3279 <210> 852 <211> 3215 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 852 ccgcctagga cttccactca acaaaccttt agattataaa atctgtgaaa ggttaacagg 60 cattctgaat tatgttgctc cttttactaa atgtggttat gctgctctcc ttcctttgta 120 tcaagctact tcgcgtacgg catttgtgtt ttcttctctc taccacagct ggttgctgtc 180 cctttatgct gagttgtggc ctgttgccag gcaacgtggc gtggtgtgct ctgtgtctga 240 cgcaaccccc actggttggg gcatttgcac cacctatcaa ctcatttccc cgacgggcgc 300 ttttgccctg ccgatcgcca ccgcggacgt catcgccgcc tgccttgctc gctgctggac 360 aggagctcgg ctgttgggca ctgacaactc cgtggttctt tcgggcaaac tgacttccta 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacctg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgatattatc cctaatactt gccaccccac tcttaatcag tggtggaaga 780 acggtgtcag aactgtttgt ttcaattggc catttaagtt tagtagtaaa agactggtta 840 atgataacaa tgcatcgtaa aaccttcaga aggaaaggag aatgttttgt ggaccacttt 900 ggttttcttt tttgcgtgtg gcagttttaa gttattagtt tttaaaatca gtacttttta 960 atggaaacaa cttgaccaaa aatttgtcac agaattttga gatccattaa aaaagttaaa 1020 tgagaaacct gtgtgttcct ttggtcaaca ccgagacatt taggtgaaag catatactga 1080 gattgagatt aacttcctgt gaaacccagt gtcttagaca actgtggctt gagcaccacc 1140 tgttggtatt cattacaaac ttgctcacta caataaatga attttaagct ttaagatgaa 1200 gtggcatttc ttttaacagt tactatgttg gaattggtta caaattttgg agtggactat 1260 tgtatatata tatcagttac tgttatggat cccacgtcac tattgtatac tctatattat 1320 actctatgtt atactctgta atcctactca ataaacgtgt cacgcctgtg aaaccgtact 1380 aagtctcccg tgtcttgtta tcaccatcag gtgacatcct cgcccaggct gtcaatcatg 1440 ccggtatcga ttccagtagc accggcccca cgctgacaac ccactcttgc agcgttagca 1500 gcgcccctct taacaagccg acccccacca gcgtcgcggt tactaacact cctctccccg 1560 gggcatccgc tactcccgag ctcgaattcg tttatcggcc accgaggcca agatctggcc 1620 gccaacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt 1680 caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg 1740 tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc 1800 cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga 1860 ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccaagt 1920 cattgggttt ttccagccaa tttataaaac gccatgtact ttcccaccat tgacgtcaat 1980 gggctattga aactaatgca acgtgacctt taaacggtac tttcccatag ctgattaatg 2040 ggaaagtacc gttctcgagc caatacacgt caatgggaag tgaaagggca gccaaaacgt 2100 aacaccgccc cggttttccc ctggaaattc catattggca cgcattctat tggctgagct 2160 gcgttctacg tgggtataag aggcgcgacc agcgtcggta gggaccggtt tgccgccaga 2220 acacaggtga ggggcgggtg tggcttccgc gggccgccga gctggaggtc ctgctccgag 2280 cgggccgggc cccgctgtcg tcggcgggga ttagctgcga gcattcccgc ttcgagttgc 2340 gggcggcgcg ggaggcagag tgcgaggcct agcggcaacc ccgtagcctc gcctcgtgtc 2400 cggcttgagg cctagcgtgg tgtccgcgcc gccgccgcgt gctactccgg ccgcactctg 2460 gtcttttttt tttttgttgt tgttgccctg ctgccttcga ttgccgttca gcaatagggg 2520 ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc ggagaggtca tggttgggga 2580 ggaatggagg gacaggagtg gcggctgggg cccgcccgcc ttcggagcac atgtccgacg 2640 ccacctggat ggggcgaggc ctggggtttt tcccgaagca accaggctgg ggttagcgtg 2700 ccgaggccat gtggccccag cacccggcac gatctggctt ggcggcgccg cgttgccctg 2760 cctccctaac tagggtgagg ccatcccgtc cggcaccagt tgcgtgcgtg gaaagatggc 2820 cgctcccggg ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg 2880 gcgggtgagt cacccacaca aaggaagagg gcctggtccc tcaccggctg ctgcttcctg 2940 tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc ttttgagcac ggctagtcgc 3000 ggcgggggga ggggatgtaa tggcgttgga gtttgttcac atttggtggg tggagactag 3060 tcaggccagc ctggcgctgg aagtcatttt tggaatttgt ccccttgagt tttgagcgga 3120 gctaattctc gggcttctta gcggttcaaa ggtatctttt aaaccctttt ttaggtgttg 3180 tgaaaaccac cgctaattca aagcaagccg ccacc 3215 <210> 853 <211> 3279 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 853 ccgcctagga cgagcatctt accgccattt attcccatat ttgctctgtt tttcttgatt 60 tgggcataca tttaaatgta gccaaaacta aatggtgggg acatcattta catttcatgg 120 gttatgttat tactggagca ggaattttac cccaagataa acatgtgcaa aaagtatcaa 180 catatttgaa atccattcct gtaaacaggc ctattgattg gaaagtttgt caacgaattg 240 tgggtctttt ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt 300 tatatgcatg tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc 360 tcagtaaaca gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag 420 tgtttgctga cgcaactccc actggttggg gcatttgcac cacctgtcaa ctcatttccg 480 gtactttcgg tttctcactt ccgattgcta ccgcggagct tatagccgcc tgccttgctc 540 gctgctggac aggagctcgg ttgttgggca ctgataactc cgtggtcctc tccggtaagc 600 taacttcgtt tccatggctg ctcgcctgtg ttgccaactg gattcttcgc gggacgtcgt 660 tctgctacgt cccttcggca gcgaatccgg cggaccttcc ttcccgaggc cttctgccgg 720 ctctgcatcc cgtgccgact ctccgcttcc gtccgcagct gagtcgcatc tccctttggg 780 ccgcctcccc gcctgtatat tatccctaat acttgccacc ccactcttaa tcagtggtgg 840 aagaacggtg tcagaactgt ttgtttcaat tggccattta agtttagtag taaaagactg 900 gttaatgata acaatgcatc gtaaaacctt cagaaggaaa ggagaatgtt ttgtggacca 960 ctttggtttt cttttttgcg tgtggcagtt ttaagttatt agtttttaaa atcagtactt 1020 tttaatggaa acaacttgac caaaaatttg tcacagaatt ttgagatcca ttaaaaaagt 1080 taaatgagaa acctgtgtgt tcctttggtc aacaccgaga catttaggtg aaagcatata 1140 ctgagattga gattaacttc ctgtgaaacc cagtgtctta gacaactgtg gcttgagcac 1200 cacctgttgg tattcattac aaacttgctc actacaataa atgaatttta agctttaaga 1260 tgaagtggca tttcttttaa cagttactat gttggaattg gttacaaatt ttggagtgga 1320 ctattgtata tatatatcag ttactgttat ggatcccacg tcactattgt atactctata 1380 ttatactcta tgttatactc tgtaatccta ctcaataaac gtgtcacgcc tgtgaaaccg 1440 tactaagtct cccgtgtctt gttatcacca tcaggtgaca tcctcgccca ggctgtcaat 1500 catgccggta tcgattccag tagcaccggc cccacgctga caacccactc ttgcagcgtt 1560 agcagcgccc ctcttaacaa gccgaccccc accagcgtcg cggttactaa cactcctctc 1620 cccggggcat ccgctactcc cgagctcgaa ttcgtttatc ggccaccgag gccaagatct 1680 ggccgccaac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 1740 acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 1800 tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 1860 agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 1920 atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 1980 aagtcattgg gtttttccag ccaatttata aaacgccatg tactttccca ccattgacgt 2040 caatgggcta ttgaaactaa tgcaacgtga cctttaaacg gtactttccc atagctgatt 2100 aatgggaaag taccgttctc gagccaatac acgtcaatgg gaagtgaaag ggcagccaaa 2160 acgtaacacc gccccggttt tcccctggaa attccatatt ggcacgcatt ctattggctg 2220 agctgcgttc tacgtgggta taagaggcgc gaccagcgtc ggtagggacc ggtttgccgc 2280 cagaacacag gtgaggggcg ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc 2340 cgagcgggcc gggccccgct gtcgtcggcg gggattagct gcgagcattc ccgcttcgag 2400 ttgcgggcgg cgcgggaggc agagtgcgag gcctagcggc aaccccgtag cctcgcctcg 2460 tgtccggctt gaggcctagc gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac 2520 tctggtcttt tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata 2580 ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg 2640 gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc 2700 gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag 2760 cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc 2820 cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga 2880 tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga 2940 gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt 3000 cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag 3060 tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga 3120 ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag 3180 cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttaggt 3240 gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 3279 <210> 854 <211> 3273 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 854 ccgcctagga ccaacatctt gagtcccttt atgccgctgt taccaatttt cttttgtctt 60 tgggtataca tttaaaccct aacaaaacaa aaagatgggg atattccctt aacttcatgg 120 gatatgtaat tgggagttgg ggcacatggc cacaggatca tattgtacaa aacttcaaac 180 tatgttttag aaaacttcca ctcaacaaac ctttagatta taaaatctgt gaaaggttaa 240 caggcattct gaattatgtt gctcctttta ctaaatgtgg ttatgctgct ctccttcctt 300 tgtatcaagc tacttcgcgt acggcatttg tgttttcttc tctctaccac agctggttgc 360 tgtcccttta tgctgagttg tggcctgttg ccaggcaacg tggcgtggtg tgctctgtgt 420 ctgacgcaac ccccactggt tggggcttgg ccataggcca tcagcgcatg cgtggaacct 480 ttgtgtctcc tctgccgatc catactgcgg aactcctagc cgcttgtttt gctcgcagct 540 ggactggagc aaacctcatc gggaccgaca attctgtcgt actctcccgc aagtatacat 600 cgtttccatg gctgctcgcc tgtgttgcca actggattct tcgcgggacg tcgttctgct 660 acgtcccttc ggcagcgaat ccggcggacc ttccttcccg aggccttctg ccggctctgc 720 atcccgtgcc gactctccgc ttccgtccgc agctgagtcg catctccctt tgggccgcct 780 ccccgcctgt atattatccc taatacttgc caccccactc ttaatcagtg gtggaagaac 840 ggtgtcagaa ctgtttgttt caattggcca tttaagttta gtagtaaaag actggttaat 900 gataacaatg catcgtaaaa ccttcagaag gaaaggagaa tgttttgtgg accactttgg 960 ttttcttttt tgcgtgtggc agttttaagt tattagtttt taaaatcagt actttttaat 1020 ggaaacaact tgaccaaaaa tttgtcacag aattttgaga tccattaaaa aagttaaatg 1080 agaaacctgt gtgttccttt ggtcaacacc gagacattta ggtgaaagca tatactgaga 1140 ttgagattaa cttcctgtga aacccagtgt cttagacaac tgtggcttga gcaccacctg 1200 ttggtattca ttacaaactt gctcactaca ataaatgaat tttaagcttt aagatgaagt 1260 ggcatttctt ttaacagtta ctatgttgga attggttaca aattttggag tggactattg 1320 tatatatata tcagttactg ttatggatcc cacgtcacta ttgtatactc tatattatac 1380 tctatgttat actctgtaat cctactcaat aaacgtgtca cgcctgtgaa accgtactaa 1440 gtctcccgtg tcttgttatc accatcaggt gacatcctcg cccaggctgt caatcatgcc 1500 ggtatcgatt ccagtagcac cggccccacg ctgacaaccc actcttgcag cgttagcagc 1560 gcccctctta acaagccgac ccccaccagc gtcgcggtta ctaacactcc tctccccggg 1620 gcatccgcta ctcccgagct cgaattcgtt tatcggccac cgaggccaag atctggccgc 1680 caacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca 1740 ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg 1800 gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg 1860 ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc 1920 ttacgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccaagtca 1980 ttgggttttt ccagccaatt tataaaacgc catgtacttt cccaccattg acgtcaatgg 2040 gctattgaaa ctaatgcaac gtgaccttta aacggtactt tcccatagct gattaatggg 2100 aaagtaccgt tctcgagcca atacacgtca atgggaagtg aaagggcagc caaaacgtaa 2160 caccgccccg gttttcccct ggaaattcca tattggcacg cattctattg gctgagctgc 2220 gttctacgtg ggtataagag gcgcgaccag cgtcggtagg gaccggtttg ccgccagaac 2280 acaggtgagg ggcgggtgtg gcttccgcgg gccgccgagc tggaggtcct gctccgagcg 2340 ggccgggccc cgctgtcgtc ggcggggatt agctgcgagc attcccgctt cgagttgcgg 2400 gcggcgcggg aggcagagtg cgaggcctag cggcaacccc gtagcctcgc ctcgtgtccg 2460 gcttgaggcc tagcgtggtg tccgcgccgc cgccgcgtgc tactccggcc gcactctggt 2520 cttttttttt tttgttgttg ttgccctgct gccttcgatt gccgttcagc aataggggct 2580 aacaaaggga gggtgcgggg cttgctcgcc cggagcccgg agaggtcatg gttggggagg 2640 aatggaggga caggagtggc ggctggggcc cgcccgcctt cggagcacat gtccgacgcc 2700 acctggatgg ggcgaggcct ggggtttttc ccgaagcaac caggctgggg ttagcgtgcc 2760 gaggccatgt ggccccagca cccggcacga tctggcttgg cggcgccgcg ttgccctgcc 2820 tccctaacta gggtgaggcc atcccgtccg gcaccagttg cgtgcgtgga aagatggccg 2880 ctcccgggcc ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg tggagcgggc 2940 gggtgagtca cccacacaaa ggaagagggc ctggtccctc accggctgct gcttcctgtg 3000 accccgtggt cctatcggcc gcaatagtca cctcgggctt ttgagcacgg ctagtcgcgg 3060 cggggggagg ggatgtaatg gcgttggagt ttgttcacat ttggtgggtg gagactagtc 3120 aggccagcct ggcgctggaa gtcatttttg gaatttgtcc ccttgagttt tgagcggagc 3180 taattctcgg gcttcttagc ggttcaaagg tatcttttaa accctttttt aggtgttgtg 3240 aaaaccaccg ctaattcaaa gcaagccgcc acc 3273 <210> 855 <211> 1686 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 855 gagcatctta ccgccattta ttcccatatt tgctctgttt ttcttgattt gggcatacat 60 ttaaatgtag ccaaaactaa atggtgggga catcatttac atttcatggg ttatgttatt 120 actggagcag gaattttacc ccaagataaa catgtgcaaa aagtatcaac atatttgaaa 180 tccattcctg taaacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg 240 gggtttgctg ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt 300 atacaagcaa aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag 360 tatatgaccc tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac 420 gcaactccca ctggttgggg catttgcacc acctgtcaac tcatttccgg tactttcggt 480 ttctcacttc cgattgctac cgcggagctt atagccgcct gccttgctcg ctgctggaca 540 ggagctcggt tgttgggcac tgataactcc gtggtcctct ccggtaagct aacttcgttt 600 ccatggctgc tcgcctgtgt tgccaactgg attcttcgcg ggacgtcgtt ctgctacgtc 660 ccttcggcag cgaatccggc ggaccttcct tcccgaggcc ttctgccggc tctgcatccc 720 gtgccgactc tccgcttccg tccgcagctg agtcgcatct ccctttgggc cgcctccccg 780 cctgttgtat actctatatt atactctatg ttatactctg taatcctact caataaacgt 840 gtcacgcctg tgaaaccgta ctaagtctcc cgtgtcttct tatcaccatc aggtgacatc 900 ctcgcccagg ctgtcaatca tgccggtatc gattccagta gcaccggccc cacgctgaca 960 acccactctt gcagcgttag cagcgcccct cttaacaagc cgacccccac cagcgtcgcg 1020 gttactaaca ctcctctccc cggggcatcc gctactcccg agctcggccg ccatatactg 1080 agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca 1140 acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt 1200 gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacgta 1260 cataaggtca ataggggtga gtcattgggt ttttccagcc aatttataaa acgccatgta 1320 ctttcccacc attgacgtca atgggctatt gaaactaatg caacgtgacc tttaaacggt 1380 actttcccat agctgattaa tgggaaagta ccgttctcga gccaatacac gtcaatggga 1440 agtgaaaggg cagccaaaac gtaacaccgc cccggttttc ccctggaaat tccatattgg 1500 cacgcattct attggctgag ctgcgttcta cgtgggtata agaggcgcga ccagcgtcgg 1560 taccgtcgca gtcttgggtc tgaccaccgt agaacgcaga gctcctcgct gcagtatcct 1620 gcccaagaaa gagcgacccg tctcaggggc ttcgcaggta cacccaagct gtctagagcc 1680 gccacc 1686 <210> 856 <211> 1680 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 856 caacatcttg agtcccttta tgccgctgtt accaattttc ttttgtcttt gggtatacat 60 ttaaacccta acaaaacaaa aagatgggga tattccctta acttcatggg atatgtaatt 120 gggagttggg gcacatggcc acaggatcat attgtacaaa acttcaaact atgttttaga 180 aaacttccac tcaacaaacc tttagattat aaaatctgtg aaaggttaac aggcattctg 240 aattatgttg ctccttttac taaatgtggt tatgctgctc tccttccttt gtatcaagct 300 acttcgcgta cggcatttgt gttttcttct ctctaccaca gctggttgct gtccctttat 360 gctgagttgt ggcctgttgc caggcaacgt ggcgtggtgt gctctgtgtc tgacgcaacc 420 cccactggtt ggggcttggc cataggccat cagcgcatgc gtggaacctt tgtgtctcct 480 ctgccgatcc atactgcgga actcctagcc gcttgttttg ctcgcagctg gactggagca 540 aacctcatcg ggaccgacaa ttctgtcgta ctctcccgca agtatacatc gtttccatgg 600 ctgctcgcct gtgttgccaa ctggattctt cgcgggacgt cgttctgcta cgtcccttcg 660 gcagcgaatc cggcggacct tccttcccga ggccttctgc cggctctgca tcccgtgccg 720 actctccgct tccgtccgca gctgagtcgc atctcccttt gggccgcctc cccgcctgtt 780 gtatactcta tattatactc tatgttatac tctgtaatcc tactcaataa acgtgtcacg 840 cctgtgaaac cgtactaagt ctcccgtgtc ttcttatcac catcaggtga catcctcgcc 900 caggctgtca atcatgccgg tatcgattcc agtagcaccg gccccacgct gacaacccac 960 tcttgcagcg ttagcagcgc ccctcttaac aagccgaccc ccaccagcgt cgcggttact 1020 aacactcctc tccccggggc atccgctact cccgagctcg gccgccatat actgagtcat 1080 tagggacttt ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga 1140 aagtcccatt ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag 1200 tacaaaaggt caataggggg tgagtcaatg ggtttttccc attattggca cgtacataag 1260 gtcaataggg gtgagtcatt gggtttttcc agccaattta taaaacgcca tgtactttcc 1320 caccattgac gtcaatgggc tattgaaact aatgcaacgt gacctttaaa cggtactttc 1380 ccatagctga ttaatgggaa agtaccgttc tcgagccaat acacgtcaat gggaagtgaa 1440 agggcagcca aaacgtaaca ccgccccggt tttcccctgg aaattccata ttggcacgca 1500 ttctattggc tgagctgcgt tctacgtggg tataagaggc gcgaccagcg tcggtaccgt 1560 cgcagtcttg ggtctgacca ccgtagaacg cagagctcct cgctgcagta tcctgcccaa 1620 gaaagagcga cccgtctcag gggcttcgca ggtacaccca agctgtctag agccgccacc 1680 <210> 857 <211> 3235 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 857 gagcatctta ccgccattta ttcccatatt tgctctgttt ttcttgattt gggcatacat 60 ttaaatgtag ccaaaactaa atggtgggga catcatttac atttcatggg ttatgttatt 120 actggagcag gaattttacc ccaagataaa catgtgcaaa aagtatcaac atatttgaaa 180 tccattcctg taaacaggcc tattgattgg aaagtttgtc aacgaattgt gggtcttttg 240 gggtttgctg ccccttttac gcaatgtgga tatcctgctt taatgccttt atatgcatgt 300 atacaagcaa aacaggcttt tactttctcg ccaacttaca aggcctttct cagtaaacag 360 tatatgaccc tttaccccgt tgctcggcaa cggcctggtc tgtgccaagt gtttgctgac 420 gcaactccca ctggttgggg catttgcacc acctgtcaac tcatttccgg tactttcggt 480 ttctcacttc cgattgctac cgcggagctt atagccgcct gccttgctcg ctgctggaca 540 ggagctcggt tgttgggcac tgataactcc gtggtcctct ccggtaagct aacttcgttt 600 ccatggctgc tcgcctgtgt tgccaactgg attcttcgcg ggacgtcgtt ctgctacgtc 660 ccttcggcag cgaatccggc ggaccttcct tcccgaggcc ttctgccggc tctgcatccc 720 gtgccgactc tccgcttccg tccgcagctg agtcgcatct ccctttgggc cgcctccccg 780 cctgtatcgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 840 tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 900 gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagtccc cattggggcc 960 aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 1020 ggctcgcagc caacgtcggg gcggcaggcc ctgccataga aatcgataat atatggtagg 1080 gttcatagcc agagtaacct ttttttttaa tttttatttt attttatttt tgagtcgggc 1140 gcgccaaaat gaagtgaagt tcctatactt tctagagcga gctcacgggg acagcccccc 1200 cccaaagccc ccagggatgt aattacgtcc ctcccccgct agggggcagc agcgagccgc 1260 ccggggctcc gctccggtcc ggcgctcccc ccgcatcccc gagccggcag cgtgcgggga 1320 cagcccgggc acggggaagg tggcacggga tcgctttcct ctgaacgctt ctcgctgctc 1380 tttgagcctg cagacacctg gggggatacg gggaaaaagc tttaggctga aagagagatt 1440 tagaatgaca ggcgagctca cggggacagc ccccccccaa agcccccagg gatgtaatta 1500 cgtccctccc ccgctagggg gcagcagcga gccgcccggg gctccgctcc ggtccggcgc 1560 tccccccgca tccccgagcc ggcagcgtgc ggggacagcc cgggcacggg gaaggtggca 1620 cgggatcgct ttcctctgaa cgcttctcgc tgctctttga gcctgcagac acctgggggg 1680 atacggggaa aaagcttgaa acttgatctg tcgccgcaat tcaagcttcg tgaggctccg 1740 gtgcccgtca gtgacctgct atactctgga gacgagcggg gctgacgtcg ggaggtggcc 1800 tccgtgggaa gggacacccg gatcttgaca cagccttggc agcggagtaa ggaagagtag 1860 ggatagattc tggccgccct cttggccagc ttctcgccgc cccaccctcc gctagggcca 1920 agagtaattc atacaaaagg agggatcgcc ttcgcaaggg gagagcccag ggaccgtccc 1980 taaattctca cagacccaaa tccctgtagc cgccccacga cagcgcgagg agcatgcgct 2040 cagggctgag cgcggggaga gcagagcaca caagctcata gaccctggtc gtggggggga 2100 ggaccgggga gctggcgcgg ggcaaactgg gaaagcggtg tcgtgtgctg gctccgccct 2160 cttcccgagg gtgggggaga acggtatata agtgcggcag tcgccttgga cgttcttttt 2220 cgcaacgggt ttgccgtcag aacgcaggtg aggggcgggt gtggcttccg cgggccgccg 2280 agctggaggt cctgctccga gcgggccggg ccccgctgtc gtcggcgggg attagctgcg 2340 agcattcccg cttcgagttg cgggcggcgc gggaggcaga gtgcgaggcc tagcggcaac 2400 cccgtagcct cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgcgc cgccgccgcg 2460 tgctactccg gccgcactct ggtctttttt tttttgttgt tgttgccctg ctgccttcga 2520 ttgccgttca gcaatagggg ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc 2580 ggagaggtca tggttgggga ggaatggagg gacaggagtg gcggctgggg cccgcccgcc 2640 ttcggagcac atgtccgacg ccacctggat ggggcgaggc ctggggtttt tcccgaagca 2700 accaggctgg ggttagcgtg ccgaggccat gtggccccag cacccggcac gatctggctt 2760 ggcggcgccg cgttgccctg cctccctaac tagggtgagg ccatcccgtc cggcaccagt 2820 tgcgtgcgtg gaaagatggc cgctcccggg ccctgttgca aggagctcaa aatggaggac 2880 gcggcagccc ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gcctggtccc 2940 tcaccggctg ctgcttcctg tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc 3000 ttttgagcac ggctagtcgc ggcgggggga ggggatgtaa tggcgttgga gtttgttcac 3060 atttggtggg tggagactag tcaggccagc ctggcgctgg aagtcatttt tggaatttgt 3120 ccccttgagt tttgagcgga gctaattctc gggcttctta gcggttcaaa ggtatctttt 3180 aaaccctttt ttaggtgttg tgaaaaccac cgctaattca aagcaagccg ccacc 3235 <210> 858 <211> 3229 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 858 caacatcttg agtcccttta tgccgctgtt accaattttc ttttgtcttt gggtatacat 60 ttaaacccta acaaaacaaa aagatgggga tattccctta acttcatggg atatgtaatt 120 gggagttggg gcacatggcc acaggatcat attgtacaaa acttcaaact atgttttaga 180 aaacttccac tcaacaaacc tttagattat aaaatctgtg aaaggttaac aggcattctg 240 aattatgttg ctccttttac taaatgtggt tatgctgctc tccttccttt gtatcaagct 300 acttcgcgta cggcatttgt gttttcttct ctctaccaca gctggttgct gtccctttat 360 gctgagttgt ggcctgttgc caggcaacgt ggcgtggtgt gctctgtgtc tgacgcaacc 420 cccactggtt ggggcttggc cataggccat cagcgcatgc gtggaacctt tgtgtctcct 480 ctgccgatcc atactgcgga actcctagcc gcttgttttg ctcgcagctg gactggagca 540 aacctcatcg ggaccgacaa ttctgtcgta ctctcccgca agtatacatc gtttccatgg 600 ctgctcgcct gtgttgccaa ctggattctt cgcgggacgt cgttctgcta cgtcccttcg 660 gcagcgaatc cggcggacct tccttcccga ggccttctgc cggctctgca tcccgtgccg 720 actctccgct tccgtccgca gctgagtcgc atctcccttt gggccgcctc cccgcctgta 780 tcgggggagg ctaactgaaa cacggaagga gacaataccg gaaggaaccc gcgctatgac 840 ggcaataaaa agacagaata aaacgcacgg gtgttgggtc gtttgttcat aaacgcgggg 900 ttcggtccca gggctggcac tctgtcgata ccccaccgag tccccattgg ggccaatacg 960 cccgcgtttc ttccttttcc ccaccccacc ccccaagttc gggtgaaggc ccagggctcg 1020 cagccaacgt cggggcggca ggccctgcca tagaaatcga taatatatgg tagggttcat 1080 agccagagta accttttttt ttaattttta ttttatttta tttttgagtc gggcgcgcca 1140 aaatgaagtg aagttcctat actttctaga gcgagctcac ggggacagcc cccccccaaa 1200 gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg 1260 ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc 1320 gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag 1380 cctgcagaca cctgggggga tacggggaaa aagctttagg ctgaaagaga gatttagaat 1440 gacaggcgag ctcacgggga cagccccccc ccaaagcccc cagggatgta attacgtccc 1500 tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg gcgctccccc 1560 cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt ggcacgggat 1620 cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg ggggatacgg 1680 ggaaaaagct tgaaacttga tctgtcgccg caattcaagc ttcgtgaggc tccggtgccc 1740 gtcagtgacc tgctatactc tggagacgag cggggctgac gtcgggaggt ggcctccgtg 1800 ggaagggaca cccggatctt gacacagcct tggcagcgga gtaaggaaga gtagggatag 1860 attctggccg ccctcttggc cagcttctcg ccgccccacc ctccgctagg gccaagagta 1920 attcatacaa aaggagggat cgccttcgca aggggagagc ccagggaccg tccctaaatt 1980 ctcacagacc caaatccctg tagccgcccc acgacagcgc gaggagcatg cgctcagggc 2040 tgagcgcggg gagagcagag cacacaagct catagaccct ggtcgtgggg gggaggaccg 2100 gggagctggc gcggggcaaa ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc 2160 gagggtgggg gagaacggta tataagtgcg gcagtcgcct tggacgttct ttttcgcaac 2220 gggtttgccg tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg 2280 aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt 2340 cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta 2400 gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac 2460 tccggccgca ctctggtctt tttttttttg ttgttgttgc cctgctgcct tcgattgccg 2520 ttcagcaata ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag 2580 gtcatggttg gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga 2640 gcacatgtcc gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg 2700 ctggggttag cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc 2760 gccgcgttgc cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg 2820 cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca 2880 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg 2940 gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga 3000 gcacggctag tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg 3060 tgggtggaga ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt 3120 gagttttgag cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc 3180 ttttttaggt gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 3229 <210> 859 <211> 2184 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 859 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaagcggggc tgacgtcggg aggtggcctc cgtgggaagg 720 gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg atagattctg 780 gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag agtaattcat 840 acaaaaggag ggatcgcctt cgcctgggga agtcccaggg accgtcgcta aattctcata 900 acccataatc ccggtacccg ccccaccaca gtgcgaggag catgcgctca gggctgagcg 960 cggggagagc agagcacaca agctcataga ccctggtcgt ggggggaggg gcgcactgag 1020 cggggggggg gggggtgatg ggggggagga ccggggagct ggcgcggggc aaactgggaa 1080 agcggtgtcg tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtatataagt 1140 gcggcagtcg ccttggacgt tcctttttcg caacgggttt gccgtcagaa cgcaggtgag 1200 gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc tgctccgagc gggccgggcc 1260 ccgctgtcgt cggcggggat tagctgcgag cattcccgct tcgagttgcg ggcggcgcgg 1320 gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc ggcttgaggc 1380 ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc cgcactctgg tctttttttt 1440 ttttgttgtt gttgccctgc tgccttcgat tgccgttcag caataggggc taacaaaggg 1500 agggtgcggg gcttgctcgc ccggagcccg gagaggtcat ggttggggag gaatggaggg 1560 acaggagtgg cggctggggc ccgcccgcct tcggagcaca tgtccgacgc cacctggatg 1620 