CN1371416B - 人ctla-4抗体及其应用 - Google Patents
人ctla-4抗体及其应用 Download PDFInfo
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- CN1371416B CN1371416B CN008120374A CN00812037A CN1371416B CN 1371416 B CN1371416 B CN 1371416B CN 008120374 A CN008120374 A CN 008120374A CN 00812037 A CN00812037 A CN 00812037A CN 1371416 B CN1371416 B CN 1371416B
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- A01K2267/01—Animal expressing industrially exogenous proteins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
小鼠 | 血清IgM(μg/ml) | IgH链基因型 |
42 | <0.002 | CMD/JHD |
43 | 196 | +/JHD |
44 | <0.002 | CMD/JHD |
45 | 174 | +/JHD |
129×BL6F1 | 153 | +/+ |
JHD | <0.002 | JHD/JHD |
杂交瘤 | ka(1/Ms) | kd(1/s) | Ka(1/M) |
10D1.3 | 4.1×105 | 1.0×10-4 | 4×109 |
4B6.12 | 5.1×105 | 1.3×10-4 | 4×109 |
11E8 | 4.3×105 | 1.8×10-4 | 2×109 |
链 | HuMAb | CDRI | SEQIDNO: | CDR2 | SEQ IDNO: | CDR3 | SEQIDNO: |
轻链 | 10D14B61E2 | RASQSVGSSYLARASQSVSSSFLARASQGISSWLA | 242526 | GAFSRATGASSRATAASSLQS | 293031 | QQYGSSPWTQQYGSSPWTQQYNSYPPT | 353536 |
重链 | 10D14B61E2 | SYTMHSYTMHSYGMH | 272728 | FISYDGNNKYYADSVKGFISYDGSNKHYADSVKGVIWYDGSNKYYADSVKG | 323334 | TGWLGPFDYTGWLGPFDYAPNYIGAFDV | 373738 |
物种 | 同型Ig对照的反应性(MFI) | 10D1的反应性(MFI) |
人CTLA4 | 3 | 662 |
猕猴CTLA4 | 4 | 606 |
鼠CTLA4(阴性对照) | 5 | 5 |
时间点 | 猴#1 | 猴#2 |
第一次服药前 | 0.0(μg/ml血浆) | 0.0(μg/ml血浆) |
第4天,第二次服药前 | 17.4(μg/ml血浆) | 43.6(μg/ml血浆) |
第7天,第三次服药前 | 83.6(μg/ml血浆) | 97.3(μg/ml血浆) |
第14天 | 90.2(μg/ml血浆) | 70.9(μg/ml血浆) |
时间点 | 猴#1 | 猴#2 |
第一次剂量前 | %CD3=61,%CD20=16%CD4=43,%CD8=50%CD25≤1,%CD29=41%CD69≤1,%HLA-DR=4 | %CD3=54,%CD20=22%CD4=59,%CD8=36%CD25≤1,%CD29=29%CD69≤1,%HLA-DR=1 |
第4天,第二次剂量前 | %CD3=58,%CD20=13%CD4=38,%CD8=52%CD25≤1,%CD29=52%CD69≤1,%HLA-DR=2 | %CD3=56,%CD20=16%CD4=62,%CD8=37%CD25≤1,%CD29=36%CD69≤1,%HLA-DR≤1 |
第7天,第三次剂量前 | %CD3=59,%CD20=15%CD4=47,%CD8=59%CD25=2,%CD29=44%CD69=1,%HLA-DR=4 | %CD3=51,%CD20=17%CD4=51,%CD8=39%CD25=1,%CD29=39%CD69=1,%HLA-DR=2 |
第14天 | %CD3=64,%CD20=14%CD4=49,%CD8=44%CD25=1,%CD29=44%CD69≤1,%HLA-DR=15 | %CD3=59,%CD20=20%CD4=60,%CD8=35%CD25≤1,%CD29=34%CD69≤1,%HLA-DR=1 |
组号 | 雄性/雌性数目 | 剂量水平(mg/kg) | 剂量体积(ml/kg) | 剂量溶液浓度(mg/ml) |
1 | 2/0 | 3 | 0.6 | 5.0 |
2 | 2/2 | 10 | 2.0 | 5.0 |
Claims (55)
Priority Applications (1)
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CN201210037538.0A CN102766210B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Applications Claiming Priority (3)
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US15045299P | 1999-08-24 | 1999-08-24 | |
US60/150,452 | 1999-08-24 | ||
PCT/US2000/023356 WO2001014424A2 (en) | 1999-08-24 | 2000-08-24 | Human ctla-4 antibodies and their uses |
Related Child Applications (1)
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CN201210037538.0A Division CN102766210B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN1371416A CN1371416A (zh) | 2002-09-25 |
CN1371416B true CN1371416B (zh) | 2012-10-10 |
Family
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CN008120374A Expired - Lifetime CN1371416B (zh) | 1999-08-24 | 2000-08-24 | 人ctla-4抗体及其应用 |
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US (1) | US6984720B1 (zh) |
EP (4) | EP1212422B1 (zh) |
JP (4) | JP4093757B2 (zh) |
KR (3) | KR20020047132A (zh) |
CN (2) | CN102766210B (zh) |
AT (1) | ATE354655T1 (zh) |
AU (3) | AU784012B2 (zh) |
BE (1) | BE2012C001I2 (zh) |
CA (2) | CA2589418A1 (zh) |
CY (2) | CY1107628T1 (zh) |
DE (2) | DE60033530T2 (zh) |
DK (1) | DK1212422T3 (zh) |
ES (1) | ES2282133T3 (zh) |
FR (1) | FR12C0004I2 (zh) |
HK (1) | HK1048831A1 (zh) |
IL (3) | IL148079A0 (zh) |
LU (1) | LU91928I2 (zh) |
MX (1) | MXPA02001911A (zh) |
NZ (1) | NZ517202A (zh) |
PT (1) | PT1212422E (zh) |
WO (1) | WO2001014424A2 (zh) |
ZA (1) | ZA200201190B (zh) |
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CN102766210A (zh) * | 1999-08-24 | 2012-11-07 | 梅达里克斯公司 | 人ctla-4抗体及其应用 |
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