gggcgaggcc tggggttttt cccgaagcaa ccaggctggg gttagcgtgc cgaggccatg 1680 tggccccagc acccggcacg atctggcttg gcggcgccgc gttgccctgc ctccctaact 1740 agggtgaggc catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc gctcccgggc 1800 cctgttgcaa ggagctcaaa atggaggacg cggcagcccg gtggagcggg cgggtgagtc 1860 acccacacaa aggaagaggg cctggtccct caccggctgc tgcttcctgt gaccccgtgg 1920 tcctatcggc cgcaatagtc acctcgggct tttgagcacg gctagtcgcg gcggggggag 1980 gggatgtaat ggcgttggag tttgttcaca tttggtgggt ggagactagt caggccagcc 2040 tggcgctgga agtcattttt ggaatttgtc cccttgagtt ttgagcggag ctaattctcg 2100 ggcttcttag cggttcaaag gtatctttta aacccttttt taggtgttgt gaaaaccacc 2160 gctaattcaa agcaagccgc cacc 2184 <210> 860 <211> 2848 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 860 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cgagacggac ggtagcatcc 960 ttaggatcga gtcaatggga aaaacccatt ggagccaagt acactgactc aatagggact 1020 ttccattggg ttttgcccag tacataaggt caataggggg tgagtcaaca ggaaagtccc 1080 attggagcca agtacattga gtcaataggg actttccaat gggttttgcc cagtacataa 1140 ggtcaatggg aggtaagcca atgggttttt cccattactg acatgtatac tgagtcatta 1200 gggactttcc aatgggtttt gcccagtaca taaggtcaat aggggtgaat caacaggaaa 1260 gtcccattgg agccaagtac actgagtcaa tagggacttt ccattgggtt ttgcccagta 1320 caaaaggtca atagggggtg agtcaatggg tttttcccat tattggcacg tacataaggt 1380 caataggggt gagtcattgg gtttttccag ccaatttata aaacgccatg tactttccca 1440 ccattgacgt caatgggcta ttgaaactaa tgcaacgtga cctttaaacg gtactttccc 1500 atagctgatt aatgggaaag taccgttctc gagccaatac acgtcaatgg gaagtgaaag 1560 ggcagccaaa acgtaacacc gccccggttt tcccctggaa attccatatt ggcacgcatt 1620 ctattggctg agctgcgttc tacgtgggta tataagcaga gctctcccta tcagtgatag 1680 agatctccct atcagtgata gagatcgtcg acgagctcag cgtcggtacc gtacctcttc 1740 cgcatcgctg tctgcgaggg ccagctgttg gggtgagtgg cgggtgtggc ttccgcgggc 1800 cccggagctg gagccctgct ctgagcgggc cgggctgata tgcgagtgtc gtccgcaggg 1860 tttagctgtg agcattccca cttcgagtgg cgggcggtgc gggggtgaga gtgcgaggcc 1920 tagcggcaac cccgtagcct cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgccg 1980 ccgcgtgcca ctccggccgc actatgcgtt ttttgtcctt gctgccctcg attgccttcc 2040 agcagcatgg gctaacaaag ggagggtgtg gggctcactc ttaaggagcc catgaagctt 2100 acgttggata ggaatggaag ggcaggaggg gcgactgggg cccgcccgcc ttcggagcac 2160 atgtccgacg ccacctggat ggggcgaggc ctgtggcttt ccgaagcaat cgggcgtgag 2220 tttagcctac ctgggccatg tggccctagc actgggcacg gtctggcctg gcggtgccgc 2280 gttcccttgc ctcccaacaa gggtgaggcc gtcccgcccg gcaccagttg cttgcgcgga 2340 aagatggccg ctcccggggc cctgttgcaa ggagctcaaa atggaggacg cggcagcccg 2400 gtggagcggg cgggtgagtc acccacacaa aggaagaggg ccttgcccct cgccggccgc 2460 tgcttcctgt gaccccgtgg tctatcggcc gcatagtcac ctcgggcttc tcttgagcac 2520 cgctcgtcgc ggcgggggga ggggatctaa tggcgttgga gtttgttcac atttggtggg 2580 tggagactag tcaggccagc ctggcgctgg aagtcattct tggaatttgc ccctttgagt 2640 ttggagcgag gctaattctc aagcctctta gcggttcaaa ggtattttct aaacccgttt 2700 ccagctcgcg gttgaggaca aactcttcgc ggtctttcca gtactcttgg atcggaaacc 2760 cgtcggcctc cgaacggtac tccgccaccg agggacctga gcgagtccgc atcgaccgga 2820 tcggaaaacc tcggcgccgc cacccacc 2848 <210> 861 <211> 3231 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 861 ccgcctagga cataacaggc ctattgattg gaaagtttgt caacgaattg tgggtctttt 60 ggggtttgct gcccctttta cgcaatgtgg atatcctgct ttaatgcctt tatatgcatg 120 tatacaagca aaacaggctt ttactttctc gccaacttac aaggcctttc tcagtaaaca 180 gtatatgacc ctttaccccg ttgctcggca acggcctggt ctgtgccaag tgtttgctga 240 cgcaaccccc actggttggg gcttggccat aggccatcag cgcatgcgtg gaacctttgt 300 gtctcctctg ccgatccata ctgcggaact cctagccgct tgttttgctc gcagctggac 360 tggagcaaac ctcatcggga ccgacaattc tgtcgtactc tcccgcaagt atacatcgtt 420 tccatggctg ctaggctgtg ctgccaactg gatcctgcgc gggacgtcct ttgtttacgt 480 cccgtcggcg ctgaatcccg cggacgaccc ctcccggggc cgcttggggc tctaccgccc 540 gcttctccgt ctgccgtacc gtccgaccac ggggcgcacc tctctttacg cggactcccc 600 gtctgtgcct tctcatctgc cggaccgtgt gcacttcgct tcacctctgc acgtcgcatg 660 gaggccaccg tgaacgccca ccggaacttg cccaaggtct tgcataagag gactcttgga 720 ctttcagcaa tgtcatcggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg 780 aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg 840 ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagtcccc 900 attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg 960 aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagaa atcgataata 1020 tatggtaggg ttcatagcca gagtaacctt tttttttaat ttttatttta ttttattttt 1080 gagtcgggcg cgccaaaatg aagtgaagtt cctatacttt ctagagcgag ctcacgggga 1140 cagccccccc ccaaagcccc cagggatgta attacgtccc tcccccgcta gggggcagca 1200 gcgagccgcc cggggctccg ctccggtccg gcgctccccc cgcatccccg agccggcagc 1260 gtgcggggac agcccgggca cggggaaggt ggcacgggat cgctttcctc tgaacgcttc 1320 tcgctgctct ttgagcctgc agacacctgg ggggatacgg ggaaaaagct ttaggctgaa 1380 agagagattt agaatgacag gcgagctcac ggggacagcc cccccccaaa gcccccaggg 1440 atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg 1500 gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg 1560 aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca 1620 cctgggggga tacggggaaa aagcttgaaa cttgatctgt cgccgcaatt caagcttcgt 1680 gaggctccgg tgcccgtcag tgacctgcta tactctggag acgcctctcc cggccagagg 1740 agcaaggtat gcgggaggcg accaggagga tagcggggct gacgtcggga ggtggcctcc 1800 gtgggaagga cacccggatc ttgacacagc cttggcagcg gagtcaggaa gagtaggggt 1860 aggttctgga cgccctcttg gccagctcat cgccgcccca ccctctgctg gagcacagag 1920 taattcatac aaaaggaggg atcgccttcg caaggggaga gcccagggac cgtccctaaa 1980 ttctcacaga cccaaatccc tgtagccgcc ccacgacagc gcgaggagca tgcgcccagg 2040 gctgagcgcg ggtagatcag agcacacaag ctcacagtcc ccggcggtgg ggggaggggc 2100 gcgctgagcg ggggccaggg agctggcgcg gggcaaactg ggaaagtggt gtcgtgtgct 2160 ggctccgccc tcttcccgag ggtgggggag aacggtatat aagtgcggta gtcgccttgg 2220 acgttctttt tcgcaacggg tttgccgtca gaacgcaggt gagtggcggg tgtggcttcc 2280 gcgggccccg gagctggagc cctgctctga gcgggccggg ctgatatgcg agtgtcgtcc 2340 gcagggttta gctgtgagca ttcccacttc gagtggcggg cggtgcgggg gtgagagtgc 2400 gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct agcgtggtgt 2460 ccgccgccgc gtgccactcc ggccgcacta tgcgtttttt gtccttgctg ccctcgattg 2520 ccttccagca gcatgggcta acaaagggag ggtgtggggc tcactcttaa ggagcccatg 2580 aagcttacgt tggataggaa tggaagggca ggaggggcga ctggggcccg cccgccttcg 2640 gagcacatgt ccgacgccac ctggatgggg cgaggcctgt ggctttccga agcaatcggg 2700 cgtgagttta gcctacctgg gccatgtggc cctagcactg ggcacggtct ggcctggcgg 2760 tgccgcgttc ccttgcctcc caacaagggt gaggccgtcc cgcccggcac cagttgcttg 2820 cgcggaaaga tggccgctcc cggggccctg ttgcaaggag ctcaaaatgg aggacgcggc 2880 agcccggtgg agcgggcggg tgagtcaccc acacaaagga agagggcctt gcccctcgcc 2940 ggccgctgct tcctgtgacc ccgtggtcta tcggccgcat agtcacctcg ggcttctctt 3000 gagcaccgct cgtcgcggcg gggggagggg atctaatggc gttggagttt gttcacattt 3060 ggtgggtgga gactagtcag gccagcctgg cgctggaagt cattcttgga atttgcccct 3120 ttgagtttgg agcgaggcta attctcaagc ctcttagcgg ttcaaaggta ttttctaaac 3180 ccgtttccag gtgttgtgaa agccaccgct aattcaaagc aagccgccac c 3231 <210> 862 <211> 3260 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 862 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggctt ggccataggc catcagcgca tgcgtggaac 300 ctttgtgtct cctctgccga tccatactgc ggaactccta gccgcttgtt ttgctcgcag 360 ctggactgga gcaaacctca tcgggaccga caattctgtc gtactctccc gcaagcactc 420 accgtttccg cggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcctcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgccc atgtatcttt ttcacctgtg ccttgttttt gcctgtgttc cgcgtcctac 660 ttttcaagcc tccaagctgt gccttgggcg gctttggggc atggacatag atccctataa 720 agaatttggt tcatcttatc agttgttgaa ttttcttcct ttggacgggg gaggctaact 780 gaaacacgga aggagacaat accggaagga acccgcgcta tgacggcaat aaaaagacag 840 aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc ggggttcggt cccagggctg 900 gcactctgtc gataccccac cgagtcccca ttggggccaa tacgcccgcg tttcttcctt 960 ttccccaccc caccccccaa gttcgggtga aggcccaggg ctcgcagcca acgtcggggc 1020 ggcaggccct gccatagaaa tcgataatat atggtagggt tcatagccag agtaaccttt 1080 ttttttaatt tttattttat tttatttttg agtcgggcgc gccaaaatga agtgaagttc 1140 ctatactttc tagagcgagc tcacggggac agcccccccc caaagccccc agggatgtaa 1200 ttacgtccct cccccgctag ggggcagcag cgagccgccc ggggctccgc tccggtccgg 1260 cgctcccccc gcatccccga gccggcagcg tgcggggaca gcccgggcac ggggaaggtg 1320 gcacgggatc gctttcctct gaacgcttct cgctgctctt tgagcctgca gacacctggg 1380 gggatacggg gaaaaagctt taggctgaaa gagagattta gaatgacagg cgagctcacg 1440 gggacagccc ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc 1500 agcagcgagc cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg 1560 cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg 1620 cttctcgctg ctctttgagc ctgcagacac ctggggggat acggggaaaa agcttgaaac 1680 ttgatctgtc gccgcaattc aagcttcgtg aggctccggt gcccgtcagt gacctgctat 1740 actctggaga cgcctctccc ggccagagga gcaaggtatg cgggaggcga ccaggaggat 1800 agcggggctg acgtcgggag gtggcctccg tgggaaggac acccggatct tgacacagcc 1860 ttggcagcgg agtcaggaag agtaggggta ggttctggac gccctcttgg ccagctcatc 1920 gccgccccac cctctgctgg agcacagagt aattcataca aaaggaggga tcgccttcgc 1980 aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct gtagccgccc 2040 cacgacagcg cgaggagcat gcgcccaggg ctgagcgcgg gtagatcaga gcacacaagc 2100 tcacagtccc cggcggtggg gggaggggcg cgctgagcgg gggccaggga gctggcgcgg 2160 ggcaaactgg gaaagtggtg tcgtgtgctg gctccgccct cttcccgagg gtgggggaga 2220 acggtatata agtgcggtag tcgccttgga cgttcttttt cgcaacgggt ttgccgtcag 2280 aacgcaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc ctgctctgag 2340 cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat tcccacttcg 2400 agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt agcctcgcct 2460 cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg gccgcactat 2520 gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa caaagggagg 2580 gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat ggaagggcag 2640 gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc tggatggggc 2700 gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg ccatgtggcc 2760 ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc aacaagggtg 2820 aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc ggggccctgt 2880 tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca 2940 cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc cgtggtctat 3000 cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg ggggagggga 3060 tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg ccagcctggc 3120 gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa ttctcaagcc 3180 tcttagcggt tcaaaggtat tttctaaacc cgtttccagg tgttgtgaaa gccaccgcta 3240 attcaaagca agccgccacc 3260 <210> 863 <211> 3106 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 863 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac 300 tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg 360 ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac 420 gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcgtctgc cccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgcct gtgggggagg ctaactgaaa cacggaagga gacaataccg gaaggaaccc 660 gcgctatgac ggcaataaaa agacagaata aaacgcacgg gtgttgggtc gtttgttcat 720 aaacgcgggg ttcggtccca gggctggcac tctgtcgata ccccaccgag tccccattgg 780 ggccaatacg cccgcgtttc ttccttttcc ccaccccacc ccccaagttc gggtgaaggc 840 ccagggctcg cagccaacgt cggggcggca ggccctgcca tagaaatcga taatatatgg 900 tagggttcat agccagagta accttttttt ttaattttta ttttatttta tttttgagtc 960 gggcgcgcca aaatgaagtg aagttcctat actttctaga gcgagctcac ggggacagcc 1020 cccccccaaa gcccccaggg atgtaattac gtccctcccc cgctaggggg cagcagcgag 1080 ccgcccgggg ctccgctccg gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg 1140 gggacagccc gggcacgggg aaggtggcac gggatcgctt tcctctgaac gcttctcgct 1200 gctctttgag cctgcagaca cctgggggga tacggggaaa aagctttagg ctgaaagaga 1260 gatttagaat gacaggcgag ctcacgggga cagccccccc ccaaagcccc cagggatgta 1320 attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg ctccggtccg 1380 gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca cggggaaggt 1440 ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc agacacctgg 1500 ggggatacgg ggaaaaagct tgaaacttga tctgtcgccg caattcaagc ttcgtgaggc 1560 tccggtgccc gtcagtgacc tgctatactc tggagacgcc tctcccggcc agaggagcaa 1620 ggtatgcggg aggcgaccag gaggatagcg gggctgacgt cgggaggtgg cctccgtggg 1680 aaggacaccc ggatcttgac acagccttgg cagcggagtc aggaagagta ggggtaggtt 1740 ctggacgccc tcttggccag ctcatcgccg ccccaccctc tgctggagca cagagtaatt 1800 catacaaaag gagggatcgc cttcgcaagg ggagagccca gggaccgtcc ctaaattctc 1860 acagacccaa atccctgtag ccgccccacg acagcgcgag gagcatgcgc ccagggctga 1920 gcgcgggtag atcagagcac acaagctcac agtccccggc ggtgggggga ggggcgcgct 1980 gagcgggggc cagggagctg gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc 2040 cgccctcttc ccgagggtgg gggagaacgg tatataagtg cggtagtcgc cttggacgtt 2100 ctttttcgca acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cttccgcggg 2160 ccccggagct ggagccctgc tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg 2220 gtttagctgt gagcattccc acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc 2280 ctagcggcaa ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc 2340 gccgcgtgcc actccggccg cactatgcgt tttttgtcct tgctgccctc gattgccttc 2400 cagcagcatg ggctaacaaa gggagggtgt ggggctcact cttaaggagc ccatgaagct 2460 tacgttggat aggaatggaa gggcaggagg ggcgactggg gcccgcccgc cttcggagca 2520 catgtccgac gccacctgga tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga 2580 gtttagccta cctgggccat gtggccctag cactgggcac ggtctggcct ggcggtgccg 2640 cgttcccttg cctcccaaca agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg 2700 aaagatggcc gctcccgggg ccctgttgca aggagctcaa aatggaggac gcggcagccc 2760 ggtggagcgg gcgggtgagt cacccacaca aaggaagagg gccttgcccc tcgccggccg 2820 ctgcttcctg tgaccccgtg gtctatcggc cgcatagtca cctcgggctt ctcttgagca 2880 ccgctcgtcg cggcgggggg aggggatcta atggcgttgg agtttgttca catttggtgg 2940 gtggagacta gtcaggccag cctggcgctg gaagtcattc ttggaatttg cccctttgag 3000 tttggagcga ggctaattct caagcctctt agcggttcaa aggtattttc taaacccgtt 3060 tccaggtgtt gtgaaagcca ccgctaattc aaagcaagcc gccacc 3106 <210> 864 <211> 3260 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 864 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac 300 tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg 360 ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac 420 gtcctttccg cggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcctcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgccc atgtatcttt ttcacctgtg ccttgttttt gcctgtgttc cgcgtcctac 660 ttttcaagcc tccaagctgt gccttgggcg gctttggggc atggacatag atccctataa 720 agaatttggt tcatcttatc agttgttgaa ttttcttcct ttggacgggg gaggctaact 780 gaaacacgga aggagacaat accggaagga acccgcgcta tgacggcaat aaaaagacag 840 aataaaacgc acgggtgttg ggtcgtttgt tcataaacgc ggggttcggt cccagggctg 900 gcactctgtc gataccccac cgagtcccca ttggggccaa tacgcccgcg tttcttcctt 960 ttccccaccc caccccccaa gttcgggtga aggcccaggg ctcgcagcca acgtcggggc 1020 ggcaggccct gccatagaaa tcgataatat atggtagggt tcatagccag agtaaccttt 1080 ttttttaatt tttattttat tttatttttg agtcgggcgc gccaaaatga agtgaagttc 1140 ctatactttc tagagcgagc tcacggggac agcccccccc caaagccccc agggatgtaa 1200 ttacgtccct cccccgctag ggggcagcag cgagccgccc ggggctccgc tccggtccgg 1260 cgctcccccc gcatccccga gccggcagcg tgcggggaca gcccgggcac ggggaaggtg 1320 gcacgggatc gctttcctct gaacgcttct cgctgctctt tgagcctgca gacacctggg 1380 gggatacggg gaaaaagctt taggctgaaa gagagattta gaatgacagg cgagctcacg 1440 gggacagccc ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc 1500 agcagcgagc cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg 1560 cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg 1620 cttctcgctg ctctttgagc ctgcagacac ctggggggat acggggaaaa agcttgaaac 1680 ttgatctgtc gccgcaattc aagcttcgtg aggctccggt gcccgtcagt gacctgctat 1740 actctggaga cgcctctccc ggccagagga gcaaggtatg cgggaggcga ccaggaggat 1800 agcggggctg acgtcgggag gtggcctccg tgggaaggac acccggatct tgacacagcc 1860 ttggcagcgg agtcaggaag agtaggggta ggttctggac gccctcttgg ccagctcatc 1920 gccgccccac cctctgctgg agcacagagt aattcataca aaaggaggga tcgccttcgc 1980 aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct gtagccgccc 2040 cacgacagcg cgaggagcat gcgcccaggg ctgagcgcgg gtagatcaga gcacacaagc 2100 tcacagtccc cggcggtggg gggaggggcg cgctgagcgg gggccaggga gctggcgcgg 2160 ggcaaactgg gaaagtggtg tcgtgtgctg gctccgccct cttcccgagg gtgggggaga 2220 acggtatata agtgcggtag tcgccttgga cgttcttttt cgcaacgggt ttgccgtcag 2280 aacgcaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc ctgctctgag 2340 cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat tcccacttcg 2400 agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt agcctcgcct 2460 cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg gccgcactat 2520 gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa caaagggagg 2580 gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat ggaagggcag 2640 gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc tggatggggc 2700 gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg ccatgtggcc 2760 ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc aacaagggtg 2820 aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc ggggccctgt 2880 tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca 2940 cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc cgtggtctat 3000 cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg ggggagggga 3060 tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg ccagcctggc 3120 gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa ttctcaagcc 3180 tcttagcggt tcaaaggtat tttctaaacc cgtttccagg tgttgtgaaa gccaccgcta 3240 attcaaagca agccgccacc 3260 <210> 865 <211> 3162 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 865 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggctt ggccataggc catcagcgca tgcgtggaac 300 ctttgtgtct cctctgccga tccatactgc ggaactccta gccgcttgtt ttgctcgcag 360 ctggactgga gcaaacctca tcgggaccga caattctgtc gtactctccc gcaagcactc 420 accgtttccg cggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcctcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgccc atgtatcttt ttcacctgtg ccttgttttt gcctgtgttc cgcgtcctac 660 ttttcaagcc tccaagctgt gccttgggcg gctttggggc atggacatag atccctataa 720 agaatttggt tcatcttatc agttgttgaa ttttcttcct ttggacatat tatccctaat 780 acttgccacc ccactcttaa tcagtggtgg aagaacggtg tcagaactgt ttgtttcaat 840 tggccattta agtttagtag taaaagactg gttaatgata acaatgcatc gtaaaacctt 900 cagaaggaaa ggagaatgtt ttgtggacca ctttggtttt cttttttgcg tgtggcagtt 960 ttaagttatt agtttttaaa atcagtactt tttaatggaa acaacttgac caaaaatttg 1020 tcacagaatt ttgagatcca ttaaaaaagt taaatgagaa acctgtgtgt tcctttggtc 1080 aacaccgaga catttaggtg aaagcatata ctgagattga gattaacttc ctgtgaaacc 1140 cagtgtctta gacaactgtg gcttgagcac cacctgttgg tattcattac aaacttgctc 1200 actacaataa atgaatttta agctttaaga tgaagtggca tttcttttaa cagttactat 1260 gttggaattg gttacaaatt ttggagtgga ctattgtata tatatatcag ttactgttat 1320 ggatcccacg tcactattgt atactctata ttatactcta tgttatactc tgtaatccta 1380 ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct cccgtgtctt gttatcacca 1440 tcaggtgaca tcctcgccca ggctgtcaat catgccggta tcgattccag tagcaccggc 1500 cccacgctga caacccactc ttgcagcgtt agcagcgccc ctcttaacaa gccgaccccc 1560 accagcgtcg cggttactaa cactcctctc cccggggcat ccgctactcc cgagctcgaa 1620 ttcgtttatc ggccaccgag gccaagatct ggccgccata tactgagtca ttagggactt 1680 tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg aaagtcccat 1740 tggagccaag tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg 1800 tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg 1860 ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc ccaccattga 1920 cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt cccatagctg 1980 attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga aagggcagcc 2040 aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc attctattgg 2100 ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaggg accggtttgc 2160 cgccagaaca caggtgaggg gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg 2220 ctccgagcgg gccgggcccc gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc 2280 gagttgcggg cggcgcggga ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc 2340 tcgtgtccgg cttgaggcct agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg 2400 cactctggtc tttttttttt ttgttgttgt tgccctgctg ccttcgattg ccgttcagca 2460 ataggggcta acaaagggag ggtgcggggc ttgctcgccc ggagcccgga gaggtcatgg 2520 ttggggagga atggagggac aggagtggcg gctggggccc gcccgccttc ggagcacatg 2580 tccgacgcca cctggatggg gcgaggcctg gggtttttcc cgaagcaacc aggctggggt 2640 tagcgtgccg aggccatgtg gccccagcac ccggcacgat ctggcttggc ggcgccgcgt 2700 tgccctgcct ccctaactag ggtgaggcca tcccgtccgg caccagttgc gtgcgtggaa 2760 agatggccgc tcccgggccc tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt 2820 ggagcgggcg ggtgagtcac ccacacaaag gaagagggcc tggtccctca ccggctgctg 2880 cttcctgtga ccccgtggtc ctatcggccg caatagtcac ctcgggcttt tgagcacggc 2940 tagtcgcggc ggggggaggg gatgtaatgg cgttggagtt tgttcacatt tggtgggtgg 3000 agactagtca ggccagcctg gcgctggaag tcatttttgg aatttgtccc cttgagtttt 3060 gagcggagct aattctcggg cttcttagcg gttcaaaggt atcttttaaa ccctttttta 3120 ggtgttgtga aaaccaccgc taattcaaag caagccgcca cc 3162 <210> 866 <211> 3008 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 866 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac 300 tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg 360 ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac 420 gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcgtctgc cccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgcct gtatattatc cctaatactt gccaccccac tcttaatcag tggtggaaga 660 acggtgtcag aactgtttgt ttcaattggc catttaagtt tagtagtaaa agactggtta 720 atgataacaa tgcatcgtaa aaccttcaga aggaaaggag aatgttttgt ggaccacttt 780 ggttttcttt tttgcgtgtg gcagttttaa gttattagtt tttaaaatca gtacttttta 840 atggaaacaa cttgaccaaa aatttgtcac agaattttga gatccattaa aaaagttaaa 900 tgagaaacct gtgtgttcct ttggtcaaca ccgagacatt taggtgaaag catatactga 960 gattgagatt aacttcctgt gaaacccagt gtcttagaca actgtggctt gagcaccacc 1020 tgttggtatt cattacaaac ttgctcacta caataaatga attttaagct ttaagatgaa 1080 gtggcatttc ttttaacagt tactatgttg gaattggtta caaattttgg agtggactat 1140 tgtatatata tatcagttac tgttatggat cccacgtcac tattgtatac tctatattat 1200 actctatgtt atactctgta atcctactca ataaacgtgt cacgcctgtg aaaccgtact 1260 aagtctcccg tgtcttgtta tcaccatcag gtgacatcct cgcccaggct gtcaatcatg 1320 ccggtatcga ttccagtagc accggcccca cgctgacaac ccactcttgc agcgttagca 1380 gcgcccctct taacaagccg acccccacca gcgtcgcggt tactaacact cctctccccg 1440 gggcatccgc tactcccgag ctcgaattcg tttatcggcc accgaggcca agatctggcc 1500 gccatatact gagtcattag ggactttcca atgggttttg cccagtacat aaggtcaata 1560 ggggtgaatc aacaggaaag tcccattgga gccaagtaca ctgagtcaat agggactttc 1620 cattgggttt tgcccagtac aaaaggtcaa tagggggtga gtcaatgggt ttttcccatt 1680 attggcacgt acataaggtc aataggggtg agtcattggg tttttccagc caatttataa 1740 aacgccatgt actttcccac cattgacgtc aatgggctat tgaaactaat gcaacgtgac 1800 ctttaaacgg tactttccca tagctgatta atgggaaagt accgttctcg agccaataca 1860 cgtcaatggg aagtgaaagg gcagccaaaa cgtaacaccg ccccggtttt cccctggaaa 1920 ttccatattg gcacgcattc tattggctga gctgcgttct acgtgggtat aagaggcgcg 1980 accagcgtcg gtagggaccg gtttgccgcc agaacacagg tgaggggcgg gtgtggcttc 2040 cgcgggccgc cgagctggag gtcctgctcc gagcgggccg ggccccgctg tcgtcggcgg 2100 ggattagctg cgagcattcc cgcttcgagt tgcgggcggc gcgggaggca gagtgcgagg 2160 cctagcggca accccgtagc ctcgcctcgt gtccggcttg aggcctagcg tggtgtccgc 2220 gccgccgccg cgtgctactc cggccgcact ctggtctttt ttttttttgt tgttgttgcc 2280 ctgctgcctt cgattgccgt tcagcaatag gggctaacaa agggagggtg cggggcttgc 2340 tcgcccggag cccggagagg tcatggttgg ggaggaatgg agggacagga gtggcggctg 2400 gggcccgccc gccttcggag cacatgtccg acgccacctg gatggggcga ggcctggggt 2460 ttttcccgaa gcaaccaggc tggggttagc gtgccgaggc catgtggccc cagcacccgg 2520 cacgatctgg cttggcggcg ccgcgttgcc ctgcctccct aactagggtg aggccatccc 2580 gtccggcacc agttgcgtgc gtggaaagat ggccgctccc gggccctgtt gcaaggagct 2640 caaaatggag gacgcggcag cccggtggag cgggcgggtg agtcacccac acaaaggaag 2700 agggcctggt ccctcaccgg ctgctgcttc ctgtgacccc gtggtcctat cggccgcaat 2760 agtcacctcg ggcttttgag cacggctagt cgcggcgggg ggaggggatg taatggcgtt 2820 ggagtttgtt cacatttggt gggtggagac tagtcaggcc agcctggcgc tggaagtcat 2880 ttttggaatt tgtccccttg agttttgagc ggagctaatt ctcgggcttc ttagcggttc 2940 aaaggtatct tttaaaccct tttttaggtg ttgtgaaaac caccgctaat tcaaagcaag 3000 ccgccacc 3008 <210> 867 <211> 3162 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 867 ccgcctagga cttcctgtta atcaacctct ggattacaaa atttgtgaaa gattgactgg 60 tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta 120 tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct 180 gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt 240 tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac 300 tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg 360 ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac 420 gtcctttccg cggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg 480 ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct 540 gcggcctctt ccgcctcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc 600 ctccccgccc atgtatcttt ttcacctgtg ccttgttttt gcctgtgttc cgcgtcctac 660 ttttcaagcc tccaagctgt gccttgggcg gctttggggc atggacatag atccctataa 720 agaatttggt tcatcttatc agttgttgaa ttttcttcct ttggacatat tatccctaat 780 acttgccacc ccactcttaa tcagtggtgg aagaacggtg tcagaactgt ttgtttcaat 840 tggccattta agtttagtag taaaagactg gttaatgata acaatgcatc gtaaaacctt 900 cagaaggaaa ggagaatgtt ttgtggacca ctttggtttt cttttttgcg tgtggcagtt 960 ttaagttatt agtttttaaa atcagtactt tttaatggaa acaacttgac caaaaatttg 1020 tcacagaatt ttgagatcca ttaaaaaagt taaatgagaa acctgtgtgt tcctttggtc 1080 aacaccgaga catttaggtg aaagcatata ctgagattga gattaacttc ctgtgaaacc 1140 cagtgtctta gacaactgtg gcttgagcac cacctgttgg tattcattac aaacttgctc 1200 actacaataa atgaatttta agctttaaga tgaagtggca tttcttttaa cagttactat 1260 gttggaattg gttacaaatt ttggagtgga ctattgtata tatatatcag ttactgttat 1320 ggatcccacg tcactattgt atactctata ttatactcta tgttatactc tgtaatccta 1380 ctcaataaac gtgtcacgcc tgtgaaaccg tactaagtct cccgtgtctt gttatcacca 1440 tcaggtgaca tcctcgccca ggctgtcaat catgccggta tcgattccag tagcaccggc 1500 cccacgctga caacccactc ttgcagcgtt agcagcgccc ctcttaacaa gccgaccccc 1560 accagcgtcg cggttactaa cactcctctc cccggggcat ccgctactcc cgagctcgaa 1620 ttcgtttatc ggccaccgag gccaagatct ggccgccata tactgagtca ttagggactt 1680 tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg aaagtcccat 1740 tggagccaag tacactgagt caatagggac tttccattgg gttttgccca gtacaaaagg 1800 tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa ggtcaatagg 1860 ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc ccaccattga 1920 cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt cccatagctg 1980 attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga aagggcagcc 2040 aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc attctattgg 2100 ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaggg accggtttgc 2160 cgccagaaca caggtgaggg gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg 2220 ctccgagcgg gccgggcccc gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc 2280 gagttgcggg cggcgcggga ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc 2340 tcgtgtccgg cttgaggcct agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg 2400 cactctggtc tttttttttt ttgttgttgt tgccctgctg ccttcgattg ccgttcagca 2460 ataggggcta acaaagggag ggtgcggggc ttgctcgccc ggagcccgga gaggtcatgg 2520 ttggggagga atggagggac aggagtggcg gctggggccc gcccgccttc ggagcacatg 2580 tccgacgcca cctggatggg gcgaggcctg gggtttttcc cgaagcaacc aggctggggt 2640 tagcgtgccg aggccatgtg gccccagcac ccggcacgat ctggcttggc ggcgccgcgt 2700 tgccctgcct ccctaactag ggtgaggcca tcccgtccgg caccagttgc gtgcgtggaa 2760 agatggccgc tcccgggccc tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt 2820 ggagcgggcg ggtgagtcac ccacacaaag gaagagggcc tggtccctca ccggctgctg 2880 cttcctgtga ccccgtggtc ctatcggccg caatagtcac ctcgggcttt tgagcacggc 2940 tagtcgcggc ggggggaggg gatgtaatgg cgttggagtt tgttcacatt tggtgggtgg 3000 agactagtca ggccagcctg gcgctggaag tcatttttgg aatttgtccc cttgagtttt 3060 gagcggagct aattctcggg cttcttagcg gttcaaaggt atcttttaaa ccctttttta 3120 ggtgttgtga aaaccaccgc taattcaaag caagccgcca cc 3162 <210> 868 <211> 1862 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 868 cttgctcacc tcgagtacga tagccggcta atcagccatg gctaataaag gaaatttatt 60 ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac atatgggagg 120 gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac atatgcccat 180 atgctggctg ccatgaacaa aggttggcta taaagaggtc atcagtatat gaaacagccc 240 cctgctgtcc attccttatt ccatagaaaa gccttgactt gaggttagat tttttttata 300 ttttgttttg tgttattttt ttctttaaca tccctaaaat tttccttaca tgttttacta 360 gccagatttt tcctcctctc ctgactactc ccagtcatag ctgtccctct tctcttatgg 420 agatctattc ggacggtgac gatatttgaa aatatggcat attgaaaatg tcgccgatgt 480 gagtttctgt gtaactgata tcgccatttt tccaaaagtg atttttgggc atacgcgata 540 tctggcgata gcgcttatat cgtttacggg ggatggcgat agacgacttt ggtgacttgg 600 gcgattctgt gtgtcgcaaa tatcgcagtt tcgatatagg tgacagacga tatgaggcta 660 tatcgccgat agaggcgaca tcaagctggc acatggccaa tgcatatcga tctatacatt 720 gaatcaatat tggccattag ccatattatt cattggttat atagcataaa tcaatattgg 780 ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg 840 tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac 900 ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg 960 cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc 1020 catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac 1080 tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa 1140 tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac 1200 ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta 1260 catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga 1320 cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa 1380 ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag 1440 agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca 1500 tagaagatac cgggaccgat ccagcctccg cggccgggaa cggtgcattg gaacgcggat 1560 tccccgtgcc aagagtgacc ctggcagaac tcggtaagtc tgttgacatg tatgtgatgt 1620 atactaacct gcatgggacg tggatttact tgtgtatgtc agatagagta aagattaact 1680 cttgcatgtg agcggggcat cgagatagcg ataaatgagt caggaggacg gagcctctgc 1740 taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt 1800 gctgtctcat cattttggca aagaatttca ccgtccttga cacgaagttt gctgccgcca 1860 cc 1862 <210> 869 <211> 1956 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 869 cttgctcacc tcgagtacga tagccggcta atcagccagc tggagcctcg gtagccgttc 60 ctcctgcccg ctgggcctcc caacgggccc tcctcccctc cttgcaccgg cccttcctgg 120 tctttgaata aatggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt 180 tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga 240 gtatttggtt tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg 300 gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag 360 aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt 420 aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact 480 actcccagtc atagctgtcc ctcttctctt atggagatct attcggacgg tgacgatatt 540 tgaaaatatg gcatattgaa aatgtcgccg atgtgagttt ctgtgtaact gatatcgcca 600 tttttccaaa agtgattttt gggcatacgc gatatctggc gatagcgctt atatcgttta 660 cgggggatgg cgatagacga ctttggtgac ttgggcgatt ctgtgtgtcg caaatatcgc 720 agtttcgata taggtgacag acgatatgag gctatatcgc cgatagaggc gacatcaagc 780 tggcacatgg ccaatgcata tcgatctata cattgaatca atattggcca ttagccatat 840 tattcattgg ttatatagca taaatcaata ttggctattg gccattgcat acgttgtatc 900 catatcataa tatgtacatt tatattggct catgtccaac attaccgcca tgttgacatt 960 gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata 1020 tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc 1080 cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc 1140 attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt 1200 atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt 1260 atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca 1320 tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg 1380 actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc 1440 aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg 1500 gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg 1560 cctggagacg ccatccacgc tgttttgacc tccatagaag ataccgggac cgatccagcc 1620 tccgcggccg ggaacggtgc attggaacgc ggattccccg tgccaagagt gaccctggca 1680 gaactcggta agtctgttga catgtatgtg atgtatacta acctgcatgg gacgtggatt 1740 tacttgtgta tgtcagatag agtaaagatt aactcttgca tgtgagcggg gcatcgagat 1800 agcgataaat gagtcaggag gacggagcct ctgctaacca tgttcatgcc ttcttctttt 1860 tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat 1920 ttcaccgtcc ttgacacgaa gtttgctgcc gccacc 1956 <210> 870 <211> 2541 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 870 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaaggggga ggctaactga aacacggaag 120 gagacaatac cggaaggaac ccgcgctatg acggcaataa aaagacagaa taaaacgcac 180 gggtgttggg tcgtttgttc ataaacgcgg ggttcggtcc cagggctggc actctgtcga 240 taccccaccg agtccccatt ggggccaata cgcccgcgtt tcttcctttt ccccacccca 300 ccccccaagt tcgggtgaag gcccagggct cgcagccaac gtcggggcgg caggccctgc 360 catagaaatc gataatatat ggtagggttc atagccagag taaccttttt ttttaatttt 420 tattttattt tatttttgag tcgggcgcgc caaaatgaag tgaagttcct atactttcta 480 gagcgagctc acggggacag ccccccccca aagcccccag ggatgtaatt acgtccctcc 540 cccgctaggg ggcagcagcg agccgcccgg ggctccgctc cggtccggcg ctccccccgc 600 atccccgagc cggcagcgtg cggggacagc ccgggcacgg ggaaggtggc acgggatcgc 660 tttcctctga acgcttctcg ctgctctttg agcctgcaga cacctggggg gatacgggga 720 aaaagcttta ggctgaaaga gagatttaga atgacaggcg agctcacggg gacagccccc 780 ccccaaagcc cccagggatg taattacgtc cctcccccgc tagggggcag cagcgagccg 840 cccggggctc cgctccggtc cggcgctccc cccgcatccc cgagccggca gcgtgcgggg 900 acagcccggg cacggggaag gtggcacggg atcgctttcc tctgaacgct tctcgctgct 960 ctttgagcct gcagacacct ggggggatac ggggaaaaag cttgaaactt gatctgtcgc 1020 cgcaattcaa gcttcgtgag gctccggtgc ccgtcagtga cctgctatac tctggagacg 1080 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 1140 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 1200 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 1260 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 1320 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 1380 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 1440 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 1500 cggcagtcgc cttggacgtt ctttttcgca acgggtttgc cgtcagaacg caggtgaggg 1560 gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg ctccgagcgg gccgggcccc 1620 gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc gagttgcggg cggcgcggga 1680 ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct 1740 agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg cactctggtc tttttttttt 1800 tgttgttgtt gccctgctgc cttcgattgc cgttcagcaa taggggctaa caaagggagg 1860 gtgcggggct tgctcgcccg gagcccggag aggtcatggt tggggaggaa tggagggaca 1920 ggagtggcgg ctggggcccg cccgccttcg gagcacatgt ccgacgccac ctggatgggg 1980 cgaggcctgg ggtttttccc gaagcaacca ggctggggtt agcgtgccga ggccatgtgg 2040 ccccagcacc cggcacgatc tggcttggcg gcgccgcgtt gccctgcctc cctaactagg 2100 gtgaggccat cccgtccggc accagttgcg tgcgtggaaa gatggccgct cccgggccct 2160 gttgcaagga gctcaaaatg gaggacgcgg cagcccggtg gagcgggcgg gtgagtcacc 2220 cacacaaagg aagagggcct ggtccctcac cggctgctgc ttcctgtgac cccgtggtcc 2280 tatcggccgc aatagtcacc tcgggctttt gagcacggct agtcgcggcg gggggagggg 2340 atgtaatggc gttggagttt gttcacattt ggtgggtgga gactagtcag gccagcctgg 2400 cgctggaagt catttttgga atttgtcccc ttgagttttg agcggagcta attctcgggc 2460 ttcttagcgg ttcaaaggta tcttttaaac ccttttttag gtgttgtgaa aaccaccgct 2520 aattcaaagc aagccgccac c 2541 <210> 871 <211> 2124 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 871 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaattcgt ttatcggcca ccgaggccaa gatctggccg 720 ccaacccgcc ccgaccggag ctgagagtaa ttcatacaaa aggactcgcc cctgccttgg 780 ggaatcccag ggaccgtcgt taaactccca ctaacgtaga acccagagat cgctgcgttc 840 ccgccccctc acccgcccgc tctcgtcatc actgaggtgg agaatagcat gcgtgaggct 900 ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag ttggggggag 960 gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg 1020 tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata agtgcagtag 1080 tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggta agtgccgtgt 1140 gtggttcccg cgggcctggc ctctttacgg gttatggccc ttgcgtgcct tgaattactt 1200 ccacctggct ccagtacgtg attcttgatc ccgagctgga gccaggggcg ggccttgcgc 1260 tttaggagcc ccttcgcctc gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg 1320 cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct ttcgataagt ctctagccat 1380 ttaaaatttt tgatgacgtg ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc 1440 gggccaggat ctgcacactg gtatttcggt ttttgggccc gcggccggcg acggggcccg 1500 tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg 1560 acgggggtag tctcaagctg gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat 1620 cgccccgccc tgggcggcaa ggctggcccg gtcggcacca gttgcgtgag cggaaagatg 1680 gccgcttccc ggccctgctc cagggggctc aaaatggagg acgcggcgct cgggagagcg 1740 ggcgggtgag tcacccacac aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg 1800 tgactccacg gagtaccggg cgccgtccag gcacctcgat tagttctgga gcttttggag 1860 tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg gagtttcccc acactgagtg 1920 ggtggagact gaagttaggc cagcttggca cttgatgtaa ttctccttgg aatttggcct 1980 ttttgagttt ggatcttggt tcattctcaa gcctcagaca gtggttcaaa gtttttttct 2040 tccatttcag gtgtcgtgaa aactaccagc ttgcttgttc tttttgcaga agctcagaat 2100 aaacgctcaa ctttggccgc cacc 2124 <210> 872 <211> 2768 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 872 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aatgaagtga agttcctata ctttctagag cgagctcacg 720 gggacagccc ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc 780 agcagcgagc cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg 840 cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg 900 cttctcgctg ctctttgagc ctgcagacac ctggggggat acggggaaaa agctttaggc 960 tgaaagagag atttagaatg acaggcgagc tcacggggac agcccccccc caaagccccc 1020 agggatgtaa ttacgtccct cccccgctag ggggcagcag cgagccgccc ggggctccgc 1080 tccggtccgg cgctcccccc gcatccccga gccggcagcg tgcggggaca gcccgggcac 1140 ggggaaggtg gcacgggatc gctttcctct gaacgcttct cgctgctctt tgagcctgca 1200 gacacctggg gggatacggg gaaaaagctt gaaacttgat ctgtcgccgc aattcaagct 1260 tcgtgaggct ccggtgcccg tcagtgacct gctatactct ggagacgagc ggggctgacg 1320 tcgggaggtg gcctccgtgg gaagggacac ccggatcttg acacagcctt ggcagcggag 1380 taaggaagag tagggataga ttctggccgc cctcttggcc agcttctcgc cgccccaccc 1440 tccgctaggg ccaagagtaa ttcatacaaa aggagggatc gccttcgcaa ggggagagcc 1500 cagggaccgt ccctaaattc tcacagaccc aaatccctgt agccgcccca cgacagcgcg 1560 aggagcatgc gctcagggct gagcgcgggg agagcagagc acacaagctc atagaccctg 1620 gtcgtggggg ggaggaccgg ggagctggcg cggggcaaac tgggaaagcg gtgtcgtgtg 1680 ctggctccgc cctcttcccg agggtggggg agaacggtat ataagtgcgg cagtcgcctt 1740 ggacgttctt tttcgcaacg ggtttgccgt cagaacgcag gtgaggggcg ggtgtggctt 1800 ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc gggccccgct gtcgtcggcg 1860 gggattagct gcgagcattc ccgcttcgag ttgcgggcgg cgcgggaggc agagtgcgag 1920 gcctagcggc aaccccgtag cctcgcctcg tgtccggctt gaggcctagc gtggtgtccg 1980 cgccgccgcc gcgtgctact ccggccgcac tctggtcttt ttttttttgt tgttgttgcc 2040 ctgctgcctt cgattgccgt tcagcaatag gggctaacaa agggagggtg cggggcttgc 2100 tcgcccggag cccggagagg tcatggttgg ggaggaatgg agggacagga gtggcggctg 2160 gggcccgccc gccttcggag cacatgtccg acgccacctg gatggggcga ggcctggggt 2220 ttttcccgaa gcaaccaggc tggggttagc gtgccgaggc catgtggccc cagcacccgg 2280 cacgatctgg cttggcggcg ccgcgttgcc ctgcctccct aactagggtg aggccatccc 2340 gtccggcacc agttgcgtgc gtggaaagat ggccgctccc gggccctgtt gcaaggagct 2400 caaaatggag gacgcggcag cccggtggag cgggcgggtg agtcacccac acaaaggaag 2460 agggcctggt ccctcaccgg ctgctgcttc ctgtgacccc gtggtcctat cggccgcaat 2520 agtcacctcg ggcttttgag cacggctagt cgcggcgggg ggaggggatg taatggcgtt 2580 ggagtttgtt cacatttggt gggtggagac tagtcaggcc agcctggcgc tggaagtcat 2640 ttttggaatt tgtccccttg agttttgagc ggagctaatt ctcgggcttc ttagcggttc 2700 aaaggtatct tttaaaccct tttttaggtg ttgtgaaaac caccgctaat tcaaagcaag 2760 ccgccacc 2768 <210> 873 <211> 2143 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 873 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaagcggggc tgacgtcggg aggtggcctc cgtgggaagg 720 gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg atagattctg 780 gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag agtaattcat 840 acaaaaggag ggatcgcctt cgcaagggga gagcccaggg accgtcccta aattctcaca 900 gacccaaatc cctgtagccg ccccacgaca gcgcgaggag catgcgctca gggctgagcg 960 cggggagagc agagcacaca agctcataga ccctggtcgt gggggggagg accggggagc 1020 tggcgcgggg caaactggga aagcggtgtc gtgtgctggc tccgccctct tcccgagggt 1080 gggggagaac ggtatataag tgcggcagtc gccttggacg ttctttttcg caacgggttt 1140 gccgtcagaa cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc 1200 tgctccgagc gggccgggcc ccgctgtcgt cggcggggat tagctgcgag cattcccgct 1260 tcgagttgcg ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg 1320 cctcgtgtcc ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc 1380 cgcactctgg tctttttttt tttgttgttg ttgccctgct gccttcgatt gccgttcagc 1440 aataggggct aacaaaggga gggtgcgggg cttgctcgcc cggagcccgg agaggtcatg 1500 gttggggagg aatggaggga caggagtggc ggctggggcc cgcccgcctt cggagcacat 1560 gtccgacgcc acctggatgg ggcgaggcct ggggtttttc ccgaagcaac caggctgggg 1620 ttagcgtgcc gaggccatgt ggccccagca cccggcacga tctggcttgg cggcgccgcg 1680 ttgccctgcc tccctaacta gggtgaggcc atcccgtccg gcaccagttg cgtgcgtgga 1740 aagatggccg ctcccgggcc ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg 1800 tggagcgggc gggtgagtca cccacacaaa ggaagagggc ctggtccctc accggctgct 1860 gcttcctgtg accccgtggt cctatcggcc gcaatagtca cctcgggctt ttgagcacgg 1920 ctagtcgcgg cggggggagg ggatgtaatg gcgttggagt ttgttcacat ttggtgggtg 1980 gagactagtc aggccagcct ggcgctggaa gtcatttttg gaatttgtcc ccttgagttt 2040 tgagcggagc taattctcgg gcttcttagc ggttcaaagg tatcttttaa accctttttt 2100 aggtgttgtg aaaaccaccg ctaattcaaa gcaagccgcc acc 2143 <210> 874 <211> 2209 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 874 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaag cggggctgac gtcgggaggt ggcctccgtg 780 ggaagggaca cccggatctt gacacagcct tggcagcgga gtaaggaaga gtagggatag 840 attctggccg ccctcttggc cagcttctcg ccgccccacc ctccgctagg gccaagagta 900 attcatacaa aaggagggat cgccttcgca aggggagagc ccagggaccg tccctaaatt 960 ctcacagacc caaatccctg tagccgcccc acgacagcgc gaggagcatg cgctcagggc 1020 tgagcgcggg gagagcagag cacacaagct catagaccct ggtcgtgggg gggaggaccg 1080 gggagctggc gcggggcaaa ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc 1140 gagggtgggg gagaacggta tataagtgcg gcagtcgcct tggacgttct ttttcgcaac 1200 gggtttgccg tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg 1260 aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt 1320 cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta 1380 gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac 1440 tccggccgca ctctggtctt tttttttttg ttgttgttgc cctgctgcct tcgattgccg 1500 ttcagcaata ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag 1560 gtcatggttg gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga 1620 gcacatgtcc gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg 1680 ctggggttag cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc 1740 gccgcgttgc cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg 1800 cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca 1860 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg 1920 gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga 1980 gcacggctag tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg 2040 tgggtggaga ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt 2100 gagttttgag cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc 2160 ttttttaggt gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 2209 <210> 875 <211> 2177 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 875 gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact 60 tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 120 tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt 180 tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga 240 ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg 300 acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta 360 aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc 420 atagctgtcc ctcttctctt atggagatca tattacccct aacacctgcc accccagtct 480 taatcagtgg tggaagaact ctcagaactg tttgtctcaa ttggccattt aagtttaata 540 gtgaaagact ggttaatgat aacaatgcat cggaaaacct tcaggaggaa aggagaatgt 600 tttgtggaac atttttgtgt gtgtggcagt tttaagttat tagttttcaa aatcagtact 660 ttttaatgga aacaacttga ccaaaaatct gtcacagaat tttgaaccca ttaaaaagcg 720 gggctgacgt cgggaggtgg cctccgtggg aagggacacc cggatcttga cacagccttg 780 gcagcggagt aaggaagagt agggatagat tctggccgcc ctcttggcca gcttctcgcc 840 gccccaccct ccgctagggc caagagtaat tcatacaaaa ggagggatcg ccttcgcaag 900 gggagagccc agggaccgtc cctaaattct cacagaccca aatccctgta gccgccccac 960 gacagcgcga ggagcatgcg ctcagggctg agcgcgggga gagcagagca cacaagctca 1020 tagaccctgg tcgtgggggg gaggaccggg gagctggcgc ggggcaaact gggaaagcgg 1080 tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata taagtgcggc 1140 agtcgccttg gacgttcttt ttcgcaacgg gtttgccgtc agaacgcagg tgaggggcgg 1200 gtgtggcttc cgcgggccgc cgagctggag gtcctgctcc gagcgggccg ggccccgctg 1260 tcgtcggcgg ggattagctg cgagcattcc cgcttcgagt tgcgggcggc gcgggaggca 1320 gagtgcgagg cctagcggca accccgtagc ctcgcctcgt gtccggcttg aggcctagcg 1380 tggtgtccgc gccgccgccg cgtgctactc cggccgcact ctggtctttt tttttttgtt 1440 gttgttgccc tgctgccttc gattgccgtt cagcaatagg ggctaacaaa gggagggtgc 1500 ggggcttgct cgcccggagc ccggagaggt catggttggg gaggaatgga gggacaggag 1560 tggcggctgg ggcccgcccg ccttcggagc acatgtccga cgccacctgg atggggcgag 1620 gcctggggtt tttcccgaag caaccaggct ggggttagcg tgccgaggcc atgtggcccc 1680 agcacccggc acgatctggc ttggcggcgc cgcgttgccc tgcctcccta actagggtga 1740 ggccatcccg tccggcacca gttgcgtgcg tggaaagatg gccgctcccg ggccctgttg 1800 caaggagctc aaaatggagg acgcggcagc ccggtggagc gggcgggtga gtcacccaca 1860 caaaggaaga gggcctggtc cctcaccggc tgctgcttcc tgtgaccccg tggtcctatc 1920 ggccgcaata gtcacctcgg gcttttgagc acggctagtc gcggcggggg gaggggatgt 1980 aatggcgttg gagtttgttc acatttggtg ggtggagact agtcaggcca gcctggcgct 2040 ggaagtcatt tttggaattt gtccccttga gttttgagcg gagctaattc tcgggcttct 2100 tagcggttca aaggtatctt ttaaaccctt ttttaggtgt tgtgaaaacc accgctaatt 2160 caaagcaagc cgccacc 2177 <210> 876 <211> 2007 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 876 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtctga gtgggcggca gcctgtgtgt 120 gcctgggttc tctctgtccc ggaatgtgcc aacaatggag gtgtttacct gtctcagacc 180 aaggacctct ctgcagctgc atggggctgg ggagggagaa ctgcagggag tatgggaggg 240 gaagctgagg tgggcctgct caagagaagg tgctgaacca tattacccct aacacctgcc 300 accccagtct taatcagtgg tggaagaact ctcagaactg tttgtctcaa ttggccattt 360 aagtttaata gtgaaagact ggttaatgat aacaatgcat cggaaaacct tcaggaggaa 420 aggagaatgt tttgtggaac atttttgtgt gtgtggcagt tttaagttat tagttttcaa 480 aatcagtact ttttaatgga aacaacttga ccaaaaatct gtcacagaat tttgaaccca 540 ttaaaaagcg gggctgacgt cgggaggtgg cctccgtggg aagggacacc cggatcttga 600 cacagccttg gcagcggagt aaggaagagt agggatagat tctggccgcc ctcttggcca 660 gcttctcgcc gccccaccct ccgctagggc caagagtaat tcatacaaaa ggagggatcg 720 ccttcgcaag gggagagccc agggaccgtc cctaaattct cacagaccca aatccctgta 780 gccgccccac gacagcgcga ggagcatgcg ctcagggctg agcgcgggga gagcagagca 840 cacaagctca tagaccctgg tcgtgggggg gaggaccggg gagctggcgc ggggcaaact 900 gggaaagcgg tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata 960 taagtgcggc agtcgccttg gacgttcttt ttcgcaacgg gtttgccgtc agaacgcagg 1020 tgaggggcgg gtgtggcttc cgcgggccgc cgagctggag gtcctgctcc gagcgggccg 1080 ggccccgctg tcgtcggcgg ggattagctg cgagcattcc cgcttcgagt tgcgggcggc 1140 gcgggaggca gagtgcgagg cctagcggca accccgtagc ctcgcctcgt gtccggcttg 1200 aggcctagcg tggtgtccgc gccgccgccg cgtgctactc cggccgcact ctggtctttt 1260 tttttttgtt gttgttgccc tgctgccttc gattgccgtt cagcaatagg ggctaacaaa 1320 gggagggtgc ggggcttgct cgcccggagc ccggagaggt catggttggg gaggaatgga 1380 gggacaggag tggcggctgg ggcccgcccg ccttcggagc acatgtccga cgccacctgg 1440 atggggcgag gcctggggtt tttcccgaag caaccaggct ggggttagcg tgccgaggcc 1500 atgtggcccc agcacccggc acgatctggc ttggcggcgc cgcgttgccc tgcctcccta 1560 actagggtga ggccatcccg tccggcacca gttgcgtgcg tggaaagatg gccgctcccg 1620 ggccctgttg caaggagctc aaaatggagg acgcggcagc ccggtggagc gggcgggtga 1680 gtcacccaca caaaggaaga gggcctggtc cctcaccggc tgctgcttcc tgtgaccccg 1740 tggtcctatc ggccgcaata gtcacctcgg gcttttgagc acggctagtc gcggcggggg 1800 gaggggatgt aatggcgttg gagtttgttc acatttggtg ggtggagact agtcaggcca 1860 gcctggcgct ggaagtcatt tttggaattt gtccccttga gttttgagcg gagctaattc 1920 tcgggcttct tagcggttca aaggtatctt ttaaaccctt ttttaggtgt tgtgaaaacc 1980 accgctaatt caaagcaagc cgccacc 2007 <210> 877 <211> 2495 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 877 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aataggctga aagagagatt tagaatgaca ggcgagctca 720 cggggacagc ccccccccaa agcccccagg gatgtaatta cgtccctccc ccgctagggg 780 gcagcagcga gccgcccggg gctccgctcc ggtccggcgc tccccccgca tccccgagcc 840 ggcagcgtgc ggggacagcc cgggcacggg gaaggtggca cgggatcgct ttcctctgaa 900 cgcttctcgc tgctctttga gcctgcagac acctgggggg atacggggaa aaagcttgaa 960 acttgatctg tcgccgcaat tcaagcttcg tgaggctccg gtgcccgtca gtgacctgct 1020 atactctgga gacgagcggg gctgacgtcg ggaggtggcc tccgtgggaa gggacacccg 1080 gatcttgaca cagccttggc agcggagtaa ggaagagtag ggatagattc tggccgccct 1140 cttggccagc ttctcgccgc cccaccctcc gctagggcca agagtaattc atacaaaagg 1200 agggatcgcc ttcgcaaggg gagagcccag ggaccgtccc taaattctca cagacccaaa 1260 tccctgtagc cgccccacga cagcgcgagg agcatgcgct cagggctgag cgcggggaga 1320 gcagagcaca caagctcata gaccctggtc gtggggggga ggaccgggga gctggcgcgg 1380 ggcaaactgg gaaagcggtg tcgtgtgctg gctccgccct cttcccgagg gtgggggaga 1440 acggtatata agtgcggcag tcgccttgga cgttcttttt cgcaacgggt ttgccgtcag 1500 aacgcaggtg aggggcgggt gtggcttccg cgggccgccg agctggaggt cctgctccga 1560 gcgggccggg ccccgctgtc gtcggcgggg attagctgcg agcattcccg cttcgagttg 1620 cgggcggcgc gggaggcaga gtgcgaggcc tagcggcaac cccgtagcct cgcctcgtgt 1680 ccggcttgag gcctagcgtg gtgtccgcgc cgccgccgcg tgctactccg gccgcactct 1740 ggtctttttt tttttgttgt tgttgccctg ctgccttcga ttgccgttca gcaatagggg 1800 ctaacaaagg gagggtgcgg ggcttgctcg cccggagccc ggagaggtca tggttgggga 1860 ggaatggagg gacaggagtg gcggctgggg cccgcccgcc ttcggagcac atgtccgacg 1920 ccacctggat ggggcgaggc ctggggtttt tcccgaagca accaggctgg ggttagcgtg 1980 ccgaggccat gtggccccag cacccggcac gatctggctt ggcggcgccg cgttgccctg 2040 cctccctaac tagggtgagg ccatcccgtc cggcaccagt tgcgtgcgtg gaaagatggc 2100 cgctcccggg ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg 2160 gcgggtgagt cacccacaca aaggaagagg gcctggtccc tcaccggctg ctgcttcctg 2220 tgaccccgtg gtcctatcgg ccgcaatagt cacctcgggc ttttgagcac ggctagtcgc 2280 ggcgggggga ggggatgtaa tggcgttgga gtttgttcac atttggtggg tggagactag 2340 tcaggccagc ctggcgctgg aagtcatttt tggaatttgt ccccttgagt tttgagcgga 2400 gctaattctc gggcttctta gcggttcaaa ggtatctttt aaaccctttt ttaggtgttg 2460 tgaaaaccac cgctaattca aagcaagccg ccacc 2495 <210> 878 <211> 1929 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 878 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaattcgt ttatcggcca ccgaggccaa gatctggccg 720 ccagcacatc gcccacagtc cccgagaagt tgggaggggt cggcaattga accggtgcct 780 agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc 840 ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca 900 acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct 960 ttacgggtta tggcccttgc gtgccttgaa ttacttccac ctggctccag tacgtgattc 1020 ttgatcccga gctggagcca ggggcgggcc ttgcgcttta ggagcccctt cgcctcgtgc 1080 ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg 1140 cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacgtgctgc 1200 gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caggatctgc acactggtat 1260 ttcggttttt gggcccgcgg ccggcgacgg ggcccgtgcg tcccagcgca catgttcggc 1320 gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg 1380 gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct 1440 ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctccagg 1500 gggctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag 1560 gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt accgggcgcc 1620 gtccaggcac ctcgattagt tctggagctt ttggagtacg tcgtctttag gttgggggga 1680 ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc 1740 ttggcacttg atgtaattct ccttggaatt tggccttttt gagtttggat cttggttcat 1800 tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgaacacc 1860 atctattgct tagcttcctt cttctttttc ctagaagctc agaataaacg ctcaactttg 1920 gccgccacc 1929 <210> 879 <211> 2529 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 879 atcgggggag gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga 60 cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg 120 gttcggtccc agggctggca ctctgtcgat accccaccga gtccccattg gggccaatac 180 gcccgcgttt cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc 240 gcagccaacg tcggggcggc aggccctgcc atagaaatcg ataatatatg gtagggttca 300 tagccagagt aacctttttt tttaattttt attttatttt atttttgagt cgggcgcgcc 360 aaaatgaagt gaagttccta tactttctag agcgagctca cggggacagc ccccccccaa 420 agcccccagg gatgtaatta cgtccctccc ccgctagggg gcagcagcga gccgcccggg 480 gctccgctcc ggtccggcgc tccccccgca tccccgagcc ggcagcgtgc ggggacagcc 540 cgggcacggg gaaggtggca cgggatcgct ttcctctgaa cgcttctcgc tgctctttga 600 gcctgcagac acctgggggg atacggggaa aaagctttag gctgaaagag agatttagaa 660 tgacaggcga gctcacgggg acagcccccc cccaaagccc ccagggatgt aattacgtcc 720 ctcccccgct agggggcagc agcgagccgc ccggggctcc gctccggtcc ggcgctcccc 780 ccgcatcccc gagccggcag cgtgcgggga cagcccgggc acggggaagg tggcacggga 840 tcgctttcct ctgaacgctt ctcgctgctc tttgagcctg cagacacctg gggggatacg 900 gggaaaaagc ttgaaacttg atctgtcgcc gcaattcaag cttcgtgagg ctccggtgcc 960 cgtcagtgac ctgctatact ctggagacga gcggggctga cgtcgggagg tggcctccgt 1020 gggaagggac acccggatct tgacacagcc ttggcagcgg agtaaggaag agtagggata 1080 gattctggcc gccctcttgg ccagcttctc gccgccccac cctccgctag ggccaagagt 1140 aattcataca aaaggaggga tcgccttcgc ctggggaagt cccagggacc gtcgctaaat 1200 tctcataacc cataatcccg gtacccgccc caccacagtg cgaggagcat gcgctcaggg 1260 ctgagcgcgg ggagagcaga gcacacaagc tcatagaccc tggtcgtggg gggaggggcg 1320 cactgagcgg gggggggggg ggtgatgggg gggaggaccg gggagctggc gcggggcaaa 1380 ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc gagggtgggg gagaacggta 1440 tataagtgcg gcagtcgcct tggacgttcc tttttcgcaa cgggtttgcc gtcagaacgc 1500 aggtgagggg cgggtgtggc ttccgcgggc cgccgagctg gaggtcctgc tccgagcggg 1560 ccgggccccg ctgtcgtcgg cggggattag ctgcgagcat tcccgcttcg agttgcgggc 1620 ggcgcgggag gcagagtgcg aggcctagcg gcaaccccgt agcctcgcct cgtgtccggc 1680 ttgaggccta gcgtggtgtc cgcgccgccg ccgcgtgcta ctccggccgc actctggtct 1740 tttttttttt tgttgttgtt gccctgctgc cttcgattgc cgttcagcaa taggggctaa 1800 caaagggagg gtgcggggct tgctcgcccg gagcccggag aggtcatggt tggggaggaa 1860 tggagggaca ggagtggcgg ctggggcccg cccgccttcg gagcacatgt ccgacgccac 1920 ctggatgggg cgaggcctgg ggtttttccc gaagcaacca ggctggggtt agcgtgccga 1980 ggccatgtgg ccccagcacc cggcacgatc tggcttggcg gcgccgcgtt gccctgcctc 2040 cctaactagg gtgaggccat cccgtccggc accagttgcg tgcgtggaaa gatggccgct 2100 cccgggccct gttgcaagga gctcaaaatg gaggacgcgg cagcccggtg gagcgggcgg 2160 gtgagtcacc cacacaaagg aagagggcct ggtccctcac cggctgctgc ttcctgtgac 2220 cccgtggtcc tatcggccgc aatagtcacc tcgggctttt gagcacggct agtcgcggcg 2280 gggggagggg atgtaatggc gttggagttt gttcacattt ggtgggtgga gactagtcag 2340 gccagcctgg cgctggaagt catttttgga atttgtcccc ttgagttttg agcggagcta 2400 attctcgggc ttcttagcgg ttcaaaggta tcttttaaac ccttttttag gtgttgtgaa 2460 aaccaccgct aaagcttgct tgttcttttt gcagaagctc agaataaacg ctcaactttg 2520 gccgccacc 2529 <210> 880 <211> 2494 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 880 aaatcggggg aggctaactg aaacacggaa ggagacaata ccggaaggaa cccgcgctat 60 gacggcaata aaaagacaga ataaaacgca cgggtgttgg gtcgtttgtt cataaacgcg 120 gggttcggtc ccagggctgg cactctgtcg ataccccacc gagtccccat tggggccaat 180 acgcccgcgt ttcttccttt tccccacccc accccccaag ttcgggtgaa ggcccagggc 240 tcgcagccaa cgtcggggcg gcaggccctg ccatagaaat cgataatata tggtagggtt 300 catagccaga gtaacctttt tttttaattt ttattttatt ttatttttga gtcgggcgcg 360 ccaaaatgaa gtgaagttcc tatactttct agagcgagct cacggggaca gccccccccc 420 aaagccccca gggatgtaat tacgtccctc ccccgctagg gggcagcagc gagccgcccg 480 gggctccgct ccggtccggc gctccccccg catccccgag ccggcagcgt gcggggacag 540 cccgggcacg gggaaggtgg cacgggatcg ctttcctctg aacgcttctc gctgctcttt 600 gagcctgcag acacctgggg ggatacgggg aaaaagcttt aggctgaaag agagatttag 660 aatgacaggc gagctcacgg ggacagcccc ccccccaaag cccccaggga tgtaattacg 720 tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg tccggcgctc 780 cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg 840 ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac ctggggggat 900 acggggaaaa agcttgaaac ttgatctgtc gccgcaattc aagcttcgtg aggctccggt 960 gcccgtcagt gacctgctat actctggaga cgagcggggc tgacgtcggg aggtggcctc 1020 cgtgggaagg gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg 1080 atagattctg gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag 1140 agtaattcat acaaaaggag ggatcgcctt cgcctgggga agtcccaggg accgtcgcta 1200 aattctcata acccataatc ccggtacccg ccccaccaca gtgcgaggag catgcgctca 1260 gggctgagcg cggggagagc agagcacaca agctcataga ccctggtcgt ggggggaggg 1320 gcgcactgag cggggggggg gggggtgatg ggggggagga ccggggagct ggcgcggggc 1380 aaactgggaa agcggtgtcg tgtgctggct ccgccctctt cccgagggtg ggggagaacg 1440 gtatataagt gcggcagtcg ccttggacgt tcctttttcg caacgggttt gccgtcagaa 1500 cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc tgctccgagc 1560 gggccgggcc ccgctgtcgt cggcggggat tagctgcgag cattcccgct tcgagttgcg 1620 ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc 1680 ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc cgcactctgg 1740 tctttttttt ttttgttgtt gttgccctgc tgccttcgat tgccgttcag caataggggc 1800 taacaaaggg agggtgcggg gcttgctcgc ccggagcccg gagaggtcat ggttggggag 1860 gaatggaggg acaggagtgg cggctggggc ccgcccgcct tcggagcaca tgtccgacgc 1920 cacctggatg gggcgaggcc tggggttttt cccgaagcaa ccaggctggg gttagcgtgc 1980 cgaggccatg tggccccagc acccggcacg atctggcttg gcggcgccgc gttgccctgc 2040 ctccctaact agggtgaggc catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc 2100 gctcccgggc cctgttgcaa ggagctcaaa atggaggacg cggcagcccg gtggagcggg 2160 cgggtgagtc acccacacaa aggaagaggg cctggtccct caccggctgc tgcttcctgt 2220 gaccccgtgg tcctatcggc cgcaatagtc acctcgggct tttgagcacg gctagtcgcg 2280 gcggggggag gggatgtaat ggcgttggag tttgttcaca tttggtgggt ggagactagt 2340 caggccagcc tggcgctgga agtcattttt ggaatttgtc cccttgagtt ttgagcggag 2400 ctaattctcg ggcttcttag cggttcaaag gtatctttta aacccttttt taggtgttgt 2460 gaaaaccacc gctaattcaa agcaagccgc cacc 2494 <210> 881 <211> 2905 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 881 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaaaatcgat aatatatggt agggttcata gccagagtaa 720 cctttttttt taatttttat tttattttat ttttgagtcg ggcgcgccaa aatgaagtga 780 agttcctata ctttctagag cgagctcacg gggacagccc ccccccaaag cccccaggga 840 tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg 900 tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga 960 aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac 1020 ctggggggat acggggaaaa agctttaggc tgaaagagag atttagaatg acaggcgagc 1080 tcacggggac agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag 1140 ggggcagcag cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga 1200 gccggcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct 1260 gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaagctt 1320 gaaacttgat ctgtcgccgc aattcaagct tcgtgaggct ccggtgcccg tcagtgacct 1380 gctatactct ggagacgcct ctcccggcca gaggagcaag gtatgcggga ggcgaccagg 1440 aggatagcgg ggctgacgtc gggaggtggc ctccgtggga aggacacccg gatcttgaca 1500 cagccttggc agcggagtca ggaagagtag gggtaggttc tggacgccct cttggccagc 1560 tcatcgccgc cccaccctct gctggagcac agagtaattc atacaaaagg agggatcgcc 1620 ttcgcaaggg gagagcccag ggaccgtccc taaattctca cagacccaaa tccctgtagc 1680 cgccccacga cagcgcgagg agcatgcgcc cagggctgag cgcgggtaga tcagagcaca 1740 caagctcaca gtccccggcg gtggggggag gggcgcgctg agcgggggcc agggagctgg 1800 cgcggggcaa actgggaaag tggtgtcgtg tgctggctcc gccctcttcc cgagggtggg 1860 ggagaacggt atataagtgc ggtagtcgcc ttggacgttc tttttcgcaa cgggtttgcc 1920 gtcagaacgc aggtgagtgg cgggtgtggc ttccgcgggc cccggagctg gagccctgct 1980 ctgagcgggc cgggctgata tgcgagtgtc gtccgcaggg tttagctgtg agcattccca 2040 cttcgagtgg cgggcggtgc gggggtgaga gtgcgaggcc tagcggcaac cccgtagcct 2100 cgcctcgtgt ccggcttgag gcctagcgtg gtgtccgccg ccgcgtgcca ctccggccgc 2160 actatgcgtt ttttgtcctt gctgccctcg attgccttcc agcagcatgg gctaacaaag 2220 ggagggtgtg gggctcactc ttaaggagcc catgaagctt acgttggata ggaatggaag 2280 ggcaggaggg gcgactgggg cccgcccgcc ttcggagcac atgtccgacg ccacctggat 2340 ggggcgaggc ctgtggcttt ccgaagcaat cgggcgtgag tttagcctac ctgggccatg 2400 tggccctagc actgggcacg gtctggcctg gcggtgccgc gttcccttgc ctcccaacaa 2460 gggtgaggcc gtcccgcccg gcaccagttg cttgcgcgga aagatggccg ctcccggggc 2520 cctgttgcaa ggagctcaaa atggaggacg cggcagcccg gtggagcggg cgggtgagtc 2580 acccacacaa aggaagaggg ccttgcccct cgccggccgc tgcttcctgt gaccccgtgg 2640 tctatcggcc gcatagtcac ctcgggcttc tcttgagcac cgctcgtcgc ggcgggggga 2700 ggggatctaa tggcgttgga gtttgttcac atttggtggg tggagactag tcaggccagc 2760 ctggcgctgg aagtcattct tggaatttgc ccctttgagt ttggagcgag gctaattctc 2820 aagcctctta gcggttcaaa ggtattttct aaacccgttt ccaggtgttg tgaaagccac 2880 cgctaattca aagcaagccg ccacc 2905 <210> 882 <211> 2937 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 882 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaaaatcgat aatatatggt agggttcata gccagagtaa 720 cctttttttt taatttttat tttattttat ttttgagtcg ggcgcgccaa aatgaagtga 780 agttcctata ctttctagag cgagctcacg gggacagccc ccccccaaag cccccaggga 840 tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg 900 tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga 960 aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac 1020 ctggggggat acggggaaaa agctttaggc tgaaagagag atttagaatg acaggcgagc 1080 tcacggggac agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag 1140 ggggcagcag cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga 1200 gccggcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct 1260 gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaagctt 1320 gaaacttgat ctgtcgccgc aattcaagct tcgtgaggct ccggtgcccg tcagtgacct 1380 gctatactct ggagacgagc ggggctgacg tcgggaggtg gcctccgtgg gaagggacac 1440 ccggatcttg acacagcctt ggcagcggag taaggaagag tagggataga ttctggccgc 1500 cctcttggcc agcttctcgc cgccccaccc tccgctaggg ccaagagtaa ttcatacaaa 1560 aggagggatc gccttcgcct ggggaagtcc cagggaccgt cgctaaattc tcataaccca 1620 taatcccggt acccgcccca ccacagtgcg aggagcatgc gctcagggct gagcgcgggg 1680 agagcagagc acacaagctc atagaccctg gtcgtggggg gaggggcgca ctgagcgggg 1740 gggggggggg tgatgggggg gaggaccggg gagctggcgc ggggcaaact gggaaagcgg 1800 tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata taagtgcggc 1860 agtcgccttg gacgttcctt tttcgcaacg ggtttgccgt cagaacgcag gtgaggggcg 1920 ggtgtggctt ccgcgggccg ccgagctgga ggtcctgctc cgagcgggcc gggccccgct 1980 gtcgtcggcg gggattagct gcgagcattc ccgcttcgag ttgcgggcgg cgcgggaggc 2040 agagtgcgag gcctagcggc aaccccgtag cctcgcctcg tgtccggctt gaggcctagc 2100 gtggtgtccg cgccgccgcc gcgtgctact ccggccgcac tctggtcttt tttttttttg 2160 ttgttgttgc cctgctgcct tcgattgccg ttcagcaata ggggctaaca aagggagggt 2220 gcggggcttg ctcgcccgga gcccggagag gtcatggttg gggaggaatg gagggacagg 2280 agtggcggct ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg 2340 aggcctgggg tttttcccga agcaaccagg ctggggttag cgtgccgagg ccatgtggcc 2400 ccagcacccg gcacgatctg gcttggcggc gccgcgttgc cctgcctccc taactagggt 2460 gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc cgggccctgt 2520 tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca 2580 cacaaaggaa gagggcctgg tccctcaccg gctgctgctt cctgtgaccc cgtggtccta 2640 tcggccgcaa tagtcacctc gggcttttga gcacggctag tcgcggcggg gggaggggat 2700 gtaatggcgt tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg 2760 ctggaagtca tttttggaat ttgtcccctt gagttttgag cggagctaat tctcgggctt 2820 cttagcggtt caaaggtatc ttttaaaccc ttttttaggt gttgtgaaaa ccaccgctaa 2880 agcttgcttg ttctttttgc agaagctcag aataaacgct caactttggc cgccacc 2937 <210> 883 <211> 2859 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 883 caccgaggga cctgagcgag tccgcatcga ccggatcgga aaacctctcg agaaaggcgt 60 ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc gggcggcagc gggtggcggt 120 cggggttgtt tctggcggag gtgctgctga tgatgtaatt aaagtaggcg gtcttgagag 180 ggcggatggt cgaggtgagg tgtggcaggc ttgagatcca gctgttgggg tgagtactcc 240 ctctcaaaag cgggcattac ttctgcgcta agattgtcag tttccaaaaa cgaggaggat 300 ttgatattca cctggcccga tctggccata cacttgagtg acaatgacat ccactttgcc 360 tttctctcca caggtgtcca ctcccaggtc caagtttaaa gccgccacca tcgggggagg 420 ctaactgaaa cacggaagga gacaataccg gaaggaaccc gcgctatgac ggcaataaaa 480 agacagaata aaacgcacgg gtgttgggtc gtttgttcat aaacgcgggg ttcggtccca 540 gggctggcac tctgtcgata ccccaccgag tccccattgg ggccaatacg cccgcgtttc 600 ttccttttcc ccaccccacc ccccaagttc gggtgaaggc ccagggctcg cagccaacgt 660 cggggcggca ggccctgcca tagaaatcga taatatatgg tagggttcat agccagagta 720 accttttttt ttaattttta ttttatttta tttttgagtc gggcgcgcca aaatgaagtg 780 aagttcctat actttctaga gcgagctcac ggggacagcc cccccccaaa gcccccaggg 840 atgtaattac gtccctcccc cgctaggggg cagcagcgag ccgcccgggg ctccgctccg 900 gtccggcgct ccccccgcat ccccgagccg gcagcgtgcg gggacagccc gggcacgggg 960 aaggtggcac gggatcgctt tcctctgaac gcttctcgct gctctttgag cctgcagaca 1020 cctgggggga tacggggaaa aagctttagg ctgaaagaga gatttagaat gacaggcgag 1080 ctcacgggga cagccccccc ccaaagcccc cagggatgta attacgtccc tcccccgcta 1140 gggggcagca gcgagccgcc cggggctccg ctccggtccg gcgctccccc cgcatccccg 1200 agccggcagc gtgcggggac agcccgggca cggggaaggt ggcacgggat cgctttcctc 1260 tgaacgcttc tcgctgctct ttgagcctgc agacacctgg ggggatacgg ggaaaaagct 1320 tgaaacttga tctgtcgccg caattcaagc ttcgtgaggc tccggtgccc gtcagtgacc 1380 tgctatactc tggagacgag cggggctgac gtcgggaggt ggcctccgtg ggaagggaca 1440 cccggatctt gacacagcct tggcagcgga gtaaggaaga gtagggatag attctggccg 1500 ccctcttggc cagcttctcg ccgccccacc ctccgctagg gccaagagta attcatacaa 1560 aaggagggat cgccttcgca aggggagagc ccagggaccg tccctaaatt ctcacagacc 1620 caaatccctg tagccgcccc acgacagcgc gaggagcatg cgctcagggc tgagcgcggg 1680 gagagcagag cacacaagct catagaccct ggtcgtgggg gggaggaccg gggagctggc 1740 gcggggcaaa ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc gagggtgggg 1800 gagaacggta tataagtgcg gcagtcgcct tggacgttct ttttcgcaac gggtttgccg 1860 tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg aggtcctgct 1920 ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt cccgcttcga 1980 gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta gcctcgcctc 2040 gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac tccggccgca 2100 ctctggtctt tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata 2160 ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg 2220 gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc 2280 gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag 2340 cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc 2400 cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga 2460 tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga 2520 gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt 2580 cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag 2640 tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga 2700 ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag 2760 cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttaggt 2820 gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 2859 <210> 884 <211> 2914 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 884 ccgcctagga ccaccgaggg acctgagcga gtccgcatcg accggatcgg aaaacctctc 60 gagaaaggcg tctaaccagt cacagtcgca aggtaggctg agcaccgtgg cgggcggcag 120 cgggtggcgg tcggggttgt ttctggcgga ggtgctgctg atgatgtaat taaagtaggc 180 ggtcttgaga gggcggatgg tcgaggtgag gtgtggcagg cttgagatcc agctgttggg 240 gtgagtactc cctctcaaaa gcgggcatta cttctgcgct aagattgtca gtttccaaaa 300 acgaggagga tttgatattc acctggcccg atctggccat acacttgagt gacaatgaca 360 tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaagtttaa agccgccacc 420 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 480 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 540 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 600 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 660 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 720 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 780 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 840 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 900 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 960 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 1020 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 1080 caggcgagct cacggggaca gccccccccc aaagccccca gggatgtaat tacgtccctc 1140 ccccgctagg gggcagcagc gagccgcccg gggctccgct ccggtccggc gctccccccg 1200 catccccgag ccggcagcgt gcggggacag cccgggcacg gggaaggtgg cacgggatcg 1260 ctttcctctg aacgcttctc gctgctcttt gagcctgcag acacctgggg ggatacgggg 1320 aaaaagcttg aaacttgatc tgtcgccgca attcaagctt cgtgaggctc cggtgcccgt 1380 cagtgacctg ctatactctg gagacgcctc tcccggccag aggagcaagg tatgcgggag 1440 gcgaccagga ggatagcggg gctgacgtcg ggaggtggcc tccgtgggaa ggacacccgg 1500 atcttgacac agccttggca gcggagtcag gaagagtagg ggtaggttct ggacgccctc 1560 ttggccagct catcgccgcc ccaccctctg ctggagcaca gagtaattca tacaaaagga 1620 gggatcgcct tcgcaagggg agagcccagg gaccgtccct aaattctcac agacccaaat 1680 ccctgtagcc gccccacgac agcgcgagga gcatgcgccc agggctgagc gcgggtagat 1740 cagagcacac aagctcacag tccccggcgg tggggggagg ggcgcgctga gcgggggcca 1800 gggagctggc gcggggcaaa ctgggaaagt ggtgtcgtgt gctggctccg ccctcttccc 1860 gagggtgggg gagaacggta tataagtgcg gtagtcgcct tggacgttct ttttcgcaac 1920 gggtttgccg tcagaacgca ggtgagtggc gggtgtggct tccgcgggcc ccggagctgg 1980 agccctgctc tgagcgggcc gggctgatat gcgagtgtcg tccgcagggt ttagctgtga 2040 gcattcccac ttcgagtggc gggcggtgcg ggggtgagag tgcgaggcct agcggcaacc 2100 ccgtagcctc gcctcgtgtc cggcttgagg cctagcgtgg tgtccgccgc cgcgtgccac 2160 tccggccgca ctatgcgttt tttgtccttg ctgccctcga ttgccttcca gcagcatggg 2220 ctaacaaagg gagggtgtgg ggctcactct taaggagccc atgaagctta cgttggatag 2280 gaatggaagg gcaggagggg cgactggggc ccgcccgcct tcggagcaca tgtccgacgc 2340 cacctggatg gggcgaggcc tgtggctttc cgaagcaatc gggcgtgagt ttagcctacc 2400 tgggccatgt ggccctagca ctgggcacgg tctggcctgg cggtgccgcg ttcccttgcc 2460 tcccaacaag ggtgaggccg tcccgcccgg caccagttgc ttgcgcggaa agatggccgc 2520 tcccggggcc ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg tggagcgggc 2580 gggtgagtca cccacacaaa ggaagagggc cttgcccctc gccggccgct gcttcctgtg 2640 accccgtggt ctatcggccg catagtcacc tcgggcttct cttgagcacc gctcgtcgcg 2700 gcggggggag gggatctaat ggcgttggag tttgttcaca tttggtgggt ggagactagt 2760 caggccagcc tggcgctgga agtcattctt ggaatttgcc cctttgagtt tggagcgagg 2820 ctaattctca agcctcttag cggttcaaag gtattttcta aacccgtttc caggtgttgt 2880 gaaagccacc gctaattcaa agcaagccgc cacc 2914 <210> 885 <211> 2527 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 885 caccgaggga cctgagcgag tccgcatcga ccggatcgga aaacctctcg agaaaggcgt 60 ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc gggcggcagc gggtggcggt 120 cggggttgtt tctggcggag gtgctgctga tgatgtaatt aaagtaggcg gtcttgagag 180 ggcggatggt cgaggtgagg tgtggcaggc ttgagatcca gctgttgggg tgagtactcc 240 ctctcaaaag cgggcattac ttctgcgcta agattgtcag tttccaaaaa cgaggaggat 300 ttgatattca cctggcccga tctggccata cacttgagtg acaatgacat ccactttgcc 360 tttctctcca caggtgtcca ctcccaggtc caagtttaaa gccgccaccg ggggaggcta 420 actgaaacac ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga 480 cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg 540 ctggcactct gtcgataccc caccgagtcc ccattggggc caatacgccc gcgtttcttc 600 cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag ccaacgtcgg 660 ggcggcaggc cctgccatag aaatcgataa tatatggtag ggttcatagc cagagtaacc 720 ttttttttta atttttattt tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag 780 ttcctatact ttctagagcg agctcacggg gacagccccc ccccaaagcc cccagggatg 840 taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc 900 cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag 960 gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct 1020 ggggggatac ggggaaaaag ctttaggctg aaagagagat ttagaatgac agagcggggc 1080 tgacgtcggg aggtggcctc cgtgggaagg gacacccgga tcttgacaca gccttggcag 1140 cggagtaagg aagagtaggg atagattctg gccgccctct tggccagctt ctcgccgccc 1200 caccctccgc tagggccaag agtaattcat acaaaaggag ggatcgcctt cgcaagggga 1260 gagcccaggg accgtcccta aattctcaca gacccaaatc cctgtagccg ccccacgaca 1320 gcgcgaggag catgcgctca gggctgagcg cggggagagc agagcacaca agctcataga 1380 ccctggtcgt gggggggagg accggggagc tggcgcgggg caaactggga aagcggtgtc 1440 gtgtgctggc tccgccctct tcccgagggt gggggagaac ggtatataag tgcggcagtc 1500 gccttggacg ttctttttcg caacgggttt gccgtcagaa cgcaggtgag gggcgggtgt 1560 ggcttccgcg ggccgccgag ctggaggtcc tgctccgagc gggccgggcc ccgctgtcgt 1620 cggcggggat tagctgcgag cattcccgct tcgagttgcg ggcggcgcgg gaggcagagt 1680 gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc ggcttgaggc ctagcgtggt 1740 gtccgcgccg ccgccgcgtg ctactccggc cgcactctgg tctttttttt ttttgttgtt 1800 gttgccctgc tgccttcgat tgccgttcag caataggggc taacaaaggg agggtgcggg 1860 gcttgctcgc ccggagcccg gagaggtcat ggttggggag gaatggaggg acaggagtgg 1920 cggctggggc ccgcccgcct tcggagcaca tgtccgacgc cacctggatg gggcgaggcc 1980 tggggttttt cccgaagcaa ccaggctggg gttagcgtgc cgaggccatg tggccccagc 2040 acccggcacg atctggcttg gcggcgccgc gttgccctgc ctccctaact agggtgaggc 2100 catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc gctcccgggc cctgttgcaa 2160 ggagctcaaa atggaggacg cggcagcccg gtggagcggg cgggtgagtc acccacacaa 2220 aggaagaggg cctggtccct caccggctgc tgcttcctgt gaccccgtgg tcctatcggc 2280 cgcaatagtc acctcgggct tttgagcacg gctagtcgcg gcggggggag gggatgtaat 2340 ggcgttggag tttgttcaca tttggtgggt ggagactagt caggccagcc tggcgctgga 2400 agtcattttt ggaatttgtc cccttgagtt ttgagcggag ctaattctcg ggcttcttag 2460 cggttcaaag gtatctttta aacccttttt taggtgttgt gaaaaccacc gctaattcaa 2520 agcaacc 2527 <210> 886 <211> 2747 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 886 ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca agagtgaccc tggcagaact 60 cggtaagtct gttgacatgt atgtgatgta tactaacctg catgggacgt ggatttactt 120 gtgtatgtca gatagagtaa agattaactc ttgcatgtga gcggggcatc gagatagcga 180 taaatgagtc aggaggacgg agcctctgct aaccatgttc atgccttctt ctttttccta 240 cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattcatc 300 gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg 360 caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt 420 cggtcccagg gctggcactc tgtcgatacc ccaccgagtc cccattgggg ccaatacgcc 480 cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca 540 gccaacgtcg gggcggcagg ccctgccata gaaatcgata atatatggta gggttcatag 600 ccagagtaac cttttttttt aatttttatt ttattttatt tttgagtcgg gcgcgccaaa 660 atgaagtgaa gttcctatac tttctagagc gagctcacgg ggacagcccc cccccaaagc 720 ccccagggat gtaattacgt ccctcccccg ctagggggca gcagcgagcc gcccggggct 780 ccgctccggt ccggcgctcc ccccgcatcc ccgagccggc agcgtgcggg gacagcccgg 840 gcacggggaa ggtggcacgg gatcgctttc ctctgaacgc ttctcgctgc tctttgagcc 900 tgcagacacc tggggggata cggggaaaaa gctttaggct gaaagagaga tttagaatga 960 caggcgagct cacggggaca gccccccccc aaagccccca gggatgtaat tacgtccctc 1020 ccccgctagg gggcagcagc gagccgcccg gggctccgct ccggtccggc gctccccccg 1080 catccccgag ccggcagcgt gcggggacag cccgggcacg gggaaggtgg cacgggatcg 1140 ctttcctctg aacgcttctc gctgctcttt gagcctgcag acacctgggg ggatacgggg 1200 aaaaagcttg aaacttgatc tgtcgccgca attcaagctt cgtgaggctc cggtgcccgt 1260 cagtgacctg ctatactctg gagacgagcg gggctgacgt cgggaggtgg cctccgtggg 1320 aagggacacc cggatcttga cacagccttg gcagcggagt aaggaagagt agggatagat 1380 tctggccgcc ctcttggcca gcttctcgcc gccccaccct ccgctagggc caagagtaat 1440 tcatacaaaa ggagggatcg ccttcgcaag gggagagccc agggaccgtc cctaaattct 1500 cacagaccca aatccctgta gccgccccac gacagcgcga ggagcatgcg ctcagggctg 1560 agcgcgggga gagcagagca cacaagctca tagaccctgg tcgtgggggg gaggaccggg 1620 gagctggcgc ggggcaaact gggaaagcgg tgtcgtgtgc tggctccgcc ctcttcccga 1680 gggtggggga gaacggtata taagtgcggc agtcgccttg gacgttcttt ttcgcaacgg 1740 gtttgccgtc agaacgcagg tgaggggcgg gtgtggcttc cgcgggccgc cgagctggag 1800 gtcctgctcc gagcgggccg ggccccgctg tcgtcggcgg ggattagctg cgagcattcc 1860 cgcttcgagt tgcgggcggc gcgggaggca gagtgcgagg cctagcggca accccgtagc 1920 ctcgcctcgt gtccggcttg aggcctagcg tggtgtccgc gccgccgccg cgtgctactc 1980 cggccgcact ctggtctttt tttttttgtt gttgttgccc tgctgccttc gattgccgtt 2040 cagcaatagg ggctaacaaa gggagggtgc ggggcttgct cgcccggagc ccggagaggt 2100 catggttggg gaggaatgga gggacaggag tggcggctgg ggcccgcccg ccttcggagc 2160 acatgtccga cgccacctgg atggggcgag gcctggggtt tttcccgaag caaccaggct 2220 ggggttagcg tgccgaggcc atgtggcccc agcacccggc acgatctggc ttggcggcgc 2280 cgcgttgccc tgcctcccta actagggtga ggccatcccg tccggcacca gttgcgtgcg 2340 tggaaagatg gccgctcccg ggccctgttg caaggagctc aaaatggagg acgcggcagc 2400 ccggtggagc gggcgggtga gtcacccaca caaaggaaga gggcctggtc cctcaccggc 2460 tgctgcttcc tgtgaccccg tggtcctatc ggccgcaata gtcacctcgg gcttttgagc 2520 acggctagtc gcggcggggg gaggggatgt aatggcgttg gagtttgttc acatttggtg 2580 ggtggagact agtcaggcca gcctggcgct ggaagtcatt tttggaattt gtccccttga 2640 gttttgagcg gagctaattc tcgggcttct tagcggttca aaggtatctt ttaaaccctt 2700 ttttaggtgt tgtgaaaacc accgctaatt caaagcaagc cgccacc 2747 <210> 887 <211> 2415 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 887 ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca agagtgaccc tggcagaact 60 cggtaagtct gttgacatgt atgtgatgta tactaacctg catgggacgt ggatttactt 120 gtgtatgtca gatagagtaa agattaactc ttgcatgtga gcggggcatc gagatagcga 180 taaatgagtc aggaggacgg agcctctgct aaccatgttc atgccttctt ctttttccta 240 cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattcggg 300 ggaggctaac tgaaacacgg aaggagacaa taccggaagg aacccgcgct atgacggcaa 360 taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg ttcataaacg cggggttcgg 420 tcccagggct ggcactctgt cgatacccca ccgagtcccc attggggcca atacgcccgc 480 gtttcttcct tttccccacc ccacccccca agttcgggtg aaggcccagg gctcgcagcc 540 aacgtcgggg cggcaggccc tgccatagaa atcgataata tatggtaggg ttcatagcca 600 gagtaacctt tttttttaat ttttatttta ttttattttt gagtcgggcg cgccaaaatg 660 aagtgaagtt cctatacttt ctagagcgag ctcacgggga cagccccccc ccaaagcccc 720 cagggatgta attacgtccc tcccccgcta gggggcagca gcgagccgcc cggggctccg 780 ctccggtccg gcgctccccc cgcatccccg agccggcagc gtgcggggac agcccgggca 840 cggggaaggt ggcacgggat cgctttcctc tgaacgcttc tcgctgctct ttgagcctgc 900 agacacctgg ggggatacgg ggaaaaagct ttaggctgaa agagagattt agaatgacag 960 agcggggctg acgtcgggag gtggcctccg tgggaaggga cacccggatc ttgacacagc 1020 cttggcagcg gagtaaggaa gagtagggat agattctggc cgccctcttg gccagcttct 1080 cgccgcccca ccctccgcta gggccaagag taattcatac aaaaggaggg atcgccttcg 1140 caaggggaga gcccagggac cgtccctaaa ttctcacaga cccaaatccc tgtagccgcc 1200 ccacgacagc gcgaggagca tgcgctcagg gctgagcgcg gggagagcag agcacacaag 1260 ctcatagacc ctggtcgtgg gggggaggac cggggagctg gcgcggggca aactgggaaa 1320 gcggtgtcgt gtgctggctc cgccctcttc ccgagggtgg gggagaacgg tatataagtg 1380 cggcagtcgc cttggacgtt ctttttcgca acgggtttgc cgtcagaacg caggtgaggg 1440 gcgggtgtgg cttccgcggg ccgccgagct ggaggtcctg ctccgagcgg gccgggcccc 1500 gctgtcgtcg gcggggatta gctgcgagca ttcccgcttc gagttgcggg cggcgcggga 1560 ggcagagtgc gaggcctagc ggcaaccccg tagcctcgcc tcgtgtccgg cttgaggcct 1620 agcgtggtgt ccgcgccgcc gccgcgtgct actccggccg cactctggtc tttttttttt 1680 ttgttgttgt tgccctgctg ccttcgattg ccgttcagca ataggggcta acaaagggag 1740 ggtgcggggc ttgctcgccc ggagcccgga gaggtcatgg ttggggagga atggagggac 1800 aggagtggcg gctggggccc gcccgccttc ggagcacatg tccgacgcca cctggatggg 1860 gcgaggcctg gggtttttcc cgaagcaacc aggctggggt tagcgtgccg aggccatgtg 1920 gccccagcac ccggcacgat ctggcttggc ggcgccgcgt tgccctgcct ccctaactag 1980 ggtgaggcca tcccgtccgg caccagttgc gtgcgtggaa agatggccgc tcccgggccc 2040 tgttgcaagg agctcaaaat ggaggacgcg gcagcccggt ggagcgggcg ggtgagtcac 2100 ccacacaaag gaagagggcc tggtccctca ccggctgctg cttcctgtga ccccgtggtc 2160 ctatcggccg caatagtcac ctcgggcttt tgagcacggc tagtcgcggc ggggggaggg 2220 gatgtaatgg cgttggagtt tgttcacatt tggtgggtgg agactagtca ggccagcctg 2280 gcgctggaag tcatttttgg aatttgtccc cttgagtttt gagcggagct aattctcggg 2340 cttcttagcg gttcaaaggt atcttttaaa ccctttttta ggtgttgtga aaaccaccgc 2400 taattcaaag caacc 2415 <210> 888 <211> 2802 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 888 ccgcctagga cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacc 60 ctggcagaac tcggtaagtc tgttgacatg tatgtgatgt atactaacct gcatgggacg 120 tggatttact tgtgtatgtc agatagagta aagattaact cttgcatgtg agcggggcat 180 cgagatagcg ataaatgagt caggaggacg gagcctctgc taaccatgtt catgccttct 240 tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca 300 aagaattcgg gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc 360 tatgacggca ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac 420 gcggggttcg gtcccagggc tggcactctg tcgatacccc accgagtccc cattggggcc 480 aatacgcccg cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag 540 ggctcgcagc caacgtcggg gcggcaggcc ctgccataga aatcgataat atatggtagg 600 gttcatagcc agagtaacct ttttttttaa tttttatttt attttatttt tgagtcgggc 660 gcgccaaaat gaagtgaagt tcctatactt tctagagcga gctcacgggg acagcccccc 720 cccaaagccc ccagggatgt aattacgtcc ctcccccgct agggggcagc agcgagccgc 780 ccggggctcc gctccggtcc ggcgctcccc ccgcatcccc gagccggcag cgtgcgggga 840 cagcccgggc acggggaagg tggcacggga tcgctttcct ctgaacgctt ctcgctgctc 900 tttgagcctg cagacacctg gggggatacg gggaaaaagc tttaggctga aagagagatt 960 tagaatgaca ggcgagctca cggggacagc ccccccccaa agcccccagg gatgtaatta 1020 cgtccctccc ccgctagggg gcagcagcga gccgcccggg gctccgctcc ggtccggcgc 1080 tccccccgca tccccgagcc ggcagcgtgc ggggacagcc cgggcacggg gaaggtggca 1140 cgggatcgct ttcctctgaa cgcttctcgc tgctctttga gcctgcagac acctgggggg 1200 atacggggaa aaagcttgaa acttgatctg tcgccgcaat tcaagcttcg tgaggctccg 1260 gtgcccgtca gtgacctgct atactctgga gacgcctctc ccggccagag gagcaaggta 1320 tgcgggaggc gaccaggagg atagcggggc tgacgtcggg aggtggcctc cgtgggaagg 1380 acacccggat cttgacacag ccttggcagc ggagtcagga agagtagggg taggttctgg 1440 acgccctctt ggccagctca tcgccgcccc accctctgct ggagcacaga gtaattcata 1500 caaaaggagg gatcgccttc gcaaggggag agcccaggga ccgtccctaa attctcacag 1560 acccaaatcc ctgtagccgc cccacgacag cgcgaggagc atgcgcccag ggctgagcgc 1620 gggtagatca gagcacacaa gctcacagtc cccggcggtg gggggagggg cgcgctgagc 1680 gggggccagg gagctggcgc ggggcaaact gggaaagtgg tgtcgtgtgc tggctccgcc 1740 ctcttcccga gggtggggga gaacggtata taagtgcggt agtcgccttg gacgttcttt 1800 ttcgcaacgg gtttgccgtc agaacgcagg tgagtggcgg gtgtggcttc cgcgggcccc 1860 ggagctggag ccctgctctg agcgggccgg gctgatatgc gagtgtcgtc cgcagggttt 1920 agctgtgagc attcccactt cgagtggcgg gcggtgcggg ggtgagagtg cgaggcctag 1980 cggcaacccc gtagcctcgc ctcgtgtccg gcttgaggcc tagcgtggtg tccgccgccg 2040 cgtgccactc cggccgcact atgcgttttt tgtccttgct gccctcgatt gccttccagc 2100 agcatgggct aacaaaggga gggtgtgggg ctcactctta aggagcccat gaagcttacg 2160 ttggatagga atggaagggc aggaggggcg actggggccc gcccgccttc ggagcacatg 2220 tccgacgcca cctggatggg gcgaggcctg tggctttccg aagcaatcgg gcgtgagttt 2280 agcctacctg ggccatgtgg ccctagcact gggcacggtc tggcctggcg gtgccgcgtt 2340 cccttgcctc ccaacaaggg tgaggccgtc ccgcccggca ccagttgctt gcgcggaaag 2400 atggccgctc ccggggccct gttgcaagga gctcaaaatg gaggacgcgg cagcccggtg 2460 gagcgggcgg gtgagtcacc cacacaaagg aagagggcct tgcccctcgc cggccgctgc 2520 ttcctgtgac cccgtggtct atcggccgca tagtcacctc gggcttctct tgagcaccgc 2580 tcgtcgcggc ggggggaggg gatctaatgg cgttggagtt tgttcacatt tggtgggtgg 2640 agactagtca ggccagcctg gcgctggaag tcattcttgg aatttgcccc tttgagtttg 2700 gagcgaggct aattctcaag cctcttagcg gttcaaaggt attttctaaa cccgtttcca 2760 ggtgttgtga aagccaccgc taattcaaag caagccgcca cc 2802 <210> 889 <211> 2399 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 889 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aataggctga aagagagatt tagaatgaca ggcgagctca 720 cggggacagc ccccccccaa agcccccagg gatgtaatta cgtccctccc ccgctagggg 780 gcagcagcga gccgcccggg gctccgctcc ggtccggcgc tccccccgca tccccgagcc 840 ggcagcgtgc ggggacagcc cgggcacggg gaaggtggca cgggatcgct ttcctctgaa 900 cgcttctcgc tgctctttga gcctgcagac acctgggggg atacggggaa aaagcttgaa 960 ttcgtttatc ggccaccgag gccaagatct ggccgccaac ccgccccgac cggagctgag 1020 agtaattcat acaaaaggac tcgcccctgc cttggggaat cccagggacc gtcgttaaac 1080 tcccactaac gtagaaccca gagatcgctg cgttcccgcc ccctcacccg cccgctctcg 1140 tcatcactga ggtggagaat agcatgcgtg aggctccggt gcccgtcagt gggcagagcg 1200 cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa cgggtgccta 1260 gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc 1320 cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa 1380 cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt 1440 tacgggttat ggcccttgcg tgccttgaat tacttccacc tggctccagt acgtgattct 1500 tgatcccgag ctggagccag gggcgggcct tgcgctttag gagccccttc gcctcgtgct 1560 tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc 1620 gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg acgtgctgcg 1680 acgctttttt tctggcaaga tagtcttgta aatgcgggcc aggatctgca cactggtatt 1740 tcggtttttg ggcccgcggc cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg 1800 aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg 1860 cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg 1920 gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctccaggg 1980 ggctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg 2040 aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg 2100 tccaggcacc tcgattagtt ctggagcttt tggagtacgt cgtctttagg ttggggggag 2160 gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct 2220 tggcacttga tgtaattctc cttggaattt ggcctttttg agtttggatc ttggttcatt 2280 ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaaaacta 2340 ccagcttgct tgttcttttt gcagaagctc agaataaacg ctcaactttg gccgccacc 2399 <210> 890 <211> 2872 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 890 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaaaatcgat aatatatggt agggttcata gccagagtaa 720 cctttttttt taatttttat tttattttat ttttgagtcg ggcgcgccaa aatgaagtga 780 agttcctata ctttctagag cgagctcacg gggacagccc ccccccaaag cccccaggga 840 tgtaattacg tccctccccc gctagggggc agcagcgagc cgcccggggc tccgctccgg 900 tccggcgctc cccccgcatc cccgagccgg cagcgtgcgg ggacagcccg ggcacgggga 960 aggtggcacg ggatcgcttt cctctgaacg cttctcgctg ctctttgagc ctgcagacac 1020 ctggggggat acggggaaaa agctttaggc tgaaagagag atttagaatg acaggcgagc 1080 tcacggggac agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag 1140 ggggcagcag cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga 1200 gccggcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct 1260 gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaagctt 1320 gaaacttgat ctgtcgccgc aattcaagct tcgtgaggct ccggtgcccg tcagtgacct 1380 gctatagaca agcaggggat ggcggggctg acgtcgggag gtggcctcca cgggaaggga 1440 cacccggatc tcgacacagc cttggcagtg gagtcaggaa gggtaggaca gattctggac 1500 gccctcttgg ccagtcctca ccgccccacc cccgatggag ccgagagtaa ttcatacaaa 1560 aggagggatc gccttcgccc ctgggaatcc cagggaccgt cgctaaattc tggccggcct 1620 cccagcccgg aaccgctgtg cccgcccagc gcggcgggag gagcctgcgc ctagggcgga 1680 tcgcgggtcg gcgggagagc acaagcccac agtccccggc ggtgggggag gggcgcgctg 1740 agcgggggcc cgggagccag cgcggggcaa actgggaaag tggtgtcgtg tgctggctcc 1800 gccctcttcc cgagggtggg ggagaacggt ataaaagtgc ggtagtcgcg ttggacgttc 1860 tttttcgcaa cgggtttgcc gtcagaacgc aggtgagtgg cgggtgtggc ctccgcgggc 1920 ccgggctccc tcctttgagc ggggtcggac cgccgtgcgg gtgtcgtcgg ccgggcttct 1980 ctgcgagcgt tcccgccctg gatggcgggc tgtgcgggag ggcgaggggg ggaggcctgg 2040 cggcggcccc ggagcctcgc ctcgtgtcgg gcgtgaggcc tagcgtggct tccgccccgc 2100 cgcgtgccac cgcggccgcg ctttgctgtc tgcccggctg ccctcgattg cctgcccgcg 2160 gcccgggcca acaaagggag ggcgtggagc tggctggtag ggagccccgt agtccgcatg 2220 tcgggcaggg agagcggcag cagtcggggg ggggaccggg cccgcccgtc ccgcagcaca 2280 tgtccgacgc cgcctggacg ggtagcggcc tgtgtcctga taaggcggcc gggcggtggg 2340 ttttagatgc cgggttcagg tggccccggg tcccggcccg gtctggccag taccccgtag 2400 tggcttagct ccgaggaggg cgagcccgcc cgcccggcac cagttgcgtg cgcggaaaga 2460 tggccgctcc cgggccctgt agcaaggagc tcaaaatgga ggacgcggca gcccggcgga 2520 gcggggcggg tgagtcaccc acacaaagga agagggcctt gcccctcgcc ggccgctgct 2580 tcctgtgacc ccgtggtgta ccggccgcac ttcagtcacc ccgggcgctc tttcggagca 2640 ccgctggcct ccgctggggg aggggatctg tctaatggcg ttggagtttg ctcacatttg 2700 gtgggtggag actgtagcca ggccagcctg gccatggaag taattcttgg aatttgccca 2760 ttttgagttt ggagcgaagc tgattgacaa agctgcttag ccgttcaaag gtattcttcg 2820 aacttttttt ttaaggtgtt gtgaaaacca ccgctaattc aaatccgcca cc 2872 <210> 891 <211> 2508 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 891 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaggtaattc gtagcatcct taggatcgag tcaatgggaa 720 aaacccattg gagccaagta cactgactca atagggactt tccattgggt tttgcccagt 780 acataaggtc aatagggggt gagtcaacag gaaagtccca ttggagccaa gtacattgag 840 tcaataggga ctttccaatg ggttttgccc agtacataag gtcaatggga ggtaagccaa 900 tgggtttttc ccattactga catgtatact gagtcattag ggactttcca atgggttttg 960 cccagtacat aaggtcaata ggggtgaatc aacaggaaag tcccattgga gccaagtaca 1020 ctgagtcaat agggactttc cattgggttt tgcccagtac aaaaggtcaa tagggggtga 1080 gtcaatgggt ttttcccatt attggcacat acataaggtc aataggggtg actagtaaat 1140 caacgggacc tcttcatcct cttcctcaat ctcgctttct ctctcgcttt tttttttttc 1200 ttcttctttt tttttttttt tttcaaaagg aggggagagg gggtaaaaaa atgctgcact 1260 gtgcggcgag gccggtgagt gagcgacgcg gagccaatca gcgcccgccg ttccgaaagt 1320 tgccttttat ggctcgagtg gccgctgtgg cgtcctataa aacccggcgg cgcaacgcgc 1380 agccactgtc gagtcgcgtc cacccgcgag cacagcttct ttgcagctcc ttcgttgccg 1440 gtccacaccc gccaccaggt aagcagggac gccgggccca gcgggccttc gctctctcgt 1500 ggctagtacc tcactgcagg gtcctgagga tcactcagaa cggacaccat gggcgggtgg 1560 agggtggtgc cgggccgcgg agcggacact ggcacagcca actttacgcc tagcgtgtag 1620 actctttgca gccacattcc cgcggtgtag acactcgtgg gcccgctccc gctcggtgcg 1680 tggggcttgg ggacacacta gggtcgcggt gtgggcattt gatgagccgg tgcggcttgc 1740 gggtgttaaa agccgtatta ggtccatctt gagagtacac agtattggga accagacgct 1800 acgatcacgc ctcaatggcc tctgggtctt tgtccaaacc ggtttgccta ttcggcttgc 1860 cgggcgggcg ggcgggcggg cgggcgcggc agggccggct cggccgggtg ggggctggga 1920 tgccactgcg cgtgcgctct ctatcactgg gcatcgaggc gcgtgtgcgc tagggaggga 1980 cctcttcctc tccccctctt cctagttagc tgcgcgtgcg tattgaggct gggagcgcgg 2040 ctgcccgggg ttgggcgagg gcggggccgt tgtccggaag gggcggggtc acagtggcac 2100 gggcgccttg tttgcgcttc ctgctgggtg tggtcgcctc ccgcgcgcgc acaagccgcc 2160 cgtcggcgca gtgtaggcgg agcttgcgcc cgtttgggga gggggcggag gtctggcttc 2220 ctgccctagg tccgcctccg ggccagcgtt tgccttttat ggtaataatg cggccggtct 2280 gcgcttcctt tgtcccctga gcttgggcgc gcgccccctg gcggctcgag cccgcggctt 2340 gccggaagtg ggcagggcgg cagcggctgc tcttggcggc cccgaggtga ctatagcctt 2400 cttttgtgtc ttgatagttc gccagcctct gctaaccatg ttcatgcctt cttctttttc 2460 ctacagctcc tgggcaacgt gctggttaat tcaaagcaag ccgccacc 2508 <210> 892 <211> 2477 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 892 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaggtaattc gtagcatcct taggatcgag tcaatgggaa 720 aaacccattg gagccaagta cactgactca atagggactt tccattgggt tttgcccagt 780 acataaggtc aatagggggt gagtcaacag gaaagtccca ttggagccaa gtacattgag 840 tcaataggga ctttccaatg ggttttgccc agtacataag gtcaatggga ggtaagccaa 900 tgggtttttc ccattactga catgtatact gagtcattag ggactttcca atgggttttg 960 cccagtacat aaggtcaata ggggtgaatc aacaggaaag tcccattgga gccaagtaca 1020 ctgagtcaat agggactttc cattgggttt tgcccagtac aaaaggtcaa tagggggtga 1080 gtcaatgggt ttttcccatt attggcacat acataaggtc aataggggtg actagtaaat 1140 caacgggaca cctcttcctc aactcacttc tctctactct cacttttttt tttcttcttc 1200 tttttttttt tttttttttt tttttttttt gcaaaagaag ggggtaaaaa aatgctgcac 1260 tgtcgggcga ggccggtgag tgagcgagcc ggagccaatc agcgcccgcc gttccgaaat 1320 tgccttttat ggctcgagtg gccgctgtgg cgtcctataa aacccggcgg cgcaacgcgc 1380 gccactgtcg agtccgcgtc cacccgcgag tacaacctcc ttgcagctcc tccgtcccgg 1440 tccacacccg ccaccaggta agcagggacg tcgggcccag cgggccccaa ctttaccttg 1500 gccactacct cgctgcagga tcgtgaggaa cactcagaag ggacaccgta gaggggtgga 1560 gcgtggtacc gggccgcgga gcagctggca aagcttaact ttcccggccc ctagggtgta 1620 gagtgtttgc agtcgtattc ccgcggtgtg gacactcgtg ggtacgctcc tgcttggtgc 1680 gcggggcttg gggacacact agagtcgcgg tgtgggcatt tggagagccg gtgcggctgc 1740 gggtgttaag ccgcatctgt ccaccttgag gggcaacagt attggggtca ggcgttacaa 1800 tcacgctttg atggcctatg ggtctttgtc caaaccggtt ttgccattcg gcttggcggg 1860 cgcggcgggg ccgctcggcc gggtgggggc tgggatgcca ttgcgcgtgc gcgctctatc 1920 actgggcatt ggggccgtgc gcgctgggga gggaactctt cctctccccc tcttccgagt 1980 taagagttgc gcgtgcgtat tgagactagg agcgcggccg ccccgggttg ggcgagggcg 2040 ggccgtccac cggaaggggc ggggtcgtag cggctaggcg cctgctcgcg cttcctgctg 2100 ggtgtggtcg cctcccgcgc gcgcactagc cgcccgtcgc ctcagtgtag gcgggcctgt 2160 gcccgtttgg ggaggggcgg aggcctggct tcctgccgtg ggtccgcctc cgggccagcg 2220 tttgcctttt atggtaataa tgcggctgtc ctgcgcttcc tttgtcccct gagcttgggc 2280 gcgcccctgg cggctcgagg ccgcggctcg ccggaagtgg gcagggcggc agcggctgct 2340 cttggcggct ccgcggtgac catagccctc ttttgtgcct tgatagttcg ccagcctctg 2400 ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg ctggttaatt 2460 caaagcaagc cgccacc 2477 <210> 893 <211> 2466 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 893 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaggtaattc gtagcatcct taggatcgag tcaatgggaa 720 aaacccattg gagccaagta cactgactca atagggactt tccattgggt tttgcccagt 780 acataaggtc aatagggggt gagtcaacag gaaagtccca ttggagccaa gtacattgag 840 tcaataggga ctttccaatg ggttttgccc agtacataag gtcaatggga ggtaagccaa 900 tgggtttttc ccattactga catgtatact gagtcattag ggactttcca atgggttttg 960 cccagtacat aaggtcaata ggggtgaatc aacaggaaag tcccattgga gccaagtaca 1020 ctgagtcaat agggactttc cattgggttt tgcccagtac aaaaggtcaa tagggggtga 1080 gtcaatgggt ttttcccatt attggcacat acataaggtc aataggggtg actagtaaat 1140 caacgggact ctctcttttt tttttttttt tttttttttt ttccaaaagg aggggagagg 1200 gggtaaaaaa atgctgcact gtgcggctag gccggtgagt gagcggcgcg gagccaatca 1260 gcgctcgccg ttccgaaagt tgccttttat ggctcgagtg gccgctgtgg cgtcctataa 1320 aacccggcgg cgcaacgcgc agccactgtc gagtccgcgt ccacccgcga gcacaggcct 1380 ttcgcagctc tttcttcgcc gctccacacc cgccaccagg taagcaggga caacaggccc 1440 agccggccac agccctcccg tgggcagtga ccgcgctgca gggtcgcggg ggacactcgg 1500 cgcggacacc ggggaaggct ggagggtggt gccgggccgc ggagcggaca ctttcagatc 1560 caactttcag tccagggtgt agacccttta cagccgcatt gccacggtgt agacaccggt 1620 ggacccgctc tggctcagag cacgcggctt gggggaaccc attagggtcg cagtgtgggc 1680 gctatgagag ccgatgcagc tttcgggtgt tgaaccgtat ctgcccacct tggggggagg 1740 acacaaggtc gggagccaaa cgccacgatc atgccttggt ggcccatggg tctttgtcta 1800 aaccggtttg cccatttggc ttgccgggcg ggcgggcgcg gcgggcccgg ctcggccggg 1860 tgggggctgg gttgccactg cgcttgcgcg ctctatggct gggtattggg gcgcgtgcac 1920 gctggggagg gagcccttcc tcttccccct ctcccaagtt aaacttgcgc gtgcgtattg 1980 agacttggag cgcggccacc ggggttgggc gagggcgggg ccgttgtccg gaaggggcgg 2040 ggtcgcagag gattcggggc gcctgctcgc gcttcctgct gggtgtggtc gcctcccgcg 2100 cgcgcactag accgcccggc gggggggcga aggcgggtct tgcgcccgtt tggggagggg 2160 gcggacacct ggcttcctgc cgtggggccg cctccggacc agcgtttgcc tcttatggta 2220 ataacgcggc cggcctgggc ttcatttgtc ccctgagttt gggcgcgcgc cccctggcgg 2280 cccgtgaccg cggcttgccg gaagtgggca gggcggcaac ggctgcgcct agtggcccgc 2340 cagtgaccgc gaccctcttt tgtgccctga tatagttcgc cagcctctgc taaccatgtt 2400 catgccttct tctttttcct acagctcctg ggcaacgtgc tggttaattc aaagcaagcc 2460 gccacc 2466 <210> 894 <211> 1728 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 894 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtttac ctgactcatg gtcctttcac 120 tttcacatgg gatttcccag ttatgaaatt aataaaaatc agtgatttcc acatctgtgt 180 gtgcctgtgc caggctgggt ggggaacagg aggccgagat gattccggga actgtcagaa 240 ggaataaaaa tcaatgattt ccacatcctg tctgtcttat gtcttggggg gtggggaggc 300 caggaagatt ccaggaaggt cagagtcaat aaaaatcaat ggtttccaca tctctcagtg 360 cctctatctg gaggccaggt agggctggcc ttgggggagg gggaggccag aatgactcca 420 agagctacag gaagggggga gggggaaaaa ggccagaata attccaggaa ccgccaagaa 480 ggaattcgtt tatcggccac cgaggccaag atctggccgc cagcacatcg cccacagtcc 540 ccgagaagtt gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa 600 actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 660 atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 720 aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt tacgggttat ggcccttgcg 780 tgccttgaat tacttccacc tggctccagt acgtgattct tgatcccgag ctggagccag 840 gggcgggcct tgcgctttag gagccccttc gcctcgtgct tgagttgagg cctggcctgg 900 gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga 960 taagtctcta gccatttaaa atttttgatg acgtgctgcg acgctttttt tctggcaaga 1020 tagtcttgta aatgcgggcc aggatctgca cactggtatt tcggtttttg ggcccgcggc 1080 cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg 1140 gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct 1200 cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc 1260 gtgagcggaa agatggccgc ttcccggccc tgctccaggg ggctcaaaat ggaggacgcg 1320 gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc 1380 agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt 1440 ctggagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt 1500 tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc 1560 cttggaattt ggcctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt 1620 tcaaagtttt tttcttccat ttcaggtgtc gtgaacacca tctattgctt agcttccttc 1680 ttctttttcc tagaagctca gaataaacgc tcaactttgg ccgccacc 1728 <210> 895 <211> 2053 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 895 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtttac ctgactcatg gtcctttcac 120 tttcacatgg gatttcccag ttatgaaatt aataaaaatc agtgatttcc acatctgtgt 180 gtgcctgtgc caggctgggt ggggaacagg aggccgagat gattccggga actgtcagaa 240 ggaataaaaa tcaatgattt ccacatcctg tctgtcttat gtcttggggg gtggggaggc 300 caggaagatt ccaggaaggt cagagtcaat aaaaatcaat ggtttccaca tctctcagtg 360 cctctatctg gaggccaggt agggctggcc ttgggggagg gggaggccag aatgactcca 420 agagctacag gaagggggga gggggaaaaa ggccagaata attccaggaa ccgccaagaa 480 ggaaacttga tctgtcgccg caattcaagc ttcgtgaggc tccggtgccc gtcagtgacc 540 tgctatactc tggagacgag cggggctgac gtcgggaggt ggcctccgtg ggaagggaca 600 cccggatctt gacacagcct tggcagcgga gtaaggaaga gtagggatag attctggccg 660 ccctcttggc cagcttctcg ccgccccacc ctccgctagg gccaagagta attcatacaa 720 aaggagggat cgccttcgca aggggagagc ccagggaccg tccctaaatt ctcacagacc 780 caaatccctg tagccgcccc acgacagcgc gaggagcatg cgctcagggc tgagcgcggg 840 gagagcagag cacacaagct catagaccct ggtcgtgggg gggaggaccg gggagctggc 900 gcggggcaaa ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc gagggtgggg 960 gagaacggta tataagtgcg gcagtcgcct tggacgttct ttttcgcaac gggtttgccg 1020 tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg aggtcctgct 1080 ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt cccgcttcga 1140 gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta gcctcgcctc 1200 gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac tccggccgca 1260 ctctggtctt tttttttttg ttgttgttgc cctgctgcct tcgattgccg ttcagcaata 1320 ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag gtcatggttg 1380 gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga gcacatgtcc 1440 gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg ctggggttag 1500 cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc gccgcgttgc 1560 cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg cgtggaaaga 1620 tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga 1680 gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg gctgctgctt 1740 cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga gcacggctag 1800 tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg tgggtggaga 1860 ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt gagttttgag 1920 cggagctaat tctcgggctt cttagcggtt caaaggtatc ttttaaaccc ttttttaggt 1980 gttgtgaaaa ccaccagctt ccttcttctt tttcctagaa gctcagaata aacgctcaac 2040 tttggccgcc acc 2053 <210> 896 <211> 2023 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 896 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtttac ctgactcatg gtcctttcac 120 tttcacatgg gatttcccag ttatgaaatt aataaaaatc agtgatttcc acatctgtgt 180 gtgcctgtgc caggctgggt ggggaacagg aggccgagat gattccggga actgtcagaa 240 ggaataaaaa tcaatgattt ccacatcctg tctgtcttat gtcttggggg gtggggaggc 300 caggaagatt ccaggaaggt cagagtcaat aaaaatcaat ggtttccaca tctctcagtg 360 cctctatctg gaggccaggt agggctggcc ttgggggagg gggaggccag aatgactcca 420 agagctacag gaagggggga gggggaaaaa ggccagaata attccaggaa ccgccaagaa 480 gcctctcccg gccagaggag caaggtatgc gggaggcgac caggaggata gcggggctga 540 cgtcgggagg tggcctccgt gggaaggaca cccggatctt gacacagcct tggcagcgga 600 gtcaggaaga gtaggggtag gttctggacg ccctcttggc cagctcatcg ccgccccacc 660 ctctgctgga gcacagagta attcatacaa aaggagggat cgccttcgca aggggagagc 720 ccagggaccg tccctaaatt ctcacagacc caaatccctg tagccgcccc acgacagcgc 780 gaggagcatg cgcccagggc tgagcgcggg tagatcagag cacacaagct cacagtcccc 840 ggcggtgggg ggaggggcgc gctgagcggg ggccagggag ctggcgcggg gcaaactggg 900 aaagtggtgt cgtgtgctgg ctccgccctc ttcccgaggg tgggggagaa cggtatataa 960 gtgcggtagt cgccttggac gttctttttc gcaacgggtt tgccgtcaga acgcaggtga 1020 gtggcgggtg tggcttccgc gggccccgga gctggagccc tgctctgagc gggccgggct 1080 gatatgcgag tgtcgtccgc agggtttagc tgtgagcatt cccacttcga gtggcgggcg 1140 gtgcgggggt gagagtgcga ggcctagcgg caaccccgta gcctcgcctc gtgtccggct 1200 tgaggcctag cgtggtgtcc gccgccgcgt gccactccgg ccgcactatg cgttttttgt 1260 ccttgctgcc ctcgattgcc ttccagcagc atgggctaac aaagggaggg tgtggggctc 1320 actcttaagg agcccatgaa gcttacgttg gataggaatg gaagggcagg aggggcgact 1380 ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg aggcctgtgg 1440 ctttccgaag caatcgggcg tgagtttagc ctacctgggc catgtggccc tagcactggg 1500 cacggtctgg cctggcggtg ccgcgttccc ttgcctccca acaagggtga ggccgtcccg 1560 cccggcacca gttgcttgcg cggaaagatg gccgctcccg gggccctgtt gcaaggagct 1620 caaaatggag gacgcggcag cccggtggag cgggcgggtg agtcacccac acaaaggaag 1680 agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtctatc ggccgcatag 1740 tcacctcggg cttctcttga gcaccgctcg tcgcggcggg gggaggggat ctaatggcgt 1800 tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg ctggaagtca 1860 ttcttggaat ttgccccttt gagtttggag cgaggctaat tctcaagcct cttagcggtt 1920 caaaggtatt ttctaaaccc gtttccaggt gttgtgaaaa ccaccagctt ccttcttctt 1980 tttcctagaa gctcagaata aacgctcaac tttggccgcc acc 2023 <210> 897 <211> 2071 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 897 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaagtttac ctgactcatg gtcctttcac 120 tttcacatgg gatttcccag ttatgaaatt aataaaaatc agtgatttcc acatctgtgt 180 gtgcctgtgc caggctgggt ggggaacagg aggccgagat gattccggga actgtcagaa 240 ggaataaaaa tcaatgattt ccacatcctg tctgtcttat gtcttggggg gtggggaggc 300 caggaagatt ccaggaaggt cagagtcaat aaaaatcaat ggtttccaca tctctcagtg 360 cctctatctg gaggccaggt agggctggcc ttgggggagg gggaggccag aatgactcca 420 agagctacag gaagggggga gggggaaaaa ggccagaata attccaggaa ccgccaagaa 480 ggaaacttga tctgtcgccg caattcaagc ttcgtgaggc tccggtgccc gtcagtgacc 540 tgctatagac aagcagggga tggcggggct gacgtcggga ggtggcctcc acgggaaggg 600 acacccggat ctcgacacag ccttggcagt ggagtcagga agggtaggac agattctgga 660 cgccctcttg gccagtcctc accgccccac ccccgatgga gccgagagta attcatacaa 720 aaggagggat cgccttcgcc cctgggaatc ccagggaccg tcgctaaatt ctggccggcc 780 tcccagcccg gaaccgctgt gcccgcccag cgcggcggga ggagcctgcg cctagggcgg 840 atcgcgggtc ggcgggagag cacaagccca cagtccccgg cggtggggga ggggcgcgct 900 gagcgggggc ccgggagcca gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc 960 cgccctcttc ccgagggtgg gggagaacgg tataaaagtg cggtagtcgc gttggacgtt 1020 ctttttcgca acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cctccgcggg 1080 cccgggctcc ctcctttgag cggggtcgga ccgccgtgcg ggtgtcgtcg gccgggcttc 1140 tctgcgagcg ttcccgccct ggatggcggg ctgtgcggga gggcgagggg gggaggcctg 1200 gcggcggccc cggagcctcg cctcgtgtcg ggcgtgaggc ctagcgtggc ttccgccccg 1260 ccgcgtgcca ccgcggccgc gctttgctgt ctgcccggct gccctcgatt gcctgcccgc 1320 ggcccgggcc aacaaaggga gggcgtggag ctggctggta gggagccccg tagtccgcat 1380 gtcgggcagg gagagcggca gcagtcgggg gggggaccgg gcccgcccgt cccgcagcac 1440 atgtccgacg ccgcctggac gggtagcggc ctgtgtcctg ataaggcggc cgggcggtgg 1500 gttttagatg ccgggttcag gtggccccgg gtcccggccc ggtctggcca gtaccccgta 1560 gtggcttagc tccgaggagg gcgagcccgc ccgcccggca ccagttgcgt gcgcggaaag 1620 atggccgctc ccgggccctg tagcaaggag ctcaaaatgg aggacgcggc agcccggcgg 1680 agcggggcgg gtgagtcacc cacacaaagg aagagggcct tgcccctcgc cggccgctgc 1740 ttcctgtgac cccgtggtgt accggccgca cttcagtcac cccgggcgct ctttcggagc 1800 accgctggcc tccgctgggg gaggggatct gtctaatggc gttggagttt gctcacattt 1860 ggtgggtgga gactgtagcc aggccagcct ggccatggaa gtaattcttg gaatttgccc 1920 attttgagtt tggagcgaag ctgattgaca aagctgctta gccgttcaaa ggtattcttc 1980 gaactttttt tttaaggtgt tgtgaaaacc accagcttcc ttcttctttt tcctagaagc 2040 tcagaataaa cgctcaactt tggccgccac c 2071 <210> 898 <211> 2290 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 898 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaacc tctcccggcc agaggagcaa ggtatgcggg 780 aggcgaccag gaggatagcg gggctgacgt cgggaggtgg cctccgtggg aaggacaccc 840 ggatcttgac acagccttgg cagcggagtc aggaagagta ggggtaggtt ctggacgccc 900 tcttggccag ctcatcgccg ccccaccctc tgctggagca cagagtaatt catacaaaag 960 gagggatcgc cttcgcaagg ggagagccca gggaccgtcc ctaaattctc acagacccaa 1020 atccctgtag ccgccccacg acagcgcgag gagcatgcgc ccagggctga gcgcgggtag 1080 atcagagcac acaagctcac agtccccggc ggtgggggga ggggcgcgct gagcgggggc 1140 cagggagctg gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc cgccctcttc 1200 ccgagggtgg gggagaacgg tatataagtg cggtagtcgc cttggacgtt ctttttcgca 1260 acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cttccgcggg ccccggagct 1320 ggagccctgc tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg gtttagctgt 1380 gagcattccc acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc ctagcggcaa 1440 ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc gccgcgtgcc 1500 actccggccg cactatgcgt tttttgtcct tgctgccctc gattgccttc cagcagcatg 1560 ggctaacaaa gggagggtgt ggggctcact cttaaggagc ccatgaagct tacgttggat 1620 aggaatggaa gggcaggagg ggcgactggg gcccgcccgc cttcggagca catgtccgac 1680 gccacctgga tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga gtttagccta 1740 cctgggccat gtggccctag cactgggcac ggtctggcct ggcggtgccg cgttcccttg 1800 cctcccaaca agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg aaagatggcc 1860 gctcccgggg ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg 1920 gcgggtgagt cacccacaca aaggaagagg gccttgcccc tcgccggccg ctgcttcctg 1980 tgaccccgtg gtctatcggc cgcatagtca cctcgggctt ctcttgagca ccgctcgtcg 2040 cggcgggggg aggggatcta atggcgttgg agtttgttca catttggtgg gtggagacta 2100 gtcaggccag cctggcgctg gaagtcattc ttggaatttg cccctttgag tttggagcga 2160 ggctaattct caagcctctt agcggttcaa aggtattttc taaacccgtt tccaggtgtt 2220 gtgaaaacca ccagcttcct tcttcttttt cctagaagct cagaataaac gctcaacttt 2280 ggccgccacc 2290 <210> 899 <211> 2224 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 899 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aacctctccc ggccagagga gcaaggtatg cgggaggcga 720 ccaggaggat agcggggctg acgtcgggag gtggcctccg tgggaaggac acccggatct 780 tgacacagcc ttggcagcgg agtcaggaag agtaggggta ggttctggac gccctcttgg 840 ccagctcatc gccgccccac cctctgctgg agcacagagt aattcataca aaaggaggga 900 tcgccttcgc aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct 960 gtagccgccc cacgacagcg cgaggagcat gcgcccaggg ctgagcgcgg gtagatcaga 1020 gcacacaagc tcacagtccc cggcggtggg gggaggggcg cgctgagcgg gggccaggga 1080 gctggcgcgg ggcaaactgg gaaagtggtg tcgtgtgctg gctccgccct cttcccgagg 1140 gtgggggaga acggtatata agtgcggtag tcgccttgga cgttcttttt cgcaacgggt 1200 ttgccgtcag aacgcaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc 1260 ctgctctgag cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat 1320 tcccacttcg agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt 1380 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg 1440 gccgcactat gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa 1500 caaagggagg gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat 1560 ggaagggcag gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc 1620 tggatggggc gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg 1680 ccatgtggcc ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc 1740 aacaagggtg aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc 1800 ggggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt 1860 gagtcaccca cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc 1920 cgtggtctat cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg 1980 ggggagggga tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg 2040 ccagcctggc gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa 2100 ttctcaagcc tcttagcggt tcaaaggtat tttctaaacc cgtttccagg tgttgtgaaa 2160 accaccagct tccttcttct ttttcctaga agctcagaat aaacgctcaa ctttggccgc 2220 cacc 2224 <210> 900 <211> 2272 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 900 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaaacttg atctgtcgcc gcaattcaag cttcgtgagg 720 ctccggtgcc cgtcagtgac ctgctataga caagcagggg atggcggggc tgacgtcggg 780 aggtggcctc cacgggaagg gacacccgga tctcgacaca gccttggcag tggagtcagg 840 aagggtagga cagattctgg acgccctctt ggccagtcct caccgcccca cccccgatgg 900 agccgagagt aattcataca aaaggaggga tcgccttcgc ccctgggaat cccagggacc 960 gtcgctaaat tctggccggc ctcccagccc ggaaccgctg tgcccgccca gcgcggcggg 1020 aggagcctgc gcctagggcg gatcgcgggt cggcgggaga gcacaagccc acagtccccg 1080 gcggtggggg aggggcgcgc tgagcggggg cccgggagcc agcgcggggc aaactgggaa 1140 agtggtgtcg tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtataaaagt 1200 gcggtagtcg cgttggacgt tctttttcgc aacgggtttg ccgtcagaac gcaggtgagt 1260 ggcgggtgtg gcctccgcgg gcccgggctc cctcctttga gcggggtcgg accgccgtgc 1320 gggtgtcgtc ggccgggctt ctctgcgagc gttcccgccc tggatggcgg gctgtgcggg 1380 agggcgaggg ggggaggcct ggcggcggcc ccggagcctc gcctcgtgtc gggcgtgagg 1440 cctagcgtgg cttccgcccc gccgcgtgcc accgcggccg cgctttgctg tctgcccggc 1500 tgccctcgat tgcctgcccg cggcccgggc caacaaaggg agggcgtgga gctggctggt 1560 agggagcccc gtagtccgca tgtcgggcag ggagagcggc agcagtcggg ggggggaccg 1620 ggcccgcccg tcccgcagca catgtccgac gccgcctgga cgggtagcgg cctgtgtcct 1680 gataaggcgg ccgggcggtg ggttttagat gccgggttca ggtggccccg ggtcccggcc 1740 cggtctggcc agtaccccgt agtggcttag ctccgaggag ggcgagcccg cccgcccggc 1800 accagttgcg tgcgcggaaa gatggccgct cccgggccct gtagcaagga gctcaaaatg 1860 gaggacgcgg cagcccggcg gagcggggcg ggtgagtcac ccacacaaag gaagagggcc 1920 ttgcccctcg ccggccgctg cttcctgtga ccccgtggtg taccggccgc acttcagtca 1980 ccccgggcgc tctttcggag caccgctggc ctccgctggg ggaggggatc tgtctaatgg 2040 cgttggagtt tgctcacatt tggtgggtgg agactgtagc caggccagcc tggccatgga 2100 agtaattctt ggaatttgcc cattttgagt ttggagcgaa gctgattgac aaagctgctt 2160 agccgttcaa aggtattctt cgaacttttt ttttaaggtg ttgtgaaaac caccagcttc 2220 cttcttcttt ttcctagaag ctcagaataa acgctcaact ttggccgcca cc 2272 <210> 901 <211> 2338 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 901 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaga aacttgatct gtcgccgcaa ttcaagcttc 780 gtgaggctcc ggtgcccgtc agtgacctgc tatagacaag caggggatgg cggggctgac 840 gtcgggaggt ggcctccacg ggaagggaca cccggatctc gacacagcct tggcagtgga 900 gtcaggaagg gtaggacaga ttctggacgc cctcttggcc agtcctcacc gccccacccc 960 cgatggagcc gagagtaatt catacaaaag gagggatcgc cttcgcccct gggaatccca 1020 gggaccgtcg ctaaattctg gccggcctcc cagcccggaa ccgctgtgcc cgcccagcgc 1080 ggcgggagga gcctgcgcct agggcggatc gcgggtcggc gggagagcac aagcccacag 1140 tccccggcgg tgggggaggg gcgcgctgag cgggggcccg ggagccagcg cggggcaaac 1200 tgggaaagtg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg agaacggtat 1260 aaaagtgcgg tagtcgcgtt ggacgttctt tttcgcaacg ggtttgccgt cagaacgcag 1320 gtgagtggcg ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg ggtcggaccg 1380 ccgtgcgggt gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga tggcgggctg 1440 tgcgggaggg cgaggggggg aggcctggcg gcggccccgg agcctcgcct cgtgtcgggc 1500 gtgaggccta gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct ttgctgtctg 1560 cccggctgcc ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg cgtggagctg 1620 gctggtaggg agccccgtag tccgcatgtc gggcagggag agcggcagca gtcggggggg 1680 ggaccgggcc cgcccgtccc gcagcacatg tccgacgccg cctggacggg tagcggcctg 1740 tgtcctgata aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg gccccgggtc 1800 ccggcccggt ctggccagta ccccgtagtg gcttagctcc gaggagggcg agcccgcccg 1860 cccggcacca gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag caaggagctc 1920 aaaatggagg acgcggcagc ccggcggagc ggggcgggtg agtcacccac acaaaggaag 1980 agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc ggccgcactt 2040 cagtcacccc gggcgctctt tcggagcacc gctggcctcc gctgggggag gggatctgtc 2100 taatggcgtt ggagtttgct cacatttggt gggtggagac tgtagccagg ccagcctggc 2160 catggaagta attcttggaa tttgcccatt ttgagtttgg agcgaagctg attgacaaag 2220 ctgcttagcc gttcaaaggt attcttcgaa cttttttttt aaggtgttgt gaaaaccacc 2280 agcttccttc ttctttttcc tagaagctca gaataaacgc tcaactttgg ccgccacc 2338 <210> 902 <211> 1995 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 902 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaga attcgtttat cggccaccga ggccaagatc 780 tggccgccag cacatcgccc acagtccccg agaagttggg aggggtcggc aattgaaccg 840 gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc 900 tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt 960 ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg 1020 gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctccagtacg 1080 tgattcttga tcccgagctg gagccagggg cgggccttgc gctttaggag ccccttcgcc 1140 tcgtgcttga gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca 1200 ccttcgcgcc tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacg 1260 tgctgcgacg ctttttttct ggcaagatag tcttgtaaat gcgggccagg atctgcacac 1320 tggtatttcg gtttttgggc ccgcggccgg cgacggggcc cgtgcgtccc agcgcacatg 1380 ttcggcgagg cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc 1440 tggccggcct gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc 1500 aaggctggcc cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc 1560 tccagggggc tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac 1620 acaaaggaaa agggcctttc cgtcctcagc cgtcgcttca tgtgactcca cggagtaccg 1680 ggcgccgtcc aggcacctcg attagttctg gagcttttgg agtacgtcgt ctttaggttg 1740 gggggagggg ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag 1800 gccagcttgg cacttgatgt aattctcctt ggaatttggc ctttttgagt ttggatcttg 1860 gttcattctc aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg 1920 aacaccatct attgcttagc ttccttcttc tttttcctag aagctcagaa taaacgctca 1980 actttggccg ccacc 1995 <210> 903 <211> 1815 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 903 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacattg attattgact agttattaat 840 agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac 900 ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa 960 tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt 1020 atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc 1080 ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat 1140 gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc 1200 ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc 1260 tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa 1320 aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg 1380 tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagactc catccacgct 1440 gttttgacct ccatagaaga taccgggacc gatccagcct ccgcggccgg gaacggtgca 1500 ttggaacgcg gattccccgt gccaagagtg accctggcag aactcggtaa gtctgttgac 1560 atgtatgtga tgtatactaa cctgcatggg acgtggattt acttgtgtat gtcagataga 1620 gtaaagatta actcttgcat gtgagcgggg catcgagata gcgataaatg agtcaggagg 1680 acggagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc ctgggcaacg 1740 tgctggttat tgtgctgtct catcattttg gcaaagaatt tcaccgtcct tgacacgaag 1800 tttgctgccg ccacc 1815 <210> 904 <211> 1873 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 904 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaattcgt ttatcggcca ccgaggccaa gatctggccg 720 ccaaagtttc cagagctttc gaggaaggtt tcttcaactc aaattcatcc gcctgataat 780 tttcttatat tttcctaaag aaggaagaga agcgcataga ggagaaggga aataattttt 840 taggagcctt tcttacggct atgaggaatt tggggctcag ttgaaaagcc taaactgcct 900 ctcgggaggt tgggcgcggc gaactacttt cagcggcgca cgcagacggc gtctacgtga 960 ggggtgataa gtgacgcaac actcgttgca taaatttgcg ctccgccagc ccggagcatt 1020 taggggcggt tggctttgtt gggtgagctt gtttgtgtcc ctgtgggtgg acgtggttgg 1080 tgattggcag gatcctggta tccgctacag gtactggccc acagccgtaa agagctgcgg 1140 gggcgtgaga ggggggaatg ggtgaggtca agctggaggc ttcttggggt tgggtgggcc 1200 gctgagggga ggggagggcg aggtgacgcg acacccggcc tttctgggag agtgggcctt 1260 gttgacctaa ggggggcgag ggcagttggc acgcgcacgc gccgacagaa actaacagac 1320 attaaccaac agcgattccg tcgcgtttac ttgggaggaa ggcggaaaag aggtagtttg 1380 tgtggcttct ggaaacccta aatttggaat cccagtatga gaatggtgtc ccttcttgtg 1440 tttcaatggg atttttactt cgcgagtctt gtgggtttgg ttttgttttc agtttgccta 1500 acaccgtgct taggtttgag gcagattgga gttcggtcgg gggagtttga atatccggaa 1560 cagttagtgg ggaaagctgt ggacgcttgg taagagagcg ctctggattt tccgctgttg 1620 acgttgaaac cttgaatgac gaatttcgta ttaagtgact tagccttgta aaattgaggg 1680 gaggcttgcg gaatattaac gtatttaagg cattttgaag gaatagttgc taattttgaa 1740 gaatattagg tgtaaaagca agaaatacaa tgatcctgag gtgacacgct tatgttttac 1800 ttttaaacta ggtcaagctt ccttcttctt tttcctagaa gctcagaata aacgctcaac 1860 tttggccgcc acc 1873 <210> 905 <211> 2244 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 905 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaagaaact 660 tgatctgtcg ccgcaattca agcttcgtga ggctccggtg cccgtcagtg acctgctata 720 gacaagcagg ggatggcggg gctgacgtcg ggaggtggcc tccacgggaa gggacacccg 780 gatctcgaca cagccttggc agtggagtca ggaagggtag gacagattct ggacgccctc 840 ttggccagtc ctcaccgccc cacccccgat ggagccgaga gtaattcata caaaaggagg 900 gatcgccttc gcccctggga atcccaggga ccgtcgctaa attctggccg gcctcccagc 960 ccggaaccgc tgtgcccgcc cagcgcggcg ggaggagcct gcgcctaggg cggatcgcgg 1020 gtcggcggga gagcacaagc ccacagtccc cggcggtggg ggaggggcgc gctgagcggg 1080 ggcccgggag ccagcgcggg gcaaactggg aaagtggtgt cgtgtgctgg ctccgccctc 1140 ttcccgaggg tgggggagaa cggtataaaa gtgcggtagt cgcgttggac gttctttttc 1200 gcaacgggtt tgccgtcaga acgcaggtga gtggcgggtg tggcctccgc gggcccgggc 1260 tccctccttt gagcggggtc ggaccgccgt gcgggtgtcg tcggccgggc ttctctgcga 1320 gcgttcccgc cctggatggc gggctgtgcg ggagggcgag ggggggaggc ctggcggcgg 1380 ccccggagcc tcgcctcgtg tcgggcgtga ggcctagcgt ggcttccgcc ccgccgcgtg 1440 ccaccgcggc cgcgctttgc tgtctgcccg gctgccctcg attgcctgcc cgcggcccgg 1500 gccaacaaag ggagggcgtg gagctggctg gtagggagcc ccgtagtccg catgtcgggc 1560 agggagagcg gcagcagtcg ggggggggac cgggcccgcc cgtcccgcag cacatgtccg 1620 acgccgcctg gacgggtagc ggcctgtgtc ctgataaggc ggccgggcgg tgggttttag 1680 atgccgggtt caggtggccc cgggtcccgg cccggtctgg ccagtacccc gtagtggctt 1740 agctccgagg agggcgagcc cgcccgcccg gcaccagttg cgtgcgcgga aagatggccg 1800 ctcccgggcc ctgtagcaag gagctcaaaa tggaggacgc ggcagcccgg cggagcgggg 1860 cgggtgagtc acccacacaa aggaagaggg ccttgcccct cgccggccgc tgcttcctgt 1920 gaccccgtgg tgtaccggcc gcacttcagt caccccgggc gctctttcgg agcaccgctg 1980 gcctccgctg ggggagggga tctgtctaat ggcgttggag tttgctcaca tttggtgggt 2040 ggagactgta gccaggccag cctggccatg gaagtaattc ttggaatttg cccattttga 2100 gtttggagcg aagctgattg acaaagctgc ttagccgttc aaaggtattc ttcgaacttt 2160 ttttttaagg tgttgtgaaa accaccagct tccttcttct ttttcctaga agctcagaat 2220 aaacgctcaa ctttggccgc cacc 2244 <210> 906 <211> 2049 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 906 ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac 60 tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca 120 ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aatacaatag 180 caggcatgct ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg 240 ttcctcctgg gatattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 300 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 360 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 420 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 480 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 540 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaaag cggggctgac 600 gtcgggaggt ggcctccgtg ggaagggaca cccggatctt gacacagcct tggcagcgga 660 gtaaggaaga gtagggatag attctggccg ccctcttggc cagcttctcg ccgccccacc 720 ctccgctagg gccaagagta attcatacaa aaggagggat cgccttcgca aggggagagc 780 ccagggaccg tccctaaatt ctcacagacc caaatccctg tagccgcccc acgacagcgc 840 gaggagcatg cgctcagggc tgagcgcggg gagagcagag cacacaagct catagaccct 900 ggtcgtgggg gggaggaccg gggagctggc gcggggcaaa ctgggaaagc ggtgtcgtgt 960 gctggctccg ccctcttccc gagggtgggg gagaacggta tataagtgcg gcagtcgcct 1020 tggacgttct ttttcgcaac gggtttgccg tcagaacgca ggtgaggggc gggtgtggct 1080 tccgcgggcc gccgagctgg aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc 1140 ggggattagc tgcgagcatt cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga 1200 ggcctagcgg caaccccgta gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc 1260 gcgccgccgc cgcgtgctac tccggccgca ctctggtctt tttttttttg ttgttgttgc 1320 cctgctgcct tcgattgccg ttcagcaata ggggctaaca aagggagggt gcggggcttg 1380 ctcgcccgga gcccggagag gtcatggttg gggaggaatg gagggacagg agtggcggct 1440 ggggcccgcc cgccttcgga gcacatgtcc gacgccacct ggatggggcg aggcctgggg 1500 tttttcccga agcaaccagg ctggggttag cgtgccgagg ccatgtggcc ccagcacccg 1560 gcacgatctg gcttggcggc gccgcgttgc cctgcctccc taactagggt gaggccatcc 1620 cgtccggcac cagttgcgtg cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc 1680 tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa 1740 gagggcctgg tccctcaccg gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa 1800 tagtcacctc gggcttttga gcacggctag tcgcggcggg gggaggggat gtaatggcgt 1860 tggagtttgt tcacatttgg tgggtggaga ctagtcaggc cagcctggcg ctggaagtca 1920 tttttggaat ttgtcccctt gagttttgag cggagctaat tctcgggctt cttagcggtt 1980 caaaggtatc ttttaaaccc ttttttaggt gttgtgaaaa ccaccgctaa ttcaaagcaa 2040 gccgccacc 2049 <210> 907 <211> 1215 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 907 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaacg gtccgaattt caaagtcttt ttcctattga 780 cctacaaggt tttcaagaat catgttgtaa gcaactgtgt tctgaggaat ctatgtttaa 840 aaacccatcc gtggatcttg gcccagggtc cagagactga gctagccacg ccccggccgc 900 gccgcagcca ctcccacggc agttcaagtg ttaagtccca aagaccgcgc tctgtgcatg 960 cgcagacccg tccacagctg gctcctagcc aacccggccg gacgagcacc cggcgccgtc 1020 acgtgacgca cccaaccggc gtcgacctat aaaaggccgg gcgttgacgt cagcgttctc 1080 ttccgccgca gccgccgcca tcgtcggcgc gcttccctgt tcacctctga ctctgagaat 1140 ccgtcgccat ccgccagagc ttccttcttc tttttcctag aagctcagaa taaacgctca 1200 actttggccg ccacc 1215 <210> 908 <211> 1155 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 908 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaggatccaa cttctaagtc cgttttttat tgatctaaaa 720 ggccttttgc gaatcatctt gaaggcaatc gcgttctgag ccacctcagc tttggcacac 780 agcgcgggga ctgtcgcgag gggtttaggg cccaagcagg acacaccccg aaatctccgc 840 agccaccccc accccacgcc cccggctctt gagggttaaa tcgcaggcgc tggttctcgc 900 acgcgcacat catcccgcag gcgagcccca gcacccagcc cagggtgcgc gcgcgccgtc 960 acgtgacacg cccaaccggc gtcgccgtat aaaagcgcgg gcgttgacgt cagcgttctc 1020 ttccgccgca gccgccgcca tcgtcggcgc ccctcgcact tctcctgtgc ccgtgagaat 1080 ccgtcgccat ccgccagagc ttccttcttc tttttcctag aagctcagaa taaacgctca 1140 actttggccg ccacc 1155 <210> 909 <211> 2707 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 909 aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct 60 ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt 120 atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg 180 tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact 240 ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct 300 attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg 360 ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc 420 gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc 480 aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcctctt 540 cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcg ggggaggcta 600 actgaaacac ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga 660 cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa cgcggggttc ggtcccaggg 720 ctggcactct gtcgataccc caccgagtcc ccattggggc caatacgccc gcgtttcttc 780 cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag ccaacgtcgg 840 ggcggcaggc cctgccatag aaatcgataa tatatggtag ggttcatagc cagagtaacc 900 ttttttttta atttttattt tattttattt ttgagtcggg cgcgccaaaa tgaagtgaag 960 ttcctatact ttctagagcg agctcacggg gacagccccc ccccaaagcc cccagggatg 1020 taattacgtc cctcccccgc tagggggcag cagcgagccg cccggggctc cgctccggtc 1080 cggcgctccc cccgcatccc cgagccggca gcgtgcgggg acagcccggg cacggggaag 1140 gtggcacggg atcgctttcc tctgaacgct tctcgctgct ctttgagcct gcagacacct 1200 ggggggatac ggggaaaaag ctttaggctg aaagagagat ttagaatgac agagcggggc 1260 tgacgtcggg aggtggcctc cgtgggaagg gacacccgga tcttgacaca gccttggcag 1320 cggagtaagg aagagtaggg atagattctg gccgccctct tggccagctt ctcgccgccc 1380 caccctccgc tagggccaag agtaattcat acaaaaggag ggatcgcctt cgcaagggga 1440 gagcccaggg accgtcccta aattctcaca gacccaaatc cctgtagccg ccccacgaca 1500 gcgcgaggag catgcgctca gggctgagcg cggggagagc agagcacaca agctcataga 1560 ccctggtcgt gggggggagg accggggagc tggcgcgggg caaactggga aagcggtgtc 1620 gtgtgctggc tccgccctct tcccgagggt gggggagaac ggtatataag tgcggcagtc 1680 gccttggacg ttctttttcg caacgggttt gccgtcagaa cgcaggtgag gggcgggtgt 1740 ggcttccgcg ggccgccgag ctggaggtcc tgctccgagc gggccgggcc ccgctgtcgt 1800 cggcggggat tagctgcgag cattcccgct tcgagttgcg ggcggcgcgg gaggcagagt 1860 gcgaggccta gcggcaaccc cgtagcctcg cctcgtgtcc ggcttgaggc ctagcgtggt 1920 gtccgcgccg ccgccgcgtg ctactccggc cgcactctgg tctttttttt ttttgttgtt 1980 gttgccctgc tgccttcgat tgccgttcag caataggggc taacaaaggg agggtgcggg 2040 gcttgctcgc ccggagcccg gagaggtcat ggttggggag gaatggaggg acaggagtgg 2100 cggctggggc ccgcccgcct tcggagcaca tgtccgacgc cacctggatg gggcgaggcc 2160 tggggttttt cccgaagcaa ccaggctggg gttagcgtgc cgaggccatg tggccccagc 2220 acccggcacg atctggcttg gcggcgccgc gttgccctgc ctccctaact agggtgaggc 2280 catcccgtcc ggcaccagtt gcgtgcgtgg aaagatggcc gctcccgggc cctgttgcaa 2340 ggagctcaaa atggaggacg cggcagcccg gtggagcggg cgggtgagtc acccacacaa 2400 aggaagaggg cctggtccct caccggctgc tgcttcctgt gaccccgtgg tcctatcggc 2460 cgcaatagtc acctcgggct tttgagcacg gctagtcgcg gcggggggag gggatgtaat 2520 ggcgttggag tttgttcaca tttggtgggt ggagactagt caggccagcc tggcgctgga 2580 agtcattttt ggaatttgtc cccttgagtt ttgagcggag ctaattctcg ggcttcttag 2640 cggttcaaag gtatctttta aacccttttt taggtgttgt gaaaaccacc gctaattcaa 2700 agcaacc 2707 <210> 910 <211> 1290 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 910 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaatgacgtc gaggagaagt tccccaactt tcccgcctct 720 cagcctttga aagaaagaaa ggggaggggg caggccgcgt gcagccgcga gcggtgctgg 780 gctccggctc caattcccca tctcagtcgt tcccaaagtc ctcctgtttc atccaagcgt 840 gtaagggtcc ccgtccttga ctccctagtg tcctgctgcc cacagtccag tcctgggaac 900 cagcaccgat cacctcccat cgggccaatc tcagtccctt cccccctacg tcggggccca 960 cacgctcggt gcgtgcccag ttgaaccagg cggctgcgga aaaaaaaaag cggggagaaa 1020 gtagggcccg gctactagcg gttttacggg cgcacgtagc tcaggcctca agaccttggg 1080 ctgggactgg ctgagcctgg cgggaggcgg ggtccgagtc accgcctgcc gccgcgcccc 1140 cggtttctat aaattgagcc cgcagcctcc cgcttcgctc tctgctcctc ctgttcgaca 1200 gtcagccgca tcttcttttg cgtcgccagg gggagcttgc ttgttctttt tgcagaagct 1260 cagaataaac gctcaacttt ggccgccacc 1290 <210> 911 <211> 1382 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 911 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aacgaagaac aacgagaaga tcctcaactt ctcctaagcc 720 ttttcactaa tagggagaag ttcgatgggg cagccttggg cagacccaca cttctgctcc 780 atttccctgg ttcctgcagc tctcagattc tcccatttta ttcgggaagc agctttctgg 840 tttctgggtc ctggatgtcc ttggtgcaca ctccaaggac tcctcgtcct taatccatag 900 tctgtattcc ctgagtccta tcctgggaac cctcatccgg tcacttcctc ggcgggacaa 960 tctcagctcc cctccccctc tcaggtcgga gcccacacgc ttggtgcgtg cacatttcaa 1020 aaacgaggcg ggtccaaaaa gagggagggg gggaatgaga gaggcccagc tactcgcggc 1080 tttacgggtg cacgtagctc aggcctctgc gcccttgagc tgggactgga tgagccgagc 1140 gggaggcggg gcgcgcgtca tcagctcccc ccaccatcca gttcctataa atacggactg 1200 cagccctccc tggtgctctc tgctcctccc tgttctagag acagccgcat cttcttgtgc 1260 agtgccaggc tctctgctcc tcctgttcga cagtcagccg catcttcttt tgcgtcgcca 1320 gggggagctt gcttgttctt tttgcagaag ctcagaataa acgctcaact ttggccgcca 1380 cc 1382 <210> 912 <211> 1151 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 912 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagggtccga atttcaaagt cctttttatt gacttacaag 720 gttttcaagg aaaatcttgg aagtaactgt gttccgaaga atctacgttt aaaaaccgac 780 ccctggatct ttgccttggg tccaaggacc gagctggcca cgccccagcc gcgccgcagc 840 cactcccaag gcagttcaag tgttaagccc gaaaggtaga gctctgcgca tgtgcacacc 900 cgtccatagc tgggtcccag ccaaccaggc cggaggagca cccgcgccgt cacgtgacgt 960 gcccaaccgg cgtcgaccta taaaaggccg ggcgttgacg tcagcggact cttccgccgc 1020 agccgccgcc atcgtcggcg cgcttccctg ttcacctctg tatttgagaa tccgacgcca 1080 tctgccacca ggggagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt 1140 tggccgccac c 1151 <210> 913 <211> 1151 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 913 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aacggtccga atttcaaagt ctttttccta ttgacctaca 720 aggttttcaa gaatcatgtt gtaagcaact gtgttctgag gaatctatgt ttaaaaaccc 780 atccgtggat cttggcccag ggtccagaga ctgagctagc cacgccccgg ccgcgccgca 840 gccactccca cggcagttca agtgttaagt cccaaagacc gcgctctgtg catgcgcaga 900 cccgtccaca gctggctcct agccaacccg gccggacgag cacccggcgc cgtcacgtga 960 cgcacccaac cggcgtcgac ctataaaagg ccgggcgttg acgtcagcgt tctcttccgc 1020 cgcagccgcc gccatcgtcg gcgcgcttcc ctgttcacct ctgactctga gaatccgtcg 1080 ccatccgcca ggggagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt 1140 tggccgccac c 1151 <210> 914 <211> 1991 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 914 gatccttttc cctctgacca gaattatggg aacatcatga agccccttga gcatctagct 60 tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 120 tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt 180 tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga 240 ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg 300 acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta 360 aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc 420 atagctgtcc ctcttctctt atggagatcc ctctcccggc cagaggagca aggtatgcgg 480 gaggcgacca ggaggatagc ggggctgacg tcgggaggtg gcctccgtgg gaaggacacc 540 cggatcttga cacagccttg gcagcggagt caggaagagt aggggtaggt tctggacgcc 600 ctcttggcca gctcatcgcc gccccaccct ctgctggagc acagagtaat tcatacaaaa 660 ggagggatcg ccttcgcaag gggagagccc agggaccgtc cctaaattct cacagaccca 720 aatccctgta gccgccccac gacagcgcga ggagcatgcg cccagggctg agcgcgggta 780 gatcagagca cacaagctca cagtccccgg cggtgggggg aggggcgcgc tgagcggggg 840 ccagggagct ggcgcggggc aaactgggaa agtggtgtcg tgtgctggct ccgccctctt 900 cccgagggtg ggggagaacg gtatataagt gcggtagtcg ccttggacgt tctttttcgc 960 aacgggtttg ccgtcagaac gcaggtgagt ggcgggtgtg gcttccgcgg gccccggagc 1020 tggagccctg ctctgagcgg gccgggctga tatgcgagtg tcgtccgcag ggtttagctg 1080 tgagcattcc cacttcgagt ggcgggcggt gcgggggtga gagtgcgagg cctagcggca 1140 accccgtagc ctcgcctcgt gtccggcttg aggcctagcg tggtgtccgc cgccgcgtgc 1200 cactccggcc gcactatgcg ttttttgtcc ttgctgccct cgattgcctt ccagcagcat 1260 gggctaacaa agggagggtg tggggctcac tcttaaggag cccatgaagc ttacgttgga 1320 taggaatgga agggcaggag gggcgactgg ggcccgcccg ccttcggagc acatgtccga 1380 cgccacctgg atggggcgag gcctgtggct ttccgaagca atcgggcgtg agtttagcct 1440 acctgggcca tgtggcccta gcactgggca cggtctggcc tggcggtgcc gcgttccctt 1500 gcctcccaac aagggtgagg ccgtcccgcc cggcaccagt tgcttgcgcg gaaagatggc 1560 cgctcccggg gccctgttgc aaggagctca aaatggagga cgcggcagcc cggtggagcg 1620 ggcgggtgag tcacccacac aaaggaagag ggccttgccc ctcgccggcc gctgcttcct 1680 gtgaccccgt ggtctatcgg ccgcatagtc acctcgggct tctcttgagc accgctcgtc 1740 gcggcggggg gaggggatct aatggcgttg gagtttgttc acatttggtg ggtggagact 1800 agtcaggcca gcctggcgct ggaagtcatt cttggaattt gcccctttga gtttggagcg 1860 aggctaattc tcaagcctct tagcggttca aaggtatttt ctaaacccgt ttccaggtgt 1920 tgtgaaaacc accagcttcc ttcttctttt tcctagaagc tcagaataaa cgctcaactt 1980 tggccgccac c 1991 <210> 915 <211> 2005 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 915 gatccttttc cctctgacca gaattatggg aacatcatga agccccttga gcatctagct 60 tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 120 tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt 180 tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga 240 ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg 300 acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta 360 aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc 420 atagctgtcc ctcttctctt atggagatcg ttaaatgaga aacctgtgtg ttcctttggg 480 gcggggctga cgtcgggagg tggcctccac gggaagggac acccggatct cgacacagcc 540 ttggcagtgg agtcaggaag ggtaggacag attctggacg ccctcttggc cagtcctcac 600 cgccccaccc ccgatggagc cgagagtaat tcatacaaaa ggagggatcg ccttcgcccc 660 tgggaatccc agggaccgtc gctaaattct ggccggcctc ccagcccgga accgctgtgc 720 ccgcccagcg cggcgggagg agcctgcgcc tagggcggat cgcgggtcgg cgggagagca 780 caagcccaca gtccccggcg gtgggggagg ggcgcgctga gcgggggccc gggagccagc 840 gcggggcaaa ctgggaaagt ggtgtcgtgt gctggctccg ccctcttccc gagggtgggg 900 gagaacggta taaaagtgcg gtagtcgcgt tggacgttct ttttcgcaac gggtttgccg 960 tcagaacgca ggtgagtggc gggtgtggcc tccgcgggcc cgggctccct cctttgagcg 1020 gggtcggacc gccgtgcggg tgtcgtcggc cgggcttctc tgcgagcgtt cccgccctgg 1080 atggcgggct gtgcgggagg gcgagggggg gaggcctggc ggcggccccg gagcctcgcc 1140 tcgtgtcggg cgtgaggcct agcgtggctt ccgccccgcc gcgtgccacc gcggccgcgc 1200 tttgctgtct gcccggctgc cctcgattgc ctgcccgcgg cccgggccaa caaagggagg 1260 gcgtggagct ggctggtagg gagccccgta gtccgcatgt cgggcaggga gagcggcagc 1320 agtcgggggg gggaccgggc ccgcccgtcc cgcagcacat gtccgacgcc gcctggacgg 1380 gtagcggcct gtgtcctgat aaggcggccg ggcggtgggt tttagatgcc gggttcaggt 1440 ggccccgggt cccggcccgg tctggccagt accccgtagt ggcttagctc cgaggagggc 1500 gagcccgccc gcccggcacc agttgcgtgc gcggaaagat ggccgctccc gggccctgta 1560 gcaaggagct caaaatggag gacgcggcag cccggcggag cggggcgggt gagtcaccca 1620 cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc cgtggtgtac 1680 cggccgcact tcagtcaccc cgggcgctct ttcggagcac cgctggcctc cgctggggga 1740 ggggatctgt ctaatggcgt tggagtttgc tcacatttgg tgggtggaga ctgtagccag 1800 gccagcctgg ccatggaagt aattcttgga atttgcccat tttgagtttg gagcgaagct 1860 gattgacaaa gctgcttagc cgttcaaagg tattcttcga actttttttt taaggtgttg 1920 tgaaaaccac cgctaattca aatccaacag cttgcttgtt ctttttgcag aagctcagaa 1980 taaacgctca actttggccg ccacc 2005 <210> 916 <211> 2186 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 916 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aacctctccc ggccagagga gcaaggtatg cgggaggcga 720 ccaggaggat agcggggctg acgtcgggag gtggcctccg tgggaaggac acccggatct 780 tgacacagcc ttggcagcgg agtcaggaag agtaggggta ggttctggac gccctcttgg 840 ccagctcatc gccgccccac cctctgctgg agcacagagt aattcataca aaaggaggga 900 tcgccttcgc aaggggagag cccagggacc gtccctaaat tctcacagac ccaaatccct 960 gtagccgccc cacgacagcg cgaggagcat gcgcccaggg ctgagcgcgg gtagatcaga 1020 gcacacaagc tcacagtccc cggcggtggg gggaggggcg cgctgagcgg gggccaggga 1080 gctggcgcgg ggcaaactgg gaaagtggtg tcgtgtgctg gctccgccct cttcccgagg 1140 gtgggggaga acggtatata agtgcggtag tcgccttgga cgttcttttt cgcaacgggt 1200 ttgccgtcag aacgcaggtg agtggcgggt gtggcttccg cgggccccgg agctggagcc 1260 ctgctctgag cgggccgggc tgatatgcga gtgtcgtccg cagggtttag ctgtgagcat 1320 tcccacttcg agtggcgggc ggtgcggggg tgagagtgcg aggcctagcg gcaaccccgt 1380 agcctcgcct cgtgtccggc ttgaggccta gcgtggtgtc cgccgccgcg tgccactccg 1440 gccgcactat gcgttttttg tccttgctgc cctcgattgc cttccagcag catgggctaa 1500 caaagggagg gtgtggggct cactcttaag gagcccatga agcttacgtt ggataggaat 1560 ggaagggcag gaggggcgac tggggcccgc ccgccttcgg agcacatgtc cgacgccacc 1620 tggatggggc gaggcctgtg gctttccgaa gcaatcgggc gtgagtttag cctacctggg 1680 ccatgtggcc ctagcactgg gcacggtctg gcctggcggt gccgcgttcc cttgcctccc 1740 aacaagggtg aggccgtccc gcccggcacc agttgcttgc gcggaaagat ggccgctccc 1800 ggggccctgt tgcaaggagc tcaaaatgga ggacgcggca gcccggtgga gcgggcgggt 1860 gagtcaccca cacaaaggaa gagggccttg cccctcgccg gccgctgctt cctgtgaccc 1920 cgtggtctat cggccgcata gtcacctcgg gcttctcttg agcaccgctc gtcgcggcgg 1980 ggggagggga tctaatggcg ttggagtttg ttcacatttg gtgggtggag actagtcagg 2040 ccagcctggc gctggaagtc attcttggaa tttgcccctt tgagtttgga gcgaggctaa 2100 ttctcaagcc tcttagcggt tcaaagtttt tttcttccat ttcaggtgtt gtgaaagcca 2160 ccgctaattc aaagcaagcc gccacc 2186 <210> 917 <211> 2139 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 917 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aaagcggggc tgacgtcggg aggtggcctc cgtgggaagg 720 gacacccgga tcttgacaca gccttggcag cggagtaagg aagagtaggg atagattctg 780 gccgccctct tggccagctt ctcgccgccc caccctccgc tagggccaag agtaattcat 840 acaaaaggag ggatcgcctt cgcaagggga gagcccaggg accgtcccta aattctcaca 900 gacccaaatc cctgtagccg ccccacgaca gcgcgaggag catgcgctca gggctgagcg 960 cggggagagc agagcacaca agctcataga ccctggtcgt gggggggagg accggggagc 1020 tggcgcgggg caaactggga aagcggtgtc gtgtgctggc tccgccctct tcccgagggt 1080 gggggagaac ggtatataag tgcggcagtc gccttggacg ttctttttcg caacgggttt 1140 gccgtcagaa cgcaggtgag gggcgggtgt ggcttccgcg ggccgccgag ctggaggtcc 1200 tgctccgagc gggccgggcc ccgctgtcgt cggcggggat tagctgcgag cattcccgct 1260 tcgagttgcg ggcggcgcgg gaggcagagt gcgaggccta gcggcaaccc cgtagcctcg 1320 cctcgtgtcc ggcttgaggc ctagcgtggt gtccgcgccg ccgccgcgtg ctactccggc 1380 cgcactctgg tctttttttt tttgttgttg ttgccctgct gccttcgatt gccgttcagc 1440 aataggggct aacaaaggga gggtgcgggg cttgctcgcc cggagcccgg agaggtcatg 1500 gttggggagg aatggaggga caggagtggc ggctggggcc cgcccgcctt cggagcacat 1560 gtccgacgcc acctggatgg ggcgaggcct ggggtttttc ccgaagcaac caggctgggg 1620 ttagcgtgcc gaggccatgt ggccccagca cccggcacga tctggcttgg cggcgccgcg 1680 ttgccctgcc tccctaacta gggtgaggcc atcccgtccg gcaccagttg cgtgcgtgga 1740 aagatggccg ctcccgggcc ctgttgcaag gagctcaaaa tggaggacgc ggcagcccgg 1800 tggagcgggc gggtgagtca cccacacaaa ggaagagggc ctggtccctc accggctgct 1860 gcttcctgtg accccgtggt cctatcggcc gcaatagtca cctcgggctt ttgagcacgg 1920 ctagtcgcgg cggggggagg ggatgtaatg gcgttggagt ttgttcacat ttggtgggtg 1980 gagactagtc aggccagcct ggcgctggaa gtcatttttg gaatttgtcc ccttgagttt 2040 tgagcggagc taattctcgg gcttcttagc ggttcaaagt ttttttcttc catttcaggt 2100 gttgtgaaaa ccaccgctaa ttcaaagcaa gccgccacc 2139 <210> 918 <211> 2232 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 918 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaattgcca gccatctgtt gtttgcccct 120 cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg 180 aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc 240 aggacagcaa gggggaggat tgggaataca atagcaggca tgctggggat gcggtgggct 300 ctatgggtac ccaggtgctg aagaattgac ccggttcctc ctgggatatt atccctaata 360 cttgccaccc cactcttaat cagtggtgga agaacggtgt cagaactgtt tgtttcaatt 420 ggccatttaa gtttagtagt aaaagactgg ttaatgataa caatgcatcg taaaaccttc 480 agaaggaaag gagaatgttt tgtggaccac tttggttttc ttttttgcgt gtggcagttt 540 taagttatta gtttttaaaa tcagtacttt ttaatggaaa caacttgacc aaaaatttgt 600 cacagaattt tgagatccat taaaaaagtt aaatgagaaa cctgtgtgtt cctttggtca 660 acaccgagac atttaggtga aagaaacttg atctgtcgcc gcaattcaag cttcgtgagg 720 ctccggtgcc cgtcagtgac ctgctataga caagcagggg atggcggggc tgacgtcggg 780 aggtggcctc cacgggaagg gacacccgga tctcgacaca gccttggcag tggagtcagg 840 aagggtagga cagattctgg acgccctctt ggccagtcct caccgcccca cccccgatgg 900 agccgagagt aattcataca aaaggaggga tcgccttcgc ccctgggaat cccagggacc 960 gtcgctaaat tctggccggc ctcccagccc ggaaccgctg tgcccgccca gcgcggcggg 1020 aggagcctgc gcctagggcg gatcgcgggt cggcgggaga gcacaagccc acagtccccg 1080 gcggtggggg aggggcgcgc tgagcggggg cccgggagcc agcgcggggc aaactgggaa 1140 agtggtgtcg tgtgctggct ccgccctctt cccgagggtg ggggagaacg gtataaaagt 1200 gcggtagtcg cgttggacgt tctttttcgc aacgggtttg ccgtcagaac gcaggtgagt 1260 ggcgggtgtg gcctccgcgg gcccgggctc cctcctttga gcggggtcgg accgccgtgc 1320 gggtgtcgtc ggccgggctt ctctgcgagc gttcccgccc tggatggcgg gctgtgcggg 1380 agggcgaggg ggggaggcct ggcggcggcc ccggagcctc gcctcgtgtc gggcgtgagg 1440 cctagcgtgg cttccgcccc gccgcgtgcc accgcggccg cgctttgctg tctgcccggc 1500 tgccctcgat tgcctgcccg cggcccgggc caacaaaggg agggcgtgga gctggctggt 1560 agggagcccc gtagtccgca tgtcgggcag ggagagcggc agcagtcggg ggggggaccg 1620 ggcccgcccg tcccgcagca catgtccgac gccgcctgga cgggtagcgg cctgtgtcct 1680 gataaggcgg ccgggcggtg ggttttagat gccgggttca ggtggccccg ggtcccggcc 1740 cggtctggcc agtaccccgt agtggcttag ctccgaggag ggcgagcccg cccgcccggc 1800 accagttgcg tgcgcggaaa gatggccgct cccgggccct gtagcaagga gctcaaaatg 1860 gaggacgcgg cagcccggcg gagcggggcg ggtgagtcac ccacacaaag gaagagggcc 1920 ttgcccctcg ccggccgctg cttcctgtga ccccgtggtg taccggccgc acttcagtca 1980 ccccgggcgc tctttcggag caccgctggc ctccgctggg ggaggggatc tgtctaatgg 2040 cgttggagtt tgctcacatt tggtgggtgg agactgtagc caggccagcc tggccatgga 2100 agtaattctt ggaatttgcc cattttgagt ttggagcgaa gctgattgac aaagctgctt 2160 agccgttcaa agtttttttc ttccatttca ggtgttgtga aaaccaccgc taattcaaag 2220 caagccgcca cc 2232 <210> 919 <211> 2252 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 919 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaacc tctcccggcc agaggagcaa ggtatgcggg 780 aggcgaccag gaggatagcg gggctgacgt cgggaggtgg cctccgtggg aaggacaccc 840 ggatcttgac acagccttgg cagcggagtc aggaagagta ggggtaggtt ctggacgccc 900 tcttggccag ctcatcgccg ccccaccctc tgctggagca cagagtaatt catacaaaag 960 gagggatcgc cttcgcaagg ggagagccca gggaccgtcc ctaaattctc acagacccaa 1020 atccctgtag ccgccccacg acagcgcgag gagcatgcgc ccagggctga gcgcgggtag 1080 atcagagcac acaagctcac agtccccggc ggtgggggga ggggcgcgct gagcgggggc 1140 cagggagctg gcgcggggca aactgggaaa gtggtgtcgt gtgctggctc cgccctcttc 1200 ccgagggtgg gggagaacgg tatataagtg cggtagtcgc cttggacgtt ctttttcgca 1260 acgggtttgc cgtcagaacg caggtgagtg gcgggtgtgg cttccgcggg ccccggagct 1320 ggagccctgc tctgagcggg ccgggctgat atgcgagtgt cgtccgcagg gtttagctgt 1380 gagcattccc acttcgagtg gcgggcggtg cgggggtgag agtgcgaggc ctagcggcaa 1440 ccccgtagcc tcgcctcgtg tccggcttga ggcctagcgt ggtgtccgcc gccgcgtgcc 1500 actccggccg cactatgcgt tttttgtcct tgctgccctc gattgccttc cagcagcatg 1560 ggctaacaaa gggagggtgt ggggctcact cttaaggagc ccatgaagct tacgttggat 1620 aggaatggaa gggcaggagg ggcgactggg gcccgcccgc cttcggagca catgtccgac 1680 gccacctgga tggggcgagg cctgtggctt tccgaagcaa tcgggcgtga gtttagccta 1740 cctgggccat gtggccctag cactgggcac ggtctggcct ggcggtgccg cgttcccttg 1800 cctcccaaca agggtgaggc cgtcccgccc ggcaccagtt gcttgcgcgg aaagatggcc 1860 gctcccgggg ccctgttgca aggagctcaa aatggaggac gcggcagccc ggtggagcgg 1920 gcgggtgagt cacccacaca aaggaagagg gccttgcccc tcgccggccg ctgcttcctg 1980 tgaccccgtg gtctatcggc cgcatagtca cctcgggctt ctcttgagca ccgctcgtcg 2040 cggcgggggg aggggatcta atggcgttgg agtttgttca catttggtgg gtggagacta 2100 gtcaggccag cctggcgctg gaagtcattc ttggaatttg cccctttgag tttggagcga 2160 ggctaattct caagcctctt agcggttcaa agtttttttc ttccatttca ggtgttgtga 2220 aagccaccgc taattcaaag caagccgcca cc 2252 <210> 920 <211> 2205 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 920 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaag cggggctgac gtcgggaggt ggcctccgtg 780 ggaagggaca cccggatctt gacacagcct tggcagcgga gtaaggaaga gtagggatag 840 attctggccg ccctcttggc cagcttctcg ccgccccacc ctccgctagg gccaagagta 900 attcatacaa aaggagggat cgccttcgca aggggagagc ccagggaccg tccctaaatt 960 ctcacagacc caaatccctg tagccgcccc acgacagcgc gaggagcatg cgctcagggc 1020 tgagcgcggg gagagcagag cacacaagct catagaccct ggtcgtgggg gggaggaccg 1080 gggagctggc gcggggcaaa ctgggaaagc ggtgtcgtgt gctggctccg ccctcttccc 1140 gagggtgggg gagaacggta tataagtgcg gcagtcgcct tggacgttct ttttcgcaac 1200 gggtttgccg tcagaacgca ggtgaggggc gggtgtggct tccgcgggcc gccgagctgg 1260 aggtcctgct ccgagcgggc cgggccccgc tgtcgtcggc ggggattagc tgcgagcatt 1320 cccgcttcga gttgcgggcg gcgcgggagg cagagtgcga ggcctagcgg caaccccgta 1380 gcctcgcctc gtgtccggct tgaggcctag cgtggtgtcc gcgccgccgc cgcgtgctac 1440 tccggccgca ctctggtctt tttttttttg ttgttgttgc cctgctgcct tcgattgccg 1500 ttcagcaata ggggctaaca aagggagggt gcggggcttg ctcgcccgga gcccggagag 1560 gtcatggttg gggaggaatg gagggacagg agtggcggct ggggcccgcc cgccttcgga 1620 gcacatgtcc gacgccacct ggatggggcg aggcctgggg tttttcccga agcaaccagg 1680 ctggggttag cgtgccgagg ccatgtggcc ccagcacccg gcacgatctg gcttggcggc 1740 gccgcgttgc cctgcctccc taactagggt gaggccatcc cgtccggcac cagttgcgtg 1800 cgtggaaaga tggccgctcc cgggccctgt tgcaaggagc tcaaaatgga ggacgcggca 1860 gcccggtgga gcgggcgggt gagtcaccca cacaaaggaa gagggcctgg tccctcaccg 1920 gctgctgctt cctgtgaccc cgtggtccta tcggccgcaa tagtcacctc gggcttttga 1980 gcacggctag tcgcggcggg gggaggggat gtaatggcgt tggagtttgt tcacatttgg 2040 tgggtggaga ctagtcaggc cagcctggcg ctggaagtca tttttggaat ttgtcccctt 2100 gagttttgag cggagctaat tctcgggctt cttagcggtt caaagttttt ttcttccatt 2160 tcaggtgttg tgaaaaccac cgctaattca aagcaagccg ccacc 2205 <210> 921 <211> 2298 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 921 gctggagcct cggtagccgt tcctcctgcc cgctgggcct cccaacgggc cctcctcccc 60 tccttgcacc ggcccttcct ggtctttgaa taaatggcta ataaaggaaa tttattttca 120 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aagaacatat gggagggcaa 180 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 240 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 300 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 360 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 420 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 480 catattaccc ctaacacctg ccaccccagt cttaatcagt ggtggaagaa ctctcagaac 540 tgtttgtctc aattggccat ttaagtttaa tagtgaaaga ctggttaatg ataacaatgc 600 atcggaaaac cttcaggagg aaaggagaat gttttgtgga acatttttgt gtgtgtggca 660 gttttaagtt attagttttc aaaatcagta ctttttaatg gaaacaactt gaccaaaaat 720 ctgtcacaga attttgaacc cattaaaaga aacttgatct gtcgccgcaa ttcaagcttc 780 gtgaggctcc ggtgcccgtc agtgacctgc tatagacaag caggggatgg cggggctgac 840 gtcgggaggt ggcctccacg ggaagggaca cccggatctc gacacagcct tggcagtgga 900 gtcaggaagg gtaggacaga ttctggacgc cctcttggcc agtcctcacc gccccacccc 960 cgatggagcc gagagtaatt catacaaaag gagggatcgc cttcgcccct gggaatccca 1020 gggaccgtcg ctaaattctg gccggcctcc cagcccggaa ccgctgtgcc cgcccagcgc 1080 ggcgggagga gcctgcgcct agggcggatc gcgggtcggc gggagagcac aagcccacag 1140 tccccggcgg tgggggaggg gcgcgctgag cgggggcccg ggagccagcg cggggcaaac 1200 tgggaaagtg gtgtcgtgtg ctggctccgc cctcttcccg agggtggggg agaacggtat 1260 aaaagtgcgg tagtcgcgtt ggacgttctt tttcgcaacg ggtttgccgt cagaacgcag 1320 gtgagtggcg ggtgtggcct ccgcgggccc gggctccctc ctttgagcgg ggtcggaccg 1380 ccgtgcgggt gtcgtcggcc gggcttctct gcgagcgttc ccgccctgga tggcgggctg 1440 tgcgggaggg cgaggggggg aggcctggcg gcggccccgg agcctcgcct cgtgtcgggc 1500 gtgaggccta gcgtggcttc cgccccgccg cgtgccaccg cggccgcgct ttgctgtctg 1560 cccggctgcc ctcgattgcc tgcccgcggc ccgggccaac aaagggaggg cgtggagctg 1620 gctggtaggg agccccgtag tccgcatgtc gggcagggag agcggcagca gtcggggggg 1680 ggaccgggcc cgcccgtccc gcagcacatg tccgacgccg cctggacggg tagcggcctg 1740 tgtcctgata aggcggccgg gcggtgggtt ttagatgccg ggttcaggtg gccccgggtc 1800 ccggcccggt ctggccagta ccccgtagtg gcttagctcc gaggagggcg agcccgcccg 1860 cccggcacca gttgcgtgcg cggaaagatg gccgctcccg ggccctgtag caaggagctc 1920 aaaatggagg acgcggcagc ccggcggagc ggggcgggtg agtcacccac acaaaggaag 1980 agggccttgc ccctcgccgg ccgctgcttc ctgtgacccc gtggtgtacc ggccgcactt 2040 cagtcacccc gggcgctctt tcggagcacc gctggcctcc gctgggggag gggatctgtc 2100 taatggcgtt ggagtttgct cacatttggt gggtggagac tgtagccagg ccagcctggc 2160 catggaagta attcttggaa tttgcccatt ttgagtttgg agcgaagctg attgacaaag 2220 ctgcttagcc gttcaaagtt tttttcttcc atttcaggtg ttgtgaaaac caccgctaat 2280 tcaaagcaag ccgccacc 2298 <210> 922 <211> 1953 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 922 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacattg attattgact agttattaat 840 agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac 900 ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa 960 tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt 1020 atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc 1080 ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat 1140 gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc 1200 ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc 1260 tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa 1320 aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg 1380 tctatataag cagagctcgt ttagtgaacc gtcagatcct cactctcttc cgcatcgctg 1440 tctgcgaggg ccagctgttg ggctcgcggt tgaggacaaa ctcttcgcgg tctttccagt 1500 actcttggat cggaaacccg tcggcctccg aacggtactc cgccaccgag ggacctgagc 1560 gagtccgcat cgaccggatc ggaaaacctc tcgagaaagg cgtctaacca gtcacagtcg 1620 caaggtaggc tgagcaccgt ggcgggcggc agcgggtggc ggtcggggtt gtttctggcg 1680 gaggtgctgc tgatgatgta attaaagtag gcggtcttga gacggcggat ggtcgaggtg 1740 aggtgtggca ggcttgagat ccagctgttg gggtgagtac tccctctcaa aagcgggcat 1800 tacttctgcg ctaagattgt cagtttccaa aaacgaggag gatttgatat tcacctggcc 1860 cgatctggcc atacacttga gtgacaatga catccacttt gcctttctct ccacaggtgt 1920 ccactcccag gtccaagttt aaacgccgcc acc 1953 <210> 923 <211> 1881 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 923 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacatct ggccgccata tactgagtca 840 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 900 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 960 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 1020 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgct gctgatgcgg 1080 ttttggcagt acaccaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc 1140 caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa 1200 tgtcgtaata accccgcccc gttgacgcaa atgggcggta ggcgtgtacg gtgggaggtc 1260 tatataagca gagctcgttt agtgaaccgt cagatcctca ctcactctct tccgcatcgc 1320 tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca aactcttcgc ggtctttcca 1380 gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg agggacctga 1440 gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt 1500 cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg gcggtcgggg ttgtttctgg 1560 cggaggtgct gctgatgatg taattaaagt aggcggtctt gagactgcgg atggtcgagg 1620 tgaggtgtgg caggcttgag atccagctgt tggggtgagt actccctctc aaaagcgggc 1680 attacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg 1740 cccgatctgg ccatacactt gagtgacaat gacatccact ttgcctttct ctccacaggt 1800 gtccactccc agcgtctcag gggagcttcc ttcttctttt tcctagaagc tcagaataaa 1860 cgctcaactt tggccgccac c 1881 <210> 924 <211> 1926 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 924 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacatct ggccgccata tactgagtca 840 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 900 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 960 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 1020 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc 1080 ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt 1140 cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga 1200 aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc 1260 attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaccg 1320 ccgtcgcagt cttgggtctg accacctcac tctcttccgc atcgctgtct gcgagggcca 1380 gctgttgggc tcgcggttga ggacaaactc ttcgcggtct ttccagtact cttggatcgg 1440 aaacccgtcg gcctccgaac ggtactccgc caccgaggga cctgagcgag tccgcatcga 1500 ccggatcgga aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga 1560 gcaccgtggc gggcggcagc gggtggcggt cggggttgtt tctggcggag gtgctgctga 1620 tgatgtaatt aaagtaggcg gtcttgagac tgcggatggt cgaggtgagg tgtggcaggc 1680 ttgagatcca gctgttgggg tgagtactcc ctctcaaaag cgggcattac ttctgcgcta 1740 agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccga tctggccata 1800 cacttgagtg acaatgacat ccactttgcc tttctctcca caggtgtcca ctcccagcgt 1860 ctcaggggag cttccttctt ctttttccta gaagctcaga ataaacgctc aactttggcc 1920 gccacc 1926 <210> 925 <211> 1713 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 925 taatcgagta cgatagccgg ctaatcagcc ataccacatt tgtagaggtt ttacttgctt 60 taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 120 ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 180 caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 240 cttatcatgt ctggaattcg gacggtgact gcagtgaata ataaaatgtg tgtttgtccg 300 aaatacgcgt tttgagattt ctgtcgccga ctaaattcat gtcgcgcgat agtggtgttt 360 atcgccgata gagatggcga tattggaaaa atcgatattt gaaaatatgg catattgaaa 420 atgtcgccga tgtgagtttc tgtgtaactg atatcgccat ttttccaaaa gtgatttttg 480 ggcatacgcg atatctggcg atagcgctta tatcgtttac gggggatggc gatagacgac 540 tttggtgact tgggcgattc tgtgtgtcgc aaatatcgca gtttcgatat aggtgacaga 600 cgatatgagg ctatatcgcc gatagaggcg acatcaagct ggcacatggc caatgcatat 660 cgatctatac attgaatcaa tattggccat tagccatatt attcattggt tatatagcat 720 aaatcaatat tggctattgg ccattgcata cgttgtatcc atatcataat atgtacattt 780 atattggctc atgtccaaca ttaccgccat gttgacatct ggccgccata tactgagtca 840 ttagggactt tccaatgggt tttgcccagt acataaggtc aataggggtg aatcaacagg 900 aaagtcccat tggagccaag tacactgagt caatagggac tttccattgg gttttgccca 960 gtacaaaagg tcaatagggg gtgagtcaat gggtttttcc cattattggc acgtacataa 1020 ggtcaatagg ggtgagtcat tgggtttttc cagccaattt ataaaacgcc atgtactttc 1080 ccaccattga cgtcaatggg ctattgaaac taatgcaacg tgacctttaa acggtacttt 1140 cccatagctg attaatggga aagtaccgtt ctcgagccaa tacacgtcaa tgggaagtga 1200 aagggcagcc aaaacgtaac accgccccgg ttttcccctg gaaattccat attggcacgc 1260 attctattgg ctgagctgcg ttctacgtgg gtataagagg cgcgaccagc gtcggtaccg 1320 ccgtcgcagt cttgggtctg accacatcca cgctgttttg acctccatag tggacaccgg 1380 gaccgatcca gcctccgcgg ccgggaacgg tgcattggaa cgcggattcc ccgtgccaag 1440 agtgaccctg gcagaactcg gtaagtctgt tgacatgtat gtgatgtata ctaacctgca 1500 tgggacgtgg atttacttgt gtatgtcaga tagagtaaag attaactctt gcatgtgagc 1560 ggggcatcga gatagcgata aatgagtcag gaggacggat acttatatgt gttgttatcc 1620 tcctctacag tcaaacagat taagcgtctc aggggagctt ccttcttctt tttcctagaa 1680 gctcagaata aacgctcaac tttggccgcc acc 1713 <210> 926 <211> 2158 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 926 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaacctctc 660 ccggccagag gagcaaggta tgcgggaggc gaccaggagg atagcggggc tgacgtcggg 720 aggtggcctc cgtgggaagg acacccggat cttgacacag ccttggcagc ggagtcagga 780 agagtagggg taggttctgg acgccctctt ggccagctca tcgccgcccc accctctgct 840 ggagcacaga gtaattcata caaaaggagg gatcgccttc gcaaggggag agcccaggga 900 ccgtccctaa attctcacag acccaaatcc ctgtagccgc cccacgacag cgcgaggagc 960 atgcgcccag ggctgagcgc gggtagatca gagcacacaa gctcacagtc cccggcggtg 1020 gggggagggg cgcgctgagc gggggccagg gagctggcgc ggggcaaact gggaaagtgg 1080 tgtcgtgtgc tggctccgcc ctcttcccga gggtggggga gaacggtata taagtgcggt 1140 agtcgccttg gacgttcttt ttcgcaacgg gtttgccgtc agaacgcagg tgagtggcgg 1200 gtgtggcttc cgcgggcccc ggagctggag ccctgctctg agcgggccgg gctgatatgc 1260 gagtgtcgtc cgcagggttt agctgtgagc attcccactt cgagtggcgg gcggtgcggg 1320 ggtgagagtg cgaggcctag cggcaacccc gtagcctcgc ctcgtgtccg gcttgaggcc 1380 tagcgtggtg tccgccgccg cgtgccactc cggccgcact atgcgttttt tgtccttgct 1440 gccctcgatt gccttccagc agcatgggct aacaaaggga gggtgtgggg ctcactctta 1500 aggagcccat gaagcttacg ttggatagga atggaagggc aggaggggcg actggggccc 1560 gcccgccttc ggagcacatg tccgacgcca cctggatggg gcgaggcctg tggctttccg 1620 aagcaatcgg gcgtgagttt agcctacctg ggccatgtgg ccctagcact gggcacggtc 1680 tggcctggcg gtgccgcgtt cccttgcctc ccaacaaggg tgaggccgtc ccgcccggca 1740 ccagttgctt gcgcggaaag atggccgctc ccggggccct gttgcaagga gctcaaaatg 1800 gaggacgcgg cagcccggtg gagcgggcgg gtgagtcacc cacacaaagg aagagggcct 1860 tgcccctcgc cggccgctgc ttcctgtgac cccgtggtct atcggccgca tagtcacctc 1920 gggcttctct tgagcaccgc tcgtcgcggc ggggggaggg gatctaatgg cgttggagtt 1980 tgttcacatt tggtgggtgg agactagtca ggccagcctg gcgctggaag tcattcttgg 2040 aatttgcccc tttgagtttg gagcgaggct aattctcaag cctcttagcg gttcaaagtt 2100 tttttcttcc atttcaggtg ttgtgaaagc caccgctaat tcaaagcaag ccgccacc 2158 <210> 927 <211> 1752 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 927 ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac 60 tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca 120 ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aatacaatag 180 caggcatgct ggggatgcgg tgggctctat gggtacccag gtgctgaaga attgacccgg 240 ttcctcctgg gatattatcc ctaatacttg ccaccccact cttaatcagt ggtggaagaa 300 cggtgtcaga actgtttgtt tcaattggcc atttaagttt agtagtaaaa gactggttaa 360 tgataacaat gcatcgtaaa accttcagaa ggaaaggaga atgttttgtg gaccactttg 420 gttttctttt ttgcgtgtgg cagttttaag ttattagttt ttaaaatcag tactttttaa 480 tggaaacaac ttgaccaaaa atttgtcaca gaattttgag atccattaaa aaagttaaat 540 gagaaacctg tgtgttcctt tggtcaacac cgagacattt aggtgaaaga attcgtttat 600 cggccaccga ggccaagatc tggccgccag ccaagatctg gccgccatat actgagtcat 660 tagggacttt ccaatgggtt ttgcccagta cataaggtca ataggggtga atcaacagga 720 aagtcccatt ggagccaagt acactgagtc aatagggact ttccattggg ttttgcccag 780 tacaaaaggt caataggggg tgagtcaatg ggtttttccc attattggca cgtacataag 840 gtcaataggg gtgagtcatt gggtttttcc agccaattta taaaacgcca tgtactttcc 900 caccattgac gtcaatgggc tattgaaact aatgcaacgt gacctttaaa cggtactttc 960 ccatagctga ttaatgggaa agtaccgttc tcgagccaat acacgtcaat gggaagtgaa 1020 agggcagcca aaacgtaaca ccgccccggt tttcccctgg aaattccata ttggcacgca 1080 ttctattggc tgagctgcgt tctacgtggg tataagaggc gcgaccagcg tcggtaggga 1140 ccggtttgcc gccagaacac agtcagatcc tcactctctt ccgcatcgct gtctgcgagg 1200 gccagctgtt gggctcgcgg ttgaggacaa actcttcgcg gtctttccag tactcttgga 1260 tcggaaaccc gtcggcctcc gaacggtact ccgccaccga gggacctgag cgagtccgca 1320 tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg 1380 ctgagcaccg tggcgggcgg cagcgggtgg cggtcggggt tgtttctggc ggaggtgctg 1440 ctgatgatgt aattaaagta ggcggtcttg agacggcgga tggtcgaggt gaggtgtggc 1500 aggcttgaga tccagctgtt ggggtgagta ctccctctca aaagcgggca ttacttctgc 1560 gctaagattg tcagtttcca aaaacgagga ggatttgata ttcacctggc ccgatctggc 1620 catacacttg agtgacaatg acatccactt tgcctttctc tccacaggtg tccactccca 1680 ggtccaagtt taaacagctt gcttgttctt tttgcagaag ctcagaataa acgctcaact 1740 ttggccgcca cc 1752 <210> 928 <211> 2433 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 928 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 60 actcggaaga acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 120 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 180 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 240 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 300 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 360 agctgtccct cttctcttat ggagatcata ttacccctaa cacctgccac cccagtctta 420 atcagtggtg gaagaactct cagaactgtt tgtctcaatt ggccatttaa gtttaatagt 480 gaaagactgg ttaatgataa caatgcatcg gaaaaccttc aggaggaaag gagaatgttt 540 tgtggaacat ttttgtgtgt gtggcagttt taagttatta gttttcaaaa tcagtacttt 600 ttaatggaaa caacttgacc aaaaatctgt cacagaattt tgaacccatt aaaagccgcc 660 atatactgag tcattaggga ctttccaatg ggttttgccc agtacataag gtcaataggg 720 gtgaatcaac aggaaagtcc cattggagcc aagtacactg agtcaatagg gactttccat 780 tgggttttgc ccagtacaaa aggtcaatag ggggtgagtc aatgggtttt tcccattatt 840 ggcacgtaca taaggtcaat aggggtgagt cattgggttt ttccagccaa tttataaaac 900 gccatgtggc ggggctgacg tcgggaggtg gcctccacgg gaagggacac ccggatctcg 960 acacagcctt ggcagtggag tcaggaaggg taggacagat tctggacgcc ctcttggcca 1020 gtcctcaccg ccccaccccc gatggagccg agagtaattc atacaaaagg agggatcgcc 1080 ttcgcccctg ggaatcccag ggaccgtcgc taaattctgg ccggcctccc agcccggaac 1140 cgctgtgccc gcccagcgcg gcgggaggag cctgcgccta gggcggatcg cgggtcggcg 1200 ggagagcaca agcccacagt ccccggcggt gggggagggg cgcgctgagc gggggcccgg 1260 gagccagcgc ggggcaaact gggaaagtgg tgtcgtgtgc tggctccgcc ctcttcccga 1320 gggtggggga gaacggtata aaagtgcggt agtcgcgttg gacgttcttt ttcgcaacgg 1380 gtttgccgtc agaacgcagg tgagtggcgg gtgtggcctc cgcgggcccg ggctccctcc 1440 tttgagcggg gtcggaccgc cgtgcgggtg tcgtcggccg ggcttctctg cgagcgttcc 1500 cgccctggat ggcgggctgt gcgggagggc gaggggggga ggcctggcgg cggccccgga 1560 gcctcgcctc gtgtcgggcg tgaggcctag cgtggcttcc gccccgccgc gtgccaccgc 1620 ggccgcgctt tgctgtctgc ccggctgccc tcgattgcct gcccgcggcc cgggccaaca 1680 aagggagggc gtggagctgg ctggtaggga gccccgtagt ccgcatgtcg ggcagggaga 1740 gcggcagcag tcgggggggg gaccgggccc gcccgtcccg cagcacatgt ccgacgccgc 1800 ctggacgggt agcggcctgt gtcctgataa ggcggccggg cggtgggttt tagatgccgg 1860 gttcaggtgg ccccgggtcc cggcccggtc tggccagtac cccgtagtgg cttagctccg 1920 aggagggcga gcccgcccgc ccggcaccag ttgcgtgcgc ggaaagatgg ccgctcccgg 1980 gccctgtagc aaggagctca aaatggagga cgcggcagcc cggcggagcg gggcgggtga 2040 gtcacccaca caaaggaaga gggccttgcc cctcgccggc cgctgcttcc tgtgaccccg 2100 tggtgtaccg gccgcacttc agtcaccccg ggcgctcttt cggagcaccg ctggcctccg 2160 ctgggggagg ggatctgtct aatggcgttg gagtttgctc acatttggtg ggtggagact 2220 gtagccaggc cagcctggcc atggaagtaa ttcttggaat ttgcccattt tgagtttgga 2280 gcgaagctga ttgacaaagc tgcttagccg ttcaaaggta ttcttcgaac ttttttttta 2340 aggtgttgtg aaaaccaccg ctaattcaaa tccaacagct tgcttgttct ttttgcagaa 2400 gctcagaata aacgctcaac tttggccgcc acc 2433 <210> 929 <211> 1767 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 929 atggccagag gactaacaga tttagaaata aatcaaattt tggaattgga agacgtagaa 60 aatgacgtaa tttttgacga aagtggagac gagtccgatc atgttagtat aagggttgaa 120 tcggacacgg aagaggtaga aatacctact cttgagcctc aacaaggaag tagtgacagc 180 gaaaatgatc agcctttgtc aaatctggct cgtagatctt tttataaagg caaagacaac 240 acaatttgga accgtgctcc tccgaatccc cgcgtccgca caagaagtga aaatatagtc 300 acagggacac caggagttaa acgtcaagca aaaaatgctc ttcttgaact ggattgtttt 360 catctctttg tcaacgaaag tatactatct gttattctag aacacaccaa tcacaagatt 420 cggagtgaga gacagggtaa gaatacttcc aatgaatatg cttattcaga gactactttg 480 acagaactta gagctgtcat tggactactt tacttagctg gactattcaa atctgggaga 540 caaaacctac aggatttatg ggcatctgac ggaacgggga tcgagatatt tccaatgaca 600 atgagtctga gaagattcgc gtttattgtg aactgtttga gatttgacga tagtgatacg 660 cgcgaagaaa gagcagctat tgatagattg gcacccatta gacagatcta tgaagaattt 720 gtaaaaaatt gcaaggacgt ttacacacca tacgaaaatt taactattga tgaagaactc 780 gtggcatttc gtggtcgatg caaatttcgg cagtatctac ctaataaacc agcgaagtat 840 gggattaaaa ttatagccct agtagacgct tatacttact attccttgaa tatggaaata 900 tatgcagggg accagcccga tgggccgtac aaagtgagta ataagccaca tgatgttgtc 960 gatcgcattg tccagcccat ttctcaaaca ggccgaaatg taaccatgga caattggttt 1020 acaagctatc ccacatacgc ccacctatta aaaaaccata aactgaccgc agttgggact 1080 atgaagagta ataaaacctg tatcccacca aaatttcgtg aacgtcgtga aataaacacc 1140 tcgctcttcg ggtttcaaga tgatttcact attgtatctt acataccgaa acgcaacaaa 1200 aatgttttca tgctgtcatc tctccatcat gatagtgaga tagattctga aacaggagaa 1260 cagcaaaaac cctcaattat aacgttttat aataaaacca agagtggagt agacaatgtg 1320 gacaagctaa taaggacata tgacgtatcg cgaaattcaa ggagatggcc gctaacaatt 1380 tttttctgga ttctcaatac agctgggata aatgcaaaaa tagtacaaat gctgaacagc 1440 tccgataata ctccaaccag aagagcattc ataaaaaaat taggcatgtc attgattgca 1500 ccacatcaag ctgaaagaaa aacaaattct aaaattccag tgagtctccg caaacgaatt 1560 ggctctcatc ttggtgaatc atcagcgtca cctgccaaga tacctaatgt tggcgtgaag 1620 aaacgatgct atatatgccc agtgaaaaaa gataggaagt ctaaatacat ttgtatatcc 1680 tgtactagtc acatttgttt ggagcatgca aatttcgtat gcgaaaattg tcgccgaaat 1740 gaagaagaaa attcagatag ttcctaa 1767 <210> 930 <211> 1764 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 930 atggctaggg gactgacgga tctggaaatc aaccagatcc tggaactcga ggatgtggag 60 aacgatgtca tcttcgacga gtccggcgat gaatccgacc atgtgtcgat ccgggtggag 120 agcgacaccg aagaggtcga gattccaact ttggaaccgc aacagggtag tagcgattcc 180 gaaaacgatc aacctctctc caacctggcc cggcgcagct tctacaaggg aaaggataac 240 accatctgga accgggctcc ccctaacccc cgcgtccgga cctcgtcgga aaacatcgtg 300 accggcactc ctggagtgaa gagacaggcc aagaatgccc tcctcgagct cgactgcttc 360 cacttgtttg tgaacgaatc cattctgtcc gtcatcctcg agcacacgaa ccacgagatc 420 cgctcagagc gacagggaaa gaacacctcc aacgaatacg cttatagcga aaccaccttg 480 actgaactgc gggccgtgat cggacttctg tacctcgcgg gcctgttcaa gagcggacgg 540 cagaatctgc aagacctgtg ggcgtccgac ggtaccggta tcgagatatt ccggatgact 600 atgtcactgc ggcggttcgc cttcatcgtg aactgtctgc ggttcgacga ctccgatacc 660 cgcgaggaaa gggccgcaat cgacaggctg gccccgatta gacagatcta cgaagagttc 720 gtgaagaact gcaaagacgt gtacactcct tacgaaaacc tgaccatcga cgaagaactc 780 gtggcgttcc gcggacgctg caaattcaga cagtacctcc ctaacaagcc cgcgaaatac 840 gggatcaaga tcatcgccct ggtcgatgcg tacacgtact attcattgaa catggaaatc 900 tacgccggcc ggcagccgga cggcccatac aaagtgtcaa acaagcccca cgatgtggtg 960 gacaggattg tgcagccaat ctcgcaaact ggccggaacg tcaccatgga caattggttc 1020 acatcctacc ccacctacgc ccatcttctg aagaaccaca agctgaccgc cgtggggacc 1080 atgaagtcca acaagacttg catcccgcct aagtttcgcg agcgccgcga gatcaacact 1140 tcccttttcg gattccaaga tgacttcact attgtgtcct acatcccgaa gcgcaacaag 1200 aacgtgttca tgcttagctc cctgcatcac gactcggaaa ttgacagcga aaccggggag 1260 cagcagaagc cttccattat cactttttac aacaagacca agagcggggt ggacaacgtc 1320 gacaagctga ttcggaccta cgacgtgtcc cggaactcca gacgctggcc gctgaccatc 1380 ttcttctgga ttctgaacac tgccggcatc aacgccaaga ttgtgcagat gctgaattcg 1440 tccgataaca cccctacccg gagagctttt atcaagaagc tcggaatgtc actgattgca 1500 ccgcatcagg ccgagagaaa gaccaactcc aagatccccg tgtccctgcg gaagcggatt 1560 ggttcccacc tgggagagtc gagcgccagc ccagcgaaga ttccgaacgt cggcgtcaag 1620 aagcgctgtt acatctgccc cgtgaagaag gaccggaagt cgaagtacat ctgcatttct 1680 tgtacctccc acatctgcct ggaacacgcc aatttcgtgt gcgagaactg caggcgcaac 1740 gaagaagaga actccgacag ctcg 1764 <210> 931 <211> 1764 <212> DNA <213> Artificial sequence <220> <223> Synthetic <400> 931 atggctaggg gactgacgga tctggaaatc aaccagatcc tggaactcga ggatgtggag 60 aacgatgtca tcttcgacga gtccggcgat gaatccgacc atgtgtcgat ccgggtggag 120 agcgacaccg aagaggtcga gattccaact ttggaaccgc aacagggtag tagcgattcc 180 gaaaacgatc aacctctctc caacctggcc cggcgcagct tctacaaggg aaaggataac 240 accatctgga accgggctcc ccctaacccc cgcgtccgga cctcgtcgga aaacatcgtg 300 accggcactc ctggagtgaa gagacaggcc aagaatgccc tcgacgagct cgactgcttc 360 cacttgtttg tgaacgaatc cattctgtcc gtcatcctcg agcacacgaa ccacgagatc 420 cgctcagagc gacagggaaa gaacacctcc aacgaatacg cttatagcga aaccaccttg 480 actgaactgc gggcctttat cggacttctg tacctcgcgg gcctgttcaa gagcaaccgg 540 cagaatctgc aagacctgtg ggcgtccgac ggtaccggta tcgagatatt ccggatgact 600 atgtcacggc ggcggttcgc cttcatcgtg aactgtctgc ggttcgacga ctccgatacc 660 cgcgaggaaa gggccgcaat cgacaggctg gccccgatta gacagatcta cgaagagttc 720 gtgaagaact gcaaagacgt gtacactcct tacgaaaacc tgaccatcga cgaagaactc 780 gtggcgttcc gcggacgctg caaattcaga cagtacctcc ctaacaagcc cgcgaaatac 840 gggatcaaga tcatcgccct ggtcgatgcg tacacgtact attcattgaa catggaaatc 900 tacgccggcc ggcagccgga cggcccatac aaagtgtcaa acaagcccca cgatgtggtg 960 gacaggattg tgcagccaat ctcgcaaact ggccggaacg tcaccatgga caattggttc 1020 acatcctacc ccacctacgc ccatcttctg aagaaccaca agctgaccgc cgtggggacc 1080 atgaagtcca acaagcggtg catcccgcct aagtttcgcg agcgccgcga gatcaacact 1140 tcccttttcg gattccaaga tgacttcact attgtgtcct acatcccgaa gcgcaacaag 1200 aacgtgttca tgcttagctc cctgcatcac gactcggaaa ttgacagcga aaccggggag 1260 cagcagaagc cttccattat cactttttac aacaagacca agagcggggt ggacaacgtc 1320 gacaagctga ttcggaccta cgacgtgtcc cggaactcca gacgctggcc gctgaccatc 1380 ttcttctgga ttctgaacac tgccggcatc aacgccaaga ttgtgcagat gctgaattcg 1440 tccgataaca cccctacccg gagagctttt atcaagaagc tcggaatgtc actgattgca 1500 ccgcatcagg ccgagagaaa gaccaactcc aagatccccg tgtccctgcg gaagcggatt 1560 ggttcccacc tgggagagtc gagcgccagc ccagcgaaga ttccgaacgt cggcgtcaag 1620 aagcgctgtt acatctgccc cgtgaagaag gaccggaagt cgaagtacat ctgcatttct 1680 tgtacctccc acatctgcct ggaacacgcc aatttcgtgt gcgagaactg caggcgcaac 1740 gaagaagaga actccgacag ctcg 1764

Claims (49)

  1. 이종성 프로모터에 작동가능하게 연결된, 트랜스포사제를 인코딩하는 오픈 리딩 프레임을 포함하는 폴리뉴클레오티드로서, 이의 아미노산 서열은 SEQ ID NO: 18과 적어도 90% 동일한, 폴리뉴클레오티드.
  2. 제1항에 있어서, 트랜스포사제가 SEQ ID NO: 18의 서열과 비교해 표 1의 C 열 및 D 열에 제시된 바와 같은 돌연변이를 포함하는, 폴리뉴클레오티드.
  3. 제2항에 있어서, 트랜스포사제가 SEQ ID NO: 18의 서열과 비교해 79, 95, 115, 116, 121, 139, 166, 179, 187, 198, 203, 211, 238, 273, 304, 329, 345, 362, 366, 408, 416, 435, 458, 475, 483, 491, 529, 540, 560 및 563으로부터 선택되는 아미노산 위치에서 돌연변이를 포함하는, 폴리뉴클레오티드.
  4. 제3항에 있어서, 트랜스포사제가 SEQ ID NO: 18의 서열과 비교해 D79N, R95S, L115D, E116P, H121Q, K139E, V166F, G179N, W187F, P198R, L203R, N211R, E238D, L273M, L273I, D304R, D304K, Q329G, T345L, K362R, T366R, L408M, S416E, S435G, L458M, V475I, N483K, I491M, A529P, K540R, S560K 및 S563K로부터 선택되는 돌연변이를 포함할 수 있으며, 트랜스포사제는 상기 군으로부터 선택되는 적어도 2, 3, 4 또는 5개를 임의적으로 포함하는, 폴리뉴클레오티드.
  5. 제2항에 있어서, 트랜스포사제의 아미노산 서열이 SEQ ID NO: 96-170으로부터 선택되는, 폴리뉴클레오티드.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 트랜스포사제가 SEQ ID NO: 192로부터 트랜스포존을 절제하거나 전위시킬 수 있는, 폴리뉴클레오티드.
  7. 제6항에 있어서, 트랜스포사제의 절제 활성 또는 전위 활성이 SEQ ID NO: 39의 활성보다 적어도 2배 더 높고, 임의적으로 2 내지 50배 더 높은, 폴리뉴클레오티드.
  8. 제1항 내지 제7항 중 어느 한 항에 있어서, 프로모터가 시험관내 전사 반응에서 활성인, 폴리뉴클레오티드.
  9. 제1항 내지 제7항 중 어느 한 항에 있어서, 프로모터가 진핵 세포에서 활성인, 폴리뉴클레오티드.
  10. 제9항에 있어서, 진핵 세포가 포유동물 세포이고, 임의적으로 오픈 리딩 프레임의 코돈이 포유동물 세포 발현을 위해 선택되는, 폴리뉴클레오티드.
  11. 아미노산 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리펩티드를 인코딩하는 단리된 mRNA로서, mRNA 서열은 mRNA와 SEQ ID NO: 781 사이의 상응하는 위치에서 SEQ ID NO: 929와 비교해 적어도 10개의 동의 코돈 차이를 포함하며, 임의적으로 상응하는 위치에서 mRNA의 코돈은 포유동물 세포 발현을 위해 선택되는, 단리된 mRNA.
  12. 제1항 내지 제11항 중 어느 한 항에 있어서, 오픈 리딩 프레임이 트랜스포사제에 융합된 핵 국소화 서열을 추가로 인코딩하는, 폴리뉴클레오티드.
  13. 제1항 내지 제12항 중 어느 한 항에 있어서, 오픈 리딩 프레임이 트랜스포사제에 융합된 이종성 DNA 결합 도메인을 추가로 인코딩하는, 폴리뉴클레오티드.
  14. 제13항에 있어서, DNA 결합 도메인이 Crispr Cas 시스템, 또는 아연 핑거 단백질, 또는 TALE 단백질로부터 유래되는, 폴리뉴클레오티드.
  15. 서열이 SEQ ID NO: 18과 적어도 90% 동일한 폴리펩티드를 인코딩하는 비-자연 발생 폴리뉴클레오티드로서, 폴리뉴클레오티드 서열은 폴리뉴클레오티드와 SEQ ID NO: 929 사이의 상응하는 위치에서 SEQ ID NO: 929와 비교해 적어도 10개의 동의 코돈 차이를 포함하며, 임의적으로 상응하는 위치에서 폴리뉴클레오티드의 코돈은 포유동물 세포 발현을 위해 선택되는, 비-자연 발생 폴리뉴클레오티드.
  16. 제1항 내지 제15항 중 어느 한 항의 폴리뉴클레오티드에 의해 인코딩된 비-자연 발생 폴리펩티드.
  17. 이종성 폴리뉴클레오티드에 측접한 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 트랜스포존.
  18. 제17항에 있어서, 이종성 폴리뉴클레오티드의 한 측에서 SEQ ID NO: 13과 적어도 90% 동일한 서열 및 다른 측에서 SEQ ID NO: 16과 적어도 90% 동일한 서열을 추가로 포함하는, 트랜스포존.
  19. 제17항 또는 제18항에 있어서, 이종성 폴리뉴클레오티드가 진핵 세포에서 활성인 이종성 프로모터를 포함하는, 트랜스포존.
  20. 제19항에 있어서, 프로모터가 i) 오픈 리딩 프레임; ii) 선택가능 마커를 인코딩하는 핵산; iii) 카운터-선택가능 마커를 인코딩하는 핵산; iii) 조절 단백질을 인코딩하는 핵산; iv) 억제성 RNA를 인코딩하는 핵산 중 적어도 하나 이상에 작동가능하게 연결되는, 트랜스포존.
  21. 제19항에 있어서, 이종성 프로모터가 SEQ ID NO: 474-558로부터 선택되는 서열을 포함하는, 트랜스포존.
  22. 제17항 내지 제21항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 진핵 세포에서 활성인 이종성 인핸서를 포함하는, 트랜스포존.
  23. 제22항에 있어서, 이종성 인핸서가 SEQ ID NO: 453-473으로부터 선택되는, 트랜스포존.
  24. 제17항 내지 제23항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 진핵 세포에서 스플라이싱 가능한 이종성 인트론을 포함하는, 트랜스포존.
  25. 제24항에 있어서, 이종성 인트론의 뉴클레오티드 서열이 SEQ ID NO: 561-621로부터 선택되는, 트랜스포존.
  26. 제17항 내지 제25항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 격리자(insulator) 서열을 포함하는, 트랜스포존.
  27. 제26항에 있어서, 격리자의 핵산 서열이 SEQ ID NO: 435-441로부터 선택되는, 트랜스포존.
  28. 제17항 내지 제27항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 선택가능 마커를 포함하거나 인코딩하는, 트랜스포존.
  29. 제28항에 있어서, 선택가능 마커가 글루타민 합성효소, 디하이드로폴레이트 환원효소, 퓨로마이신 아세틸트랜스퍼라제 효소, 블라스티시딘 아세틸트랜스퍼라제 효소, 하이그로마이신 B 포스포트랜스퍼라제 효소, 아미노글리코시드 3'-포스포트랜스퍼라제 효소 및 형광 단백질로부터 선택되는, 트랜스포존.
  30. 게놈이 이종성 폴리뉴클레오티드에 측접되는 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 진핵 세포.
  31. 제30항에 있어서, 세포가 동물 세포인, 진핵 세포.
  32. 제31항에 있어서, 세포가 포유동물 세포인, 동물 세포.
  33. 제32항에 있어서, 세포가 설치류 세포인, 포유동물 세포.
  34. 제32항에 있어서, 세포가 인간 세포인 포유동물 세포.
  35. 제17항 내지 제29항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 2개의 오픈 리딩 프레임을 포함하고, 이들 각각은 개별 프로모터에 작동가능하게 연결되는, 트랜스포존.
  36. 제35항에 있어서, 이종성 폴리뉴클레오티드가 SEQ ID NO: 745-928로부터 선택되는 서열을 추가로 포함하는, 트랜스포존.
  37. 진핵 세포에 트랜스포존을 통합시키는 방법으로서, 상기 방법은
    a. 이종성 폴리뉴클레오티드에 측접한 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 트랜스포존을 세포에 도입하는 단계,
    b. 서열이 SEQ ID NO: 18과 적어도 90% 동일한 트랜스포사제를 세포에 도입하는 단계로서, 트랜스포사제가 트랜스포존을 전위시켜 이종성 폴리뉴클레오티드에 측접되는 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 게놈을 생성하는 단계를 포함하는 방법.
  38. 제37항에 있어서, 트랜스포사제가 트랜스포사제를 인코딩하는 폴리뉴클레오티드로서 도입되는, 방법.
  39. 제38항에 있어서, 트랜스포사제를 인코딩하는 폴리뉴클레오티드가 mRNA 분자인, 방법.
  40. 제38항에 있어서, 트랜스포사제를 인코딩하는 폴리뉴클레오티드가 DNA 분자인, 방법.
  41. 제37항에 있어서, 트랜스포사제가 단백질로서 도입되는, 방법.
  42. 제37항 내지 제41항 중 어느 한 항에 있어서, 이종성 폴리뉴클레오티드가 선택가능 마커를 인코딩하고, 방법은
    c. 선택가능 마커를 포함하는 세포를 선택하는 단계를 추가로 포함하는, 방법.
  43. 제37항에 있어서, 세포가 동물 세포인, 방법.
  44. 제43항에 있어서, 세포가 포유동물 세포인, 동물 세포.
  45. 제44항에 있어서, 세포가 설치류 세포인, 포유동물 세포.
  46. 제44항에 있어서, 세포가 인간 세포인, 포유동물 세포.
  47. 이종성 폴리뉴클레오티드에 측접되는 SEQ ID NO: 9 및 SEQ ID NO: 10을 포함하는 게놈을 갖는 진핵 세포를 배양하는 단계를 포함하는 폴리펩티드를 발현시키는 방법으로서, 폴리뉴클레오티드가 발현되는 방법.
  48. 제47항에 있어서, 배양 배지로부터 폴리펩티드를 정제하는 단계를 추가로 포함하는, 방법.
  49. 제47항 또는 제48항에 있어서, 정제된 폴리펩티드를 약학적 조성물에 혼입시키는 단계를 추가로 포함하는, 방법.
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